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Journal articles on the topic 'Aortic valve regurgitation'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Spina, Roberto, Chris Anthony, David WM Muller, and David Roy. "Transcatheter Aortic Valve Replacement for Native Aortic Valve Regurgitation." Interventional Cardiology Review 10, no. 1 (2015): 49. http://dx.doi.org/10.15420/icr.2015.10.1.49.

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Transcatheter aortic valve replacement with either the balloon-expandable Edwards SAPIEN XT valve, or the self-expandable CoreValve prosthesis has become the established therapeutic modality for severe aortic valve stenosis in patients who are not deemed suitable for surgical intervention due to excessively high operative risk. Native aortic valve regurgitation, defined as primary aortic incompetence not associated with aortic stenosis or failed valve replacement, on the other hand, is still considered a relative contraindication for transcatheter aortic valve therapies, because of the absence of annular or leaflet calcification required for secure anchoring of the transcatheter heart valve. In addition, severe aortic regurgitation often coexists with aortic root or ascending aorta dilatation, the treatment of which mandates operative intervention. For these reasons, transcatheter aortic valve replacement has been only sporadically used to treat pure aortic incompetence, typically on a compassionate basis and in surgically inoperable patients. More recently, however, transcatheter aortic valve replacement for native aortic valve regurgitation has been trialled with newer-generation heart valves, with encouraging results, and new ancillary devices have emerged that are designed to stabilize the annulus–root complex. In this paper we review the clinical context, technical characteristics and outcomes associated with transcatheter treatment of native aortic valve regurgitation.

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2

Liu, Lingchao, Tianbo Li, Bo Xu, Chencheng Liu, Fuqin Tang, Yingbin Xiao, and Yong Wang. "Mid-term follow-up of aortic valve replacement for bicuspid aortic valve." Cardiology in the Young 31, no. 8 (March 1, 2021): 1290–96. http://dx.doi.org/10.1017/s1047951121000160.

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AbstractObjective:The purpose of this study was to evaluate the mid-term outcome of aortic valve replacement for bicuspid aortic valve and tricuspid aortic valve and the related risk factors.Methods:From January 2014 to June 2019, 177 tricuspid aortic valve patients and 101 bicuspid aortic valve patients who underwent aortic valve replacement in our hospital were collected. 1:1 propensity score matching analysis was used to control the bias in patient selection. The perioperative and follow-up data between the two groups were compared. Independent risk factors which were associated with the continued dilatation of the ascending aorta were identified by univariate or multivariate logistic regression analysis.Results:After the matching procedure, 160 patients were included in the analysis (80 in each group). Baseline characteristics, intraoperative, and perioperative outcomes were similar between the two groups (all p > 0.05). Moreover, 67 patients in the tricuspid aortic valve group and 70 in the bicuspid aortic valve group completed the follow-up. The ascending aorta change, annual change rate, and the proportion of continuous dilation of ascending aorta in bicuspid aortic valve group were significantly higher than those in the tricuspid aortic valve group (p < 0.05). Multivariate logistic regression analysis showed that type 1 in bicuspid aortic valve (OR 5.173; 95% CI 1.772, 15.101; p = 0.003), aortic regurgitation (OR 3.673; 95% CI 1.133, 11.908; p = 0.030), and aortic valve stenosis with regurgitation (OR 6.489; 95% CI 1.726, 24.404; p = 0.006) were independent risk factors for the continued dilatation of the ascending aorta in all AV patients. Furthermore, the multivariate logistic regression analysis showed that type 1 in bicuspid aortic valve (OR 5.157; 95% CI 1.053, 25.272; p = 0.043), age ≥ 40 years (OR 6.956; 95% CI 1.228, 39.410; p = 0.028), and aortic regurgitation (OR 4.322; 95% CI 1.174, 15.911; p = 0.028) were independent risk factors for the continued dilatation of the ascending aorta in bicuspid aortic valve patients.Conclusion:Compared with tricuspid aortic valve patients, the ascending aorta of bicuspid aortic valve patients is more likely to continue to enlarge after aortic valve replacement. Type 1 in bicuspid aortic valve, age ≥ 40 years, and aortic regurgitation were the independent risk factors.

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3

Borer, Jeffrey S. "Aortic Valve Surgery for Aortic Regurgitation." Journal of the American College of Cardiology 68, no. 20 (November 2016): 2154–56. http://dx.doi.org/10.1016/j.jacc.2016.09.003.

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4

Evangelista, Arturo, Pastora Gallego, Francisco Calvo-Iglesias, Javier Bermejo, Juan Robledo-Carmona, Violeta Sánchez, Daniel Saura, et al. "Anatomical and clinical predictors of valve dysfunction and aortic dilation in bicuspid aortic valve disease." Heart 104, no. 7 (September 1, 2017): 566–73. http://dx.doi.org/10.1136/heartjnl-2017-311560.

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ObjectiveBicuspid aortic valve (BAV) is associated with early valvular dysfunction and proximal aorta dilation with high heterogeneity. This study aimed to assess the determinants of these complications.MethodsEight hundred and fifty-two consecutive adults diagnosed of BAV referred from cardiac outpatient clinics to eight echocardiographic laboratories of tertiary hospitals were prospectively recruited. Exclusion criteria were aortic coarctation, other congenital disorders or intervention. BAV morphotype, significant valve dysfunction and aorta dilation (≥2 Z-score) at sinuses and ascending aorta were established.ResultsThree BAV morphotypes were identified: right–left coronary cusp fusion (RL) in 72.9%, right–non-coronary (RN) in 24.1% and left–non-coronary (LN) in 3.0%. BAV without raphe was observed in 18.3%. Multivariate analysis showed aortic regurgitation (23%) to be related to male sex (OR: 2.80, p<0.0001) and valve prolapse (OR: 5.16, p<0.0001), and aortic stenosis (22%) to BAV-RN (OR: 2.09, p<0.001), the presence of raphe (OR: 2.75, p<0.001), age (OR: 1.03; p<0.001), dyslipidaemia (OR: 1.77, p<0.01) and smoking (OR: 1.63, p<0.05). Ascending aorta was dilated in 76% without differences among morphotypes and associated with significant valvular dysfunction. By contrast, aortic root was dilated in 34% and related to male sex and aortic regurgitation but was less frequent in aortic stenosis and BAV-RN.ConclusionsNormofunctional valves are more prevalent in BAV without raphe. Aortic stenosis is more frequent in BAV-RN and associated with some cardiovascular risk factors, whereas aortic regurgitation (AR) is associated with male sex and sigmoid prolapse. Although ascending aorta is the most commonly dilated segment, aortic root dilation is present in one-third of patients and associated with AR. Remarkably, BAV-RL increases the risk for dilation of the proximal aorta, whereas BAV-RN spares this area.

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5

Hertault, Adrien, Rachel E. Clough, Thomas Modine, Jean-Luc Auffray, Mohamad Koussa, and Stéphan Haulon. "Transcatheter Aortic Valve Implantation as a Bailout Procedure for Acute Aortic Valve Regurgitation During Endovascular Arch Repair." Journal of Endovascular Therapy 24, no. 5 (July 10, 2017): 656–60. http://dx.doi.org/10.1177/1526602817719880.

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Purpose: To report emergent transcatheter aortic valve implantation (TAVI) to treat acute severe aortic regurgitation caused by valve cusp dysfunction following proximal migration of an endograft implanted in the ascending aorta during endovascular arch repair. Case Report: A 65-year-old man had been previously treated with thoracic and fenestrated endografts in a 2-stage procedure for a chronic type B dissection. At 2-year follow-up, aneurysmal evolution of the distal arch led to development of a proximal type Ia endoleak. The patient was deemed unfit for open repair because of severe nonrevascularizable coronary artery disease. A custom-made endograft was designed consisting of a double inner branch arch endograft with a proximal component to reline the ascending aorta to avoid iatrogenic type A dissection. The first component was successfully deployed. However, this device migrated toward the aortic valve when the delivery system of the branch device was advanced through the aortic valve. Aortography and transesophageal echography showed acute aortic regurgitation due to obstruction of the left coronary valve cusp. An emergency bailout TAVI procedure was performed to successfully treat the aortic regurgitation. Conclusion: TAVI can be used as a bailout procedure for acute aortic valve dysfunction during endovascular arch or ascending aorta repair.

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6

ALJADAYEL, Hadi Abo, and Hussein ALKANJ. "Effect of Aortic Valve Replacement, for Aortic Stenosis, on Concomitant Mitral Valve Regurgitation." Turkiye Klinikleri Cardiovascular Sciences 27, no. 1 (2015): 22–27. http://dx.doi.org/10.5336/cardiosci.2014-42157.

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7

Friess, Jan Oliver, Thomas Bruelisauer, Samuel Hurni, Miralem Pasic, Gabor Erdoes, and Balthasar Eberle. "Resolution of severe secondary mitral valve regurgitation following aortic valve replacement in infective endocarditis." SAGE Open Medical Case Reports 9 (January 2021): 2050313X2110343. http://dx.doi.org/10.1177/2050313x211034377.

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We present the case of a patient with infective endocarditis anesthetized for replacement of severely regurgitant aortic valve. Intraoperative transesophageal echocardiography revealed a new diagnosis of severe secondary mitral regurgitation. After aortic valve replacement and tricuspid valve repair, severe mitral regurgitation resolved rapidly without any intervention. In multivalvular disease, instant spontaneous resolution of secondary mitral regurgitation is possible after surgical correction of an aortic regurgitation causing left ventricular volume overload.

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8

Hirofuji, Aina, Hirotsugu Kanda, Yuya Kitani, and Hiroyuki Kamiya. "Awake Surgical Mitral Valve Repair after Transcatheter Aortic Valve Replacement." Thoracic and Cardiovascular Surgeon Reports 10, no. 01 (January 2021): e15-e17. http://dx.doi.org/10.1055/s-0040-1718774.

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AbstractTranscatheter aortic valve replacement has become a popular choice for cases with severe aortic stenosis. However, when severe mitral regurgitation is comorbid in high-risk patients with severe aortic stenosis, therapeutic options must be weighed for each case. Here we present a very frail 88-year-old patient with severe aortic stenosis and severe mitral valve regurgitation who underwent a successful awake minimally invasive mitral valve repair after transcatheter aortic valve replacement.

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9

Jiang, Jubo, Xianbao Liu, Yuxin He, Qiyuan Xu, Qifeng Zhu, Sanjay Jaiswal, Lihan Wang, et al. "Transcatheter Aortic Valve Replacement for Pure Native Aortic Valve Regurgitation: A Systematic Review." Cardiology 141, no. 3 (2018): 132–40. http://dx.doi.org/10.1159/000491919.

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Background: Transcatheter aortic valve replacement (TAVR) is a recent and an effective treatment option for high- or extreme-surgical-risk patients with symptomatic severe aortic stenosis. However, pure severe native aortic valve regurgitation (NAVR) without aortic stenosis remains a contraindication to TAVR. The aim of our systemic review analysis was to evaluate TAVR in patients with pure NAVR. Methods: We searched the published articles in the PubMed and Web of Science databases (2002–2017) using the Boolean operators for studies of NAVR patients undergoing TAVR. Reference lists of all returned articles were searched recursively for other relevant citations. Pooled estimates were calculated using a random-effects meta-analysis. Results: Finally, a total of 10 studies were included in this analysis. The CoreValve was more frequently used with a lower rate of device success and a higher rate of residual aortic regurgitation. The new-generation transcatheter heart valves (THVs) performed a significantly higher rate with less residual aortic regurgitation and a success rate close to 100%. The 30-day all-cause mortality rates ranged from 0 to 30% with an estimate summary rate of 9% (95% CI: 5–15%; I2 = 33%). Cerebrovascular events, major or life-threatening bleeding, major vascular complications, acute kidney disease, and new permanent pacemaker implantation occurred similarly in both the new- and old-generation THV devices. Conclusions: Aortic regurgitation remains a challenging pathology for TAVR. TAVR is a feasible and reasonable option for carefully selected patients with pure aortic regurgitation.

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Chaudhury, Arnab. "An Unusual Complication of Infective Endocarditis Involving Bicuspid Aortic Valve." International Journal of Clinical Case Reports and Reviews 6, no. 3 (January 20, 2021): 01–04. http://dx.doi.org/10.31579/2690-4861/100.

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Bicuspid aortic valve is commonly associated with infective endocarditis with serious peri annular complications. We report a case of 37-year-old male patient presented with infective endocarditis involving bicuspid aortic valve with leaflet perforation and severe aortic regurgitation. Mitral valve was involved secondary to aortic valve endocarditis as a kissing lesion with severe mitral regurgitation. Anterior mitral leaflet (AML) had aneurysmal dilatation with mobile vegetations inside it. In colour Doppler, AML aneurysm was looking like a fireball inside the left atrium. Patient was treated with antibiotics and referred to surgery for aortic and mitral valve replacement.

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Makani, JospinKarel Bassakouahou, MeoStéphane Ikama, LouisIgor Kafata Ondze, and GiseleSuzy Kimbally Kaky. "Aortic valve regurgitation and acromegaly." Nigerian Journal of Cardiology 16, no. 2 (2019): 111. http://dx.doi.org/10.4103/njc.njc_4_19.

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Bertelsen, Litten, Niels Vejlstrup, Laura Andreasen, Morten Salling Olesen, and Jesper Hastrup Svendsen. "Cardiac magnetic resonance systematically overestimates mitral regurgitations by the indirect method." Open Heart 7, no. 2 (July 2020): e001323. http://dx.doi.org/10.1136/openhrt-2020-001323.

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ObjectiveCardiac MRI is quickly emerging as the gold standard for assessment of mitral regurgitation, most commonly with the indirect method subtracting forward flow in aorta from volumetric segmentation of the left ventricle. We aimed to investigate how aortic flow measurements with increasing distance from the aortic valve affect calculated mitral regurgitations and whether measurements were influenced by breath-hold regimen.MethodsFree-breathing and breath-hold phase contrast flows were measured in aorta at valve level, sinotubular (ST) junction, mid-ascending aorta and in the pulmonary trunk. Flow measurements were pairwise compared, and subsequently, after exclusion of patients with visible mitral and tricuspid regurgitations for left-sided and right-sided comparisons, respectively, flow-measured stroke volumes were compared with ventricular volumetric segmentations.ResultsThirty-nine participants without arrhythmias or structural abnormalities of the large vessels were included. Stroke volumes measured with free-breathing and breath-hold flow decreased equally with increasing distance to the aortic valves (breath-hold flow: aortic valve 105.6±20.8 mL, ST junction 101.5±20.7 mL, mid-ascending aorta 98.1±21.5 mL). After exclusion of atrioventricular regurgitations, stroke volumes determined by volumetric measurements were higher compared with values determined by flow measurements, corresponding to ‘false’ atrioventricular regurgitations of 8.0%±5.8% with flow measured at valve level, 11.6%±5.2% at the ST junction and 15.3%±5.0% at the mid-ascending aorta.ConclusionsStroke volumes determined by flow decrease throughout the proximal aorta and are systematically lower than volumetrically measured stroke volumes. The indirect method systematically overestimates mitral regurgitations, especially with increasing distance from the aortic valves.

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13

Garner, Megan. "Quadricuspid aortic valve with severe aortic regurgitation." Turkish Journal of Thoracic and Cardiovascular Surgery 25, no. 1 (January 19, 2017): 156–58. http://dx.doi.org/10.5606/tgkdc.dergisi.2017.13920.

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14

Costopoulos, Charis, Toru Naganuma, Azeem Latib, and Antonio Colombo. "Aortic regurgitation after transcatheter aortic valve implantation." Expert Review of Cardiovascular Therapy 11, no. 9 (September 2013): 1089–92. http://dx.doi.org/10.1586/14779072.2013.824688.

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15

Kuroki, Hidehito, Kazunobu Hirooka, and Masahiro Ohnuki. "Pentacuspid aortic valve causing severe aortic regurgitation." Journal of Thoracic and Cardiovascular Surgery 143, no. 2 (February 2012): e11-e12. http://dx.doi.org/10.1016/j.jtcvs.2011.10.069.

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Werner, Nikos, and Jan-Malte Sinning. "Aortic Regurgitation After Transcatheter Aortic Valve Replacement." Circulation Journal 78, no. 4 (2014): 811–18. http://dx.doi.org/10.1253/circj.cj-14-0113.

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17

Touma, Rabih, Preeti Ramappa, Neelima Katukuri, and Alexandros Briasoulis. "Severe aortic regurgitation of quadricuspid aortic valve." Acta Cardiologica 72, no. 1 (January 2, 2017): 83–84. http://dx.doi.org/10.1080/00015385.2017.1281547.

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18

Wang, Shengxun, Xu Meng, Haibo Zhang, Jiangang Wang, and Jie Han. "Pentacuspid Aortic Valve With Severe Aortic Regurgitation." Annals of Thoracic Surgery 89, no. 6 (June 2010): 2034–36. http://dx.doi.org/10.1016/j.athoracsur.2009.10.029.

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Izumoto, Hiroshi, Kohei Kawazoe, Kazuyuki Ishibashi, Hajime Kin, Tetsunori Kawase, Takayuki Nakajima, Satoshi Ohsawa, Kazuaki Ishihara, Yoshihiro Satoh, and Masataka Nasu. "Aortic valve repair in dominant aortic regurgitation." Japanese Journal of Thoracic and Cardiovascular Surgery 49, no. 6 (June 2001): 355–59. http://dx.doi.org/10.1007/bf02913149.

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20

Liu, Lulu, Sai Chen, Jun Shi, Chaoyi Qin, and Yingqiang Guo. "Transcatheter Aortic Valve Replacement in Aortic Regurgitation." Annals of Thoracic Surgery 110, no. 6 (December 2020): 1959–65. http://dx.doi.org/10.1016/j.athoracsur.2020.03.112.

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21

Woldow, Andrew B., R. Parameswaran, John Hartman, and Morris N. Kotler. "Aortic regurgitation due to aortic valve prolapse." American Journal of Cardiology 55, no. 11 (May 1985): 1435–37. http://dx.doi.org/10.1016/0002-9149(85)90525-9.

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22

Tatari, Hassan, Maziar Gholampour Dehaki, Gholamreza Omrani, Hafez Ghaheri, Alwaleed Al-Dairy, and Hojjat Mortezaeian. "Intraoperative diagnosis of a quadricuspid aortic valve." Asian Cardiovascular and Thoracic Annals 26, no. 9 (January 29, 2017): 704–6. http://dx.doi.org/10.1177/0218492317692467.

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Quadricuspid aortic valve is a rare anomaly, and most patients require surgery for aortic regurgitation in the 5th or 6th decades of life; only a few cases of aortic valve repair in childhood have been reported. A 3-year-old boy was scheduled for ventricular septal defect closure and aortic valve repair. Quadricuspid aortic valve was an incidental finding at operation; it was repaired by joining the left anterior and right anterior cusps. At the 9-month follow-up, the patient had no more than mild aortic regurgitation. We emphasize the importance of detecting this anomaly, especially in children with aortic valve regurgitation.

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Higa, Shotaro, Takaaki Nagano, Satoshi Yamashiro, and Masashi Iwabuchi. "Mitral valve perforation during transcatheter aortic valve replacement." Asian Cardiovascular and Thoracic Annals 28, no. 5 (June 2020): 276–78. http://dx.doi.org/10.1177/0218492320930842.

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An 86-year-old female with severe aortic valve stenosis underwent transcatheter aortic valve replacement. A balloon-expandable valve was used, guided by a double-stiff guidewire that successfully straightened the aorta. During valve placement, the balloon shifted. After placement of the prosthetic valve, intraoperative transesophageal echocardiography revealed severe mitral regurgitation from the anterior mitral leaflet. Open conversion was performed immediately. A 5-mm hole was identified in the anterior leaflet, and direct closure was chosen for mitral valve repair. While transcatheter aortic valve replacement has gained popularity for patients with severe aortic stenosis and high operative risk, reports of mitral valve perforation are rare.

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Mowafy, Hatem, Scott Lilly, David Orsinelli, Gregory Rushing, Juan Crestanello, and Konstantinos Boudoulas. "Aortic Dysfunction in Mitral Regurgitation Due to Floppy Mitral Valve/Mitral Valve Prolapse." AORTA 06, no. 03 (June 2018): 075–80. http://dx.doi.org/10.1055/s-0038-1669417.

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Background Floppy mitral valve/mitral valve prolapse (FMV/MVP), a heritable disorder of connective tissue, often leads to mitral regurgitation (MR) and is the most common cause for mitral valve surgery in developed countries. Connective tissue disorders may affect aortic function, and a stiff aorta may increase the severity of MR. Aortic function, however, has not been studied in FMV/MVP with MR. Methods A total of 17 patients (11 men, 6 women) with FMV/MVP and significant MR were compared with 20 controls matched for age and gender. Aortic diameters (AoD) were measured from left ventriculograms at 2 and 4 cm above the aortic valve. Aortic pressures were measured directly using fluid-filled catheters. Aortic distensibility was calculated using the formula: 2(systolic AoD—diastolic AoD)/(diastolic AoD x pulse pressure). Results Aortic distensibility was significantly lower in FMV/MVP compared with control at 2 cm above the aortic valve (1.00 ± 0.19 versus 3.78 ± 1.10 10−3 mm Hg−1, respectively; p = 0.027) and 4 cm above the aortic valve (0.89 ± 0.16 versus 3.22 ± 0.19 10−3 mm Hg−1, respectively; p = 0.007). FMV/MVP patients had greater left ventricular (LV) end-systolic (88 ± 72 mL versus 35 ± 15 mL, p = 0.002) and end-diastolic (165 ± 89 mL versus 100 ± 41 mL, p = 0.005) volumes, and lower LV ejection fraction, compared with control (50 ± 12% versus 57 ± 6%, p = 0.034). Conclusion Aortic distensibility is decreased (consistent with a stiff aorta) in patients with FMV/MVP and MR. A stiff aorta may increase the severity of MR. Thus, abnormal aortic function, which also deteriorates with age, may play an important role in the natural history of MR due to FMV/MVP.

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Balint, Brittany, Jan M. Federspiel, Tanja Schwab, Tristan Ehrlich, Frank Ramsthaler, and Hans-Joachim Schäfers. "Aortic Regurgitation Is Associated With Ascending Aortic Remodeling in the Nondilated Aorta." Arteriosclerosis, Thrombosis, and Vascular Biology 41, no. 3 (March 2021): 1179–90. http://dx.doi.org/10.1161/atvbaha.120.315739.

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Objective: The probability of aortic complications in patients with bicuspid aortic valve is higher in association with aortic regurgitation (AR) compared with aortic stenosis (AS) or normally functioning valves. The objective of this study was to determine whether this is related to the specific characteristics of aneurysmatic dilatation that includes AR or whether AR itself has a negative impact on the aortic wall, independent of aneurysmatic dilatation. Approach and Results: Nondilated aortic specimens were harvested intraoperatively from individuals with tricuspid aortic valves and either AS (n=10) or AR (n=16). For controls, nondilated aortas were harvested during autopsies from individuals with tricuspid aortic valves and no evidence of aortic valve disease (n=10). Histological and immunohistochemical analyses revealed that compared with control aortas, overall medial degeneration was more severe in AR-aortas ( P =0.005) but not AS-aortas ( P =0.23). This pathological remodeling included mucoid extracellular matrix accumulation ( P =0.005), elastin loss ( P =0.003), elastin fragmentation ( P =0.008), and decreased expression of fibrillin ( P =0.003) and collagen ( P =0.008). Furthermore, eNOS (endothelial nitric oxide synthase) expression was decreased in the intima ( P =0.0008) and in vasa vasorum ( P =0.004) of AR-aortas but not AS-aortas (all P >0.05). Likewise, subendothelial apoptosis was increased in AR-aortas ( P =0.03) but not AS-aortas ( P =0.50). Conclusions: AR has a negative effect on the nondilated ascending aortic wall. Accordingly, our results support the need for more detailed studies of the aortic wall in relation to aortic valve disease and may ultimately lead to more aggressive clinical monitoring and/or surgical criteria for patients with relevant AR. Graphic Abstract: A graphic abstract is available for this article.

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Zeeshan, Ahmad, Mojun Zhu, and John Elefteriades. "Immediate Improvement in Severe Mitral Regurgitation After Aortic Valve Replacement for Severe Aortic Insufficiency." AORTA 04, no. 03 (June 2016): 91–94. http://dx.doi.org/10.12945/j.aorta.2016.15.035.

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AbstractA 57-year-old male with ascending aortic aneurysm, severe aortic regurgitation, and severe mitral regurgitation (MR) underwent ascending aortic replacement and aortic valve replacement. MR in this patient with normal mitral valve morphology was considered secondary to aortic valve incompetency. Consequently, a surgical approach to restore aortic valve function was adopted with successful MR resolution. This case report demonstrates the possibility of reversing early functional mitral regurgitation without surgically approaching the mitral valve.

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Bilbija, Ilija, Milos Matkovic, Marko Cubrilo, Nemanja Aleksic, Jelena Milin Lazovic, Jelena Cumic, Vladimir Tutus, Marko Jovanovic, and Svetozar Putnik. "The Prospects of Secondary Moderate Mitral Regurgitation after Aortic Valve Replacement —Meta-Analysis." International Journal of Environmental Research and Public Health 17, no. 19 (October 8, 2020): 7335. http://dx.doi.org/10.3390/ijerph17197335.

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Aortic valve replacement for aortic stenosis represents one of the most frequent surgical procedures on heart valves. These patients often have concomitant mitral regurgitation. To reveal whether the moderate mitral regurgitation will improve after aortic valve replacement alone, we performed a systematic review and meta-analysis. We identified 27 studies with 4452 patients that underwent aortic valve replacement for aortic stenosis and had co-existent mitral regurgitation. Primary end point was the impact of aortic valve replacement on the concomitant mitral regurgitation. Secondary end points were the analysis of the left ventricle reverse remodeling and long-term survival. Our results showed that there was significant improvement in mitral regurgitation postoperatively (RR, 1.65; 95% CI 1.36–2.00; p < 0.00001) with the average decrease of 0.46 (WMD; 95% CI 0.35–0.57; p < 0.00001). The effect is more pronounced in the elderly population. Perioperative mortality was higher (p < 0.0001) and long-term survival significantly worse (p < 0.00001) in patients that had moderate/severe mitral regurgitation preoperatively. We conclude that after aortic valve replacement alone there are fair chances but for only slight improvement in concomitant mitral regurgitation. The secondary moderate mitral regurgitation should be addressed at the time of aortic valve replacement. A more conservative approach should be followed for elderly and high-risk patients.

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Di Pino, Alfredo, Placido Gitto, Antonio Silvia, and Innocenzo Bianca. "Congenital quadricuspid aortic valve in children." Cardiology in the Young 18, no. 3 (June 2008): 324–27. http://dx.doi.org/10.1017/s1047951108002205.

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AbstractQuadricuspid aortic valves are rare congenital anomalies, usually diagnosed in adult patients affected by severe aortic regurgitation. We have now encountered three such valves in children undergoing transthoracic echocardiography. All children were asymptomatic. The first child possessed a valve with two larger leaflets, and smaller leaflets of equal size. In the second child, 3 leaflets were of equal size, with 1 small accessory leaflet. The third child had a valve with four leaflets of approximately equal size. In one child, the aortic valve was functioning normally, and came to attention because of mitral valvar prolapse causing mild regurgitation. In the remaining two children, central mild aortic regurgitation was detected using colour flow analysis, and associated dilation of the aortic root was revealed by measurements of the cross-sectional images.

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29

Russell, Richard O. "Timing of aortic valve replacement in chronic aortic valve regurgitation." Journal of the American College of Cardiology 11, no. 5 (May 1988): 930–31. http://dx.doi.org/10.1016/s0735-1097(98)90047-x.

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30

Dhillon, P. S., N. Kakouros, and S. J. D. Brecker. "Transcatheter aortic valve replacement for symptomatic severe aortic valve regurgitation." Heart 96, no. 10 (May 1, 2010): 810. http://dx.doi.org/10.1136/hrt.2009.190421.

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31

Yoon, Sung-Han, Tobias Schmidt, Sabine Bleiziffer, Niklas Schofer, Claudia Fiorina, Antonio J. Munoz-Garcia, Ermela Yzeiraj, et al. "Transcatheter Aortic Valve Replacement in Pure Native Aortic Valve Regurgitation." Journal of the American College of Cardiology 70, no. 22 (December 2017): 2752–63. http://dx.doi.org/10.1016/j.jacc.2017.10.006.

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Kaneko, Hidehiro, Frank Hoelschermann, Grit Tambor, Michael Neuss, and Christian Butter. "Rescue Valve-in-Valve Transcatheter Aortic Valve Replacement for Pure Aortic Regurgitation." JACC: Cardiovascular Interventions 10, no. 3 (February 2017): e23-e24. http://dx.doi.org/10.1016/j.jcin.2016.11.031.

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Auriemma, Renata S., Rosario Pivonello, Ylenia Perone, Ludovica F. S. Grasso, Lucia Ferreri, Chiara Simeoli, Davide Iacuaniello, Maurizio Gasperi, and Annamaria Colao. "Safety of long-term treatment with cabergoline on cardiac valve disease in patients with prolactinomas." European Journal of Endocrinology 169, no. 3 (September 2013): 359–66. http://dx.doi.org/10.1530/eje-13-0231.

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ObjectiveCabergoline (CAB) has been found to be associated with increased risk of cardiac valve regurgitation in Parkinson's disease, whereas several retrospective analyses failed to detect a similar relation in hyperprolactinemic patients. The current study aimed at investigating cardiac valve disease before and after 24 and 60 months of continuous treatment with CAB only in patients with hyperprolactinemia.Subjects and methodsForty patients (11 men and 29 women, aged 38.7±12.5 years) newly diagnosed with hyperprolactinemia entered the study. Cumulative CAB dose ranged from 12 to 588 mg (median 48 mg) at 24 months and 48–1260 mg (median 149 mg) at 60 months. All patients underwent a complete trans-thoracic echocardiographic examination. Valve regurgitation was assessed according to the American Society of Echocardiography.ResultsAt baseline, the prevalence of trace mitral, aortic, pulmonic, and tricuspid regurgitations was 20, 2.5, 10, and 40% respectively, with no patient showing clinically relevant valvulopathy. After 24 months, no change in the prevalence of trace mitral (P=0.78) and pulmonic (P=0.89) regurgitations and of mild aortic (P=0.89) and tricuspid (P=0.89) regurgitations was found when compared with baseline. After 60 months, the prevalence of trace tricuspid regurgitation was only slightly increased when compared with that after 24 months (37.5%; P=0.82), but none of the patients developed significant valvulopathy. No correlation was found between cumulative dose and prevalence or grade of valve regurgitation at both evaluations. Prolactin levels normalized in all patients but one.ConclusionCAB does not increase the risk of significant cardiac valve regurgitation in prolactinomas after the first 5 years of treatment.

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Lee, James C., Kelley R. Branch, Christian Hamilton-Craig, and Eric V. Krieger. "Evaluation of aortic regurgitation with cardiac magnetic resonance imaging: a systematic review." Heart 104, no. 2 (August 19, 2017): 103–10. http://dx.doi.org/10.1136/heartjnl-2016-310819.

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This review summaries the utility, application and data supporting use of cardiac magnetic resonance imaging (CMR) to evaluate and quantitate aortic regurgitation. We systematically searched Medline and PubMed for original research articles published since 2000 that provided data on the quantitation of aortic regurgitation by CMR and identified 11 articles for review. Direct aortic measurements using phase contrast allow quantitation of volumetric flow across the aortic valve and are highly reproducible and accurate compared with echocardiography. However, this technique requires diligence in prescribing the correct imaging planes in the aorta. Volumetric analytic techniques using differences in ventricular volumes are also highly accurate but less than phase contrast techniques and only accurate when concomitant valvular disease is absent. Comparison of both aortic and ventricular data for internal data verification ensures fidelity of aortic regurgitant data. CMR data can be applied to many types of aortic valve regurgitation including combined aortic stenosis with regurgitation, congenital valve diseases and post-transcatheter valve placement. CMR also predicts those patients who progress to surgery with high overall sensitivity and specificity. Future studies of CMR in patients with aortic regurgitation to quantify the incremental benefit over echocardiography as well as prediction of cardiovascular events are warranted.

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Aydin, Unal, Mehmet Gul, Serkan Aslan, Emre Akkaya, and Aydin Yildirim. "Concomitant Transapical Transcatheter Valve Implantations: Edwards Sapien Valve for Severe Mitral Regurgitation in a Patient with Failing Mitral Bioprostheses and JenaValve for the Treatment of Pure Aortic Regurgitation." Heart Surgery Forum 18, no. 2 (April 28, 2015): 053. http://dx.doi.org/10.1532/hsf.1238.

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Transcatheter valve implantation is a novel interventional technique, which was developed as an alternative therapy for surgical aortic valve replacement in inoperable patients with severe aortic stenosis. Despite limited experience in using transcatheter valve implantation for mitral and aortic regurgitation, transapical transcatheter aortic valve implantation and valve-in-valve implantation for degenerated mitral valve bioprosthesis can be performed in high-risk patients who are not candidates for conventional replacement surgery. In this case, we present the simultaneous transcatheter valve implantation via transapical approach for both degenerated bioprosthetic mitral valve with severe regurgitation and pure severe aortic regurgitation.

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BUGAN, BARIS. "Paravalvular aortic regurgitation after transcatheter aortic valve replacement." Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology 42, no. 1 (2014): 83–93. http://dx.doi.org/10.5543/tkda.2014.93636.

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TABAYASHI, KOICHI, MITUAKI SADAHIRO, GENYA YAGINUMA, YASUHIRO ITO, MASATO ENDO, KOJI AKIMOTO, YASUYUKI SUZUKI, and HITOSHI MOHRI. "Aortic regurgitation: Ventricular response after aortic valve replacement." Tohoku Journal of Experimental Medicine 160, no. 2 (1990): 109–15. http://dx.doi.org/10.1620/tjem.160.109.

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Yang, Li-Tan, Patricia A. Pellikka, Maurice Enriquez-Sarano, and Hector I. Michelena. "PROGRESSION OF AORTIC REGURGITATION IN BICUSPID AORTIC VALVE." Journal of the American College of Cardiology 75, no. 11 (March 2020): 2131. http://dx.doi.org/10.1016/s0735-1097(20)32758-3.

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Bakirci, Eftal Murat, Sakir Arslan, Husnu Degirmenci, and Serdar Sevimli. "A quadricuspid aortic valve causing moderate aortic regurgitation." Cardiology Journal 19, no. 6 (December 6, 2012): 632–34. http://dx.doi.org/10.5603/cj.2012.0116.

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MATSUMOTO, MASAHIKO, SHIGEHIKO MIKI, KENJI KUSUHARA, YUICHI UEDA, YUTAKA OHKITA, TAKAFUMI TAHATA, and MASASHI KOMEDA. "Quadricuspid aortic valve associated with severe aortic regurgitation." Japanese Circulation Journal 49, no. 2 (1985): 190–91. http://dx.doi.org/10.1253/jcj.49.190.

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Ducrocq, Gregory, Dominique Himbert, Ulrik Hvass, and Alec Vahanian. "Compassionate aortic valve implantation for severe aortic regurgitation." Journal of Thoracic and Cardiovascular Surgery 140, no. 4 (October 2010): 930–32. http://dx.doi.org/10.1016/j.jtcvs.2010.02.003.

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Dean, Larry S., Jerry W. Chandler, Carlos B. Saenz, William A. Baxley, and Thomas M. Bulle. "Severe aortic regurgitation complicating percutaneous aortic valve valvuloplasty." Catheterization and Cardiovascular Diagnosis 16, no. 2 (February 1989): 130–32. http://dx.doi.org/10.1002/ccd.1810160213.

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Aoyagi, S., T. Kawara, H. Yasunaga, K. Kosuga, and K. Oishi. "Congenital Quadricuspid Aortic Valve associated with Aortic Regurgitation." Thoracic and Cardiovascular Surgeon 40, no. 04 (August 1992): 225–26. http://dx.doi.org/10.1055/s-2007-1020156.

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Karavelioğlu, Yusuf, İsmail Ekinözü, Mücahit Yetim, and Macit Kalçık. "A Quadricuspid Aortic Valve with Mild Aortic Regurgitation." Kosuyolu Heart Journal 22, no. 2 (August 1, 2019): 134–40. http://dx.doi.org/10.5578/khj.68258.

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Wendt, Daniel, Philipp Kahlert, Susanne Pasa, Karim El-Chilali, Fadi Al-Rashid, Konstantinos Tsagakis, Daniel Sebastian Dohle, Raimund Erbel, Heinz Jakob, and Matthias Thielmann. "Transapical Transcatheter Aortic Valve for Severe Aortic Regurgitation." JACC: Cardiovascular Interventions 7, no. 10 (October 2014): 1159–67. http://dx.doi.org/10.1016/j.jcin.2014.04.016.

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Yang, Li-Tan, Patricia A. Pellikka, Maurice Enriquez-Sarano, Joseph F. Maalouf, Christopher G. Scott, and Hector I. Michelena. "Stage B Aortic Regurgitation in Bicuspid Aortic Valve." JACC: Cardiovascular Imaging 13, no. 6 (June 2020): 1442–45. http://dx.doi.org/10.1016/j.jcmg.2020.01.012.

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Kaplan, James, Andrew Farb, Nathan H. Carliner, and Renu Virmani. "Large aortic valve fenestrations producing chronic aortic regurgitation." American Heart Journal 122, no. 5 (November 1991): 1475–77. http://dx.doi.org/10.1016/0002-8703(91)90597-b.

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Kin, Hajime, Kenji Minatoya, Masayuki Mukaida, and Hitoshi Okabayashi. "Successful valve repair in traumatic aortic valve regurgitation." Interactive CardioVascular and Thoracic Surgery 12, no. 5 (May 2011): 869–71. http://dx.doi.org/10.1510/icvts.2010.262097.

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Isbır, Selım C., and Yasar Bırkan. "Transcatheter Aortic Valve Implantation and Atrioventrıcular Valve Regurgitation." Annals of Thoracic Surgery 96, no. 4 (October 2013): 1531. http://dx.doi.org/10.1016/j.athoracsur.2013.04.081.

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Tuzcu, E. Murat, Samir R. Kapadia, and Lars G. Svensson. "Valve Design and Paravalvular Aortic Regurgitation." Circulation 129, no. 13 (April 2014): 1378–80. http://dx.doi.org/10.1161/circulationaha.114.008748.

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