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Journal articles on the topic 'Aortic valve stenosis (AVS)'

Author: Grafiati

Published: 9 November 2024

Last updated: 31 July 2025

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1

Frank, Rolf Dario, Regina Lanzmich, Philipp K. Haager, and Ulrich Budde. "Severe Aortic Valve Stenosis." Clinical and Applied Thrombosis/Hemostasis 23, no. 3 (2016): 229–34. http://dx.doi.org/10.1177/1076029616660759.

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Aortic valve stenosis (AVS) is the most common valve disease in adults. Severe forms are associated with acquired von Willebrand syndrome (aVWS) with loss of the largest von Willebrand factor (VWF) multimers. Diagnostic gold standard is the VWF multimer analysis. Valve replacement rapidly restores the VWF structure. Uncertainty exists if this effect is permanent and how functional VWF assays perform compared with multimer analysis. We studied 21 consecutive patients with severe AVS before and 6 to 18 months after valve surgery and compared them with 14 controls without valve disease referred f

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Rakhmanov, Yeltay, Paolo Enrico Maltese, Alessandra Zulian, et al. "Genetic testing for aortic valve stenosis." EuroBiotech Journal 2, s1 (2018): 61–63. http://dx.doi.org/10.2478/ebtj-2018-0040.

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Abstract Aortic valve stenosis (AVS) is a congenital aortic defect in which the aortic lumen narrows due to thickening or calcification of the aortic valve without obstructing left ventricular outflow. Depending on the site of obstruction, AVS is classified as valvular, sub-valvular or supra-valvular. The prevalence of AVS is about 3% and increases with age. One in eight persons over the age of 75 years has moderate or severe AVS. AVS has autosomal dominant inheritance. It can be associated with mutations in the following genes: NOTCH1, SMAD6, SMAD4, and ELN. This Utility Gene Test was develop

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3

Sossong, Verena, Thomas Helbing, Friedhelm Beyersdorf, et al. "Increased levels of circulating microparticles in patients with severe aortic valve stenosis." Thrombosis and Haemostasis 99, no. 04 (2008): 711–19. http://dx.doi.org/10.1160/th07-05-0334.

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SummaryThe mechanisms of the progression of aortic valve stenosis are unknown. The involvement of mononuclear cells and of chronic systemic inflammation has been suggested by analysis of pathological specimens. We hypothesize that shear stress caused by the constricted aortic orifice contributes to systemic proinflammation by activation of circulating blood cells and thereby generation of microparticles. Using flow cytometry we analyzed 22 patients with severe aortic valve stenosis (AVS) and 18 patient controls for the generation of circulating microparticles from platelet-(PMPs: CD31+/CD61+ o

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Oostveen, Reindert F., Yannick Kaiser, Erik S. G. Stroes, and Hein J. Verberne. "Molecular Imaging of Aortic Valve Stenosis with Positron Emission Tomography." Pharmaceuticals 15, no. 7 (2022): 812. http://dx.doi.org/10.3390/ph15070812.

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Aortic valve stenosis (AVS) is an increasingly prevalent disease in our aging population. Although multiple risk factors for AVS have been elucidated, medical therapies capable of slowing down disease progression remain unavailable. Molecular imaging technologies are opening up avenues for the non-invasive assessment of disease progression, allowing the assessment of (early) medical interventions. This review will focus on the role of positron emission tomography of the aortic valve with 18F-fluorodeoxyglucose and 18F-sodium fluoride but will also shed light on novel tracers which have potenti

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Perrucci, Gianluca L., Marco Zanobini, Paola Gripari, et al. "Pathophysiology of Aortic Stenosis and Mitral Regurgitation." Comprehensive Physiology 7, no. 3 (2017): 799–818. https://doi.org/10.1002/j.2040-4603.2017.tb00762.x.

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ABSTRACTThe global impact of the spectrum of valve diseases is a crucial, fast‐growing, and underrecognized health problem. The most prevalent valve diseases, requiring surgical intervention, are represented by calcific and degenerative processes occurring in heart valves, in particular, aortic and mitral valve. Due to the increasing elderly population, these pathologies will gain weight in the global health burden. The two most common valve diseases are aortic valve stenosis (AVS) and mitral valve regurgitation (MR). AVS is the most commonly encountered valve disease nowadays and affects almo

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Schnitzler, Johan G., Lubna Ali, Anouk G. Groenen, Yannick Kaiser, and Jeffrey Kroon. "Lipoprotein(a) as Orchestrator of Calcific Aortic Valve Stenosis." Biomolecules 9, no. 12 (2019): 760. http://dx.doi.org/10.3390/biom9120760.

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Aortic valve stenosis (AVS) is the most prevalent valvular heart disease in the Western World with exponentially increased incidence with age. If left untreated, the yearly mortality rates increase up to 25%. Currently, no effective pharmacological interventions have been established to treat or prevent AVS. The only treatment modality so far is surgical or transcatheter aortic valve replacement (AVR). Lipoprotein(a) [Lp(a)] has been implicated as a pivotal player in the pathophysiology of calcification of the valves. Patients with elevated levels of Lp(a) have a higher risk of hospitalization

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Bardelli, Moreno, Monica Cavressi, Giulia Furlanis, et al. "Relationship between aortic valve stenosis and the hemodynamic pattern in the renal circulation, and restoration of the flow wave profile after correction of the valvular defect." Journal of International Medical Research 48, no. 9 (2020): 030006052095690. http://dx.doi.org/10.1177/0300060520956907.

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Objective The index of maximal systolic acceleration ([AImax]: maximal systolic acceleration of the Doppler waveform divided by peak systolic velocity) shows diagnostic accuracy in screening of renal artery stenosis. This study aimed to determine whether an upstream factor of resistance, such as aortic valve stenosis (AVS), can affect Doppler parameters detected in the peripheral arteries. Methods In this prospective study, we measured the AImax in non-stenotic renal interlobar arteries of 62 patients with AVS. Patients were divided into three groups on the basis of severity of valvulopathy as

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Artiach, Gonzalo, Miguel Carracedo, Till Seime, et al. "Proteoglycan 4 is Increased in Human Calcified Aortic Valves and Enhances Valvular Interstitial Cell Calcification." Cells 9, no. 3 (2020): 684. http://dx.doi.org/10.3390/cells9030684.

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Aortic valve stenosis (AVS), a consequence of increased fibrosis and calcification of the aortic valve leaflets, causes progressive narrowing of the aortic valve. Proteoglycans, structural components of the aortic valve, accumulate in regions with fibrosis and moderate calcification. Particularly, proteoglycan 4 (PRG4) has been identified in fibrotic parts of aortic valves. However, the role of PRG4 in the context of AVS and aortic valve calcification has not yet been determined. Here, transcriptomics, histology, and immunohistochemistry were performed in human aortic valves from patients unde

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Ferrari, V., C. Mazzanti, and L. De Biase. "RELATION BETWEEN CALCIUM METABOLISM AND DEVELOPMENT OF AORTIC VALVE STENOSIS." European Heart Journal Supplements 26, Supplement_2 (2024): ii209. http://dx.doi.org/10.1093/eurheartjsupp/suae036.501.

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Abstract The role of calcium metabolism in the development of degenerative Aortic Valve Stenosis (AVS) is not completely understood. Valvular cell modifications and passive calcification can be both involved in the diseases. Vitamin D (Vit D) and Parathyroid Hormone (PTH) are important factor in calcium regulation and data on their modification in AVS are scanty. Their potential role in AVS prevention is not yet identified. Osteocalcin can be considered a marker of calcification and its potential usefulness in identification of patient at risk for AVS was not studied. In order to correlate cal

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Krzesińska, Aleksandra, Maria Nowak, Agnieszka Mickiewicz, et al. "Lipoprotein(a) As a Potential Predictive Factor for Earlier Aortic Valve Replacement in Patients with Bicuspid Aortic Valve." Biomedicines 11, no. 7 (2023): 1823. http://dx.doi.org/10.3390/biomedicines11071823.

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Bicuspid aortic valve (BAV) affects 0.5–2% of the general population and constitutes the major cause of severe aortic valve stenosis (AVS) in individuals ≤70 years. The aim of the present study was to evaluate the parameters that may provide information about the risk of AVS developing in BAV patients, with particular emphasis on lipoprotein(a) (Lp(a)), which is a well-recognized risk factor for stenosis in the general population. We also analyzed the impact of autotaxin (ATX) and interleukin-6 (IL-6) as parameters potentially related to the pathomechanism of Lp(a) action. We found that high L

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Torres-Arellano, José M., Juan C. Echeverría, Nydia Ávila-Vanzzini, et al. "Cardiac Autonomic Response to Active Standing in Calcific Aortic Valve Stenosis." Journal of Clinical Medicine 10, no. 9 (2021): 2004. http://dx.doi.org/10.3390/jcm10092004.

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Aortic stenosis is a progressive heart valve disorder characterized by calcification of the leaflets. Heart rate variability (HRV) analysis has been proposed for assessing the heart response to autonomic activity, which is documented to be altered in different cardiac diseases. The objective of the study was to evaluate changes of HRV in patients with aortic stenosis by an active standing challenge. Twenty-two volunteers without alterations in the aortic valve (NAV) and twenty-five patients diagnosed with moderate and severe calcific aortic valve stenosis (AVS) participated in this cross-secti

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Perpétuo, Luís, António S. Barros, Jéssica Dalsuco, et al. "Coronary Artery Disease and Aortic Valve Stenosis: A Urine Proteomics Study." International Journal of Molecular Sciences 23, no. 21 (2022): 13579. http://dx.doi.org/10.3390/ijms232113579.

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Coronary artery disease (CAD) and the frequently coexisting aortic valve stenosis (AVS) are heart diseases accounting for most cardiac surgeries. These share many risk factors, such as age, diabetes, hypertension, or obesity, and similar pathogenesis, including endothelial disruption, lipid and immune cell infiltration, inflammation, fibrosis, and calcification. Unsuspected CAD and AVS are sometimes detected opportunistically through echocardiography, coronary angiography, and magnetic resonance. Routine biomarkers for early detection of either of these atherosclerotic-rooted conditions would

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Echeverría, Juan C., Nydia Ávila-Vanzzini, Rashidi Springall, et al. "Inflammation and Reduced Parasympathetic Cardiac Modulation in Aortic-Valve Sclerosis." Applied Sciences 9, no. 19 (2019): 4020. http://dx.doi.org/10.3390/app9194020.

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Aortic-valve sclerosis increases cardiovascular mortality risk and precedes aortic-valve stenosis, but its mechanisms are not well understood. The purpose of this study was to compare the cardiac autonomic modulation and inflammation markers between subjects with aortic-valve normal leaflets and subjects with aortic-valve sclerosis. According to 2-D transthoracic echocardiograms, 61 middle-aged volunteers without chronic or acute illnesses were classified in two groups: with no aortic-valve sclerosis (NAVS, N = 16) and with aortic-valve sclerosis (AVS, N = 45). An electrocardiogram at the supi

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Manchester, Emily L., Selene Pirola, Mohammad Yousuf Salmasi, Declan P. O’Regan, Thanos Athanasiou, and Xiao Yun Xu. "Analysis of Turbulence Effects in a Patient-Specific Aorta with Aortic Valve Stenosis." Cardiovascular Engineering and Technology 12, no. 4 (2021): 438–53. http://dx.doi.org/10.1007/s13239-021-00536-9.

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Abstract Blood flow in the aorta is often assumed laminar, however aortic valve pathologies may induce transition to turbulence and our understanding of turbulence effects is incomplete. The aim of the study was to provide a detailed analysis of turbulence effects in aortic valve stenosis (AVS). Methods Large-eddy simulation (LES) of flow through a patient-specific aorta with AVS was conducted. Magnetic resonance imaging (MRI) was performed and used for geometric reconstruction and patient-specific boundary conditions. Computed velocity field was compared with 4D flow MRI to check qualitative

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Matilla, Lara, Eva Jover, Mattie Garaikoetxea, et al. "Sex-Related Signaling of Aldosterone/Mineralocorticoid Receptor Pathway in Calcific Aortic Stenosis." Hypertension 79, no. 8 (2022): 1724–37. http://dx.doi.org/10.1161/hypertensionaha.122.19526.

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Background: There are sex differences in the pathophysiology of aortic valve (AV) calcification in patients with aortic stenosis, although the molecular and cellular mechanisms have not been elucidated. Aldosterone (Aldo) promotes proteoglycan synthesis in valve interstitial cells (VICs) from mitral valves via the mineralocorticoid receptor (MR). We investigated the influence of sex in the role of Aldo/MR pathway in AV alterations in patients with aortic stenosis. METHODS AND RESULTS: MR was expressed by primary aortic VICs and in AVs from patients with aortic stenosis. MR expression positivel

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Gebhard, C., F. Maafi, B. Stähli, et al. "Beneficial Effects of High-Density Lipoproteins on Acquired von Willebrand Syndrome in Aortic Valve Stenosis." Thrombosis and Haemostasis 118, no. 02 (2018): 288–97. http://dx.doi.org/10.1160/th17-10-0729.

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Background Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-weight von Willebrand factor (vWF) multimers (HMWM), the latter being a consequence of increased shear stress and enhanced vWF-cleaving protease (ADAMTS-13) activity. Although antithrombotic actions of HDL have been described, its effects on ADAMTS-13 and vWF in AVS are unknown.

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Lassalle, Fanny, Mickael Rosa, Bart Staels, Eric Van Belle, Sophie Susen, and Annabelle Dupont. "Circulating Monocyte Subsets and Transcatheter Aortic Valve Replacement." International Journal of Molecular Sciences 23, no. 10 (2022): 5303. http://dx.doi.org/10.3390/ijms23105303.

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Transcatheter aortic valve replacement (TAVR), as an alternative to open heart surgery, has revolutionized the treatment of severe aortic valve stenosis (AVS), the most common valvular disorder in the elderly. AVS is now considered a form of atherosclerosis and, like the latter, partly of inflammatory origin. Patients with high-grade AVS have a highly disturbed blood flow associated with high levels of shear stress. The immediate reopening of the valve during TAVR leads to a sudden restoration of a normal blood flow hemodynamic. Despite its good prognosis for patients, TAVR remains associated

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Peeters, Frederique E. C. M., Bas L. J. H. Kietselaer, Judith Hilderink, et al. "Biological variation of cardiac markers in patients with aortic valve stenosis." Open Heart 6, no. 1 (2019): e001040. http://dx.doi.org/10.1136/openhrt-2019-001040.

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ObjectiveCardiac biomarkers hold promise for follow-up and management of aortic valve stenosis (AVS). When interpreting serial biomarker measurements of patients with AVS, it can be challenging to distinguish ‘real changes’ from ‘random fluctuation’. Hence, robust estimation of the biological variation of these biomarkers is essential. In the present study we assessed biological variation of B-type natriuretic peptide (BNP), N-terminus pro-brain natriuretic peptide (NT-proBNP), high-sensitivity troponin-T and high-sensitivity troponin-I (hs-TnT and hs-TnI), and ST2 in subjects with stable AVS.

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Le, Bao. "Comparative Analysis of TAVR and SAVR for Treatment of Aortic Valve Disease: Innovations and Implications." International Journal of Social Science and Economic Research 09, no. 12 (2024): 6290–301. https://doi.org/10.46609/ijsser.2024.v09i12.042.

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Aortic valve disease (AVD) encompasses significant pathologies such as aortic valve stenosis (AVS) and regurgitation, primarily affecting the elderly population. This review examines four prevalent treatments for AVD: Surgical Aortic Valve Replacement (SAVR), Transcatheter Aortic Valve Replacement (TAVR), Sutureless Aortic Valve Replacement (SuAVR), and Balloon Aortic Valvuloplasty (BAV). We explore the epidemiology, etiology, and global impact of AVD, highlighting the economic burden associated with untreated cases. A comparative analysis of SAVR and TAVR reveals differences in risk profiles,

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Nappi, Francesco, Camille Bourgois, Antonio Nenna, et al. "Study protocol for an internahaational prospective non-randomised trial evaluating the long-term outcomes of transcatheter aortic valve implantation versus surgical aortic valve replacement for aortic-valve stenosis in patients at risk to severe valve obstruction: the TAVISAR trial." BMJ Open 15, no. 5 (2025): e101417. https://doi.org/10.1136/bmjopen-2025-101417.

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BackgroundAortic valve stenosis (AVS) represents the most prevalent primary valvular lesion necessitating surgical intervention or transcatheter intervention in Europe and North America. Its prevalence is increasing at a rapid rate as a consequence of the ageing population. A variety of mechanical interventions are available to determine the management of AVS; however, there is currently a paucity of robust data with which to perform a comparative analysis of the efficacy of surgical aortic valve replacement (SAVR) and that of conventional stented xenograft bioprostheses (BP) or sutureless aor

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Vieceli Dalla Sega, Francesco, Francesca Fortini, Paolo Cimaglia, et al. "COX-2 Is Downregulated in Human Stenotic Aortic Valves and Its Inhibition Promotes Dystrophic Calcification." International Journal of Molecular Sciences 21, no. 23 (2020): 8917. http://dx.doi.org/10.3390/ijms21238917.

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Calcific aortic valve disease (CAVD) is the result of maladaptive fibrocalcific processes leading to a progressive thickening and stiffening of aortic valve (AV) leaflets. CAVD is the most common cause of aortic stenosis (AS). At present, there is no effective pharmacotherapy in reducing CAVD progression; when CAVD becomes symptomatic it can only be treated with valve replacement. Inflammation has a key role in AV pathological remodeling; hence, anti-inflammatory therapy has been proposed as a strategy to prevent CAVD. Cyclooxygenase 2 (COX-2) is a key mediator of the inflammation and it is th

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Irtyuga, O. B., E. V. Zhiduleva, E. E. Kazakova, and O. M. Moiseeva. "PATHOGENESIS OF AORTIC STENOSIS IN HYPERTENSIVE PATIENTS." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 19, no. 6 (2013): 495–501. http://dx.doi.org/10.18705/1607-419x-2013-19-6-495-501.

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Objective. To assess osteoprotegerin (OPG) and soluble ligand receptor activator of transcription factor kappa-B (RANKL) levels in patients with aortic stenosis and systemic hypertension.Design and methods. Sixty-one patients with aortic valve stenosis (AVS) [31 patients with bicuspid aortic valve (BAV) and 30 patients with tricuspid aortic valve (TAV)] were examined. Thirty-two patients without heart diseases formed the control group. Serum levels of C-reactive protein, ОPG, sRANKL and lipid profile were assessed in all patients.Results. Elevated blood pressure (BP) was found in 93 % patients

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Yalta, Kenan, Orkide Palabiyik, Muhammet Gurdogan, and Yekta Gurlertop. "Serum copeptin might improve risk stratification and management of aortic valve stenosis: a review of pathophysiological insights and practical implications." Therapeutic Advances in Cardiovascular Disease 13 (January 2019): 175394471982642. http://dx.doi.org/10.1177/1753944719826420.

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Over recent decades, the prevalence of aortic valve stenosis (AVS) has been constantly increasing possibly owing to the aging of general population. Severe AVS as determined by an aortic valve area (AVA) of <1 cm2 has been regarded as a serious clinical condition potentially associated with a variety of adverse outcomes, including sudden cardiac death (SCD). However, patients with severe AVS (in the absence of overt high-risk features) are usually evaluated and managed exclusively based on symptomatology or imperfect prognostic tools including exercise testing and biomarkers, with a potenti

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Artiach, Gonzalo, Miguel Carracedo, Oscar Plunde, et al. "Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis." Circulation 142, no. 8 (2020): 776–89. http://dx.doi.org/10.1161/circulationaha.119.041868.

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Background: Aortic valve stenosis (AVS), which is the most common valvular heart disease, causes a progressive narrowing of the aortic valve as a consequence of thickening and calcification of the aortic valve leaflets. The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in cardiovascular prevention have recently been demonstrated in a large randomized, controlled trial. In addition, n-3 PUFAs serve as the substrate for the synthesis of specialized proresolving mediators, which are known by their potent beneficial anti-inflammatory, proresolving, and tissue-modifying prop

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MUKANOVA, M. B., F. YU KOPYLOV, R. N. KOMAROV, et al. "Acute coronary syndrome in patients with aortic valve stenosis." Practical medicine 21, no. 2 (2023): 73–78. http://dx.doi.org/10.32000/2072-1757-2023-2-73-78.

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The purpose — to assess the acute coronary syndrome (ACS) clinical aspects in patients with aortic stenosis. Material and methods. This is a retrospective single-center study that included comparison of hospital and midterm outcomes of ACS and aortic stenosis (n = 95, divided into the following groups: group 1 — severe aortic stenosis + ACS (n = 39); group 2 — moderate aortic stenosis + ACS (n = 28); group 3 — ACS without aortic stenosis (the control group selected using «Propensity matching» method) (n = 28)). Results. Hospital mortality did not differ statistically between the groups. In gro

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Conte, Maddalena, Paolo Poggio, Maria Monti, et al. "Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance." International Journal of Molecular Sciences 25, no. 2 (2024): 1171. http://dx.doi.org/10.3390/ijms25021171.

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Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid d

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Marshafawy, Hala Al, Gehan Attia Al Sawah, Mona Hafez, et al. "Balloon Valvuloplasty of Aortic Valve Stenosis in Childhood: Midterm Results in a Children's Hospital, Mansoura University, Egypt." Clinical Medicine Insights: Cardiology 6 (January 2012): CMC.S8602. http://dx.doi.org/10.4137/cmc.s8602.

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Background Balloon valvuloplasty was established as an alternative to surgery for treatment of aortic valve stenosis in childhood. Acute complications after balloon dilatation including aortic insufficiency or early death were described. Aim of Work To analyze early outcome and midterm results of balloon aortic valvuloplasty (BAV) in Children's Hospital, Mansoura University, Egypt. Subjects and Methods Between April 2005–June 2008, all consecutive patients of age <18 years treated for aortic valve stenosis (AVS) with BAV were analyzed retrospectively. The study included 21 patients; 17 male

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Al Hageh, Cynthia, Ryan Rahy, Georges Khazen, et al. "Plasma and urine metabolomic analyses in aortic valve stenosis reveal shared and biofluid-specific changes in metabolite levels." PLOS ONE 15, no. 11 (2020): e0242019. http://dx.doi.org/10.1371/journal.pone.0242019.

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Aortic valve stenosis (AVS) is a prevalent condition among the elderly population that eventually requires aortic valve replacement. The lack of reliable biomarkers for AVS poses a challenge for its early diagnosis and the application of preventive measures. Untargeted gas chromatography mass spectrometry (GC-MS) metabolomics was applied in 46 AVS cases and 46 controls to identify plasma and urine metabolites underlying AVS risk. Multivariate data analyses were performed on pre-processed data (e.g. spectral peak alignment), in order to detect changes in metabolite levels in AVS patients and to

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HIGUCHI, Maria de Lourdes, Marilia Harumi HIGUCHI-DOS-SANTOS, Humberto PIERRI, et al. "Mycoplasma pneumoniae and Chlamydia pneumoniae in calcified nodules of aortic stenotic valves." Revista do Instituto de Medicina Tropical de São Paulo 44, no. 4 (2002): 209–12. http://dx.doi.org/10.1590/s0036-46652002000400005.

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Aortic Valve Stenosis (AVS) has been explained as an atherosclerotic process of the valve as they often exhibit inflammatory changes with infiltration of macrophages, T lymphocytes and lipid infiltration. The present study investigated whether the bacteria Chlamydia pneumoniae (CP) and Mycoplasma pneumoniae (MP), detected previously in atherosclerotic plaques, are also present in AVS. Ten valves surgically removed from patients with AVS were analyzed by immunohistochemistry, in situ hybridization, and electron microscopy. The mean and standard deviation of the percentage areas occupied by CP a

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Cruz-Vega, Itayetzin Beurini, Nydia Ávila-Vanzzini, Gertrudis Hortensia González-Gómez, Rashidi Springall, Juan C. Echeverría, and Claudia Lerma. "Dynamic Response of Heart Rate Variability to Active Standing in Aortic Valve Disease: Insights from Recurrence Quantification Analysis." Sensors 25, no. 5 (2025): 1535. https://doi.org/10.3390/s25051535.

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Introduction: Aortic valve disease (AVD) is an inflammatory, lipid infiltration and calcification disease that has been associated with changes in the conventional linear heart rate variability (HRV) indices showing a marked shift towards sympathetic predominance and a deterioration of the autonomic control. Objective: To explore the HRV dynamics in AVD patients through nonlinear methods by recurrence quantification analysis (RQA). Methods: In total, 127 subjects participated in a cross-sectional study categorized into three groups: healthy valve (HV), aortic valve sclerosis (AVSc), and aortic

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Sever, Matjaž, Samo Ribarič, and Marjan Kordaš. "Simulation of Exercise-Induced Syncope in a Heart Model with Severe Aortic Valve Stenosis." Computational and Mathematical Methods in Medicine 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/138401.

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Severe aortic valve stenosis (AVS) can cause an exercise-induced reflex syncope (RS). The precise mechanism of this syncope is not known. The changes in hemodynamics are variable, including arrhythmias and myocardial ischemia, and one of the few consistent changes is a sudden fall in systemic and pulmonary arterial pressures (suggesting a reduced vascular resistance) followed by a decline in heart rate. The contribution of the cardioinhibitory and vasodepressor components of the RS to hemodynamics was evaluated by a computer model. This lumped-parameter computer simulation was based on equival

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Abas, Istiana Hairiah, Fira Ardianti Fabanyo, Megawati Abubakar, and Fikri. "Severe Aortic Stenosis Mimicking STE-ACS at Hospital in Remote Areas: A Case Report." Cardiovascular and Cardiometabolic Journal (CCJ) 5, no. 2 (2024): 118–24. http://dx.doi.org/10.20473/ccj.v5i02.2024.118-124.

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Highlights: 1. The value of a detailed physical assessment in patients with angina pectoris is crucial, as emphasized in this report. - Background: This case highlights the need for a comprehensive and accurate physical examination in patients with angina pectoris. Case Summary: A 46-year-old man was admitted to the hospital with chest pain and anterior ST segment elevation on electrocardiogram. Given the limited drugs and equipment in remote hospitals, initial treatment for ACS was given immediately. However, no significant improvement was seen with this treatment. An echocardiogram was perfo

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Gul, Yasar Gokhan, Selcuk Alver, and Bahadir Ciftci. "A Case Report of a Pericapsular Nerve Group Block for Transcatheter Aortic Valve Implantation." A&A Practice 17, no. 12 (2023): e01743. http://dx.doi.org/10.1213/xaa.0000000000001743.

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A pericapsular nerve group (PENG) block is an interfascial plane block that targets the articular branches of the femoral and obturator nerves. PENG blocks may be used for hip, vein, and groin surgeries. Transcatheter aortic valve implantation (TAVI) is a common treatment for aortic valve stenosis (AVS). Patients who undergo TAVI tend to be at high risk due to their older age and comorbidities. A PENG block using a high volume of local anesthetics may be as effective as a lumbar plexus block. In this case report, we describe successful anesthesia management using PENG blocks in 2 patients who

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Schnabel, Christian, Anett Jannasch, Saskia Faak, Thomas Waldow, and Edmund Koch. "Imaging of aortic valve dynamics in 4D OCT." Current Directions in Biomedical Engineering 1, no. 1 (2015): 254–56. http://dx.doi.org/10.1515/cdbme-2015-0063.

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AbstractThe mechanical components of the heart, especially the valves and leaflets, are enormous stressed during lifetime. Therefore, those structures undergo different pathophysiological tissue transformations which affect cardiac output and in consequence living comfort of affected patients. These changes may lead to calcific aortic valve stenosis (AVS), the major heart valve disease in humans. The knowledge about changes of the dynamic behaviour during the course of this disease and the possibility of early stage diagnosis is of particular interest and could lead to the development of new t

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Fradejas-Sastre, Víctor, Paula Parás-Bravo, Manuel Herrero-Montes, et al. "Surgical vs. transcatheter arotic valve replacement in patients over 75 years with aortic stenosis: sociodemographic profile, clinical characteristics, quality of life and functionality." PeerJ 11 (September 20, 2023): e16102. http://dx.doi.org/10.7717/peerj.16102.

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Background Aortic valve stenosis (AVS) affects 25% of the population over 65 years. At present, there is no curative medical treatment for AVS and therefore the surgical approach, consisting of transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR), is the treatment of choice. Methodology The aim of this study was to analyze the sociodemographic and clinical characteristics, quality of life and functionality of a sample of patients with AVS over 75 years of age, who underwent TAVR or SAVR, applying standard clinical practice. A prospective multicenter observa

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Perrone, M. A., F. G. Viola, M. Minieri, et al. "The Von Willebrand Factor Antigen Plasma Concentration: a Monitoring Marker in the Treatment of Aortic and Mitral Valve Diseases." Folia Biologica 66, no. 4 (2020): 133–41. http://dx.doi.org/10.14712/fb2020066040133.

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Von Willebrand disease is a commonly inherited bleeding disorder caused by defects of von Willebrand factor (vWF). In the most common valve diseases, aortic valve stenosis (AVS) and mitral valve regurgitation (MVR), a bleeding tendency has been described in a number of patients. This has been associated to a high turbulence of blood flow through the compromised valve, promoting degradation of vWF with loss of high-molecular-weight multimers of vWF (HMWM), leading to an acquired von Willebrand syndrome (AvWS). We analysed three groups of patients, one affected by AVS, treated with transcatheter

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Mühlenbruch, G., J. E. Wildberger, R. Koos, et al. "Calcium scoring of aortic valve calcification in aortic valve stenosis with a multislice computed tomography scanner: non-enhanced versus contrast-enhanced studies." Acta Radiologica 46, no. 6 (2005): 561–66. http://dx.doi.org/10.1080/02841850510021698.

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Purpose: Previous studies have shown a positive correlation between amount of aortic valve calcification (AVC) and degree of aortic valve stenosis (AVS). We have investigated whether calcium scoring of AVC from contrast-enhanced images is reliable. Material and Methods: Nineteen patients with suspected AVS underwent retrospectively ECG-gated multislice computed tomography (MSCT). Standardized scan protocols were applied prior to (120 KV, 133 mAseff) and after (120 KV, 500 mAseff) the administration of non-ionic contrast material. Image reconstruction was performed at 60% of the RR interval (sl

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Foffa, Ilenia, Augusto Esposito, Ludovica Simonini, Sergio Berti, and Cecilia Vecoli. "Telomere Length and Clonal Hematopoiesis of Indeterminate Potential: A Loop Between Two Key Players in Aortic Valve Disease?" Journal of Cardiovascular Development and Disease 12, no. 4 (2025): 135. https://doi.org/10.3390/jcdd12040135.

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Aortic valve stenosis (AVS) is the most common valvular heart disease that was considered, for a long time, a passive degenerative disease due to physiological aging. More recently, it has been recognized as an active, modifiable disease in which many cellular processes are involved. Nevertheless, since aging remains the major risk factor for AVS, a field of research has focused on the role of early (biological) aging and its dependent pathways in the initiation and progression of AVS. Telomeres are regions at the ends of chromosomes that are critical for maintaining genome stability in eukary

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Youssef, Ali, Mustafa Alrefae, and Sayed Abouelsoud. "Spontaneous regression of severe aortic stenosis after massive embolization in a patient with antiphospholipid syndrome." Seminars in Cardiovascular Medicine 25, no. 1 (2019): 4–8. http://dx.doi.org/10.2478/semcard-2019-0002.

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Summary We present a case of probably unreported aortic stenosis evolution in a patient with primary antiphospholipid syndrome (APS). A female patient, 54 years old, with a history of recurrent deep venous thrombosis, an episode of pulmonary embolism and was positive for APS antibodies. She was kept on warfarin and aspirin. The patient was admitted with acute pulmonary edema and severe aortic stenosis. While preparing for aortic valve surgery, the patient developed acute stroke, and a week later developed concurrent acute ischemia of both lower limbs. Emergency surgery salvaged the lower limbs

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Huang, Ninghao, Zhenhuang Zhuang, Zhonghua Liu, and Tao Huang. "Observational and Genetic Associations of Modifiable Risk Factors with Aortic Valve Stenosis: A Prospective Cohort Study of 0.5 Million Participants." Nutrients 14, no. 11 (2022): 2273. http://dx.doi.org/10.3390/nu14112273.

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Background: Observational studies have shown that modifiable risk factors are associated with aortic valve stenosis (AVS). However, the causality behind these associations remains largely unknown. Objectives: To explore the associations of modifiable risk factors, including metabolic factors, biochemical measures, education, and lifestyles with AVS and their potential causal associations. Methods: We enrolled 361,930 British white people with genetic data in the UK biobank. Cox proportional risk regression models were used to estimate the hazard ratios between 28 modifiable risk factors and AV

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Aguado, Brian A., Katherine B. Schuetze, Joseph C. Grim, et al. "Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation." Science Translational Medicine 11, no. 509 (2019): eaav3233. http://dx.doi.org/10.1126/scitranslmed.aav3233.

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The transcatheter aortic valve replacement (TAVR) procedure has emerged as a minimally invasive treatment for patients with aortic valve stenosis (AVS). However, alterations in serum factor composition and biological activity after TAVR remain unknown. Here, we quantified the systemic inflammatory effects of the TAVR procedure and hypothesized that alterations in serum factor composition would modulate valve and cardiac fibrosis. Serum samples were obtained from patients with AVS immediately before their TAVR procedure (pre-TAVR) and about 1 month afterward (post-TAVR). Aptamer-based proteomic

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Yasuhara, Jun, Karlee Schultz, Amee M. Bigelow, and Vidu Garg. "Congenital aortic valve stenosis: from pathophysiology to molecular genetics and the need for novel therapeutics." Frontiers in Cardiovascular Medicine 10 (April 28, 2023). http://dx.doi.org/10.3389/fcvm.2023.1142707.

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Congenital aortic valve stenosis (AVS) is one of the most common valve anomalies and accounts for 3%–6% of cardiac malformations. As congenital AVS is often progressive, many patients, both children and adults, require transcatheter or surgical intervention throughout their lives. While the mechanisms of degenerative aortic valve disease in the adult population are partially described, the pathophysiology of adult AVS is different from congenital AVS in children as epigenetic and environmental risk factors play a significant role in manifestations of aortic valve disease in adults. Despite inc

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Wen, Dezhong, Li Hu, Jianggui Shan, et al. "Mechanical injury accentuates lipid deposition in ApoE–/– mice and advance aortic valve stenosis: A novel modified aortic valve stenosis model." Frontiers in Cardiovascular Medicine 10 (February 2, 2023). http://dx.doi.org/10.3389/fcvm.2023.1119746.

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BackgroundCurrent mouse models still have limitations in studying aortic valve stenosis (AVS). A suitable animal model bearing a close resemblance to the pathophysiological processes of humans needs to be developed. Here, we combined two risk factors to create a mouse model that mimics the pathological features of human AVS.Methods and resultsWe combined WI and hyperlipidemia in ApoE–/– mice to explore the synergistic effect on the stenosis of the aortic valve. Transthoracic echocardiography revealed progressively increased peak velocity with age in ApoE–/– mice to velocities above C57 mice wh

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Goody, P. R., D. Christmann, M. R. Hosen, et al. "The role of noncoding RNAs during aortic valve stenosis." European Heart Journal 41, Supplement_2 (2020). http://dx.doi.org/10.1093/ehjci/ehaa946.1870.

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Abstract Background Aortic valve stenosis (AVS) is the most common valve disease worldwide. Thought to be a purely degenerative disease, it is now clear that shear stress/endothelial dysfunction, lipid deposition and inflammation lead to calcification and stenosis of the valve. There is evidence, that extracellular vesicles (EVs) are actively involved in calcification processes. Practically all cells, including endothelial cells, can generate EVs, which can be shed into the blood stream and into the interstitial space. EVs contain lipids, proteins and nucleic acids, including noncoding RNAs (n

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Rahaman, Suneha G., Bidisha Dutta, and Shaik O. Rahaman. "Transient receptor potential vanilloid 4 calcium channel contributes to valve stiffening in aortic stenosis." Physiology 40, S1 (2025). https://doi.org/10.1152/physiol.2025.40.s1.0022.

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Aortic valve stenosis (AVS) is a progressive disease characterized by fibrosis, inflammation, calcification, and stiffening of the aortic valve leaflets, which leads to impaired blood flow and left ventricular pressure overload. If left untreated, symptomatic AVS can result in heart failure and death within 2 to 5 years. Understanding the molecular mechanisms driving AVS is critical for developing noninvasive therapies. Emerging evidence suggests that extracellular and intracellular matrix stiffness influences gene expression, inflammation, and cell differentiation, with myofibroblast activati

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Cayer, Lucien G. J., Arun Surendran, Tobias Karakach, Harold M. Aukema, and Amir Ravandi. "Valvular Prostaglandins Are Elevated in Severe Human Aortic Valve Stenosis." Arteriosclerosis, Thrombosis, and Vascular Biology, February 15, 2024. http://dx.doi.org/10.1161/atvbaha.123.320001.

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BACKGROUND: Aortic valve stenosis (AVS) is the most common valvular disease in the developed world. AVS involves the progressive fibrocalcific remodeling of the aortic valve (AV), which impairs function and can ultimately lead to heart failure. Due to gaps in our understanding of the underlying mechanisms of AVS, there are no pharmacological treatments or dietary interventions known to slow AVS progression. Recent studies have begun to suggest oxylipins—a class of bioactive lipids—may be dysregulated in the valves of patients with AVS. METHODS: We utilized high-performance liquid chromatograph

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Winnicki, Anna, James Gadd, Vahagn A. Ohanyan, et al. "Abstract 14024: Role of Endothelial CXCR4 on the Development of Aortic Valve Stenosis." Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.14024.

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Background. CXCL12/CXCR4 signaling is essential in cardiac development and repair, however, its contribution to the Aortic valve stenosis (AVS) remains unclear. In this study, we tested the role of endothelial CXCR4 on the development of AVS. Methods. We generated CXCR4 endothelial cell-specific knockout mice (EC CXCR4 KO) by crossing CXCR4 fl/fl mouse with Tie2-Cre mouse to study the role of endothelial cell CXCR4 in AVS. CXCR4 fl/fl mice with no Tie2-Cre gene present were used as control. Echocardiography was used to assess the aortic valve and cardiac function. Heart samples containing the

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Rao, P. Syamasundar. "Pictorial rendition of author’s observations on balloon valvuloplasty/angioplasty procedures: Aortic stenosis." Brain & Heart, July 25, 2024, 2914. http://dx.doi.org/10.36922/bh.2914.

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Balloon aortic valvuloplasty (BAV) effectively decreases peak pressure gradients through the aortic valve both at the time of the procedure and during follow-up. This paper presents the author&rsquo;s observations on the utility of BAV in treating congenital aortic valve stenosis (AVS). Previous work by the author noted intermediate-term restenosis and late-onset aortic insufficiency (AI). Factors contributing to restenosis include age under 3 years and post-balloon residual aortic valve gradients exceeding 30 mmHg. Repeat balloon valvuloplasty has been found to address restenosis effectiv

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Billig, H., J. Schmitt, L. Singer, et al. "The impact of postmenopausal osteoporosis on aortic valve stenosis in an animal model." European Heart Journal 44, Supplement_2 (2023). http://dx.doi.org/10.1093/eurheartj/ehad655.3205.

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Abstract Background Aortic valve stenosis (AVS) is the most prevalent heart valve disease worldwide and mainly affects the elderly. In observational clinical studies, postmenopausal osteoporosis, which affects 30 % of all women, is associated with increased aortic valve calcification and stenosis. However, there are no pathomechanistic investigations that link these diseases. In this study, we analyzed the impact of postmenopausal osteoporosis in ovariectomized C57BL6/J mice on the occurrence and progression of wire injury-induced aortic valve stenosis. Methods To induce postmenopausal osteopo

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Vogt, Brandon James, Doug K. Peters, Kristi S. Anseth, and Brian A. Aguado. "Inflammatory serum factors from aortic valve stenosis patients modulate sex differences in valvular myofibroblast activation and osteoblast-like differentiation." Biomaterials Science, 2022. http://dx.doi.org/10.1039/d2bm00844k.

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Aortic valve stenosis (AVS) is a sexually dimorphic cardiovascular disease that is driven by fibrosis and, often, eventual calcification of the aortic valve leaflets. Circulating inflammatory factors present in serum...

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