Relevant bibliographies by topics / APEX1

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'APEX1'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "APEX1"

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Liao, Chengcheng, Srikanth Talluri, Subodh Kumar, et al. "Base Excision Repair and Homologous Recombination Pathway Intermediates Drive Genomic Instability and Evolution in Myeloma." Blood 136, Supplement 1 (2020): 27–28. http://dx.doi.org/10.1182/blood-2020-141042.

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Multiple myeloma (MM) cells demonstrate significant genomic instability with acquisition of new genomic events over time. In an effort to decipher the pathways utilized by MM cells to genomically evolve and to acquire proliferative advantage as well as develop drug resistance, we have investigated role of various pathway intermediates. Based on our prior results showing elevated homologous recombination (HR) contributing to genomic instability and development of drug resistance, we have further studied RAD51, the key HR gene. Also based on the dysfunctional base excision repair (BER) that can
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Shammas, Masood, Jagannath Pal, Ankit V. Vahia, et al. "Elevated APEX1 Endonuclease Is Associated with Increased DNA Breaks and Instability in Myeloma." Blood 118, no. 21 (2011): 1805. http://dx.doi.org/10.1182/blood.v118.21.1805.1805.

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Abstract Abstract 1805 Exposure to DNA-damaging agents of both endogenous and exogenous origin, including ultraviolet (UV) radiation, give rise to apurinic/apyrimidinic (AP) or abasic sites in genome, probably the most common mutagenic DNA lesions. APEX1, the key protein involved in the repair of AP sites through base excision repair, plays an important role in the maintenance of genomic integrity. We have observed that APEX1 is overexpressed in multiple myeloma (MM) cell lines and primary cells. To evaluate its functional role MM cells were transduced with control (CS) or APEX1-specific lenti
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Tummanatsakun, Doungdean, Tanakorn Proungvitaya, Sittiruk Roytrakul, and Siriporn Proungvitaya. "Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells." Molecules 26, no. 9 (2021): 2587. http://dx.doi.org/10.3390/molecules26092587.

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Apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1) is involved in the DNA damage repair pathways and associates with the metastasis of several human cancers. However, the signaling pathway of APEX1 in cholangiocarcinoma (CCA) has never been reported. In this study, to predict the signaling pathways of APEX1 and related proteins and their functions, the effects of APEX1 gene silencing on APEX1 and related protein expression in CCA cell lines were investigated using mass spectrometry and bioinformatics tools. Bioinformatic analyses predicted that APEX1 might interact with cell division cycle
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Kim, Yeo, Lim, Song, Chun, and Kim. "APEX1 Expression as a Potential Diagnostic Biomarker of Clear Cell Renal Cell Carcinoma and Hepatobiliary Carcinomas." Journal of Clinical Medicine 8, no. 8 (2019): 1151. http://dx.doi.org/10.3390/jcm8081151.

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Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APEX1) has been known to play key roles in DNA repair, the regulation of diverse transcriptional activity, and cellular responses to redox activity. This study aimed to examine serum APEX1 (s-APEX1) expression as a possible screening biomarker for clear cell renal cell carcinoma (ccRCC), hepatocellular carcinoma (HCC), and proximal and distal cholangiocarcinoma (CC). A total of 216 frozen serum samples were collected from 39 healthy control cases, 32 patients with ≥58 copies/mL of hepatitis B viral DNA (HBV DNA (+)), 40 ccRCC cases,
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Li, Yuan, Zili Xu, Xiangyang Liu, Xiandong Peng, Shu Cao, and Zhulin Yang. "Analysis of Variance Based Significance Analysis of Cartilage Tumor." Journal of Medical Imaging and Health Informatics 10, no. 9 (2020): 1985–91. http://dx.doi.org/10.1166/jmihi.2020.3121.

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Chondrosarcoma is a malignant bone tumor with poor prognosis. Surgical treatment is the first choice for chondrosarcomas. Chondrosarcoma is not sensitive to chemotherapy and radiotherapy. Identification of biological markers is important for the early diagnosis and targeted treatment of chondrosarcoma. This study aimed to investigate the protein expression and clinicopathological significance of APEX1 and Haptoglobin in 85 chondrosarcomas and 38 osteochondromas based on deep learning. The APEX1 and Haptoglobin protein expression in tissues was measured by immunohistochemistry. The percentage o
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Kumar, Subodh, Srikanth Talluri, Mariateresa Fulciniti, Masood A. Shammas, and Nikhil C. Munshi. "Elevated APEX1 Disrupts G2/M Checkpoint, Contributing to Evolution and Survival of Myeloma Cells." Blood 126, no. 23 (2015): 2997. http://dx.doi.org/10.1182/blood.v126.23.2997.2997.

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Abstract Cell cycle checkpoints provide the cell with time to repair chromosomal DNA damage before its replication (G1) and also prior to its segregation (G2), thus ensuring integrity, maintenance and protection of genome. Although proper functioning of both checkpoints is essential, G2/M has a special significance as a potentially lethal double-strand break in DNA escape repair and persist from G2 into mitosis, it may recombine in G1 to produce gene rearrangements. Moreover, G2 is the phase where homologous recombination (HR) can utilize a sister chromatid as a template to provide error-free
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Tummanatsakun, Doungdean, Tanakorn Proungvitaya, Sittiruk Roytrakul, et al. "Serum Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) Level as a Potential Biomarker of Cholangiocarcinoma." Biomolecules 9, no. 9 (2019): 413. http://dx.doi.org/10.3390/biom9090413.

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Diagnostic and/or prognostic biomarkers for cholangiocarcinoma (CCA) are still insufficient with poor prognosis of patients. To discover a new CCA biomarker, we constructed our secretome database of three CCA cell lines and one control cholangiocyte cell line using GeLC-MS/MS. We selected candidate proteins by five bioinformatics tools for secretome analysis. The inclusion criteria were as follows: having predicted signal peptide or being predicted as non-classically secreted protein; together with having no transmembrane helix and being previously detected in plasma and having the highest num
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Kim, Daria V., Liliya M. Kulishova, Natalia A. Torgasheva, et al. "Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line." PLOS ONE 16, no. 9 (2021): e0257473. http://dx.doi.org/10.1371/journal.pone.0257473.

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The major human apurinic/apyrimidinic (AP) site endonuclease, APEX1, is a central player in the base excision DNA repair (BER) pathway and has a role in the regulation of DNA binding by transcription factors. In vertebrates, APEX1 knockouts are embryonic lethal, and only a handful of knockout cell lines are known. To facilitate studies of multiple functions of this protein in human cells, we have used the CRISPR/Cas9 system to knock out the APEX1 gene in a widely used non-cancer hypotriploid HEK 293FT cell line. Two stable knockout lines were obtained, one carrying two single-base deletion all
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Lin, Jianhong, Chun Yang, Ariel Kwart, et al. "Apurinic/Apyrimidinic Endonuclease 1 Induced Genomic Instability Causes T-Cell Acute Lymphoblastic Leukemia in Zebrafish." Blood 126, no. 23 (2015): 1431. http://dx.doi.org/10.1182/blood.v126.23.1431.1431.

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Abstract Genomic instability is not only a hallmark of cancer, but potentially a primary mechanism for its occurrence. DNA repair mechanisms play a protective role during DNA damage induced by both normal metabolic activities and environmental factors such as reactive oxygen species (ROS), UV light and γ-irradiation. Genes related to DNA repair are usually considered as tumor suppressors. However, incomplete repair may induce severe genomic instability, leading eventually to transformation. Apurinic/apyrimidinic endonuclease 1 (APEX1), a gene involved in DNA repair with an important role in th
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Merk, Dennis, Johannes Ptok, Philipp Jakobs, et al. "Selenoprotein T Protects Endothelial Cells against Lipopolysaccharide-Induced Activation and Apoptosis." Antioxidants 10, no. 9 (2021): 1427. http://dx.doi.org/10.3390/antiox10091427.

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Sepsis is an exaggerated immune response upon infection with lipopolysaccharide (LPS) as the main causative agent. LPS-induced activation and apoptosis of endothelial cells (EC) can lead to organ dysfunction and finally organ failure. We previously demonstrated that the first twenty amino acids of the Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) are sufficient to inhibit EC apoptosis. To identify genes whose regulation by LPS is affected by this N-terminal APEX1 peptide, EC were transduced with an expression vector for the APEX1 peptide or an empty control vector and treated with LPS.
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Dissertations / Theses on the topic "APEX1"

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Kuasne, Hellen. "Investigação dos genes APEX1, XRCC1, PSA e AR como candidatos a marcadores moleculares para o câncer de próstata." UEL, IAPAR, EMBRAPA. Centro de Ciências Biológicas. Programa de Pós-Graduação em Genética e Biologia Molecular, 2009. http://www.bibliotecadigital.uel.br/document/?code=vtls000157963.

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O câncer de próstata é o segundo tipo de câncer mais incidente no Brasil. Dentre os genes de interesse relacionados com esta neoplasia, destacam-se os participantes da via dos andrógenos, como o Receptor de Andrógeno (AR), o Antígeno Específico da Próstata (PSA) e os da via de reparo a danos no DNA (APEX1 e XRCC1). Polimorfismos nesses genes são freqüentes na população, podendo levar a alterações das atividades gênicas e contribuir para o risco de desenvolvimento e progressão do tumor. O objetivo deste trabalho foi analisar as freqüências dos genótipos prevalentes, heterozigotos e raros dos ge
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Ferreira, Stef?nia Jer?nimo. "Avalia??o de polimorfismos funcionais nos genes de reparo XRCC1, APEX1, XPD e XPF em carcinomas de c?lulas escamosas orais." Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/19914.

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Fontes, Fabr?cia Lima. "Marcadores gen?ticos associados com a resposta inflamat?ria na meningite bacteriana." Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13394.

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Made available in DSpace on 2014-12-17T14:14:00Z (GMT). No. of bitstreams: 1 FabriciaLF_DISSERT.pdf: 3549779 bytes, checksum: 2364a7c4e80831b956545a9a31de3525 (MD5) Previous issue date: 2012-11-19<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>A meningite bacteriana (MB) ? uma doen?a infecto-contagiosa que apresenta altas taxas de mortalidade e morbidade, constituindo-se assim um grave problema de sa?de p?blica. ? caracterizada por uma intensa inflama??o granuloc?tica que leva a inj?ria neuronal e consequentemente surgimento de sequelas neurol?gicas. A resposta inflamat?ri
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Bernecky, Robert. "APEX, the APL parallel executor." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq28764.pdf.

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Han, Yisu Ph D. Massachusetts Institute of Technology. "Directed evolution of split APEX peroxidase." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/120907.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>APEX is an engineered peroxidase that catalyzes the oxidation of a wide range of substrates, facilitating its use in a variety of applications, from subcellular staining for electron microscopy to proximity biotinylation for spatially restricted proteomics and transcriptomics. While this strategy has provided access to many cellular regions and organelles, there are still many compartments and structures that cannot be accesse
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Zuniga, David. "Flood dynamics, hazard and risks in an active alluvial fan system threatening Ciudad Juàrez Chihuahua Mexico." Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/13049.

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The aim of this research is to assess hazards and risks associated with flooding in the city of Juárez, northern México, where there is a flood threat from active alluvial fans from mountains to the southwest and from the Rio Grande (Bravo River) to the northwest forming the northeast border of the city. Aims of this Ph.D. were addressed processing a digital elevation model (DEM) of the study area in a GIS platform to define the several alluvial fans, and thus to examine their history and palaeohydrology. Three OSL dates in the youngest parts of the fans show ages ranging from 74 - 31 ka. Howe
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Rounds, Richard Grafton. "Metaphoric reconstruction : an addition to the APEX museum." Thesis, Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/21700.

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de, Graaf Niels. "Simulation of Attitude and Orbit Control for APEX CubeSat." Thesis, Luleå tekniska universitet, Rymdteknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-80736.

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CubeSats are becoming a game changer in the space industry. Appearing first for univer-sity mission, its popularity is increasing for commercial use and for deep space missionssuch as the on HERA mission that will orbit in 2026 around an asteroid as part of aplanetary defence mission. Standardisation and industrial collaboration is key to a fastdevelopment, assuring the product quality and lower development expenditures.In this study the focus is set elaborating a low cost demonstrator platform to be usedfor developing and testing onboard software on physical hardware: a Hardware-Softwaretesti
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Tiraboschi, Lisa A. "A survey of characteristics and attitudes of offices currently and previously participating in the APEX program." Thesis, Boston University, 1992. https://hdl.handle.net/2144/37821.

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Thesis (M.Sc.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1992 (Dental Public Health).<br>Includes bibliographical references: (leaves 37-39).<br>Changes in the external environment and the dental needs of the public have placed greater demands on dental schools to graduate dentists better prepared to enter dental practice. New disease patterns, an aging population, and technological advancements, as well as, rising tuition and a decline in the applicant pool, are factors which are forcing dental educators to re-evaluate the curriculum and create new methods in which de
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Kennedy, James 1983. "The APEX-SZ experiment : observations of the Sunyaev Zel'dovich effect." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116109.

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The Sunyaev Zel'dovich effect (SZE) is a secondary distortion of the cosmic microwave background (CMB) spectrum produced by galaxy clusters that allows for measurements of intra-cluster gas properties. Current experiments are using large arrays of multiplexed transition-edge sensor bolometers to achieve the sensitivities required for SZE cluster surveys and targeted cluster SZE observations. This thesis describes the APEX-SZ experiment, the first instrument to produce scientific results from observations with such an array. The scientific motivation for the APEX-SZ experiment is discussed, fol
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Books on the topic "APEX1"

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Monahan, Sherry. Apex. Arcadia Pub., 2009.

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Apex. Hyperion Books, 2017.

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malacologie, Société belge de. Apex. La Société, 1986.

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Monahan, Sherry. Apex. Arcadia Pub., 2009.

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Nelson-Saginor, Page. Apex: Poems. Hetaira Press, 1998.

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Anderson, M. T. Apex predator. Scholastic, Incorporated, 2018.

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contributor, Siemers Troy, Heinold Brian 1977 contributor, Chalishajar Dimplekumar contributor, and Bowen, Jennifer (Jennifer Lynne), editor, eds. APEX calculus. 3rd ed. Gregory Hartman, 2015.

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Nuijten, A. Oracle APEX Best Practices. Packt Publishing, Limited, 2012.

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Whitehead, Colson. Apex hides the hurt. Doubleday, 2006.

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Whitehead, Colson. Apex hides the hurt. Thorndike Press, 2006.

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Book chapters on the topic "APEX1"

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Cimolini, Patrick, and Karen Cannell. "Core APEX vs. Enhanced APEX." In Agile Oracle Application Express. Apress, 2012. http://dx.doi.org/10.1007/978-1-4302-3760-0_3.

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Gundabattula, Ananth, and Thomas Weise. "Apache Apex." In Encyclopedia of Big Data Technologies. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-77525-8_316.

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Gundabattula, Ananth, and Thomas Weise. "Apache Apex." In Encyclopedia of Big Data Technologies. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-63962-8_316-1.

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Zegers, Tanja. "Apex Chert." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_280-3.

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Zegers, Tanja Elsa. "Apex Chert." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_280.

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Fox, Tim, John Edward Scott, and Scott Spendolini. "APEX Dictionary." In Pro Oracle Application Express 4. Apress, 2011. http://dx.doi.org/10.1007/978-1-4302-3495-1_16.

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Spendolini, Scott. "APEX Architecture." In Expert Oracle Application Express Security. Apress, 2013. http://dx.doi.org/10.1007/978-1-4302-4732-6_3.

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Zegers, Tanja. "Apex Chert." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_280.

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Mignault, Francis, and Luc Demanche. "About APEX." In Oracle Application Express Administration. Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-1958-4_1.

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Jun, Bokkwan, and Neil R. Miller. "Orbital Apex Inflammation." In Emergencies of the Orbit and Adnexa. Springer India, 2016. http://dx.doi.org/10.1007/978-81-322-1807-4_24.

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Conference papers on the topic "APEX1"

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Britt, Michael. "APEX1, a library of dynamic programming examples." In the twentieth SIGCSE technical symposium. ACM Press, 1989. http://dx.doi.org/10.1145/65293.71196.

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Grun, Peter, Nikil Dutt, and Alex Nicolau. "APEX." In the 14th international symposium. ACM Press, 2001. http://dx.doi.org/10.1145/500001.500007.

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Chung, Chin-Wan, Jun-Ki Min, and Kyuseok Shim. "APEX." In the 2002 ACM SIGMOD international conference. ACM Press, 2002. http://dx.doi.org/10.1145/564691.564706.

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Simske, Steven J., and Helen Balinsky. "APEX." In the 10th ACM symposium. ACM Press, 2010. http://dx.doi.org/10.1145/1860559.1860587.

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Nauman, Mohammad, Sohail Khan, and Xinwen Zhang. "Apex." In the 5th ACM Symposium. ACM Press, 2010. http://dx.doi.org/10.1145/1755688.1755732.

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Zhou, Qian, and Fan Ye. "APEX." In IoTDI '19: International Conference on Internet-of-Things Design and Implementation. ACM, 2019. http://dx.doi.org/10.1145/3302505.3310066.

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Ge, Chang, Xi He, Ihab F. Ilyas, and Ashwin Machanavajjhala. "APEx." In SIGMOD/PODS '19: International Conference on Management of Data. ACM, 2019. http://dx.doi.org/10.1145/3299869.3300092.

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Metsch, Thijs, Olumuyiwa Ibidunmoye, Victor Bayon-Molino, Joe Butler, Francisco Hernández-Rodriguez, and Erik Elmroth. "Apex Lake." In Middleware '15: 16th International Middleware Conference. ACM, 2015. http://dx.doi.org/10.1145/2830013.2830016.

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Hueni, A., S. Sterckx, and M. Jehle. "Operational calibration of APEX." In IGARSS 2013 - 2013 IEEE International Geoscience and Remote Sensing Symposium. IEEE, 2013. http://dx.doi.org/10.1109/igarss.2013.6723816.

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Hueni, A., S. Sterckx, M. Jehle, et al. "Operational status of apex and characteristics of the apex open science data set." In IGARSS 2012 - 2012 IEEE International Geoscience and Remote Sensing Symposium. IEEE, 2012. http://dx.doi.org/10.1109/igarss.2012.6352486.

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Reports on the topic "APEX1"

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SCHAFER CORP ARLINGTON VA. APEX Support. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada361665.

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Ahmad, I., B. B. Back, and R. R. Betts. Monte Carlo studies of APEX. Office of Scientific and Technical Information (OSTI), 1995. http://dx.doi.org/10.2172/166360.

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Ahmad, I., B. B. Back, and R. R. Betts. Improvements to the APEX apparatus. Office of Scientific and Technical Information (OSTI), 1995. http://dx.doi.org/10.2172/166373.

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Rose, M., G. Klyne, and D. Crocker. The Application Exchange (APEX) Access Service. RFC Editor, 2002. http://dx.doi.org/10.17487/rfc3341.

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Rose, M., G. Klyne, and D. Crocker. The Application Exchange (APEX) Presence Service. RFC Editor, 2003. http://dx.doi.org/10.17487/rfc3343.

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Hammond, Simon David. Towards Accurate Application Characterization for Exascale (APEX). Office of Scientific and Technical Information (OSTI), 2015. http://dx.doi.org/10.2172/1221578.

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McNeil, W. J. Simulation and Calculation of the APEX Attitude. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada258716.

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Blower, D. J. Psychometric Equivalency Issues for the APEX System. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada350727.

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Smith, Curtis Lee. Information on the Advanced Plant Experiment (APEX) Test Facility. Office of Scientific and Technical Information (OSTI), 2015. http://dx.doi.org/10.2172/1369620.

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Dixon, E., H. Franklin, J. Kint, et al. The Application Exchange (APEX) Option Party Pack, Part Deux! RFC Editor, 2002. http://dx.doi.org/10.17487/rfc3342.

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