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Relevant bibliographies by topics / Aphidicolin

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Academic literature on the topic 'Aphidicolin'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Aphidicolin"

1

Kayser, O., A. F. Kiderlen, S. Bertels, and K. Siems. "Antileishmanial Activities of Aphidicolin and Its Semisynthetic Derivatives." Antimicrobial Agents and Chemotherapy 45, no. 1 (2001): 288–92. http://dx.doi.org/10.1128/aac.45.1.288-292.2001.

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ABSTRACT Aphidicolin and a series of semisynthetic aphidicolan derivatives have been identified in in vitro tests as novel drugs with antiparasitic potential. All compounds have been tested against extracellular promastigotes of Leishmania donovani,L. infantum, L. enriettii, and L. major and against intracellular amastigotes of L. donovani in murine macrophages. The compounds showed antileishmanial activity at concentrations in the microgram range (50% effective concentration [EC50] = 0.02 to 1.83 μg/ml). The most active derivative (aphidicolin-17-glycinate hydrochloride) had EC50s of 0.2 μg/m

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2

Hanson, James R. "Aphidicolin: Its Chemistry and Biosynthesis." Journal of Chemical Research 42, no. 8 (2018): 395–401. http://dx.doi.org/10.3184/174751918x15333061990467.

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1. Introduction 2. Naturally occurring aphidicolanes 3. The chemistry of aphidicolin 4. Synthesis 5. Biosynthesis 6. References The occurrence and structure of the biologically active tetracyclic diterpenoid aphidicolin and related aphidicolane natural products, together with their chemistry, their molecular rearrangements and their biosynthesis, are reviewed.

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3

Lupi, Alessandro, Maria Patamia, and Rinaldo Marini Bettole. "A Total Synthesis of (�)- Aphidicolin: Regio- and stereoselective conversion of 3?,18-Di-O-benzyl-17-nor-14-aphidicolen-16-one into (�)-aphidicolin." Helvetica Chimica Acta 71, no. 4 (1988): 872–75. http://dx.doi.org/10.1002/hlca.19880710423.

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4

Toyota, Masahiro, Youichi Nishikawa, and Keiichiro Fukumoto. "Aphidicolin synthesis (II)—an expeditious and efficient formal synthesis of (±)-aphidicolin." Tetrahedron 50, no. 38 (1994): 11153–66. http://dx.doi.org/10.1016/s0040-4020(01)89418-7.

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Hunting, Darel J., Bonnie J. Gowans, and Steven L. Dresler. "DNA polymerase delta mediates excision repair in growing cells damaged with ultraviolet radiation." Biochemistry and Cell Biology 69, no. 4 (1991): 303–8. http://dx.doi.org/10.1139/o91-046.

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In confluent, stationary phase cells, an aphidicolin-sensitive DNA polymerase mediates UV-induced excision repair, but the situation in growing cells is still controversial. The sensitivity of repair synthesis to aphidicolin, an inhibitor of DNA polymerases alpha and delta, was determined in growth phase and confluent normal human fibroblasts (AG1518) using several techniques. Repair synthesis in confluent cells was always inhibited by aphidicolin, no matter which measurement technique was used. However, the inhibition of repair synthesis in growth-phase cells by aphidicolin was only detectabl

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6

Decker, R. S., M. Yamaguchi, R. Possenti, and M. L. DePamphilis. "Initiation of simian virus 40 DNA replication in vitro: aphidicolin causes accumulation of early-replicating intermediates and allows determination of the initial direction of DNA synthesis." Molecular and Cellular Biology 6, no. 11 (1986): 3815–25. http://dx.doi.org/10.1128/mcb.6.11.3815.

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Aphidicolin, a specific inhibitor of DNA polymerase alpha, provided a novel method for distinguishing between initiation of DNA synthesis at the simian virus 40 (SV40) origin of replication (ori) and continuation of replication beyond ori. In the presence of sufficient aphidicolin to inhibit total DNA synthesis by 50%, initiation of DNA replication in SV40 chromosomes or ori-containing plasmids continued in vitro, whereas DNA synthesis in the bulk of SV40 replicative intermediate DNA (RI) that had initiated replication in vivo was rapidly inhibited. This resulted in accumulation of early RI in

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Decker, R. S., M. Yamaguchi, R. Possenti, and M. L. DePamphilis. "Initiation of simian virus 40 DNA replication in vitro: aphidicolin causes accumulation of early-replicating intermediates and allows determination of the initial direction of DNA synthesis." Molecular and Cellular Biology 6, no. 11 (1986): 3815–25. http://dx.doi.org/10.1128/mcb.6.11.3815-3825.1986.

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Aphidicolin, a specific inhibitor of DNA polymerase alpha, provided a novel method for distinguishing between initiation of DNA synthesis at the simian virus 40 (SV40) origin of replication (ori) and continuation of replication beyond ori. In the presence of sufficient aphidicolin to inhibit total DNA synthesis by 50%, initiation of DNA replication in SV40 chromosomes or ori-containing plasmids continued in vitro, whereas DNA synthesis in the bulk of SV40 replicative intermediate DNA (RI) that had initiated replication in vivo was rapidly inhibited. This resulted in accumulation of early RI in

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8

Sherwood, S. W., R. I. Schumacher, and R. T. Schimke. "Effect of cycloheximide on development of methotrexate resistance of Chinese hamster ovary cells treated with inhibitors of DNA synthesis." Molecular and Cellular Biology 8, no. 7 (1988): 2822–27. http://dx.doi.org/10.1128/mcb.8.7.2822.

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We examined the effects of 18 h of incubation of Chinese hamster ovary (CHO K1) cells with cycloheximide, hydroxyurea, and aphidicolin. Treatment of cells with cycloheximide alone at a concentration adequate to inhibit DNA synthesis to less than 10% of control was significantly less cytotoxic and clastogenic than treatment with hydroxyurea or aphidicolin, did not induce unbalanced cellular growth, and had no effect on the frequency of resistant cells in methotrexate selections compared with control cells. When combined with hydroxyurea or aphidicolin and compared with the effects of either dru

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Sherwood, S. W., R. I. Schumacher, and R. T. Schimke. "Effect of cycloheximide on development of methotrexate resistance of Chinese hamster ovary cells treated with inhibitors of DNA synthesis." Molecular and Cellular Biology 8, no. 7 (1988): 2822–27. http://dx.doi.org/10.1128/mcb.8.7.2822-2827.1988.

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We examined the effects of 18 h of incubation of Chinese hamster ovary (CHO K1) cells with cycloheximide, hydroxyurea, and aphidicolin. Treatment of cells with cycloheximide alone at a concentration adequate to inhibit DNA synthesis to less than 10% of control was significantly less cytotoxic and clastogenic than treatment with hydroxyurea or aphidicolin, did not induce unbalanced cellular growth, and had no effect on the frequency of resistant cells in methotrexate selections compared with control cells. When combined with hydroxyurea or aphidicolin and compared with the effects of either dru

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Rollins, M. B., and M. T. Andrews. "Morphogenesis and regulated gene activity are independent of DNA replication in Xenopus embryos." Development 112, no. 2 (1991): 559–69. http://dx.doi.org/10.1242/dev.112.2.559.

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Xenopus embryos were transferred into media containing aphidicolin at late blastula, mid-gastrula, and early neurula stages. In each case, embryos continued to differentiate in the absence of DNA replication. When the inhibitor was added at late blastula, embryos continued to develop for about 8 h. However, when aphidicolin was added at the early neurula stage, development could be seen for up to 40 h after addition. The influence of replication on embryonic gene activity was studied by RNA blot analysis. Of the genes we examined only histone gene expression was down regulated by the addition

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Dissertations / Theses on the topic "Aphidicolin"

1

Gordon, J. "The biosynthesis of aphidicolin." Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375170.

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Kennedy, Robert M. "A total synthesis of aphidicolin." Diss., Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/54307.

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A formal total synthesis of aphidicolin, an important antitumor agent, has been accomplished. Completion of this synthesis required the development of novel methodology. Virtually all of the previous syntheses of aphidicolin share a common difficulty in the construction of the C-9 and C-10 vicinal quaternary centers. In order to solve this problem an investigation into the Michael reaction was launched. This study has revealed that steric encumbrance may be overcome by electronic activation of the acceptor. In fact, two withdrawing substituents were found to make possible the addition of the

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3

Allen, Lewis Alexander Thomas. "Studies on the total synthesis of aphidicolin." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/58237.

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In this thesis further developments on the thermal cascade reaction discovered in the Parsons group have been made. The substrate scope has been increased to include the ketone linked 1,6-diynes, which had failed to cyclise in previous studies. Furthermore, variations on the precursor molecule have led to the cyclisation of nitrogen and sulphur analogues to provide the respective annulated pyrrole and thiophene products. The synthesis of these compounds using the Parsons-Board-Waters cyclisation had not been explored during earlier studies within the group. The increased scope of the Parsons-B

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Boynton, Juliette Alice. "The synthesis of biologically active steroids." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239715.

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Hegarty, Philip. "A novel approach to the skeleta of both the aphidicolin and stemodin diterpenoids." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239849.

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6

Santos, Gabriela Bianchi dos. "Semi-síntese de derivados da afidicolina: busca por novos protótipos leishmanicidas." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-27092012-104700/.

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O presente trabalho aborda a transformação semi-sintética de afidicolina visando a criação de uma biblioteca de compostos para fins de ensaios de atividade sobre espécies de Leishmania spp. Recentemente, estudos demonstraram a alta atividade da afidicolina, um diterpeno tetracíclico produzido pelo fungo Nigrospora sphaerica, frente ao protozoário Leishmania major. Apesar do promissor potencial leishmanicida, a afidicolina apresenta propriedades físico-químicas e perfil farmacocinético inadequado para terapêutica. Considerando que abordagens semi-síntética são comuns na busca de novos protótipo

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Shyam, Sunitha. "S-phase Synchronization Promotes Chemoradiotherapy-induced Apoptosis in Prostate Cancer Cell Lines." Kent State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=kent1185835523.

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Suzuki, Susumu, Motoshi Suzuki, and Shonen Yoshida. "Characterization of the human DNA polymerase of catalyticsubunit expressed by a recombinant baculovirus." Nagoya University School of Medicine, 2000. http://hdl.handle.net/2237/5358.

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9

Almeida, Marília Oliveira de. "Obtenção de derivados dos terpenos enidrina e afidicolina por biotransformação e semi-síntese e avaliação da atividade leishmanicida." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-10052010-132553/.

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Biotransformações são reações de compostos orgânicos realizadas por microrganismos, plantas ou enzimas isoladas. A transformação de um composto em particular pode ser realizada em grupos funcionais com ou sem degradação de seu esqueleto. Neste trabalho foram utilizados fungos endofíticos e de solo na biotransformação da lactona sesquiterpênica enidrina e do diterpeno afidicolina. A enidrina possui atividade antidiabética e anti-inflamatória. A afidicolina possui pronunciada atividade antitumoral, antiviral e leishmanicida. Foram realizados experimentos de biotransformação da enidrina e da afid

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10

Mello, Rodrigo Brito de. "Produção de biblioteca de compostos derivados de produtos naturais: síntese e estudo de atividades biológicas." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-17042015-151409/.

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O presente trabalho trata da semissíntese de análogos de importantes compostos líderes (afidicolina, lausona, lapachol e CAPE) utilizando técnicas de química medicinal como bioisosterismo, adição de grupamento funcional e simplificação molecular. Dessa forma foi possível obter uma biblioteca de análogos racionais, visando a manipulação de parâmetros físico-químicos e estruturais, para fins de bioprospecção. Foram desenvolvidos derivados de afidicolina mais lipofílicos, por meio da acilação das hidroxilas presentes na estrutura química deste terpeno. Tentativas de formação de bioisósteros, sais

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Book chapters on the topic "Aphidicolin"

1

Ghiron, Chiara, and Russell J. Thomas. "Synthese von (±)-Aphidicolin." In Teubner Studienbücher Chemie. Vieweg+Teubner Verlag, 1994. http://dx.doi.org/10.1007/978-3-322-80121-0_60.

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2

Sargent, J. M., A. W. Elgie, C. J. Williamson, and C. G. Taylor. "Aphidicolin Markedly Increases the In Vitro Sensitivity to ARA-C of Blast Cells From Patients with AML." In Drug Resistance in Leukemia and Lymphoma III. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4811-9_62.

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3

Schomburg, Dietmar, and Ida Schomburg. "aphidicolan-16β-ol synthase 4.2.3.42." In Class 3.4–6 Hydrolases, Lyases, Isomerases, Ligases. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36260-6_63.

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4

"Aphidicolin." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_1018.

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"Aphidicolin." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_352.

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6

Sala, Francesco, Maria Grazia Galli, Guido Pedrali-Noy, and Silvio Spadari. "Synchronization of plant cells in culture and in meristems by aphidicolin." In Methods in Enzymology. Elsevier, 1986. http://dx.doi.org/10.1016/0076-6879(86)18066-9.

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7

COLE, RICHARD J., BRUCE B. JARVIS, and MILBRA A. SCHWEIKERT. "Aphidicolins." In Handbook of Secondary Fungal Metabolites. Elsevier, 2003. http://dx.doi.org/10.1016/b978-012179460-6/50333-3.

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8

Aizawa, Shin-Ichi. "Buchnera aphidicola — Flagella Not for Motility." In The Flagellar World. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-417234-0.00031-1.

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9

"Comparative genomics in Buchnera aphidicola, primary endosymbiont of aphids." In Insect Symbiosis, Volume 2. CRC Press, 2006. http://dx.doi.org/10.1201/9781420005936-13.

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10

Moya, Andrés, and Amparo Latorre. "Comparative genomics in Buchnera aphidicola, primary endosymbiont of aphids." In Insect Symbiosis, Volume 2. CRC Press, 2006. http://dx.doi.org/10.1201/9781420005936.ch9.

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