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Journal articles on the topic 'Apigenin-7-O-glucoside'

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Published: 5 June 2025
Last updated: 2 August 2025

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1

Mishio, Tamaki, Kosaku Takeda, and Tsukasa Iwashina. "Anthocyanins and Other Flavonoids as Flower Pigments from Eleven Centaurea Species." Natural Product Communications 10, no. 3 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000318.

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Anthocyanins and other flavonoids were isolated from the flowers of eleven Centaurea species, C. macrocephala, C. rupestotilis and C. suaveolens, which produce yellow flowers, and C. achtarovii, C. dealbata, C. montana, C. nigra, C. scabiosa, C. simplicicaulis, C. hypoleuca and C. triumfetti, which have cyanic flowers. Four anthocyanins, cyanidin 3,5-di- O-glucoside, cyanidin 3- O-(6″-malonylglucoside)-5- O-glucoside, cyanidin 3- O-(6″-succinylglucoside)-5- O-glucoside and cyanidin glycoside, were detected in the cyanic flowers of seven Centaurea species. Of these anthocyanins, the first two w
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2

Wang, Yuxiao, Zhenzhen Xu, Yuqi Huang, et al. "Extraction, Purification, and Hydrolysis Behavior of Apigenin-7-O-Glucoside from Chrysanthemum Morifolium Tea." Molecules 23, no. 11 (2018): 2933. http://dx.doi.org/10.3390/molecules23112933.

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Apigenin-7-O-glucoside is an active phenolic compound in Asteraceae flowers and possesses remarkable therapeutic applications. However, its high price and low abundance in plants limit its use, meanwhile it would hydrolyze in the purification process. In this study, apigenin-7-O-glucoside extracted with ultrasound and purified with preparative HPLC from Chrysanthemum morifolium ‘Huangju’ was investigated, as well as its hydrolysis behavior and bioactivities. The optimized extraction conditions were: solid/liquid ratio: 1:20, extraction time: 35 min, temperature: 50 °C, and ultrasound power: 35
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3

El-Desouky, Samy K., Lamyaa F. Ibrahim, Salwa A. Kawashty, et al. "Phytochemical Constituents and Biological Activities of Origanum syriacum." Zeitschrift für Naturforschung B 64, no. 4 (2009): 447–51. http://dx.doi.org/10.1515/znb-2009-0416.

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The cytotoxicity of the methanol extract of Origanum syriacum against human cerivical adenocarcinoma, Hela cells, was evaluated by the MTT assay. From the crude extract, a new flavone glycoside, acacetin-7-O-[2´´-O-α-L-rhamnopyranosyl-6´´-O-β -D-glucopyranosyl]-β -D-glucopyranoside (1), together with the ten known flavonoids luteolin (2), apigenin (3), luteolin-6-C-glucoside (4), luteolin-3´-methylether-6-C-glucoside (5), luteolin-7,4´-dimethyether-6-C-glucoside (6), apigenin-7- methylether-6-C-glucoside (7), apigenin-7-O-glucoside (8), diosmetin-7-O-glucoside (9), acacetin- 7-O-glucoside (10)
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4

Sezen Karaoğlan, Esen, Hayrunisa Hancı, Mehmet Koca, and Cavit Kazaz. "Some Bioactivities of Isolated Apigenin-7-O-glucoside and Luteolin-7-O-glucoside." Applied Sciences 13, no. 3 (2023): 1503. http://dx.doi.org/10.3390/app13031503.

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In this study, we aimed to isolate compounds from Stachys lavandulifolia (Lamiaceae) by chromatographic methods and perform tyrosinase, acetylcholinesterase, butyrylcholinesterase enzyme-inhibition and antimicrobial activity studies of these compounds by in vitro methods. In addition, a molecular docking study was planned for the molecule with the highest effect. Two flavone glycosides, apigenin-7-O-glucoside and luteolin-7-O-glucoside, were isolated from S. lavandulifolia. Both compounds were observed to be effective against Enterococcus faecalis, Klebsiella pneumoniae, and Staphylococcus aur
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5

Ilic, Sanja, Sanja Djakovic, Jelena Cvejic, Mirjana Antov та Zoran Zekovic. "Bioconversion of apigenin-7-O-β-glucoside in aqueous two-phase system". Acta Periodica Technologica, № 36 (2005): 197–202. http://dx.doi.org/10.2298/apt0536197i.

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The study is concerned with the conversion of apigenin-7-O-?-glucoside into apigenin in polyethylene glycol 6000 / dextran 20000 aqueous two-phase system by ?-glucosidase. Apigenin was separated from apigenin-7-O-?-glucoside and ?-glucosidase by their partition into opposite phases. In 14% PEG / 22.5% DEX aqueous two-phase system obtained yield of apigenin in top phase was 108%.
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6

Kusano, Katsumi, Tsukasa Iwashina, Junichi Kitajima, and Tamaki Mishio. "Flavonoid Diversity of Saussurea and Serratula Species in Tien Shan Mountains." Natural Product Communications 2, no. 11 (2007): 1934578X0700201. http://dx.doi.org/10.1177/1934578x0700201115.

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Nine Saussurea species, S. alberti, S. elegans, S. gnaphalodes, S. involucrata, S. konuroba, S. kuschakewiczii, S. leucophylla, S. schanginiana and S. sordida, and Serratula lyratifolia from the Tien Shan Mountains and adjacent area were chemically characterized for flavonoids. Thirty-one flavonoids and one hydroquinone were isolated from the leaves of these species and identified from mass spectrometric, UV, 1H and 13C NMR spectroscopic data, by characterization of hydrolyzates, and direct TLC and HPLC comparisons with authentic samples as kaempferol 3-O-rutinoside (1), quercetin 3-O-rutinosi
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7

Uehara, Ayumi, and Tsukasa Iwashina. "Flavonoids from the Japanese Monotypic Genus, Nipponanthemum." Natural Product Communications 7, no. 8 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700811.

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Foliar flavonoids of Nipponanthemum, which is a monotypic genus and consists of only one Japanese endemic species, N. nipponicum, were isolated for the first time. Fifteen flavonoids, i.e. six glycosides, quercetin 3,7-di- O-glucoside, vicenin-2, quercetin 3- O-glucoside, luteolin 7- O-glucoside, kaempferol 3- O-glucoside and apigenin 7- O-glucoside, and nine aglycones, luteolin, nepetin, quercetin 3-methyl ether, axillarin, apigenin, hispidulin, chrysoeriol, jaceosidin and sudachitin were identified. Of these compounds, the flavonoid aglycones existed on the leaf surface.
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8

Blázquez, María Amparo, Salvador Máñez, and María Carmen Zafra-Polo. "Further Flavonoids and Other Phenolics of Thymus webbianus Rouy." Zeitschrift für Naturforschung C 49, no. 9-10 (1994): 687–88. http://dx.doi.org/10.1515/znc-1994-9-1021.

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Abstract Seven different flavonoids from the aerial parts of Thymus webbianus were isolated. They were identified by UV spectra, TLC and HPLC-DAD as luteolin, api­genin, eryodictiol, naringenin, luteolin-7-O-glucoside, apigenin-7-O-glucoside and apigenin-6,8-di-C-glucoside. Other phenolics characterized by HPLC-DAD analysis were: protocatechuic, chlorogenic, syringic, p-coumaric and 3,5-dicaffeoylquinic acids.
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9

Lal, Uma Ranjan, Shailendra Mani Tripathi, Sanjay M. Jachak, Kamlesh Kumar Bhutani, and Inder Pal Singh. "RP-HPLC Analysis of Jirakadyarishta and Chemical Changes during Fermentation." Natural Product Communications 5, no. 11 (2010): 1934578X1000501. http://dx.doi.org/10.1177/1934578x1000501113.

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Jirakadyarishta, an Ayurvedic formulation prepared by the fermentation of a decoction of Cuminum cyminum (seeds) is traditionally used for intestinal disorders. RP-HPLC analysis of the decoction and the final processed formulation revealed that apigenin-7- O-[galacturonide (1→4)- O-glucoside] and luteolin-4′- O-glucoside-7- O-galacturonide) were the two major constituents of the decoction of C. cyminum. Selective hydrolysis of 7 -O-glucosides of luteolin and apigenin during fermentation resulted in an increase in the amount of luteolin and apigenin. The 4′- O-glucoside-7- O-galacturonide of lu
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10

Shanaida, Mariia, Olesia Palamar, and Olena Holembiovska. "Chromatographic Profile of Polyphenols in the Agastache foeniculum (Pursh) Kuntze Herb: Evaluation of Optimal Extraction Efficiency." Biomedical and Pharmacology Journal 17, no. 1 (2024): 63–69. http://dx.doi.org/10.13005/bpj/2834.

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During its triple extraction, the HPLC analysis revealed polyphenols' contents in the A. foeniculum herb. Several hydroxycinnamic acids (rosmarinic, chlorogenic, ferulic and caffeic) and flavonoids (apigenin, apigenin-7-O-glucoside, hyperoside, quercitrin, rutin and quercetin) were identified in the A. foeniculum herb. It was established that rosmarinic acid followed by apigenin-7-O-glucoside and apigenin were the predominant compounds of the A. foeniculum raw material. The content of rosmarinic acid as the major compound during the primary, secondary and tertiary extraction decreased in the f
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11

CICEK, MAHMUT, NERIMAN AYDILEK, SEYMA ULUSOY, et al. "Cytotoxic Activity and Evaluation of In Vitro Release of Apigenin 7-O-Glucoside From the Topical Pharmaceutical Formulation Containing Matricaria recutita L. Flower Extract." Acta Poloniae Pharmaceutica - Drug Research 81, no. 3 (2024): 483–501. http://dx.doi.org/10.32383/appdr/192338.

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The extracts from flower heads of Matricaria recutita L. have various biological effects, most notably anti-inflammatory. The most important flavonoid is apigenin, which is mostly found in the form of apigenin-7-O-glucoside. Apigenin-7-O-glucoside is assessed as a marker in Matricaria recutita L. extracts due to its anti-inflammatory effect. In this study, a new, cost-effective, and accurate HPLC-PDA method was developed and implemented for the quantification of apigenin-7-O-glucoside in liquid extracts of the flowers of Matricaria recutita L. grown in Türkiye (Bandırma/Balıkesir) and Türkiye
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12

Hussain, Farieha, Nazish Jahan, Khalil-ur Rahman, Bushra Sultana, and Saba Jamil. "Identification of Hypotensive Biofunctional Compounds ofCoriandrum sativumand Evaluation of Their Angiotensin-Converting Enzyme (ACE) Inhibition Potential." Oxidative Medicine and Cellular Longevity 2018 (November 15, 2018): 1–11. http://dx.doi.org/10.1155/2018/4643736.

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The aim of this study was to identify and characterize the bioactive compounds ofCoriandrum sativumresponsible for the treatment of hypertension and to explore their mechanism of action as angiotensin-converting enzyme (ACE) inhibitors. Bioactive fractions like alkaloids, flavonoids, steroids, and tannins were extracted and evaluated for their ACE inhibition potential. Among them, only flavonoid-rich fraction showed high ACE inhibition potential with IC50value of 28.91 ± 13.42 μg/mL. The flavonoids were characterized through LC-ESI-MS/MS. Seventeen flavonoids were identified in this fraction o
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13

MITSOPOULOS, Georgios, Vasiliki PAPAGEORGIOU, Michael KOMAITIS, and Marianna HAGIDIMITRIOU. "Phenolic Profile of Leaves and Drupes of Ten Olive Varieties." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 44, no. 1 (2016): 162–66. http://dx.doi.org/10.15835/nbha44110382.

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Leaves and drupes of the olive varieties "Koroneiki", "Lianolia Kerkyras", "Mastoidis", "Arbequina", "Adramytini", "Megaritiki", "Gaidourelia", "Kalamata", "Konservolia" and "Chalkidiki" were collected at different seasons during 2008 and 2009 and investigated by HPLC for their phenolic profile and the concentration of the phenolic compounds present. The phenolic compounds identified in 2008 new season leaves were, in declining concentration order, oleuropein, 7-O-glucoside of luteolin and rutin whereas for those collected in 2009 the main phenolic compounds were oleuropein, rutin, 4-O-glucosi
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14

Rashed, Khaled. "IN-VITRO ANTIVIRAL ACTIVITY OF PISTACIA CHINENSIS FLAVONOIDS AGAINST HEPATITIS C VIRUS (HCV)." Journal of Applied Pharmacy 6 (2014): 8. http://dx.doi.org/10.21065/19204159.6.8.

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The present study was designed to evaluate anti-HCV activity of Pistacia chinensis aerial parts and identify the responsible bioactive constituents of anti-hepatitis ethnomedicinal plant P. chinensis methanol 80% extract. This has led to the isolation and characterization of gallic acid and eight flavonoids, apigenin, diosmetin, myricetin, apigenin 7-O-β-glucoside, quercetin 3-O-β-glucoside myricetin 3-O-α-rhamnoside, myricetin 3-O-β-glucuronide and quercetin 3-O-β-glucoside-7-O-α-rhamnoside from the plant, using various chromatographic procedures and the interpretation of spectral data
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15

Jockovic, Nebojsa, Paula Andrade, Patrícia Valentão, and Marko Sabovljevic. "HPLC-DAD of phenolics in bryophytes Lunularia cruciata, Brachytheciastrum velutinum and Kindbergia praelonga." Journal of the Serbian Chemical Society 73, no. 12 (2008): 1161–67. http://dx.doi.org/10.2298/jsc0812161j.

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The chemistry of bryophytes is not well known. The available data indicate interesting chemical constitutions of some bryophyte species, i.e., active and new compounds are to be found within bryophytes, especially liverworts. In this study, one liverwort and two moss species were studied: Lunularia cruciata (L.) Dumort, Brachytheciastrum velutinum (Hedw) Ignatov & Huttunen and Kindbergia praelonga (Hedw) Ochyra. The phenolic compositions of these bryophyte species have not hitherto been reported. Their methanolic extracts were analyzed by reversed-phase HPLC, coupled to a diode-array detec
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16

Tiss, Mohamed, and Khaled Hamden. "Globularia alypum Extracts Attenuate Hyperglycemia and Protect against Various Organ Toxicities in Alloxan-Induced Experimental Diabetic Rats." Evidence-Based Complementary and Alternative Medicine 2022 (August 30, 2022): 1–13. http://dx.doi.org/10.1155/2022/6816942.

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In this study, we attempted for the first time to determine the phytochemical compositions and biopharmaceutical properties of Globularia alypum methanol extract (GAME) and Globularia alypum water extract (GAWE). High-performance liquid chromatography with diode array detection (HPLC-DAD) analysis was performed to establish the chemical profile of the investigated extracts. Chemical composition analysis was taken in the presence of various bioactive compounds such as quercetin 7-O-glucoside and apigenin 7-O-glucoside in GAME. In GAWE, various abundant compounds were found in the extract such a
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17

Karlová, K. "Accumulation of flavonoid compounds in flowering shoots of Achillea collina Becker ex. Rchb. Alba during flower development." Horticultural Science 33, No. 4 (2011): 158–62. http://dx.doi.org/10.17221/3756-hortsci.

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 The objective of this paper was a screening of flavonoid content in Achillea collina Becker ex. Rchb. Alba flowering tops (Herba millefolii) and flowers (Flos millefolii). Ten developmental stages of plant (flowers and tops separately) – from the beginning of flower differentiation to ripe seed stage – were studied. The methanol extract of plant material was used for HPLC analysis. The flavones apigenin, luteolin, and their 7-O-glucosides were found as the main flavonoid constituents in all developmental stages of both flower and top drug. Apigenin and apigenin-7-
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18

Ahmed, Fahem A., and Abdelaaty A. Shahat. "Flavonoid C-Glycosides from Pterocephalus Sanctus Growing in Egypt." Natural Product Communications 1, no. 6 (2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100605.

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Two flavonoid C-glycosides, isolated from Pterocephalus sanctus (Dipsaceae), were identified as luteolin-6-C-β-D-glucoside-7-O-methyl ether and apigenin-6-C-β-D-glucoside-7-O-methyl ether on the basis of spectroscopic studies.
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19

Zhao, Lin, Yuqiong Pei, Guoxin Zhang, et al. "Efficient Synthesis and In Vitro Hypoglycemic Activity of Rare Apigenin Glycosylation Derivatives." Molecules 28, no. 2 (2023): 533. http://dx.doi.org/10.3390/molecules28020533.

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Apigenin is a natural flavonoid with significant biological activity, but poor solubility in water and low bioavailability limits its use in the food and pharmaceutical industries. In this paper, apigenin-7-O-β-(6″-O)-d-glucoside (AG) and apigenin-7-O-β-(6″-O-succinyl)-d-glucoside (SAG), rare apigenin glycosyl and succinyl derivatives formed by the organic solvent-tolerant bacteria Bacillus licheniformis WNJ02 were used in a 10.0% DMSO (v/v) system. The water solubility of SAG was 174 times that of apigenin, which solved the application problem. In the biotransformation reaction, the conversio
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20

Sheychenko, Olga Petrovna, Vladimir Ivanovich Sheychenko, Sergey Vladimirovich Goryainov, et al. "CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF THE DRY EXTRACT "ROSMATIN" FROM THE HERB OF DRACOCEPHALUM MOLDAVICA L." chemistry of plant raw material, no. 3 (September 27, 2021): 253–64. http://dx.doi.org/10.14258/jcprm.2021039161.

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Moldavian Dragonhead (Dracocephalum moldavica L.) is an annual herb. In FGBNU VILAR a new variety of Moldavian Dragonhead «Nezhnost» has been developed. From the herb of the Moldavian Dragonhead, a technology has been developed for obtaining a dry purified extract, which has received the code name «Rozmatin».
 By NMR (1H and 13C) and HPLC-DAD-MS using standard samples and literature data, the qualitative and quantitative composition of the dry extract "Rozmatin" from the herb of the Dracocephalum moldavica was established. Rosmarinic, caffeic and ferulic acids, rosmarinic acid 3-O-glucosi
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21

Asnaashari, S., A. Delazar, Seyed Alipour, et al. "Chemical composition, free-radical-scavenging and insecticidal activities of the aerial parts of Stachys byzantina." Archives of Biological Sciences 62, no. 3 (2010): 653–62. http://dx.doi.org/10.2298/abs1003653a.

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Stachys byzantina K. Koch. is an Iranian endemic species of the genus Stachys L., which comprises about 300 species, and is one of the largest genera of the family Lamiaceae. A combination of solid phase extraction (SPE) and high pressure liquid chromatography (HPLC) of the methanolic extract of the aerial parts of S. byzantina afforded three phenylethanoids, 2'-O-arabinosyl verbascoside (1), verbascoside (2), aeschynanthoside C (3) and three flavones apigenin 7-O-glucoside (4), apigenin 7-O-(6-p-coumaroyl)-glucoside (5) and apigenin (6). The structures of these compounds were determined by sp
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22

Salama, Maha M., Shahira M. Ezzat, and Amany A. Sleem. "A New Hepatoprotective Flavone Glycoside from the Flowers of Onopordum alexandrinum Growing in Egypt." Zeitschrift für Naturforschung C 66, no. 5-6 (2011): 251–59. http://dx.doi.org/10.1515/znc-2011-5-608.

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A bioactivity-guided fractionation of the ethyl acetate fraction of the flowers of Onopordum alexandrinum L. (Asteraceae) yielded a new flavonoidal glycoside designated as acacetin-7-O-galacturonide (9), alongside with nine known flavonoids; 6-methoxy-apigenin (hispidulin) (1), acacetin (2), apigenin (3), luteolin (4), kaempferol (5), eriodictyol (6), apigenin- 7-O-glucoside (7), luteolin-7-O-glucoside (8), and kaempferol-3-O-rutinoside (10). The compounds were assayed for their hepatoprotective activity against CCl4-induced hepatic cell damage in rats and free radical scavenging activity usin
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23

Chaves, Douglas S. A., Flávia S. Frattani, Mariane Assafim, Ana Paula de Almeida, Russolina B. Zingali, and Sônia S. Costa. "Phenolic Chemical Composition of Petroselinum Crispum Extract and Its Effect on Haemostasis." Natural Product Communications 6, no. 7 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600709.

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From the aqueous extract (Pc) of Petroselinum crispum (Mill) flat leaves specimens were isolated and identified the flavonoids apigenin (1), apigenin-7- O-glucoside or cosmosiin (2), apigenin-7- O-apiosyl-(1→2)- O-glucoside or apiin (3) and the coumarin 2″,3″-dihydroxy-furanocoumarin or oxypeucedanin hydrate (4). The inhibitory activity toward clotting formation and platelet aggregation was assessed for Pc flavonoids (1) and (2), and the coumarin (4). Pc showed no inhibition on clotting activity when compared with the control. On the other hand, a strong antiplatelet aggregation activity was o
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24

Jo, Beom-Geun, Sim-Kyu Bong, Jonghwan Jegal, Su-Nam Kim, and Min Hye Yang. "Antiallergic Effects of Phenolic Compounds Isolated From Stellera chamaejasme on RBL-2H3 Cells." Natural Product Communications 15, no. 7 (2020): 1934578X2094235. http://dx.doi.org/10.1177/1934578x20942352.

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The current study was undertaken to isolate and identify anti-inflammatory and antiallergic active compounds in the ethyl acetate and butanol fractions of an ethanolic extract of the aerial parts of Stellera chamaejasme (SCAE). A new maltol glucoside, maltol 3-(6″-(2-( E)-butenoyl)-glucoside) and benzoic acid, daphnoretin (a coumarin), 6 flavonoids (apigenin, genkwanin, taxifolin, apigenin 7- O-glucoside, luteolin 7- O-sambubioside, genkwanin 5- O-glucoside), and 2 lignans (matairesinoside and lariciresinol) were isolated from SCAE by chromatographic separation. Their chemical structures were
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25

Singh, U. P., V. B. Pandey, K. N. Singh, and R. D. N. Singh. "Antifungal activity of some new fiavones and fiavone glycosides of Echinops echinatus." Canadian Journal of Botany 66, no. 9 (1988): 1901–3. http://dx.doi.org/10.1139/b88-260.

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Four phenolic compounds, viz., apigenin, apigenin-7-O-glucoside, echinacin, and echinaticin, were isolated from the whole plant of Echinops echinatus Roxb.; the latter two compounds were isolated for the first time. The two derivatives echinacin permethyl ether and apigenin-5,4′-dimethyl ether were obtained by methylation of echinacin and apigenin-7-O-glucoside permethylate, respectively. All the compounds were assayed against germination of conidia of Alternaria tenuissima (Kunz. ex Pers.) Wiltshire, which incites leaf blight disease in pigeon pea (Cajanus cajan (L.) Millsp.). All showed high
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Stefanakis, Michalis K., Olga St Tsiftsoglou, Pavle Z. Mašković, Diamanto Lazari, and Haralambos E. Katerinopoulos. "Chemical Constituents and Anticancer Activities of the Extracts from Phlomis × commixta Rech. f. (P. cretica × P. lanata)." International Journal of Molecular Sciences 25, no. 2 (2024): 816. http://dx.doi.org/10.3390/ijms25020816.

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The present work is the first report on the ingredients of the P. × commixta hybrid, a plant of the genus Phlomis. So far, thirty substances have been isolated by various chromatographic techniques and identified by spectroscopic methods, such as UV/Vis, NMR, GC-MS and LC-MS. The compounds are classified as flavonoids: naringenin, eriodyctiol, eriodyctiol-7-O-β-D-glucoside, luteolin, luteolin-7-O-β-D-glucoside, apigenin, apigenin-7-O-β-D-glucoside, diosmetin-7-O-β-D-glucoside, quercetin, hesperetin and quercetin-3-O-β-D-glucoside; phenylpropanoids: martynoside, verbascoside, forsythoside B, ec
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27

Xie, Xiao-Yu, Fang-Fang Chen, and Yan-Ping Shi. "Simultaneous Determination of Eight Flavonoids in the Flowers of Matricaria chamomilla by High Performance Liquid Chromatography." Journal of AOAC INTERNATIONAL 97, no. 3 (2014): 778–83. http://dx.doi.org/10.5740/jaoacint.13-029.

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Abstract An HPLC method was developed for simultaneous determination of five flavones (apigenin, three apigenin 7-O-glucoside acylated derivatives, and luteolin) and three methoxylated flavonols in Matricaria chamomilla. Full validation of the assay was carried out including linearity, LODs, LOQs, precision, repeatability, stability, and accuracy. The results demonstrated that the method developed was simple, accurate, and reliable. Five batches of M. chamomilla samples were determined using the developed method, and total contents of the eight flavonoids ranged from 1.843 to 2.134 mg/g. Among
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28

Hwang, Seung Hwan, Zhiqiang Wang, Yanymee N. Guillen Quispe, Soon Sung Lim, and Jae Myung Yu. "Evaluation of Aldose Reductase, Protein Glycation, and Antioxidant Inhibitory Activities of Bioactive Flavonoids in Matricaria recutita L. and Their Structure-Activity Relationship." Journal of Diabetes Research 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/3276162.

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The inhibitory activities of Matricaria recutita L. 70% methanol extract were evaluated by isolating and testing 10 of its compounds on rat lens aldose reductase (RLAR), advanced glycation end products (AGEs), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging. Among these compounds, apigenin-7-O-β-D-glucoside, luteolin-7-O-β-D-glucoside, apigenin-7-O-β-D-glucuronide, luteolin-7-O-β-D-glucuronide, 3,5-O-di-caffeoylquinic acid, apigenin, and luteolin showed potent inhibition, and their IC50 values in RLAR were 4.25, 1.12, 1.16, 0.85, 0.72, 1.72, and 1.42 μM, respectively. Furthermore,
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Bolzon, Lucas B., Joicy S. dos Santos, Denise B. Silva, et al. "Apigenin-7-O-glucoside oxidation catalyzed by P450-bioinspired systems." Journal of Inorganic Biochemistry 170 (May 2017): 117–24. http://dx.doi.org/10.1016/j.jinorgbio.2017.02.016.

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30

Terencio, Mari Carmen, María Jesús Sanz, María Luisa Fonseca, Salvador Máñez, and José Luis Ríos. "Phenolic Compounds from Lactuca viminea L." Zeitschrift für Naturforschung C 47, no. 1-2 (1992): 17–20. http://dx.doi.org/10.1515/znc-1992-1-204.

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Abstract The aerial part of Lactuca viminea L. was examined for the presence of phenolic compounds. Six different flavonoids were isolated and identified by UV spectra, TLC, HPLCDAD , 1H NMR and 13C NMR. They were identified as apigenin, luteolin, quercetin, luteolin-7-O-glucoside, quercetin-3-O-glucoside and luteolin-7-O-glucuronide-6″methyl ester. Three phenolic acids were also detected: caffeic, ferulic and chlorogenic acid.
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31

Gan, Xiaona, Bo Peng, Liang Chen, et al. "Identification of Xanthine Oxidase Inhibitors from Celery Seeds Using Affinity Ultrafiltration–Liquid Chromatography–Mass Spectrometry." Molecules 28, no. 16 (2023): 6048. http://dx.doi.org/10.3390/molecules28166048.

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Celery seeds have been used as an effective dietary supplement to manage hyperuricemia and diminish gout recurrence. Xanthine oxidase (XOD), the critical enzyme responsible for uric acid production, represents the most promising target for anti-hyperuricemia in clinical practice. In this study, we aimed to establish a method based on affinity ultrafiltration–liquid chromatography–mass spectrometry (UF–LC–MS) to directly and rapidly identify the bioactive compounds contributing to the XOD-inhibitory effects of celery seed crude extracts. Chemical profiling of celery seed extracts was performed
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32

Stanojevic, Ljiljana, Mihajlo Stankovic, Ljubisa Nikolic, and Vesna Nikolic. "The influence of the operation conditions and the extraction techniques on the yield, kinetics and the composition of ethanol extracts of Hieracium pilosella L." Chemical Industry and Chemical Engineering Quarterly 13, no. 4 (2007): 199–204. http://dx.doi.org/10.2298/ciceq0704199s.

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The optimal operational extraction conditions (50 % v/v ethanol, solvomodule l:15 m/v, temperature: the solvent boiling temperature) were determined by investigating the influence of the ethanol concentration (30 - 95 % v/v), solvomodule (1:10 - 1:25 m/v) and the temperature of the maceration extraction on the yield and kinetics of total extraction matter, chlorogenic acid, umbelliferone and apigenin-7-O-glucoside from Hieracium pilosella L. Based on the results of Soxhlet and Tillepape extraction kinetics, the investigations of the total extraction matter and the components under the optimal
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Weyepe Lah, Fidèle Castro, Marius Balemaken Missi, Natasha October, et al. "Antibacterial and Antioxidant Activities of the Extract and Some Flavonoids From Aerial Parts of Echinops Gracilis O. Hoffm. (Asteraceae)." Natural Product Communications 16, no. 3 (2021): 1934578X2199915. http://dx.doi.org/10.1177/1934578x21999151.

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Mortality due to microbial diseases continues to be a major problem in many developing countries. The present study aims to evaluate the antibacterial and antioxidant activities of the ethyl acetate extract and some isolated compounds from aerial parts of Echinops gracilis. The phytochemical study resulted in the isolation of a new flavonoid derivative named apigenin-7- O-(4″-feruloyl)-β-D-glucoside (1), together with 2 known compounds: apigenin -7-O-(4″-trans- p-hydroxycinnamoyl) -β-D-glucoside (2), and apigenin -7-O-glucoside (3). Their chemical structures were determined using a combination
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Istifli, Erman Salih. "Chemical Composition, Antioxidant and Enzyme Inhibitory Activities of Onosma bourgaei and Onosma trachytricha and in Silico Molecular Docking Analysis of Dominant Compounds." Molecules 26, no. 10 (2021): 2981. http://dx.doi.org/10.3390/molecules26102981.

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The aim of this study was to investigate the chemical composition, antioxidant and enzyme inhibitory activities of methanol (MeOH) extracts from Onosma bourgaei (Boiss.) and O. trachytricha (Boiss.). In addition, the interactions between phytochemicals found in extracts in high amounts and the target enzymes in question were revealed at the molecular scale by performing in silico molecular docking simulations. While the total amount of flavonoid compounds was higher in O. bourgaei, O. trachytricha was richer in phenolics. Chromatographic analysis showed that the major compounds of the extracts
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Uehara, Ayumi, Junichi Kitajima, Goro Kokubugata, and Tsukasa Iwashina. "Further Characterization of Foliar Flavonoids in Crossostephium chinense and their Geographic Variation." Natural Product Communications 9, no. 2 (2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900207.

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Foliar flavonoids of Crossostephium chinense in Japan and Taiwan were isolated and further characterized. Eighteen flavonoid aglycones, luteolin, apigenin, hispidulin, chrysoeriol, 5,7,4′-trihydroxy-6,3′,5′-trimethoxyflavone, jaceosidin, cilsimaritin, quercetin 3-methyl ether, axillarin, chrysosplenol-D, cirsiliol, apometzgerin, 5,7,3′-trihydroxy-6,4′,5′-trimethoxyflavone, luteolin 3′,4′-dimethyl ether, cirsilineol, eupatilin, nepetin and 5,7,3′,4′-tetrahydroxy-6,5′-dimethoxyflavone, were identified by UV, 1H and 13C NMR spectroscopic, LC-MS and HPLC comparisons with authentic samples. The com
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36

Voronov, Ivan Vasil'yevich, Nadezhda Sofronovna Danilova, and Varvara Vasil'yevna Semenovа. "THE CONTENT OF RUTIN, APIGENIN-7-O-GLUCOSIDE AND THE LEVEL OF PHOTOSYNTHETIC PIGMENTS OF ALYSSUM LENENSE ADAMS (BRASSICACEAE BURNETT) GROWING IN DIFFERENT PHYTOCENOTIC CONDI-TIONS OF CENTRAL YAKUTIA." chemistry of plant raw material, no. 1 (March 16, 2021): 129–37. http://dx.doi.org/10.14258/jcprm.2021018770.

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The features of accumulation of rutin and apigenin-7-O-glucoside and their distribution in the aboveground organs of Alyssum lenense Adams (Brassicaceae Burnett) were revealed. The content of photosynthetic pigments was investigated depending on the phytocenotic conditions of plant growth in the territory of Central Yakutia. The data obtained on the content of flavonoids are characterized by an uneven distribution over organs with respect to different phytocenotic conditions of the growth of cenopopulations. A. lenense was collected during flowering period in 8 cenopopulations and in the colle
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37

Imperato, Filippo. "A New Flavone Glucoside, Apigenin 7-O-glucoside 4′-acetate and a New Fern Constituent, Quercetin 3-O-rhamnoside-7-O-glucoside fromDryopteris villarii." American Fern Journal 98, no. 4 (2008): 251–53. http://dx.doi.org/10.1640/0002-8444-98.4.251.

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Jiménez-Moreno, Cimminelli, Volpe, et al. "Phenolic Composition of Artichoke Waste and its Antioxidant Capacity on Differentiated Caco-2 Cells." Nutrients 11, no. 8 (2019): 1723. http://dx.doi.org/10.3390/nu11081723.

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Artichoke waste represents a huge amount of discarded material. This study presents the by-products (bracts, exterior leaves, and stalks) of the “Blanca de Tudela” artichoke variety as a potential source of phenolic compounds with promising antioxidant properties. Artichoke residues were subjected to different extraction processes, and the antioxidant capacity and phenolic composition of the extracts were analyzed by spectrophotometric methods and high performance liquid chromatography (HPLC) analyses, respectively. The most abundant polyphenols in artichoke waste were chlorogenic acid, luteol
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Iwashina, Tsukasa, Goro Kokubugata, Koh Nakamura, et al. "Flavonoids from three Wild Glycine Species in Japan and Taiwan." Natural Product Communications 13, no. 12 (2018): 1934578X1801301. http://dx.doi.org/10.1177/1934578x1801301218.

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Fourteen flavonols, four flavones and six isoflavones were isolated from the aerial parts of two Japanese Glycine species, G. tabacina and G. koidzumii, and the leaves of Taiwanese G. max subsp. formosana. Of their flavonoids, twelve flavonols were identified as kaempferol 3- O-sophoroside (1), 3- O-rutinoside (2), 3- O-robinobioside (3) and 3- O-rhamnosyl-(1→4)-[rhamnosyl-(1→6)-galactoside] (4), quercetin 3- O-gentiobioside (5), 3- O-glucoside (6), 3- O-galactoside (7), 3- O-rutinoside (8), 3- O-robinobioside (9) and 3- O-rhamnosyl-(1→4)-[rhamnosyl-(1→6)-galactoside] (10), and isorhamnetin 3-
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40

Dai, Tran Duc, Dao Duc Thien, and Nguyen Thanh Tam. "Flavone glycosides from Uraria crinita." Ministry of Science and Technology, Vietnam 63, no. 2 (2021): 3–6. http://dx.doi.org/10.31276/vjste.63(2).03-06.

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Four flavone glycosides including apigenin 7-O-β-glucoside (1), chrysoeriol 7-O-β-glucoside (2), rhoifolin (3), and 3′-methoxyapiin(4) were isolated from the n-butanol extract of the whole plant Uraria crinita collected in the phu Tho province, Vietnam. Their structures were elucidated by 1D- and 2D-NMR spectra and compared with those reported in the literature. Compounds 1-3 were obtained from the genus Uraria for the first time.
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Yamamoto, Hirobumi, Masahiko Ichimura, Noriko Ishikawa, Toshiyuki Tanaka, Munekazu Iinuma, and Mizuo Mizuno. "Localization of Prenylated Flavonoids in Sophora flavescens var. angustifolia Plants." Zeitschrift für Naturforschung C 47, no. 7-8 (1992): 535–39. http://dx.doi.org/10.1515/znc-1992-7-808.

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A histochemical analysis was carried out on the distribution of flavonoid derivatives in Sophora flavescens var. angustifolia plant. Prenylated flavonoids such as kushenol I, kurarinone, sophoraflavanone G and des-O-methylanhydroicaritin were mainly localized in the periderm (cork layers, and cork layer-like tissues scattered in parenchymatous tissues of the root system). Pterocarpan derivatives, maackiain, maackiain-3-O-glucoside (trifolirhizin) and its 6′-O-malonyl ester, were distributed in the cortex, cambium and pith as an ester form. In the aerial parts of the plant, neither pterocarpan
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Petreska, Jasmina, Gjose Stefkov, Svetlana Kulevanova, Kalina Alipieva, Vassya Bankova, and Marina Stefova. "Phenolic Compounds of Mountain Tea from the Balkans: LC/DAD/ESI/MSn Profile and Content." Natural Product Communications 6, no. 1 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600107.

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Twenty-one samples of Sideritis species ( S. scardica, S. raeseri, S. taurica, S. syriaca and S. perfoliata) from various locations on the Balkan Peninsula were evaluated for their chemical constituents. Chemical analyses were focused on secondary metabolites, particularly phenolic compounds, which have several roles in the plant physiological processes and have demonstrated significant health beneficial effects. The occurrence of hydroxycinnamic acids, phenylethanoid glycosides and flavonoids has been investigated in taxonomically related taxa of the genus Sideritis. A systematic method for p
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Kamel, Emadeldin M., Sarah I. Othman, Hassan A. Rudayni, Ahmed A. Allam, and Al Mokhtar Lamsabhi. "Multi-pronged molecular insights into flavonoid-mediated inhibition of squalene epoxidase: a pathway to novel therapeutics." RSC Advances 15, no. 5 (2025): 3829–48. https://doi.org/10.1039/d4ra09076d.

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Apigenin-7-O-glucoside, silibinin, and baicalin are potent squalene epoxidase inhibitors with promising therapeutic potential. Integrative in silico and experimental studies pave the way for hypercholesterolemia and antifungal therapies.
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Valcic, Susanne, Gerald A. Wächter, Gloria Montenegro, and Barbara N. Timmermann. "Triterpenoids from Acaena pinnatifida R. et P." Zeitschrift für Naturforschung C 52, no. 3-4 (1997): 264–66. http://dx.doi.org/10.1515/znc-1997-3-420.

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Abstract Eight urs-12-ene triterpenoids, β-sitosterol, (+)-catechin, and apigenin 7-O-glucoside were isolated from the leaves of Acaena pinnatifida R. et P. The triterpenoids were characterized as pomolic acid, pomolic acid-3-acetate, tormentic acid, 2-epi-tormentic acid, euscaphic acid, tormentic acid glucoside, niga-ichigoside F1, and niga-ichigoside F2.
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Uehara, Ayumi, Shinobu Akiyama, and Tsukasa Iwashina. "Foliar Flavonoids from Tanacetum vulgare var. boreale and their Geographical Variation." Natural Product Communications 10, no. 3 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000307.

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Foliar flavonoids of Tanacetum vulgare var. boreale were isolated. Eight flavonoid glycosides, 7- O-glucosides of apigenin, luteolin, scutellarein and 6-hydroxyluteolin, and 7- O-glucuronides of apigenin, luteolin, chrysoeriol and eriodictyol were identified. Moreover, eight flavonoid aglycones, apigenin, luteolin, hispidulin, nepetin, eupatilin, jaceosidin, pectolinarigenin and axillarin were also isolated and identified. The flavonoid composition of two varieties of T. vulgare, i.e. var. boreale and var. vulgare, were compared. All samples of var. boreale and one sample of var. vulgare had t
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46

Linh, Nguyen Thi Thuy, Ba Thi Cham, Nguyen Thi Hoang Anh, et al. "Flavonoid from the aerial parts of Cardiospermum halicacabum L." Vietnam Journal of Chemistry 61, no. 1 (2023): 80–83. http://dx.doi.org/10.1002/vjch.202200033.

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AbstractThe first chemical investigation on Cardiospermum halicacabum L. growing in Vietnam led to the isolation and structural determination of nine flavonoid compounds, including quercetin 3‐O‐β‐D‐glucoside (1), quercetin 3‐O‐α‐L‐rhamnoside (2), quercetin (3), kaempferol 3‐O‐α‐L‐rhamnoside (4), kaempferol (5), apigenin 7‐O‐β‐D‐glucuronide butyl ester (6), apigenin 7‐O‐β‐D‐glucuronide methyl ester (7), apigenin (8), and luteolin (9). Their structures were established by using HR ESI MS, 1D and 2D NMR spectroscopic methods and comparison with those of the related published data. With exception
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47

Djakovic, Sanja, Sanja Ilic, Jelena Cvejic, Milica Atanackovic, Mirjana Antov, and Zoran Zekovic. "Camomile autofermentation in polyethylene glycol/dextran two-phase system." Acta Periodica Technologica, no. 39 (2008): 133–38. http://dx.doi.org/10.2298/apt0839133d.

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The objective of this study was the investigation of the extractive bioconversion of apigenin-7-O-?-glucoside in camomile ligulate flowers into apigenin by autofermentation in polyethylene glycol 6000/dextran 200000 two-phase system. In 22.5% polyethylene glycol/14% dextran aqueous two-phase system the obtained yield of apigenin in the top phase was 96.5%. In the presence of plant material that partiotioned to the interphase, the yield of apigenin in the top phase was 3.5 times higher in comparison to the model system.
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48

Minda, Daliana, Stefana Avram, Ioana Zinuca Pavel, et al. "An in vitro Evaluation of Apigenin and Apigenin-7-O-glucoside Against HeLa Human Cervical Cancer Cell Line." Revista de Chimie 71, no. 2 (2020): 140–44. http://dx.doi.org/10.37358/rc.20.2.7906.

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pigenin (API) is a phytocompound belonging to the subclass of flavones that can be found in both functional foods as well as medicinal plants. Recent studies have assigned API antioxidant, anti-inflammatory, anti-spasmodic, anti-viral, anti-thrombotic, anti-angiogenic and chemopreventive potential in vitro on various cell lines and/or in experimental animal models. Apigenin-7-O-glucoside (API-7) is one of its main glycosides and can be commonly found in chamomile flowers, parsley, celery. The aim of this study was to evaluate the in vitro anti-proliferative and pro-apoptotic effects of API and
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49

Xiong, Lewen, Wenjing Huang, Yan Liu, et al. "Study on Antipyretic Properties of Phenolics in Lonicerae Japonicae Flos Based on Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry Combined with Network Pharmacology." Journal of Food Biochemistry 2023 (December 8, 2023): 1–17. http://dx.doi.org/10.1155/2023/8883860.

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Objective. To identify and quantify the active phenolic components in Lonicerae japonicae flos (LJF) for fever treatment and their mechanism of action using network pharmacology and molecular docking. Methods. Based on qualitative analysis of LJF, 194 phenolics were obtained, including 81 phenolic acids and 113 flavonoids. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were used to identify potential targets for these components to interact with fever. Molecular docking with microsomal PGE2 synthase-1, EP1, EP2, EP3, and EP4 targets was used to determine antipyretic
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Stanojevic, Ljiljana, Mihajlo Stankovic, Milorad Cakic, Vesna Nikolic, Ljubisa Nikolic, and Dusica Ristic. "The effect of the operation conditions and the extraction techniques on the yield, kinetics and composition of methanol extracts of Hieracium pilosella L." Chemical Industry 63, no. 2 (2009): 79–86. http://dx.doi.org/10.2298/hemind0902079s.

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The optimal operational extraction conditions were determined by investigating the influence of the methanol concentration, solvomodule and temperature of the maceration extraction on the yield and kinetics of total extractive matter, chlorogenic acid, umbelliferone and apigenin-7-O-glucoside from Hieracium pilosella L. Based on the results of Soxhlet and Tillepape extraction kinetics investigations of the total extractive matter and the components under the optimal maceration operation conditions it was found that the highest yields of the extractive matter and investigated bioactive componen
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