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Dissertations / Theses on the topic 'ApoE-/- mouse'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Reverté, Soler Ingrid. "Neurobehavioural effects associated with postnatal exposure to decabromodiphenyl ether in apoe2, apoe3 and apoe4 transgenic mice." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/76782.

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El Decabromodifenil èter (BDE-209) és un retardant de la flama àmpliament utilitzat i font de preocupació a causa de la toxicitat mostrada per altres Difenil Èters Polibromats (PBDEs). La presència de PBDEs en la llet materna fa preocupant la seva exposició durant el desenvolupament. Pensem que l’exposició primerenca a BDE-209 pot produir efectes a llarg termini i interactuar amb factors genètics, com el genotip de l’ApolipoproteinaE. Ratolins portadors de les diferents isoformeshumanes de l’ApoE foren tractats amb una dosi oral aguda de 0, 10 o 30 mg / kg de BDE-209 en el dia postnatal 10 i

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2

Martinic, Goran (Gary), of Western Sydney Hawkesbury University, of Science Technology and Environment College, and School of Environment and Agriculture. "Cyclodextrins as potential human anti-atherosclerotic agents." THESIS_CSTE_EAG_Martinic_G.xml, 2001. http://handle.uws.edu.au:8081/1959.7/129.

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Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides. Since it is believed that OxC blocks the removal of normal cholesterol from cells in the artery wall, it is possible that selective removal of OxC in the vessel wall in-vivo may prevent or reverse atherosclerosis.As a prelude to major studies, this research project was designed to answer two critical questions; 1/. What is the best route for delivery of CD. 2/. How do animals (apoE-/- mice) tolerate it. Pilot studies were established and results noted. These studies have provided valuable information in the apoE-/- mouse for

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3

Haskett, Darren. "Progressive Alterations in Microstructural Organization and Biomechanical Response in the ApoE Mouse Model of Aneurysm and the Underlying Changes in Biochemistry." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/581126.

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Abdominal Aortic Aneurysm (AAA) is a complex disease that leads to a localized dilation of the infrarenal aorta that develops over years. Longitudinal information in humans has been difficult to obtain for this disease, therefore mouse models have become increasingly used to study the development of AAAs. The objective of this study was to determine any changes that occur in the biomechanical response and fiber microstructure in the apolipoprotein E difficient (ApoE-/-) angiotensin II (AngII) infused mouse model of aneurysm during disease progression, as well as determine some of the underlyin

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4

Harris, Julian David. "Development of recombinant adeno-associated virus and second generation adenovirus vectors for the gene transfer of human apolipoprotein E (ApoE) in the APOE deficient mouse." Thesis, Royal Holloway, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420867.

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5

Armour, Danielle Louise. "Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis : studies in the Apoe-/- /11β-HSD2-/- double knockout mouse". Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4431.

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It is well established that atherosclerosis, an inflammatory response to chronic injury in the blood vessel wall, plays a leading role in the development and progression of cardiovascular disease. Mineralocorticoid receptor (MR) over-activation has been implicated in atherosclerosis. In mineralocorticoid-target tissues, 11β- Hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates glucocorticoids, conferring aldosterone specificity upon the normally unselective MR. Recent evidence suggests that 11β-HSD2 may also afford protection of MR in the cells of the vasculature, providing possible mech

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6

Martinic, Gary. "Cyclodextrins as potential human anti-atherosclerotic agents." Thesis, View thesis View thesis, 2001. http://handle.uws.edu.au:8081/1959.7/129.

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Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides. Since it is believed that OxC blocks the removal of normal cholesterol from cells in the artery wall, it is possible that selective removal of OxC in the vessel wall in-vivo may prevent or reverse atherosclerosis.As a prelude to major studies, this research project was designed to answer two critical questions; 1/. What is the best route for delivery of CD. 2/. How do animals (apoE-/- mice) tolerate it. Pilot studies were established and results noted. These studies have provided valuable information in the apoE-/- mouse for

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7

Ampem, Prince Tuffour. "The Transient Receptor Potential Canonical 3 (TRPC3) Channel: Novel Role in Endothelial Cell Apoptosis and its Impact on Atherosclerosis." University of Toledo Health Science Campus / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=mco1493230041479167.

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8

Nakouzi, Ghunwa Akram. "Genetic and Phenotypic Response of Neural Tube Defect Mouse Mutants to Folic Acid." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1246538783.

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9

Hoffman, Jared D. "THE PREBIOTIC INULIN BENEFICIALLY MODULATES THE GUT-BRAIN AXIS BY ENHANCING METABOLISM IN AN APOE4 MOUSE MODEL." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacol_etds/24.

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Alzheimer’s disease (AD) is the most common form of dementia and a growing disease burden that has seen pharmacological interventions primarily fail. Instead, it has been suggested that preventative measures such as a healthy diet may be the best way in preventing AD. Prebiotics are one such potential measure and are fermented into metabolites by the gut microbiota and acting as gut-brain axis components, beneficially impact the brain. However, the impact of prebiotics in AD prevention is unknown. Here we show that the prebiotic inulin increased multiple gut-brain axis components such as scyll

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10

Schröck, Evelin, P. Zschieschang, Peter O’Brien, et al. "Spectral karyotyping of human, mouse, rat and ape chromosomes – applications for genetic diagnostics and research." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-137653.

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Spectral karyotyping (SKY) is a widely used methodology to identify genetic aberrations. Multicolor fluorescence in situ hybridization using chromosome painting probes in individual colors for all metaphase chromosomes at once is combined with a unique spectral measurement and analysis system to automatically classify normal and aberrant chromosomes. Based on countless studies and investigations in many laboratories worldwide, numerous new chromosome translocations and other aberrations have been identified in clinical and tumor cytogenetics. Thus, gene identification studies have been facilit

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11

Schröck, Evelin, P. Zschieschang, Peter O’Brien, et al. "Spectral karyotyping of human, mouse, rat and ape chromosomes – applications for genetic diagnostics and research." Karger, 2006. https://tud.qucosa.de/id/qucosa%3A27746.

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Spectral karyotyping (SKY) is a widely used methodology to identify genetic aberrations. Multicolor fluorescence in situ hybridization using chromosome painting probes in individual colors for all metaphase chromosomes at once is combined with a unique spectral measurement and analysis system to automatically classify normal and aberrant chromosomes. Based on countless studies and investigations in many laboratories worldwide, numerous new chromosome translocations and other aberrations have been identified in clinical and tumor cytogenetics. Thus, gene identification studies have been facilit

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12

Casimiro, Renata Inês Proença. "Coupling of atherosclerosis progression and bone disturbances in a mouse model." Master's thesis, 2015. http://hdl.handle.net/10451/20859.

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Tese de mestrado em Biologia Humana e Ambiente, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2015<br>As doenças que afectam o sistema cardiovascular e o osso estão entre as doenças que causam maior morbilidade e mortalidade na população, em especial a aterosclerose e a osteoporose. Vários estudos epidemiológicos têm demonstrado que estas duas doenças podem estar relacionadas de alguma forma, uma vez que ambas as patologias estão normalmente presentes no mesmo doente. Doentes com patologia cardiovascular apresentam um risco 1.2 a 6.7 vezes maior de sofrer de fraturas

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13

Moheimani, Fatemeh. "Effect of a polyunsaturated fatty acid mimetic on the development of atherosclerosis in the apoE deficient mouse." Thesis, 2005. http://hdl.handle.net/2440/59454.

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Atheroma, heart attacks and strokes continue to be a major cause of morbidity and mortality in our community. Atherosclerosis is a chronic inflammatory vascular disease, characterised by thickening of the vascular wall due to lipid accumulation, infiltration by circulating monocytes and T cells and proliferation of smooth muscle cells. Leukocyte adherence to the blood vessel wall is promoted by the up-regulation of cell adhesion molecules (CAM) by atherogenic substances such as tumour necrosis factor (TNF-α) and oxidised low density lipoprotein (oxidised-LDL). Recently our group has synthe

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14

Moheimani, Fatemeh. "Effect of a polyunsaturated fatty acid mimetic on the development of atherosclerosis in the apoE deficient mouse." 2005. http://hdl.handle.net/2440/59454.

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Atheroma, heart attacks and strokes continue to be a major cause of morbidity and mortality in our community. Atherosclerosis is a chronic inflammatory vascular disease, characterised by thickening of the vascular wall due to lipid accumulation, infiltration by circulating monocytes and T cells and proliferation of smooth muscle cells. Leukocyte adherence to the blood vessel wall is promoted by the up-regulation of cell adhesion molecules (CAM) by atherogenic substances such as tumour necrosis factor (TNF-α) and oxidised low density lipoprotein (oxidised-LDL). Recently our group has synthe

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15

Ormonde, Beatriz Maria Lemos. "Antiatherogenic Properties from Oleacein Extracted from Olive Tree and Olive Oil - Experimental Study in Animal Model." Master's thesis, 2021. http://hdl.handle.net/10316/98287.

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Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e Tecnologia<br>A aterosclerose é o principal substrato para a maioria das doenças cardiovasculares (DCVs), que são a maior causa de mortalidade a nível mundial. Os fatores de risco para o desenvolvimento de aterosclerose e de outras DCVs, além dos não modificáveis, relacionam-se com estilos de vida pouco saudáveis, incluindo dietas hipercalóricas e hiperlipídicas, bem como sedentarismo. Estes fatores estão associados a outras doenças, tais como obesidade e esteatose hepática. Abordagens não farmacológicas, nomeadamente

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16

Ormonde, Beatriz Maria Lemos. "Antiatherogenic Properties from Oleacein Extracted from Olive Tree and Olive Oil - Experimental Study in Animal Model." Master's thesis, 2021. http://hdl.handle.net/10316/98479.

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Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e Tecnologia<br>A aterosclerose é o principal substrato para a maioria das doenças cardiovasculares (DCVs), que são a maior causa de mortalidade a nível mundial. Os fatores de risco para o desenvolvimento de aterosclerose e de outras DCVs, além dos não modificáveis, relacionam-se com estilos de vida pouco saudáveis, incluindo dietas hipercalóricas e hiperlipídicas, bem como sedentarismo. Estes fatores estão associados a outras doenças, tais como obesidade e esteatose hepática. Abordagens não farmacológicas, nomeadamente

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17

Saul, Anika. "Pathophysiological Characterization of intra‐ and extracellularly aggregated Amyloid Peptides in Dementias." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-0022-6379-C.

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18

Agarwal, Umesh. "Characterization of a non-invasive hyperspectral microscopic imaging system for monitoring the vascular development of diabetic retinopathy in the Double-Knock-Out apoE-/- db/db Mouse Model." 2009. http://hdl.handle.net/10106/2082.

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19

Mleczko, Anna. "A novel pathway for VLDL assembly in the mouse liver." Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-AC3B-1.

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20

Lee, Jung-Hsuan, and 李容瑄. "Morse Theory to Reeb''s Theorem and its Generalization." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/38936612442251708008.

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碩士<br>淡江大學<br>數學學系碩士班<br>101<br>In this thesis, we want to use Morse Theorem to prove Reeb''s Theorem. Before showing the proof of these theorems, we need to review some basic properties of a differentiable manifold M with a differentiable structure. In general, if we define some functions from M (or its subspace) to real value, the difference between manifold and coordinate space should be considered. Every point we choose must send to a coordinate subspace first. So defining a coordinate system is helpful to deal with any functions on manifold M. The main result we review is to p

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21

Chung, Cheng-Chun, and 鍾政君. "The Study of the Effects of Source Credibility of Word-of-Mouse, Consumers'' Trust and Involvement on Purchase Intention." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/38078009421171013269.

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碩士<br>朝陽科技大學<br>應用外語研究所<br>99<br>With the high development of internet technology, it appears more and more consumer product discussions in the internet. Consumers tend to read consumer’s review online before they buying an unfamiliar product for helping decision making. Word-of-mouse has the characteristics of lasting longer time, no geographic restriction, and anonymity. However, anonymity of Internet occurs the doubt of the credibility of word-of-mouse. The purpose of this study is to explore the relationships among source credibility of word-of-mouse, consumers’ trust, involvement and purc

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