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Dissertations / Theses on the topic 'Apoptosis - Theses'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Yu, J. "The measurement of apoptosis in HIV-1 infection." Thesis, Link to the online version, 2006. http://hdl.handle.net/10019/1325.

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2

Davis, Tanja. "A characterisation of genes involved in apoptosis resistance." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/80335.

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Thesis (MSc)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Apoptosis represents a finely orchestrated and highly conserved natural form of cell death. It exhibits unique morphological and biochemical characteristics which culminate in the controlled dismantling of a cell from within followed by its discreet removal by phagocytic cells. Apoptosis is vital for the preservation of cell and tissue homeostasis but also performs several defensive and protective functions. Owing to its importance, apoptosis is highly regulated and a large number of proteins have been shown to mediate and safeg

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3

Cote, Shelly A. "Effects of Cellular Apoptosis on Productivity of a Mammalian Cell Culture Process." Digital WPI, 2006. https://digitalcommons.wpi.edu/etd-theses/192.

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Apoptosis, programmed cell death, is a hot topic in recent research due to the potential applications to various areas by regulating its pathway. In industrial large scale animal cell culture processes, research on how to regulate or predict the apoptotic pathway and understanding what signals the apoptotic cascade has lead to a new opportunity to enhance process robustness, improve final performance including productivity, and eventually, reduce production costs. Current industrial cell culture processes normally involve a high cell density process in a large-scale bioreactor as a suspensi

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4

Liu, June. "Role of macrophage apoptosis in atherosclerosis." [Johnson City, Tenn. : East Tennessee State University], 2004. http://etd-submit.etsu.edu/etd/theses/available/etd-1109104-011324/unrestricted/LiuJ111804f.pdf.

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Thesis (Ph.D.)--East Tennessee State University, 2004.<br>Title from electronic submission form. ETSU ETD database URN: etd-1109104-011324 Includes bibliographical references. Also available via Internet at the UMI web site.

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5

Kessler, Josiah Elihu. "A STUDY OF OSTEOCYTE APOPTOSIS IN MECHANICALLY LOADED AND UNLOADED MURINE TIBIAE." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1550.

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Previous research has provided evidence in support of apoptotic osteocytes playing a role in the bone remodeling process. In this study, we examined the regional and quadrantal variations of apoptotic and viable osteocytes in cyclically loaded and unloaded samples. Left tibias of C57 Black 6 Taconic mice (C57Bl/6) were cyclically loaded for either 2 weeks or 5 weeks, with the right tibias being used as controls. After loading, tibias were resected, processed, and then stained using either a TUNEL stain, to show apoptotic osteocytes, or a 2.0% methyl green solution, to reveal viable cells. Cros

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6

Siravuri, Krishi. "Quantification of Chondrocyte Apoptosis in Mechanically Impacted Articular Cartilage." NCSU, 2007. http://www.lib.ncsu.edu/theses/available/etd-05102007-092520/.

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Osteoarthritis is a severely debilitating joint disorder. It is slowly progressing chronic disease and has no precise known causes. Impact injury can lead to cellular and matrix changes in articular cartilage similar to those seen in osteoarthritis. Impact injury models are often used as models for osteoarthritis. The purpose of this study was to use an in vitro impact injury model to examine the distribution and timing of apoptosis cell death following an impact injury. In this study it was hypothesized that there will be an increase in apoptosis cells with increasing impact load; that over t

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7

Cowling, Rebecca. "Structure-function Analysis of NRAGE: A Protein Involved in Developmental Neural Apoptosis." Fogler Library, University of Maine, 2006. http://www.library.umaine.edu/theses/pdf/CowlingRA2006.pdf.

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8

Chan, Jessica Kristen. "A STUDY OF OSTEOCYTE APOPTOSIS BY REGION AND QUADRANT IN MURINE CORTICAL BONE." DigitalCommons@CalPoly, 2011. https://digitalcommons.calpoly.edu/theses/455.

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ABSTRACT A Study of Osteocyte Apoptosis by Region and Quadrant in Murine Cortical Bone Jessica Kristen Chan Osteocytes undergo apoptosis to spatially and temporally initiate bone remodeling. This study investigates the distribution of apoptotic osteocytes within different quadrants and regions of cortical bone and compares the frequency of osteocyte apoptosis to regional factors associated with bone remodeling. Specifically, the quantity of apoptosis was compared to levels of the bone morphagenic protein antagonists noggin and gremlin. Samples of unloaded right tibial bone obtained from C57

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9

Ronayne, Rachel E. "Human Ependymin-1 Neurotrophic Factor Mimetics Reduce Tau Phosphorylation and Cellular Apoptosis in Vitro and in Vivo in Alzheimerâ€™s Disease Models." Digital WPI, 2008. https://digitalcommons.wpi.edu/etd-theses/1018.

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"Alzheimerâ€™s disease (AD) is the most widespread neurodegenerative disorder, affecting approximately 20 million people worldwide. AD pathology is primarily characterized by the formation of extracellular amyloid plaques resulting from the aggregation of insoluble amyloid-beta 1-42 (A-beta), and neurofibrillary tangles (NFTâ€™s) resulting from intracellular aggregation of hyperphosphorylated tau protein. The current FDA-approved AD treatments do not stop or reverse neurodegeneration, but only treat the symptoms by increasing acetylcholine neurotransmitter. Our laboratory is attempting to p

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10

Harvey, Natasha. "The biochemical and cellular analysis of caspase-2 activation during apoptosis." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phh3415.pdf.

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Errata sheet has been pasted onto reverse of back end paper. Bibliography: leaves 116-145. Apoptosis, or programmed cell death, is a fundamental process during both embryonic development and adult homeostasis. Aberrant apoptosis has been associated with a number of human diseases, which may arise either from a failure of cells to undergo apoptosis, or from excessive apoptosis. Understanding of the cellular components of the apoptotic machinery should contribute to the design of therapeutic agents which may be beneficial in the treatment of diseases which have disruptions in the apoptotic path

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11

Garg, Himanshu. "Feline Immunodeficiency Virus (FIV) Envelope Glycoprotein-Mediated Cell Fusion and Apoptosis." NCSU, 2003. http://www.lib.ncsu.edu/theses/available/etd-11042003-141554/.

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Feline Immunodeficiency Virus (FIV) and Human Immunodeficiency Virus (HIV) are lentiviruses that are remarkable similar in their genomic organization, receptor usage and pathogenesis. Based on this FIV has evolved into a well-established small animal model for studying AIDS. FIV and HIV cause a progressive depletion of T cells via a still unknown mechanism though numerous studies support a role of membrane expressed HIV env glycoprotein in apoptotic killing of CD4+ T cells. HIV env glycoprotein is a heterodimer of surface expressed gp120 that binds to CD4 and a chemokine receptor and transmemb

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12

Skinner, Rebecca. "Irinotecan induces apoptosis with changes in pro-apoptotic Bcl-2 family protein expression in jejunal and colonic crypts of rodents with breast cancer /." Title page and abstract only, 2003. http://web4.library.adelaide.edu.au/theses/09SB/09sbs6286.pdf.

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13

Dorstyn, Loretta Esterina. "The identification and characterisation of two novel Drosophila caspases, DRONC and DECAY." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phd718.pdf.

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Includes a list of publications co-authored by the author during the preparation of this thesis. Thesis amendments in back leaf. Includes bibliographical references (leaves 123-168). The studies described concentrate on the cloning and characterisation of the two Drosophila caspases, DRONC and DECAY

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14

Hodge, Sandra Joy. "The role of apoptosis in the pathogenesis of chronic obstructive pulmonary disease." Title page, table of contents and synopsis only, 2003. http://web4.library.adelaide.edu.au/theses/09PH/09phh6885.pdf.

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"April 2003" Bibliography: leaves 268-290. In chronic obstructive pulmonary disease (COPD) there is inadequate repair of the chronically damaged and inflamed airway epithelium. There is a school of thought that this inadequate repair may result from an accumulation of apoptotic material in the airways, resulting in secondary necrosis, tissue destruction and chronic inflammation. This thesis is an investigation of apoptosis and clearance of apoptotic cells on COPD using samples of peripheral blood, and bronchial brushings and bronchial lavage obtained from the airways during fibreoptic bronchos

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15

Bouralexis, Stelios. "Molecular mechanisms of Apo2L/TRAIL induced apoptosis in normal and malignant cells /." Title page, contents and synopsis only, 2003. http://web4.library.adelaide.edu.au/theses/09PH/09phb766.pdf.

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16

Butler, Lisa Maree. "Molecular analysis of the human Fas gene in colorectal cancer /." Title page, contents and summary only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phb9858.pdf.

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17

Santos, Michelle Hanthequeste Bittencourt dos. "Papel de metaloproteases de Estreptococos do grupo B na interação,viabilidade celular e indução de apoptose e necrose em células endoteliais e epiteliais humanas." Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9169.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Estreptococos do grupo B (EGB) é a principal causa de sepse e meningite neonatal e tem sido recentemente reconhecido como patógeno responsável por infecções invasivas em adultos imunocomprometidos (idosos ou portadores de doenças crônicas). Os EGB produzem inúmeras enzimas extracelulares, várias das quais interagem com o sistema imune do hospedeiro e são importantes durante a interação EGB-hospedeiro, bem como para o desenvolvimento da doença. Estudos anteriores mostraram que metaloproteases estão envolvidas em várias vias metabó

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18

Chai, Fugui. "Mechanisms of apoptosis of colorectal cancer cells by butyrate and other preventive agents." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phc4337.pdf.

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Bibliography: leaves 168-201. The main aims of this study were firstly, to study the mechanism by which butyrate (the main fermentation product of dietary fibre) induces apoptosis of CRC cells, and secondly, to determine the effect of butyrate in combination with NSAIDs (chemopreventive agents) and other agents on apoptosis of CRC cells. For these studies LIM1215 cells and, in some experiments, SW480 cells were used. The experiments described in this thesis provided new data on the caspase-3 activation and apoptosis in butyrate-induced apoptosis of CRC cells, and the interaction of these proce

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19

Crott, Jimmy. "Effect of vitamin C supplements on chromosome damage, apoptosis and necrosis ex vivo /." Title page and introduction only, 1997. http://web4.library.adelaide.edu.au/theses/09S.B/09s.bc9516.pdf.

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Thesis (B. Sc.(Hons.))--University of Adelaide, Dept. of Physiology, 1997.<br>Spine title: Effect of vitamin C on chromosome damage, apoptosis and necrosis. Includes bibliographical references (leaves 30-34).

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20

Draper, David William. "The Role of Calcium and Phosphorylation in the Activation of cPLA2 During TNF-induced Apoptosis." NCSU, 2004. http://www.lib.ncsu.edu/theses/available/etd-04102004-174824/.

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Tumor necrosis factor (TNF) is a pleotropic cytokine that mediates many inflammatory and innate immune responses. TNF also causes apoptosis in certain transformed cell lines and cells that are infected with certain viruses or intracellular bacteria. Cytosolic phospholipase A2 (cPLA2) is an inflammatory enzyme that mediates its activities, by specifically catalyzing the release of arachidonic acid leading to the generation of eicosanoids. The activity of cPLA2 is necessary during TNF-induced apoptosis and the goal of this study was to identify signals that mediate the activation of cPLA2 during

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21

Tran, Cuong-Duy. "The effects on apoptosis of butyrate and sulindac sulphide in HL60 and LIM 1215 cells /." Title page and abstracts only, 1994. http://web4.library.adelaide.edu.au/theses/09SB/09sbt772.pdf.

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22

Hantak, Alison Marie. "Ginsenosides enhance the cytotoxicity of tumor necrosis factor-α in human MDA-MB 231 and MCF-7 breast cancer cells in a caspase-dependent manner". OpenSIUC, 2009. https://opensiuc.lib.siu.edu/theses/123.

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Ginsenosides (GF) are a major bioactive constituent of ginseng and have been shown to elicit a multitude of actions ranging from the improvement of synaptic plasticity to the improved uptake of glucose into a cell. Furthermore, ginsenosides and their metabolites have been shown to be potent anti-cancer agents in multiple experimental cancer models. The aim of this study was to investigate the potential influence of GF derived from American ginseng root (Panax quinquefolius), and a ginsenoside metabolite Rh2, on tumor necrosis factor-α (TNF-α) cytotoxicity in MDA-MB 231 and MCF-7 human breast

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23

Alexander, Michael Stephen. "A COMPUTATIONAL MODEL OF APOPTOTIC OSTEOCYTE CORRELATION TO CORTICAL BONE REMODELING PARAMETERS." DigitalCommons@CalPoly, 2009. https://digitalcommons.calpoly.edu/theses/205.

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The onset of osteoporosis caused by aging, disease states, and post-menopausal conditions significantly impacts patient quality of life, required healthcare funding, personal autonomy losses from increased fracture risk and the subsequent corrective surgery. Research has indicated that osteocyte apoptosis may be a key parameter in bone remodeling, raising the possibility of remodeling rate modulation for the mitigation of bone mass resorption. By developing therapies that target osteocyte apoptosis, it may be possible to prevent undesired bone remodeling activity while maintaining a healthy b

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24

Strom, Chrisitna Nelson. "Salinity Regulation of Prolactin Cell Proliferation and Apoptosis in the Euryhaline Teleost, the Tilapia (Oreochromis mossambicus)." NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-08062008-095001/.

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The euryhaline tilapia, Oreochromis mossambicus, has the ability to live in both freshwater (FW) and saltwater (SW) environments. Prolactin (PRL) is the most critical hormone to promoting life in FW, and without it tilapia loses the capacity to osmoregulate in hypotonic environments. Consistent with PRLâs actions in FW adaptation, pituitary PRL synthesis, content, secretion, and cell activity are all elevated in FW compared to SW acclimated tilapia We found that the PRL region of a FW tilapia pituitary has a 3-fold larger volume than the PRL region of a SW pituitary. It is unclear whether this

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25

Smith, Joshua. "Investigating the Apoptotic Effects of Platinum(II) Amine Complexes With Only One Leaving Ligand on Zebrafish Auditory End Organs." TopSCHOLAR®, 2018. https://digitalcommons.wku.edu/theses/2340.

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The FDA-approved platinum compound, cisplatin, is commonly used as a chemotherapy drug to treat many forms of cancer. However, this compound also has several associated side-effects, including ototoxicity. This has made the development of novel platinum compounds that reduce cancer cell viability, while causing fewer and milder side-effects, an area of significant research interest. In the present study, we examined the apoptotic effects that four monofunctional platinum compounds, pyriplatin, phenanthriplatin, Pt(diethylenetriamine)Cl, and Pt(N,Ndiethyldiethylenetriamine) Cl, had on zebrafish

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26

Bennett, Ailsa. "Exploiting mitosis to improve anti-cancer strategies." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/exploiting-mitosis-to-improve-anticancer-strategies(b29182a1-2f37-47cb-8dc5-cbef76786dd2).html.

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Antimitotics are used in cancer chemotherapy for the treatment of cancers such as breast, ovarian, lung and prostate. Despite the success of agents such as Taxol, problems have emerged such as side effects, resistance and the lack of ability to predict patient responsiveness. As a result, a class of second-generation inhibitors have been developed with the aim to overcome or improve these issues. Such inhibitors target proteins and kinases involved in the control of mitosis and the cell cycle. However, these have yet to be clinically successful and therefore, this highlights the requirement fo

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27

Loots, Stanley. "Erythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection : relationship with immune activation and viraemia." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85803.

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Thesis (MScMedSc)-- Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Chronic HIV-1 infection is characterized by extensive inflammation/immune activation and also by anaemia. Macrophages and neutrophils produce reactive oxygen species (ROS) which can cause damage to surrounding cells, including erythrocytes. Damaged erythrocytes may die by apoptosis (erythroptosis) or be tagged for clearance by monocytes/ macrophages. In this study we investigated HIV-1-associated anaemia and erythroptosis in asymptomatic, untreated HIV-1 infected individuals and how it relates to oxidative stress and immun

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28

kapoor, varun. "Mechanism of Reversal of Alzheimerâ€™s Disease A-beta Induced Neuronal Degeneration in Cultured Human SHSY Cells Using A Neurotrophic Ependymin Mimetic." Digital WPI, 2007. https://digitalcommons.wpi.edu/etd-theses/908.

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"Alzheimerâ€™s disease (AD) is a neurodegenerative disorder that leads to dementia in adults. The mechanism of neurodegeneration is thought to involve the extracellular production of a highly toxic A-beta peptide that engages cell surface receptors to induce cellular oxidative stress and apoptosis, but the signal transduction pathways that lead to A-beta induced cell death are unknown. We previously showed that a human ependymin neurotrophic peptide mimetic (hEPN-1) can promote cell survival in an in vitro AD model system. This initial observation was extended in this thesis by investigatin

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29

Fedor, Elizabeth Ann. "Caffeine Supplementation and Moderate Intensity Exercise Modulates the Cytotoxic Lymphocyte Subset (CD+8) in NaIve and Tolerant Individuals." TopSCHOLAR®, 2010. http://digitalcommons.wku.edu/theses/232.

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The purpose of this investigation was to determine the effects of caffeine supplementation on caffeine tolerant and caffeine naïve individual’s lymphocyte counts, apoptosis and migration levels. In addition, effects of exercise on post-caffeine ingestion lymphocyte counts, apoptosis and migration levels were determined. It was hypothesized that caffeine would alter the immune system cell counts, but that exercise would be able to restore the immune system to homeostasis. Seventeen Western Kentucky University students were tested (males n=7, females n=10; n=7: caffeine tolerant= 200mg or more p

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30

Yang, Lin. "The signaling pathway of oxysterol induced apoptosis in Chinese hamster ovary (CHO)-K1 cells." [Johnson City, Tenn. : East Tennessee State University], 2002. http://etd-submit.etsu.edu/etd/theses/available/etd-0510102-161626/unrestricted/YangL062602.pdf.

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31

Rajadinakaran, Gopinath. "Next Generation Sequencing Reveals Gene Expression Patterns in the Zebrafish Inner Ear Following Growth Hormone Injection." TopSCHOLAR®, 2012. http://digitalcommons.wku.edu/theses/1197.

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Loss of hair cells due to acoustic trauma results in the loss of hearing. In humans, unlike other vertebrates, the mechanism of hair cell regeneration is not possible. The molecular mechanisms that underlie this regeneration in nonmammalian vertebrates remain elusive. To understand the gene regulation during hair cell regeneration, our previous microarray study on zebrafish inner ears found that growth hormone (GH) was significantly upregulated after noise exposure. In this current study, we utilized Next Generation Sequencing (NGS) to examine the genes and pathways that are significantly regu

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32

Zheng, Wenjing. "Fenretinide increases dihydroceramide and dihydrosphingolipids due to inhibition of dihydroceramide desaturase." Thesis, Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-07062006-164343/.

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33

Chen, Daphne Wei-chen. "Integrative modelling of glucocorticoid induced apoptosis with a systems biology approach." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/integrative-modelling-of-glucocorticoid-induced-apoptosis-with-a-systems-biology-approach(a05039a1-f3e3-44d2-959e-0fade52a28a1).html.

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Glucocorticoids (GCs) have an important role in anti-inflammation, apoptosis and immunomodulatory activity. GCs exert their effect by binding to their receptor, glucocorticoid receptor (GR), which subsequently triggers receptor dimerisation, nuclear translocation and eventually causes impact on transcriptional activity. Such regulatory mechanism is complex as it is not only controlled at the transcription level, but also at the post translational level with other contributing factors such as protein stability and cofactor recruitment. Glucocorticoids are commonly used as part of the chemothera

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34

Akudugu, John Mbabuni. "Examination of irradiated neuroblastoma and neuroepithelial cell lines for the interrelationship between cell survival, micronucleation, apoptosis and DNA repair." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/51755.

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Thesis (Ph.D.)--Stellenbosch University, 2000.<br>ENGLISH ABSTRACT: Predictive assays are of key importance in clinical radiotherapy, chemotherapy and toxicology. Prior to exposing malignant tissues to irradiation or drugs in the clinic, a good understanding of the damage response to the cytotoxic agent is required. Such information is necessary for effective planning and treatment. Regrettably however the methods which detect DNA damage, namely micronucleus, apoptosis and DNA repair assays do not rank cells according to their intrinsic survival response to cytotoxic agents. The appli

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35

Matluk, Nicholas N. "Neurotrophin Receptor-Interacting Melanoma-Associated Antigen Protein Activates Nuclear Factor Kappa Beta Repressing Bone Morphogenic Protein Induced Apoptosis Through Macrophage Migration Inhibitory Factor Expression." Fogler Library, University of Maine, 2011. http://www.library.umaine.edu/theses/pdf/MatlukN2011.pdf.

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36

Weaver, Sean. "Heterokaryon incompatibility in Aspergillus fumigatus." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/heterokaryon-incompatibility-in-aspergillus-fumigatus(c0db26be-8326-4a93-8bcb-2648069e256c).html.

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Invasive aspergillosis (IA) is associated with high mortality rates and can be difficult and expensive to treat with current drugs. The drugs used to treat IA are also associated with undesirable, and often severe, side-effects of the patient. The main causative agent of this disease is the opportunistic pathogen Aspergillus fumigatus. This study identifies genes which play a role in a fungal-specific type of programmed cell death (PCD) in A. fumigatus, known as heterokaryon incompatibility. The development of drugs specifically targeting the products of these genes could lead to fewer side-ef

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Korhonen, Laura. "Anti-Apoptotic Proteins in Nerve Cell Survival and Neurodegeneration." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5230-2/.

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Wang, Haizhen. "The C-Phycocyanin/Beta Protein Inhibits Cancer Cell Proliferation." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-04212008-155113/.

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Thesis (M.S.)--Georgia State University, 2008.<br>Title from file title page. Zhi-Ren Liu, committee chair; Delon W. Barfuss, Jenny J. Yang, committee members. Electronic text (69 p. : ill. (some col.)) : digital, PDF file. Description based on contents viewed June 11, 2008. Includes bibliographical references (p. 61-67).

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Wang, Yajie. "The Time-Course of the Effects of Growth Hormone During Zebrafish (DANIO RERIO) Auditory Hair Cell Regeneration." TopSCHOLAR®, 2012. http://digitalcommons.wku.edu/theses/1171.

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Growth hormone (GH) was upregulated in the zebrafish inner ear following sound exposure in a previous study. To identify the specific role of GH in hair cell regeneration and the possible cellular mechanisms of this regeneration, groups of zebrafish were divided into baseline (no sound exposure, no injection), buffer-injected and GH-injected groups. Buffer- and GH-injected fish were exposed to a 150 Hz tone at a source level of 179 dB re 1 μPa root mean squared (RMS) for 36 h. Phalloidin-staining was used to assess the effects of GH on hair cell bundle density; BrdU-labeling was used to assess

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40

Lindholm, Cecilia K. "Shb and its homologues : signaling in T lymphocytes and fibroblasts /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5260-4/.

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Sharp, Andrew. "The role of p53 modulation in correcting aberrant placental apoptosis in pre-eclampsia and IUGR." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-p53-modulation-in-correcting-aberrant-placental-apoptosis-in-preeclampsia-and-iugr(5234cc67-e56a-48c5-b474-1e5ae6232e5c).html.

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Pre-eclampsia and intrauterine growth restriction (IUGR) are common complications of pregnancy with significant implications for mother and fetus. The exact cause is unknown, but current theories suggest that abnormal trophoblast invasion leads to placental under perfusion and hypoxia with the generation of reactive oxygen species (ROS). A result of this insult is increased trophoblast apoptosis. The cell cycle regulator p53 has been identified in increased amounts in the trophoblast in pre-eclampsia and IUGR. It is possible that modulation of this potent apoptotic signal could improve placent

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Maire, Marie-Aline. "Inhibition de l'apoptose comme facteur de la transformation morphologique des cellules embryonnaires de hamster Syrien." Metz, 2004. http://docnum.univ-lorraine.fr/public/UPV-M/Theses/2004/Maire.Marie_Aline.SMZ0434.pdf.

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Le but de ce travail consistait d'une part, à étudier l'hypothèse qu'une défaillance des processus apoptotiques favoriserait la transformation cellulaire, et d'autre part, à élucider certains des mécanismes moléculaires de substances inhibitrices de l'apoptose. Ce travail a été réalisé sur les cellules embryonnaires de hamster Syrien, des cellules normales, diploïdes et capables de métaboliser un grand nombre de substances chimiques. Cette étude a été appliquée à trois substances, le zinc, inhibiteur de l'apoptose, le DEHP (di-2-ethylhexyl phtalate), transformant in vitro, le 2,4-D (acide 2,4-

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Paramo, Sanchez Blanca Estela. "The role of Sin1 in cell survival." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-sin1-in-cell-survival(10b70b16-0e06-405f-a89e-caaae8f5974d).html.

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Cancer and neurodegeneration are detrimental conditions associated with an inappropriate regulation of cell survival and cell death, causing compromised cells to evade death or excessive death of healthy neurons. The mammalian target of rapamycin complex 2 (mTORC2) has been implicated in the regulation of cell survival by phosphorylating the protein kinase Akt. This is dependent upon the scaffold protein Sin1, a core component of mTORC2. The requirement of Sin1 in cell survival, and in particular in neuronal survival, has not been established due to the early embryonic lethality of mice with a

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Lee, Sarah Angeline. "Curcumin Protects against Renal Ischemia by Activating the Unfolded Protein Response and Inducing HSP70." Yale University, 2009. http://ymtdl.med.yale.edu/theses/available/etd-04062009-215154/.

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The purpose of this study was to establish whether curcumin protects renal proximal tubule cells against ischemic injury, determine whether this postulated cytoprotective effect is mediated through the upregulation of HSP70, and investigate whether the mechanism by which curcumin induces HSP70 expression and confers its protective effect is through activation of the Unfolded Protein Response. LLC-PK1 cells were cultured on collagen-coated filters to mimic conditions of in vivo renal proximal tubule cells and induce cell polarization. Injury with and without curcumin treatment was studied by us

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Wachtel, Heather. "Polymorphisms and Biologic Effects of Acidic Mammalian Chitinase in Asthma." Yale University, 2009. http://ymtdl.med.yale.edu/theses/available/etd-03102009-162717/.

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In this study, we hypothesize that human acidic mammalian chitinase (AMCase) binds and is regulated by the epidermal growth factor receptor (EGFR), and that AMCase interacts with Galectin-3 (Gal-3) to mediate anti-apoptotic functions. We further hypothesize that asthma-associated polymorphisms of AMCase alter chitinase activity and modulate anti-apoptotic effects. We investigated the interactions between AMCase, Gal-3 and EGFR by establishing binding and co-expression in vitro; apoptotic effects were evaluated via Annexin V/Propidium Iodide staining. Molecular cloning was performed to generate

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Kritsiligkou, Paraskevi. "Peroxiredoxins : yeast redox switches that regulate multiple cellular pathways." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/peroxiredoxins-yeast-redox-switches-that-regulate-multiple-cellular-pathways(fbb44664-5021-4dbc-88c7-64aef8a6c045).html.

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Peroxiredoxins are small ubiquitous cysteine-containing proteins that exhibit high reactivity to hydrogen peroxide. Apart from their role as antioxidants, detoxifying hydrogen peroxide to water, peroxiredoxins have been implicated in other cellular processes, such as protein folding and signalling. Using S. cerevisiae as a model organism, we utilised a variety of techniques to examine previously unexplored links between peroxiredoxins and mitochondrial function. Firstly, we characterised the role of Gpx3 in yeast mitochondria. Proteomic work revealed the presence of Gpx3 in the mitochondrial i

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Serafin, Antonio Mendes. "Cell biological responses of prostatic tumour cell lines to irradiation and anticancer drugs." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53321.

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Thesis (PhD)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: The "classic" prostate cell lines, DU145, PC-3 and LNCaP, have served as a valuable cell biological model for research into prostate cancer. However, their relevance may be limited because they derive from metastatic, and not from primary normal and tumour epithelium. The cell lines (1532T, 1535T, 1542T, 1542N and BPH-l) have been derived from primary benign and malignant human tumour prostate epithelium and may be more representative. Using these cell lines I have examined the role of basic cell damage responses (repair

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Van, den Heever Martine. "A comparison of the effect of curcumin treatment on apoptosis, necrosis and autophagy in a MCF-7 mammary adenocarcinoma and a MCF-12A healthy mammary epithelial cell line." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/2970.

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Thesis (MSc (Physiological Sciences))--University of Stellenbosch, 2009.<br>Breast cancer is currently the primary cause of cancer-related death in women worldwide. Conventional treatments such as radiation and chemotherapy have many deleterious and long lasting side-effects, some of which are permanent, such as infertility. As certain tumour cells can also acquire resistance to chemotherapy, the need for the development of a less severe, yet more effective, targeted anti-cancer treatment exists. Curcumin, a plant polyphenol from Curcuma longa, has long been thought to possess antitumour

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Berrou, Ilhem. "ROS & energy production pathways in the determination of resistance/sensitivity to glucocorticoids-induced apoptosis in acute lymphoblastic leukaemia." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/ros-and-energy-production-pathways-in-the-determination-of-resistance-sensitivity-to-glucocorticoidsinduced-apoptosis-in-11acute-lymphoblastic-leukaemia(910f02ec-2986-4f9f-ba2b-53a38921f265).html.

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Glucocorticoids have long been used in the treatment of acute lymphoblastic leukaemia due to their ability to cause cell cycle arrest and apoptosis of lymphoid cells. However, some patients do not respond to glucocorticoid treatment and the majority, who initially respond, may relapse upon prolonged hormone treatment. The inefficiency of the treatment is mainly attributed to the gradual loss of the cellular sensitivity to glucocorticoid-induced apoptosis. Therefore, the need to understand the molecular mechanisms of resistance/ sensitivity of acute lymphoblastic leukaemia cells to glucocortico

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Marklund, Niklas. "The role of reactive oxygen species in traumatic brain injury : Experimental studies in the rat." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5053-9/.

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