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Relevant bibliographies by topics / Apoptosomes / Dissertations / Theses

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Dissertations / Theses on the topic 'Apoptosomes'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Twiddy, Davina Deborah. "Molecular and proteomic characterisation of the ~700 kDa apoptosome." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/30776.

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The apoptosome is a caspase-activating complex consisting of Apaf-1, caspase-9 and cytochrome c, which is essential for the induction of stress-mediated apoptosis. This complex ranges in size from ~ 700 kDa to ~ 1.4 MDa, possibly due to the stable association of modulatory proteins. In the current study I employed two strategies to isolate and characterise the active ~ 700 kDa apoptosome in vitro. Firstly, I used GST-Casp91-130, which binds to the CARD domain of Apaf-1 in a dATP and cytochrome c-dependent manner, to affinity-purify an apoptosome containing only Apaf-1XL and cytochrome c. This

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2

Langlais, Claudia. "Characterisation of the ~700kDa apoptosome complex from THP.1 cells." Thesis, University of Leicester, 2002. http://hdl.handle.net/2381/30765.

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Apoptosis or programmed cell death is a process involving the regulated self-destruction of a cell. Execution of the apoptotic programme requires the hierarchical activation of a family of proteases, the caspases. Here, I describe the characterisation and purification of the apoptosome, a ~700kDa caspase activating complex. Gel filtration of dATP-activated THP.1 cell lysates showed that effector caspase activity is assessed with a large complex, the apoptosome, which contains Apaf-1 and active caspases-9, -3 and -7. Further analysis revealed two large complexes, a biologically inactive ~1.4MDa

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3

Malet, Engra Gema. "Identificación de moduladores del apoptosoma mediante química combinatoria." Doctoral thesis, Universitat de València, 2005. http://hdl.handle.net/10803/9529.

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La apoptosis es un proceso importante en una amplia variedad sistemas biológicos, incluyendo el recambio celular normal, el sistema inmunológico y el desarrollo embrionario. La apoptosis inadecuada está implicada en muchas enfermedades incluyendo enfermedades neurodegenerativas tales como las enfermedades de Alzheimer y Huntington, isquemia, desórdenes autoinmunes y varias formas de cáncer. La familia de proteínas Bcl-2 abarca una clase de estructuras homólogas que sirven para inhibir o para activar la apoptosis en un proceso intrincado y a su vez, bien orquestado. Los estímulos apoptósicos i

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4

Henty, Kristen M. "A role for neuroglobin in the inhibition of cytochrome c-mediated apoptosome formation." Thesis, University of Auckland, 2011. http://hdl.handle.net/2292/8268.

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The mitochondrial pathway of apoptosis is an important mediator of cell death in many human diseases. A key event in this pathway is permeabilisation of the outer mitochondrial membrane and subsequent release of the heme-protein cytochrome c from mitochondria into the cytosol. Thereafter, cytosolic cytochrome c mediates the formation of the apoptosome complex, which cleaves the initiator caspase 9, thereby activating the caspase signalling cascade. Apoptosome formation is thought to require cytochrome c which has its heme iron in the ferric form. Neuroglobin, a recently discovered globi

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5

Cagnol, Sébastien. "Contrôle de la mort cellulaire par la voie des MAPK1/3 (ERK2/1)." Phd thesis, Université de Nice Sophia-Antipolis, 2005. http://tel.archives-ouvertes.fr/tel-00104792.

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La mort cellulaire programmée ou apoptose est un mécanisme conservé chez les eucaryotes multicellulaires qui contribue au développement embryonnaire et à l'homéostasie cellulaire des organismes. Dans les cellules vivantes, l'activité des protéases qui exécutent le programme de mort cellulaire, les caspases, est contrôlée par des signaux de survie provenant de l'environnement cellulaire. Les caspases initiatrices de l'apoptose régulée par l'environnement, la caspase 9 et la caspase 8 sont activées respectivement par l'apoptosome et par les récepteurs de mort. Les signaux environnementaux, parmi

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6

Marina, García Noemí. "Complexos reguladors amb participació de proteïnes de la família NOD: estudis sobre la interacció entre Citocrom c i Apaf-1 a l'apoptosoma." Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/1001.

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L'apoptosi o mort cel.lular programada és un procés central al desenvolupament, homeòstasi cel.lular, la resposta a l'estrés, l'envelliment i diferents malalties, als organismes eucariotes pluricel.lulars. Una de les vies que regula l'activació de l'apoptosi és la via intrinseca mitocondrial, a la que el citocrom c (Cit c), alliberat des de la mitocòndria en reposta a un estímul proapoptòtic, en presència de dATP indueix l'oligomerizació d'Apaf-1 (Apoptotic protease activating factor-1) i posterior reclutament de la caspasa-9, conduint a la formació del complex macromolecular activador de l'ap

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7

Kamber, Kaya Hatem E. "Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation." eScholarship@UMMS, 2001. http://escholarship.umassmed.edu/gsbs_diss/885.

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Apoptosis is a programmed cell death mechanism that is evolutionary conserved from worms to humans. Apoptosis is mediated by initiator and effector caspases. The initiator caspases carry long pro-domains for their interaction with scaffolding proteins to form a cell-death platform, which is essential for their activation. Activated initiator caspases then cleave effector caspases that execute cell death through cleaving downstream targets. In addition to their apoptotic function, caspases also participate in events where caspase activity is not required for cell killing, but for regulating oth

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8

Kamber, Kaya Hatem E. "Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/885.

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Apoptosis is a programmed cell death mechanism that is evolutionary conserved from worms to humans. Apoptosis is mediated by initiator and effector caspases. The initiator caspases carry long pro-domains for their interaction with scaffolding proteins to form a cell-death platform, which is essential for their activation. Activated initiator caspases then cleave effector caspases that execute cell death through cleaving downstream targets. In addition to their apoptotic function, caspases also participate in events where caspase activity is not required for cell killing, but for regulating oth

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9

Kiechle, Tamara. "Apoptose als möglicher Pathomechanismus der Nervenzelldegeneration beim M. Huntington immunhistochemische und Western-Blot-Untersuchung menschlichen und transgenen murinen Post-mortem-Gehirngewebes zur Stadien-abhängigen Bildung der Komponenten des Apoptosom-Komplexes /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974902020.

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10

Kim, Hyun-Eui. "Biochemical analysis of apoptosome formation." 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=215.

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11

Kim, Jiyeon. "Regulation of the Apoptosome in Cancer." Diss., 2012. http://hdl.handle.net/10161/5787.

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<p>Apoptosis is a cellular suicide program that can be initiated by various genotoxic and cytotoxic stimuli. In many cases, such cell damaging agents promote cell death through the intrinsic apoptotic pathway by triggering mitochondrial cytochrome <italic>c</italic> release and subsequent caspase activation. Cytosolic cytochrome <italic>c</italic> is directly responsible for initiating formation of the caspase-activating apoptosome, which plays a crucial role in the apoptotic process. Given the importance of cellular fate, apoptosis is tightly controlled by a balance between survival and death

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12

Malladi, Srinivas. "Mechanistic insights into apoptosome dependent caspase-9 processing and activation." Thesis, 2010. http://hdl.handle.net/2152/ETD-UT-2010-05-791.

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During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound in order to retain significant catalytic activity. Nevertheless, in apoptotic cells, the vast majority of processed caspase-9 is paradoxically observed outside of the complex. We demonstrate herein that apoptosome-mediated cleavage of procaspase-9 occurs exclusively through a CARD-displacement mechanism, so that unlike the effector procaspase-3, procaspase-9 cannot be processed by the apoptosome as a typical substrate. Indeed, procaspase-9 possessed higher affinity for the ap

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13

Su, Tsung-Wei, and 蘇琮為. "Structural Insights into DD-Fold Assembly and Caspase-9 Activation by the Apaf-1 Apoptosome." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/q69t93.

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博士<br>國立臺灣大學<br>生化科學研究所<br>106<br>Death domain (DD)-fold assemblies play a crucial role in regulating the signaling to cell survival or death. Here we report the crystal structure of the caspase recruitment domain (CARD)-CARD disk of the human apoptosome. The structure surprisingly reveals that three 1:1 Apaf-1: procaspase-9 CARD protomers form a novel helical DD-fold assembly on the heptameric wheel-like platform of the apoptosome. The small-angle X-ray scattering and multi-angle light scattering data also support that three protomers could form an oligomeric complex similar to the crystal st

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14

Parrish, Amanda Baumann. "Regulation of Apoptosis Following Mitochondrial Cytochrome c Release." Diss., 2010. http://hdl.handle.net/10161/2294.

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<p>Many pro-apoptotic signals trigger mitochondrial cytochrome c release, leading to caspase activation and ultimate cellular breakdown. Cell survival pathways, including the mitogen-activated protein kinase (MAPK) cascade, promote cell viability both by impeding mitochondrial cytochrome c release and by inhibiting subsequent activation of caspases. Cytosolic cytochrome c is directly responsible for initiating formation of the caspase-activating apoptosome, which, in many cell types, plays a crucial role in the apoptotic process. Given the important role of cytochrome c in dismantling the dyin

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15

Kiechle, Tamara [Verfasser]. "Apoptose als möglicher Pathomechanismus der Nervenzelldegeneration beim M. Huntington : immunhistochemische und Western-Blot-Untersuchung menschlichen und transgenen murinen Post-mortem-Gehirngewebes zur Stadien-abhängigen Bildung der Komponenten des Apoptosom-Komplexes / Tamara Kiechle." 2005. http://d-nb.info/974902020/34.

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