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Journal articles on the topic 'APS, Complement System, Coagulation Cascade'

Author: Grafiati

Published: 11 March 2023

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1

Panebianco, Lauren M., and Teresa Gentile. "The Role of Monitoring Complement Levels in Catastrophic Antiphospholipid Syndrome: A Case Series of 4 Patients." Blood 134, Supplement_1 (2019): 4872. http://dx.doi.org/10.1182/blood-2019-128297.

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Introduction: Catastrophic antiphospholipid syndrome (CAPS) is characterized by multiple intravascular thrombotic events occurring over a short time period in the presence of persistently detectable antiphospholipid antibodies (APLA). Despite its clinical significance with mortality rate of 40-50%, the underlying pathophysiology remains somewhat enigmatic. More recent focus on the complement system as it interacts with the coagulation cascade has led to off-label use of eculizumab, a humanized monoclonal antibody against C5, in the treatment of CAPS. Consequently, monitoring of disease status

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Liang, Yan, Shang-Bo Xie, Chang-Hao Wu, et al. "Coagulation cascade and complement system in systemic lupus erythematosus." Oncotarget 9, no. 19 (2017): 14862–81. http://dx.doi.org/10.18632/oncotarget.23206.

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Fletcher-Sandersjöö, Alexander, Marc Maegele, and Bo-Michael Bellander. "Does Complement-Mediated Hemostatic Disturbance Occur in Traumatic Brain Injury? A Literature Review and Observational Study Protocol." International Journal of Molecular Sciences 21, no. 5 (2020): 1596. http://dx.doi.org/10.3390/ijms21051596.

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Despite improvements in medical triage and tertiary care, traumatic brain injury (TBI) remains associated with significant morbidity and mortality. Almost two-thirds of patients with severe TBI develop some form of hemostatic disturbance, which contributes to poor outcome. In addition, the complement system, which is abundant in the healthy brain, undergoes significant intra- and extracranial amplification following TBI. Previously considered to be structurally similar but separate systems, evidence of an interaction between the complement and coagulation systems in non-TBI cohorts has accumul

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Berkowitz, Shani, Joab Chapman, Amir Dori, Shany Guly Gofrit, Nicola Maggio, and Efrat Shavit-Stein. "Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems." Biomedicines 9, no. 12 (2021): 1950. http://dx.doi.org/10.3390/biomedicines9121950.

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Complement and coagulation are both key systems that defend the body from harm. They share multiple features and are similarly activated. They each play individual roles in the systemic circulation in physiology and pathophysiology, with significant crosstalk between them. Components from both systems are mapped to important structures in the central nervous system (CNS) and peripheral nervous system (PNS). Complement and coagulation participate in critical functions in neuronal development and synaptic plasticity. During pathophysiological states, complement and coagulation factors are upregu

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Gavriilaki, Eleni, Akrivi Chrysanthopoulou, Ioanna Sakellari, et al. "Linking Complement Activation, Coagulation, and Neutrophils in Transplant-Associated Thrombotic Microangiopathy." Thrombosis and Haemostasis 119, no. 09 (2019): 1433–40. http://dx.doi.org/10.1055/s-0039-1692721.

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AbstractTransplant-associated thrombotic microangiopathy (TA-TMA) is a severe and life-threatening complication of hematopoietic cell transplantation (HCT) that often coincides with graft-versus-host-disease (GVHD). Although endothelial damage seems to be the common denominator for both disorders, the role of complement system, neutrophils, and coagulation has not been clarified. In an effort to distinguish the pathogenesis of TA-TMA from GVHD, we evaluated markers of complement activation, neutrophil extracellular trap (NET) release, endothelial damage, and activation of coagulation cascade i

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Arnout, J. "Mechanism of action of Lupus anticoagulants." Hämostaseologie 21, no. 02 (2001): 44–49. http://dx.doi.org/10.1055/s-0037-1619504.

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SummaryThe antiphospholipid syndrome (APS) is defined as the association of antiphospholipid antibodies (aPL) with thrombosis, fetal loss or thrombocytopenia. Some aPL can be detected via coagulation assays where they present as an aspecific inhibitor termed the lupus anticoagulant (LA). Others can be measured via direct binding to cardiolipin and are termed anticardiolipin antibodies. aPL found in APS patients bind to a variety of PL-binding proteins such as beta-2-glycoprotein I (β2GPI) and prothrombin bound to PL surfaces. LA retard coagulation reactions in vitro by forming stable bivalent

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Huber, Silke, Mariam Massri, Marco Grasse, et al. "Systemic Inflammation and Complement Activation Parameters Predict Clinical Outcome of Severe SARS-CoV-2 Infections." Viruses 13, no. 12 (2021): 2376. http://dx.doi.org/10.3390/v13122376.

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Overactivation of the complement system has been characterized in severe COVID-19 cases. Complement components are known to trigger NETosis via the coagulation cascade and have also been reported in human tracheobronchial epithelial cells. In this longitudinal study, we investigated systemic and local complement activation and NETosis in COVID-19 patients that underwent mechanical ventilation. Results confirmed significantly higher baseline levels of serum C5a (24.5 ± 39.0 ng/mL) and TCC (11.03 ± 8.52 µg/mL) in patients compared to healthy controls (p < 0.01 and p < 0.0001, respectively)

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Mutch, Nicola J. "Polyphosphate as a haemostatic modulator." Biochemical Society Transactions 44, no. 1 (2016): 18–24. http://dx.doi.org/10.1042/bst20150207.

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Platelets are small anuclear cells that play a central role in haemostasis. Platelets become activated in response to various stimuli triggering release of their granular contents into the surrounding milieu. One of these types of granules, termed dense granules, have been found to contain polyphosphate (polyP) in addition to other inorganic biomolecules, such as serotonin, ADP, ATP, PPi. Individuals deficient in dense granules exhibit bleeding tendencies, emphasizing their importance in haemostasis. Platelet polyP is of a relatively defined size, approximately 60–100 phosphate monomers in len

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Tiwari, Ritudhwaj, Anurag R. Mishra, Flora Mikaeloff, et al. "In silico and in vitro studies reveal complement system drives coagulation cascade in SARS-CoV-2 pathogenesis." Computational and Structural Biotechnology Journal 18 (2020): 3734–44. http://dx.doi.org/10.1016/j.csbj.2020.11.005.

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Bazargani, Farhan, Russell P. Rother, and Magnus Braide. "The Roles of Complement Factor C5a and CINC-1 in Glucose Transport, Ultrafiltration, and Neutrophil Recruitment during Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 26, no. 6 (2006): 688–96. http://dx.doi.org/10.1177/089686080602600614.

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Background In a recent experimental study, we showed that low molecular weight heparin improved ultrafiltration and blocked complement activation and coagulation in a single peritoneal dialysis (PD) dwell. Objective The aim of the present study was to evaluate the possible contribution of the complement factor C5a and the potential interactions between C5a, the coagulation system, and cytokines of the interleukin (IL)-8 family (cytokine-induced neutrophil chemoattractant; CINC-1). Methods Nonuremic rats were exposed through an indwelling catheter to a single dose of 20 mL glucose- (2.5%) based

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Cugno, Massimo, and Angelo Agostini. "Influence of Contact System Deficiencies during Cardiopulmonary Bypass." Thrombosis and Haemostasis 85, no. 02 (2001): 191–92. http://dx.doi.org/10.1055/s-0037-1615673.

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SummaryAs a result of the expanding indications for cardiopulmonary bypass (CPB) there is a growing number of patients undergoing this procedure who are at high surgical risk, and increasing efforts to investigate the mechanisms involved in CPB complications are warranted. Blood contact with foreign surfaces triggers systemic inflammatory response and may induce coagulation (1), this is believed to be responsible of most of the unwanted effects associated with CPB. During this procedure, contact phase activation occurs (2), involving factor XII (FXII), prekallikrein (PK) and high molecular wei

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Doszpoly, Andor, Fernando de la Cuesta, Estrella Lopez-Gordo, Cécile Bénézech, Stuart A. Nicklin, and Andrew H. Baker. "Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent Neutralization In Vitro and In Vivo." Viruses 11, no. 7 (2019): 616. http://dx.doi.org/10.3390/v11070616.

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Human adenovirus 5 (HAdV-5) is used as a vector in gene therapy clinical trials, hence its interactions with the host immune system have been widely studied. Previous studies have demonstrated that HAdV-5 binds specifically to murine coagulation factor X (mFX), inhibiting IgM and complement-mediated neutralization. Here, we examined the physical binding of immune components to HAdV-5 by nanoparticle tracking analysis, neutralization assays, mass spectrometry analysis and in vivo experiments. We observed that purified mouse Immunoglobulin M (IgM) antibodies bound to HAdV-5 only in the presence

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Ayass, Mohamad Ammar, Wanying Cao, Jin Zhang, et al. "Noninvasive nasopharyngeal proteomics of COVID-19 patient identify abnormalities related to complement and coagulation cascade and mucosal immune system." PLOS ONE 17, no. 9 (2022): e0274228. http://dx.doi.org/10.1371/journal.pone.0274228.

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Serum or plasma have been the primary focus of proteomics studies for COVID-19 to identity biomarkers and potential drug targets. The nasal mucosal environment which consists of lipids, mucosal immune cells, and nasal proteome, has been largely neglected but later revealed to have critical role combating SARS-CoV-2 infection. We present a bottom-up proteomics investigation of the host response to SARS-CoV-2 infection in the nasopharyngeal environment, featuring a noninvasive approach using proteins in nasopharyngeal swabs collected from groups of 76 SARS-CoV-2 positive and 76 negative patients

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Rekker, Kadri, Merli Saare, Elo Eriste, et al. "High-throughput mRNA sequencing of stromal cells from endometriomas and endometrium." Reproduction 154, no. 1 (2017): 93–100. http://dx.doi.org/10.1530/rep-17-0092.

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The aetiology of endometriosis is still unclear and to find mechanisms behind the disease development, it is important to study each cell type from endometrium and ectopic lesions independently. The objective of this study was to uncover complete mRNA profiles in uncultured stromal cells from paired samples of endometriomas and eutopic endometrium. High-throughput mRNA sequencing revealed over 1300 dysregulated genes in stromal cells from ectopic lesions, including several novel genes in the context of endometriosis. Functional annotation analysis of differentially expressed genes highlighted

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Scambi, C., D. Biasi, S. Ugolini, et al. "AB0125 The crosstalk between the complement system and the coagulation cascade in the antiphospholipid syndrome. preliminary data from basic research." Annals of the Rheumatic Diseases 72, Suppl 3 (2013): A823.3—A824. http://dx.doi.org/10.1136/annrheumdis-2013-eular.2448.

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Maroney, Susan, Julie Peterson, Wes Zwifelhofer, et al. "Plasma Proteolytic Cascade Activation during Neonatal Cardiopulmonary Bypass Surgery." Thrombosis and Haemostasis 118, no. 09 (2018): 1545–55. http://dx.doi.org/10.1055/s-0038-1667198.

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Background Neonates undergoing cardiopulmonary bypass (CPB) surgery to correct congenital heart defects often experience excessive bleeding. Exposure of blood to artificial materials during CPB may activate coagulation, complement and inflammatory pathways. In addition, the surgical stress placed on the haemostatic system may result in cross-activation of other plasma proteolytic cascades, which could further complicate physiological responses to the surgical procedure and post-operative recovery. Plasma protease inhibitors undergo distinct conformational changes upon interaction with protease

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Scholz, Tim, Rigmor Solberg, Cecilie Okkenhaug, et al. "Veno-venous bypass in liver transplantation: heparin-coated perfusion circuits reduce the activation of humoral defense systems in an in vitro model." Perfusion 16, no. 4 (2001): 285–92. http://dx.doi.org/10.1177/026765910101600404.

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We studied the effects of bypass circuit surface heparinization on kallikrein-kinin, coagulation, fibrinolytic and complement activation in a closed model system for simulating veno-venous bypass (VVBP) in orthotopic liver transplantation (OLT). The circuits were identical to those in routine use during clinical OLT in our institution. Fresh whole human blood diluted 1: 2 with Ringer’s acetate was circulated at a non-pulsatile flow (2 l/min) and at a constant temperature (37.5°C) for 12 h. In 10 experiments, the entire inner surface of the circuits was coated with end-point attached heparin (H

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Jarczak, Dominik, Stefan Kluge, and Axel Nierhaus. "Use of Intravenous Immunoglobulins in Sepsis Therapy—A Clinical View." International Journal of Molecular Sciences 21, no. 15 (2020): 5543. http://dx.doi.org/10.3390/ijms21155543.

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Sepsis is a life-threatening organ dysfunction, defined by a dysregulated host immune response to infection. During sepsis, the finely tuned system of immunity, inflammation and anti-inflammation is disturbed in a variety of ways. Both pro-inflammatory and anti-inflammatory pathways are upregulated, activation of the coagulation cascade and complement and sepsis-induced lymphopenia occur. Due to the manifold interactions in this network, the use of IgM-enriched intravenous immunoglobulins seems to be a promising therapeutic approach. Unfortunately, there is still a lack of evidence-based data

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Hoffmeister, H. M., M. Ruf, H. P. Wendel, et al. "Activation of the contact phase of the coagulation, of the kinin system and of the complement cascade by streptokinase in acute myocardial infarction." Fibrinolysis and Proteolysis 11 (August 1997): 149–52. http://dx.doi.org/10.1016/s0268-9499(97)80089-6.

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Dahlbäck, Björn. "Protein S and C4b-Binding Protein: Components Involved in the Regulation of the Protein C Anticoagulant System." Thrombosis and Haemostasis 66, no. 01 (1991): 049–61. http://dx.doi.org/10.1055/s-0038-1646373.

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SummaryThe protein C anticoagulant system provides important control of the blood coagulation cascade. The key protein is protein C, a vitamin K-dependent zymogen which is activated to a serine protease by the thrombin-thrombomodulin complex on endothelial cells. Activated protein C functions by degrading the phospholipid-bound coagulation factors Va and VIIIa. Protein S is a cofactor in these reactions. It is a vitamin K-dependent protein with multiple domains. From the N-terminal it contains a vitamin K-dependent domain, a thrombin-sensitive region, four EGF)epidermal growth factor (EGF)-lik

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Satué, K., J. C. Gardón, and A. Muñoz. "Interpretation of Platelets in The Horse." Journal of Hematology Research 4 (February 27, 2017): 19–25. http://dx.doi.org/10.12974/2312-5411.2017.04.3.

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Currently we can consider that, in addition to its role in hemostasis, platelets also participate in other important processes such as thrombosis, inflammation, tissue remodeling and the innate defense mechanisms. The hemostatic activity of platelets includes different events to stop bleeding. Within these functions we can mention the adhesion to the endothelium of the affected blood vessel, the activation, the aggregation, and the release of substances that initiate hemostatic events, and also the providing a phospholipid surface for activation of numerous coagulation factors. Similarly, plat

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Gustafson, Elisabet, Sana Asif, Huda Kozarcanin, et al. "Control of IBMIR Induced by Fresh and Cryopreserved Hepatocytes by Low Molecular Weight Dextran Sulfate versus Heparin." Cell Transplantation 26, no. 1 (2017): 71–81. http://dx.doi.org/10.3727/096368916x692609.

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Rapid destruction of hepatocytes after hepatocyte transplantation has hampered the application of this procedure clinically. The instant blood-mediated inflammatory reaction (IBMIR) is a plausible underlying cause for this cell loss. The present study was designed to evaluate the capacity of low molecular weight dextran sulfate (LMW-DS) to control these initial reactions from the innate immune system. Fresh and cryopreserved hepatocytes were tested in an in vitro whole-blood model using ABO-compatible blood. The ability to elicit IBMIR and the capacity of LMW-DS (100 μg/ml) to attenuate the de

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Elek, N., S. Sandor, G. Balazs, and P. Dahlem. "Pediatric Sepsis: Genetic Considerations." Journal of Child Science 07, no. 01 (2017): e76-e88. http://dx.doi.org/10.1055/s-0037-1603803.

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AbstractThe mortality of childhood sepsis continues to be rather high. When it comes to prevention and adequate therapy, individual differences and genetic alterations are becoming more and more important. These may affect molecules involved in pathogen recognition (e.g., lipopolysaccharide-binding protein, mannose-binding lectin, bactericidal/permeability-increasing protein, Toll-like receptors), signal transduction pathways (e.g., cRel), proinflammatory (e.g., tumor necrosis factor-α, interleukin-1 [IL-1], IL-6, IL-8) as well as anti-inflammatory cytokines (e.g., IL-4, IL-10, IL-1 receptor a

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Ratajczak, Mariusz Z., and Janina Ratajczak. "Innate Immunity Communicates Using the Language of Extracellular Microvesicles." Stem Cell Reviews and Reports 17, no. 2 (2021): 502–10. http://dx.doi.org/10.1007/s12015-021-10138-6.

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AbstractThe innate immunity system and extracellular microvesicles (ExMVs) both emerged early in the evolution of life, which is why its innate immunity cellular arm and its soluble-component arm learned, understood, and adapted to the “language” of ExMVs. This was most likely the first language of cell–cell communication during evolution, which existed before more specific intercellular crosstalk involving specific ligands and receptors emerged. ExMVs are involved in several processes in the body, including immune and coagulation responses, which are part of inflammation. In this review we wi

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Tu, Chengcheng, Feng Tao, Ying Qin, et al. "Serum proteins differentially expressed in early- and late-onset preeclampsia assessed using iTRAQ proteomics and bioinformatics analyses." PeerJ 8 (September 1, 2020): e9753. http://dx.doi.org/10.7717/peerj.9753.

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Background Preeclampsia remains a serious disorder that puts at risk the lives of perinatal mothers and infants worldwide. This study assessed potential pathogenic mechanisms underlying preeclampsia by investigating differentially expressed proteins (DEPs) in the serum of patients with early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE) compared with healthy pregnant women. Methods Blood samples were collected from four women with EOPE, four women with LOPE, and eight women with normal pregnancies, with four women providing control samples for each preeclampsia group. Serum prot

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Jacobi, Judith. "The pathophysiology of sepsis—2021 update: Part 1, immunology and coagulopathy leading to endothelial injury." American Journal of Health-System Pharmacy 79, no. 5 (2021): 329–37. http://dx.doi.org/10.1093/ajhp/zxab380.

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Abstract Purpose To provide an overview of current literature on the pathophysiology of sepsis, with a focus on mediators of endothelial injury and organ dysfunction. Summary Sepsis is a dysregulated response to infection that triggers cascades of interconnected systems. Sepsis has been a significant cause of mortality worldwide, and the recent viral pandemic that may produce severe sepsis and septic shock has been a major contributor to sepsis-related mortality. Understanding of the pathophysiology of sepsis has changed dramatically over the last several decades. Significant insight into the

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Montilla, Marcela, Andrea Liberato, Pablo Ruiz-Ocaña, et al. "Proinflammatory Polyphosphate Increases in Plasma of Obese Children with Insulin Resistance and Adults with Severe Type 2 Diabetes." Nutrients 14, no. 21 (2022): 4601. http://dx.doi.org/10.3390/nu14214601.

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Obesity increases the risk of insulin resistance and type 2 diabetes through increased inflammation at cellular and tissue levels. Therefore, study of the molecular elements involved in obesity-related inflammation may contribute to preventing and controlling it. Inorganic polyphosphate is a natural phosphate polymer that has recently been attracting more attention for its role in inflammation and hemostasis processes. Polyphosphates are one of the main constituents of human platelets, which are secreted after platelet activation. Among other roles, they interact with multiple proteins of the

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Adamiak, Mateusz, Malwina Suszynska, Ahmed Abdel-Latif, et al. "Novel Evidence That the Mannan-Binding Lectin (MBL) Pathway of Complement Activation Plays a Pivotal Role in Triggering Mobilization of Hematopoietic Stem/Progenitor Cells By Activation of Both the Complement and Coagulation Cascades." Blood 128, no. 22 (2016): 3371. http://dx.doi.org/10.1182/blood.v128.22.3371.3371.

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Abstract Background . The complement cascade (ComC), which is part of the innate immune system, exerts several pleiotropic effects, and, as we have demonstrated, it is required for mobilization of hematopoietic stem/progenitor cells (HSPCs) during infection or tissue/organ injury as well as in response to administration of pharmacological mobilizing agents, such as G-CSF or AMD3100 (Blood 2004, 103, 2071-2078). The ComC is activated by three pathways: the classical, mannan-binding lectin (MBL), and alternative pathways. Activation of the ComC and generation of cleavage fragments of the fifth c

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Lim, Jongwon, and Suhee Hong. "Transcriptome Analysis in the Head Kidney of Rainbow Trout (Oncorhynchus mykiss) Immunized with a Combined Vaccine of Formalin-Inactivated Aeromonas salmonicida and Vibrio anguillarum." Vaccines 9, no. 11 (2021): 1234. http://dx.doi.org/10.3390/vaccines9111234.

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This study aimed to identify the molecular mechanisms regulated by a combined vaccine against Aeromonas salmonicida and Vibrio anguillarum (O1 serotype). These bacteria cause furunculosis and vibriosis, respectively, and are associated with a high mortality in rainbow trout in Korea. The vaccine upregulated gene expression of TCRα, T-bet, sIgM, and mIgM, markers of an activated adaptive immune response. On days 1, 3, and 5, transcriptome analysis revealed 862 (430 up- and 432 downregulated), 492 (204 up- and 288 downregulated), and 741 (270 up- and 471 downregulated) differentially expressed g

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Bertholim, Luciana, Alison F. A. Chaves, Ana K. Oliveira, et al. "Systemic Effects of Hemorrhagic Snake Venom Metalloproteinases: Untargeted Peptidomics to Explore the Pathodegradome of Plasma Proteins." Toxins 13, no. 11 (2021): 764. http://dx.doi.org/10.3390/toxins13110764.

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Hemorrhage induced by snake venom metalloproteinases (SVMPs) is a complex phenomenon that involves capillary disruption and blood extravasation. HF3 (hemorrhagic factor 3) is an extremely hemorrhagic SVMP of Bothrops jararaca venom. Studies using proteomic approaches revealed targets of HF3 among intracellular and extracellular proteins. However, the role of the cleavage of plasma proteins in the context of the hemorrhage remains not fully understood. The main goal of this study was to analyze the degradome of HF3 in human plasma. For this purpose, approaches for the depletion of the most abun

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Jiang, Chao, Hengtao Guo, Zhiying Zhang, et al. "Molecular, Pathological, Clinical, and Therapeutic Aspects of Perihematomal Edema in Different Stages of Intracerebral Hemorrhage." Oxidative Medicine and Cellular Longevity 2022 (September 17, 2022): 1–38. http://dx.doi.org/10.1155/2022/3948921.

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Acute intracerebral hemorrhage (ICH) is a devastating type of stroke worldwide. Neuronal destruction involved in the brain damage process caused by ICH includes a primary injury formed by the mass effect of the hematoma and a secondary injury induced by the degradation products of a blood clot. Additionally, factors in the coagulation cascade and complement activation process also contribute to secondary brain injury by promoting the disruption of the blood-brain barrier and neuronal cell degeneration by enhancing the inflammatory response, oxidative stress, etc. Although treatment options for

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Demichev, Vadim, Pinkus Tober-Lau, Tatiana Nazarenko, et al. "A proteomic survival predictor for COVID-19 patients in intensive care." PLOS Digital Health 1, no. 1 (2022): e0000007. http://dx.doi.org/10.1371/journal.pdig.0000007.

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Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only limited performance for predicting the survival of severely ill COVID-19 patients. Additional tools are also needed to monitor treatment, including experimental therapies in clinical trials. Comprehensively capturing human physiology, we speculated that proteomics in combination with new data-driven analysis strategies could produce a new generation of progno

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Aggarwal, Manisha, Janitta Kundaikar, Dinesh Manchikanti, et al. "Gall bladder carcinoma associated with anticoagulation-resistant, progressive, multi-focal venous thrombosis and gangrene of all limbs: a case report and review of literature." International Surgery Journal 8, no. 5 (2021): 1625. http://dx.doi.org/10.18203/2349-2902.isj20211844.

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Cancer being a prothrombotic state, frequently has vascular complications, venous thrombosis, embolism, recurrent venous thromboembolism and a high frequency of anticoagulant failure. We present a rare case of anticoagulant-resistant, progressive, multifocal venous thrombosis and gangrene in all four limbs in a patient with carcinoma gallbladder. A 49 year old lady with locally advanced gallbladder cancer who had been on routine perioperative deep venous thrombosis (DVT) prophylaxis presented two months later with deep venous thrombosis of both lower limbs progressing to venous gangrene of bot

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Spichiger, Carlos, Claudia Torres-Farfan, Hugo A. Galdames, Natalia Mendez, Pamela Alonso-Vazquez, and Hans G. Richter. "Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver." Physiological Genomics 47, no. 12 (2015): 621–33. http://dx.doi.org/10.1152/physiolgenomics.00023.2015.

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Recent reports account for altered metabolism in adult offspring from pregnancy subjected to abnormal photoperiod, suggesting fetal programming of liver physiology. To generate a pipeline of subsequent mechanistic experiments addressing strong candidate genes, here we investigated the effects of constant gestational light on the fetal liver transcriptome. At 10 days of gestation, dams were randomized in two groups ( n = 7 each): constant light (LL) and normal photoperiod (12 h light/12 h dark; LD). At 18 days of gestation, RNA was isolated from the fetal liver and subjected to DNA microarray (

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Borkowska, Sylwia, Malwina Suszynska, Janina Ratajczak, and Mariusz Z. Ratajczak. "Mice Deficient in the Fifth Complement Cascade Protein (C5) Do Not Display Circadian Changes in the Number of Circulating Hematopoietic Stem/Progenitor Cells (HSPCs) in Peripheral Blood (PB)—evidence for the Pivotal Role of the Distal Part of the Complement Cascade in Inducing the Circadian Release of HSPCs into PB." Blood 124, no. 21 (2014): 1122. http://dx.doi.org/10.1182/blood.v124.21.1122.1122.

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Abstract Introduction. Activation of three ancient serum proteolytic cascades, the complement cascade (ComC), the coagulation cascade (CoaC), and the fibrynolytic cascade (FibC), is essential for release of hematopoietic stem progenitor cells (HSPCs) from bone marrow (BM) into peripheral blood (PB) during stress- or pharmacology-induced mobilization (Leukemia 2014,doi:10.1038/leu.2014.115). On the other hand, it has been convincingly demonstrated that there is a circadian oscillation in the number of circulating HSPCs in PB, with the peak occurring in the early morning hours and the nadir at n

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Coppola, Ludovico, Salvatore Guastafierro, Giovanni Verrazzo, Antonino Coppola, Domenico De Lucia, and Angelo Tirelli. "C1 Inhibitor Infusion Modifies Platelet Activity in Hereditary Angioedema Patients." Archives of Pathology & Laboratory Medicine 126, no. 7 (2002): 842–45. http://dx.doi.org/10.5858/2002-126-0842-ciimpa.

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Abstract Context.—C1 inhibitor (C1-INH) is an α2-globulin that blocks esterolytic activity of the first component of the classic complement cascade. The α-granules of normal human platelets also contain C1-INH, which is expressed on the platelet surface during platelet secretion in healthy patients, but it is clearly reduced in patients with hereditary angioedema (HAE). Objective.—To evaluate the effects of in vivo C1-INH concentrate infusion on platelet responsiveness and coagulation system activity in patients with HAE. Design.—Assessment of the platelet activity and plasma levels of C1-INH,

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I, Anu R., Aastha Vatsyayan, Ambily Sivadas, Dileep Damodaran, and Kurt van der Speeten. "Abstract 1154: Multi-omic analysis classifies colorectal cancer into distinct angiogenic and immunogenic subtypes based on anatomical laterality." Cancer Research 82, no. 12_Supplement (2022): 1154. http://dx.doi.org/10.1158/1538-7445.am2022-1154.

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Abstract Background: Colorectal cancer is a heterogeneous disease of tumors from distinct anatomical and embryological sources. According to GLOBOCAN2020, it is the second leading cause of cancer-related mortality1. Methodology: Utilising NIH-GDC2 datasets, we applied Bioinformatic algorithms to categorize LCRC and RCRC based on multi-omic variables. Mutational analysis was done using STRING v11.53. Kaplan-Meier were plotted. Transcriptome data was accessed using Bioconductor4 package TCGABiolinks5 and annotated as ‘Left’ or ‘Right’ based on tissue of origin. DE analysis was performed using DE

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Viel, Kevin R., Benjamin Kim, Maria Elizabeth Tejero, Shelley S. Cole, Tom E. Howard, and Amparo Santamaría Ortiz. "The Spectrum of Amino Acid Substitutions Resulting from Single Nucleotide Substitutions in the Coagulation Biosystem: Impact on Identification By Mass Spectrometry." Blood 124, no. 21 (2014): 4221. http://dx.doi.org/10.1182/blood.v124.21.4221.4221.

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Abstract INTRODUCTION Mass spectrometry (MS) is a potentially useful tool for the study of the hemostasic system and its imbalances that lead to bleeding and thrombotic disorders. By harnessing the high throughput and broad scope of MS, vast data may be available to investigators and clinicians to help predict or manage hemostatic events. Although utilizing MS to evaluate coagulation proteins appears promising, amino acid (AA) substitutions resulting from genetic variation may yield a spectrum of mass-to-charge ratios (m/z) that can impede accurate protein identification. The goals of this stu

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Adamiak, Mateusz, Andrzej Ciechanowicz, Monika Cymer, Marta Skoda, and Mariusz Z. Ratajczak. "Nlrp3 Inflammasome Activation in Bone Marrow-Residing Innate Immunity Cells Governs Circadian Changes in the Number of Circulating Hematopoietic Stem/Progenitor Cells in Peripheral Blood." Blood 134, Supplement_1 (2019): 1033. http://dx.doi.org/10.1182/blood-2019-125853.

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Background. The number of hematopoietic stem/progenitor cells (HSPCs) in peripheral blood (PB) undergoes a circadian oscillation, with the peak occurring in the early morning hours and the nadir at night, and, as nicely demonstrated, this peak has been attributed to the enhanced tonus of the vegetative nervous system in the early morning hours (Nature 2008, 452, 442-447). Moreover, our group has demonstrated that release of HSPCs from bone marrow (BM) into PB is regulated during stress- or pharmacology-induced mobilization by activation of three ancient serum proteolytic cascades, the compleme

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Meroni, Pier Luigi, Claudia Grossi, and Francesco Tedesco. "Pathogenesis of the obstetric antiphospholipid syndrome: the key role of beta 2 glycoprotein I." Exploration of Immunology, August 19, 2022, 510–17. http://dx.doi.org/10.37349/ei.2022.00064.

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Antiphospholipid syndrome (APS) is defined by recurrent pregnancy morbidity and/or vascular thrombosis associated with the persistent presence of antibodies against anionic phospholipid-binding proteins. Beta 2 glycoprotein I (β2GPI) and prothrombin (PT) are the major antigens for antiphospholipid antibodies (aPL) detectable by functional coagulation [lupus anticoagulant (LA)] or solid-phase assays [anti-β2GPI-dependent cardiolipin (aCL) and anti-β2GPI]. β2GPI-dependent aPL are responsible for the positivity of the three classification laboratory criteria. While medium/high titers of antibodie

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Wong, Phing Sue, Thomas Rhys, Mangat Pamela, Beynon Huw, and Richard Stratton. "P02 Doctor, I just don't feel alright." Rheumatology Advances in Practice 5, Supplement_1 (2021). http://dx.doi.org/10.1093/rap/rkab068.001.

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Abstract Case report - Introduction Antiphospholipid syndrome (APS), also known as Hughes syndrome, was first reported by Dr. Graham Hughes in 1983. It can be primary or secondary, with the latter associated with underlying rheumatological conditions. APS is an immune-mediated disorder with the hallmark of pregnancy morbidity and vascular thrombotic events associated with persistent antiphospholipid antibodies (aPLs). Rarely it causes catastrophic APS or Asherson syndrome. Neurological manifestation of APS is not uncommon. It can affect central, peripheral as well as autonomic neural system th

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Burmeister, Antonia, Sabine Vidal-y-Sy, Xiaobo Liu, et al. "Impact of neutrophil extracellular traps on fluid properties, blood flow and complement activation." Frontiers in Immunology 13 (December 16, 2022). http://dx.doi.org/10.3389/fimmu.2022.1078891.

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IntroductionThe intravascular formation of neutrophil extracellular traps (NETs) is a trigger for coagulation and blood vessel occlusion. NETs are released from neutrophils as a response to strong inflammatory signals in the course of different diseases such as COVID-19, cancer or antiphospholipid syndrome. NETs are composed of large, chromosomal DNA fibers decorated with a variety of proteins such as histones. Previous research suggested a close mechanistic crosstalk between NETs and the coagulation system involving the coagulation factor XII (FXII), von Willebrand factor (VWF) and tissue fac

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Yu, Liang, Huaji Shen, Xiaohan Ren, et al. "Multi‐omics analysis reveals the interaction between the complement system and the coagulation cascade in the development of endometriosis." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-90112-x.

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AbstractEndometriosis (EMS) is a disease that shows immune dysfunction and chronic inflammation characteristics, suggesting a role of complement system in its pathophysiology. To find out the hub genes and pathways involved in the pathogenesis of EMs, three raw microarray datasets were recruited from the Gene Expression Omnibus database (GEO). Then, a series of bioinformatics technologies including gene ontology (GO), Hallmark pathway enrichment, protein–protein interaction (PPI) network and gene co-expression correlation analysis were performed to identify hub genes. The hub genes were furthe

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Gavriilaki, Eleni, Vincent T. Ho, Wilhelm Schwaeble, et al. "Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy." Experimental Hematology & Oncology 10, no. 1 (2021). http://dx.doi.org/10.1186/s40164-021-00249-8.

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AbstractHematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric patients after hematopoietic stem cell transplantation. Nonspecific symptoms, heterogeneity within study populations, and variability among current diagnostic criteria contribute to misdiagnosis and underdiagnosis of this syndrome. Hematopoietic stem cell transplantation and associated risk factors precipitate endothelial injury, leading to HSCT-TMA and other endothelial injury syndromes such as hepatic veno-occlusive disease/sinusoi

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Rydbirk, Rasmus, Ole Østergaard, Jonas Folke, et al. "Brain proteome profiling implicates the complement and coagulation cascade in multiple system atrophy brain pathology." Cellular and Molecular Life Sciences 79, no. 6 (2022). http://dx.doi.org/10.1007/s00018-022-04378-z.

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Grossi, Claudia, Nagaja Capitani, Marisa Benagiano, et al. "Beta 2 glycoprotein I and neutrophil extracellular traps: Potential bridge between innate and adaptive immunity in anti-phospholipid syndrome." Frontiers in Immunology 13 (January 9, 2023). http://dx.doi.org/10.3389/fimmu.2022.1076167.

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Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent vascular thrombosis and miscarriages in the absence of known causes. Antibodies against phospholipid-binding proteins (aPL) are pathogenic players in both clotting and pregnancy APS manifestations. There is sound evidence that antibodies specific for beta2 glycoprotein I (β2GPI) trigger thrombotic and pregnancy complications by interacting with the molecule on the membranes of different cell types of the coagulation cascade, and in placenta tissues. In addition to the humoral response against β2GPI, bo

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Moraes, Daniela, Camila Milioni, Carolina Friske Vieira, et al. "Immature Platelet Fraction and Thrombin Generation: Preeclampsia Biomarkers." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics, July 11, 2022. http://dx.doi.org/10.1055/s-0042-1743100.

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AbstractPreeclampsia, a human pregnancy syndrome, is characterized by elevated blood pressure and proteinuria after the 20th week of gestation. Its etiology remains unknown, and its pathophysiological mechanisms are related to placental hypoperfusion, endothelial dysfunction, inflammation, and coagulation cascade activation. Recently, the role of the complement system has been considered. This syndrome is one of the main causes of maternal and fetal mortality and morbidity. This article discusses the hypothesis of preeclampsia being triggered by the occurrence of inadequate implantation of the

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van Erp, Inge A. M., Iliana Michailidou, Thomas A. van Essen, et al. "Tackling Neuroinflammation After Traumatic Brain Injury: Complement Inhibition as a Therapy for Secondary Injury." Neurotherapeutics, October 12, 2022. http://dx.doi.org/10.1007/s13311-022-01306-8.

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AbstractTraumatic brain injury (TBI) is a leading cause of mortality, sensorimotor morbidity, and neurocognitive disability. Neuroinflammation is one of the key drivers causing secondary brain injury after TBI. Therefore, attenuation of the inflammatory response is a potential therapeutic goal. This review summarizes the most important neuroinflammatory pathophysiology resulting from TBI and the clinical trials performed to attenuate neuroinflammation. Studies show that non-selective attenuation of the inflammatory response, in the early phase after TBI, might be detrimental and that there is

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Lipcsey, Miklós, Barbro Persson, Oskar Eriksson, et al. "The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System." Frontiers in Immunology 12 (February 22, 2021). http://dx.doi.org/10.3389/fimmu.2021.627579.

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An important manifestation of severe COVID-19 is the ARDS-like lung injury that is associated with vascular endothelialitis, thrombosis, and angiogenesis. The intravascular innate immune system (IIIS), including the complement, contact, coagulation, and fibrinolysis systems, which is crucial for recognizing and eliminating microorganisms and debris in the body, is likely to be involved in the pathogenesis of COVID-19 ARDS. Biomarkers for IIIS activation were studied in the first 66 patients with COVID-19 admitted to the ICU in Uppsala University Hospital, both cross-sectionally on day 1 and in

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Malik, Astha, Unmesha Thanekar, Surya Amarachintha, et al. "“Complimenting the Complement”: Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma." Frontiers in Oncology 10 (February 24, 2021). http://dx.doi.org/10.3389/fonc.2020.627701.

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Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and a leading cause of death in the US and worldwide. HCC remains a global health problem and is highly aggressive with unfavorable prognosis. Even with surgical interventions and newer medical treatment regimens, patients with HCC have poor survival rates. These limited therapeutic strategies and mechanistic understandings of HCC immunopathogenesis urgently warrant non-palliative treatment measures. Irrespective of the multitude etiologies, the liver microenvironment in HCC is intricately associated with chronic

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