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Journal articles on the topic 'APSoC'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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1

Hsieh, Jui-Hung, Jun-An Cai, Yi-Ning Wang, and Zhe-Yu Guo. "ML-Assisted DVFS-Aware HEVC Motion Estimation Design Scheme for Mobile APSoC." IEEE Systems Journal 13, no. 4 (December 2019): 4464–73. http://dx.doi.org/10.1109/jsyst.2018.2885538.

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2

Meloni, Paolo, Daniela Loi, Gianfranco Deriu, Marco Carreras, Francesco Conti, Alessandro Capotondi, and Davide Rossi. "Exploring NEURAghe: A Customizable Template for APSoC-Based CNN Inference at the Edge." IEEE Embedded Systems Letters 12, no. 2 (June 2020): 62–65. http://dx.doi.org/10.1109/les.2019.2947312.

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3

Leone, Gianluca, Luigi Raffo, and Paolo Meloni. "ZyON: Enabling Spike Sorting on APSoC-Based Signal Processors for High-Density Microelectrode Arrays." IEEE Access 8 (2020): 218145–60. http://dx.doi.org/10.1109/access.2020.3042034.

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4

Sun, Yue, Pan-feng Wu, Jie Li, and Zong-feng Ma. "RETRACTED ARTICLE: Research on Dual-Core Lock Step Mechanism and Its Application for Commercial High Performance APSoC." Advances in Astronautics Science and Technology 2, no. 1-2 (June 5, 2019): 43. http://dx.doi.org/10.1007/s42423-019-00036-y.

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5

Tambara, L. A., E. Chielle, F. L. Kastensmidt, G. Tsiligiannis, S. Danzeca, M. Brugger, and A. Masi. "Analyzing the impact of radiation-induced failures in flash-based APSoC with and without fault tolerance techniques at CERN environment." Microelectronics Reliability 76-77 (September 2017): 640–43. http://dx.doi.org/10.1016/j.microrel.2017.06.049.

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6

Vasudevan, Jayanand, John E. Humphries, and Steven L. Gonias. "Binding of Anisoylated Lys-Plasminogen Streptokinase Activator Complex to Cells in Culture." Thrombosis and Haemostasis 69, no. 04 (1993): 370–74. http://dx.doi.org/10.1055/s-0038-1651614.

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SummaryAnisoylated Lys-plasminogen streptokinase activator complex (APSAC) was purified from Eminase® by chromatography on Superose-12. Purified APSAC did not significantly deacylate within 4 h at 4° C in solution as determined by hydrolysis of D-Val-L-leu-L-lys-p-nitroanilide HCl (S-2251). At 37° C, maximum amidase activity developed in 120 min; ε-amino-n-caproic acid (EACA) did not affect the apparent rate of APSAC deacylation but stabilized the streptokinase-plasmin(ogen) complex (SkPl) which formed. APSAC bound to C6 glioma cells and human umbilical vein endothelial cells (HUVECs) in culture. Binding was completely inhibited by EACA suggesting an essential role for the plasminogen kringle domains. Cell-associated APSAC deacylated to form active SkPl which hydrolyzed S-2251 and D-Val-Leu-Lys-7-amino-4-methyl coumarin. The rate of APSAC deacylation was increased when the APSAC was cell-associated. APSAC that was initially bound to C6 cells or HUVECs also activated 125I-plasminogen. This activity may have reflected cell-associated APSAC or APSAC that dissociated into solution. Plasmin was recovered bound to cells and in solution. These studies demonstrate that APSAC associates with cell-surfaces and retains activity. In the circulation, cell-surfaces may provide a significant pharmacologic compartment for intravenously administered APSAC.
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7

Olivieri, Oliviero, Carmela Chiariello, Nicola Martinelli, Annalisa Castagna, Giulia Speziali, Domenico Girelli, Francesca Pizzolo, et al. "Sialylated isoforms of apolipoprotein C-III and plasma lipids in subjects with coronary artery disease." Clinical Chemistry and Laboratory Medicine (CCLM) 56, no. 9 (August 28, 2018): 1542–50. http://dx.doi.org/10.1515/cclm-2017-1099.

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AbstractBackground:Apolipoprotein C-III (ApoC-III), a key regulator of plasma triglyceride (TG), is present in three isoforms, i.e. non-sialylated (ApoC-III0), monosialylated (ApoC-III1) and disialylated (ApoC-III2). We aimed at quantifying the distribution of the ApoC-III glycoforms in patients with angiographically demonstrated coronary artery disease (CAD) according to levels of total ApoC-III plasma concentration.Methods:ApoC-III glycoforms were quantified by a specifically developed, high-resolution, mass spectrometry method in unrelated CAD patients. Lipoprotein lipase (LPL) activity was estimated by a fluorescence-based method.Results:In 101 statin-treated CAD patients, the absolute concentrations of the three glycoforms similarly increased across ApoC-III quartiles, but the proportion of ApoC-III1 rose whereas that of ApoC-III0 decreased progressively by increasing total ApoC-III concentrations. The proportion of ApoC-III2 was quite constant throughout the whole range of total ApoC-III. A higher proportion of ApoC-III1 reflected an unfavorable lipid profile characterized by high levels of TG, total and low density lipoprotein cholesterol, ApoE and reduced ApoA-I. The correlations between ApoC-III glycoforms and TG were confirmed in 50 statin-free CAD patients. High concentration of total ApoC-III was associated with low LPL activity, while no correlation was found for the relative proportion of glycoforms.Conclusions:Specific patterns of ApoC-III glycoforms are present across different total ApoC-III concentrations in CAD patients. The inhibitory effect of ApoC-III on LPL appears related to total ApoC-III concentration, but not to the relative proportion of ApoC-III glycoforms.
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8

Kegulian, Natalie C., Bastian Ramms, Steven Horton, Olgica Trenchevska, Dobrin Nedelkov, Mark J. Graham, Richard G. Lee, Jeffrey D. Esko, Hussein N. Yassine, and Philip L. S. M. Gordts. "ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors." Arteriosclerosis, Thrombosis, and Vascular Biology 39, no. 10 (October 2019): 2145–56. http://dx.doi.org/10.1161/atvbaha.119.312723.

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Objective: ApoC-III (apolipoprotein C-III) glycosylation can predict cardiovascular disease risk. Higher abundance of disialylated (apoC-III 2 ) over monosialylated (apoC-III 1 ) glycoforms is associated with lower plasma triglyceride levels. Yet, it remains unclear whether apoC-III glycosylation impacts TRL (triglyceride-rich lipoprotein) clearance and whether apoC-III antisense therapy (volanesorsen) affects distribution of apoC-III glycoforms. Approach and Results: To measure the abundance of human apoC-III glycoforms in plasma over time, human TRLs were injected into wild-type mice and mice lacking hepatic TRL clearance receptors, namely HSPGs (heparan sulfate proteoglycans) or both LDLR (low-density lipoprotein receptor) and LRP1 (LDLR-related protein 1). ApoC-III was more rapidly cleared in the absence of HSPG (t 1/2 =25.4 minutes) than in wild-type animals (t 1/2 =55.1 minutes). In contrast, deficiency of LDLR and LRP1 (t 1/2 =56.1 minutes) did not affect clearance of apoC-III. After injection, a significant increase in the relative abundance of apoC-III 2 was observed in HSPG-deficient mice, whereas the opposite was observed in mice lacking LDLR and LRP1. In patients, abundance of plasma apoC-III glycoforms was assessed after placebo or volanesorsen administration. Volanesorsen treatment correlated with a statistically significant 1.4-fold increase in the relative abundance of apoC-III 2 and a 15% decrease in that of apoC-III 1 . The decrease in relative apoC-III 1 abundance was strongly correlated with decreased plasma triglyceride levels in patients. Conclusions: Our results indicate that HSPGs preferentially clear apoC-III 2 . In contrast, apoC-III 1 is more effectively cleared by LDLR/LRP1. Clinically, the increase in the apoC-III 2 /apoC-III 1 ratio on antisense lowering of apoC-III might reflect faster clearance of apoC-III 1 because this metabolic shift associates with improved triglyceride levels.
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9

Chen, Fei, Ying Juan Yue, Wen Xia Sun, and Ya Que Jing. "Study on the Ultraviolet Aging of APMOC Fiber." Applied Mechanics and Materials 331 (July 2013): 396–99. http://dx.doi.org/10.4028/www.scientific.net/amm.331.396.

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An ultraviolet aging test of APMOC fiber is carried out with the irradiation of xenon lamp, in which the effects of ultraviolet aging on APMOC fiber were studied by single fiber tension and FTIR. The result shows that the tensile strength, the modulus of elasticity and the elongation rate of APMOC fiber would have a change, among which the tensile strength increases by 13.7% after 6 hours UV irradiation and decreases by 2.1% after 36 hours. The C-N in amide of the APMOC fiber is broken; while the hydrogen bond combination ability and crystallinity increase by FTIR. It can, therefore, be concluded that short time UV irradiation can cause two contradictory effects on APMOC fiber.
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10

Saito, Shigeru. "APSIC: Its future." Catheterization and Cardiovascular Interventions 74, no. 2 (July 29, 2009): 373–74. http://dx.doi.org/10.1002/ccd.22135.

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11

Nasution, Husni, Shinta Rahma Diana, Bernhard Sianipar, Sri Rubiyanti, Dini Susanti, and Astri Rafikasari. "Indonesia Membership on Asia-Pacific Space Cooperation Organization (APSCO): Cost and Benefit Analysis." Jurnal Hubungan Internasional 11, no. 1 (November 1, 2018): 121. http://dx.doi.org/10.20473/jhi.v11i1.6429.

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Indonesia with seven other countries, namely Bangladesh, China, Iran, Mongolia, Pakistan, Peru, and Thailand are the signatory countries of APSCO Convention, on October 28th, 2005. APSCO is space coopeation organization outside the United Nations system for the Asia Pacific region, initiated by the People’s Republic of China. To date, from the eight signatory countries, only Indonesia has not ratified yet and has not become a full member of APSCO. This paper examines cost and benefit of the Indonesia membership on APSCO. The methods used are quantitative and qualitative method. While the analysis used approaches related to contribution of cost to provided and benefits to be received by Indonesia as well as the national interest mentioned in Presidential Decree No. 64/1999 on Indonesian Membership and Indonesian Government Contributions to International Organizations. From the study, it was found that by ratifying the Convention and following APSCO activities optimally, the benefits will be receive by Indonesia greater than contribution given to APSCO. Similarry, the joining of Indonesia in APSCO will also provide substansial benefit for the national interest, especially for politic, economic, international peace and security, humanity, and others as well as enhancing better relationship among countries in the Asia-Pacific region.
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12

Montazeri, Hesam, Mairene Coto-Llerena, Gaia Bianco, Ehsan Zangene, Stephanie Taha-Mehlitz, Viola Paradiso, Sumana Srivatsa, et al. "Systematic identification of novel cancer genes through analysis of deep shRNA perturbation screens." Nucleic Acids Research 49, no. 15 (July 27, 2021): 8488–504. http://dx.doi.org/10.1093/nar/gkab627.

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Abstract Systematic perturbation screens provide comprehensive resources for the elucidation of cancer driver genes. The perturbation of many genes in relatively few cell lines in such functional screens necessitates the development of specialized computational tools with sufficient statistical power. Here we developed APSiC (Analysis of Perturbation Screens for identifying novel Cancer genes) to identify genetic drivers and effectors in perturbation screens even with few samples. Applying APSiC to the shRNA screen Project DRIVE, APSiC identified well-known and novel putative mutational and amplified cancer genes across all cancer types and in specific cancer types. Additionally, APSiC discovered tumor-promoting and tumor-suppressive effectors, respectively, for individual cancer types, including genes involved in cell cycle control, Wnt/β-catenin and hippo signalling pathways. We functionally demonstrated that LRRC4B, a putative novel tumor-suppressive effector, suppresses proliferation by delaying cell cycle and modulates apoptosis in breast cancer. We demonstrate APSiC is a robust statistical framework for discovery of novel cancer genes through analysis of large-scale perturbation screens. The analysis of DRIVE using APSiC is provided as a web portal and represents a valuable resource for the discovery of novel cancer genes.
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13

Batista, J., V. Kaucic, and S. Hocevar. "On the Formation of AlPO4-Based Molecular-Sieves in the Presence of Cyclohexylamine." Australian Journal of Chemistry 46, no. 2 (1993): 171. http://dx.doi.org/10.1071/ch9930171.

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The hydrothermal synthesis of the AlPO4-17, SAPO-44, MnAPSO-44 and intermediate solid phases [samples (APO)N, (APSO)N and Mn (APSO)N] in the presence of cyclohexylamine (cha) is described. (APO)N, (APSO)N and Mn (APSO)N represent unknown, layer-type, crystalline phases with different chemical compositions. These phases are predominantly formed at a high cha concentration and low crystallization temperature. All synthesized materials contain protonated cha in their structure, but only in AlPO4-17, (APO)N,(APSO)N and Mn (APSO)N is the -OH group also found. The calcination of the unknown phases leads to the loss of crystallinity and causes a complete breakdown of the crystal structure above 270°C.
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14

Binette, Mark J. "Failure of APSAC Thrombolysis." Annals of Internal Medicine 119, no. 7_Part_1 (October 1, 1993): 637. http://dx.doi.org/10.7326/0003-4819-119-7_part_1-199310010-00028.

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15

Park, Seung-Jung. "APSIC, ready to jump!" Catheterization and Cardiovascular Interventions 74, no. 1 (July 1, 2009): 151–52. http://dx.doi.org/10.1002/ccd.22134.

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16

KARDASSIS, Dimitris, Anastasia ROUSSOU, Paraskevi PAPAKOSTA, Konstantinos BOULIAS, Iannis TALIANIDIS, and Vassilis I. ZANNIS. "Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids." Biochemical Journal 372, no. 2 (June 1, 2003): 291–304. http://dx.doi.org/10.1042/bj20021532.

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We have shown previously that the hepatic control region 1 (HCR-1) enhances the activity of the human apolipoprotein C-II (apoC-II) promoter in HepG2 cells via two hormone response elements (HREs) present in the apoC-II promoter. In the present paper, we report that the HCR-1 selectively mediates the transactivation of the apoC-II promoter by chenodeoxycholic acid (CDCA) and 9-cis-retinoic acid. CDCA, which is a natural ligand of farnesoid X receptor α (FXRα), increases the steady-state apoC-II mRNA levels in HepG2 cells. This increase in transcription requires the binding of retinoid X receptor α (RXRα)–FXRα heterodimers to a novel inverted repeat with one nucleotide spacing (IR-1) present in the HCR-1. This element also binds hepatocyte nuclear factor 4 and apoA-I regulatory protein-1. Transactivation of the HCR-1/apoC-II promoter cluster by RXRα–FXRα heterodimers in the presence of CDCA was abolished by mutations either in the IR-1 HRE of the HCR-1 or in the thyroid HRE of the proximal apoC-II promoter, which binds RXRα–thyroid hormone receptor β (T3Rβ) heterodimers. The same mutations also abolished transactivation of the HCR-1/apoC-II promoter cluster by RXRα–T3Rβ heterodimers in the presence of tri-iodothyronine. The findings establish synergism between nuclear receptors bound to specific HREs of the proximal apoC-II promoter and the HCR-1, and suggest that this synergism mediates the induction of the HCR-1/apoC-II promoter cluster by bile acids and retinoids.
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17

Scheffer, Peter G., Tom Teerlink, Jacqueline M. Dekker, Griët Bos, Giel Nijpels, Michaela Diamant, Piet J. Kostense, Coen D. A. Stehouwer, and Robert J. Heine. "Increased Plasma Apolipoprotein C-III Concentration Independently Predicts Cardiovascular Mortality: The Hoorn Study." Clinical Chemistry 54, no. 8 (August 1, 2008): 1325–30. http://dx.doi.org/10.1373/clinchem.2008.103234.

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Abstract Background: Hypertriglyceridemia is a cardiovascular risk factor. Apolipoprotein C-III (apoC-III) is an important determinant of the catabolic rate of triglyceride-rich lipoproteins. The aim of this study was to investigate the prognostic value of plasma apoC-III concentrations for cardiovascular mortality. Methods: We performed this prospective study in 2244 subjects (ages 49–77 years) who participated in the Hoorn Study. During a mean follow-up of 15 years, 504 individuals died: 231 of cardiovascular disease, 180 of cancer, and 93 of other causes. Cardiovascular disease risk factors and plasma apoC-III concentrations were measured at baseline. Results: The age- and sex-adjusted plasma apoC-III concentration was prospectively associated with cardiovascular mortality (P < 0.001). After adjustment for traditional risk factors, including fasting triglycerides, the hazard ratio (95% CI) for cardiovascular death between the highest and the lowest quartile of apoC-III was 1.85 (1.02–3.38). High concentrations of apoC-III did not appear to be associated with noncardiovascular mortality. Conclusions: In this general population cohort, a high apoC-III concentration in plasma, independently of fasting triglycerides and other traditional risk factors, predicts cardiovascular mortality.
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Kotite, L., L.-H. Zhang, Z. Yu, A. L. Burlingame, and R. J. Havel. "Human apoC-IV." Journal of Lipid Research 44, no. 7 (April 16, 2003): 1387–94. http://dx.doi.org/10.1194/jlr.m300087-jlr200.

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19

Huynh, Karina. "Dual apoC-II mimetic and apoC-III antagonist for hypertriglyceridaemia." Nature Reviews Cardiology 17, no. 4 (February 13, 2020): 201. http://dx.doi.org/10.1038/s41569-020-0351-6.

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20

Chen, Fei, Ying Juan Yue, Wen Xia Sun, and Hai Xia Du. "Effects on the Structures and Properties of APMOC Fiber from Hydrothermal Aging." Advanced Materials Research 744 (August 2013): 288–92. http://dx.doi.org/10.4028/www.scientific.net/amr.744.288.

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By the test of hydrothermal aging, the effect on the structures and properties of APMOC fiber is studied, while monofilament tensile test and the corresponding structural analysis are carried out on the test samples. The results show that, in the range of experimental temperature and humidity, APMOC had no significant change in molecular structure; after hydrothermal aging, the tensile strength, elongation and elastic modulus of APMOC fiber show some fluctuation, instead of downward trend continually, there are more obvious effects on the changes of the tensile strength from temperature, i.e. the higher the temperature, the lower the tensile strength during the process of aging. The general effect of thermal aging on fiber properties are the embrittlement and the decreased elongation. The microscopic mechanism of fiber failure modes from raw fiber splitting to brittle rupture is interpreted through the scanning electron microscopy (SEM) observation on the tensile fracture before and after aging, combined with the skin core structure characteristics of APMOC fiber.
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21

Ooi, Esther M. M., P. Hugh R. Barrett, Dick C. Chan, and Gerald F. Watts. "Apolipoprotein C-III: understanding an emerging cardiovascular risk factor." Clinical Science 114, no. 10 (April 14, 2008): 611–24. http://dx.doi.org/10.1042/cs20070308.

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The concurrence of visceral obesity, insulin resistance and dyslipidaemia comprises the concept of the metabolic syndrome. The metabolic syndrome is an escalating problem in developed and developing societies that tracks with the obesity epidemic. Dyslipidaemia in the metabolic syndrome is potently atherogenic and, hence, is a major risk factor for CVD (cardiovascular disease) in these subjects. It is globally characterized by hypertriglyceridaemia, near normal LDL (low-density lipoprotein)-cholesterol and low plasma HDL (high-density lipoprotein)-cholesterol. ApoC-III (apolipoprotein C-III), an important regulator of lipoprotein metabolism, is strongly associated with hypertriglyceridaemia and the progression of CVD. ApoC-III impairs the lipolysis of TRLs [triacylglycerol (triglyceride)-rich lipoproteins] by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. In the circulation, apoC-III is associated with TRLs and HDL, and freely exchanges among these lipoprotein particle systems. However, to fully understand the complex physiology and pathophysiology requires the application of tracer methodology and mathematical modelling. In addition, experimental evidence shows that apoC-III may also have a direct role in atherosclerosis. In the metabolic syndrome, increased apoC-III concentration, resulting from hepatic overproduction of VLDL (very-LDL) apoC-III, is strongly associated with delayed catabolism of triacylglycerols and TRLs. Several therapies pertinent to the metabolic syndrome, such as PPAR (peroxisome-proliferator-activated receptor) agonists and statins, can regulate apoC-III transport in the metabolic syndrome. Regulating apoC-III metabolism may be an important new therapeutic approach to managing dyslipidaemia and CVD risk in the metabolic syndrome.
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22

Hansen, John-Bjarne, José A. Fernández, Ann-Trude With Notø, Hiroshi Deguchi, Johan Björkegren, and Ellisiv B. Mathiesen. "The Apolipoprotein C-I Content of Very-Low-Density Lipoproteins Is Associated with Fasting Triglycerides, Postprandial Lipemia, and Carotid Atherosclerosis." Journal of Lipids 2011 (2011): 1–9. http://dx.doi.org/10.1155/2011/271062.

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Background. Experimental studies in animals suggest that apolipoprotein (apo) C-I is an important regulator of triglycerides in fasting and postprandial conditions and associated with carotid atherosclerosis.Methods. A cross-sectional study was conducted with 81 subjects, aged 56–80 years recruited from a population health survey. The participants underwent a fat tolerance test (1 g fat per Kg body weight) and carotid atherosclerosis was determined by ultrasound examination. VLDL particles, Sf 20–400, were isolated and their lipid composition and apoC-I content determined.Results. The carotid plaque area increased linearly with the number of apoC-I molecules per VLDL particles (P=0.048) under fasting conditions. Fasting triglycerides increased across tertiles of apoC-I per VLDL particle in analyses adjusted for apoC-II and -C-III, apoE genotype and traditional cardiovascular risk factors (P=0.011). The relation between apoC-I in VLDL and serum triglycerides was conveyed by triglyceride enrichment of VLDL particles (Pfor trend <0.001. The amount of apoC-I molecules per VLDL was correlated with the total (r=0.41,P<0.0001) and incremental (r=0.35,P<0.001) area under the postprandial triglyceride curve.Conclusions. Our findings support the concept that the content of apoC-I per VLDL particle is an important regulator of triglyceride metabolism in the fasting and postprandial state and associated with carotid athrosclerosis.
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23

Lau, Darryl, Alexander F. Haddad, Vedat Deviren, and Christopher P. Ames. "Asymmetrical pedicle subtraction osteotomy for correction of concurrent sagittal-coronal imbalance in adult spinal deformity: a comparative analysis." Journal of Neurosurgery: Spine 33, no. 6 (December 2020): 822–29. http://dx.doi.org/10.3171/2020.5.spine20445.

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OBJECTIVERigid multiplanar thoracolumbar adult spinal deformity (ASD) cases are challenging and many require a 3-column osteotomy (3CO), specifically asymmetrical pedicle subtraction osteotomy (APSO). The outcomes and additional risks of performing APSO for the correction of concurrent sagittal-coronal deformity have yet to be adequately studied.METHODSThe authors performed a retrospective review of all ASD patients who underwent 3CO during the period from 2006 to 2019. All cases involved either isolated sagittal deformity (patients underwent standard PSO) or concurrent sagittal-coronal deformity (coronal vertical axis [CVA] ≥ 4.0 cm; patients underwent APSO). Perioperative and 2-year follow-up outcomes were compared between patients with isolated sagittal imbalance who underwent PSO and those with concurrent sagittal-coronal imbalance who underwent APSO.RESULTSA total of 390 patients were included: 338 who underwent PSO and 52 who underwent APSO. The mean patient age was 64.6 years, and 65.1% of patients were female. APSO patients required significantly more fusions with upper instrumented vertebrae (UIV) in the upper thoracic spine (63.5% vs 43.3%, p = 0.007). Radiographically, APSO patients had greater deformity with more severe preoperative sagittal and coronal imbalance: sagittal vertical axis (SVA) 13.0 versus 10.7 cm (p = 0.042) and CVA 6.1 versus 1.2 cm (p < 0.001). In APSO cases, significant correction and normalization were achieved (SVA 13.0–3.1 cm, CVA 6.1–2.0 cm, lumbar lordosis [LL] 26.3°–49.4°, pelvic tilt [PT] 38.0°–20.4°, and scoliosis 25.0°–10.4°, p < 0.001). The overall perioperative complication rate was 34.9%. There were no significant differences between PSO and APSO patients in rates of complications (overall 33.7% vs 42.3%, p = 0.227; neurological 5.9% vs 3.9%, p = 0.547; medical 20.7% vs 25.0%, p = 0.482; and surgical 6.5% vs 11.5%, p = 0.191, respectively). However, the APSO group required significantly longer stays in the ICU (3.1 vs 2.3 days, p = 0.047) and hospital (10.8 vs 8.3 days, p = 0.002). At the 2-year follow-up, there were no significant differences in mechanical complications, including proximal junctional kyphosis (p = 0.352), pseudarthrosis (p = 0.980), rod fracture (p = 0.852), and reoperation (p = 0.600).CONCLUSIONSASD patients with significant coronal imbalance often have severe concurrent sagittal deformity. APSO is a powerful and effective technique to achieve multiplanar correction without higher risk of morbidity and complications compared with PSO for sagittal imbalance. However, APSO is associated with slightly longer ICU and hospital stays.
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Wolska, Anna, Larry Lo, Denis O. Sviridov, Mohsen Pourmousa, Milton Pryor, Soumitra S. Ghosh, Rahul Kakkar, et al. "A dual apolipoprotein C-II mimetic–apolipoprotein C-III antagonist peptide lowers plasma triglycerides." Science Translational Medicine 12, no. 528 (January 29, 2020): eaaw7905. http://dx.doi.org/10.1126/scitranslmed.aaw7905.

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Recent genetic studies have established that hypertriglyceridemia (HTG) is causally related to cardiovascular disease, making it an active area for drug development. We describe a strategy for lowering triglycerides (TGs) with an apolipoprotein C-II (apoC-II) mimetic peptide called D6PV that activates lipoprotein lipase (LPL), the main plasma TG-hydrolyzing enzyme, and antagonizes the TG-raising effect of apoC-III. The design of D6PV was motivated by a combination of all-atom molecular dynamics simulation of apoC-II on the Anton 2 supercomputer, structural prediction programs, and biophysical techniques. Efficacy of D6PV was assessed ex vivo in human HTG plasma and was found to be more potent than full-length apoC-II in activating LPL. D6PV markedly lowered TG by more than 80% within a few hours in both apoC-II–deficient mice and hAPOC3-transgenic (Tg) mice. In hAPOC3-Tg mice, D6PV treatment reduced plasma apoC-III by 80% and apoB by 65%. Furthermore, low-density lipoprotein (LDL) cholesterol did not accumulate but rather was decreased by 10% when hAPOC3-Tg mice lacking the LDL-receptor (hAPOC3-Tg × Ldlr−/−) were treated with the peptide. D6PV lowered TG by 50% in whole-body inducible Lpl knockout (iLpl−/−) mice, confirming that it can also act independently of LPL. D6PV displayed good subcutaneous bioavailability of about 80% in nonhuman primates. Because it binds to high-density lipoproteins, which serve as a long-term reservoir, it also has an extended terminal half-life (42 to 50 hours) in nonhuman primates. In summary, D6PV decreases plasma TG by acting as a dual apoC-II mimetic and apoC-III antagonist, thereby demonstrating its potential as a treatment for HTG.
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Jacob Olufemi, Fatile,, Mutereko Sybert, and Emma Etim. "Process Reengineering in African Public Sector: Lessons From the Private Sector." Journal of Public Administration and Governance 10, no. 3 (September 14, 2020): 262. http://dx.doi.org/10.5296/jpag.v10i3.17688.

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Process reengineering (PR) is a newly introduced approach to process management; it pays close attention to all the processes that are related to the achievement of organizational objectives. Although originally developed for and applied in the private sector, PR is expected to constitute a handy tool for the transformation of work processes in public sector organizations (PSOs), especially in this era of information and communications technology. This paper x-rays PR in African public sector organizations (APSOs) with an emphasis on lessons to be learnt from the private sector. This paper adopts a descriptive approach, to validate and modify extant theoretical models that are relevant in explaining PR in APSOs. The paper observes that APSOs, unlike the private sector organizations (PrSOs), PSOs have failed in the adoption of PR as well as carrying out logically related tasks in such a way that well-defined results are achieved. It reveals further that poor PR in APSOs has been a clog in the wheel of achieving high performance, efficient service delivery, public satisfaction, efficient management of resources, and sustainable development in Africa. This paper concludes that APSOs can fully adopt PR if they cut down on excessive bureaucracy and learn more from the private sector in terms of readiness and adaptability to environmental changes and transformation as advocated by the contingency theory (CT). The paper recommends, amongst others, that there should be the availability of information technology (IT) infrastructure and the willingness on the part of government representatives to deploy new technologies through adequate support for information technology companies and the prioritization of IT application's needs for high system automation. Managers of APSOs should be given the power to effect changes when the need arises, without any form of influence. Also, there should be concerns about the future of PSOs, and citizens who are clients thereof should be held in high esteem and not to be treated as ‘people in need of favour’. Finally, APSOs should embrace radical changes associated with PR especially by ensuring that promotions are based on merit and not on seniority alone.
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Talatahari, S., E. Khalili, and S. M. Alavizadeh. "Accelerated Particle Swarm for Optimum Design of Frame Structures." Mathematical Problems in Engineering 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/649857.

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Accelerated particle swarm optimization (APSO) is developed for finding optimum design of frame structures. APSO shows some extra advantages in convergence for global search. The modifications on standard PSO effectively accelerate the convergence rate of the algorithm and improve the performance of the algorithm in finding better optimum solutions. The performance of the APSO algorithm is also validated by solving two frame structure problems.
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Fakhar, Muhammad Salman, Syed Abdul Rahman Kashif, Noor Ul Ain, Hafiz Zaheer Hussain, Akhtar Rasool, and Intisar Ali Sajjad. "Statistical Performances Evaluation of APSO and Improved APSO for Short Term Hydrothermal Scheduling Problem." Applied Sciences 9, no. 12 (June 14, 2019): 2440. http://dx.doi.org/10.3390/app9122440.

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The Accelerated Particle Swarm Optimization (APSO) algorithm is an efficient and the easiest to implement variant of the famous Particle Swarm Optimization (PSO) algorithm. PSO and its variant APSO have been implemented on the famous Short-Term Hydrothermal Scheduling (STHTS) problem in recent research, and they have shown promising results. The APSO algorithm can be further modified to enhance its optimizing capability by deploying dynamic search space squeezing. This paper presents the implementation of the improved APSO algorithm that is based on dynamic search space squeezing, on the short-term hydrothermal scheduling problem. To give a quantitative comparison, a true statistical comparison based on comparing means is also presented to draw conclusions.
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Cheem, Tan Huay. "AICT - APSIC official scientific meeting." Catheterization and Cardiovascular Interventions 82, no. 2 (July 22, 2013): 169–70. http://dx.doi.org/10.1002/ccd.25086.

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Ferres, H. "Preclinical, pharmacological evaluation of APSAC." Thrombosis Research 45 (January 1987): 66. http://dx.doi.org/10.1016/0049-3848(87)90051-x.

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Cao, Ye-Xuan, Hui-Wen Zhang, Jing-Lu Jin, Hui-Hui Liu, Yan Zhang, Rui-Xia Xu, Ying Gao, et al. "Prognostic utility of triglyceride-rich lipoprotein-related markers in patients with coronary artery disease." Journal of Lipid Research 61, no. 9 (July 8, 2020): 1254–62. http://dx.doi.org/10.1194/jlr.ra120000746.

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TG-rich lipoprotein (TRL)-related biomarkers, including TRL-cholesterol (TRL-C), remnant-like lipoprotein particle-cholesterol (RLP-C), and apoC-III have been associated with atherosclerosis. However, their prognostic values have not been fully determined, especially in patients with previous CAD. This study aimed to examine the associations of TRL-C, RLP-C, and apoC-III with incident cardiovascular events (CVEs) in the setting of secondary prevention of CAD. Plasma TRL-C, RLP-C, and total apoC-III were directly measured. A total of 4,355 participants with angiographically confirmed CAD were followed up for the occurrence of CVEs. During a median follow-up period of 5.1 years (interquartile range: 3.9–6.4 years), 543 (12.5%) events occurred. Patients with incident CVEs had significantly higher levels of TRL-C, RLP-C, and apoC-III than those without events. Multivariable Cox analysis indicated that a log unit increase in TRL-C, RLP-C, and apoC-III increased the risk of CVEs by 49% (95% CI: 1.16–1.93), 21% (95% CI: 1.09–1.35), and 40% (95% CI: 1.11–1.77), respectively. High TRL-C, RLP-C, and apoC-III were also independent predictors of CVEs in individuals with LDL-C levels ≤1.8 mmol/l (n = 1,068). The addition of RLP-C level to a prediction model resulted in a significant increase in discrimination, and all three TRL biomarkers improved risk reclassification. Thus, TRL-C, RLP-C, and apoC-III levels were independently associated with incident CVEs in Chinese CAD patients undergoing statin therapy.
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Lee, Sookyoun. "The Advancement of the ASEAN Political Security Community (APSC) and Military Cooperation Development." JOURNAL OF INTERNATIONAL RELATIONS 23, no. 4 (December 31, 2020): 229–57. http://dx.doi.org/10.15235/jir.2020.12.23.4.229.

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Lee, Sookyoun. "The Advancement of the ASEAN Political Security Community (APSC) and Military Cooperation Development." JOURNAL OF INTERNATIONAL RELATIONS 23, no. 4 (December 31, 2020): 229–57. http://dx.doi.org/10.15235/jir.2020.12.23.4.229.

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33

Williams, John. "Adult safeguarding in Wales: one step in the right direction." Journal of Adult Protection 19, no. 4 (August 14, 2017): 175–86. http://dx.doi.org/10.1108/jap-05-2017-0021.

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Purpose The purpose of this paper is to consider the background to the recent changes to adult safeguarding in Wales as a result of the new measures introduced by the Social Services and Well-being (Wales) Act 2014 and discuss their potential impact. Design/methodology/approach The paper relies on a range of material including reports published by the Law Commission, the National Assembly for Wales and other public bodies. It also refers to academic and practitioner material in journals and government guidance. Findings Although the Social Services and Well-being (Wales) Act 2014 introduced many changes in adult safeguarding in Wales, not least the duty to make enquiries, it does not take the opportunity to include statutory powers of barring and removal. The introduction of Adult Protection and Support Orders (APSOs) is a cautious step forward – perhaps it is too cautious. More research in needed on the different approaches across the UK. Research limitations/implications At the time of publication, the full effect of the new legislation has not been seen. Local authorities and others are coming to terms with the new provisions. No data on the impact of the new legislation are yet available. The paper identifies future research evaluating the working of the different approaches to safeguarding within the UK. Practical implications For practitioners, the new legislation provides opportunities to rethink the approach to safeguarding. The lower threshold for referrals will mean an increase in caseloads and the need to react to both low- and high-risk cases. For authorised officers, the practical issues identified relate to the circumstances in which an APSO may be sought and what can be put in place to protect the adult at risk once the order has been used. Social implications For those who experience abuse or neglect, the new legislation provides additional support when compared to the POVA process. The duty to make enquiries and the duty to report will hopefully strengthen protection and, with a lower threshold for referral, enable more preventative work to be done at an earlier stage. Whether the new APSO will make a difference remains to be seen. Originality/value As this is new legislation, there is very little analysis of the implications of the Social Services and Well-being (Wales) Act 2014 in relation to safeguarding. This paper presents an overview and, in places, a critical analysis of the new safeguarding duties.
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Sprecher, D. L., L. Taam, R. E. Gregg, S. S. Fojo, D. M. Wilson, M. L. Kashyap, and H. B. Brewer. "Identification of an apoC-II variant (apoC-IIBethesda) in a kindred with apoC-II deficiency and type I hyperlipoproteinemia." Journal of Lipid Research 29, no. 3 (March 1988): 273–78. http://dx.doi.org/10.1016/s0022-2275(20)38533-3.

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Song, Zhaoyun, Bo Liu, and Hao Cheng. "Adaptive particle swarm optimization with population diversity control and its application in tandem blade optimization." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 233, no. 6 (May 22, 2018): 1859–75. http://dx.doi.org/10.1177/0954406218776680.

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This paper proposes a new variant of particle swarm optimization, namely adaptive particle swarm optimization with population diversity control (APSO-PDC), to improve the performance of particle swarm optimization. APSO-PDC is formulated based on adaptive selection of particle roles, population diversity control, and adaptive control of parameters. The adaptive selection of particle roles which combines the evolutionary state and dynamic particle state estimation method will sort the particles into three roles to let different particles execute different search tasks during optimization process. The adaptive control of parameters which is created based on the evolutionary state and particle roles encourages the exploitation ability and enhances the algorithm’s convergence speed. The population diversity control which combines comprehensive learning strategy of the comprehensive learning particle swarm optimizer with evolutionary state to update the individual best position strengthens exploration ability and thus increases the algorithm’s robustness toward the premature convergence issue. The performance of APSO-PDC is comprehensively evaluated by 21 unimodal and multimodal functions with or without rotation. The results indicate APSO-PDC has more preferable searching accuracy, searching reliability, and convergence speed than the other well-established particle swarm optimization variants. Finally, compared with other six particle swarm optimization variants, APSO-PDC shows satisfactory performance in optimizing tandem blade. This excellent performance proves that APSO-PDC has a better control of swarm exploration and exploitation abilities.
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Martinelli, Nicola, Marcello Baroni, Annalisa Castagna, Barbara Lunghi, Filippo Stefanoni, Federica Tosi, Jacopo Croce, et al. "Apolipoprotein C-III Strongly Correlates with Activated Factor VII–Anti-Thrombin Complex: An Additional Link between Plasma Lipids and Coagulation." Thrombosis and Haemostasis 119, no. 02 (January 2, 2019): 192–202. http://dx.doi.org/10.1055/s-0038-1676817.

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AbstractActivated factor VII–anti-thrombin (FVIIa-AT) complex is a potential biomarker of pro-thrombotic diathesis reflecting FVIIa–tissue factor (TF) interaction and has been associated with mortality in patients with coronary artery disease (CAD). Previous data indicated plasma lipids as predictors of FVIIa-AT variability, and plasma lipoproteins as potential stimulators of the coagulation cascade. Our aim was to evaluate the relationships between FVIIa-AT plasma concentration and a broad apolipoprotein profile (including ApoA-I, ApoB, ApoC-III and ApoE). Within the framework of the observational Verona Heart Study, we selected 666 subjects (131 CAD-free and 535 CAD, 75.4% males, mean age: 61.1 ± 10.9 years) not taking anticoagulant drugs and for whom plasma samples were available for both FVIIa-AT assay and a complete lipid profile. Plasma concentration of FVIIa-AT levels significantly and directly correlated with total and high-density lipoprotein cholesterol, triglycerides, ApoA-I, ApoC-III and ApoE levels. ApoC-III showed the strongest correlation (R = 0.235, p = 7.7 × 10−10), confirmed in all the sub-group analyses (males/females and CAD/CAD-free). Only ApoC-III remained associated with FVIIa-AT plasma concentration, even after adjustment for sex, age, CAD diagnosis, body mass index, renal function, smoking status, lipid-lowering therapies and FVIIa levels. The APOC3 gene locus-tagging polymorphism rs964184, previously linked with cardiovascular risk and plasma lipids by genome-wide association studies, was associated with both ApoC-III and FVIIa-AT plasma concentration. Our results indicate a strong association between ApoC-III and FVIIa-AT levels, thereby suggesting that an increased ApoC-III concentration may identify subjects with a pro-thrombotic diathesis characterized by an enhanced TF-FVIIa interaction and activity.
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Gunzburg, Menachem J., Matthew A. Perugini, and Geoffrey J. Howlett. "Structural Basis for the Recognition and Cross-linking of Amyloid Fibrils by Human Apolipoprotein E." Journal of Biological Chemistry 282, no. 49 (October 4, 2007): 35831–41. http://dx.doi.org/10.1074/jbc.m706425200.

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Apolipoprotein (apo) E is a well characterized lipid-binding protein in plasma that also exists as a common nonfibrillar component of both cerebral and systemic amyloid deposits. A genetic link between a common isoform of apoE, apoE4, and the incidence of late onset Alzheimer disease has drawn considerable attention to the potential roles of apoE in amyloid-related disease. We examined the interactions of apoE with amyloid fibrils composed of apoC-II and the amyloid-β (Aβ) peptide. Aggregates of apoE with Aβ and apoC-II are found in Alzheimer and atherosclerotic plaques, respectively. Sedimentation velocity and fibril size distribution analysis showed that apoE3 and E4 isoforms bind and noncovalently cross-link apoC-II fibrils in a similar manner. This ability to cross-link apoC-II fibrils was abolished by the dissociation of the apoE tetramer to monomers or by thrombin cleavage to yield separate N- and C-terminal domains. Preparative ultracentrifuge binding studies indicated that apoE and the isolated N- and C-terminal domains of apoE bind with submicromolar affinities to both apoC-II and Aβ fibrils. Fluorescence quenching and resonance energy transfer experiments confirmed that both domains of apoE interact with apoC-II fibrils and demonstrated that the binding of the isolated N-terminal domain of apoE to apoC-II or Aβ fibrils is accompanied by a significant conformational change with helix three of the domain moving relative to helix one. We propose a model involving the interaction of apoE with patterns of aligned residues that could explain the general ability of apoE to bind to a diverse range of amyloid fibrils.
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Wopereis, Suzan, Stephanie Grünewald, Éva Morava, Johannes M. Penzien, Paz Briones, M. Teresa Garcı́a-Silva, Pierre N. M. Demacker, Karin M. L. C. Huijben, and Ron A. Wevers. "Apolipoprotein C-III Isofocusing in the Diagnosis of Genetic Defects in O-Glycan Biosynthesis." Clinical Chemistry 49, no. 11 (November 1, 2003): 1839–45. http://dx.doi.org/10.1373/clinchem.2003.022541.

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Abstract Background: Defects in the biosynthesis of N-glycans may be found by isoelectric focusing (IEF) of plasma transferrin. No test is available to demonstrate O-glycan biosynthesis defects. Methods: We used isoforms of apolipoprotein C-III (apoC-III) as a marker for the biosynthesis of core 1 mucin type O-glycans. Plasma samples from patients with primary defects and secondary alterations in N-glycan biosynthesis were studied by apoC-III isofocusing. Results: Age-related reference values for apoC-III were determined. Plasma samples from patients with the primary congenital disorders of glycosylation (CDG) types Ia–Ic, Ie, If, IIa, and IId all showed a normal apoC-III isofocusing profile. Plasma from two patients with CDG type IIx were tested: one showed a normal apoC-III distribution, whereas the other showed a hypoglycosylation profile. In plasma from patients with hemolytic uremic syndrome (HUS), a hypoglycosylation profile was obtained. Conclusions: IEF of apoC-III is a rapid and simple technique that may be used as a screening assay for abnormalities in core 1 mucin type O-glycans. Evidence that a patient in this study has a primary genetic defect affecting both N- and O-glycosylation provides the first example of an inborn error of metabolism affecting the biosynthesis of core 1 mucin type O-glycans. Our data narrow the options for the position of the primary defect in this patient down to a step in the biosynthesis, activation, or transfer of galactose or N-acetylneuraminic acid to both N- and O-glycans. Circulating neuraminidase excreted by Streptococcus pneumoniae caused the high percentage of asialo apoC-III in two HUS patients.
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Saini, Manish Kumar, and Rajiv Kapoor. "Image compression using APSO." International Journal of Artificial Intelligence and Soft Computing 3, no. 1 (2012): 70. http://dx.doi.org/10.1504/ijaisc.2012.048180.

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Ondrušková, Nina, Tomáš Honzík, Jitka Kytnarová, Martin Matoulek, Jiří Zeman, and Hana Hansíková. "Isoelectric Focusing of Serum Apolipoprotein C-III as a Sensitive Screening Method for the Detection of O-glycosylation Disturbances." Prague Medical Report 116, no. 2 (2015): 73–86. http://dx.doi.org/10.14712/23362936.2015.48.

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Apolipoprotein C-III (ApoC-III) is a glycoprotein carrying the most common O-linked glycan structure and is abundantly present in serum, what renders it a suitable marker for analysis of O-glycosylation abnormalities. Isoelectric focusing followed by a Western blot of ApoC-III, using PhastSystem™ Electrophoresis System (GE Healthcare), was introduced as a rather simple and rapid method for screening of certain subtypes of inherited glycosylation disorders. The study’s aim was to establish this method in our laboratory, what included performing the analysis in a group of 170 healthy individuals to set the reference range of detected relative amounts of sialylated ApoC-III isoforms and to evaluate the gender- and age-dependent differences. A significant relative increase of asialo-ApoC-III with growing age was found. Secondly, we examined serum from patients with selected metabolic disorders and detected minor O-glycosylation changes in diseases such as Prader-Willi syndrome, PGM1 (phosphoglucomutase 1) or MAN1B (class 1B alpha-1,2-mannosidase) deficiency. Our results show that this method allows for a sensitive detection of ApoC-III O-glycosylation status, however this might be modulated by several factors (i.e. nutrition, medication) whose exact role remains to be determined.
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Wang, Gai-Ge, Amir Hossein Gandomi, Xin-She Yang, and Amir Hossein Alavi. "A novel improved accelerated particle swarm optimization algorithm for global numerical optimization." Engineering Computations 31, no. 7 (September 30, 2014): 1198–220. http://dx.doi.org/10.1108/ec-10-2012-0232.

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Purpose – Meta-heuristic algorithms are efficient in achieving the optimal solution for engineering problems. Hybridization of different algorithms may enhance the quality of the solutions and improve the efficiency of the algorithms. The purpose of this paper is to propose a novel, robust hybrid meta-heuristic optimization approach by adding differential evolution (DE) mutation operator to the accelerated particle swarm optimization (APSO) algorithm to solve numerical optimization problems. Design/methodology/approach – The improvement includes the addition of DE mutation operator to the APSO updating equations so as to speed up convergence. Findings – A new optimization method is proposed by introducing DE-type mutation into APSO, and the hybrid algorithm is called differential evolution accelerated particle swarm optimization (DPSO). The difference between DPSO and APSO is that the mutation operator is employed to fine-tune the newly generated solution for each particle, rather than random walks used in APSO. Originality/value – A novel hybrid method is proposed and used to optimize 51 functions. It is compared with other methods to show its effectiveness. The effect of the DPSO parameters on convergence and performance is also studied and analyzed by detailed parameter sensitivity studies.
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Cohn, Jeffrey S., Rami Batal, Michel Tremblay, Hélène Jacques, Lyne Veilleux, Claudia Rodriguez, Orval Mamer, and Jean Davignon. "Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans." Journal of Lipid Research 44, no. 10 (July 16, 2003): 1976–83. http://dx.doi.org/10.1194/jlr.m300209-jlr200.

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Chen, Keqiao. "APSO-LSTM: An Improved LSTM Neural Network Model Based on APSO Algorithm." Journal of Physics: Conference Series 1651 (November 2020): 012151. http://dx.doi.org/10.1088/1742-6596/1651/1/012151.

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44

Colebunders, Robert. "COVID-19: The African Enigma." Colombia Medica 52, no. 2 (April 24, 2021): e7014816. http://dx.doi.org/10.25100/cm.v52i2.4816.

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To the editor Related article: https://colombiamedica.univalle.edu.co/...iew/4613 We read with interest the paper by Guerrero et al “COVID-19: The Ivermectin African Enigma” . In an ecological study they compared COVID-19 related mortality and infection rates between APOC (African Programme for Onchocerciasis Control) and non-APOC countries. After adjusting for Human Development Index (HDI) and number of performed test, COVID-19 mortality and infection rate were respectively 28% and 8% lower in non-APOC countries compared to APOC countries. The authors suggested that this difference may be related to the community directed treatment with ivermectin (CDTI) programs established in APOC countries. We agree that it remains to be explained why a lower COVID-19 mortality is observed in many APOC countries compared to other parts of the world. However, we do not believe that this is related to CDTI programs. Indeed, in APOC countries ivermectin is distributed only once (most countries) or twice a year 2. Moreover, April 1st 2020, because of the COVID-19 pandemic, CDTI programs were interrupted and were only recently restarted. Ivermectin has an in vitro anti-COVID-19 effect and also certain clinical trials suggested a beneficial effect of ivermectin on COVID-19 disease outcome. However, in a recent small double blind, randomized control trial in Colombia, five days of ivermectin, at a 10 times the recommended dose, did not reduce the duration of symptoms of mild COVID-19 disease compared to placebo. Given the half-life of ivermectin, approximately 18h, it is unlikely that CDTI, only one dose of ivermectin once or twice a year, may be able to reduce COVID-19 related mortality. Many factors could explain the lower COVID-19 mortality in APOC countries. One of them could be exposure to parasitic infections and the immune response induced by these infections. For example, for P. falciparum, a parasitic infection highly prevalent in APOC countries, it has been hypothesised that the immunological memory against P. falciparum merozoites primes SARS-CoV-2 infected cells for early phagocytosis and therefore may protect persons with a recent P. falciparum infection against severe COVID-19 disease. Helminth infections, such as onchocerciasis, may down regulate immune responses and potentially inactivate the inflammatory signalling pathways that may induce acute respiratory distress syndrome (ARDS), one of the causes of death in COVID-19 infected persons
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45

Ueda, Masako, Richard L. Dunbar, Anna Wolska, Tracey U. Sikora, Maria del Rosario Escobar, Naomi Seliktar, Emil deGoma, et al. "A Novel APOC2 Missense Mutation Causing Apolipoprotein C-II Deficiency With Severe Triglyceridemia and Pancreatitis." Journal of Clinical Endocrinology & Metabolism 102, no. 5 (February 13, 2017): 1454–57. http://dx.doi.org/10.1210/jc.2016-3903.

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Abstract Context: Familial chylomicronemia syndrome (FCS) is a rare heritable disorder associated with severe hypertriglyceridemia and recurrent pancreatitis. Lipoprotein lipase deficiency and apolipoprotein C-II deficiency are two well-characterized autosomal recessive causes of FCS, and three other genes have been described to cause FCS. Because therapeutic approaches can vary according to the underlying etiology, it is important to establish the molecular etiology of FCS. Case Description: A man originally from North Africa was referred to the University of Pennsylvania Lipid Clinic for severe hypertriglyceridemia and recurrent pancreatitis, consistent with the clinical diagnosis of FCS. Molecular analyses of FCS-associated genes revealed a homozygous missense variant R72T in APOC2. Molecular modeling of the variant predicted that the apolipoprotein C-II R72T peptide has reduced lipid binding affinity. In vitro studies of the patient’s plasma confirmed the lack of functional apoC-II activity. Moreover, the apoC-II protein was undetectable in the patient’s plasma, quantitatively as well as qualitatively. Conclusions: We identified a missense APOC2 variant causing apoC-II deficiency in a patient with severe hypertriglyceridemia and recurrent pancreatitis. Beyond dietary management and usual pharmacologic therapies, an apoC-II mimetic peptide may become an optional therapy in patients with apoC-II deficiency in the future.
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46

Mishra, Satyasis, Premananda Sahu, and Manas Ranjan Senapati. "APSO based LLRBFNN Model and Enhanced Fuzzy C Means algorithm for Brain Tumor Detection and Classification from Magnetic Resonance Image." International Journal of Engineering & Technology 8, no. 4 (November 5, 2019): 490. http://dx.doi.org/10.14419/ijet.v8i4.20445.

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This paper presents a novel APSO (Accelerated Particle Swarm Optimization) Predicated LLRBFNN (Local Linear Radial Basis Function Neural Network) model for automatic encephalon tumor detection and classification. The enhanced fuzzy c means algorithm (EnFCM) has been proposed for image segmentation and the GLCM (Gray Level Co-occurrence Matrix) technique for feature extraction from MR (Magnetic Resonance) images. This research work aims to utilize the hybrid models and algorithms for relegation and segmentation of encephalon tumors from the MR images. The extracted features have been alimented as input to the proposed APSO predicated LLRBFNN model for relegation of benign and malignant tumors. In this research work the proposed LLRBFNN model weights are optimized by utilizing APSO training which will provide unique solution to mitigation the hectic task of radiologist from manual detection of encephalon tumors from MR Images. Additionally the centers of the LLRBFNN model are culled by the Enhanced Fuzzy C Means algorithm and updated by the APSO algorithm. The results of proposed PSO predicated LLRBFNN model has been compared with PSO-LLRBFNN model, APSO-RBFNN and PSO-RBFNN model and the comparison results are presented. The experimental results obtained from the proposed model shows better relegation results as compared to the subsisting models proposed anteriorly.
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47

Lenin, K. "REDUCTION OF REAL POWER LOSS BY ADVANCED PARTICLE SWARM OPTIMIZATION ALGORITHM." International Journal of Research -GRANTHAALAYAH 6, no. 2 (February 28, 2018): 166–81. http://dx.doi.org/10.29121/granthaalayah.v6.i2.2018.1560.

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This paper presents Advanced Particle Swarm Optimization (APSO) algorithm for solving optimal reactive power problem. In this work Biological Particle swarm Optimization algorithm utilized to solve the problem by eliminating inferior population & keeping superior population, to make full use of population resources and speed up the algorithm convergence. Projected Advanced Particle Swarm Optimization (APSO) algorithm has been tested on standard IEEE 30 bus test system and simulation results shows clearly about the superior performance of the proposed Advanced Particle Swarm Optimization (APSO) algorithm in reducing the real power loss and static voltage stability margin (SVSM) Index has been enhanced.
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48

Al-Hokbany, N. S., Basim Alotaibi, Suad Bin Amer, Subhani M. Okarvi, and Ibrahim Al-Jammaz. "Synthesis andIn VitroandIn VivoEvaluation of a New68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging." Journal of Chemistry 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/616459.

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In an attempt to develop new tumor imaging radiotracers with favorable biochemical properties, we have synthesized new68Ga-2-acetylpyridine semicarbazone (68Ga-[APSC]2) as a potential positron emission tomography (PET) tumor imaging agent using a straightforward and a one-step simple reaction. Radiochemical yield and purity were quantitative without HPLC purification. Biodistribution studies in nude mice model bearing human MDA-MB-231 cell line xenografts displayed significant tumor uptake of68Ga-[APSC]2radiotracer after 2 h postinjection (p.i.). The initial results demonstrate that68Ga-[APSC]2radiotracer may be useful probe for detecting and staging of hypoxic tumor using PET imaging modality.
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Pattanayak, Suvranshu, Bibhuti Bhusan Choudhury, Soubhagya Chandra Sahoo, and Subham Agarwal. "An Effective Track Designing Approach for a Mobile Robot." International Journal of Natural Computing Research 8, no. 3 (July 2019): 26–40. http://dx.doi.org/10.4018/ijncr.2019070102.

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Advancements of technology in day to day life demands upgradation in the existing soft computing approaches, for enhancing the accuracy. So, the existing particle swarm optimization (PSO) has been upgraded in this article and the new approach is adaptive particle swarm optimization (APSO). Designing an effective track which is shorter in length, takes less travel time, computation time, smooth, feasible and has zero collision risk with obstacles is always a crucial issue. To solve these issues APSO approach has been adopted in this work. A static environment has been implemented in this article for conducting the simulation study. Fifteen numbers of obstacles have been taken into consideration for designing the environment. A comparability study has been stuck between PSO and APSO to recognize the fittest approach for track design (less track size and travel time) with the shortest computation time. The APSO approach is identified as the best suited track designing tool for mobile robots.
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Schmitz, Joel, and Ioanna Gouni-Berthold. "APOC-III Antisense Oligonucleotides: A New Option for the Treatment of Hypertriglyceridemia." Current Medicinal Chemistry 25, no. 13 (May 7, 2018): 1567–76. http://dx.doi.org/10.2174/0929867324666170609081612.

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Elevated triglyceride levels (higher than ~1000 mg/dL) are associated with an increased risk for pancreatitis. Apolipoprotein-CIII (apoC-III) plays a key role in the metabolism of triglycerides and triglyceride-rich lipoproteins. Loss of function mutations in the gene encoding apoC-III (APOC3) is associated with low triglyceride levels and a decreased risk for cardiovascular disease (CVD) while overexpression of APOC3 is associated with hypertriglyceridemia. Although many drugs such as fibrates, statins and omega-3 fatty acids modestly decrease triglyceride levels (and apoC-III concentrations), there are many patients who still have severe hypertriglyceridemia and are at increased risk for pancreatitis and potentially for CVD. The antisense oligonucleotide (ASO) against APOC3 mRNA volanesorsen (previously called ISIS 304801, ISIS-ApoCIIIRx and IONIS-ApoCIIIRx) robustly decreases both, apoC-III production and triglyceride concentrations and is being currently evaluated in phase 3 trials. In this narrative review, we present the currently available clinical evidence on the efficacy and safety of volanesorsen for the treatment of hypertriglyceridemia.
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