Academic literature on the topic 'Aquilaria malaccensis'

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Journal articles on the topic "Aquilaria malaccensis"

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Fitriani, Nyayu, and Putri Erlyn. "Aktivitas Antidiabetik Kombinasi Ekstrak Etanol Daun Ciplukan (Physalis angulata) dan Daun Gaharu (Aquilaria malaccensis) pada Tikus Diabetes." Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan 9, no. 2 (2019): 70. http://dx.doi.org/10.32502/sm.v9i2.1660.

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Daun Aquilaria malaccensis dan Physalis angulata merupakan jenis tanaman yang sering digunakan sebagai antidiabetes karena memiliki berbagai senyawa aktif, seperti terpenoid pada daun Physalis angulata dan flavonoid pada daun Aquilaria malaccensis. Penelitian ini bertujuan untuk mengetahui aktivitas antidiabetik kombinasi ekstrak etanol daun Aquilaria malaccensis dan daun Physalis angulata pada tikus diabetes. Penelitian ini menggunakan desain eksperimental dengan pre and post test control group design. Hewan uji yang digunakan dibagi dalam 4 kelompok, yaitu kelompok yang diberikan glibenklamid 130 mg/kgBB (kontrol positif), aquadest (kontrol negatif), kombinasi ekstrak daun Aquilaria malaccensis 5 mg/kgBB dan daun Physalis angulata 50 mg/kgBB, kombinasi ekstrak daun Aquilaria malaccensis 10 mg/kgBB dan daun Physalis angulata 100 mg/kgBB. Analisis data menggunakan uji T-berpasangan dan Post Hoc. Hasil uji T-berpasangan menunjukkan pada kelompok aquadest, glibenklamid dan kombinasi ekstrak terjadi penurunan bermakna kadar glukosa darah puasa sebelum dan sesudah perlakuan (p<0.05) dan hasil uji Post Hoc didapatkan bahwa tidak terdapat perbedaan yang bermakna antara kedua kelompok kombinasi ekstrak daun Aquilaria malaccensis dan daun Physalis angulata dengan glibenklamid dalam menurunkan kadar gula darah puasa (p>0.05). Sehingga kombinasi kedua ekstrak daun ini efektif dalam menurunkan kadar glukosa darah puasa pada tikus diabetes.
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Aris Suhardiman, Hana Hanifah, Asep Roni, and Aiyi Asnawi. "Cytotoxic activities of extract and fraction of agarwood leaves (aquaria malaccensis Lam) as herbal medicine on MCF-7 cancer cells." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1012–18. http://dx.doi.org/10.26452/ijrps.v11ispl4.4237.

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MCF-7 cell is a cell line widely used in studied breast cancer. Breast cancer is one type of cancer that has a high prevalence in the world, including Indonesia. Agarwood leaves (Aquilaria malaccensis Lam) is one of the plants known to possess antioxidant activity. This study aims to determine the cytotoxic activity of extracts and fractions of Agarwood leaves (Aquilaria malaccensis Lam) against MCF-7 cancer cells. Agarwood leaves (Aquilaria malaccensis Lam) were extracted using the maceration method with 96% ethanol and followed by fractionation using n-hexane, ethyl acetate, and methanol: water as a solvent. Phytochemical screening test results Agarwood leaves extract (Aquilaria malaccensis Lam) contains alkaloid compounds flavonoids, quinones, tannins, saponins, steroids and triterpenoids. The results of thin-layer chromatography monitoring showed that the extract and fraction of Agarwood leave hexane had active flavonoid compounds. The extracts and its fractions were tested for cytotoxic activity against MCF-7 cell line using MTT Assay [3- (4,5 dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide]. The results showed IC50 values for extract, methanol:water fraction, ethyl acetate fraction, and n-hexane fraction were 728.412 µg/mL, 505.026 µg/mL, 1881.482 µg/mL, and 144.458 µg/ mL, respectively.The n-hexane fraction of Agarwood leaves (Aquilaria malaccensis Lam) has the best cytotoxic activity against MCF-7 cancer cells and has the potential to be developed as an anti-cancer herbal medicine.
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Eissa, Manar A., Yumi Z. H.-Y. Hashim, Dina M. El-Kersh, et al. "Metabolite Profiling of Aquilaria malaccensis Leaf Extract Using Liquid Chromatography-Q-TOF-Mass Spectrometry and Investigation of Its Potential Antilipoxygenase Activity In-Vitro." Processes 8, no. 2 (2020): 202. http://dx.doi.org/10.3390/pr8020202.

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The Aquilaria malaccensis species of the genus Aquilaria is an abundant source of agarwood resin and many bioactive phytochemicals. Recent data regarding the chemical constituents and biological activities of Aquilaria leaves led us to attempt to qualitatively profile the metabolites of Aquilaria malaccensis leaves from a healthy, noninoculated tree through phytochemical screening, GC-MS, and LC/Q-TOF-MS. The present work is also the first to report the antilipoxygenase activity of A. malaccensis leaves from healthy noninoculated tree and investigate its toxicity on oral mucosal cells. A total of 53 compounds were tentatively identified in the extract, some of which have been described in literature as exhibiting anti-inflammatory activity. A number of compounds were identified for the first time in the extract of A. malaccensis leaf, including quercetin, quercetin-O-hexoside, kaempferol-O-dirhamnoside, isorhamnetin-O-hexoside, syringetin-O-hexoside, myricetin, tetrahydroxyflavanone, hesperetin, sissotrin, and lupeol. The antilipoxygenase assay was used to determine the lipoxygenase (LOX) inhibitory potential of the extract, while a WST-1 assay was conducted to investigate the effect of the extract on oral epithelial cells (OEC). The extract implied moderate anti-LOX activity with IC50 value of 71.6 µg/mL. Meanwhile, the cell viability of OEC ranged between 92.55% (10 µg/mL)–76.06% ± (100 µg/mL) upon treatment, indicating some potential toxicity risks. The results attained encourage future studies of the isolation of bioactive compounds from Aquilaria malaccensis leaves, as well as further investigation on the anti-inflammatory mechanisms and toxicity associated with their use.
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Wijayanti, Dian Rachma, and Maman Turjaman. "Isolation and Characterization Of Arbuscular Mychorhiza Fungi from Gaharu Wood (Aquilaria spp.) Rhizosphere." BioEksakta : Jurnal Ilmiah Biologi Unsoed 2, no. 3 (2020): 297. http://dx.doi.org/10.20884/1.bioe.2020.2.3.3090.

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In the last 30 years there have been increasing demand of agarwood. Unlimited hunting of agarwood causing it become threatened species. Aquilaria spp. is the main genus producing agarwood that considered as threathened species. Conserving Aquilaria spp. as germ plasm needs is essential against destruction. Arbuscular mycorrhizal fungi (AMF) have been used as inoculant to increase the growth of Aquilaria spp., but information about the existence of AMF in Aquilaria spp. rhizosphere has not been reported. This research was carried out with objective to identify AMF from Aquilaria spp. rhizosphere. Soil and root samples from rhizosphere of Aquilaria spp. taken from four location that is: Carita (A. malaccensis), Ciapus (A. filaria), Cifor (A. crasna & A. malaccensis), and Bantar Kemang (A. beccariana, A. crasna, & A. malaccensis). Roots staining was conducted with modified Phillips and Hayman procedure (1970). Soils sample was run dry wed and placed in pot culture with Pueraria javanica as the host plant. Spore was separated from pot culture using wet sieving and decanting method continued with centrifugation. The result showed the occurrences of AMF in Aquilaria spp. roots i.e. external hypha, internal hypha, coiled hypha, arbuscules, and vesicles. All AMF colony structure found in Aquilaria spp. roots show asosiation bettwen the plant and AMF. Four species of AMF were found i.e. Glomus sp.1, Glomus sp.2, Gigaspora albida, and Dentiscutata sp.
 Key Words: Isolation, Arbuscule Mycorrhizae Fungi, Rhizosfer, Agarwood
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Piancita, Giga, Indriyanto -, and Duryat -. "PENGARUH DOSIS BIOSERUM TERHADAP PEMBENTUKAN GAHARU PADA Aquilaria malaccensis Lamk." Jurnal Hutan Tropis 9, no. 1 (2021): 101. http://dx.doi.org/10.20527/jht.v9i1.10482.

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Natural agarwood takes a long time to be formed in nature, therefore an improvement technique was required in order to increase the productivity of Agarwood. One of these techniques was Bioserum injection into the Aquilaria malaccensis. Bioserum is a nutritious liquid necessary for fungi to live, grow and produce the agarwood. The purpose of the research was to determine the best Bioserum dosage, the best time of Bioserum reacted, and the best interaction between the two factors in the formation of agarwood. Factorial Completely Randomized Design (FCRD) with two factors, namely the dosage of Bioserum and time of Bioserum reacted in the Aquilaria malaccensis, was employed as the research design. The dosage of Bioserum applicated was 0 ml, 2 ml, 3 ml, and 4 ml with 3 replications. The time of Bioserum reacted in the Aquilaria malaccensis was 1 month, 2 months, and 3 months. The results showed that the best dosage of Bioserum to form the agarwood was 4 ml/hole. The best time of Bioserum reacted in the Aquilaria malaccensis to form the agarwood was 3 months. The best of interaction between of the two factors to form the agarwood was the Bioserum dosage of 4 ml with the time of Bioserum reacted of 3 months.
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Hishamuddin, Muhammad Syahmi, Shiou Yih Lee, Nurulfiza Mat Isa, Dhilia Udie Lamasudin, Syafiq Asnawi Zainal Abidin, and Rozi Mohamed. "Time-based LC-MS/MS analysis provides insights into early responses to mechanical wounding, a major trigger to agarwood formation in Aquilaria malaccensis Lam." RSC Advances 9, no. 32 (2019): 18383–93. http://dx.doi.org/10.1039/c8ra10616a.

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Nelly Marliani. "A REVIEW: AQUILARIA SPECIES AS POTENTIAL OF PHARMACOLOGICAL." OISAA Journal of Indonesia Emas 4, no. 2 (2021): 49–53. http://dx.doi.org/10.52162/jie.2021.004.02.2.

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One of the plants that is rich in benefits is from the genus Aquilaria spp. which is known to be able to produce agarwood resin. This genus includes 47 species, of which the four main species are Aquilaria malaccensis, Aquilaria subintegra, Aquilaria crassna and Aquilaria sinensis. Aquilaria species are known to have a wide spectrum of pharmacological activity and have been reported in many studies, including activity, anticancer, anti-inflammatory, AChE inhibitor (Acetylcholinesterase), anti-proliferative, and antidiabetic. The aim of this review is to expand information on the pharmacological activity of various Aquilaria species that can support future studies in the medical field of medicine.
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Leksono, Anisa, and Erni Sofia Murtini. "EFFECTS OF FERMENTATION DURATION ON PHYSICOCHEMICAL AND ORGANOLEPTIC CHARACTERISTICS OF THREE AGARWOODS (Aquilaria) LEAVES TEA." Jurnal Pangan dan Agroindustri 9, no. 2 (2021): 73–82. http://dx.doi.org/10.21776/ub.jpa.2021.009.02.1.

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Aquilaria is one of the plant genus-producing agarwood. Aquilaria leaves have pharmacological effects which the potential to be processed into black tea. The aim of this study is to determine the effect of fermentation duration on physicochemical and organoleptic characteristics of Aquilaria leaves tea. This study employed a Completely Randomized Design with two factors; the plant species (A. crassna, A. malaccensis, and A. subintegra) and fermentation duration (0 minutes, 70 minutes, and 90 minutes). Parameters analyzed including water content, total phenol, and antioxidant activity. Organoleptic tests were performed on the color, taste, and aroma of the brewed tea. The results summarized that A. subintegra had the highest total phenol and antioxidant activity, but the taste of the tea was not favored. A. crassna fermented 70 minutes and A. malaccensis fermented 0 minutes were the most preferred, but both have lower total phenol and antioxidant activity than A. subintegra.
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Ma, CT, B. Wu, SW Kwon, and JH Park. "Chemical constituents of agarwood from Aquilaria malaccensis." Planta Medica 81, S 01 (2016): S1—S381. http://dx.doi.org/10.1055/s-0036-1597079.

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Mat Rashid, Zalilawati, Nur Nasyitah Mohd Nasir, Wan Nadilah Wan Ahmad та Nor Hasima Mahmod. "α-glucosidase Inhibition, DPPH Scavenging and Chemical Analysis of Polysaccharide Extracts of Aquilaria sp. Leaves". Journal Of Agrobiotechnology 11, № 2 (2020): 59–69. http://dx.doi.org/10.37231/jab.2020.11.2.225.

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Aquilaria sp. belongs to Thymelaeaceae family. This genus produces a unique fragrant wood locally known as ‘gaharu’. It is well known for usages in aromatherapy while very few scientific evidence on its usage as herbal medicine have been published. The current study was therefore conducted to determine the chemical characteristics as well as antioxidant and α-glucosidase inhibition potential of carbohydrate-rich extracts (aqueous and polysaccharide extracts) of three Aquilaria species leaves (A. malaccensis, A. sinensis and A. subintegra). The isolation of polysaccharide (PS) from the aqueous extract (AE) was conducted by ethanol precipitation prior to ultrasonic-assisted extraction. The total phenolic content (TPC), proximate and Fourier Transform Infrared Spectroscopy (FTIR) analysis were carried out to investigate the chemical characteristics, while the bioactivities determined were 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and α-glucosidase inhibition. As a result, AE of A. malaccensis leaves showed the strongest α-glucosidase (IC50: 0.094 mg/mL) and DPPH (IC50: 0.094 mg/mL) inhibition while contained more TPC (61.16 mg GAE/g) compared to other two species. Furthermore, PS of A. malaccensis leaves displayed even stronger α-glucosidase inhibition (IC50: 0.014 mg/mL) compared to its respective AE and other PS. In conclusion, this study primarily revealed the scientific evidence on the bioactive potential of PS of Aquilaria sp.
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Dissertations / Theses on the topic "Aquilaria malaccensis"

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Muhammad, Norwati. "Genetic diversity and breeding system of Aquilaria malaccensis Lamarck." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270210.

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Chiu, Sara Jane Soo Hoon. "In vitro cultures of Aquilaria malaccensis for agarwood production." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33954/.

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This thesis describes the results of a series of plant tissue culture, chemical and molecular based experiments aimed at developing an in vitro system to study the fundamental changes in chemical composition or activation of specific chemical pathways which take place during the onset and production of agarwood in Aquilaria malaccensis. Cell suspension cultures were established using callus initiated from shoot and leaf segments excised from in vitro grown plantlet of Aquilaria malaccensis. Callus was successfully established and maintained by culturing leaf segments on MS medium supplemented with 3% sucrose, 0.3% phytagel, 2.2µM of 2,4-D and 2.3 µM of BAP, and cultured under ambient culture condition i.e. 28 ± 2 ºC under continuous dark conditions. Cell suspensions were initiated from the callus lines using the same medium composition, but without the gelling agent and placed on a rotary shaker at 75 rpm. Leaf-derived callus (CS 11) was identified as the preferred source of callus due to the formation of a more homogenous cell suspension cultures which maintained continuous growth after many rounds of sub-culturing. Cell line CS 11 was used for further studies, i.e. determining the effect of elicitation on cell growth, biochemical change and gene expression. In order to effectively study the biochemical changes (sesquiterpenes and chromones production) within the cells in cultures, it would first be necessary to devise suitable analytical methods which would enable the analysis of the effect of elicitation, and to study the chemical profile of each cell culture lines. Various analytical techniques were evaluated using agarwood oil extracts (as standards) and cell cultures as target material. Solid phase micro extraction (SPME) was found to be the most effective technique in detecting the presence of sesquiterpenes and chromones within the cells in cultures. Four sesquiterpenes (alpha humulene, delta guaiene, beta caryophyllene, alpha guaiene) and four chromones (6-methoxy-2-(2-phenylethyl)- chromone, 5,8-dihydroxy-2-(2-(4-methoxyphenylethyl)-chromone, 7-hydroxy-2-(2-phenyl ethyl] chromone and 6-methoxy-2-[2-(3-methoxyphenyl)ethyl] chromones) were found to be produced in unstressed cell suspensions. However it was important to note that although chromones were detected there was no consistent production of any chromones in cell cultures. Overall, the production of sesquiterpenes in cell suspension cultures was found to be higher following elicitation using methyl jasmonate, salicylic acid and ethanol. While salicylic acid was found to enhance cell growth, methyl jasmonate was found to suppress the growth of cells. Unexpectedly the addition of alcohol (0.17µM), the solvent used to dissolve methyl jasmonate was found to have an effect on the production of sesquiterpenes specifically when applied separately where, it was found to induce higher concentration of alpha guaiene and alpha humulene as compared to methyl jasmonate or salicylic acid treatments. The correlation of increase in the production of sesquiterpenes in relation to sesquiterpene synthase expression was also explored in a preliminary study done using the ACL 154 primers whereby the increase in alpha humulene production was found to correlate with an increase in delta guaiene synthase activity suggesting that delta guaiene synthase may be responsible for alpha humulene production in Aquilaria malaccensis. In summary, the combined results of the above studies led to the development of a series of analytical methods and the establishment of an in vitro model system for Aquilaria malaccensis using cell cultures. This represents the first study successfully examining the simulated effect of artificially induced wound (elicitation), in terms of its direct influence on sesquiterpenes profile expressed, and an insight to gene expression patterns which take place within cell cultures of Aquilaria malaccensis.
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Books on the topic "Aquilaria malaccensis"

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Gunn, Brian. A strategy for biological conservation and management of eaglewood and its product "gaharu" in Papua New Guinea. CSIRO Forestry and Forest Products, 2004.

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Siran, Sulistyo A., and Maman Turjaman. Pengembangan teknologi produksi gaharu berbasis pemberdayaan masyarakat. Edited by Pusat Penelitian dan Pengembangan Hutan dan Konservasi Alam (Indonesia). Pusat Penelitian dan Pengembangan Hutan dan Konservasi Alam, 2010.

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Book chapters on the topic "Aquilaria malaccensis"

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Mustaqim, Wendy A. "Aquilaria malaccensis Lam. Thymelaeaceae." In Ethnobotany of Mountain Regions. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-14116-5_169-1.

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Mustaqim, Wendy A. "Aquilaria malaccensis Lam. Thymelaeaceae." In Ethnobotany of Mountain Regions. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-38389-3_169.

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Tajuddin, Saiful Nizam, Che Mohd Aizal, and Mashitah Mohd Yusoff. "Resolution of Complex Sesquiterpene Hydrocarbons in Aquilaria malaccensis Volatile Oils Using Gas Chromatography Technique." In Tropical Forestry. Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0833-7_7.

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Ali, Nor Azah Mohamad, Chee Beng Jin, and Mailina Jamil. "Agarwood (Aquilaria malaccensis) Oils." In Essential Oils in Food Preservation, Flavor and Safety. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-416641-7.00018-3.

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Parthasarathy, S., G. Thiribhuvanamala, P. Muthulakshmi, and K. Angappan. "Diseases of Aquilaria malaccensis (Agarwood)." In Diseases of Forest Trees and their Management. CRC Press, 2021. http://dx.doi.org/10.1201/9781003173861-12.

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Bakansing, Shirley Marylinda, Mohd Hamami Sahri, and Kang Chiang Liew. "Wood Anatomical Structure of Aquilaria malaccensis Associated with Agarwood Occurrence and the Uses of Agarwood." In Prospects and Utilization of Tropical Plantation Trees. CRC Press, 2019. http://dx.doi.org/10.1201/9780429442773-7.

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Conference papers on the topic "Aquilaria malaccensis"

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Batubara, Ridwanti, Basuki Wirjosentono, Amir Hamzah Siregar, Tamrin, and Urip Harahap. "Chemical content analysis of agarwood (Aquilaria malaccensis Lamk) twigs." In THE INTERNATIONAL CONFERENCE ON CHEMICAL SCIENCE AND TECHNOLOGY (ICCST – 2020): Chemical Science and Technology Innovation for a Better Future. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0046395.

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Rahman, Nurul Ain Noor, Mohd Nazip Suratman, Ab Rasip Ab Ghani, and Tsan Fui Ying. "Incorporating agroforestry practices in Karas (Aquilaria malaccensis) plantations in Malaysia." In 2012 IEEE Symposium on Business, Engineering and Industrial Applications (ISBEIA). IEEE, 2012. http://dx.doi.org/10.1109/isbeia.2012.6422864.

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Hendra, Hadi, Sukarti Moeljopawiro, and Tri Rini Nuringtyas. "Antioxidant and antibacterial activities of agarwood (Aquilaria malaccensis Lamk.) leaves." In TECHNOLOGIES AND MATERIALS FOR RENEWABLE ENERGY, ENVIRONMENT AND SUSTAINABILITY: TMREES. Author(s), 2016. http://dx.doi.org/10.1063/1.4958565.

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Nurul Ain Noor Rahman, Mohd Nazip Suratman, Ab Rasip Ab Ghani, and Tsan Fui Ying. "Diameter patterns of 5-year old Karas (Aquilaria malaccensis) agroforestry stands." In 2011 IEEE Symposium on Business, Engineering and Industrial Applications (ISBEIA). IEEE, 2011. http://dx.doi.org/10.1109/isbeia.2011.6088782.

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Ali, Nor Azah Mohd, Nurlaila Ismail, and Mohd Nasir Taib. "Analysis of Agarwood oil (Aquilaria Malaccensis) based on GC-MS data." In 2012 IEEE 8th International Colloquium on Signal Processing & its Applications (CSPA). IEEE, 2012. http://dx.doi.org/10.1109/cspa.2012.6194771.

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Ismail, Nurlaila, Mohd Hezri Fazalul Rahiman, Rozita Jailani, Mohd Nasir Taib, Nor Azah Mohd Ali, and Saiful Nizam Tajuddin. "Investigation of common compounds in high grade and low grade Aquilaria Malaccensis using correlation analysis." In 2012 IEEE Control and System Graduate Research Colloquium (ICSGRC). IEEE, 2012. http://dx.doi.org/10.1109/icsgrc.2012.6287176.

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Batubara, Ridwanti, T. Ismanelly Hanum, Iwan Risnasari, Herawaty Ginting, and Lusi Amelia Lubis. "Antioxidant Activity and Preferences Test of Agarwood Leaves Tea (Aquilaria malaccensis Lamk) Based on Leaves Drying Methods." In Bromo Conference, Symposium on Natural Products and Biodiversity. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0008359101590163.

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Masita, Rahmi, Tri Rini Nuringtyas, Nastiti Wijayanti, and Lisna Hidayati. "Antiviral activity of agarwood Aquilaria malaccensis lamk and Gyrinops versteegii (Gilg.) Domke leaves ethanolic extract against dengue serotype 3 virus in vitro." In PROCEEDINGS OF THE 3RD INTERNATIONAL SEMINAR ON METALLURGY AND MATERIALS (ISMM2019): Exploring New Innovation in Metallurgy and Materials. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0002645.

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Wirjosentono, Basuki, Ridwanti Batubara, Tamrin, Urip Harahap, and Diana Adnanda Nasution. "Preparation and phytochemical characterisation of antioxidant active ethanol extract of agarwood (Aquilaria malaccensis Lamk) leaf (EEAL) using liquid chromatography-mass spectroscopy (LC-MS)." In THE INTERNATIONAL CONFERENCE ON CHEMICAL SCIENCE AND TECHNOLOGY (ICCST – 2020): Chemical Science and Technology Innovation for a Better Future. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0046396.

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Nuriliani, Ardaning, Deby Lukmawati, Veggy Fazari Ameliya, and Luthfi Nurhidayat. "Histopathological effects of ethanolic extract of Gaharu’s (Aquilaria malaccensis Lamk.) leaves on liver and kidney of mice (Mus musculus L.) infected by Plasmodium berghei." In THE 6TH INTERNATIONAL CONFERENCE ON BIOLOGICAL SCIENCE ICBS 2019: “Biodiversity as a Cornerstone for Embracing Future Humanity”. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0015770.

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