Relevant bibliographies by topics / AR147

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Academic literature on the topic 'AR147'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 February 2022

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Journal articles on the topic "AR147"

1

Hammerschick, Tim, Tim Wagner, and Walter Vetter. "Countercurrent chromatographic fractionation followed by gas chromatography/mass spectrometry identification of alkylresorcinols in rye." Analytical and Bioanalytical Chemistry 412, no. 30 (2020): 8417–30. http://dx.doi.org/10.1007/s00216-020-02980-3.

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AbstractAlkylresorcinols (5-alkyl-1,3-dihydroxybenzenes, ARs) are bioactive phenolic lipid compounds which are particularly abundant in rye and partly other cereals. In this study on ARs, whole rye grain extracts were gained with cyclohexane/ethyl acetate (46/54, w/w). Silylated extracts were used to develop a gas chromatography with mass spectrometry method in the selected ion monitoring mode (GC/MS-SIM) for the sensitive detection of conventional ARs along with keto-substituted (oxo-AR) and ring-methylated ARs (mAR) with 5-alkyl chain lengths of 14 to 27 carbon atoms and 0 to 4 double bonds in one run. Analysis was performed by countercurrent chromatographic (CCC) fractionation using the solvent system n-hexane/ethyl acetate/methanol/water (9/1/9/1, v/v/v/v). Subsequent GC/MS-(SIM) analysis of 80 silylated CCC fractions enabled the detection of 74 ARs in the sample. The CCC elution of the ARs followed the equivalent chain length (ECL) rule in which one double bond compensated the effect of two (additional) carbon atoms. Novel or rarely reported ARs were detected in virtually all classes, i.e. saturated AR (AR14:0), even-numbered monounsaturated AR isomers (AR16:1-AR26:1), triunsaturated ARs (AR25:3), oxo-ARs (AR17:0 oxo, AR19:1 oxo, AR21:2 oxo, AR23:2 oxo) and odd-numbered methyl-ARs (mAR15:0-mAR23:0). Positions of the double bonds of monounsaturated ARs and oxo-ARs were determined with the help of dimethyl disulfide (DMDS) derivatives.
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2

Kidd, Bruce L., Richard M. Langford, and Theresa Wodehouse. "Arthritis and pain. Current approaches in the treatment of arthritic pain." Arthritis Research & Therapy 9, no. 3 (2007): 214. http://dx.doi.org/10.1186/ar2147.

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3

Fu, Yun-Chang, Hongshen Jiang, and Paul Bishop. "An Inhibition Study of the Effect of Azo Dyes on Bioactivity of Biofilms." Water Science and Technology 29, no. 7 (1994): 365–72. http://dx.doi.org/10.2166/wst.1994.0363.

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An inhibition study showed that toxic compounds caused two responses when present at low concentration. One is stimulation of the biomass by simply serving as an energy source; this caused an increase in the total respiration rate. The other is inhibition of the reaction. AR14 was more toxic than AO7 for biofilm from reactors fed with a primary substrate. However, AO7 demonstrated inhibition for biofilm from reactors fed with AR14 and primary substrate, and AR14 could serve as a carbon source for the same film.
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4

Sheppard, Ryan L., Espen E. Spangenburg, Eva R. Chin, and Stephen M. Roth. "Androgen receptor polyglutamine repeat length affects receptor activity and C2C12 cell development." Physiological Genomics 43, no. 20 (2011): 1135–43. http://dx.doi.org/10.1152/physiolgenomics.00049.2011.

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Testosterone (T) has an anabolic effect on skeletal muscle and is believed to exert its local effects via the androgen receptor (AR). The AR harbors a polymorphic stretch of glutamine repeats demonstrated to inversely affect receptor transcriptional activity in prostate and kidney cells. The effects of AR glutamine repeat length on skeletal muscle are unknown. In this study we examined the effect of AR CAG repeat length on AR function in C2C12 cells. AR expression vectors harboring 14, 24, and 33 CAG repeats were used to assess AR transcriptional activity. C2C12 cell proliferation, differentiation, gene expression, myotube formation, and myonuclear fusion index were assessed. Transcriptional activity increased with increasing repeat length and in response to testosterone (AR14 = 3.91 ± 0.26, AR24 = 25.21 ± 1.72, AR33 = 36.08 ± 3.22 relative light units; P < 0.001). Ligand activation was increased for AR33 (2.10 ± 0.04) compared with AR14 (1.54 ± 0.09) and AR24 (1.57 ± 0.05, P < 0.001). AR mRNA expression was elevated in each stably transfected line. AR33 cell proliferation (20,512.3 ± 1,024.0) was decreased vs. AR14 (27,604.17 ± 1,425.3; P < 0.001) after 72 h. Decreased CK activity in AR14 cells (54.9 ± 2.9 units/μg protein) in comparison to AR33 (70.8 ± 8.1) ( P < 0.05) was noted. The myonuclear fusion index was lower for AR14 (15.21 ± 3.24%) and AR33 (9.97 ± 3.14%) in comparison to WT (35.07 ± 5.60%, P < 0.001). AR14 and AR33 cells also displayed atypical myotube morphology. RT-PCR revealed genotype differences in myostatin and myogenin expression. We conclude that AR polyglutamine repeat length is directly associated with transcriptional activity and alters the growth and development of C2C12 cells. This polymorphism may contribute to the heritability of muscle mass in humans.
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5

Behnajady, Mohammad A., and Mahsa Hajiahmadi. "Intensification of Azo Dye Removal Rate in the Presence of Immobilized Nanoparticles and Inorganic Anions under UV-C Irradiation: Optimization by Response Surface Methodology." International Journal of Photoenergy 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/289290.

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Wastewaters contain inorganic anions that affect the removal rate of organic pollutants. The present study aims to optimize the effects of inorganic anions such as , Cl−, , and on the removal rate of an organic pollutant in the presence of immobilized TiO2nanoparticles using response surface methodology (RSM). C.I. Acid Red 17 (AR17) was used as a model organic pollutant. Thirty experiments were required to study the effects of anions in various concentrations. The results indicate that the addition of and ions intensifies the removal rate of AR17. The results of the analysis of variance (ANOVA) showed a high coefficient of determination value ( and ). The results indicate that RSM is a suitable method for modeling and optimizing the process. The results prove that in the presence of and and ions especially in the combination situation the removal rate of AR17 is enhanced considerably. An important synergy effect was observed in the combination of and ions, so that AR17 removal percent under the optimized RSM conditions was considerably more than the sum of removal percent when these ions are used individually.
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6

Shojaat, Rahim, Afzal Karimi, Naghi Saadatjoo, and Soheil Aber. "Dye removal from artificial wastewater using heterogeneous bio-fenton system." Chemical Industry and Chemical Engineering Quarterly 23, no. 4 (2017): 447–56. http://dx.doi.org/10.2298/ciceq160621058s.

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In the present study, GOx/MnFe2O4/calcium alginate nano-composite was prepared by the trapping enzyme/nanoparticles in calcium alginate. The prepared absorbent was applied for decolorization of artificial dye wastewater of acid red 14 (AR14) by heterogeneous bio-Fenton system. Kinetic and isotherm studies were carried out. The decolorization of acid red 14 followed the Michaelis- Menten, pseudo-first order and pseudo-second order kinetic models. Good correlation coefficients were obtained by fitting the experimental data to Michaelis- Menten and pseudo-second order kinetic models. The adsorption isotherms were described by Langmuir, Freundlich and Temkin isotherms. Among the three isotherm models, the Freundlich model was fitted with the equilibrium data obtained from adsorption of AR14 onto MnFe2O4/calcium alginate; while Temkin isotherm gave the best correlation for adsorption on MnFe2O4 nanoparticles. The effect of various parameters such as initial pH of solution, initial dye concentration, and contact time on the adsorption of AR14 on MnFe2O4 and MnFe2O4/ /calcium alginate as well as dye enzymatic decomposition was studied. The decolorization of AR14 with initial concentration of 10 mg.L?1 by using GOx/ /MnFe2O4/calcium alginate was 60.17%.
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7

Yang, Z. H., X. M. Chen, Y. P. Zhang, et al. "X-Ray Spectra of Hydrogen-Like and Helium-Like Argon Ions on Solid Surfaces." Solid State Phenomena 121-123 (March 2007): 995–98. http://dx.doi.org/10.4028/www.scientific.net/ssp.121-123.995.

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14-GHz electron cyclotron resonance ion source at the Heavy Ion Research Facility National Laboratory in Lanzhou has been used to investigate x-rays from the interaction of slow highly charged Ar17+and Ar16+ions for different energies with Be, Al, Ni, Mo and Au surfaces. Interaction of Ar17+ and Ar16+ ions with Metallic Surfaces for a wide range of energies has been studied by measuring the resulting x-ray emission. The characteristic features of the x-ray spectra have been explained.
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8

Freund, Monique, Jean-Pierre Cazenave, Michael Courtney, et al. "Inhibition by Recombinant Hirudins of Experimental Venous Thrombosis and Disseminated Intravascular Coagulation Induced by Tissue Factor in Rats." Thrombosis and Haemostasis 63, no. 02 (1990): 187–92. http://dx.doi.org/10.1055/s-0038-1645193.

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SummaryAntithrombotic potency of recombinant hirudins rHV2, rHV2–Lys47 and rHV2–Arg47 was studied in a model of experimental thrombosis induced by tissue factor in the rat. Venous thrombosis was induced by i.v. injection of 25 mg/kg tissue factor followed by stasis of the inferior vena cava. In this model natural recombinant hirudins, rHV2 and rHV2–Lys47 injected 5 min before thromboplastin totally inhibited thrombosis in the same μg range as heparin or natural hirudin extracted from leeches. However, the mutant variant rHV2–Arg47 gave a maximal 60% inhibition of thrombosis. Variants rHV2–Lys47 (30 μg/kg) and rHV2–Arg47 (157 μg/kg) injected 5 min before thromboplastin prevented by 90 to 100% the drop in platelet count observed during the disseminated intravascular coagulation induced by thromboplastin injection. Recombinant hirudins were less anticoagulant than heparin as measured by an APTT on rat plasma. After rat tail transection, rHV2–Lys47 caused a 2–fold smaller prolongation of the bleeding time than an equivalent antithrombotic dose of heparin. Plasmatic elimination of rHV2–Lys47 from rat plasma after i.v. injection had a fast distribution phase with a half-life of 3 min during which 90% of injected rHV2–Lys47 was lost and was followed by a slower elimination phase. Thus recombinant hirudin rHV2–Lys47 appears as a promising potent antithrombotic agent for the prevention of thrombin-dependent venous thrombosis and disseminated intravascular coagulation
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9

Ma, Wei, Gloria Fuentes, Xiaohe Shi, Chandra Verma, George K. Radda, and Weiping Han. "FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3." Biochemical Journal 466, no. 2 (2015): 291–98. http://dx.doi.org/10.1042/bj20141109.

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The amino acid region Gly140–Leu160 (key residues Gln145, Arg147, Lys148, Arg153 and Arg154) of FoxO1 is identified as a STAT3 binding site, which is critical for FoxO1 to inhibit STAT3-mediated leptin-induced POMC activation.
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10

Pfoh, Roland, Emil F. Pai, and Vivian Saridakis. "Nicotinamide mononucleotide adenylyltransferase displays alternate binding modes for nicotinamide nucleotides." Acta Crystallographica Section D Biological Crystallography 71, no. 10 (2015): 2032–39. http://dx.doi.org/10.1107/s1399004715015497.

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Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the biosynthesis of NAD+and NaAD+. The crystal structure of NMNAT fromMethanobacterium thermoautotrophicumcomplexed with NAD+and SO42−revealed the active-site residues involved in binding and catalysis. Site-directed mutagenesis was used to further characterize the roles played by several of these residues. Arg11 and Arg136 were implicated in binding the phosphate groups of the ATP substrate. Both of these residues were mutated to lysine individually. Arg47 does not interact with either NMN or ATP substrates directly, but was deemed to play a role in binding as it is proximal to Arg11 and Arg136. Arg47 was mutated to lysine and glutamic acid. Surprisingly, when expressed inEscherichia coliall of these NMNAT mutants trapped a molecule of NADP+in their active sites. This NADP+was bound in a conformation that was quite different from that displayed by NAD+in the native enzyme complex. When NADP+was co-crystallized with wild-type NMNAT, the same structural arrangement was observed. These studies revealed a different conformation of NADP+in the active site of NMNAT, indicating plasticity of the active site.
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