Academic literature on the topic 'Arctium'
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Journal articles on the topic "Arctium"
Skowrońska, Weronika, Sebastian Granica, Magdalena Dziedzic, Justyna Kurkowiak, Maria Ziaja, and Agnieszka Bazylko. "Arctium lappa and Arctium tomentosum, Sources of Arctii radix: Comparison of Anti-Lipoxygenase and Antioxidant Activity as well as the Chemical Composition of Extracts from Aerial Parts and from Roots." Plants 10, no. 1 (January 2, 2021): 78. http://dx.doi.org/10.3390/plants10010078.
Full textOproshanska, Tetiana V., and Olga P. Khvorost. "Determination of the quantitative content of some groups of phenolic compounds in tinctures from the raw material of plant families Polygonaceae, Rosaceae, Asteraceae." Journal of Organic and Pharmaceutical Chemistry 19, no. 4(76) (December 23, 2021): 54–59. http://dx.doi.org/10.24959/ophcj.21.244365.
Full textJeelani, S., and M. A. Khuroo. "Triterpenoids from Arctium lappa." Natural Product Research 26, no. 7 (August 18, 2011): 654–58. http://dx.doi.org/10.1080/14786419.2010.541886.
Full textLeontyeva, Irina Aleksandrovna. "The study of burdock blossoms (Asteraceae: Arctium) entomofauna in the Yelabuga District of the Republic of Tatarstan." Samara Journal of Science 6, no. 4 (December 1, 2017): 53–57. http://dx.doi.org/10.17816/snv201764110.
Full textOproshanska, T., and O. Khvorost. "Potentiometric determination of organic acids in the medicinal plant raw material." News of Pharmacy, no. 1(101) (February 1, 2021): 11–17. http://dx.doi.org/10.24959/nphj.21.42.
Full textДьякова (Dyakova), Нина (Nina) Алексеевна (Аlekseevna). "DEVELOPMENT AND VALIDATION OF THE EXPRESS TECHNIQUE OF ALLOCATION AND QUANTITATIVE DEFINITION OF WATER-SOLUBLE POLYSACCHARIDES OF LEAVES OF ARCTIUM LAPPA L." chemistry of plant raw material, no. 4 (December 11, 2018): 81–87. http://dx.doi.org/10.14258/jcprm.2018042195.
Full textGhedira, K., and P. Goetz. "Arctium lappa L. (Asteraceae) : Bardane." Phytothérapie 11, no. 6 (December 2013): 376–80. http://dx.doi.org/10.1007/s10298-013-0827-1.
Full textTurdumambetov, K., G. A. Bakirov, and D. A. Rakhimov. "Glucofructans from Arctium tomentosum Roots." Chemistry of Natural Compounds 40, no. 3 (May 2004): 211–14. http://dx.doi.org/10.1023/b:conc.0000039125.29910.a1.
Full textLi, Jin, Chong Deng, Peng Zhao, Na Wang, and Lu Wang. "Kinetics on the Leaching of Polyphenol from Arctium lappal Root." Advanced Materials Research 586 (November 2012): 235–38. http://dx.doi.org/10.4028/www.scientific.net/amr.586.235.
Full textWu, Jian-Guo, Jin-Zhong Wu, Lian-Na Sun, Ting Han, Jian Du, Qi Ye, Hong Zhang, and Yu-Guang Zhang. "Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats." Phytomedicine 16, no. 11 (November 2009): 1033–41. http://dx.doi.org/10.1016/j.phymed.2009.04.005.
Full textDissertations / Theses on the topic "Arctium"
Saço, Luana Carla. "Avaliação do potencial esquistossomicida da arctiina, extraída de Arctium lappa L." Universidade Federal de Juiz de Fora (UFJF), 2015. https://repositorio.ufjf.br/jspui/handle/ufjf/3116.
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CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
A esquistossomíase é considerada uma das doenças tropicais negligenciada mais significativa no mundo. Sendo que a presença de apenas um medicamento para o tratamento da infecção leva a busca por novos compostos esquistossomicidas, utilizando os produtos naturais como uma das principais fontes destas novas moléculas. Neste sentido, a lignana Arctiina extraída da espécie Arctium lappa, cujas funções anti-inflamatórias e antiproliferativas já foram descritas na literatura, se tornou alvo do nosso estudo. O nosso propósito foi pesquisar a sua ação esquistossomicida através de testes in vitro e em modelo murino. A substância foi utilizada nas concentrações de 30, 60, 120 e 240 µg/mL nos ensaios in vitro. Após o período de incubação, em nenhuma das concentrações, a molécula foi capaz de promover modificação na viabilidade do parasito em cultura quando comparado ao grupo controle. Após a administração por via intraperitoneal, para verificar a presença da substância no plasma murino, foi realizada uma análise cromatográfica. A análise da amostra de arctiina pura, diluída em metanol, e diluída em plasma murino não tratado mostrou um pico no cromatograma medido a 254 nm, com retenção de 5 minutos. A amostra de plasma animal coletada após uma hora de tratamento com arctiina, sob as mesmas condições experimentais, revelou um pico semelhante ao da amostra pura, confirmando que a arctiina está disponível no plasma após administração. Os testes in vivo, foram realizados em camundongos fêmeas da linhagem Swiis que receberam por via intraperitoneal duas dosagens de arctiina (50 mg/kg), sendo a primeira administrada 20 dias após a infecção e a segunda após duas semanas. Nos parâmetros analisados: peso hepático, leucometria global, redução da carga parasitária e alteração no oograma, não foi verificado nenhuma alteração significativa em relação aos parâmetros encontrados no grupo controle infectado, tratado com praziquantel (200 mg/kg) e Dimetilsulfóxido (0,5%). O resultado mais promissor foi uma redução das médias das áreas dos granulomas, a administração da arctiina provocou uma redução em torno de 20% em comparação com o controle infectado. Mais estudos devem ser realizados a fim de verificar o possível mecanismo de atuação sobre os componentes inflamatórios presentes na formação do granuloma.
Schistosomiasis is one of the most significant neglected tropical diseases in the world. Only one drug is currently available for the treatment and control of schistosomiasis, therefore there is an urgent need for the development of new schistosomicide compounds, being natural products an important source of these molecules. Hence, in this work we studied the lignan arctiin extracted from Arctium lappa species, whose anti-inflammatory and antiproliferative functions have been previously described. Our aim was to investigate in vitro and in vivo its schistosomicidal activity. We tested the compound in vitro at the follow concentrations 30, 60, 120 and 240 ug/ml. There was no difference in all tested concentrations in the viability of the parasite in the culture after the incubation when compared to the control group. In addition we verified the plasmatic concentration of arctiin after intraperitoneal administration in mice by chromatographic analysis. The analysis of pure arctiin diluted in either methanol or mouse plasma showed a peak in the chromatogram at retention time of 5 minutes, absorbance was measured at 254 nm. Animal plasma sample collected one hour after treatment with arctiin was analyzed under same experimental conditions and revealed a similar peak, confirming the availability of arctiin in the plasma following administration. The in vivo tests were performed in Swiss female mice, those were intraperitoneally injected with two dosages of arctiin (50 mg/kg) - the first administered 20 days after infection and the second two weeks later. The follow parameters were analyzed: liver weight, white blood cell count, parasitic load and oogram. We did not find any significant change in those parameters comparing infected control groups treated either with praziquantel (200 mg / kg) or dimethyl sulfoxide (0.5 %) to the group treated with arctiin. The most promising result was the reduction around 20% of the average area of the granuloma in the arctiin group compared with the infected control. More studies are needed to verify possible mechanisms of action of this molecule in inflammatory components that play a role in granuloma formation.
López, Viñallonga Sara. "Evolució, filogènia i sistemàtica del complex "Arctium-Cousinia"." Doctoral thesis, Universitat de Barcelona, 2009. http://hdl.handle.net/10803/961.
Full textLa filogènia generada al present treball, confirma la monofilia del complex Arctium-Cousinia així com la seva subdivisió en dos llinatges també monofilètics anomenats Arctioide i Cousinioide. Al seu torn posa de manifest la manca de monofilia dels gèneres Arctium i Cousinia i de Cousinia subgèneres Cynaroides i Hypacanthodes. La solució que es proposa és la redefinició del gènere Arctium al qual s'han transferit totes les espècies del llinatge Arctioide i s'han proposat els canvis nomenclaturals pertinents. Paral·lelament, mitjançant la tècnica del rellotge molecular, s'ha datat el complex Arctium-Cousinia en 19.1 ma, la separació dels llinatges Arctioide i Cousinioide en 14.8 ma i la diversificació dels esmentats llinatges en 9.7 ma i 8,7 ma, respectivament.
L'estudi sobre la genètica poblacional d'Arctium minus, realitzat mitjançant l'ús de microsatèl·lits dissenyats a aquest treball, ha mostrat que els patrons de variabilitat genètica de l'esmentada espècie són consistents amb les seves característiques biològiques: la seva capacitat d'autofecundació i el seu curt cicle de vida expliquen la seva baixa diversitat genètica, alts valors d'endogàmia i excés d'homozigots. La major part de la variabilitat genètica es troba entre poblacions a causa d'un baix flux gènic entre elles juntament amb la seva capacitat facultativa d'autofecundació. S'han detectat indicis de què A. Minus s'hauria refugiat al sud de la seva actual àrea de distribució durant les glaciacions del Pleistocè i posteriorment hauria recolonitzat Europa. Aquests patrons s'haurien vist emmascarats per influència recent de l'activitat humana i per esdeveniments de dispersió de llavors a llarga distància.
English summary:
This thesis is focused on the Arctium-Cousinia complex (Compositae, Cardueae-Carduinae), including Arctium L., Cousinia Cass. as one of the largest genera of the Compositae, Hypacanthium Juz. and Schmalhausenia C. Winkl. This group of genera has its highest diversity in the Irano-Turanian region and the mountains of Central Asia (Tien Shan and Pamir-Alaj). Arctium s.str. is Eurosiberian in distribution. Significant difficulties in generic delimitation in this complex arise from the incongruent distribution of several morphological, pollen, karyological and molecular characters.
The phylogeny obtained bears out the monophyly of the Arctium-Cousinia complex and its division in two monophyletic lineages named Arctioid and Cousinioid. Our analyses also show that Arctium and Cousinia as well as Cousinia subgenera Cynaroides and Hypacanthodes are not monophyletic. As a solution, a broadly monophyletic genus Arctium is proposed, including all the species belonging to the Arctioid lineage and we provide nomenclatural changes when necessary. In addition, using the molecular clock approach the Arctium-Cousinia complex is dated in 19.1 mya, the split of the Arctioid and Cousinioid lineages in 14.8 mya and the diversification of the lineages mentioned in 9.7 mya and 8,7 mya, respectively.
Regarding the population genetics of Arctium minus (Hill) Bernh., investigated using microsatellite markers developed for this study, the observed patterns of genetic variation are consistent with its life style. Low gene diversity, high inbreeding values and significant homozygote excess were recovered, factors linked with the self-pollination ability of A. minus and its short-life cycle. Most of the genetic variability is found among instead of within populations due to low gene flow altogether with its self-pollination ability. There are few signs which may suggest that A. minus adapted to the Pleistocene climatic changes in the European populations with putative refugia in the south of its present distribution from where the species might radiate northwards. It is also suggested that original biogeographic patterns in A. minus may have been blurred by human activity and by long distance seed dispersal.
This thesis is focused on the Arctium-Cousinia complex (Compositae, Cardueae-Carduinae), including Arctium L., Cousinia Cass. as one of the largest genera of the Compositae, Hypacanthium Juz. and Schmalhausenia C. Winkl. This group of genera has its highest diversity in the Irano-Turanian region and the mountains of Central Asia (Tien Shan and Pamir-Alaj). Arctium s.str. is Eurosiberian in distribution. Significant difficulties in generic delimitation in this complex arise from the incongruent distribution of several morphological, pollen, karyological and molecular characters.
The phylogeny obtained bears out the monophyly of the Arctium-Cousinia complex and its division in two monophyletic lineages named Arctioid and Cousinioid. Our analyses also show that Arctium and Cousinia as well as Cousinia subgenera Cynaroides and Hypacanthodes are not monophyletic. As a solution, a broadly monophyletic genus Arctium is proposed, including all the species belonging to the Arctioid lineage and we provide nomenclatural changes when necessary. In addition, using the molecular clock approach the Arctium-Cousinia complex is dated in 19.1 mya, the split of the Arctioid and Cousinioid lineages in 14.8 mya and the diversification of the lineages mentioned in 9.7 mya and 8,7 mya, respectively.
Regarding the population genetics of Arctium minus (Hill) Bernh., investigated using microsatellite markers developed for this study, the observed patterns of genetic variation are consistent with its life style. Low gene diversity, high inbreeding values and significant homozygote excess were recovered, factors linked with the self-pollination ability of A. minus and its short-life cycle. Most of the genetic variability is found among instead of within populations due to low gene flow altogether with its self-pollination ability. There are few signs which may suggest that A. minus adapted to the Pleistocene climatic changes in the European populations with putative refugia in the south of its present distribution from where the species might radiate northwards. It is also suggested that original biogeographic patterns in A. minus may have been blurred by human activity and by long distance seed dispersal.
Almeida, Ana Beatriz Albino de. "Atividade antiulcerogenica e antiinflamatoria intestinal da Arctium lappa." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/318126.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: Onodorpicrina, uma sesquiterpeno lactona, presente nas folhas de Arctium Lapa L. demonstrou através dos estudos de Barbosa et at (1993) erficaz atividade farmacológica. Com base nesses resultados e, devido ao fato, de nosso laboratório possuir estudos em relação à atividade antiulcerogênica de outras sesquiterpeno lactonas (desidrocrotonina e crotonina) obtidas das cascas de Croton cajucara Benth, decidimos estudar a atividade antiulcerogênica e antiinflamtória intestinal da fração semi-purificada (ONP), cujo composto majoritário é a onopordopicrina. Primeiramente estudamos o efeito da citotoxicidade da ONP avaliado através da viabilidade celular em fibroblastos (V79) de pulmão de Hamster chinês. A ONP apresentou IC50 aproximadamente de 15µM nos ensaios de MTT, vermelho neutro e conteúdo de ácido nucléico. Por ser uma substância com uma toxicidade relativa resolvemos estudar o efeito antitumoral dessa substância em linhagem celular de leucemia promielocítica (HL60) usada como modelo para estudos antitumorais. Da mesma forma que nos ensaios de citotoxidade, a ONP apresentou IC50 aproximadamente de 15 µM em ensaios de MTT e PTP. Para avaliar a atividade antiulcerogênica da ONP, foram utilizadas diferentes doses em modelos clássicos de indução de úlcera: etanol/HCl, estresse por imobilização e frio, indometacina e ligadura de piloro. Em todos os modelos a ONP apresentou atividade antiulcerogênica significativa. Nos procedimentos seguintes, avaliamos a atividade antisecretora da ONP através de ensaios de somatostatina e gastrina, nos quais a substância apresentou aumento da liberação e/ou produção de somatostatina e diminuição da produção e/ou liberação de gastrina. Em relação ao estudo da ONP em experimentos de muco e óxido nítrico, essa não apresentou diferença significativa. No entanto, promoveu diferença significativa no modelo de avaliação do envolvimento de radicais sulfidrila, indicando uma possível atividade antioxidante. Quando avaliada em modelo de colite ulcerativa induzida por TNBS, a ONP apresentou significativa proteção provavelmente pelo envolvimento da mieloperoxidase (MPO) e fator de necrose tumoral (TNF-alfa). Visto a atividade obtida com a ONP, resolvemos analisar a atividade do chá de Arctium lappa, o qual apresentou significativa envolvimento com óxido nítrico e grupamento sulfidrila para a obtenção da atividade antiulcerogência promovida pelo chá. Os resultados obtidos com a Arctium lappa são promissores, por causa de sua significativa proteção contra úlceras induzidas por diferentes agentes, sugerindo um efeito antisecretor mediado por sua ação na secreção de Somatostatina e Gastrina e um efeito protetor proporcionado pela propriedade antioxidante presente na ONP. Os dados também revelaram que o pré-tratamento com ONP é capaz de reduzir a inflamação intestinal produzida através do modelo de indução de colite ulcerativa por TNBS em ratos. O efeito agudo antiinflamatório provavelmente está relacionado com a diminuição de neutrófilos e diminuição da produção de TNF-a na mucosa intestinal. Nossos resultados sugerem um significativo potencial terapêutico da ONP na area gastrointestinal
Abstract: Onodorpicrin, a sesquiterpene lactone, present in the leaves of Arctium lappa L., showed through the studies of Barbosa et al (1993) effective pharmacological activity. Based on those results and due to the fact that our laboratory has studies in relation to the antiulcerogenic activity of other sesquiterpene lactone (dehydrocrotonin and crotonin) obtained by barks of Croton cajucara Benth, we decided to study the antiulcerogenic activity and bowel antiinflamatory of the semi-purified fraction (ONP), which majority compound is the onopordopicrin. Firstly we studied the effect of the citotoxicity of appraised ONP through the cellular viability in fibroblast (V79) of lung of Chinese Hamster. ONP presented IC50 approximately of 15µM in the MTT, red neutral and content of nucleic acid experiments. For being a substance with a relative toxicity we decided to study the effect antitumoral of that substance in cellular lineage of promyelocytic leukemia (HL60) used as model for antitumoral studies. In the same way that in the citotoxicity experiments, ONP presented IC50 approximately of 15 µM in experiments of MTT and PTP. To evaluate the antiulcerogenic activity of ONP, different doses were used in classic models of ulcer induction: ethanol/HCl, stress for immobilization and cold, indometacin and pylorus ligature. In all of the models ONP presented significant antiulcerogenic activity. In the following procedures, we evaluated the activity antisecretory of ONP through somatostatin and gastrin experiments, in which the substance presented increase of the liberation and/or somatostatin production and decrease of the liberation and/or gastrin production. In relation to the study of ONP in mucus experiments and nitric oxide, that one didn't present significant difference. However, it showed significant difference in the model of evaluation of the involvement of radicals sulphydryl, indicating a possible antioxidant activity. When evaluated in model of colitis ulcerative induced by TNBS, ONP presented significant protection probably for the involvement of the mieloperoxidase (MPO) and factor of necrosis tumoral (TNF-alpha). Checked the activity obtained with ONP, we decided to analyze the activity of the tea of Arctium lappa, which presented significant involvement with nitric oxide and sulphydryl group for the obtaining of the antiulcerogenic activity promoted by the tea. The results obtained with Arctium lappa are promising, because the significant protection against ulcers induced by different agents suggesting a effect antisecretory mediated through somatostatin and gastrin secretion and protective effect by the antioxidant properties present in ONP. The data also reveals that pre-treatment with ONP is able to reduce intestinal inflammation in theTNBS model of colitis in rats.The acute antiinflamatory effects seem to be related to impairment of neutrophil function and absence of up-regulation of TNF-a production in intestinal mucosa. Our findings suggest that ONP shows an excellent potential for therapy in the gastrointestinal area
Doutorado
Fisiologia
Doutor em Biologia Funcional e Molecular
Duistermaat, Helena. "Monograph of Arctium L.(Asteraceae) : generic delimitation (uncluding Cousinia Cass. p. p.), revision of the species, pollen morphology, and hybrids /." Leiden : Rijksherbarium, Hortus botanicus, Leiden university, 1996. http://catalogue.bnf.fr/ark:/12148/cb37560427k.
Full textCarlotto, Juliane. "Estudo químico e biológico de folhas de Arctium lappa." reponame:Repositório Institucional da UFPR, 2013. http://hdl.handle.net/1884/30619.
Full textHu, Bizhen. "Metabolite Production in Callus Culture of Burdock (Arctium lappa L.)." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1357141954.
Full textDias, Mirna Meana. "Avaliação da atividade esquistossomicida in vitro do extrato hidroalcoólico bruto e metabólitos secundários dos frutos da Arctium lappa L. (Asteraceae)." Universidade Federal de Juiz de Fora (UFJF), 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/5455.
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FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
A esquistossomíase, causada por parasitos do gênero Schistosoma, é uma doença que afeta cerca de 240 milhões de pessoas no mundo. O Praziquantel é o fármaco de escolha para o tratamento desta parasitose e, devido principalmente aos casos de resistência do parasito a esta medicamento, se faz necessária a busca de novas moléculas e/ou protótipos com potencial atividade esquistossomicida. Neste contexto, a pesquisa com produtos naturais desponta como uma alternativa para o descobrimento de novos fármacos para o tratamento da esquistossomíase. Entre as espécies vegetais de interesse para a produção de substâncias esquistossomicidas, destaca-se a Arctium lappa L. (Asteraceae), a qual é reconhecida por biossintetizar lignóides, classe de metabólitos que tem demonstrado grande potencial esquistossomicida. O presente trabalho descreve o estudo fitoquímico do extrato hidroalcoólico dos frutos de A. lappa, bem como a avaliação da atividade esquistossomicida in vitro, frente aos vermes adultos de S. mansoni, do extrato e de seus metabólitos majoritários. O estudo fitoquímico de A. lappa L. resultou no isolamento de duas lignanas dibenzilbutirolactônicas, a arctiina e arctigenina. A análise dos resultados de avaliação esquistossomicida obtidos demonstrou que o extrato hidroalcoólico bruto na concentração de 200 mg/mL apresentou expressiva atividade esquistossomicida in vitro, sendo capaz de provocar a morte de 100% dos parasitos em até 24 horas de incubação. A arctiina, metabólito majoritário purificado do extrato, foi capaz de matar e provocar lesões tegumentares em 100% dos vermes adultos. Os resultados obtidos sugerem que a atividade esquistossomicida in vitro demonstrada pelo extrato hidroalcoólico pode estar relacionada à presença da arctiina, corroborando com o potencial esquistossomicida in vitro das lignanas dibenzilbutirolactônicas, frente aos vermes adultos de S. mansoni.
Schistosomiasis caused by the Schistosoma parasite is a disease that affects about 240 million people around the world. Praziquantel is the chosen drug for the treatment of this parasitosis. It is imperative to search for new molecules and / or prototypes with potential schistosomicidal activity. This requirement is due to the tough performance of the parasite against this medicine. In this context, the research with natural products has been recognized as an alternative to discover new pharmacos for Schistosoma treatment. Arctium lappa L. (Asteraceae) stands out among vegetal plants of interest for the production of schistosomicidal substances. This is recognized for being able to biosynthesize lignoid, a kind of metabolite that has performed great schistosomicidal potential. This master thesis describes the phytochemical study of the hydroalcoholic extract from A. lappa L. fruit, as well the evaluation of the schistosomicidal activity evaluation in vitro, facing the adult worms of S. mansoni from the extract and from its majority metabolite. The phytochemical study of A. lappa L. resulted in the isolation of two dibenzyl butyrolactone lignan, a arctiin e arctigenin. The results obtained schistosomicidal evaluation showed that hydroalcoholic extract crude in concentration of 200 mg/mL showed significant antischistosomal activity in vitro and is capable of causing the death of the 100% of the parasites within 24 hours of incubation. The arctiin a major purified metabolite from the extract, was capable of killing by causing tegumentary lesions en 100% of the adult worms. The obtained results suggest that the schistosomicidal activity in vitro showed by the hydroalcoholic extract can be related to arctiin presence, supporting the potencial schistosomicidal in vitro of dibenzyl butyrolactone lignan, against the adult worms of S. mansoni.
Predes, Fabricia de Souza. "Efeito antioxidante da bardana (Arctium lappa) no testículo, epidídmo e fígado de ratos danificados pelo cádmio : bioquímica, morfometria e ultraestrutura." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317834.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: Cádmio (Cd) é um metal pesado associado a graves danos em vários órgãos, incluindo órgãos reprodutivos e fígado. Estudos farmacológicos indicam que Arctium lappa possue atividade hepatoprotetora, sequestradora de radicais livres e antiproliferativa. O objetivo deste trabalho foi avaliar: (1) as modificações nos túbulos seminíferos causadas por pequenas doses de Cd, (2) as propriedades antioxidantes de diferentes extratos de A. lappa, (3) a capacidade de A. lappa em atenuar os danos induzidos por cádmio no testículo, epidídimo e fígado. A capacidade sequestradora de radicais livres e quantidade de compostos fenólicos totais foram analisados nos extratos da raiz de A. lappa para determinação da capacidade antioxidante. A propriedade antiproliferativa in vitro de cada extrato foi avaliada em células tumorais. O extrato hidroetanólico apresentou alto rendimento e capacidade sequestradora de radicais livres, e juntamente com os diclorometânicos, maior teor de compostos fenólicos. Somente os extratos diclorometânicos apresentaram atividade antiproliferativa contra células tumorais. espectroscopia de massa revelou a presença dos compostos arctigenina, quercetina, ácido clorogênico e ácido caféico no extrato hidroetanólico. O extrato hidroetanólico liofilizado foi escolhido para os estudos in vivo. Para estudar os efeitos de Cd e A. lappa, ratos Wistar adultos foram distribuídos em quatro grupos: controle (C), extrato de A. lappa (Al), cádmio (Cd) e cádmio e extrato de Al (CdAl). Os animais receberam água ou extrato de Al (300 mg/Kg BW) por gavagem e dose única i.p. de salina ou 1,2 mg/kg de cloreto de cádmio. Os animais foram sacrificados após 7 e 56 dias. O Cd causou redução do peso do testículo, epidídimo e vesícula seminal, na proporção dos túbulos seminíferos (TS), no comprimento total dos TS e no diâmetro dos TS. Células germinativas degeneradas e células gigantes multinucleadas foram observadas nos TS e os danos progressivos resultaram em túbulos preenchidos apenas com células de Sertoli. Nos grupos Cd e CdAl, houve diminuição da proporção tubular e aumento da altura do epitélio no epidídimo após 56 dias. Cd causou aumento no nível plasmático de TGO e TGP após 56 dias, mas o extrato de A. lappa amenizou estes efeitos. Nenhuma alteração relevante foi observada para as transaminases hepáticas. No grupo Cd 7 dias, a proporção de hepatócitos diminuiu, a de sinusóides aumentou e o número de núcleo de hepatócito reduziu, entretanto após 56 apenas o número de núcleos de hepatócitos diminuíram. Após 7 dias, nos grupos Al e CdAl, a proporção nuclear aumentou e a citoplasmática diminuiu, sem alteração dos capilares sinusóides. Após 56 dias, nos grupos Al e CdAl, a proporção nuclear aumentou e a proporção dos capilares sinusóides reduziu. Houve aumento na densidade de núcleos nos grupos Al e CdAl. Conclui-se que doses baixas de Cd causam alterações morfológicas e morfométricas no testículo e que o Cd tem sutil limiar tóxico. Os extratos diclorometânicos apresentaram atividade antiproliferativa contra as linhagens tumorais K562, MCF-7 e 786-0. O extrato hidroetanólico apresentou alto conteúdo fenólico e atividade antioxidante, portanto foi escolhido para os estudos in vivo. O extrato de A. lappa foi ineficaz na proteção do testículo e epidídimo contra danos induzidos pelo Cd, porém protegeu o tecido hepático.
Abstract: Cadmium (Cd) is a heavy metal associated with severe damage in various organs, including male reproductive organs and liver. Arctium lappa is widely used in popular medicine for treating hypertension, gout, hepatitis and other inflammatory disorders. Pharmacological studies indicated that A. lappa roots have hepatoprotective, free radical scavenging and antiproliferative activities. The objectives of this work were evaluate: (1) histomorphometrically the threshold modifications of seminiferous tubules caused by single acute low doses of Cd, (2) antioxidant properties of different A. lappa extracts to choose the best one for "in vivo" study, (3) the ability of A. lappa to attenuate cadmium-induced damage to the testis, epididymis and liver of male rats. Dichloromethanic, ethanolic, aqueous extracts, hydroethanolic and total aqueous extract of A. lappa roots were investigated regarding radical scavenging activity and the total phenolic content. The extracts were tested for their antiproliferative activity in vitro using human cancer cell lines. The higher radical scavenging activity and yield were found in the hydroethanolic extract. Higher phenolic contents were found in the dichloromethanic and hydroethanolic extracts. Only the dichloromethanic extracts exhibited activity against cancer cell lines. Highresolution electrospray ionization mass spectroscopy for the hydroethanolic extract demonstrated the presence of: arctigenin, quercetin, chlorogenic acid and caffeic acid. The hydroalcoholic lyophilized extract was chosen for the experiments in vivo. To study the association of Cd and A. lappa, adult Wistar rats were assigned to four groups: control (C), A.lappa extract (Al), cadmium (Cd) and cadmium plus A. lappa (CdAl). The animals received water or A. lappa hydroethanolic extract (300 mg/Kg BW) by gavage and i.p. injections of saline or 1.2 mg/Kg BW of cadmium chloride. The animals were sacrificed after 7 and 56 days of treatment. The Cd caused reduction in testis, epididymis and seminal vesicle weights, seminiferous tubule (ST) proportion, total length of ST and ST diameter. Degenerated germ cells and multinucleated aggregates were observed in ST and progressive damage resulted in tubules lined only with Sertoli cells. There was a decreased in tubular proportion and increased epithelial height in epididymis after 56 days. Cd caused an increase in plasma GOT and GPT levels after 56 days, but A. lappa extract improved these levels. No relevant alteration was observed in liver transaminase levels. After 7 days, the Cd group showed decrease in hepatocyte proportion and increase sinusoid capillary proportion, also the nuclear density decrease. However, after 56 days, only the hepatocyte nuclear density decreased. In Al and CdAl groups, after 7 days, the hepatocyte nuclear proportion increased and the cytoplasmic decreased, with no alteration in capillary sinusoid proportion. In Al and CdAl groups, after 56 days, hepatocyte nuclear proportion increased and the sinusoid capillary proportion decreased. Also, an increase of hepatocyte nuclear density was observed in Al and CdAl groups. This study revealed that low doses of Cd cause progressive morphological and morphometrical alterations on rat testis and that Cd has a subtle toxic threshold. The dichloromethanic extracts showed antiproliferative activity against K562, MCF-7 and 786-0 human cancer cell lines. The hydroethanolic extract showed higher free radical scavenger activity and higher phenolic content, and was chosen as the best extract for the "in vivo" studies. A. lappa hydroethanolic extract was ineffective in protecting the testis and epididymis against Cd-induced damage, however effectively protected liver tissue.
Doutorado
Biologia Celular
Mestre em Biologia Celular e Estrutural
Robbins, Lisa Renee. "Natural Variability in Phenolic and Sesquiterpene Constituents Among Burdock (Arctium lappa L. and Arctium minus L.) Leaves for Potential Medicinal Interests." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366117332.
Full textZhao, Jinlian. "Phytochemical and antibacterial studies on Arctium lappa, Tussilago farfara and Verbascum thapsus." Thesis, University of Strathclyde, 2014. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=23623.
Full textBooks on the topic "Arctium"
Norbert, Rosing, ed. Arctic fox: Life at the top of the world. Buffalo, New York: Firefly Books, 2008.
Find full textHavens, Alan C. Enhancement evaluation techniques for Arctic grayling (Thymallus arcticus) in Alaska, 1986. Juneau, Alaska: Alaska Dept. of Fish and Game, Division of Sport Fish, 1987.
Find full textTimchenko, L. D. Quo vadis, arcticum?: The international law regime of the Arctic and trends in its development. Kharkiv: State University Press "Osnova", 1996.
Find full text1940-, Oliver Tony, ed. Arctic odyssey: Travelling Arctic Europe. Swindon, Wiltshire: Crowood Press, 1991.
Find full textBook chapters on the topic "Arctium"
De Smet, P. A. G. M. "Arctium Species." In Adverse Effects of Herbal Drugs 2, 141–46. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-48906-8_9.
Full textBährle-Rapp, Marina. "Arctium lappa." In Springer Lexikon Kosmetik und Körperpflege, 44. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_775.
Full textBährle-Rapp, Marina. "Arctium majus." In Springer Lexikon Kosmetik und Körperpflege, 44. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_776.
Full textBährle-Rapp, Marina. "Arctium Tomentosum." In Springer Lexikon Kosmetik und Körperpflege, 44. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_778.
Full textLim, T. K. "Arctium lappa." In Edible Medicinal and Non Medicinal Plants, 655–86. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9511-1_20.
Full textKhare, C. P. "Arctium lappa Linn." In Indian Medicinal Plants, 1. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_142.
Full textBussmann, Rainer W., Ketevan Batsatsashvili, Zaal Kikvidze, Narel Y. Paniagua-Zambrana, Manana Khutsishvili, Inesa Maisaia, Shalva Sikharulidze, and David Tchelidze. "Arctium lappa L.Asteraceae." In Ethnobotany of Mountain Regions, 1–8. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-77088-8_14-2.
Full textBährle-Rapp, Marina. "Arctium Minus Extract." In Springer Lexikon Kosmetik und Körperpflege, 44. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_777.
Full textSastry, K. Subramanya, Bikash Mandal, John Hammond, S. W. Scott, and R. W. Briddon. "Arctium lappa (Greater burdock)." In Encyclopedia of Plant Viruses and Viroids, 184–86. New Delhi: Springer India, 2019. http://dx.doi.org/10.1007/978-81-322-3912-3_77.
Full textSastry, K. Subramanya, Bikash Mandal, John Hammond, S. W. Scott, and R. W. Briddon. "Arctium tomentosum (Woolly burdock)." In Encyclopedia of Plant Viruses and Viroids, 186–88. New Delhi: Springer India, 2019. http://dx.doi.org/10.1007/978-81-322-3912-3_78.
Full textConference papers on the topic "Arctium"
Лемясева, С. В., А. Н. Бабенко, and О. С. Кузина. "STUDY OF THE GENERAL TOXIC EFFECT OF ARCTIUM LAPPA L. LEAVES JUICE." In ОТ БИОХИМИИ РАСТЕНИЙ К БИОХИМИИ ЧЕЛОВЕКА. Москва: Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский институт лекарственных и ароматических растений", 2022. http://dx.doi.org/10.52101/9785870191041_376.
Full text"Volatile Oil Composition of Burdock Root (Arctium lappa L.) in Response to Mineral Fertilizer Application." In Mar. 17-18, 2022 Johannesburg (South Africa). International Institute of Chemical, Biological & Environmental Engineering, 2022. http://dx.doi.org/10.17758/iicbe3.c0322255.
Full text"Growth, Yield and Phytochemical Constituents of Arctium lappa L. in Response to Phosphorous and Potassium Fertilizers Application." In Nov. 16-17, 2020 Johannesburg (SA). Eminent Association of Pioneers, 2020. http://dx.doi.org/10.17758/eares10.eap1120122.
Full textKOLBINA, Anastasia Y., Marina G. KURBANOVA, and Roman A. VOROSHILIN. "Prospects for the Use of Arctium Lappa L Extract in the Production of Candy Caramel for Diabetic Nutrition." In IV International Scientific and Practical Conference "Modern S&T Equipments and Problems in Agriculture". Sibac, 2020. http://dx.doi.org/10.32743/kuz.mepa.2020.108-115.
Full textMANTOVANI CELEGATTI, CAROLINE, Maria Teresa Pedrosa Silva Clerici, and Thaísa Menezes Alves Moro. "Burdock root (Arctium lappa, L.) flours produced by air conventional drying and freeze-drying and its application in cookies." In XXIV Congresso de Iniciação Científica da UNICAMP - 2016. Campinas - SP, Brazil: Galoa, 2016. http://dx.doi.org/10.19146/pibic-2016-51453.
Full textMakarov, S. S., and A. I. Chudetsky. "THE USE OF VITAMIN-MINERAL COMPLEX AND BIOLOGICAL PREPARATIONS IN THE CULTIVATION OF THE ARCTIC BRAMBLE (RUBUS ARCTICUS L.)." In 90 лет - от растения до лекарственного препарата: достижения и перспективы. Москва: Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский институт лекарственных и ароматических растений", 2021. http://dx.doi.org/10.52101/9785870191003_2021_301.
Full textSouza, Alan, Viviane Moreira, and Carlos Heuser. "ARCTIC." In the 2014 ACM symposium. New York, New York, USA: ACM Press, 2014. http://dx.doi.org/10.1145/2644866.2644872.
Full textBain, Matthew. "Arctic fracture." In ACM SIGGRAPH 2008 posters. New York, New York, USA: ACM Press, 2008. http://dx.doi.org/10.1145/1400885.1401014.
Full textXie, Feng, Mike Necci, Jon Lanz, Patrick O'Brien, Paolo de Guzman, and Eduardo Bustillo. "Arctic ice." In the Fourth Symposium. New York, New York, USA: ACM Press, 2014. http://dx.doi.org/10.1145/2633374.2642654.
Full text"High Arctic." In Planet Austria. Wien: Verlag der Österreichischen Akademie der Wissenschaften, 2009. http://dx.doi.org/10.1553/planetaustrias258.
Full textReports on the topic "Arctium"
Pobedonosceva, Veronika, and Galina Pobedonosceva. SUPPORT ZONES AS THE BASIS OF RUSSIAN POLICY IN ITS ARCTIC ZONE. Science and Innovation Center Publishing House, 2020. http://dx.doi.org/10.12731/2070-7568-2020-2-3-132-143.
Full textБаттахов, Петр Петрович. ПРАВОВОЕ РЕГУЛИРОВАНИЕ СОЦИАЛЬНО-ЭКОНОМИЧЕСКИХ ОТНОШЕНИЙ В АРКТИЧЕСКОЙ ЗОНЕ. DOI CODE, 2021. http://dx.doi.org/10.18411/1815-1337-2021-11862.
Full textPOBEDONOSTSEVA, G., and V. POBEDONOSTSEVA. ABOUT THE ECONOMY SECURITY INDICATORS OF THE ARCTIC REGIONS OF RUSSIA. Science and Innovation Center Publishing House, 2021. http://dx.doi.org/10.12731/2070-7568-2021-10-5-2-172-180.
Full textTanis, Fred J. Arctic Optical. Fort Belvoir, VA: Defense Technical Information Center, September 1992. http://dx.doi.org/10.21236/ada258654.
Full textBradley, Douglas A. Forging an Arctic Alliance: Canadian-U.S. JIATF-Arctic. Fort Belvoir, VA: Defense Technical Information Center, October 2010. http://dx.doi.org/10.21236/ada535574.
Full textVilks, G. 14th Arctic Workshop: Arctic Land-Sea Interaction Abstracts. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1985. http://dx.doi.org/10.4095/130024.
Full textSackinger, W. M., M. O. Jeffries, M. C. Lu, and F. C. Li. Arctic ice islands. Office of Scientific and Technical Information (OSTI), January 1988. http://dx.doi.org/10.2172/6091444.
Full textShuchman, R. A., R. G. Onstott, and C. C. Wackerman. Arctic Ice Studies. Fort Belvoir, VA: Defense Technical Information Center, February 1993. http://dx.doi.org/10.21236/ada268608.
Full textLarsen, Joan Nymand, and Gail Fondahl. Arctic Human Development Report. Nordic Council of Ministers, February 2015. http://dx.doi.org/10.6027/tn2014-567.
Full textRusina, Tamara. Map of Arctic Ocean. Edited by Nikolay Komedchikov and Aleksandr Khropov. Entsiklopediya, April 2015. http://dx.doi.org/10.15356/dm2015-12-02-15.
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