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Journal articles on the topic 'Arctium'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 September 2022

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1

Skowrońska, Weronika, Sebastian Granica, Magdalena Dziedzic, Justyna Kurkowiak, Maria Ziaja, and Agnieszka Bazylko. "Arctium lappa and Arctium tomentosum, Sources of Arctii radix: Comparison of Anti-Lipoxygenase and Antioxidant Activity as well as the Chemical Composition of Extracts from Aerial Parts and from Roots." Plants 10, no. 1 (January 2, 2021): 78. http://dx.doi.org/10.3390/plants10010078.

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Arctium lappa is a weed used in traditional medicine in the treatment of skin inflammation and digestive tract diseases. Arctium tomentosum is used in folk medicine interchangeably with Arctium lappa and, according to European Medicines Agency (EMA) monography, provides an equal source of Arctii radix (Bardanae radix), despite the small amount of research confirming its activity and chemical composition. The aim of the study was the comparison of the anti-lipoxygenase and the antioxidant activity, scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion (O2•−), and hydrogen peroxide (H2O2), of 70 % (v/v) ethanolic extracts from the aerial parts and the roots of Arctium lappa and Arctium tomentosum. In the tested extracts, the total polyphenols content and the chemical composition, analyzed with the HPLC–DAD–MSn method, were also compared. The extracts were characterized by strong antioxidant properties, but their ability to inhibit lipoxygenase activity was rather weak. A correlation between the content of polyphenolic compounds and antioxidant activity was observed. The extracts from A. lappa plant materials scavenged reactive oxygen species more strongly than the extracts from A. tomentosum plant materials. Moreover, the extracts from A. lappa plant materials were characterized by the statistically significantly higher content of polyphenolic compounds.

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2

Oproshanska, Tetiana V., and Olga P. Khvorost. "Determination of the quantitative content of some groups of phenolic compounds in tinctures from the raw material of plant families Polygonaceae, Rosaceae, Asteraceae." Journal of Organic and Pharmaceutical Chemistry 19, no. 4(76) (December 23, 2021): 54–59. http://dx.doi.org/10.24959/ophcj.21.244365.

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Aim. To determine the quantitative content of total polyphenols and the amount of hydroxycinnamic acids in the series of tinctures from rhizomes with roots of Rumex confertus Willd., Sanguisorba officinalis L., roots of Rosa majalis Herrm., Rosa canina L., Arctium lappa L., Arctium minus (Hill) Bernh., Arctium tomentosum Mill., and the herb of Bidens tripartita L.Materials and methods. As study objects the tinctures from rhizomes with roots of Rumex confertus, Sanguisorba officinalis, roots of Rosa majalis, Rosa canina, Arctium lappa, Arctium minus, Arctium tomentosum and the herb of Bidens tripartita were used. These tinctures were obtained by the method of maceration at room temperature and the ratio of 1 : 5 of the plant raw material/finished products; the extractant was 50 % ethyl alcohol. The quantitative content of total polyphenols and the amount of hydroxycinnamic acids was determined by spectrophotometry according to the methods of the State Pharmacopoeia of Ukraine.Results and discussion. The limits of the quantitative content of total polyphenols and the amount of hydroxycinnamic acids in the tinctures were determined. They were not less than 0.070 mg mL-1 and 0.002 mg mL-1 for the tincture of rhizomes with roots of Rumex confertus, 0.100 mg mL-1 and 0.005 mg mL-1 for the tincture of rhizomes with roots of Sanguisorba officinalis, 0.070 mg mL-1 and 0.002 mg mL-1 for the tincture of Rosa majalis roots, 0.080 mg mL-1 and 0.001 mg mL-1 for the tincture of Rosa canina roots, 0.01 mg mL-1 and 0.001 mg mL-1 for the tincture of Arctium lappa roots, 0.010 mg mL-1 and 0.002 mg mL-1 for the tincture of Arctium minus roots, 0.001 mg mL-1 and 0.002 mg mL-1 for the tincture of Arctium tomentosum roots, 0.070 mg mL-1 and 0.001 mg mL-1 for the tincture of Bidens tripartita herb, respectively.Conclusions. The quantitative content of total polyphenols and the amount of hydroxycinnamic acids in tinctures from rhizomes with roots of Rumex confertus, Sanguisorba officinalis, roots of Rosa majalis, Rosa canina, Arctium lappa, Arctium minus, Arctium tomentosum and the herb of Bidens tripartita have been determined. The data obtained will be used in further work on the study of tinctures of these types of the plant raw material.

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3

Jeelani, S., and M. A. Khuroo. "Triterpenoids from Arctium lappa." Natural Product Research 26, no. 7 (August 18, 2011): 654–58. http://dx.doi.org/10.1080/14786419.2010.541886.

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4

Leontyeva, Irina Aleksandrovna. "The study of burdock blossoms (Asteraceae: Arctium) entomofauna in the Yelabuga District of the Republic of Tatarstan." Samara Journal of Science 6, no. 4 (December 1, 2017): 53–57. http://dx.doi.org/10.17816/snv201764110.

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The paper deals with the study of burdock blossoms (Asteraceae : Arctium ) in the Yelabuga District of the Republic of Tatarstan where they are one of the most common species among the Compositae plants. They are mostly ruderal weeds, growing usually in waste places (abandoned orchards, wastelands, ravines, roadsides, river banks, dumps, walls of houses and fences, etc.). Some representatives of this genus are also found in the floodplain forests, sparse deciduous forests, clearings, forest edges. The paper presents some results of study of species composition and population structure of phytophagous insects, developing in inflorescences of four species of burdock ( Arctium tomentozum, Arctium minus, Arctium lappa, Arctium nemorosum ) on the territory of Yelabuga District of the Republic of Tatarstan. Seven experimental sites were examined, their total area is 1,0 hectares. The basic research was conducted during the spring-summer period in 2015-2017 at the time of active flowering plants. There were three kinds of flies-petrotrak (Diptera: Tephritidae), one kind of flies-Midge (in Russian spp.), one kind of beetle-weevil (Curculionidae) and one species of moth (Gelechiidae).

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5

Oproshanska, T., and O. Khvorost. "Potentiometric determination of organic acids in the medicinal plant raw material." News of Pharmacy, no. 1(101) (February 1, 2021): 11–17. http://dx.doi.org/10.24959/nphj.21.42.

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Aim. To analyze the results of the quantitative content of the amount of organic acids in rhizomes with roots of Rumex confertus, rhizomes with roots of Sanguisorba officinalis, roots of Rosa majalis and roots of Rosa canina, roots of Arctium minus and roots of Arctium tomentosum, herb of Bidens tripartite by the potentiometric method, which is available in the monograph “Hibiscus” in the SPhU 2.0. Materials and methods. The study subjects were batches of rhizomes with roots of Rumex confertus, rhizomes with roots of Sanguisorba officinalis, roots of Rosa majalis and roots of Rosa canina, roots of Arctium minus and roots of Arctium tomentosum, herb of Bidens tripartite. The quantitative content of the amount of organic acids was determined by the potentiometric method from the monograph “Hibiscus” SPhU 2.0 using a HI 2550 potentiometer of the “HANNA instruments” company (Germany). Results and discussion. The highest content of the amount of organic acids, among the study subjects was in roots of Arctium minus (from 1.02 ± 0.04 % to 1.05 ± 0.04 %). At the same time, in roots of Arctium tomentosum this amount was almost 3 times lower (from 0.36 ± 0.01 % to 0.37 ± 0.01 %). In the batches of roots of Rosa majalis the content of this group of compounds was almost 2 times higher than in roots of Rosa canina. In rhizomes with roots of Rumex confertus and rhizomes with roots of Sanguisorba officinalis the content of the amount of organic acids differed insignificantly. In herb of Bidens tripartite the content of this group of compounds was 0.78 ± 0.03 – 0.79 ± 0.03 %. In different batches of one type of the raw material the quantitative content of the amount of organic acids varied slightly. Conclusions. For the first time, the quantitative content of the amount of organic acids has been determined in the batches of rhizomes with roots of Rumex confertus, rhizomes with roots of Sanguisorba officinalis, roots of Rosa majalis and roots of Rosa canina, roots of Arctium minus and roots of Arctium tomentosum, herb of Bidens tripartite using the potentiometric method which is available in the monograph “Hibiscus” in the SPhU 2.0. It has been found that the highest content of the amount of organic acids is observed in roots of Arctium minus (not less than 1.02 %) and herb of Bidens tripartite (not less than 0.78 %). The results obtained will be used in further research when creating new herbal medicines with the anti-inflammatory and antimicrobial activity.

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6

Дьякова (Dyakova), Нина (Nina) Алексеевна (Аlekseevna). "DEVELOPMENT AND VALIDATION OF THE EXPRESS TECHNIQUE OF ALLOCATION AND QUANTITATIVE DEFINITION OF WATER-SOLUBLE POLYSACCHARIDES OF LEAVES OF ARCTIUM LAPPA L." chemistry of plant raw material, no. 4 (December 11, 2018): 81–87. http://dx.doi.org/10.14258/jcprm.2018042195.

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Research objective was development of an express technique of allocation and quantitative definition of water-soluble polysaccharides in leaves of a Arctium lappa L. For acceleration of process of extraction of biologically active agents of leaves of a Arctium lappa and also augmentations of an exit of water-soluble polysaccharides, it was decided to use an ultrasonic bathtub. Varying process indicators, it was succeeded to pick up extraction conditions under which process of extraction and quantitative definition of water-soluble polysaccharides of leaves of a Arctium lappa comes down to 1.5 h, namely: an izmelchennost of raw materials of 0.5–1.0 mm, temperature – 80 °С, frequency rate of extraction – 3, duration of extractions – 15 min, ultrasound frequency – 35 kHz, a ratio of raw materials and the ekstragent of 1 g for 15 ml. The developed technique of a validirovan on indicators of repeatability, correctness, fastness and linearity therefore it is proved that it is a pretsizionna in the conditions of repeatability, is correct, steady and has rather rigid linear dependence of mass of a deposit on mass of the analyzed raw materials at gravimetric definition of water-soluble polysaccharides in leaves of а Arctium lappa. The technique can be used for the express analysis of quality of leaves of а Arctium lappa and also at industrial receiving an inulin from this type of raw materials.

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7

Ghedira, K., and P. Goetz. "Arctium lappa L. (Asteraceae) : Bardane." Phytothérapie 11, no. 6 (December 2013): 376–80. http://dx.doi.org/10.1007/s10298-013-0827-1.

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8

Turdumambetov, K., G. A. Bakirov, and D. A. Rakhimov. "Glucofructans from Arctium tomentosum Roots." Chemistry of Natural Compounds 40, no. 3 (May 2004): 211–14. http://dx.doi.org/10.1023/b:conc.0000039125.29910.a1.

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9

Li, Jin, Chong Deng, Peng Zhao, Na Wang, and Lu Wang. "Kinetics on the Leaching of Polyphenol from Arctium lappal Root." Advanced Materials Research 586 (November 2012): 235–38. http://dx.doi.org/10.4028/www.scientific.net/amr.586.235.

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The kinetics parameters in the leaching of polyphenol from Arctium lappal root was studyed in this paper. According to second Fick’s law of diffusion, the kinetic equation for polyphenol leaching process was established with ball model. The results can provide the valuable theory basis for the technical design and further research of polyphenol from Arctium lappal root leaching process.

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10

Wu, Jian-Guo, Jin-Zhong Wu, Lian-Na Sun, Ting Han, Jian Du, Qi Ye, Hong Zhang, and Yu-Guang Zhang. "Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats." Phytomedicine 16, no. 11 (November 2009): 1033–41. http://dx.doi.org/10.1016/j.phymed.2009.04.005.

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11

Fante, Camila Argenta, Solange Dieterish, and Rubens Rodriguez. "Betametasona e extrato aquoso de Arctium lappa no tratamento da angiostrongilíase." Revista da Sociedade Brasileira de Medicina Tropical 41, no. 6 (December 2008): 654–57. http://dx.doi.org/10.1590/s0037-86822008000600018.

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Angiostrongylus costaricensis é um parasita que causa angiostrongilíase abdominal em humanos, seu tratamento inclui o uso de antiinflamatórios apesar da falta de estudos que justifiquem esta conduta. O objetivo deste artigo é avaliar o efeito da betametasona e da Arctium lappa na evolução de lesões intestinais induzidas pelo parasita. Utilizou-se camundongos Swiss, machos, adultos, distribuídos em 4 grupos: infectados tratados com betametasona; com Arctium lappa; não tratados e grupo controle. Os tratamentos iniciaram no 15º dia de infecção e permaneceram por 15 dias. Infiltrado eosinofílico e granuloma foram avaliados (1-leve; 2-moderado; 3-severo). A betametasona permitiu a evolução das lesões para formas mais graves, enquanto o extrato não interferiu na progressão da patologia. As substâncias empregadas não mostraram eficácia na proteção das lesões induzidas pelo Angiostrongylus costaricensis em camundongos. Estes achados desmotivam o uso de betametasona e Arctium lappa em humanos acometidos por angiostrongilíase abdominal.

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12

CONEA, Simona, Cristina MOGOSAN, Oliviu VOSTINARU, Claudia Crina TOMA, Ioana CUC HEPCAL, Irina CAZACU, Cristina POP, and Laurian VLASE. "Polyphenolic Profile, Anti-Inflammatory and Antinociceptive Activity of an Extract from Arctium lappa L. Roots." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 45, no. 1 (June 10, 2017): 59–64. http://dx.doi.org/10.15835/nbha45110549.

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The aim of the study was to assess the polyphenolic profile, anti-inflammatory and antinociceptive activity of Arctium lappa, a medicinal plant traditionally used in the treatment of gout, hepatitis and other inflammatory disorders. Polyphenolic profile of a hydro-glycero-ethanolic extract from Arctium lappa roots (ALE) was evaluated by HPLC-MS method. Anti-inflammatory effect of the Arctium lappa extract (ALE) was determined by carrageenan-induced rat paw oedema test, while antinociceptive effect was determined by acetic acid induced writhing test in mice and Randall Selitto test in rats. HPLC-MS analysis of the extract showed the presence of chlorogenic acid (158.9 μg/mL) and quercitrin (14.4 μg/mL). The administration of ALE reduced the oedema formation in the carrageenan-induced rat paw oedema test, especially at dose of 500 mg/kg, the results being statistically significant and dose-dependent. Also, ALE showed statistically significant and dose-dependent antinociceptive effects in the acetic acid induced writhing test in mice and Randall Selitto test in rats. The results of the pharmacological experiments suggest that the anti-inflammatory and antinociceptive effects of the Arctium lappa extract (ALE) may be related to the ability of polyphenols such as chlorogenic acid to inhibit the synthesis and release of some pro-inflammatory mediators. Our experimental data justify the traditional use of this plant in the management of some inflammatory disease.

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13

Duistermaat, Helena. "Typification of Arctium lappa L. (Asteraceae )." TAXON 52, no. 4 (November 2003): 851–52. http://dx.doi.org/10.2307/3647359.

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14

Takasugi, Mitsuo, Shinji Kawashima, Nobukatsu Katsui, and Akira Shirata. "Two polyacetylenic phytoalexins from Arctium lappa☆." Phytochemistry 26, no. 11 (1987): 2957–58. http://dx.doi.org/10.1016/s0031-9422(00)84570-7.

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15

WASHINO, Tsutomu, Hisakatsu IWABUCHI, Masahiro YOSHIKURA, and Shigeo OBATA. "Volatile constituents of Arctium lappa Linn." Journal of the agricultural chemical society of Japan 59, no. 4 (1985): 389–95. http://dx.doi.org/10.1271/nogeikagaku1924.59.389.

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16

WASHINO, Tsutomu, Masahiro YOSHIKURA, and Shigeo OBATA. "Polyacetylenic compounds of Arctium lappa L." Journal of the agricultural chemical society of Japan 60, no. 5 (1986): 377–83. http://dx.doi.org/10.1271/nogeikagaku1924.60.377.

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17

JAVZANDOLGOR, Chuluunbat, Shukherdorj BAASANMUNKH, Zagarjav TSEGMED, Batlai OYUNTSETSEG, Vanjil GUNDEGMAA, and Hyeok Jae CHOI. "Arctium tomentosum (Asteraceae): A new report of a native genus in the flora of Mongolia." Korean Journal of Plant Taxonomy 51, no. 4 (December 31, 2021): 391–94. http://dx.doi.org/10.11110/kjpt.2021.51.4.391.

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Arctium tomentosum Mill. (Asteraceae), from Ulaanbaatar in the Khentei phytogeographical region of Mongolia, is recognized here as a new genus and species of the flora of Mongolia. Arctium differs from other genera of Asteraceae by the hooked apex of the involucral bracts. While A. tomentosum is most similar to A. lappa, it is easily distinguished by the glandular hairs of the corolla limb and the widened inner involucral bracts. Taxonomic notes, a description of the morphology, detailed photos, habitat information, the phenology and a distribution map of A. tomentosum are provided.

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18

Rollo, C. David, J. D. MacFarlane, and B. S. Smith. "Electrophoretic and allometric variation in burdock (Arctium spp.): hybridization and its ecological implications." Canadian Journal of Botany 63, no. 7 (July 1, 1985): 1255–61. http://dx.doi.org/10.1139/b85-173.

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Allometric variation and insect seed predation among Arctium minus, A. lappa, and two possible hybrids were quantified. All four biotypes were also examined using isoelectric focusing, and differences among their proteins were found for alkaline phosphatases, leucine amino peptidases, esterases, and peroxidases. The allometric and electrophoretic results indicated that hybridization between A. minus and A. lappa is very common. The implications for the population dynamics of Arctium are discussed. The parental species are probably maintained by the combined effects of differential insect predation on the seeds, differential dispersal of seeds, and reduced seed viability in hybrids.

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19

Jing, Yang, Yu Qi, Liying Zhang, Guizhen Guo, and Xuanxuan Wang. "Arctiin Rescues Mitochondrial Functions Damage Induced by Ischemia and Reperfusion in PC12 Cells." Current Topics in Nutraceutical Research 20, no. 4 (March 8, 2022): 641–47. http://dx.doi.org/10.37290/ctnr2641-452x.20:641-647.

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Cerebral ischemia reperfusion injury refers to brain tissue damage during the restoration of blood supply. To develop effective therapeutic modalities, a better understanding of the molecular mechanisms of this process is needed. Arctium lappa L., a popular medicinal herb and health supplement, exhibits potent anti-inflammatory effect. Arctiin, a major active component of A. lappa L., seems to be responsible for its activity. However, the effects of arctiin in cerebral ischemia reperfusion, and the mechanism(s) involved is not clear. To this end, an in vitro oxygen-glucose deprivation/reperfusion model of PC12 cells was constructed. Results of our studies show that arctiin increased the survival rate, decreased apoptosis, and restored mitochondrial function of oxygen–glucose deprivation/reperfusion-induced PC12 cell. Furthermore, arctiin relieved mitochondrial functions damage via targeting extracellular signal-regulated kinase/mitogen-activated protein kinase pathway. These data highy suggest that arctiin could serve as a promising drug for the treatment of cerebral ischemia-reperfusion injury.

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20

Byung Hoon, Han, Kang Young Hwa, Yang Hyun Ok, and Man Ki Park. "A butyrolactone lignan dimer from Arctium lappa." Phytochemistry 37, no. 4 (November 1994): 1161–63. http://dx.doi.org/10.1016/s0031-9422(00)89550-3.

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21

UMEHARA, Kaoru, Ariko SUGAWA, Masanori KUROYANAGI, Akira UENO, and Takao TAKI. "Studies on Differentiation-Inducers from Arctium Fructus." CHEMICAL & PHARMACEUTICAL BULLETIN 41, no. 10 (1993): 1774–79. http://dx.doi.org/10.1248/cpb.41.1774.

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22

Tonea, Andrada, Mandra Badea, Liviu Oana, Sorina Sava, and Dan Vodnar. "Antibacterial and antifungal activity of endodontic intracanal medications." Medicine and Pharmacy Reports 90, no. 3 (July 25, 2017): 344–47. http://dx.doi.org/10.15386/cjmed-750.

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Background and aims. The sterilization of the entire root canal system represents the main goal of every endodontist, given the fact that the control of the microbial flora is the key point of every root canal treatment. The diversity of microorganisms found inside the root canal and also the resistance of some bacterial species to intracanal medications led to a continuous development of new endodontic products. The present study focuses on the comparison of the antibacterial and antifungal properties of different endodontic products, two commercially available, one experimental plant based extract, and two control substances.Methods. The disc diffusion assay was used to determine the antibacterial and antifungal properties of chlorhexidine, calcium hydroxide, a mix extract between Arctium lappa root powder and Aloe barbadensis Miller gel, Amoxicillin with clavulanic acid and Fluconazole (as control substances). Two of the most common microorganisms found in endodontic infections were chosen: Enterococcus faecalis (ATCC 29212) and Candida albicans ATCC(10231).Results. All tested substances showed inhibition zones around the discs, for Enterococcus faecalis and Candida albicans, including the experimental mix extract of Arctium lappa root powder with Aloe vera gel.Conclusion. The experimental mix extract of Arctium lappa root powder and Aloe vera gel is able to inhibit very resistant microorganisms, like Enterococcus faecalis and Candida albicans.

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23

Lee, Chung-Yuan, Min-Chieh Hsin, Pei-Ni Chen, Chiao-Wen Lin, Po-Hui Wang, Shun-Fa Yang, and Yi-Hsuan Hsiao. "Arctiin Inhibits Cervical Cancer Cell Migration and Invasion through Suppression of S100A4 Expression via PI3K/Akt Pathway." Pharmaceutics 14, no. 2 (February 5, 2022): 365. http://dx.doi.org/10.3390/pharmaceutics14020365.

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Arctiin, a lignan glycoside, is isolated from Arctium lappa L. The anticancer effects of arctiin have been demonstrated in several studies. However, no research has been conducted on the anti-migration effect of arctiin in cervical cancer cells. The present study examined the effects of arctiin on cervical cancer cells and investigated the possible molecular mechanism. We demonstrated that arctiin exhibited low cytotoxicity and significantly inhibited cell migration and invasion in human cervical cancer cells. The S100A4 protein expression and mRNA levels were significantly reduced in HeLa and SiHa cells with arctiin treatment. Furthermore, silencing S100A4 by using small interfering RNA reduced cell migration, while overexpression of S100A4 mitigated the migration inhibition imposed by arctiin in cervical cancer cells. Western blotting revealed that arctiin significantly reduced phosphoinositide 3-kinase (PI3K) and phosphorylation of Akt in cervical cancer cells. Moreover, selective Akt induction by an Akt activator, SC-79, reverted cervical cancer cell migration and S100A4 protein expression, which were reduced in response to arctiin. Taken together, these results suggest that arctiin inhibits cervical cancer cell migration and invasion through suppression of S100A4 and the PI3K/Akt pathway.

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Lin, Chun-Ching, Jer-Min Lin, Jeng-Jer Yang, Shu-Chuan Chuang, and Takashi Ujiie. "Anti-inflammatory and Radical Scavenge Effects of Arctium lappa." American Journal of Chinese Medicine 24, no. 02 (January 1996): 127–37. http://dx.doi.org/10.1142/s0192415x96000177.

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The effects of Arctium lappa L. (root) on anti-inflammatory and free radical scavenger activity were investigated. Subcutaneous administration of A. lappa crude extract significantly decreased carrageenan-induced rat paw edema. When simultaneously treated with CCl4, it produced pronounced activities against CCl4-induced acute liver damage. The free radical scavenging activity of its crude extract was also examined by means of an electron spin resonance (ESR) spectrometer. The IC50 of A. lappa extract on superoxide and hydroxyl radical scavenger activity was 2.06 mg/m 11.8 mg/m1, respectively. These findings suggest that Arctium lappa possess free radical scavenging activity. The inhibitory effects on carrageenan-induced paw edema and CCl4-induced hepatotoxicity could be due to the scavenging effect of A. lappa.

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Pasca, Claudia, Liviu Alexandru Marghitas, Daniel Severus Dezmirean, Otilia Bobiș, Victorita Bonta, Tania Mihăiescu, Flore Chirila, and Nicodim Fit. "MINERAL PROFILE EVOLUTION OF SOME MEDICINAL PLANTS WITH ANTIBACTERIAL EFFECTS." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Animal Science and Biotechnologies 73, no. 2 (November 28, 2016): 223. http://dx.doi.org/10.15835/buasvmcn-asb:12295.

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Individual minerals and antibacterial activity were investigated in 5 medicinal plants (pot marigold - Calendula officinalis, burdock - Arctium lappa, celandine - Chelidonium majus, basil- Ocimum basilicum, thyme - Thymus vulgaris) using Atomic Absorption Spectroscopy (AAS) technique and antibiogram method. The antibacterial susceptibility has been evaluated over 12 strains isolated from milk microflora, belonging to Staphylococcus, Vibrio, Serratia and Bacillus genera. The obtained results show the best antibacterial effect with Arctium lappa ethanol extracts, having inhibition areas of 6.3 to 17.5 mm, with an average of 9.0 mm and the highest determined mineral being Calcium. The results obtained open the prospect of using these medicinal plants as an alternative to be used for the control and cure of some mineral deficiencies or for preventing various diseases of the animals.

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Kolomiets, Natalia Eduardovna, Roman Sergeevich Boev, Lyudmila Vladimirovna Zhalnina, Valeria Andreevna Tikhomirova, Denis Radikovich Kashapov, Ruslan Anatolievich Bondarchuk, Tatyana Petrovna Novozheeva, Natal'ya Yur'yevna Abramets, Sergei Mikhailovich Safronov, and Abduljalil Qaid Hasan Ali. "CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF METABOLITES OF SPECIES OF THE GENUS ARCTIUM L." chemistry of plant raw material, no. 2 (June 10, 2021): 29–57. http://dx.doi.org/10.14258/jcprm.2021028315.

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The review summarizes information from the literature on the distribution, study of the composition and biological activity of metabolites, total extracts of plants of the genus Arctium L. of the world flora. In Russia, the roots of three species are allowed to be harvested and used: A. lappa, A. tomentosum, A. minus. To date, the most studied composition of metabolites and pharmacological properties of great burdock. The chemical composition of A. atlanticum, A. debrayi, A. leiobardanum, A. neumani, A. platylepis, A. pseudarctium, A. sardaimionense, A. scanicum, A. nemorosum and A. palladini has not been studied. About 360 substances related to polysaccharides, sesquiterpenes, triterpenes, fatty acids, phenolcarbonic acids, tannins, vitamins, lignans, sterols, polyacetylenes, amino acids, alkaloids, flavonoids, macro-and microelements and other were isolated and identified from the studied species. There are only a few publications about pharmacological activity of Arctium nemorosum, A. palladini, A. tomentosum and A. minus, and there is no information for other types. Total extracts and individual compounds of the studied burdock species in the experiment have a wide range of pharmacological activity. The information provided in the review shows that plants of the genus Arctium L., are promising for creating effective medicines. In addition, the fragmentation and lack of information on the composition of metabolites, pharmacological activity of most species of the genus burdock opens up great opportunities for researchers.

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A. Taher, Mohammed, Dhuha A. Abdul- Hussain, Huda F. Hasan, Zena M. Fahmi, Oday K. Luaibi, and Mezaal G. Ali. "Hypolipidemic Effect of Caffeic Acid Isolated From Arctium Lappa Cultivated In Iraq, in Hyperlipidemic Rat Model." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 24, no. 1 (February 23, 2018): 18–24. http://dx.doi.org/10.31351/vol24iss1pp18-24.

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The goal of the extant revision was to explore the influence of caffeic acid (CA) extracted from Arctium lappa L. on lipid profile and histology of aorta in rats . Analytical study demonstrated a high percentage of both chlorogenic and caffeic acid in the 80 % methanol extract of the aerial parts (leaves and stems) of Arctium lappa L. from the family Asteraceace. Hypolipidemic activity of caffeic acid was studied against cholesterol induced hypercholesterolemia in Wistar albino rats for thirty days. Rats were separated into normal group (A), hypercholesterolemic positive controller group (B). While, the rest three groups (C, D and E) attended as hypercholesterolemic trial groups. Caffeic acid was given verbally at doses of 20 mg / kg body mass in Collection (C), 40 mg/kg in Collection(D) then 20 mg/ kg in collection (E) after two weeks of administration of cholesterol induced hypercholesterolemia. There was an obvious histological improvement of changes induced by hypercholesteremia in aorta. Furthermore, using (CA) at 20mg after 2 weeks of feeding on cholesterol rich diet led to a important decline (P<0.05) in serum whole cholesterol levels in compassion with the control and cholesterol rich diet group. Moreover, There was a great improvement in the histology results convinced by the high cholesterol gorgeous diet, which can partly be attributed to an antioxidant activity of (CA). Keywards: Arctium lappa, Caffeic acid , Hypolipidimic, Hypercholesterolemia.

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WASHINO, Tsutomu, Masahiro YOSHIKURA, and Shigeo OBATA. "New sulfur-containing acetylenic compounds from Arctium lappa." Agricultural and Biological Chemistry 50, no. 2 (1986): 263–69. http://dx.doi.org/10.1271/bbb1961.50.263.

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Rodriguez, P., J. Blanco, S. Juste, M. Garcés, R. Pérez, L. Alonso, and M. Marcos. "Allergic contact dermatitis due to burdock (Arctium lappa)." Contact Dermatitis 33, no. 2 (August 1995): 134–35. http://dx.doi.org/10.1111/j.1600-0536.1995.tb00524.x.

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HEILMEIER, H., and D. M. WHALE. "Partitioning of 14C Labelled Assimilates in Arctium tomentosum." Annals of Botany 57, no. 5 (May 1986): 655–66. http://dx.doi.org/10.1093/oxfordjournals.aob.a087148.

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Heilmeier, H., and D. M. Whale. "Carbon dioxide assimilation in the flowerhead of Arctium." Oecologia 73, no. 1 (August 1987): 109–15. http://dx.doi.org/10.1007/bf00376985.

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Pereira, Juliana Vianna, Débora Cristina Baldoqui Bergamo, José Odair Pereira, Suzelei de Castro França, Rosemeire Cristina Linhares Rodrigues Pietro, and Yara T. Corrêa Silva-Sousa. "Antimicrobial activity of Arctium lappa constituents against microorganisms commonly found in endodontic infections." Brazilian Dental Journal 16, no. 3 (December 2005): 192–96. http://dx.doi.org/10.1590/s0103-64402005000300004.

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This study evaluated in vitro the antimicrobial activity of rough extracts from leaves of Arctium lappa and their phases. The following microorganisms, commonly found in the oral cavity, specifically in endodontic infections, were used: Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis and Candida albicans. The agar-diffusion method allowed detection of the hexanic phase as an inhibitor of microbial growth. Bioautographic assays identified antimicrobial substances in the extract. The results showed the existence, in the rough hexanic phase and in its fractions, of constituents that have retention factors (Rf) in three distinct zones, thereby suggesting the presence of active constituents with chemical structures of different polarities that exhibited specificity against the target microorganisms. It may be concluded that the Arctium lappa constituents exhibited a great microbial inhibition potential against the tested endodontic pathogens.

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Tezuka, Yasuhiro, Keiichi Yamamoto, Suresh Awale, Feng Li, Satoshi Yomoda, and Shigetoshi Kadota. "Anti-austeric Activity of Phenolic Constituents of Seeds of Arctium lappa." Natural Product Communications 8, no. 4 (April 2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800414.

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From seeds of Arctium lappa L. (Asteraceae) we obtained arctigenin (1), arctiin (2), chlorogenic acid (3), 4,5-dicaffeoylquinic acid (4), 3,5-dicaffeoylquinic acid (5), 3,4-dicaffeoylquinic acid (6), matairesinol (11), isolappaol A (12), lappaol F (14), and lappaol B (15), together with 1:1 mixtures of isolappaol C (7) and lappaol C (8), arctignan E (9) and arctignan D (10), and 12 and lappaol A (13), while 3,3′,4′-tri- O-demethylarctigenin (16), 3,3′-di- O-demethyl-4′-dehydroxyarctigenin (17), and 3- O-demethylarctigenin (18) were obtained by anaerobic microbiological metabolism of 1. Then, we evaluated the in vitro preferential cytotoxic activity of these pure compounds and 1:1 mixtures, together with enterodiol (19) and enterolactone (20), against human pancreatic cancer PANC-1 cells in nutrient-deprived medium (NDM). Among them, 1 and 18 showed potent activity, with PC50 values of 1.75 and 4.38 μ M, respectively, while 11, 15, and 17 showed mild activity with PC50 values of 31.1, 30.9, and 38.7 μ/M, respectively. By comparing their structures and PC50 values, the following structural moieties could be concluded to be important for the preferential cytotoxicity of 1: 1) the 3-hydroxy-4-methoxyphenyl group at the 2-position on the γ-butyrolactone ring, 2) the less polar substituent at the 3-position on the γ-butyrolactone ring, and 3) the γ-butyrolactone ring.

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Lee, Mee-Sook. "Antioxidative and Antimutagenic Effects of Arctium lappa Ethanol Extract." Korean Journal of Food And Nutrition 24, no. 4 (December 31, 2011): 713–19. http://dx.doi.org/10.9799/ksfan.2011.24.4.713.

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Nealen, Herman J., and Paul M. Nealen. "Ruby-throated Hummingbird Death by Common Burdock (Arctium minus)." Wilson Bulletin 112, no. 3 (September 2000): 421–22. http://dx.doi.org/10.1676/0043-5643(2000)112[0421:rthdbc]2.0.co;2.

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Nascimento, Bruno A. C., Luiz G. Gardinassi, Inaê M. G. Silveira, Marília G. Gallucci, Mariana A. Tomé, Júlia Fernanda D. Oliveira, Mirella R. A. Moreira, et al. "Arctium lappa Extract Suppresses Inflammation and Inhibits Melanoma Progression." Medicines 6, no. 3 (July 29, 2019): 81. http://dx.doi.org/10.3390/medicines6030081.

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Background: Arctium lappa has been used as popular medicinal herb and health supplement in Chinese societies. Bioactive components from A. lappa have attracted the attention of researchers due to their promising therapeutic effects. In this study, we investigated the effects of A. lappa hydroalcoholic extract (Alhe) during different models of inflammation, in vivo. Methods: The anti-inflammatory activity was evaluated through the air pouch model. For this, mice received an inflammatory stimulus with lipopolysaccharide (LPS) and were later injected with Alhe. To assess anti-tumoral activity, the animals were inoculated with B16F10 cells and injected with Alhe every 5 days, along the course of 30 days. Controls were submitted to the same conditions and injected with the vehicle. Peritoneal or air pouch fluids were collected to evaluate leukocyte counting or cellular activation via quantification of cytokines and nitric oxide. Results: Alhe injection reduced the neutrophil influx and production of inflammatory mediators in inflammatory foci after LPS or tumor challenges. Furthermore, Alhe injection reduced tumor growth and enhanced mice survival. Conclusions: Collectively, these data suggest that Alhe regulates immune cell migration and activation, which correlates with favorable outcome in mouse models of acute inflammation and melanoma progression.

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Stobbs, L. W. "Occurrence and Characterization of a Potexvirus Infecting Arctium minus." Plant Disease 72, no. 4 (1988): 314. http://dx.doi.org/10.1094/pd-72-0314.

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He, Jun, Xiao-Ying Huang, Ya-Nan Yang, Zi-Ming Feng, Jian-Shuang Jiang, and Pei-Cheng Zhang. "Two new compounds from the fruits of Arctium lappa." Journal of Asian Natural Products Research 18, no. 5 (March 16, 2016): 423–28. http://dx.doi.org/10.1080/10286020.2016.1145671.

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Yong, Min, Gu Kun, and Min-Hua Qiu. "A new lignan from the seeds of Arctium lappa." Journal of Asian Natural Products Research 9, no. 6 (September 1, 2007): 541–44. http://dx.doi.org/10.1080/10286020600882577.

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Kato, Yoji, and Toshiyuki Watanabe. "Isolation and Characterization of a Xyloglucan fromGobo(Arctium lappaL.)." Bioscience, Biotechnology, and Biochemistry 57, no. 9 (January 1993): 1591–92. http://dx.doi.org/10.1271/bbb.57.1591.

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Zhang, Da-Chuan, Yan-Ping Xing, Liang Xu, Rong Zhao, Yan-Yun Yang, Ting-Ting Zhang, Sheng-Nan Li, and Ting-Guo Kang. "The complete mitochondrial genome of Arctium lappa (Campanulales, Asteraceae)." Mitochondrial DNA Part B 5, no. 2 (April 2, 2020): 1722–23. http://dx.doi.org/10.1080/23802359.2020.1749153.

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Lee, Seul, Hye-Kyung Moon, Il-Doo Kim, and Dong-Hyun Shin. "Physicochemical Characteristics of Different Parts of Burdock (Arctium sp.)." Current Research on Agriculture and Life Sciences 32, no. 2 (June 30, 2014): 75–78. http://dx.doi.org/10.14518/crals.2014.32.2.014.

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Liu, Changda, Kamal D. Srivastava, Nan Yang, Madisyn A. Primas, Renna Bushko, Kyle Chin, Matthew Batnick, and Xiu-Min Li. "Arctigenin Isolated from Arctium Lappa L. Inhibits IgE Production." Journal of Allergy and Clinical Immunology 137, no. 2 (February 2016): AB236. http://dx.doi.org/10.1016/j.jaci.2015.12.954.

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Kravtsova, S. S., and V. V. Khasanov. "Lignans and fatty-acid composition of Arctium lappa seeds." Chemistry of Natural Compounds 47, no. 5 (November 2011): 800–801. http://dx.doi.org/10.1007/s10600-011-0064-5.

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Azizov, U. M., U. A. Khadzhieva, D. A. Rakhimov, L. G. Mezhlumyan, and S. A. Salikhov. "Chemical composition of dry extract of Arctium lappa roots." Chemistry of Natural Compounds 47, no. 6 (January 2012): 1038–39. http://dx.doi.org/10.1007/s10600-012-0142-3.

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46

Ikeda, Masafumi, Akihiro Sato, Nobuo Mochizuki, Kayo Toyosaki, Chika Miyoshi, Rumi Fujioka, Shuichi Mitsunaga, et al. "A phase I trial of GBS-01 for advanced pancreatic cancer refractory to gemcitabine." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 2559. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.2559.

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2559 Background: Arctigenin, which is abundant in the seeds of Arctium lappa Linné, was found by a novel strategy to attenuate cancer cells’ tolerance to glucose deprivation (antiausterity) and showed antitumor activity in mouse xenograft models. GBS-01 is an orally administered drug and contains rich arctigenin extracted from Arctium lappa Linné, which is one of the traditional herbal medicine. This study investigated the maximum-tolerated dose of GBS-01 based on the frequency of dose-limiting toxicities (DLT) in patients with refractory advanced pancreatic cancer, which is considered as one of the hypoxic cancer. Methods: Histologically or cytologically proven advanced pancreatic adenocarcinoma patients refractory to gemcitabine were enrolled. GBS-01 was administered orally at escalating doses from 3g to 12g qd. DLT was defined as grade 4 hematological toxicities and grade 3 or 4 non-hematological toxicities during first 28 days of the treatment. Response evaluation based on RECIST criteria and progression-free survival were set as secondary endpoint for efficacy evaluation. Results: Fifteen patients (GBS-01 3g: 3 patients, 7.5g: 3 patients, 12g: 9 patients) were enrolled in this trial. All patients were refractory to S-1 as well as gemcitabine. All patients at the three dose levels did not demonstrate any sign of DLT. The main adverse events of this agent were increased γGTP, hyperglycemia, and increased total bilirubin, but all toxicities were extremely mild. Of all 15 enrolled patients, 1 patient showed a partial response and 4 patients had a stable disease. The median progression-free and overall survival time for all patients were 1.05 months and 5.68 months, respectively. Conclusions: The recommended dose of GBS-01 was 12 g qd (4 g as a extract of Arctium lappa Linné), and favorable clinical responses were obtained. A multicenter phase II trial is being planned to evaluate the efficacy and safety of this agent. Clinical trial information: 000005787.

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Teixeira, Renan S., Paulo H. D. Carvalho, Jair A. K. Aguiar, Valquíria P. Medeiros, Ademar A. Da Silva Filho, and Jorge W. L. Nascimento. "Improved Method for Obtaining of Arctigenin from Arctium Lappa L. and its Antiproliferative Effect on Human Hepatocarcinoma HepG2 Cells." Current Bioactive Compounds 16, no. 3 (June 10, 2020): 358–62. http://dx.doi.org/10.2174/1573407214666181115124223.

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Background: Arctigenin is a lignan found in Arctium lappa L. (Asteraceae) that displays anti-inflammatory activities. Previous studies showed that the crude extract of A. Lappa has antitumor activity in human liver carcinoma, lung and stomach cancer cells. The aim of this study was to obtain arctigenin from A. lappa L., as well as to evaluate its antiproliferative effects in cells of liver carcinoma (HepG2) and fibroblasts (NIH/3T3). Methods: Arctigenin was obtained from the hydrolysis of arctiin, which was isolated from the crude extract of A. lappa. The effects of arctigenin and arctiin on HepG2 cell viability and cell adhesion were analyzed by MTT method. Adhesion assay was also carried out to evaluate the antitumor activity. Results: Our results showed that the analytical process to obtain arctigenin was fast and easy. In vitro experiments showed that arctigenin (107-269 μM) decreased HepG2 cells viability and did not cause cytotoxicity on NIH/3T3 cells. Arctigenin (27-269 μM) demonstrated anti-adhesion in HepG2 cells in a concentration-dependent manner, when compared with control. Conclusion: These results suggest a promising pharmacological activity for arctigenin as an antiproliferative compound.

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Silverio, Juliana Milene, Cleberton Correia Santos, Rodrigo da Silva Bernardes, Giselly Marques Espíndola, Hércules Lazari Meurer, and Maria do Carmo Vieira. "GERMINAÇÃO DE SEMENTES E VIGOR DE PLÂNTULAS DE Arctium lappa L. SUBMETIDAS À TOXICIDADE DE ALUMÍNIO." Revista Brasileira de Engenharia de Biossistemas 15, no. 1 (July 26, 2021): 154–67. http://dx.doi.org/10.18011/bioeng2021v15n1p154-167.

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O alumínio (Al) presente nos solos ácidos reduz o potencial fisiológico de sementes e limita o crescimento plântulas de diversas espécies de interesse agronômico. Entretanto, informações quanto à toxicidade do Al em Arctium lappa L. (bardana, Asteraceae) são escassos. Objetivou-se nesse estudo avaliar o efeito do estresse por alumínio na germinação e no vigor de plântulas de A. lappa. Foram testadas cinco concentrações de sulfato de alumínio hidratado Al2(SO4)3·16H2O: 0 (controle), 5, 10, 15 e 20 mmol L-1. O teste de germinação foi feito em caixas do tipo Gerbox (sobre papel – SP) e em rolo papel – RP, utilizando papel germitest® umedecidos 2,5 vezes seu peso seco. As sementes foram mantidas em câmaras de B.O.D, sob 20-30ºC e luz branca constante. O potencial fisiológico das sementes e vigor de plântulas foi avaliado por meio dos testes de primeira contagem de germinação (4 dias), germinação (7 dias) e comprimento de plântulas. Observamos redução da germinação conforme aumento das concentração de Al em substrato SP. Os menores comprimentos da parte aérea das plântulas ocorreram com 20 mmol L-1 de Al e no substrato SP. Ocorreu inibição radicular das plântulas conforme aumento das concentração de Al nos dois substratos, especialmente no SP. O estresse por alumínio e substrato SP afetou negativamente a germinação de sementes e vigor das plântulas de A. lappa.

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O., Sokol, Dzhurenko N., and Gournenko I. "The ultrastructural features of pollens grains in species of the genus Arctium L. (Asteraceae Bercht. & J.Presl)." Visnyk of Lviv University. Biological series, no. 80 (June 25, 2019): 67–72. http://dx.doi.org/10.30970/vlubs.2019.80.08.

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Lee, Dong-Sub, and Jin-Sik Park. "Removal Efficiency of odor substance Using Arctium Lappa Root extract." Journal of Environmental Science International 23, no. 11 (November 28, 2014): 1953–61. http://dx.doi.org/10.5322/jesi.2014.23.11.1953.

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