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Dissertations / Theses on the topic 'Area under the error curve'

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Published: 4 June 2025

Last updated: 1 August 2025

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1

Zheng, Shimin. "The ROC Curve and the Area under the Curve (AUC)." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/139.

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池田, 充., Takeo Ishigaki, Mitsuru Ikeda, 一信山内, and Kazunobu Yamauchi. "Relationship between Brier score and area under the binormal ROC curve." Elsevier, 2002. http://hdl.handle.net/2237/5310.

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Sun, Fangfang. "Semi-parametric inference for the partial area under the ROC curve." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-11192008-113213/.

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Thesis (M.S.)--Georgia State University, 2008.<br>Title from file title page. Gengsheng Qin, committee chair; Yu-Sheng Hsu, Yixin Fang, Yuanhui Xiao, committee members. Description based on contents viewed July 22, 2009. Includes bibliographical references (p. 29-30).

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Galadima, Hadiza I. "Controlling for Confounding when Association is Quantified by Area Under the ROC Curve." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3905.

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In the medical literature, there has been an increased interest in evaluating association between exposure and outcomes using nonrandomized observational studies. However, because assignments to exposure are not done randomly in observational studies, comparisons of outcomes between exposed and non-exposed subjects must account for the effect of confounders. Propensity score methods have been widely used to control for confounding, when estimating exposure effect. Previous studies have shown that conditioning on the propensity score results in biased estimation of odds ratio and hazard ratio.

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Stukel, Diana M. (Diane Maria) Carleton University Dissertation Mathematics. "Small area estimation under one and two-fold nested error regression models." Ottawa, 1991.

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6

Wang, Wen-Chyi. "Regularized variable selection in proportional hazards model using area under receiver operating characteristic curve criterion." College Park, Md.: University of Maryland, 2009. http://hdl.handle.net/1903/9972.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2009.<br>Thesis research directed by: Dept. of Mathematics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Nguyen, Dong-Hai. "Facilitating students application of the integral and the area under the curve concepts in physics problems." Diss., Kansas State University, 2011. http://hdl.handle.net/2097/8631.

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Doctor of Philosophy<br>Department of Physics<br>Nobel S. Rebello<br>This research project investigates the difficulties students encounter when solving physics problems involving the integral and the area under the curve concepts and the strategies to facilitate students learning to solve those types of problems. The research contexts of this project are calculus-based physics courses covering mechanics and electromagnetism. In phase I of the project, individual teaching/learning interviews were conducted with 20 students in mechanics and 15 students from the same cohort in electromagnetism.

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Shen, C. "Some Significant Results in the Classification Analysis of the Spectroscopic Evaluation of Cervical Cancer." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/math_theses/9.

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Cervical Cancer is the second most common type of cancer in women worldwide (500,000 cases/year) and one of the leading causes of cancer-related mortality in women in developing countries (230,000 cases/year). The Spectrx LightTouch™ device uses light to detect chemical and structural changes in cervical tissue. Light responds differently when exposed to normal cells and cancerous cells. The purpose of this research is to find the best model that can be used to diagnose the early cervical cancerous conditions. To achieve this goal, we first tried to reduce the number of variables. We use sta

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Zhu, Yao-Wei. "LIMITED SAMPLING STRATEGIES FOR FACILE DETERMINATION OF THE AREA UNDER THE CURVE OF ANTI-CANCER AGENTS, PACLITAXEL AND SU5416." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin984580545.

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Dunning, Allison. "Comparing Bootstrap and Jackknife Variance Estimation Methods for Area Under the ROC Curve Using One-Stage Cluster Survey Data." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1849.

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The purpose of this research is to examine the bootstrap and jackknife as methods for estimating the variance of the AUC from a study using a complex sampling design and to determine which characteristics of the sampling design effects this estimation. Data from a one-stage cluster sampling design of 10 clusters was examined. Factors included three true AUCs (.60, .75, and .90), three prevalence levels (50/50, 70/30, 90/10) (non-disease/disease), and finally three number of clusters sampled (2, 5, or 7). A simulated sample was constructed for each of the 27 combinations of AUC, prevalence

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Liu, Hua. "ASYMPTOTIC PROPERTIES OF PARTIAL AREAS UNDER THE RECEIVER OPERATING CHARACTERISTIC CURVE WITH APPLICATIONS IN MICROARRAY EXPERIMENTS." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/463.

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Receiver operating characteristic (ROC) curves are widely used in medical decision making. It was recognized in the last decade that only a specific region of the ROC curve is of clinical interest, which can be summarized by the partial area under the ROC curve (partial AUC). Early statistical methods for evaluating partial AUC assume that the data are from a specified underlying distribution. Nonparametric estimators of the partial AUC emerged recently, but there are theoretical issues to be addressed. In this dissertation, we propose two new nonparametric statistics, partially integrated ROC

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Barbagallo, Raffaele. "Innovative characterization and elastoplastic modelling of metals under static and dynamic conditions." Doctoral thesis, Università di Catania, 2018. http://hdl.handle.net/10761/4170.

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Material characterization and modelling are fundamental in both Industry and Research worlds in order to have reliable FEM simulations. In this research, such procedures are investigated regarding quasistatic and dynamic tests on metals. According to several experiments reported in the literature, the static elastoplastic behaviour of such materials depends not only on the first stress invariant (triaxiality) for the ductile damage and on the second stress invariant (equivalent von Mises stress) for the yield, but also on the third stress invariant (normalized Lode angle X) which may affect at

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Mistry, Pritesh. "A Knowledge Based Approach of Toxicity Prediction for Drug Formulation. Modelling Drug Vehicle Relationships Using Soft Computing Techniques." Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14440.

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This multidisciplinary thesis is concerned with the prediction of drug formulations for the reduction of drug toxicity. Both scientific and computational approaches are utilised to make original contributions to the field of predictive toxicology. The first part of this thesis provides a detailed scientific discussion on all aspects of drug formulation and toxicity. Discussions are focused around the principal mechanisms of drug toxicity and how drug toxicity is studied and reported in the literature. Furthermore, a review of the current technologies available for formulating drugs for toxicit

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Huang, Xin. "Some Topics in Roc Curves Analysis." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/math_diss/3.

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The receiver operating characteristic (ROC) curves is a popular tool for evaluating continuous diagnostic tests. The traditional definition of ROC curves incorporates implicitly the idea of "hard" thresholding, which also results in the empirical curves being step functions. The first topic is to introduce a novel definition of soft ROC curves, which incorporates the idea of "soft" thresholding. The softness of a soft ROC curve is controlled by a regularization parameter that can be selected suitably by a cross-validation procedure. A byproduct of the soft ROC curves is that the corresponding

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Henriques, Luciana dos Santos. "Avaliação da farmacocinética da ciclosporina em crianças com síndrome nefrótica idiopática." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-04112010-153429/.

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Foi realizado um estudo prospectivo em dez crianças (média de idade de apresentação da doença, 3.0 ± 1.6 anos) usando ciclosporina (CSA) uma microemulsão utilizada no tratamento da síndrome nefrótica idiopática (SNI) - com função renal normal avaliada pelo clearance de creatinina estimado pela estatura, que apresentavam o C0 (nível do vale) entre 50 e 150 ng/ml e que encontraram remissão completa da doença com a CSA. O objetivo foi comparar os parâmetros farmacocinéticos da CSA entre crianças com SNI em remissão ou descompensadas da doença. O perfil farmacocinético da CSA foi avaliado através

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Kutálek, David. "Statistická analýza ROC křivek." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2010. http://www.nusl.cz/ntk/nusl-229036.

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The ROC (Receiver Operating Characteristic) curve is a projection of two different cumulative distribution functions F0 and F1. On axis are values 1-F0(c) and 1-F1(c). The c-parameter is a real number. This curve is useful to check quality of discriminant rule which classify an object to one of two classes. The criterion is a size of an area under the curve. To solve real problems we use point and interval estimation of ROC curves and statistical hypothesis tests about ROC curves.

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Tang, Tian. "Infrared Spectroscopy in Combination with Advanced Statistical Methods for Distinguishing Viral Infected Biological Cells." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/math_theses/59.

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Fourier Transform Infrared (FTIR) microscopy is a sensitive method for detecting difference in the morphology of biological cells. In this study FTIR spectra were obtained for uninfected cells, and cells infected with two different viruses. The spectra obtained are difficult to discriminate visually. Here we apply advanced statistical methods to the analysis of the spectra, to test if such spectra are useful for diagnosing viral infections in cells. Logistic Regression (LR) and Partial Least Squares Regression (PLSR) were used to build models which allow us to diagnose if spectral differences

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Verdi, Marcio. "Prediçao de distribuíção de espécies arbustivo-arbóreas no sul do Brasil." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/115515.

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Em vista das mudanças ambientais em nível global, disponibilizar informações ecológicas e buscar uma melhor compreensão dos fatores e processos que moldam a distribuição de espécies, é uma iniciativa importante para o planejamento de ações de conservação. Neste contexto, a importância e carência de informações sobre a distribuição geográficas das espécies nos motivaram a predizer a distribuição potencial de arbustos e árvores das famílias Lauraceae e Myrtaceae na Floresta Atlântica, no sul do Brasil. Modelos lineares generalizados (GLM) foram usados para ajustar modelos preditivos com os regis

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Nalavolu, Praveen Reddy. "PERFORMANCE ANALYSIS OF SRCP IMAGE BASED SOUND SOURCE DETECTION ALGORITHMS." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_theses/50.

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Steered Response Power based algorithms are widely used for finding sound source location using microphone array systems. SRCP-PHAT is one such algorithm that has a robust performance under noisy and reverberant conditions. The algorithm creates a likelihood function over the field of view. This thesis employs image processing methods on SRCP-PHAT images, to exploit the difference in power levels and pixel patterns to discriminate between sound source and background pixels. Hough Transform based ellipse detection is used to identify the sound source locations by finding the centers of elliptic

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Žbánková, Alena. "Analýza intrakardiálního elektrogramu v závislosti na transmuralitě ablační léze při katétrové radiofrekvenční ablaci srdečních arytmií." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2013. http://www.nusl.cz/ntk/nusl-220064.

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Catheter ablation is a unique method for cardiac arrhythmias treatment based on creating spot lesions of radiofrequency energy using intracardiac ablation catheter. Transmurality of these lesions should be achieved for long-term therapeutic treatment effect. The degree of myocardial damage depth is reflected in the parameters of sensed intracardiac ECG. From research studies is evident that the change in morphology and deflection of ablation signal play a key role in the assessment of transmurality. This thesis consists of theoretical introduction to electrophysiology, proposal and realization

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Glisson, Wesley J., Courtney J. Conway, Christopher P. Nadeau, and Kathi L. Borgmann. "Habitat models to predict wetland bird occupancy influenced by scale, anthropogenic disturbance, and imperfect detection." WILEY, 2017. http://hdl.handle.net/10150/625200.

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Understanding species-habitat relationships for endangered species is critical for their conservation. However, many studies have limited value for conservation because they fail to account for habitat associations at multiple spatial scales, anthropogenic variables, and imperfect detection. We addressed these three limitations by developing models for an endangered wetland bird, Yuma Ridgway's rail (Rallus obsoletus yumanensis), that examined how the spatial scale of environmental variables, inclusion of anthropogenic disturbance variables, and accounting for imperfect detection in validation

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Luo, Shan. "Advanced Statistical Methodologies in Determining the Observation Time to Discriminate Viruses Using FTIR." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/math_theses/86.

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Fourier transform infrared (FTIR) spectroscopy, one method of electromagnetic radiation for detecting specific cellular molecular structure, can be used to discriminate different types of cells. The objective is to find the minimum time (choice among 2 hour, 4 hour and 6 hour) to record FTIR readings such that different viruses can be discriminated. A new method is adopted for the datasets. Briefly, inner differences are created as the control group, and Wilcoxon Signed Rank Test is used as the first selecting variable procedure in order to prepare the next stage of discrimination. In the seco

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Araújo, Lilian Monteiro Pereira. ""Co-interferências da farmacocinética dos inibidores de calcineurina em associação com micofenolato mofetil em pacientes transplantados renais"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-13092006-155555/.

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Para avaliar a exposição ao ácido micofenólico (MPA) na fase inicial pós-transplante renal, receptores foram destinados para receber tacrolimo (n=33) ou ciclosporina (n=19, controle) com MMF. Foram feitas coletas de farmacocinética (AUC) do inibidor de calcineurina e MPA nos dias 7, 14, 30, 60 e 180 pós-transplante. Dos dias 14-180, a MPA-AUC foi mais elevada no grupo tacrolimo devido a um maior segundo pico de MPA. Com doses fixas de MMF, uma grande porcentagem de curvas ficou abaixo da faixa terapêutica. No dia 7, a equação que emprega a concentração pré-dose (C0) e na segunda hora (C2) foi

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AGUIAR, Renata Alves de. "Manejo do mofo branco (Sclerotinia sclerotiorum L.) em tomateiro industrial." Universidade Federal de Goiás, 2011. http://repositorio.bc.ufg.br/tede/handle/tde/444.

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Made available in DSpace on 2014-07-29T14:52:07Z (GMT). No. of bitstreams: 1 Renata Alves.pdf: 1312984 bytes, checksum: 4ed5f4555216a682f038513b0c3af4a6 (MD5) Previous issue date: 2011-08-30<br>Brazil ranks ninth in the world production of tomato (Solanum esculentum L.), while much of this production is destined for processing industries. The added value obtained with the fruit processing endorses this species as the vegetable with the greatest economic importance in the Cerrado region of Brazil, where the State of Goiás stands out as the largest producer. Despite the favorable soil an

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Lin, Shu-Chuan. "Robust estimation for spatial models and the skill test for disease diagnosis." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26681.

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Thesis (Ph.D)--Industrial and Systems Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Lu, Jye-Chyi; Committee Co-Chair: Kvam, Paul; Committee Member: Mei, Yajun; Committee Member: Serban, Nicoleta; Committee Member: Vidakovic, Brani. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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Santos, Verônica Jorge. "Modelagem farmacocinética-farmacodinâmica da morfina administrada através de bomba controlada pelo paciente no pós-operatório de revascularização do miocárdio." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-05052008-142710/.

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Introdução: A administração de morfina através de bomba de infusão controlada pelo paciente (ACP) no tratamento da dor pós-cirurgica e traumática tem-se mostrado promissora e faz parte da rotina terapêutica de muitos hospitais. No entanto, doses altas ou repetidas deste opióide estão associadas a efeitos adversos dose dependentes, dentre eles, a depressão respiratória. No caso de pacientes submetidos a cirurgias de tórax, além da analgesia pós-operatória, devem também ser considerados como parâmetros relevantes a anestesia regional (intratecal) no intra-operatório, a qual pode contribuir para

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Takáo, Thales Baliero. "Classificação de dados cinéticos da inicialização da marcha utilizando redes neurais artificiais e máquinas de vetores de suporte." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5586.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-05-20T12:55:18Z No. of bitstreams: 2 Dissertação - Thales Baliero Takáo - 2015.pdf: 2798998 bytes, checksum: f90a7c928230875abd5873753316f766 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-05-20T12:56:48Z (GMT) No. of bitstreams: 2 Dissertação - Thales Baliero Takáo - 2015.pdf: 2798998 bytes, checksum: f90a7c928230875abd5873753316f766 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<

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Fujdiak, Radek. "Analýza a optimalizace datové komunikace pro telemetrické systémy v energetice." Doctoral thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-358408.

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Telemetry system, Optimisation, Sensoric networks, Smart Grid, Internet of Things, Sensors, Information security, Cryptography, Cryptography algorithms, Cryptosystem, Confidentiality, Integrity, Authentication, Data freshness, Non-Repudiation.

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Ou, Ju-Chi, and 歐茹琪. "The estimation of the area under multivariate ROC curve." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/10016159564156825199.

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碩士<br>國立成功大學<br>統計學系碩博士班<br>91<br>A statistical tool which is popular for describing the accuracy of diagnostic is the receive operating characteristic (ROC) curve. There has been an increased use of ROC curve for assessing the effectiveness of continuous diagnostic markers in distinguishing between diseased and healthy individuals. McClish (1989) recognized that the area under the ROC curve(AUROC) is a global measure of a test''s accuracy because it includes the entire range of false-positive rates from 0.0 to 1.0. In fact, it is possible that several diagnostic markers are used to detect

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Chen, Yu-Heng, and 陳禹衡. "Classification based on the area under ROC curve using genetic algorithm." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/20258668507253799889.

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碩士<br>國立臺灣科技大學<br>資訊管理系<br>104<br>Binary classification based on a feature vector is a long-standing problem. Linear discriminant analysis proposed by Fisher finds a linear combination of features such that the ratio of the variation between class to the variation within class is maximized. Similar to the linear discriminant analysis, we propose a linear combination of features such that the area under the receiver operating characteristic curve is maximized. The optimal linear combination is approximated by the genetic algorithm. Empirical results demonstrate substancial improvement on the cl

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Tau, Han-Wei, and 陶漢威. "Non-inferiority tests based on the partial area under ROC curve." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/25014094570157144564.

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碩士<br>國立中央大學<br>統計研究所<br>100<br>In this paper, we consider testing the non-inferiority of two medical diagnostic methods in a case-control study where each subject receiving the two different diagnostics produces correlated paired measurements. Note that it occurs often in practice that the marginal distributions of the measurements are right-skewed. Therefore, we first apply the power transformation to the paired data so that they would behave like the bivariate normal data. One parametric non-inferiority test is then implemented based on the transformed data. On the other hand, we suggest an

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Hsiao, Li-Cheng, and 蕭力誠. "Meta Analysis Method for Area under ROC Curve: Application to Glaucoma Diagnosis." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/87122944735184404646.

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碩士<br>淡江大學<br>數學學系碩士班<br>99<br>Meta-analysis is a quantitative weighted average method to combine the results of related but independent studies (usually drawn from the published literatures) and synthesize summaries and conclusions which may be used to evaluate the therapeutic effects and/or plain new study accordingly. The commonly used meta-analyses, dependent on the characteristic of data, are: the relative risk, odds ratio, and rates difference for binary data and effect size and meta-regression for normally distributed data. Meta-analysis for area under ROC curve (AUC), a commonly used m

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Ho, Chung-Yuan, and 何仲遠. "Meta Regression Analysis Method for Area under ROC Curve: Application to Glaucoma Diagnosis." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/92443545856026228649.

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碩士<br>淡江大學<br>數學學系碩士班<br>99<br>Meta-analysis is a quantitative weighted average method to combine the results of related but independent studies (usually drawn from the published literatures) and synthesize summaries and conclusions which may be used to evaluate the therapeutic effects and/or plain new study accordingly. The commonly used meta-analyses, dependent on the characteristic of data, are: the relative risk, odds ratio, and rates difference for binary data and effect size and meta-regression for normally distributed data. Meta-analysis for area under ROC curve (AUC), a commonly used m

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LEE, MING-HSUEH, and 李明學. "Performance of tests based on the area under the ROC curve for multireader diagnostic data." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/539yps.

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碩士<br>國立臺北大學<br>統計學系<br>106<br>The ROC (Receiver operating characteristic) curve is a measure for evaluating diagnostic reagents. The AUC (area under the ROC curve) is one of the most popular indices to evaluate the accuracy of the diagnostic reagents. X-ray films or MRI scans are often used to evaluate the status of cancer patients. Nevertheless, the outcome of these instruments requires professional physicians to determine. To ensure the accuracy of the instrument and avoid the possibility of reading bias from physicians, the outcome of these instruments is evaluated by several professional

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Dumont, Randall John. "Developing a limited sampling strategy for cyclosporine area under the curve monitering in lung transplant patients." Thesis, 2000. http://hdl.handle.net/2429/10604.

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This study developed a limited sampling strategy (LSS) to provide an estimate of cyclosporine (Neoral®) area-under-the-curve (AUC) in lung transplant recipients, a population for which a cyclosporine LSS has not yet been delineated. The predictive performance of the LSS, and other published ..LSS in other transplant types, was evaluated. Finally, the pharmacokinetic parameters of the lung transplant patients were calculated. Fourteen stable lung transplant patients (n = 7 male; n = 7 female) were entered into the study. Upon administration of a steady-state morning cyclosporine dose, blo

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Chang, Ya-Wen, and 張雅玟. "Comparing and correction for the method of estimating three kinds of time-dependent Area under the Receiver Operating Characteristic curve." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/80189855544715340582.

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碩士<br>國立中央大學<br>統計研究所<br>104<br>In the medical diagnosis, it usually recorded the measurements for covariates of patients with returning to clinic which also called time-dependent covariates. With the property of longitudinal data, it is not suitable for using traditional area under the Receiver Operating Characteristic curve (AUC) to distinguish the biomarkers for predicting ability of diseases. According to the methods in Heagerty & Zheng (2005), van Houwelingen, Putter (2012) and Blanche, Dartigues & Jacqmin-Gadda (2013), all can estimate time-dependent AUC. Since these three kinds of metho

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Chu, Su Peter. "Statistical Geocomputing: Spatial Outlier Detection in Precision Agriculture." Thesis, 2011. http://hdl.handle.net/10012/6347.

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The collection of crop yield data has become much easier with the introduction of technologies such as the Global Positioning System (GPS), ground-based yield sensors, and Geographic Information Systems (GIS). This explosive growth and widespread use of spatial data has challenged the ability to derive useful spatial knowledge. In addition, outlier detection as one important pre-processing step remains a challenge because the technique and the definition of spatial neighbourhood remain non-trivial, and the quantitative assessments of false positives, false negatives, and the concept of region

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"Sequencing Effects and Loss Aversion in a Delay Discounting Task." Master's thesis, 2018. http://hdl.handle.net/2286/R.I.49290.

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abstract: The attractiveness of a reward depends in part on the delay to its receipt, with more distant rewards generally being valued less than more proximate ones. The rate at which people discount the value of delayed rewards has been associated with a variety of clinically and socially relevant human behaviors. Thus, the accurate measurement of delay discounting rates is crucial to the study of mechanisms underlying behaviors such as risky sex, addiction, and gambling. In delay discounting tasks, participants make choices between two alternatives: one small amount of money delivered immedi

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Mistry, Pritesh, Daniel Neagu, Paul R. Trundle, and J. D. Vessey. "Using random forest and decision tree models for a new vehicle prediction approach in computational toxicology." 2015. http://hdl.handle.net/10454/7545.

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yes<br>Drug vehicles are chemical carriers that provide beneficial aid to the drugs they bear. Taking advantage of their favourable properties can potentially allow the safer use of drugs that are considered highly toxic. A means for vehicle selection without experimental trial would therefore be of benefit in saving time and money for the industry. Although machine learning is increasingly used in predictive toxicology, to our knowledge there is no reported work in using machine learning techniques to model drug-vehicle relationships for vehicle selection to minimise toxicity. In this paper w

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Lacombe, Shawn. "Interval and Continuous Exercise Elicit Equivalent Post- exercise Hypotension Despite Differences in Baroreflex Sensitivity and Heart Rate Variability." Thesis, 2010. http://hdl.handle.net/1807/24257.

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Equi-caloric bouts of interval (INT: 5x 2:2 min at 85 and 40% VO2max) and continuous (21 minutes at 60% VO2max) exercise were performed by 13 older prehypertensive males on separate days, at equivalent times of day, to assess the influence of exercise mode on post-exercise hypotension (PEH). Cardiovascular measures were collected for 30 min pre and 60 min post-exercise. PEH as measured by mean post-exercise systolic blood pressure (SBP) decrease, area under the SBP curve, and minimum SBP achieved, was equivalent after both conditions. SV was significantly reduced and HR was significantly eleva

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Lemos, Catarina Isabel Ferreira Miranda. "Seleção de genes diferencialmente expressos baseada em metodologia ROC (Receiver Operating Characteristic)." Master's thesis, 2017. http://hdl.handle.net/1822/56110.

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Dissertação de mestrado em Bioinformática<br>A análise da expressão genética é essencial para uma identificação da função dos genes e para a identificação destes quando relacionados com doenças. Para a realização de um estudo em larga escala de mudanças na expressão genética é necessário encontrar um método que o faça com precisão e exatidão. Desta forma, foi aqui incluída, uma análise pela tecnologia de microarrays, uma ferramenta importante no diagnóstico de doenças. A execução de um método que identificasse genes com regulação negativa e positiva e genes diferencialmente expressos sim

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Taha, Esraa. "Determination of plasma concentrations using LC/MS and pharmacokinetics of ofloxacin in patients with multi-drug resistant tuberculosis and in patients with multi-drug resistant tuberculosis coinfected with hiv." Thesis, 2009. http://hdl.handle.net/11394/3413.

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Magister Pharmaceuticae - MPharm<br>Many studies have investigated the pharmacokinetics of anti-tuberculosis drugs in patients infected with tuberculosis. However, little is known about the pharmacokinetics of the drugs that are used in the treatment of multi-drug resistant tuberculosis (MDRTB).Therefore, the objective of the present study was to investigate the steady state concentrations and the pharmacokinetics of ofloxacin, one of the drugs used in the treatment of MDR-TB in patients infected with MDR-TB and patients with MDR-TB co-infected with HIV Plasma samples were drawn at different

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Steyn, Hendrik Stefanus. "The use of effect sizes in credit rating models." Diss., 2014. http://hdl.handle.net/10500/18790.

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The aim of this thesis was to investigate the use of effect sizes to report the results of statistical credit rating models in a more practical way. Rating systems in the form of statistical probability models like logistic regression models are used to forecast the behaviour of clients and guide business in rating clients as “high” or “low” risk borrowers. Therefore, model results were reported in terms of statistical significance as well as business language (practical significance), which business experts can understand and interpret. In this thesis, statistical results were expressed

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Sarem, Sarem. "Limited sampling strategies for estimation of cyclosporine exposure in pediatric hematopoietic stem cell transplant recipients : methodological improvement and introduction of sampling time deviation analysis." Thèse, 2014. http://hdl.handle.net/1866/13046.

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