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Journal articles on the topic 'Areca quid'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Holla, Vidya A., L. K. Chatra, Prashanth Shenai, Devika Shetty, and Ashwini Baliga. "A Study to Analyze Different Patterns of Quid Usage among Subjects with Oral Submucous Fibrosis in Mangalore Population." Advances in Medicine 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/6124059.

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Aim and Objectives. Oral submucous fibrosis (OSF) is a potentially malignant disorder associated with the usage of areca nut. Usage of processed forms of areca nut is popular among the youth and its carcinogenic effects are not well known. Due to large immigrant population, various patterns of areca nut usage are seen. The aim of this study is to assess the various quid chewing patterns and their association with severity of OSF.Materials and Methods. A cross-sectional study was carried out with 250 cases clinically and histologically diagnosed as having OSF lesion that were selected and subje

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Gupta, PC, and CS Ray. "Epidemiology of Betel Quid Usage." Annals of the Academy of Medicine, Singapore 33, no. 4 Suppl (2004): 31S—36S. http://dx.doi.org/10.47102/annals-acadmedsg.v33n4p31s.

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Betel quid chewing is an ancient practice common in many countries of Asia and among migrated communities in Africa, Europe and North America. It enjoys complete social acceptance in many societies and is also popular among women. In its most basic form, betel quid consists of betel leaf (Piper betel), areca nut, the main psychoactive ingredient, and slaked lime (calcium hydroxide). Areca nut is said to be the fourth most commonly used psychoactive substance in the world, after caffeine, nicotine and alcohol. There are a great variety of ingredients and ways of preparing betel quid in differen

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Shrestha, A. "Approaches and Strategies for Habit Intervention in Smokeless Tobacco/Arecanut/ Betel Quid and Non-Starting." Journal of Global Oncology 4, Supplement 2 (2018): 20s. http://dx.doi.org/10.1200/jgo.18.45200.

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Background: Although adequate research has been conducted regarding smoking and smokeless tobacco, there is a dearth of research exploring reasons for chewing areca nut and betel-quid. Global epidemiology of areca nut and betel-quid shows distinct ethnic and cultural preferences. Areca nut is chewed for its psychological stimulating effects and perhaps, a medicinal value. To develop empirically supported treatments and to promote nonstarting, healthcare workers and researchers must first understand the reasons people engage in the behavior. Aim: To discuss evidence based approaches and strateg

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Aijaz, Amreen, Renu Nanwal, Sultan Abdulrahman Almalki, Vishwanath V. Jalli, Hemant Kumar Butolia, and Sugandha Arya. "Unveiling Mysteries of Quid-Induced Lichenoid Reactions: A Cross-Sectional Study." Journal of Pharmacy and Bioallied Sciences 16, Suppl 1 (2024): S317—S319. http://dx.doi.org/10.4103/jpbs.jpbs_507_23.

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ABSTRACT Lichenoid reactions occur exclusively in people who chew tobacco, areca nut, or both, in raw or any manufactured or processed form. The lesion is described as a lichen-planus–like lesion and is termed as quid-induced lichenoid reaction (QILR). In this cross-sectional study, amongst 935 quid consumers, 82 patients were diagnosed with QILR and it was seen that 65 patients used processed forms of tobacco and areca nut. Thereby, it could be concluded that QILR might occur because of flavors used in processing of tobacco and areca nut.

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Fatima, Nazish, Sidra Mohiuddin, Salim Hosein, and Mervyn Hosein. "Association of Carcinogenic Oral Habits with Oral Squamous Cell Carcinoma." Journal of the Pakistan Dental Association 30, no. 1 (2021): 29–33. http://dx.doi.org/10.25301/jpda.301.29.

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OBJECTIVE: To determine the association among betel nut, betel quid or smoking alone, and betel quid combined with smoking in subjects reporting with oral sub mucous fibrosis, oral submucous fibrosis with malignant transformation in to cancer and oral squamous cell carcinoma. METHODOLOGY: An analytical cross sectional, multi centric study of n = 1009 cases collected through non-probability convenience sampling. These n=1009 subjects were subdivided into four groups: group 1, who consumed areca nut only; group 2, who chewed betel quid along with areca nut; group 3, who used betel quid and smoke

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Mat Salleh, Noor Fadilatul Akmal, Ahmad Azlina, Masitah Hayati Harun, et al. "Cytotoxicity and Morphological Effects of Aqueous Areca Nut Crude Extract on L929 Fibroblast Cell Line." Asian Journal of Medicine and Biomedicine 4, no. 1 (2020): 34–41. http://dx.doi.org/10.37231/ajmb.2020.4.1.328.

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Betel quid chewing is a detrimental recreational habit amongst Asians and a risk factor for oral cancer. Arecoline, a component of areca nut (a major constituent of betel quid) is a known carcinogen. However, the effect of areca nut crude extract is not much studied. To evaluate the cytotoxicity and morphologic effects of areca nut aqueous extract on mouse fibroblast cell line (L929). Dried raw areca nut obtained from a local market in Kota Bharu, Kelantan was prepared and suspended in DMEM (Dulbecco’s Modified Eagle’s medium), prior to serial dilution of 1.56, 0.781, 0.39, 0.195, 0.0976, 0.04

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Kister, Mateusz P., Katarzyna Borowska, Karolina A. Kister, Agnieszka Wojtowicz, and Barbara Jodlowska-Jedrych. "Risks associated with betel quid chewing." Current Issues in Pharmacy and Medical Sciences 30, no. 1 (2017): 24–26. http://dx.doi.org/10.1515/cipms-2017-0005.

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Abstract Betel quid is one of the most commonly used psychoactive substances in the world, especially among Asian communities, just after caffeine, nicotine and alcohol. The mixture that is chewed usually contains betel leaves, areca nut and slaked lime, nonetheless, its ingredients and the preparation manner tend to vary. Areca nut contains four main alkaloids - arecoline, arecaidyne, guvacine and guvacoline that are responsible for its psychoactive effects. The act of betel chewing might have a negative impact on an overall health and can cause pathological lesions or diseases to develop and

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Tak, J., N. Gupta, and R. Bali. "Oral Submucous Fibrosis: A Review Article on Etiopathogenesis." Kathmandu University Medical Journal 12, no. 2 (2015): 153–56. http://dx.doi.org/10.3126/kumj.v12i2.13666.

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Areca quid chewing related oral mucosal lesions are potential hazard to a large population worldwide. Commercially freeze dried products such as pan masala, guthka and mawa have high concentration of areca nut per chew and appear to cause OSMF more rapidly than by self prepared conventional betel quid that contain smaller amounts of areca nut. The basic constituent of areca nut is either raw or dried or boiled or baked. Diverse agents including lime, tobacco, catechu, cloves, saffron and leaf of piper betel leaves may form a part of formulation. Many of the undesirable aspects of areca nut hav

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Bhat, S. Keshava, and Sukesh Bhat. "How Areca Nut Chewing Was Made the Cause for Oral Submucous Fibrosis and Oral Cancer: An Analysis." International Journal of Health Sciences and Research 15, no. 6 (2025): 262–70. https://doi.org/10.52403/ijhsr.20250633.

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Areca nut is the nut or seed of Areca catechu palm. This nut is mostly used for chewing because of its immense beneficial effects. The antiquity of its chewing goes back to more than thousand years. Of late, several researchers claimed areca nut chewing as the cause for oral submucous fibrosis and oral cancer. But in most of such research papers it was observed that the chewing substance was not authenticated by any experts in plant science leading to wrong identification of the chewing material. Consequently, the chewing mixtures such as betel quid, pan masala, gutkha, etc were wrongly quoted

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Banerjee, Subhrajit. "An Account of Areca Nut Uses and Oral Health Damages from An Indian Perspective." BOHR International Journal of Current research in Dentistry 1, no. 1 (2022): 54–63. http://dx.doi.org/10.54646/bijcrid.011.

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There is a perception in India that packaged paan masala and betel quid (BQ) with areca nut loosely called paan supari both being devoid of tobacco are not carcinogenic. This article intends to be an awareness initiative against this notion. It focuses on the use of areca nuts in various forms. An understanding is necessary for the identification of components of gutka, various forms of BQ, and paan masala wherein areca nut is used. Areca nut consumption damages oral health and leads to the development of oral submucous fibrosis (OSF). OSF is used as an umbrella term for depicting all potentia

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Banerjee, Subhrajit. "An account of areca nut uses and oral health damages from an Indian perspective." BOHR International Journal of Current Research in Dentistry 2, no. 1 (2023): 1–12. http://dx.doi.org/10.54646/bijcrid.2023.11.

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There is a perception in India that packaged paan masala and betel quid (BQ) with areca nut loosely called paan supari both being devoid of tobacco are not carcinogenic. This article intends to be an awareness initiative against this notion. It focuses on the use of areca nuts in various forms. An understanding is necessary for the identification of components of gutka, various forms of BQ, and paan masala wherein areca nut is used. Areca nut consumption damages oral health and leads to the development of oral submucous fibrosis (OSF). OSF is used as an umbrella term for depicting all potentia

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12

de la Monte, Suzanne M., Natalia Moriel, Amy Lin, et al. "Betel Quid Health Risks of Insulin Resistance Diseases in Poor Young South Asian Native and Immigrant Populations." International Journal of Environmental Research and Public Health 17, no. 18 (2020): 6690. http://dx.doi.org/10.3390/ijerph17186690.

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Betel quid, traditionally prepared with areca nut, betel leaf, and slaked lime, has been consumed for thousands of years, mainly in the form of chewing. Originally used for cultural, medicinal, and ceremonial purposes mainly in South Asian countries, its use has recently spread across the globe due to its psychoactive, euphoric, and aphrodisiac properties. Now it is widely used as a social lubricant and source of financial profit. Unfortunately, the profit motive has led to high rates of habitual consumption with eventual conversion to addiction among young girls and boys. Moreover, the worris

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Gupta, Juhi, and Vipul Jain. "Knowledge, attitude, and practices of areca nut and betel quid chewing among the adult population – A questionnaire-based cross-sectional study." SRM Journal of Research in Dental Sciences 15, no. 1 (2024): 15–21. http://dx.doi.org/10.4103/srmjrds.srmjrds_127_23.

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ABSTRACT Background: The use of areca nut also known as supari or chaali is an age-old tradition and very popular in people living in South Asian countries. However, in general, people know very little about its ill effects. Aims: This study aimed to examine knowledge, attitudes, and practices regarding the health risks associated with chewing areca nuts and betel quid among the adult population and to evaluate the knowledge about its possible role as a contributing factor in oral cancer among the adult population. Materials and Methods: The unicentric cross-sectional survey was conducted on 1

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Aniket, Adhikari, and De Madhusnata. "Study of Glutathione Peroxidase GPX Activity Among Betel Quid Chewers of Indian Population." International Journal of Trend in Scientific Research and Development 3, no. 3 (2019): 70–73. https://doi.org/10.31142/ijtsrd21619.

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Introduction Betel quid BQ chewing, a habit practiced in Eastern and North Eastern part of India, has known to be associated with cancer of the oral or buccal cavity. BQ is also one of the common mood elevating substances among Indian population. The BQ is a mixture of areca nut Areca catechu , catechu Acacia catechu and slaked lime calcium oxide and calcium hydroxide wrapped in a betel leaf Piper betel .BQ products have been classified by the International Agency for Research on Cancer IARC as group I human carcinogens . Glutathione peroxidise GPx , one of the major enzymatic antioxidant defe

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Chuang, Hui-Ching, Ming-Hsien Tsai, Yu-Tsai Lin, Ming-Huei Chou, Kun-Lin Yang, and Chih-Yen Chien. "Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer." Technology in Cancer Research & Treatment 21 (January 2022): 153303382211468. http://dx.doi.org/10.1177/15330338221146870.

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The major predisposing factors of developing oral cancer include smoking, alcohol drinking, and betel quid chewing. Betel quid chewing could cause the abrasion and damage of oral mucosa by crude fibers, chemical insults by additive slaked lime, and arecoline from areca nut. These would lead to the local consequence of oral submucosal fibrosis, which is regarded clinically as a precancer lesion and a major cause of trismus. In addition, the components and additives in betel quid contain chemical toxins and carcinogens, which would further affect the oral mucosa and gradually develop a malignanc

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Reza Agustina, Amirah Mujahidah, and Titiek Berniyanti. "Betel nut chewing effects on the incidence of periodontitis." World Journal of Advanced Research and Reviews 23, no. 3 (2024): 540–43. http://dx.doi.org/10.30574/wjarr.2024.23.3.2606.

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Background: Betel quid chewing, a common cultural practice in various parts of Asia, has been associated with numerous oral health issues, including periodontitis. Betel quid chewing, which involves the consumption of a mixture of areca nut, lime, betel leaf, and sometimes tobacco, is a common practice in several Asian countries, including Indonesia. Several studies have indicated a connection between this habit and various oral health problems, including periodontitis, a chronic inflammatory condition affecting the supporting tissues of the teeth. This systematic literature review aims to exp

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Reza, Agustina, Mujahidah Amirah, and Berniyanti Titiek. "Betel nut chewing effects on the incidence of periodontitis." World Journal of Advanced Research and Reviews 23, no. 3 (2024): 540–43. https://doi.org/10.5281/zenodo.14928803.

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<strong>Background: </strong>Betel quid chewing, a common cultural practice in various parts of Asia, has been associated with numerous oral health issues, including periodontitis. Betel quid chewing, which involves the consumption of a mixture of areca nut, lime, betel leaf, and sometimes tobacco, is a common practice in several Asian countries, including Indonesia. Several studies have indicated a connection between this habit and various oral health problems, including periodontitis, a chronic inflammatory condition affecting the supporting tissues of the teeth. This systematic literat

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Adhikari, Aniket, and Madhusnata De. "Study of Superoxide Dismutase (SOD) Activity Among Betel Quid Chewers of Indian Population." Cancer Research and Cellular Therapeutics 6, no. 3 (2022): 01–03. http://dx.doi.org/10.31579/2640-1053/117.

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Introduction: Betel quid (BQ) chewing, a habit practiced in Eastern and North Eastern part of India, has known to be associated with cancer of the oral or buccal cavity. BQ is also one of the common mood elevating substances among Indian population. The BQ is a mixture of areca nut (Areca catechu), catechu (Acacia catechu) and slaked lime (calcium oxide and calcium hydroxide) wrapped in a betel leaf (Piper betel). BQ products have been classified by the International Agency for Research on Cancer (IARC) as group I human carcinogens . Superoxide Dismutase (SOD), one of the major enzymatic antio

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Sznajder, Kristin K., Mary K. Shenk, Nurul Alam, et al. "Betel quid use is associated with anemia among both men and women in Matlab, Bangladesh." PLOS Global Public Health 3, no. 6 (2023): e0001677. http://dx.doi.org/10.1371/journal.pgph.0001677.

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Anemia accounts for 8.8% of total disability burden worldwide. Betel quid use among pregnant women has been found to increase anemia risk. Betel quid is prepared by wrapping the betel (or areca) nut, with spices and other additions, in betel or tobacco leaf and it is chewed or placed in the mouth. We explored the association between betel quid use and anemia among men and non-pregnant women. We collected data from a random sample of women and their husbands in Matlab, Bangladesh. Participants reported their current betel quid use and individual characteristics. We assessed hemoglobin (a biomar

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A. Faden, Asma’a. "Evaluation of Antibacterial Activities of Aqueous and Methanolic Extracts of Areca catechu against Some Opportunistic Oral Bacteria." Biosciences, Biotechnology Research Asia 15, no. 3 (2018): 655–59. http://dx.doi.org/10.13005/bbra/2673.

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The aqueous and methanolic extracts of Areca catechu seeds (known as areca nut: a component of a betel quid, where their chewing habitis a popular cultural tradition in some South East Asian countries used as an oral cleanser) have shown some antimicrobial potentials against some oral bacteria which are capable of causing opportunistic infections in the mouth. The objective of this study is to detect the antibacterial activities of aqueous and methanolic extracts of Areca catechu against Escherichia coli and Staphylococcus aureus.Manystudies showed different antibacterial activity, depending o

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Bhat, Jeddu Ganapathi, Manorama G. Bhat, S. Keshava Bhat, Sukesh Bhat, and Gajanand R. Pujari. "ANTICANCER PROPERTY OF AN AYURVEDIC POLYHERBAL PREPARATION CHIEFLY CONTAINING ARECA NUT AND BETEL LEAF." International Journal of Research in Ayurveda and Pharmacy 14, no. 1 (2023): 13–16. http://dx.doi.org/10.7897/2277-4343.14015.

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Background: Areca nut, the nut of the areca palm (Areca catechu L.) and the leaf of betel vine (Piper betle L.) are the two inevitable ingredients of the common chewing mixture popularly known as betel quid. Both traditional and modern research findings proved that these two plant products have many medicinal values, including anticancer properties. With this information, we formulated a polyherbal preparation chiefly containing these two plant products and evaluated its anticancer efficacy on the specific cancer cell line. Methods: The polyherbal preparation called ‘Pugasaram’ was prepared us

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Lai, Ching-Shiun, Tien-Yu Shieh, Yi-Hsin Connie Yang, Mian-Yoon Chong, Hsin-Chia Hung, and Chi-Cheng Tsai. "Factors associated with quitting areca (betel) quid chewing." Community Dentistry and Oral Epidemiology 34, no. 6 (2006): 467–74. http://dx.doi.org/10.1111/j.1600-0528.2006.00305.x.

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Lubis, Indri, Ameta Primasari, and Sayuti Hasibuan. "ORAL POTENTIALLY MALIGNANT DISORDERS ASSOCIATED WITH BETEL QUID CHEWING HABIT IN SAMOSIR ISLAND, NORTH SUMATRA INDONESIA." Dentika Dental Journal 20, no. 2 (2017): 72–79. http://dx.doi.org/10.32734/dentika.v20i2.997.

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Oral potentially malignant disorders have been associated with a betel quid chewing habit. To date, betel quid chewing has a major social and cultural role in the society of Samosir Island, North Sumatra, Indonesia. The purpose of the present study was to evaluate the occurrence of oral potentially malignant disorders associated with the habit of betel quid chewing in the society of Samosir Island, North Sumatra, Indonesia. This case-control study was conducted on all betel quid chewers in the working area of the Ambarita Public Health Centre in Samosir Regency, North Sumatra, Indonesia. All s

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Yanduri, Sarita, Veerendra B. Kumar, S. Suma, and MG Madhura. "Lichenoid Features and Fibrosis: Coexistence in Quid-induced Oral Lesions." Journal of Contemporary Dental Practice 16, no. 5 (2015): 389–93. http://dx.doi.org/10.5005/jp-journals-10024-1695.

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ABSTRACT Background Oral submucous fibrosis (OSF) and quid associated oral lichenoid lesions (QOLL) are caused because of areca nut chewing and both show very characteristic histological changes. The present study aims to determine the histopathological presence of lichenoid features in cases of OSF as well as to determine the presence of fibrosis in cases of QOLL. Materials and methods The study involved the retrospective analysis of hematoxylin and eosin stained slides of OSF (n = 50) and QOLL (n = 16). Results Seven cases of OSF revealed histopathological features of lichenoid reaction and

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Diwan, Prerna, Mohit Nirwan, Mayank Bahuguna, Shashi Prabha Kumari, James Wahlang, and Rakesh Kumar Gupta. "Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic Intervention." Pathogens 12, no. 8 (2023): 996. http://dx.doi.org/10.3390/pathogens12080996.

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Areca nut and slaked lime, with or without tobacco wrapped in Piper betle leaf, prepared as betel quid, is extensively consumed as a masticatory product in many countries across the world. Betel Quid can promote the malignant transformation of oral lesions as well as trigger benign cellular and molecular changes. In the oral cavity, it causes changes at the compositional level in oral microbiota called dysbiosis. This dysbiosis may play an important role in Oral Cancer in betel quid chewers. The abnormal presence and increase of bacteria Fusobacterium nucleatum, Capnocytophaga gingivalis, Prev

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Zhang, Pangzhen, Elizabeth Fitriana Sari, Michael J. McCullough, and Nicola Cirillo. "Metabolomic Profile of Indonesian Betel Quids." Biomolecules 12, no. 10 (2022): 1469. http://dx.doi.org/10.3390/biom12101469.

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Consumption of areca nut alone, or in the form of betel quid (BQ), has negative health effects and is carcinogenic to humans. Indonesia is one of the largest producers of areca nuts worldwide, yet little is known about the biomolecular composition of Indonesian areca nuts and BQs. We have recently shown that phenolic and alkaloid content of Indonesian BQs exhibits distinct geographical differences. Here, we profiled for the first time the metabolomics of BQ constituents from four regions of Indonesia using non-targeted gas chromatography–mass spectrometry (GC–MS) analysis. In addition to well-

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Marzan, Abdullah, Md Hasan, Md Islam, et al. "Impact of Betel quid on hyperglycaemia among diabetes patients in Bangladesh." Journal of Advanced Biotechnology and Experimental Therapeutics 7, no. 3 (2024): 460. http://dx.doi.org/10.5455/jabet.2024.d40.

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This study explores the impact of betel quid (BQ) chewing on hyperglycaemia among diabetic patients in northeastern Bangladesh. BQ, a prevalent social habit in Asia, is often used without awareness of its harmful effects. We focus on the role of areca nut, a key addictive component in BQ, in influencing hyperglycaemia. Random blood glucose (RBG) tests were conducted on 961 diabetic patients, alongside lifestyle data, from August 2018 to February 2019 at Sylhet Diabetic Hospital, Bangladesh. Statistical analyses, including t-tests, Analysis of the variance (ANOVA), Fisher's exact test, and Mult

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Yen, C. F., C. H. Ko, J. Y. Yen, and S. J. Liu. "Areca quid chewing and methamphetamine use in Taiwanese adolescents." Public Health 119, no. 1 (2005): 50–54. http://dx.doi.org/10.1016/j.puhe.2004.02.002.

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Sharma, Dinesh C. "Betel quid and areca nut are carcinogenic without tobacco." Lancet Oncology 4, no. 10 (2003): 587. http://dx.doi.org/10.1016/s1470-2045(03)01229-4.

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Li, Shih-Ming, Jehn-Shyun Huang, and Shu-Chen Wu. "The outcome expectancy model for areca-quid chewing behavior." Addictive Behaviors 32, no. 3 (2007): 628–33. http://dx.doi.org/10.1016/j.addbeh.2006.06.002.

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Das, Anita, Elizabeth Orlan, Kalina Duncan, et al. "Areca Nut and Betel Quid Control Interventions: Halting the Epidemic." Substance Use & Misuse 55, no. 9 (2020): 1552–59. http://dx.doi.org/10.1080/10826084.2019.1686022.

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CONSTANTIN, MARIAN. "Lifestyle features as co-factors in head and neck cancer development." Romanian Biotechnological Letters 28, no. 2/2023 (2023): 3950–58. http://dx.doi.org/10.25083/rbl/28.2/3950.3958.

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Ranked sixth most prevalent worldwide, head and neck cancers (HNCs) a􀵵ect an increasing number of people. Several factors contribute to their occurrence, including genetic and epigenetic aberrations and lifestyle factors, including heavy smoking, alcohol consumption, chewing betel quid (Areca nuts), poor oral hygiene, consumption of pro-in􀃀ammatory foods, inhalation of chemical compounds, asbestos dust, and infections with HPV (human papillomavirus) and EBV (Epstein-Barr virus). Often diagnosed in advanced stages, they have a mortality rate of about 50% at 5 years and pose a serious threat to

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Kalwagadda, Sowjanya, Anusha Vaddi, Rakesh Kumar Manne, Praveen Kumar Mudda, and Joshna Rani Premara. "Ultrasonographic evaluation of masseter muscle thickness in chronic areca nut/ tobacco chewers and oral submucous fibrosis patients." Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology 9, no. 1 (2023): 41–46. http://dx.doi.org/10.18231/j.jooo.2023.009.

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The benign increase in the size of the masseter muscle is referred to as masseter muscle hypertrophy (MMH). It may affect unilaterally or bilaterally. Frequent and prolonged chewing of areca nut, betel quid, and tobacco exerts undue pressure on muscles of mastication. This may lead to hypertrophy of masticatory muscles, especially the masseter. The objective of the study is to evaluate the difference in cross-sectional thickness of masseter muscle at rest and at maximum clenching position using USG in chronic areca nut/tobacco chewers, OSMF patients, and the control group.The study included 20

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Sari, Elizabeth Fitriana, Ali I. Mohammed, Antonio Celentano, Michael John McCullough, and Nicola Cirillo. "Cytotoxic Effects of Indonesian Betel Quid Components on Oral Keratinocytes and Fibroblasts." BioChem 3, no. 4 (2023): 153–69. http://dx.doi.org/10.3390/biochem3040011.

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A betel quid (BQ) chewing habit has been strongly associated with the development of several oral mucosal diseases. In order to investigate whether individual components of BQ mixtures have distinct physio-pathological effects on oral mucosal cells, we examined the impact of areca nut (AN), Piper betle leaf (Leaf), Piper betle stem inflorescence (SI), areca husk (Husk) and the complete BQ mixture on the growth of oral keratinocytes (OKF-6) and primary oral fibroblasts (MMF-1). Based on their known chemical properties, we selected BQ samples from Banda Aceh (BA) and West Papua (WP) regions for

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ZOTE, LALRINAWMA, BOMNGAM KAKKI, ANANYA BURAGOHAIN, et al. "Essential and presumably contaminating trace elements in Indian Areca (Areca catechu L.) nut and their potential health effect." Romanian Reports in Physics 76, no. 2 (2025): 701. https://doi.org/10.59277/romrepphys.2025.77.701.

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Betel quid (BQ) containing Areca catehu L. nut kernel, Piper betle L. leaves and slaked lime are chewed together for their stimulant and mild addictive effects. The mass fractions of Mg, Na, Si, K, Ca, and Cl, together with some Presumably Contaminating Elements (PCE) such as Al, Mn, Co, Ni, Cu, Zn, As and Sb in areca nuts (AN) kernel and husk, collected from 14 plantations located in Northeastern India and the Republic of the Union of Myanmar plantations, were determined by Instrumental Neutron Activation Analysis (INAA). The INAA demonstrated that elemental compositions of AN kernel and husk

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Porcheri, Cristina, and Thimios A. Mitsiadis. "New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas." Cancers 13, no. 21 (2021): 5515. http://dx.doi.org/10.3390/cancers13215515.

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Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent types of cancer with a lethal outcome in half of the diagnosed cases. Mostly, HNSCC develops in the oral cavity, and its development is associated with tobacco and areca nut/betel quid usage, alcohol consumption, and HPV infection. Oral squamous cell carcinoma, as other head and neck cancers, presents a high degree of intratumor heterogeneity, which makes their treatment difficult, and directly correlates with drug resistance. Since the classical treatments for HNSCC oftentimes do not resolve the clinical picture, there

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Giri, Dhirendra K., P. Kundapur, K. M. Bhat, and I. K. Maharjan. "Betel Nut Chewing Associated With Severe Periodontitis." Health Renaissance 12, no. 1 (2015): 57–60. http://dx.doi.org/10.3126/hren.v12i1.11990.

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Betel quid chewing has been in practice among people in many Asian countries since ages. It is the most widely used psychoactive substance and an important environmental risk factor for development of oral premalignant lesions and cancer. Arecoline, the major alkaloid of areca nut, has been known to cause cytotoxicity and genotoxicity in mammalian cells in vivo and in vitro and even contributes to carcinogenicity. It also increases the risk and severity of periodontal disease. This paper presents a case of betel nut chewing associated with severe periodontitis in a 32 year old male patient.DOI

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Sahitha, R. "Effects of Smokeless Tobacco, Betel Quid and Areca Nut on Oral Mucosa." IOSR Journal of Dental and Medical Sciences 13, no. 2 (2014): 08–11. http://dx.doi.org/10.9790/0853-13210811.

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Kumar, Ajay, Adit Srivastava, Neha Sah, et al. "Management of oral sub-mucous fibrosis using platelet-rich plasma and triamcinolone with hyaluronidase." Bioinformation 21, no. 04 (2025): 599–605. https://doi.org/10.6026/973206300210599.

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Oral Submucous Fibrosis (OSMF) is a chronic, progressive and potentially malignant disorder of the oral mucosa, primarily associated with betel quid and areca nut chewing. Therefore, it is of interest to compare the efficacy of intralesional Platelet-Rich Plasma (PRP) versus triamcinolone acetonide with hyaluronidase in the treatment of oral submucous fibrosis. This is a randomized clinical trial was conducted at the unit of oral medicine and radiology, Faculty of Dental Sciences, IMS, Banaras Hindu University (BHU), Varanasi. Patients diagnosed with grade II and III oral submucous fibrosis pa

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Kloee Titu Eki, Ardent, and Christina Ngadilah. "Excessive Deadly Addiction Chewing Betel Quid as a double burden, For Poverty Community Kupang Regency, West Timor." Eduvest - Journal of Universal Studies 3, no. 12 (2023): 2107–18. http://dx.doi.org/10.59188/eduvest.v3i12.978.

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People's lives in developed countries are indeed in contrast to developing countries as well as in terms of behavior. Betel nut is estimated to be consumed by 10% -25% of the world's population. In East Nusa Tenggara, Indonesia, almost the entire population (21) districts consume betel nut, including the elderly, young people and school children, even those who are still studying in Early Education. About 80% of the population of Kupang Regency, West Timor, consume betel nut.even though the district Kupang is mostly poor. Possible Hazards in areca nut mixed with various other ingredients such

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Jayaswal, Abhishek, Saurabh Goel, Kavita Verma, Srujal Jivrajani, and Barkha Makhijani. "Prevalence of oral submucous fibrosis linking with Areca Nut usage among Indians." Bioinformation 20, no. 7 (2024): 751–53. http://dx.doi.org/10.6026/973206300200751.

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The prevalence of oral submucous fibrosis amongst population of Southern Rajasthan is of interest to dentists. Hence, a cross sectional study had been conducted on 3548 patients from 18-60 years age group who visited the Department of the Oral Medicine and Radiology, Pacific Dental College and Research Centre, Bedla, Udaipur was completed. They were subjected to thorough case history related to quid habit in arecanut (Areca catechu L.) form and to diagnose OSMF clinically. 1645 processed form of arecanut users were identified. The prevalence of arecanut chewers in study population has been rep

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Zhang, Pangzhen, Nathaniel Quan En Chua, Simon Dang, et al. "Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents—Does Fibroblast Senescence Play a Role?" International Journal of Molecular Sciences 23, no. 3 (2022): 1637. http://dx.doi.org/10.3390/ijms23031637.

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Betel quid (BQ) is a package of mixed constituents that is chewed by more than 600 million people worldwide, particularly in Asia. The formulation of BQ depends on a variety of factors but typically includes areca nut, betel leaf, and slaked lime and may or may not contain tobacco. BQ chewing is strongly associated with the development of potentially malignant and malignant diseases of the mouth such as oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC), respectively. We have shown recently that the constituents of BQ vary geographically and that the capacity to induce dise

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Chen, Chiu-Lan, Chin-Wen Chi, and Tsung-Yun Liu. "HYDROXYL RADICAL FORMATION AND OXIDATIVE DNA DAMAGE INDUCED BY ARECA QUID IN VIVO." Journal of Toxicology and Environmental Health, Part A 65, no. 3-4 (2002): 327–36. http://dx.doi.org/10.1080/15287390252800909.

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Chen, Ping-Ho, Chi-Cheng Tsai, Ying-Chu Lin, et al. "Ingredients Contribute to Variation in Production of Reactive Oxygen Species by Areca Quid." Journal of Toxicology and Environmental Health, Part A 69, no. 11 (2006): 1055–69. http://dx.doi.org/10.1080/15287390500360224.

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Tsai, C.-H., S.-F. Yang, S.-S. Lee, and Y.-C. Chang. "Augmented heme oxygenase-1 expression in areca quid chewing-associated oral submucous fibrosis." Oral Diseases 15, no. 4 (2009): 281–86. http://dx.doi.org/10.1111/j.1601-0825.2009.01523.x.

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Chen, M. "Evaluation of a self-rating screening test for areca quid abusers in Taiwan." Public Health 116, no. 4 (2002): 195–200. http://dx.doi.org/10.1016/s0033-3506(02)90066-1.

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Mehrtash, Hedieh, Kalina Duncan, Mark Parascandola, et al. "Defining a global research and policy agenda for betel quid and areca nut." Lancet Oncology 18, no. 12 (2017): e767-e775. http://dx.doi.org/10.1016/s1470-2045(17)30460-6.

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Huang, Jehn-Shyun, Tse-Jung Ho, Chun-Pin Chiang, Sang-Heng Kok, Ying-Shiung Kuo, and Mark Yen-Ping Kuo. "MDM2 expression in areca quid chewing-associated oral squamous cell carcinomas in Taiwan." Journal of Oral Pathology & Medicine 30, no. 1 (2001): 53–58. http://dx.doi.org/10.1034/j.1600-0714.2001.300109.x.

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Bombale, Namrata. "Current Approaches in the Treatment and Prevention of Oral Submucous Fibrosis: A Chronic Disease Perspective." Journal of Internal Medicine and Pharmacology (JIMP) 1, no. 02 (2024): 44–50. https://doi.org/10.61920/jimp.v1i02.26.

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Oral Submucous Fibrosis (OSMF) is a chronic, progressive, and scarring disease of the oral cavity, often extending to the pharynx and upper esophagus, primarily caused by the chewing of areca nuts, betel quid, ghutka, mawa, and similar substances. This review highlights the potential role of antioxidants such as lycopene, curcumin, spirulina, and β-carotene in managing OSMF. It explores the synergistic effects of these antioxidants in combating oxidative stress and proposes the development of buccal oral patches as a novel therapeutic approach. These patches are designed to adhere to the affec

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Johnson, N. "Quantifying the Immense Burden of OPMDS and of Oral Cancer in South Asia: Time for Action." Journal of Global Oncology 4, Supplement 2 (2018): 125s. http://dx.doi.org/10.1200/jgo.18.20600.

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Background: Cancer of head and neck is sixth most common malignancy worldwide https://www.ncbi.nlm.nih.gov/pubmed/27245686 . ∼90% are squamous cell carcinomas [HNSCC]. Of H&N sites, mouth is most common [∼300,373 cases pa, cf oropharynx ∼142,387; larynx ∼156,877; nasopharynx 86,691]. Across south Asia, cancer of lip & mouth [oral cancer: OSCC] is a serious public health problem. In many, it is the most common cancer among men, 5th/6th in women, second overall. Five year survival rates are < 50%. Treatment is devastating. It is difficult to get authorities and public to recognize the

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