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Pfefferkorn, Oliver. "PREDIGT, ANDACHTSBUCH UND GEBETBUCH BEl JOHANN ARNDT." Daphnis 28, no. 2 (March 30, 1999): 347–85. http://dx.doi.org/10.1163/18796583-90000668.
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Hannak, Kristine, and Andrew Weeks. "Sebastian Franck, Johann Arndt, and the Varieties of Religious Dissent." Daphnis 48, no. 1-2 (March 19, 2020): 319–27. http://dx.doi.org/10.1163/18796583-04801005.
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Sebastian Franck and Johann Arndt must be included among those dissenters inspired by the Lutheran Reformation who pursued reforming objectives that went beyond theology and devotion. Franck and Arndt are contrasting figures who reveal the breadth of the movement. The former was a radical and rebel whose studies included history and humanism; the latter turned to Paracelsus and strove to work within Lutheran institutions and retain the pastoral authority which Franck cast aside. Both rejected theological dispute and religiously motivated violence; and both were decisively attracted to the same mystical texts. Both exercised remarkable influence in their day and belatedly in different later periods.
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Mattes, Mark. "Johann Arndt: A prophet of Lutheran Pietism by Daniel Van Voorhis." Lutheran Quarterly 33, no. 3 (2019): 358–60. http://dx.doi.org/10.1353/lut.2019.0074.
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PARK, Jeung-Keun. "JOHANN ARNDT IN KOREA : DIE KOREANISCHE ÜBERSETZUNG DES WAHREN CHRISTENTUMS(1605-1610)." KOREA PRESBYTERIAN JOURNAL OF THEOLOGY 51, no. 4 (November 30, 2019): 73–91. http://dx.doi.org/10.15757/kpjt.2019.51.4.004.
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Grainger, Brett Malcolm. "Vital Nature and Vital Piety: Johann Arndt and the Evangelical Vitalism of Cotton Mather." Church History 81, no. 4 (December 2012): 852–72. http://dx.doi.org/10.1017/s0009640712001928.
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Despite a surfeit of studies recognizing Cotton Mather's support for a range of alchemical and occult practices, historians have yet to integrate these occult activities with Mather's religious and scientific thought as a whole. I argue that we can bring clarity to Mather's engagement with the occult by refracting it through his reverence for Lutheran Pietist Johann Arndt, whose writings, especiallyVier bucher vom wahren Christentum (Four Books of True Christianity), offer a key to Mather's employment of hermetic materials in his major works of natural philosophy. Through analysis ofThe Christian PhilosopherandThe Angel of Bethesda,as well as Mather's private writings, I suggest that Mather's cosmology was vitalistic in ways not previously acknowledged by historians. This view of creation as dynamic, enchanted, and marked by divine signatures—evidenced most clearly in Mather's concept of thenishmath-chajim—helped Mather reconcile the new science, Puritan covenant theology, and alchemical traditions descending from Paracelsus. By positing a divine, dynamic presence in nature, Mather retained an orthodox view of God as sovereign and transcendent while intimately engaged in a process of cosmic redemption, slowly transmuting the base matter of a fallen creation into a new heaven and new earth.
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Classen, Albrecht, and Elke Axmacher. "Johann Arndt und Paul Gerhardt. Studien zur Theologie, Frömmigkeit und geistlichen Dichtung des 17. Jahrhunderts." Lied und populäre Kultur / Song and Popular Culture 47 (2002): 207. http://dx.doi.org/10.2307/3595192.
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Fajt, Anita. "At the Crossroad of Confessions." Central European Cultures 1, no. 2 (December 20, 2021): 3–28. http://dx.doi.org/10.47075/cec.2021-2.01.
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The focus of my study is a mid-seventeenth-century Latin manuscript prayer book. Its most basic characteristics should attract the attention of scholars of the period since it was compiled by a Lutheran married couple from Prešov for their individual religious practice. In examining the prayer book, I was able to identify the basic source of the manuscript, which was previously unknown to researchers: the compendium of the German Lutheran author Philipp Kegel. The manuscript follows the structure of Kegel’s volume and also extracts a number of texts from the German author’s work, which mainly collects the writings of medieval church fathers. In addition to Kegel, I have also been able to identify a few other sources; mainly the writings of Lutheran authors from Germany (Johann Arndt, Johann Gerhardt, Johann Rist, and Johann Michael Dilherr). I give a description of the physical characteristics of the manuscript, its illustrations, the hymns that accompany the prayers, and the copying hands. I will also attempt to identify the latter more precisely. The first compilers of the manuscript were Andreas Glosius and his wife Catharina Musoniana from Prešov. I also organize the biographical data we have about their life and will correct the certainly erroneous provenance of Andreas Glosius, whose name appears in the context of several important contemporary manuscripts, including the gradual of Prešov. In the last part of my paper, I will also show how well known and popular Philipp Kegel’s work was in the early modern Kingdom of Hungary. This is necessary because, although the data show that there was a very lively reception of Philipp Kegel’s work in Hungary, previous scholars have only tangentially dealt with the Hungarian presence of his work.
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Strungytė-Liugienė, Inga. "Johanno Arndto Rojaus Darǯelio maldų redagavimo istorija (1807–1817)." Archivum Lithuanicum, no. 23 (December 31, 2021): 137–60. http://dx.doi.org/10.33918/26692449-23005.
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The History of Revisions of Prayers in Johann Arndt’s ROJAUS DARǮELIS (1807 – 1817) S u m m a r y Johann Arndt (1555–1621), the German theologian and next-generation religious reformer is the author of the uniquely successful prayer book titled Paradiesgärtlein (Magdeburg,1612). The first known Lithuanian translation of Arndt’s Paradiesgärtlein appeared in early 19th century in Prussian Lithuanian. It was published in 1807 by the widow of Gottlieb Lebrecht Hartung, a printer from Königsberg. This article aims to reveal the history of revisions of six prayers from Johann Arndt’s Rojaus Darelis (The Garden of Paradise) that were first published in Königsberg in 1807. The goal is to show the revision trends and content transformations Arndt’s texts underwent in the second, 1816 Königsberg edition of Rojaus Darǯelis, the 1816 Tilsit edition, and the unofficial 1817 conventiclers’ (Lith. surinkimininkai) hymnal Wiſſokies Naujes Gieſmes arba Ewangelißki Pſalmai (Tilsit). The analysis of the prayers has shown that the language of the hymnal Rojaus Darelis (Königsberg, 1807) is rather grounded on the standard of the official ecclesiastical and philological papers of Prussian Lithuania: the prevalent southern subdialect of the Western Aukštaitians of Prussian Lithuania. It is dominated by rather stable normative elements of morphology and diacritic orthography, as evidenced in the philological written works of the period: the grammars of the Lithuanian language by Gottfried Ostermeyer (1791) and Christian Gottlieb Mielcke (1800). The only identifiable non-grammatical orthography trait is the ending -ęs that sometimes appears in the acc. sg. endings of feminine adjectives, pronouns, and numerals. A comparison of the prayers from Rojaus Darǯelis that were published in Königsberg in 1807 and in 1816 has revealed that the texts had remained stable and free from major or significant revisions content-wise. This edition is even more consistent in its placement of the stress-marks than the one before. Efforts are made to keep up with the standard trend of spelling and language that prevailed in the official printed texts (grammars) of Prussian Lithuanian. It has been established that the making of the new edition of Rojaus Darelis published by the printing house of Johann Heinrich Post in Tilsit in 1816 relied on the Königsberg edition that had been released earlier that year. This is evidence in the morphological and lexical revisions that had been carried over. Structurally, the prayers in the 1816 Tilsit edition had remained intact. There were a little bit more orthography and syntactic differences compared to the 1816 Königsberg edition. It is probable that the Tilsit edition had had an effect on the preparation of Arndt’s prayers that were later featured in Wiſſokies Naujes Gieſmes arba Ewangelißki Pſalmai, a hymnal by Kristijonas Endrikis Mertikaitis (Tilsit, 1817). Nonetheless, it is the 1816 Königsberg edition (or the prior 1807 edition) that is to be considered the original source of the prayers published in Mertikaitis’s hymnal. It was in Wiſſokies Naujes Gieſmes arba Ewangelißki Pſalmai by Kristijonas Endrikis Mertikaitis (Tilsit, 1817) that Arndt’s prayers underwent the greatest extent of transformation. Contrary to the Königsberg or Tilsit editions mentioned in this article, this edition is teeming with differences on all sorts of levels: orthography, phonetics, morphology, lexis, word formation, and syntax. Analysis of the relationship between the sources shows that Mertikaitis’s hymnal did not try to follow the widely recognised grammatical usage. This unconventional approach most probably was the product of Mertikaitis’s savvy of the period language and lack of literacy. It is worth mentioning that Mertikaitis was not a man of academic or spiritual elite, but rather a vibrant preacher of the home-prayer service and schoolteacher who tended to pastoral care, matters of saving his own soul and those of the others as well as eternal life, someone who did not see making language more grammatically correct and standard-compliant as an important part of his earthly concern.
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Reeves, Timothy Scott. "Seeing the Salzburgers in their Books." Theological Librarianship 11, no. 1 (April 5, 2018): 1–11. http://dx.doi.org/10.31046/tl.v11i1.474.
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The “Salzburger Collection” that once belonged to the group of pietist Lutherans who emigrated from Salzburg, Austria to Ebenezer, Georgia in 1734 and is now preserved at the Crumley Archives in Columbia, SC, contains 160 books printed 1615-1824. After a brief history and record of provenance of the collection, this essay focuses on books that demonstrate the connection to the pietist center of Halle (Germany) and devotion to the pietist forerunner Johann Arndt, as well as a prayer book believed to contain the “London Liturgy” passed on to the emigrant community by the Lutheran chaplain of their English patron, King George II. The collection was evaluated in light of reports and letters from earliest members of the community and their supporters as well as inscriptions and other unique identifiers, giving preferences to those volumes in the collection most closely tied to earliest members of the community. In so doing, it becomes clear that while sweeping assumption about a community based upon the presence of a book in such a collection are ill-advised, when proper attention is given to matters of provenance, the contents of a library do reflect the values of a community.
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Kolářová, Lucie. "The Book of Nature as an Open Epistemological Question in the Early Modern Period: On Theological Concepts in the Works of Johann Arndt (1555-1621) and Samuel Fabricius (1577-1625)." Studia theologica 19, no. 3 (November 8, 2017): 3–23. http://dx.doi.org/10.5507/sth.2017.050.
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Reve, Torger, Arne Kinserdal, and Ansgar Pedersen. "In memory of Johan Arndt." Scandinavian Journal of Management Studies 2, no. 3-4 (May 1986): 163–64. http://dx.doi.org/10.1016/0281-7527(86)90013-7.
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Schütz, Jenerton Arlan, and Odair Neitzel. "PENSAMENTO COMO SUSPENSÃO DO MUNDO: aproximações entre Arendt e Herbart para (re)pensar a ação pedagógica." Revista Teias 21, no. 60 (February 27, 2020): 296–309. http://dx.doi.org/10.12957/teias.2020.48663.
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À luz do pensamento de Hannah Arendt e Johann Herbart, o texto propõe refletir sobre a relação entre o pensar e o mundo comum. Afinal, o que nos faz pensar? Para dar conta de responder tal indagação, iniciaremos a discussão em torno da relação entre entendimento (Verstand) e razão (Vernunft) que Hannah Arendt faz com base em Kant; por conseguinte, faremos uma releitura da concepção de disciplina formativa ou aconselhamento de Herbart, isso, com o intuito de aferir que sujeito é levado a pensar a partir do momento em que toma a si e o mundo em reflexão (suspendendo-o); por fim, apresentamos as três figuras socráticas, que, para Arendt, fomentam a suspensão do mundo e colocam o sujeito em movimento reflexivo, sob a atividade do pensamento. Ademais, esse movimento permite (re)pensar a ação pedagógica fundada na atividade do pensamento e na continuidade, durabilidade e aperfeiçoamento do mundo humano comum, é isso que só a educação e o professor podem e devem fazer.
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Park, Jeung Keun. "Johann Arndts Paradiesgärtlein (1612) : Eine Untersuchung zu Entstehung, Quellen, Rezeption und Wirkung." 韓國敎會史學會誌 49 (April 30, 2018): 161–98. http://dx.doi.org/10.22254/kchs.2018.49.05.
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Illman, Karl-Johan, Anna Svenson, Marianne Michelson, Antoon Geels, Bent Blüdnikow, and Gabriella Dahm. "Book reviews." Nordisk Judaistik/Scandinavian Jewish Studies 19, no. 1-2 (September 1, 1998): 141–59. http://dx.doi.org/10.30752/nj.69554.
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Hannah Arendt and the Jewish question (Richard J. Bernstein, 1996) is reviewed by Karl-Johan Illman.Det judiska Stockholm (eds. David Glück, Aron Neuman & Jacqueline Stare, 1998) is reviewed by Anna Svenson.Isaac Bashevis Singer: a life (Janet Hadda, 1997) is reviewed by Marianne Michelson.Fight against idols. Erich Fromm on religion, Judaism and the bible (Svante Lundgren, 1998) is reviewed by Antoon Geels.Så vælg da livet (Bent Melchior, 1997) is reviewed by Bent Blüdnikow.Dynamisk dialog. En analytisk och konstruktiv studie av den religiösa kommunikationens problem på grundval av Martin Bubers dialogfilosofi (Christina Runquist, 1998) is reviewed by Karl-Johan Illman.Jødendommen – en udfordring (Karin Weinholt, 1997) is reviewed by Gabriella Dahm.
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Bergerhausen, Hans-Wolfgang. "Johannes Arndt, Das niederrheinisch-westfälische Reichsgrafenkollegium und seine Mitglieder (1653-1806)." Geschichte in Köln 35, no. 1 (December 1994): 131–34. http://dx.doi.org/10.7788/gik.1994.35.1.131.
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Battenberg, J. Friedrich. "Johannes Arndt, Das Niederrheinisch-Westfälische Reichsgrafenkollegium und seine Mitglieder 1653–180." Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Germanistische Abteilung 109, no. 1 (August 1, 1992): 448–50. http://dx.doi.org/10.7767/zrgga.1992.109.1.448.
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Christ, Günter. "JOHANNES ARNDT: Das Niederrheinisch-Westfälische Reichs-grafenkollegium und seine Mitglieder (1653–1806)." Annalen des Historischen Vereins für den Niederrhein 195, jg (December 1992): 274–79. http://dx.doi.org/10.7788/annalen-1992-jg42.
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Maze, Jacob. "Towards an Analytic of Violence: Foucault, Arendt & Power." Foucault Studies, no. 25 (October 22, 2018): 120. http://dx.doi.org/10.22439/fs.v25i2.5577.
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Violence is an often used but much less theoretically discussed word, even among Foucauldian scholars, with Johanna Oksala being a notable exception. However, she limits her definition of violence to physical forms. In this article, I seek to overcome the quandaries she poses for wide-ranging definitions of violence by incorporating Arendt’s critique of violence into a Foucauldian paradigm. While some work, though not a great deal, has been done on comparing Arendt and Foucault, I highlight some points of commonality that makes Arendtian violence accessible to Foucauldian scholars that mostly rest on the concept of freedom. If power is productive to the extent that it provides the potential to act otherwise, Arendt, in many ways, situates violence as the prevention of this, similar to Foucault’s account of domination. Violence and power are therefore cast in a symbiotic relationship, not limited to physicality, whereby power produces meaning as well as the ability to act and violence is projected as preventive; in such a scenario, the push for freedom can be positioned as a second-order normative claim.
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GREHAN, HELENA. "Aalst: Acts of Evil, Ambivalence and Responsibility." Theatre Research International 35, no. 1 (January 27, 2010): 4–16. http://dx.doi.org/10.1017/s0307883309990332.
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Based largely on transcripts and documentary footage of the trial, the play Aalst recounts the brutal killing of two children by their parents in the Belgian town of Aalst in 1999. This article explores the ways in which this performance engages spectators as witnesses in a play of seduction and estrangement during which the concepts of ethical responsibility and judgment are destabilized and radically challenged. Drawing on the work of Hannah Arendt, Zygmunt Bauman, Arne Johan Vetlesen and Emmanuel Levinas a case is made for the importance of ambivalence as a productive mode of reading and responding to Aalst.
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Brecht, Martin. "Wolfgang Sommer, Gottesfurcht und Fürstenherrschaft. Studien zum Obrigkeitsverständnis Johann Arndts und lutherischer Hofprediger zur Zeit der altprotestantischen Orthodoxie." Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Kanonistische Abteilung 75, no. 1 (August 1, 1989): 465–67. http://dx.doi.org/10.7767/zrgka.1989.75.1.465.
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Strom, Jonathan, and Hans-Peter Neumann. "Natura sagax: Die geistige Natur: Zum Zusammenhang von Naturphilosophie und Mystik in der frühen Neuzeit am Beispiel Johann Arndts." Sixteenth Century Journal 37, no. 4 (December 1, 2006): 1169. http://dx.doi.org/10.2307/20478191.
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Park, Jeung Keun. "Geist im Glauben, Frömmigkeit durch Glauben : Das Verständnis des Glaubens im dritten Buch von Johann Arndts “Vier Bücher vom Wahren Christentum”." Mission and Theology 46 (October 31, 2018): 209–40. http://dx.doi.org/10.17778/mat.2018.10.46.209.
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Buschmann, Arno. "Johannes Arndt, Das Heilige Römische Reich und die Niederlande 1566 bis 1648. Politisch-konfessionelle Verflechtung und Publizistik im Achtzigjährigen Krieg." Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Germanistische Abteilung 123, no. 1 (August 1, 2006): 534–37. http://dx.doi.org/10.7767/zrgga.2006.123.1.534.
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Schweitzer, Christoph E. "WOLFGANG SOMMER: Gottesfurcht und Fürstenherrschaft. Studien zum Obrigkeitsverständnis Johann Arndts und lutherischer Hofprediger zur Zeit der altprotestantischen Orthodoxie. - Göttingen: Vandenhoeck & Ruprecht 1988. (= Forschungen zur Kirchen- und Dogmengeschichte. Band 41.) 351 S. Kart. DM 78,-." Daphnis 19, no. 3 (March 30, 1990): 561–63. http://dx.doi.org/10.1163/18796583-90000506.
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Wollgast, Siegfried. "HERMANN GEYER: Verborgene Weisheit. Johann Arndts “Vier Bücher vom Wahren Christentum” als Programm einer spiritualistisch–hermetischen Theologie. I. Theologia sincerior – Johann Arndts Konzept einer mystisch–spiritualistischen Theologie. II. Libri dei – die metaphorische Programmatik der “Vier Bücher vom Wahren Christentum”. III. lumen gratiae et naturae conjungere – Spiritualistisch–hermetische Theologie. Das theosophische Programm der “Vier Bücher”. – Berlin New York: Walter de Gruyter 2001 (= Arbeiten zur Kirchengeschichte. Bd. 80. I-III.) XXII, 451 S.; VI, 370 S.; IX, 545 S., 25 Abb." Daphnis 33, no. 1-2 (May 1, 2004): 325–37. http://dx.doi.org/10.1163/18796583-90000917.
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Wilson, P. H. "Book Reviews : Das Niederrheinisch-Westfalische Reichsgrafenkollegium und seine Mitglieder (1653-1806). By Johannes Arndt. 'Veroffentlichungen des Instituts fur Euro paische Geschichte Mainz', Band 133). Mainz: Philipp von Zabern. 1991. xii + 430 pp. DM98." German History 11, no. 1 (February 1, 1993): 101–3. http://dx.doi.org/10.1177/026635549301100116.
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Klemm, P., A. Kleyer, K. Tascilar, L. Schuster, T. Meinderink, F. Steiger, U. Lange, et al. "POS1492-HPR EVALUATION OF A VIRTUAL REALITY-BASED APPLICATION TO EDUCATE HEALTHCARE PROFESSIONALS AND MEDICAL STUDENTS ABOUT INFLAMMATORY ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1030.1–1031. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1452.
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Background:Inflammatory arthritides (IA), such as rheumatoid arthritis or psoriatic arthritis, are disorders that can be difficult to comprehend for health professionals and students in terms of the heterogeneity of clinical symptoms and pathologies. New didactic approaches using innovative technologies such as Virtual Reality (VR) applications could be helpful to demonstrate disease manifestations as well as joint pathologies in a more comprehensive way. However, the potential of using a VR education concept in IA has not yet been evaluated.Objectives:We evaluated the feasibility of a VR application to educate healthcare professionals and medical students about IA.Methods:We developed a VR application using IA patients data as well as two- and three-dimensional visualized pathological joints from X-ray and computed tomography generated images (1). This VR application (called Rheumality) allows the user to interact with representative arthritic joint and bone pathologies of IA patients (Figure 1 A, B). In a consensus meeting an online questionnaire was designed to collect basic demographic data (age, sex), profession of the participants, and their feedback on the general impression, knowledge gain and potential areas of application of the VR application. The VR application was subsequently tested and evaluated by healthcare professionals (physicians, researchers, and other healthcare professionals) and medical students at predefined events (two annual rheumatology conferences and academic teaching seminars at two sites in Germany).Results:125 individuals participated in this study (56% female, 43% male, 1% non-binary). 59% of the participants were between 18-30 years of age, 18% between 31-40, 10% between 41-50, 8% between 51-60 and 5% were between 61-70. Of the participants, 50 were physicians, five researchers and four other health care professionals, the remaining were medical students (66). The participants rated the application as excellent (Figure 1 C, D), the mean rating of the VR application was 9.0/10 (SD 1.2) and many participants would recommend the use of the application, with a mean recommendation score of 3.2/4 (SD 1.1). A large majority stated that the presentation of pathological bone formation improves the understanding of the disease (120 out of 125 (96%)).Conclusion:The data show that IA-targeting innovative teaching approaches based on VR technology are feasible. The use of VR applications enables a disease-specific knowledge visualization and may add a new educational pillar to conventional educational approaches.References:[1]Kleyer A et al. Z Rheumatol 78, 112–115 (2019)Figure 1.Illustration of the VR application and evaluation resultsTwo- and three-dimensional visualized pathological joints from X-ray and computed tomography generated images in a patient with long-standing (inadequately treated) RA (A) and a patient with early RA (B). Overall rating (range 0-10) on the VR application divided into four different professional subgroups (C); recommendations of VR application in the four different professional subgroups (D). HC, health care professionals; Boxplot explanation: Crossbars represent medians, whiskers represent 5-95 percentiles (points below the whiskers are drawn as individual points), box always extends from the 25th to 75th percentiles (hinges of the plot).Disclosure of Interests:Philipp Klemm Consultant of: Lilly Deutschland GmbH, Arnd Kleyer Speakers bureau: Lilly Deutschland GmbH, Consultant of: Lilly Deutschland GmbH, Grant/research support from: Lilly Deutschland GmbH, Koray Tascilar: None declared, Louis Schuster: None declared, Timo Meinderink: None declared, Florian Steiger: None declared, Uwe Lange: None declared, Ulf Müller-Ladner: None declared, Johannes Knitza Speakers bureau: Lilly Deutschland GmbH, Philipp Sewerin Speakers bureau: Lilly Deutschland GmbH, Paid instructor for: Lilly Deutschland GmbH, Johanna Mucke Consultant of: Lilly Deutschland GmbH, Alexander Pfeil Speakers bureau: Lilly Deutschland GmbH, Paid instructor for: Lilly Deutschland GmbH, Consultant of: Lilly Deutschland GmbH, Georg Schett: None declared, Fabian Hartmann Consultant of: Lilly Deutschland GmbH, Axel Hueber Consultant of: Lilly Deutschland GmbH, Grant/research support from: Lilly Deutschland GmbH, David Simon Speakers bureau: Lilly Deutschland GmbH, Paid instructor for: Lilly Deutschland GmbH, Consultant of: Lilly Deutschland GmbH, Grant/research support from: Lilly Deutschland GmbH
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Khillan, Ratesh, Nyein Htway Yu, Haoxu Ouyang, and Mohan Preet. "Association between the Level of Serum Vitamin B12 and Venous Thromboembolism in African American Population." Blood 134, Supplement_1 (November 13, 2019): 4957. http://dx.doi.org/10.1182/blood-2019-132206.
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Background Multiple risk factors have been linked to venous thromboembolism (VTE). It is well established that elevated level of homocysteine correlated with increased risk of VTE. Some studies showed that vitamin B12 deficiency may be the cause for homocysteinemia. Therefore, it is recommended by some groups that vitamin B12 should be supplemented in the patient with high homocysteine to prevent VTE. However, more recent study has shown that there is correlation between the high serum Vitamin B12 level and risk of VTE in cancer patients.[1] provoked VTE after orthopedic surgery was also shown to be associated with elevated vitamin B12 serum levels in elderly patients. The role of vitamin B12 in VTE patients is not fully understood. Our study is to see whether there is correlation between serum Vitamin B12 level and risk of VTE in general population. Methods 177 Patients admitted to Kingsbrook Jewish Medical Center between January 1st, 2015 to December 31st, 2018 with the diagnosis of VTE were identified. 95 cases had measured serum Vitamin B12 results within 3 months. 97 patients without any history of VTE who were seen in the hematology clinic during the same period time were used as control in this study. Demographic information and Vitamin B12 level were collected. T test and chi-square were used for statistical analysis. Results VTE patients had a median age of 70, which is significantly higher than the median age of 57 in the control group. The mean level of vitamin B12 in control group was 620 pg/mL, which was lower than the average vitamin B12 level (770 pg/mL, p=0.0344) in the VTE group. When we divided the patients into 3 groups based on Vitamin B12 level: Low B12 (<250 pg/mL), Moderate B12 (250-800 pg/mL) and High B12 (>800 pg/mL). We observed 41% of VTE patients have B12 level more than 800 pg/mL while only 20% of control patients have high B12 level (chi-square, p=0.006). Discussion Our study showed that vitamin B12 level is significantly elevated in patients diagnosed with VTE and more than 40% of those patients actually have vitamin b12 level more than 800 pg/mL. It is known that elevated vitamin B12 level is associated with inflammation and increased mortality.[2] An association between elevated B12 levels and cancer has been reported in several studies [3]. It is unclear elevated vitamin B12 levels predict undiagnosed cancer which is a known risk factor for VTE or vitamin B12 directly contribute hypercoagulation. Nevertheless, we should be cautious when supplementing vitamin B12 and the dosage may need to be titrated closely. More clinical studies are definitely warranted. References 1. Arendt JFH, el al. Elevated plasma vitamin B12 levels and risk of venous thromboembolism among cancer patients: A population-based cohort study. PubMed ID: 26724465 2. Grossfeld A1, et al. Symptomatic venous thromboembolism in elderly patients following major orthopedic surgery of the lower limb is associated with elevated vitamin B12 serum levels. PubMed ID:23000313 3. Johan F.H. Arendt, Henrik T. Sørensen, Laura J. Horsfall and Irene Petersen. Elevated Vitamin B12 Levels and Cancer Risk in UK Primary Care: A THIN Database Cohort Study. EPI-17-1136 Published April 2019 Disclosures No relevant conflicts of interest to declare.
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Barnes, Robin B. "Hanns-Peter Neumann. Natura sagax — Die geistige Natur: Zum Zusammenhang von Naturphilosophie und Mystik in der frühen Neuzeit am Beispiel Johann Arndts. Frühe Neuzeit 94. Tübingen: Max Niemeyer Verlag, 2004. ix + 280 pp. index. bibl. €74. ISBN: 3-484-36594-3." Renaissance Quarterly 59, no. 2 (2006): 601–3. http://dx.doi.org/10.1353/ren.2008.0244.
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Sobota, Daniel Roland. "The Law and Question. The Phenomenon of Question as a Possible Point of Departure for the Phenomenologico-Genetic Theory of Law." Acta Universitatis Lodziensis. Folia Iuridica 90 (March 28, 2020): 105–17. http://dx.doi.org/10.18778/0208-6069.90.08.
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In his original phenomenology of law Adolf Reinach distinguishes among experiences the so-called “social acts”. These include acts directed towards other persons that require that the latter acknowledge the communicated contents and assume certain attitudes. Among these acts Reinach mentions there are promises, orders, requests and questions. He argues the promise is the special act that creates the a priori grounds of law. It is to be noted that Reinach’s phenomenology of law is of static character (in the Husserlian sense of the word) and therefore it shares all its advantages and disadvantages.
In my paper I would like to draw attention to another social act, which can also be attributed to certain law-making activities, especially from the perspective of the genetic phenomenology. It is questioning. At the same time when Reinach was working on his theory of law, his Munich friend, Johannes Daubert (1877–1947), also a student of Theodor Lipps and a friend of Edmund Husserl, who together with Reinach made an “invasion of the Munichs at Göttingen”, worked on the first phenomenology of the question. Although he did not refer his research to the phenomenon of law, we can ask whether, like Reinach’s deliberations about promises and obligation, it cannot be done. That this is possible to some extent, for example, is evinced by the Hannah Arendt and Klaus Held’s phenomenology of the political world. He points out that the public world as such arises from the primordial openness of man, understood as “zoon politikon”. This openness might be interpreted as the question which is not so much a single act as it is an attitude.
The purpose of the paper is to outline how, while starting with the phenomenological reflection over various types of utterances, one can specify their certain forms and the acts constituting them as well as the attitudes which allow for a priori grounding the phenomenon of law from the perspective of static and genetic phenomenology.
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Kolberg-Liedtke, Cornelia, Johannes Schumacher, Ramona Erber, Michael Braun, Bernhard Heinrich, Oliver Hoffmann, Peter Fasching, et al. "Abstract OT2-29-01: neoMono - An adaptive randomized neoadjuvant two arm trial in patients with TNBC comparing a mono atezolizumab window followed by atezolizumab and chemotherapy with atezolizumab and chemotherapy." Cancer Research 82, no. 4_Supplement (February 15, 2022): OT2–29–01—OT2–29–01. http://dx.doi.org/10.1158/1538-7445.sabcs21-ot2-29-01.
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Abstract Background: Improvement of systemic treatment of TNBC represents an unmet medical need. Recently, targeted therapy of regulatory immune pathways has become an important option in the treatment of numerous malignancies including breast cancer. Neoadjuvant trials combining chemotherapy and checkpoint inhibitors (KEYNOTE-522 and IMPASSION031) have demonstrated a meaningful benefit regarding pathological complete remission (pCR) and event-free survival (EFS) for the addition of PD-1- and PD-L1-inhibitors to chemotherapy among patients with TNBC, respectively. In addition, initial analyzes have presented promising results regarding event-free survival. In the neoadjuvant GeparNuevo trial only a subgroup of patients with TNBC, receiving a 2-week checkpoint inhibitor monotherapy window before the start of neoadjuvant chemotherapy in combination with checkpoint inhibition, achieved a pCR benefit as compared to patients treated with neoadjuvant chemotherapy alone. Trial Design: NeoMono is a phase 2 randomized multicenter trial recruiting male and female patients with primary TNBC (defined as ER/PR < 10% and HER2 negative). Neoadjuvant treatment in Arm A and B consists of Atezolizumab 1200 mg every 3 weeks in addition to neoadjuvant chemotherapy (i.e. 12 x Carboplatin and Paclitaxel q1w followed by Epirubicin and Cyclophosphamide q3w) In Arm A this therapy is preceded by Atezolizumab 840 mg q2w (Atezolizumab mono window). Study goals are the comparison of efficacy and safety of neoadjuvant chemotherapy with Atezolizumab with and without Atezolizumab two-week window (primary endpoint: pCR) and the identification of biomarkers predicting (early) response to or resistance against Atezolizumab. The broad translational program of the neoMono trial aims at identifying these biomarkers on tumor and patient level. The neoMono statistical design adapts the idea of a proof-of-concept trial and uses Bayesian posterior and predictive probabilities for inference about the primary hypothesis. Up to four planned efficacy interim analyses provide decision points for early stopping for success or futility. The expected maximum number of patients to be recruited is 458. Citation Format: Cornelia Kolberg-Liedtke, Johannes Schumacher, Ramona Erber, Michael Braun, Bernhard Heinrich, Oliver Hoffmann, Peter Fasching, Helmut Forstbauer, Anke Kleine-Tebbe, Georg Kunz, Michael Lux, Joachim Rom, Christian Schem, Nicole Stahl, Arndt Hartmann, Sabine Kasimir-Bauer, Hans-Christian Kolberg. neoMono - An adaptive randomized neoadjuvant two arm trial in patients with TNBC comparing a mono atezolizumab window followed by atezolizumab and chemotherapy with atezolizumab and chemotherapy [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr OT2-29-01.
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Krusche, M., P. Klemm, M. Grahammer, J. Mucke, D. Vossen, A. Kleyer, P. Sewerin, and J. Knitza. "THU0625-HPR ELECTRONIC PATIENT-REPORTED OUTCOMES: A SURVEY ABOUT ACCEPTANCE, USAGE AND BARRIERS AMONG GERMAN RHEUMATOLOGISTS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 555.1–556. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3746.
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Background:The use of patient-reported outcomes (PROs) allows for patient-centered, measurable and transparent care. Electronic PROs (ePROs) have many benefits and hold great potential to improve current usage of PROs; yet, limited evidence exists regarding acceptance, usage and barriers among rheumatologists.Objectives:This study aimed to evaluate the current level of acceptance, usage, and barriers among German rheumatologists regarding the utilization of ePROs. The importance of different ePRO features for rheumatologists was investigated. Additionally, the most frequently used PROs for patients with rheumatoid arthritis (RA) were identifiedMethods:Data was collected via an online survey consisting of 18 questions. The survey was completed by members of the Working Group Young Rheumatologists of the German Society for Rheumatology (Deutsche Gesellschaft für Rheumatologie (DGRh)) at the annual 2019 DGRh conference. Only members currently working in clinical rheumatology were eligible to complete the survey.Results:A total of 119 rheumatologists completed the survey. 90% reported collecting PROs in routine practice and 25.5% already used ePROs. 44.3% were planning to switch to ePROs in the near future.The main reason for collecting PROs was for clinical decision making (66.4%), followed by research (39.5%), reimbursement (23.5%), internal quality management (21.9%) and patient satisfaction (16.8%). The most commonly cited reason for not switching to ePROs was the unawareness of suitable software solutions (figure 1).Respondents were asked to rate the features for ePROs on a scale of 0-100 (0 = unimportant, 100 = important). The most important features were automatic score calculation and display (score: 77.5), as well as the simple data transfer to medical reports (76.9) (table 1).When asked about PROs in RA, the respondents listed pain, morning stiffness and physician global assessment (PGA) as the most frequently used PROs (figure 2).Table 1.Ratings for features of ePRO on a scale of 0-100 (0 = unimportant, 100 = important))QuestionmeanSDHow important would the graphic display be to you for ePROs?63.531.19How important would the automatic score calculation and display of ePROs be to you?77.527.64How important would the simple transfer of the ePROs in medical report be to you?76.930.07How important would an automatic alarm of yourself be for you if a critical threshold is exceeded by an ePRO?51.6533.5How important would an automatic alarm of the patient be for you if a critical threshold is exceeded by an ePRO?34.5530.61Figure 1.Reasons why ePROs are currently not used (multiple answers were possible for question)Figure 2.PROs being used in clinical practice and their respective frequencyConclusion:The potential of ePROs is widely seen, and there is a great interest in ePROs. Despite this, a minority of physicians only uses ePROs, and the main reason for not implementing was cited as the unawareness of suitable software solutions.Developers, patients and rheumatologists should work closely together to help realize the full potential of ePROs and ensure a seamless integration into clinical practice.Disclosure of Interests:Martin Krusche Consultant of: Sanofi, Novartis and Medac, Speakers bureau: Roche/Chugai, Novartis, Sobi,, Philipp Klemm Consultant of: Lilly, Medac, Manuel Grahammer Shareholder of: MG is MD and shareholder of Abaton GmbH, Johanna Mucke: None declared, Diana Vossen Consultant of: Medac, Novartis, Abvie, Speakers bureau: Abvie, BMS, Arnd Kleyer Consultant of: Lilly, Gilead, Novartis,Abbvie, Speakers bureau: Novartis, Lilly, Philipp Sewerin Grant/research support from: AbbVie Deutschland GmbH & Co. KGBristol-Myers Squibb Celgene GmbHLilly Deutschland GmbHNovartis Pharma GmbH Pfizer Deutschland GmbHRheumazentrum Rhein-Ruhr, Consultant of: AMGEN GmbH AbbVie Deutschland GmbH & Co. KG Biogen GmbHBristol-Myers Squibb Celgene GmbH Chugai Pharma arketing Ltd. / Chugai Europe GmbHHexal Pharma Janssen-CilagGmbH Johnson & Johnson Deutschland GmbHLilly Deutschland GmbH / Lilly Europe / Lilly Global Novartis Pharma GmbH Pfizer Deutschland GmbH Roche Pharma Rheumazentrum Rhein-Ruhr Sanofi-Genzyme Deutschland GmbH Swedish Orphan Biovitrum GmbH UCB Pharma GmbH, Speakers bureau: AMGEN GmbH AbbVie Deutschland GmbH & Co. KG Biogen GmbHBristol-Myers Squibb Celgene GmbH Chugai Pharma arketing Ltd. / Chugai Europe GmbHHexal Pharma Janssen-CilagGmbH Johnson & Johnson Deutschland GmbHLilly Deutschland GmbH / Lilly Europe / Lilly Global Novartis Pharma GmbH Pfizer Deutschland GmbH Roche Pharma Rheumazentrum Rhein-Ruhr Sanofi-Genzyme Deutschland GmbH Swedish Orphan Biovitrum GmbH UCB Pharma GmbH, Johannes Knitza Grant/research support from: Research Grant: Novartis
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Kernder, A., H. Morf, P. Klemm, D. Vossen, M. Meyer, I. Haase, J. Mucke, et al. "POS1458-HPR DIGITAL RHEUMATOLOGY IN THE ERA OF COVID-19: RESULTS OF A NATIONAL PATIENT AND PHYSICIAN SURVEY." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1013–14. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1328.
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Background:Digital health applications (DHAs) are gaining influence and promise great potential for the monitoring and management of rheumatic and musculoskeletal diseases (RMDs).Objectives:To analyse the impact of the COVID-19 pandemic on RMD patients’ and rheumatologists’ usage, preferences, and perception of digital health applications (DHAs) in Germany.Methods:A web-based national survey was developed by the Working Group Young Rheumatology of the German Society for Rheumatology and the German League against Rheumatism. The prospective survey was distributed via social media, QR-code, and email. Descriptive statistics were calculated, and regression analyses were performed to show correlations.Results:We analysed the responses of 299 patients and 129 rheumatologists. Most patients (74%) and rheumatologists (76%) believed that DHAs are useful in the management of RMDs and felt confident in their own usage thereof (90%; 86%). 38% of patients and 71% of rheumatologists reported that their attitude had changed positively towards DHAs and that their usage had increased due to COVID-19 (29%; 48%).Usage and recommendation of DHAs for both groups are shown in Figure 1:Figure 1.Usage or recommendation of digital health applications. Patients and rheumatologists were asked to indicate the specific digital health applications (DHAs) they used or were recommended.The majority in both groups agreed on implementing virtual visits for follow-up appointments in stable disease conditions. The most reported advantages of DHAs were usage independent of time and place (76.6%; 77.5%). The main barriers were a lack of information on suitable, available DHAs (58.5%; 41.9%), poor usability (42.1% of patients) and a lack of evidence supporting the effectiveness of DHAs (23.2% of rheumatologists) (Table 1).Table 1.Advantages and Barriers of DHA, n (%).AdvantagesBarriersPatientsRheumatologistsPatientsRheumatologistsLocation-Independence229 (76.6)100 (77.5)Too little information175 (58.5)54 (41.9)Time-independence223 (74.6)94 (72.9)Too little evidence of benefits36 (12.0)30 (23.3)Detailed documentation97 (32.4)47 (36.4)Poor quality of current apps47 (15.7)29 (22.5)Cost saving95 (31.8)37 (28.7)Concernsabout data protection52 (17.4)25 (19.4)More information88 (29.4)38 (29.5)Lack of usability126 (42.1)17 (13.2)Independenceof doctors+36 (12.0)-Lack of accessibility4 (1.3)-More flexibility107 (36.8)77 (59.7)High costs4 (1.3)23 (17.8)Preparationfor discussion+46 (15.4)-No suitable equipment17 (5.7)11 (8.5)No advantages at all18 (6.0)1 (0.8)Lack of user competenceNo Need9 (3.0)39 (13.0)-12 (9.3)Patients and rheumatologists were asked about the advantages and barriers of DHAs. Multiple answers were allowed. Patients had two additional potential advantages and potential barriers to choose from*.Only a minority (<10% in both groups) believed that digitalisation has a negative impact on the patient-doctor relationship.Conclusion:The COVID-19 pandemic instigated an increase in patients’ and rheumatologists’ acceptance and usage of DHAs, possibly introducing a permanent paradigm shift in the management of RMDs.Acknowledgements:The authors thank the following persons and societies for their great effort, distributing the online survey: P.Aries, A.Hueber, E.Feist, C.Fiehn, P.Korsten, I.Kötter, F.Mühlensiepen, A.Pfeil, M.Rudwaleit, M.Welcker, S.Zinke, Deutsche Vereinigung Morbus Bechterew e.V., Deutsche Rheuma-Liga Bundesverband e. V., Sklerodermie Selbsthilfe e.V.Disclosure of Interests:Anna Kernder: None declared, Harriet Morf: None declared, Philipp Klemm: None declared, Diana Vossen Speakers bureau: Novartis, Abbvie, Amgen, Consultant of: Abbvie Deutschland GmbH & Co. KG, Bristol-Myer Squibb, Celgene GmbH, Gilead Sciences Inc., Lilly Deutschland GmbH, Medac GmbH, Novartis Pharma GmbH, Pfizer Deutschland GmbH, UCB Pharma GmbH, Grant/research support from: Pfizer, Abbvie, Marco Meyer Consultant of: Medac, Isabell Haase Speakers bureau: Medac, Consultant of: Medac, Grant/research support from: UCB, Abbvie, BMS, Johanna Mucke Speakers bureau: AbbVie Deutschland GmbH & Co. KG, Amgen, Bristol-Myers Squibb, Chugai Pharma Germany GmbH, Celgene GmbH, Gilead Sciences Inc., GlaxoSmithKline, Janssen-Cilag GmbH, Lilly Deutschland GmbH, Novartis Pharma GmbH, Pfizer Deutschland GmbH and UCB Pharma GmbH., Consultant of: AbbVie Deutschland GmbH & Co. KG, Amgen, Bristol-Myers Squibb, Chugai Pharma Germany GmbH, Celgene GmbH, Gilead Sciences Inc., GlaxoSmithKline, Janssen-Cilag GmbH, Lilly Deutschland GmbH, Novartis Pharma GmbH, Pfizer Deutschland GmbH and UCB Pharma GmbH., Arnd Kleyer Shareholder of: yes, Speakers bureau: Lilly, Novartis, Consultant of: Abbvie, Lilly, Novartis BMS, Gilead,Janssen, Grant/research support from: Lilly, Novartis, Gilead,, Philipp Sewerin Consultant of: AbbVie, Amgen, Axiom Health, Biogen, Bristol-Myers Squibb, Celgene, Chugai Pharma Marketing Ltd./Chugai Europe, Deutscher Psoriasis-Bund, Fresenius Kabi, Gilead Sciences, Hexal Pharma, Janssen-Cilag, Johnson & Johnson, Lilly, Medi-login, Mediri GmbH, Novartis Pharma, Onkowissen GmbH, Pfizer, Roche Pharma, Rheumazentrum Rhein-Ruhr, Sanofi-Genzyme, Swedish Orphan Biovitrum, and UCB, Grant/research support from: AbbVie, Amgen, Biogen, Bristol-Myers Squibb, Bundesministerium fuer Bildung und Forschung (BMBF), Deutsche Forschungsgesellschaft (DFG), Deutscher Psoriasis-Bund, Fresenius Kabi, Gilead Sciences, Hexal Pharma, Janssen-Cilag, Lilly, Novartis Pharma, Pfizer, Rheumazentrum Rhein-Ruhr, Roche Pharma, Sanofi-Genzyme, and UCB, Gerlinde Bendzuck: None declared, Sabine Eis: None declared, Johannes Knitza Consultant of: Abbvie, Novartis, Lilly, Medac, BMS, Sanofi, Amgen, Gilead, UCB, ABATON, GSK, Grant/research support from: Novartis, UCB, Thermofisher, Sanofi, Martin Krusche Speakers bureau: Lilly, Medac, Novartis, Roche/Chugai, Consultant of: Abbvie, Lilly, Gilead, Medac, Novartis, Sobi, BMS, Amgen, GSK, Grant/research support from: Sanofi
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MacHardy, Karin J. "Das Fränkische Reichsgrafenkollegium im 16. und 17. Jahrhundert: Untersuchungen zu den Möglichkeiten und Grenzen der korporativen Politik mindermächtiger Reichsstände. Ernst Böhme , Karl Otmar Freiherr von Aretin, Peter Moraw , Volker Press, Herman WeberDas Niederheinisch-Westfälische Reichsgrafenkollegium und Seine Mitglieder (1653-1806). Johannes Arndt , Karl Otmar Freiherr von Aretin, Peter Moraw , Volker Press, Hermann Weber." Journal of Modern History 66, no. 3 (September 1994): 643–46. http://dx.doi.org/10.1086/244923.
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Knevel, R., J. Knitza, A. Hensvold, A. Circiumaru, T. Bruce, S. Evans, T. Maarseveen, et al. "OP0147 RHEUMATIC? - A DIGITAL DIAGNOSTIC DECISION SUPPORT TOOL FOR INDIVIDUALS SUSPECTING RHEUMATIC DISEASES: A MULTICENTER VALIDATION STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 87.1–88. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1118.
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Background:Digital diagnostic decision support tools promise to accelerate diagnosis and increase health care efficiency in rheumatology. Rheumatic? is an online tool developed by specialists in rheumatology and general medicine together with patients and patient organizations for individuals suspecting a rheumatic disease.1,2 The tool can be used by people suspicious for rheumatic diseases resulting in individual advise on eventually seeking further health care.Objectives:We tested Rheumatic? for its ability to differentiate symptoms from immune-mediated diseases from other rheumatic and musculoskeletal complaints and disorders in patients visiting rheumatology clinics.Methods:The performance of Rheumatic? was tested using data from 175 patients from three university rheumatology centers covering two different settings:A.Risk-RA phase setting. Here, we tested whether Rheumatic? could predict the development of arthritis in 50 at risk-individuals with musculoskeletal complaints and anti-citrullinated protein antibody positivity from the KI (Karolinska Institutet)B.Early arthritis setting. Here, we tested whether Rheumatic? could predict the development of an immune-mediated rheumatic disease in i) EUMC (Erlangen) n=52 patients and ii) LUMC (Leiden) n=73 patients.In each setting, we examined the discriminative power of the total score with the Wilcoxon rank test and the area-under-the-receiver-operating-characteristic curve (AUC-ROC).Results:In setting A, the total test score clearly differentiated between individuals developing arthritis or not, median 245 versus 163, P < 0.0001, AUC-ROC = 75.3 (Figure 1). Also within patients with arthritis the Rheumatic? total score was significantly higher in patients developing an immune-mediated arthritic disease versus those who did not: median score EUMC 191 versus 107, P < 0.0001, AUC-ROC = 79.0, and LUMC 262 versus 212, P < 0.0001, AUC-ROC = 53.6.Figure 1.(Area under) the receiver operating curve for the total Rheumatic? scoreConclusion:Rheumatic? is a web-based patient-centered multilingual diagnostic tool capable of differentiating immune-mediated rheumatic conditions from other musculoskeletal problems. A following subject of research is how the tool performs in a population-wide setting.References:[1]Knitza J. et al. Mobile Health in Rheumatology: A Patient Survey Study Exploring Usage, Preferences, Barriers and eHealth Literacy. JMIR mHealth and uHealth. 2020.[2]https://rheumatic.elsa.science/en/Acknowledgements:This project has received funding from EIT Health. EIT Health is supported by the European Institute of Innovation and Technology (EIT), a body of the European Union that receives support from the European Union’s Horizon 2020 Research and Innovation program.This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777357, RTCure.Disclosure of Interests:Rachel Knevel: None declared, Johannes Knitza: None declared, Aase Hensvold: None declared, Alexandra Circiumaru: None declared, Tor Bruce Employee of: Ocean Observations, Sebastian Evans Employee of: Elsa Science, Tjardo Maarseveen: None declared, Marc Maurits: None declared, Liesbeth Beaart- van de Voorde: None declared, David Simon: None declared, Arnd Kleyer: None declared, Martina Johannesson: None declared, Georg Schett: None declared, Thomas Huizinga: None declared, Sofia Svanteson Employee of: Elsa Science, Alexandra Lindfors Employee of: Ocean Observations, Lars Klareskog: None declared, Anca Catrina: None declared
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Kerres, Michael, and Claudia De Witt. "Editorial: Medien in der Erziehungswissenschaft." Medien in der Erziehungswissenschaft 7, Medien in der Erz.-wissenschaft (January 1, 2003): 1. http://dx.doi.org/10.21240/mpaed/07/2003.00.00.x.
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Neue Medien finden in allen Bildungskontexten zunehmend Verwendung. Vor allem durch verschiedene staatliche Förderprogramme hat der Einsatz digitaler Medien in der Hochschullehre in der letzten Zeit deutlich zugenommen. Dabei sind ganze unterschiedliche Themen aufgegriffen und didaktisch aufbereitet worden. Und Erziehungswissenschaftler/innen sind an vielen Medienprojekten beteiligt, wenn es um die didaktische Konzeption und die Evaluation der Projekte geht. Das Medienthema gewinnt in der Erziehungswissenschaft insgesamt an Bedeutung, wie man an Kongressen und der deutlich zunehmenden Anzahl an Publikationen erkennen kann. Im Unterschied zu der zunehmenden Reflexion der Medienthematik spielt der Medieneinsatz in der erziehungswissenschaftlichen Lehre allerdings eine relativ geringe Rolle. Die Nutzung digitaler Medien zur Vermittlung erziehungswissenschaftlicher Inhalte bzw. in der Auseinandersetzung mit erziehungswissenschaftlichen Inhalten bleibt insgesamt marginal. Hinzu kommt, dass nicht zuletzt aufgrund der Zersplitterung der Erziehungswissenschaft in diverse Teildisziplinen entsprechende Medienaktivitäten von Erziehungswissenschaftler/innen wenig Binnen-Vernetzung aufweisen, ja vielfach in der eigenen Disziplin wenig bekannt sind bzw. wenig Austausch zwischen fachlich benachbarten Aktivitäten stattfindet. In dieser Ausgabe soll der Fokus deswegen auf Medienprojekte mit erziehungswissenschaftlichen Lerninhalten gelegt werden: Welche Medien gibt es zu erziehungswissenschaftlichen Themen (in ihrer gesamten Bandbreite)? Wie sieht der Medieneinsatz in erziehungswissenschaftlichen Kontexten, der Lehreraus- und -weiterbildung, der Aus- und Weiterbildung in pädagogischen Diplom-Studiengängen aus? Dies waren Themen der 1. MEWISS-Tagung («Medien in der Erziehungswissenschaft») im Duisburg Learning Lab der Universität Duisburg-Essen, die gemeinsam mit der Sektion Medien- und Umweltpädagogik der Deutschen Gesellschaft für Erziehungswissenschaft organisiert wurde, und die in den folgenden Beiträgen diskutiert werden. So thematisiert Michael Kerres den Status und die Probleme der Mediennutzung in der erziehungswissenschaftlichen Lehre an Hochschulen. Er stellt heraus, dass die Mediennutzung in der Erziehungswissenschaft notwendigerweise intensiviert werden muss, und zeigt mögliche Aktivitäten auf. Winfried Marotzki, Arnd-Michael Nohl und Wolfgang Ortlepp stellen ein Konzept bildungstheoretisch orientierter Internetarbeit vor. Dafür formulieren sie zunächst drei Anliegen von Bildung und überführen dann dieses bildungstheoretische Modell in ein didaktisches, um es als Grundlage für ein Internetprojekt mit Studierenden der Erziehungswissenschaft einzusetzen. Das Entwicklungsprojekt «Studbene«, das Johannes Busse, Benno Volk und Christiane Schiersmann vorstellen, bildet Studierende geistes- und sozialwissenschaftlicher Fächer zu Lernberater/innen für Neue Medien aus. Damit sollen eine «praxistaugliche Medienkompetenz» und «themenzentrierte Beratungskompetenz» vermittelt werden. Ein weiterbildendes Online-Studienprogramm an einer Präsenzuniversität ist «Educational Media«, dessen Idee, Konzeption und Umsetzung Claudia de Witt vorstellt. Es handelt sich dabei um ein berufsbegleitendes Masterprogramm zur Mediendidaktik und ihren interdisziplinären Bezügen. Ricarda T. D. Reimer präsentiert ein webbasiertes Lernsetting im Design von «Blended Learning» in der Hochschule, um daran einen effizienten Einsatz technologiebasierter Lehr-/Lernprozesse zu zeigen. Susanne Schumacher dokumentiert die Erfahrungen mit einer Online-Veranstaltung zum Thema «Zur Theorie des Unterrichts» im Rahmen der Lehrerausbildung. Ihr Ziel ist es, traditionelle Hochschullehre mit einer E-Learning-Konzeption zu vergleichen und die Grenzen für den Medieneinsatz in der Erziehungswissenschaft aufzuzeigen. Wir hoffen, dass wir mit dieser Ausgabe Anregungen und Impulse für den Medieneinsatz in der erziehungswissenschaftlichen Lehre geben können.
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Simon, D., A. Kleyer, S. Bayat, J. Knitza, L. Valor, M. Schweiger, G. Schett, K. Tascilar, and A. Hueber. "AB0495 BIOMECHANICAL STRESS IN THE CONTEXT OF COMPETITIVE SPORTS TRAINING TRIGGERS ENTHESITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1275.1–1275. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1793.
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Background:Preclinical models have indicated that biomechanical stress can trigger entheseal inflammation (1). Furthermore, enthesitis is a hallmark of psoriatic arthritis (PsA) and spondyloarthritis (SpA), suggesting that mechanoinflammation is an important step in their pathogenesis (2). However, the relation between mechanical stress and enthesitis in humans is poorly investigated. Competitive badminton is a demanding stop-and-go sport that strains entheseal sites in particular and provides an opportunity to assess the impact of physical activity on the development of an instant inflammatory response in the entheses.Objectives:To evaluate the influence of mechanical stress on the development of immediate enthesitis.Methods:BEAT (Badminton Enthesitis Arthrosonography Study) is an interventional study that assessed entheses in competitive badminton players before and immediately after a 60-minute intensive training session by ultrasound. Power Doppler (PD) signal and Gray-Scale (GS) changes were evaluated at the insertions sites of both Achilles tendon, patellar tendons and lateral humeral epicondyles and quantified using a validated scoring system (3). Pre- and post-training scores were compared using linear mixed-effects models. We used interaction terms to assess possible differential effects on patellar, elbow and Achilles entheses.Results:Thirty-two badminton players (22 men, 10 women) with an average age of 31.1±13.0 years were included (Table 1). On average, they had been playing badminton for 16.2±10.1 years. 192 entheseal sites were examined twice. The respective empirical total scores for PD examination were 0.1 (0.3) before and 0.5 (0.9) after training (Figure 1). Mean total GS scores were 2.9 (2.5) and 3.1 (2.5) before and after training, respectively. The mean total PD score difference of 0.4 between pre- and post -training was significant with a p value of 0.0014, whereas the p value for the mean total GS score difference of 0.2 was 0.63. Overall, seven participants (22%) showed an increased empirical total PD score. A mixed-effects model showed a significant increase of PD scores after training, with a mean increase per site of 0.06 (95%CI 0.01 to 0.12, p=0.017).Table 1.Baseline characteristicsDemographic characteristicsN, total32Females, N (%)10 (31.3)Age, years (mean ± SD)36.1 ± 13.0Height, cm (mean value ± SD)178.6 ± 9.9Body weight, kg (mean value ± SD)74.7 ± 13.5Smoking, N (%)11 (34.4)Alcohol, N (%)24 (75.0)Concomitant DiseasesInflammatory bowel disease, N (%)0Psoriasis, N (%) 0Uveitis, N (%)0Diabetes mellitus, N (%)0Hypertension, N (%)2 (6.3)Sports historyYears Badminton (mean ± SD)16.2 ± 10.1Figure 1.Ultrasound scores before and after training Figure 1. A Spaghetti plots depicting inividual Gray-Scale and Power Doppler ultrasound scores before and after trainingConclusion:Mechanical stress leads to rapid inflammatory responses in the entheseal structures of humans. These data support the concept of mechanoinflammation in diseases associated with enthesitis. However, while such responses may be self-contained in healthy subjects, they may be prolonged and more pronounced in certain risk groups, such as patients with PsA or SpA.References:[1]Cambré I, et al. Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis. Nature Communications. 2018; 9:4613.[2]Schett G, et al. Enthesitis: from pathophysiology to treatment. Nat Rev Rheumatol. 2017; 13:731-741.[3]Balint PV, et al. Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis: an OMERACT US initiative. Annals of the Rheumatic Diseases. 2018; 77:1730.Disclosure of Interests:David Simon: None declared., Arnd Kleyer: None declared., Sara Bayat: None declared., Johannes Knitza: None declared., Larissa Valor: None declared., Marina Schweiger: None declared., Georg Schett: None declared., Koray Tascilar: None declared., Axel Hueber Grant/research support from: Novartis Research Grant.
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Bayat, S., K. Tascilar, V. Kaufmann, A. Kleyer, D. Simon, J. Knitza, F. Hartmann, S. Adam, A. Hueber, and G. Schett. "AB0330 HIGH REMISSION RATES IN RA – REAL LIFE DATA FROM BARITICINIB." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1463.2–1464. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5263.
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Background:Recent developments of targeted treatments such as targeted synthetic DMARDs (tsDMARDs) increase the chances of a sustained low disease activity (LDA) or remission state for patients suffering rheumatoid arthritis (RA). tsDMARDs such as baricitinib, an oral inhibitor of the Janus Kinases (JAK1/JAK2) was recently approved for the treatment of RA with an inadequate response to conventional (cDMARD) and biological (bDMARD) therapy. (1, 2).Objectives:Aim of this study is to analyze the effect of baricitinb on disease activity (DAS28, LDA) in patients with RA in real life, to analyze drug persistance and associate these effects with various baseline characteristics.Methods:All RA patients were seen in our outpatient clinic. If a patient was switched to a baricitinib due to medical reasons, these patients were included in our prospective, observational study which started in April 2017. Clinical scores (SJC/TJC 76/78), composite scores (DAS28), PROs (HAQ-DI; RAID; FACIT), safety parameters (not reported in this abstract) as well as laboratory biomarkers were collected at each visit every three months. Linear mixed effects models for repeated measurements were used to analyze the time course of disease activity, patient reported outcomes and laboratory results. We estimated the probabilities of continued baricitinib treatment and the probabilities of LDA and remission by DAS-28 as well as Boolean remission up to one year using survival analysis and explored their association with disease characteristics using multivariable Cox regression. All patients gave informed consent. The study is approved by the local ethics.Results:95 patients were included and 85 analyzed with available follow-up data until November 2019. Demographics are shown in table 1. Mean follow-up duration after starting baricitinib was 49.3 (28.9) weeks. 51 patients (60%) were on monotherapy. Baricitinib survival (95%CI) was 82% (73% to 91%) at one year. Cumulative number (%probability, 95%CI) of patients that attained DAS-28 LDA at least once up to one year was 67 (92%, 80% to 97%) and the number of patients attaining DAS-28 and Boolean remission were 31 (50%, 34% to 61%) and 12(20%, 9% to 30%) respectively. Median time to DAS-28 LDA was 16 weeks (Figure 1). Cox regression analyses did not show any sufficiently precise association of remission or LDA with age, gender, seropositivity, disease duration, concomitant DMARD use and number of previous bDMARDs. Increasing number of previous bDMARDs was associated with poor baricitinib survival (HR=1.5, 95%CI 1.1 to 2.2) while this association was not robust to adjustment for baseline disease activity. Favorable changes were observed in tender and swollen joint counts, pain-VAS, patient and physician disease assessment scores, RAID, FACIT and the acute phase response.Conclusion:In this prospective observational study, we observed high rates of LDA and DAS-28 remission and significant improvements in disease activity and patient reported outcome measurements over time.References:[1]Keystone EC, Taylor PC, Drescher E, Schlichting DE, Beattie SD, Berclaz PY, et al. Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexate. Annals of the rheumatic diseases. 2015 Feb;74(2):333-40.[2]Genovese MC, Kremer J, Zamani O, Ludivico C, Krogulec M, Xie L, et al. Baricitinib in Patients with Refractory Rheumatoid Arthritis. The New England journal of medicine. 2016 Mar 31;374(13):1243-52.Figure 1.Cumulative probability of low disease activity or remission under treatment with baricitinib.Disclosure of Interests:Sara Bayat Speakers bureau: Novartis, Koray Tascilar: None declared, Veronica Kaufmann: None declared, Arnd Kleyer Consultant of: Lilly, Gilead, Novartis,Abbvie, Speakers bureau: Novartis, Lilly, David Simon Grant/research support from: Else Kröner-Memorial Scholarship, Novartis, Consultant of: Novartis, Lilly, Johannes Knitza Grant/research support from: Research Grant: Novartis, Fabian Hartmann: None declared, Susanne Adam: None declared, Axel Hueber Grant/research support from: Novartis, Lilly, Pfizer, EIT Health, EU-IMI, DFG, Universität Erlangen (EFI), Consultant of: Abbvie, BMS, Celgene, Gilead, GSK, Lilly, Novartis, Speakers bureau: GSK, Lilly, Novartis, Georg Schett Speakers bureau: AbbVie, BMS, Celgene, Janssen, Eli Lilly, Novartis, Roche and UCB
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Vodencarevic, A., K. Tascilar, F. Hartmann, M. Reiser, S. Bayat, J. Knitza, L. Valor, et al. "SAT0055 PREDICTION OF FLARES FOR RHEUMATOID ARTHRITIS PATIENTS ON BIOLOGIC DMARDS USING MACHINE LEARNING AND SUBSETS OF VARIABLES AVAILABLE TO PHYSICIANS, PATIENTS AND PAYERS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 959.2–960. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1553.
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Background:Today approximately 50 percent of patients with RA reach sustained remission. In a specific subset of RA patients in stable remission, biological Disease Modifying Anti-Rheumatic Drugs (bDMARDs) may be successfully tapered. However, it remains challenging to predict the patients’ individual flare risk. As we have recently shown, machine learning based on extensive clinical and laboratory data could be used to estimate individual flare risk [1].Objectives:In this study we aimed to investigate the performance of machine learning models trained with variables that are typically (1) immediately available to a physician during patient visits (clinical and demographic variables without laboratory values and composite disease activity scores), (2) theoretically available to patients at home and (3) available to payers in large health-system databases.Methods:Longitudinal clinical data of RA patients on bDMARDs from the first interim analysis of the phase-3, multicentre, randomised, open, prospective, controlled, parallel-group RETRO study (EudraCT number 2009-015740-42) was used [2] to build a predictive model for estimating the flare probability within 3 months from the current patient visit. A flare was defined as a DAS-28 ESR score over 2.6. Four different models (log. regression, random forest, k-NN and naïve Bayes) were trained which output the flare probability at each patient visit. These probabilities were used as an input for a stacking logistic regression meta-classifier [3]. The final model performance expressed as the AUROC was assessed using nested cross-validation [4]. We applied this method to three variable subsets (physician, patient, payer, Table 1).Table 1.List of variables used in three subsets:Variable / RolePhysicianPatientPayerGender (m/f)xxxDisease duration (years)xxxMethotrexate co-use (yes/no)xxxOther DMARDs co-use (yes/no)xxxDrug ATC codexxxIV-administration (yes/no)xxxDose percentagexxxAgexxxBody mass indexxxxDose percentage changexxxSwollen joint countxTender joint countxVAS_GH (pat. global disease activity)xxHAQ (health assessment questionnaire)xxSmoking status (yes/no/ex)xxAlcohol consumption (yes/no)xxPrevious flares (yes/no)xResults:Data from 135 follow-ups of 41 patients were used. The measured AUROC of the best performing model using all RETRO variables was 0.802 (95%CI 0.717 – 0.887) [1]. When a subset based on demographic and clinical variables is used that is available to a physician immediately during a patient visit the AUROC drops about 5 percent points. When only variables theoretically available to patients at home are used, the performance drops about 10 percent points comparing to the original model. Similar observation holds for the variable subset typically available to payers (Figure 1).Conclusion:This study shows that predictive models for flares have the potential to support physicians in making decisions immediately during the patient visit, even though laboratory values and respective activity scores are not yet available. In the future, machine learning applications may allow fast and reliable decisions on flare prediction in RA patients. These data can guide decisions about DMARD tapering at in real time during the physician-patient contact and allow to reduce costs not only by selective treatment tapering but also by sparing additional laboratory examinations.References:[1] Vodencarevic A. et al. Arthritis Rheumatol. 2019; 71[2] Haschka J et al. Ann Rheum Dis 2016; 75:45-51.[3] Tang J et al. CRC Press 2015; 498-500[4] Cawley GC et al. J Mach Learn Res 2010; 11:2079-2107Disclosure of Interests:Asmir Vodencarevic Shareholder of: Siemens Healthcare GmbH. Siemens Healthcare GmbH is a medical technology company (NOT a pharmaceutical company)., Employee of: Siemens Healthcare GmbH. Siemens Healthcare GmbH is a medical technology company (NOT a pharmaceutical company)., Koray Tascilar: None declared, Fabian Hartmann: None declared, Michaela Reiser: None declared, Sara Bayat Speakers bureau: Novartis, Johannes Knitza Grant/research support from: Research Grant: Novartis, Larissa Valor: None declared, Melanie Hagen: None declared, Axel Hueber Grant/research support from: Novartis, Lilly, Pfizer, Consultant of: Abbvie, BMS, Celgene, Gilead, GSK, Lilly, Novartis, Speakers bureau: GSK, Lilly, Novartis, Arnd Kleyer Consultant of: Lilly, Gilead, Novartis,Abbvie, Speakers bureau: Novartis, Lilly, Marcus Zimmermann-Rittereiser Shareholder of: Siemens Healthcare GmbH. Siemens Healthcare GmbH is a medical technology company (NOT a pharmaceutical company)., Employee of: Siemens Healthcare GmbH. Siemens Healthcare GmbH is a medical technology company (NOT a pharmaceutical company)., Georg Schett Speakers bureau: AbbVie, BMS, Celgene, Janssen, Eli Lilly, Novartis, Roche and UCB, David Simon Grant/research support from: Else Kröner-Memorial Scholarship, Novartis, Consultant of: Novartis, Lilly
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Rech, J., A. Kleyer, M. Østergaard, M. Hagen, L. Valor, K. Tascilar, G. Krönke, et al. "POS0531 ABATACEPT DELAYS THE DEVELOPMENT OF RA– CLINICAL RESULTS AFTER 18 MONTHS FROM THE RANDOMIZED, PLACEBO-CONTROLLED ARIAA STUDY IN RA-AT RISK PATIENTS." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 526.2–527. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1693.
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BackgroundThe development of RA is described by a preclinical phase of autoimmunity, that precedes clinical disease. This autoimmune phase is characterized by the presence of anti-modified protein antibodies that recognize citrullinated proteins (ACPA). A subset of individuals with ACPA develops RA, i.e. those with imaging signs of subclinical inflammation in the joints. As T cell mediated B cell activation is a key step in developing autoimmunity and RA, interventions that target this process may be useful for preventing the onset of RA. In this context, abatacept seems being an attractive therapeutic tool as it interrupts the activation of T cells and has a favourable safety profile in the treatment of RA.ObjectivesTo test whether treatment of abatacept, as compared to placebo, delays the onset of RA in ACPA positive individuals with a high risk to develop RA.MethodsARIAA is an international, randomized double-blinded placebo-controlled multi-center study in RA-at risk individuals, being ACPA positive and showing MRI signs of inflammation. The study was composed of a 6 months treatment phase with either abatacept s.c. 125 mg weekly or placebo and a 12 months observation phase with no treatment. Primary endpoint was the improvement of MRI inflammation after 6 months, secondary endpoints were the progression to RA after 6 and 18 months. The primary analysis was done on the ITT population and missing values were classified as treatment failures.ResultsBetween November 2014 and December 2019 139 RA-at risk individuals were included into ARIAA by 14 study sites (11 in Germany, 1 in the Czech Republic and 2 in Spain). Of them, 100 patients were randomized to receive either abatacept or placebo. Two patients were excluded and 98 patients could be evaluated for efficacy and safety. The primary endpoint was met: 61% of abatacept and 31% of placebo treated individuals (p=0.0043) improved in MRI inflammation. Furthermore, only 4 patients (8.2%) in the abatacept group but 17 patients in the placebo group (34.7%) progressed to RA after 6 months (p= 0.0025). Even 1 year after cessation of treatment (18 months after inclusion) the number of patients progressing to RA was lower in the abatacept group (35%) than in the placebo group (57%; p=0.0421). With respect to safety, 12 serious adverse events (each one gastritis, cellulitis, pneumonia, tendinitis calcificans, rotator cuff syndrome, cholelithiasis, peripheral artery disease, idiopathic pain syndrome, prostate cancer, penile neoplasm; trabeculectomy, cataract surgery) were reported, with only one (pneumonia) being considered to be related to treatment.ConclusionAbatacept significantly reduces subclinical joint inflammation and delays the development of RA in at-risk individuals.Table 1.ABAPBOAllN494998Females, N (%)31 (63.3)39 (79.6)70 (71.4)Age (ys); mean (±SD)51.3 (±10.8)48.5 (±12.6)49.9 (±11.7)SJC (N); mean (±SD)000TJC (N); mean (±SD)3.06 (± 3.75)3.51 (± 4.42)3.29 (±4.08)VAS Pain (mm) mean (±SD)42.2 (± 27.1)42.8 (± 33.2)42.5 (± 30.2)VAS PG (mm) mean (±SD42.2 (±28.7)43.0 (± 33.8)42.6 (± 31.2)MRI improvement, N (%)30 (61.2)15 (30.6)45 (45.9)RA at 6 months, N (%)4 (8.2)17 (34.7)21 (21.4)RA at 18 months, N (%)17 (34.7)28 (57.1)45 (45.9)AcknowledgementsThe study was supported by BMS according to the items outlined in the IIS contract and the IMI funded project RTCure.Disclosure of InterestsJürgen Rech Consultant of: Abbvie, Biogen, BMS, Chugai, GSK, Lilly, MSD; Novartis, Roche, Sanofi, Sobi, UCB, Consultancy: Biogen, BMS, Chugai, GSK, Lilly, MSD, Novartis, Roche, Sanofi, Sobi, UCB, Grant/research support from: Sobi, Novartis, Arnd Kleyer Consultant of: BMS, Pfizer, Sanofi, Abbvie, Janssen, Medac, Novartis, Lilly Deutschland GmbH, Gilead, Amgen, Grant/research support from: Novartis, Lilly Deutschland GmbH, Mikkel Østergaard: None declared, Melanie Hagen: None declared, Larissa Valor: None declared, Koray Tascilar: None declared, Gerhard Krönke: None declared, Verena Schönau: None declared, Stefan Kleinert: None declared, Xenofon Baraliakos: None declared, Juergen Braun: None declared, Martin Fleck: None declared, Andrea Rubbert-Roth: None declared, Frank Behrens: None declared, Martin Feuchtenberger: None declared, Michael Zaenker: None declared, David M Kofler: None declared, Reinhard Voll: None declared, Cornelia Glaser: None declared, Axel Hueber: None declared, Eugen Feist: None declared, Gerd Rüdiger Burmester: None declared, Kirsten Karberg: None declared, Johannes Strunk: None declared, Juan de Dios Cañete: None declared, Ladislav Šenolt: None declared, Esperanza Naredo: None declared, Georg Schett: None declared.
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Klotsche, J., C. Sengler, F. Dressler, D. Foell, I. Foeldvari, J. P. Haas, G. Horneff, et al. "POS0336 COURSE OF UVEITIS IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS: DATA FROM THE INCEPTION COHORT OF NEWLY DIAGNOSED PATIENTS WITH JIA (ICON-JIA) STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 420.2–421. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5073.
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BackgroundUveitis is an extra-articular manifestation of Juvenile idiopathic arthritis (JIA) with a prevalence of up to 20% developing most frequently in young girls and patients positive for antinuclear antibodies (ANA). Untreated and uncontrolled uveitis may lead to vision-threatening complications and even blindness.ObjectivesThe main objectives of the analyses were to determine the visual prognosis, uveitis complications and necessity of ocular surgery during the first five years of ocular disease. The likelihood of achieving an inflammation-free phase or even a remission without medication were investigated.MethodsThe Inception Cohort of Newly diagnosed patients with JIA (ICON) was initiated in 2010 in order to prospectively follow JIA patients up to 10 years after JIA disease onset. 953 Patients were assessed at enrollment, three-monthly during the first year, and six-monthly afterwards by a standardized physician’s and patient’s case report form including clinical parameters, treatment data and several laboratory parameters such as ESR, CRP or S100A12. Patients who developed uveitis underwent a regular ophthalmological assessment. The treating ophthalmologist three-monthly completed an additional questionnaire, documenting the anterior chamber (AC) cell grade, current uveitis activity (UA) and UA during the previous three months, best corrected visual acuity (BCVA), uveitis-related complications, previous ocular surgery, current topical treatment and clinical course of uveitis and additional parameters. Inactive uveitis was defined by AC cell grade of 0, quiescence of uveitis by inactive uveitis for at least 6 months, and remission by inactive uveitis for at least 6 months without topical steroids or systemic anti-inflammatory medication (steroids or DMARDs).ResultsA total of 133 children developed uveitis in the JIA disease course, of which 97 patients were documented via the ophthalmological questionnaire for at least two years resulting in a mean follow-up of 5.8 years (SD 1.8). 76% were female, 86% ANA positive, 70% oligoarthritis, and 22% rheumatoid factor negative polyarthritis and mean age at JIA onset was 3.1 (SD 2.1) and uveitis onset at 4.4 (SD 2.2) years. The mean duration between JIA onset and uveitis onset was 15.7 (SD 15.6) months. At least one ocular complication was reported for 24% of patients at first uveitis documentation and 47% of patients had at least one ocular complication until the five year follow-up. Among those, posterior synechiae (31%) and cataract (27%) were the most frequent, followed by an increased IOP (12%) with or without glaucomatous changes. Ocular surgery was rarely necessary, and visual acuity remained quite good in the majority of patients: After five years, >90% had BCVA of <0.4 LogMAR (Logarithm of the Minimum Angle of Resolution), and 63.5% even of <0.1 LogMAR. About half of the uveitis patients were already treated with DMARDs at uveitis onset. The rate of treatment with biological DMARDs increased from 10% at first uveitis documentation up to 20% at 5-year follow-up. Three in four patients were treated with topical steroids at first assessment, whereas this proportion decreased to 43%. 80 of 97 patients (83%) achieved uveitis quiescence during the first five years of disease, with more than 50% experiencing more than one episode (mean 1.5 episodes (SD 1.0)) during this time period. The mean duration of uveitis quiescence was 23.2 (SD 15.6) months. A total of 39 (40%) patients achieved uveitis remission during follow-up. The likelihood of remission was associated with a lower JIA disease activity (cJADAS10), lower erythrocyte sedimentation rate (ESR) and a higher age at JIA disease onset.ConclusionThe rate of ocular complications is already remarkable at uveitis diagnosis, and increases during uveitis disease course despite anti-inflammatory treatment. However, the visual acuity frequently remains unaffected, and the majority of patients achieve uveitis quiescence and even 40% uveitis remission within 5 years of follow-up.AcknowledgementsThe ICON study is funded by a research grant of the Federal ministry of education and research (BMBF, FKZ 01ER0812, FKZ 01ER1504A-C)Disclosure of InterestsJens Klotsche: None declared, Claudia Sengler: None declared, Frank Dressler: None declared, Dirk Foell: None declared, Ivan Foeldvari: None declared, Johannes-Peter Haas: None declared, Gerd Horneff Speakers bureau: Pfizer, Novartis, Janssen, Chugai, Abbvie, Grant/research support from: Pfizer, Novartis, MSD, Chugai, Roche, Abbvie, Toni Hospach Consultant of: SOBI, Novartis, Tilmann Kallinich: None declared, Ina Liedmann: None declared, Kirsten Moenkemoeller: None declared, Martina Niewerth: None declared, Frank Weller-Heinemann: None declared, Daniel Windschall: None declared, Arnd Heiligenhaus: None declared, Kirsten Minden: None declared, Karoline Baquet-Walscheid: None declared
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Morales Aguilera, Paulina. "La condición humana en un contexto neoliberal: interpelaciones a la intervención social hoy." Revista Intervención 8, no. 2 (December 15, 2018): 1. http://dx.doi.org/10.53689/int.v8i2.57.
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Ciertamente, este número de la revista Intervención nos brinda una nueva oportunidad de reflexionar sobre diversos temas de interés y actualidad, como son los relativos a: trabajo interprofesional y producción de subjetividades, salud pública desde una matriz asistencial, procesos de envejecimiento y vejez desde la acción colectiva en espacios comunitarios, endeudamiento en parejas jóvenes y sus consiguientes redes de intercambio y de pago, garantía de derechos en la infancia institucionalizada, y, finalmente, abordaje de crisis socioecológicas. Todos estos, a su vez, emergen cruzados por un mismo hilo conductor: la noción de intervención, ya sea desde distintos frentes como en relación con diversos niveles.
Así, no obstante referir a casos o contextos específicos, los artículos que nos acompañan en esta edición permiten desplegar algunas reflexiones subyacentes que pueden ser comunes a todos ellos. En primer término, la complejidad y –en no pocos casos- la dureza con que emergen las realidades a las que nos remiten cada uno de los textos, nos lleva a pensar en los enormes desafíos que emergen para la intervención social en la actualidad, ya sea en términos de sus fundamentos teórico-conceptuales, de sus bases epistemológicas, de su sustrato metodológico o de sus orientaciones ético-políticas. En definitiva, lo que los lectores y lectoras tienen en sus manos es un conjunto de escritos sobre tópicos y contextos diversos, pero entrelazados por una metareflexión sobre los desafíos, posibilidades y limitaciones para la intervención social misma.
En segundo lugar, estos escritos nos remiten a una reflexión de mayor grosor sobre la condición humana misma, en este caso, en relación con contextos de vulneración de derechos, territorios devastados, limitaciones a la producción de subjetividades liberadoras, endeudamiento, medicalización de la asistencia, entre otros. Hannah Arendt planteaba que la condición humana se desplegaba en la Tierra por medio de tres actividades fundamentales: Labor, Trabajo y Acción, las cuales conforman su noción de vita activa. La primera de ellas refiere a necesidades básicas como comer, dormir, vestirse, beber, entre otras. La segunda remite a las actividades productivas por medio de la utilización de los materiales de la naturaleza. La tercera actividad –la acción- es la que con mayor nitidez permite diferenciar al ser humano del resto de la naturaleza; es en definitiva, la que permite que el ser humano desarrolle su capacidad más propia: la capacidad de ser librei.
Pero, ¿por qué recurrir al marco arendtiano como lugar desde el cual mirar estos artículos? Entre otras cosas porque, volviendo a la reflexión sobre la libertad, para Arendt esta no se reduce a la mera capacidad de elección, sino que es por sobre todo la capacidad de transcender a lo dado e iniciar algo nuevo por medio de la acción. Y en el concepto de acción están contenidos tres rasgos esenciales de lo humano: la intersubjetividad, el lenguaje y la capacidad de ser libre. De una u otra forma, los escritos recogidos en el presente número nos vuelven hacia estos elementos, ya sea para mirar sus formas de despliegue –nunca desinteresadamente- como para visualizar también sus posibilidades y limitaciones.
Cuando decimos limitaciones estamos pensando en formas de sometimiento, de conculcación de derechos, en definitiva, en todo lo que impide que los seres humanos extiendan y ensanchen su capacidad de acción. Pero también en las formas institucionalizadas de cercenamiento de libertades, incluso desde programas y proyectos de intervención estatales o público-privados. Lo que esto nos muestra es, justamente, todo lo contrario a la idea de condición humana en sentido arendtiano; es la emergencia de la condición neoliberal, que en palabras de Lazzarato se erige sobre una comprensión contemporánea de la economía que incorpora, a la vez, la producción económica y la producción de subjetividadesii.
Esa condición neoliberal es la que se trasluce, exuda o vocifera –dependiendo de la intensidad- en los artículos que aquí compartimos. Es la condición en que se encuentran muchos profesionales en la primera línea de implementación de políticas y programas sociales cuyo sustrato es un neoliberalismo con profunda vocación hegemónica. Así lo exponen Gianinna Muñoz Arce y Johanna Madrigal Calderón en su artículo «Trabajo interprofesional en Chile: neoliberalismo y la producción de subjetividades profesionales críticas», a partir de un estudio que identifica los factores críticos que dan forma, facilitan y obstaculizan el trabajo interprofesional en programas pro-integralidad. En este contexto, los profesionales se ubican frente a una encrucijada en relación con la retórica macroinstitucional, por una parte, y las condiciones de operación concretas en los programas, por otra, con las consecuentes limitaciones a la producción de subjetividades profesionales críticas.
Es también la condición de esos sujetos de la asistencia social tratados como portadores de patologías que requieren siempre ser debidamente acreditadas, tal como lo muestra Melisa Campana en su artículo «La matriz asistencial de la salud pública. Aportes desde la gubernamentalidad». En concordancia con la perspectiva foucaultiana a la base, su autora da cuenta de un trabajo genealógico que permite comprender cómo se construyó el vínculo tan estrecho entre el dispositivo sanitario y el asistencial, de forma tal que la exigencia de una certificación médica haya terminado transformándose en condición para el acceso a y la permanencia en la casi totalidad de los beneficios de planes y programas asistenciales en Argentina.
Son esos adultos mayores que cuentan con escasos espacios de acción colectiva y de decisión, dada no solo su situación de vejez sino también de pobreza. De esto da cuenta, desde Argentina, el artículo de Paula Danel, titulado «De disputas y hegemonías en las intervenciones con personas mayores en espacios comunitarios», en donde se problematizan tres aspectos específicos. Por una parte, las formas en que son pensadas las intervenciones (en lo social, político, profesional, interdisciplinar, etc.). Por otra, la noción de colectivización de las personas mayores, de larga presencia allende Los Andes. Finalmente, la idea de territorio, en tanto categoría actualmente en disputa en las ciencias sociales.
Son también esas parejas sobre endeudadas que intentan llegar a fin de mes en un mar de deudas con el sistema crediticio, tal como nos muestra el artículo de Lorena Pérez-Roa y Javier Donoso-Bravo, «Redes sociales de intercambio y de pago de deudas en parejas jóvenes profesionales endeudadas de Santiago de Chile». Aquí sus autores develan el carácter relacional de los procesos de endeudamiento y la forma en que se reconfiguran la naturaleza y las significaciones de las redes sociales para hacer frente a las deudas contraídas. Late aquí la consideración lazzaratiana sobre la emergencia del endeudamiento como una nueva forma de opresión, recreada ahora en la relación entre deudores y acreedores.
Son esos niños, niñas y adolescentes institucionalizados y vulnerados en sus derechos cotidianamente, muchas veces incluso por el desconocimiento de las prerrogativas que les corresponden. Esto es lo que muestra el artículo de Nuria Cunill-Grau, Cristian Leyton y Viviana Abarca, titulado «Una mirada multidimensional a la garantía de derechos. Los centros residenciales para niñas, niños y adolescentes». Sus autores, tras una exhaustiva investigación, relevan la utilización de una perspectiva de derechos multidimensional, a la vez que evidencian los nudos críticos en el funcionamiento de estos espacios, desde la perspectiva tanto de los adultos responsables y/o significativos como de los directores de residencias. Dimensiones como la participación, el acceso a la información y la rendición de cuentas, muestran bajos niveles de concreción, en coherencia con un enfoque de derechos como el propuesto.
La condición neoliberal es también la de una naturaleza devastada en nombre de un supuesto progreso, de la falta de planificación urbana, de la batalla ganada por grandes consorcios que lucran con viviendas y territorios. En este terreno –aunque desde una óptica acotada tanto teórica como fenoménicamente- se encuentra el artículo de Gabriela Azócar: «Vulnerabilidad y resiliencia como condiciones de intervención de crisis socio-ecológicas». A partir de las nociones que orientan el texto, reflejadas en el título, se plantea que la coordinación de esferas de conocimiento y prácticas asociadas a los impactos del cambio climático es una condición para el desarrollo de intervenciones frente a crisis socio-ecológicas. Como ejemplo de estas últimas se analiza el caso de los incendios forestales en Chile, en donde se visualiza con nitidez la doble finalidad de las intervenciones, a saber, la estabilización de las condiciones de vida de las comunidades afectadas y la reparación de los daños medioambientales provocados por dicha crisis.
Nos encontramos, así, frente a la contraposición entre la condición humana y la condición neoliberal. Porque esta última no puede recibir carta de humanidad, pues a lo más propicia formas de sobrevivencia infra o subhumanas. Con Lazzarato vemos como la privatización de los servicios sociales, la individualización de la política social y la orientación de la protección social como una función empresarial fundamentan una economía de la deuda que vuelve deudores a personas, colectivos y Estados, y desde allí ejerce su opresión.
Frente a ello, la comprensión arendtiana de lo humano releva la vinculación indisoluble entre acción y discurso que es propia de la pluralidad humana. Y son esos discursos, esas voces, muchas veces invisibilizadas, las que intentan rescatar los textos que conforman este número que aquí presentamos. Son también los lenguajes que están detrás de las propuestas de intervención a las que remiten, pues la intervención es una forma de enunciación y de acción a la vez, con miras a la concreción -o al menos aproximación- al horizonte de transformación que la dota de sentido. Esto, dado que desde una óptica u otra, desde matrices teóricas, epistemológicas y ético-políticas diversas, la intervención emerge como una forma de mirar, de nombrar y de actuar -de manera no desinteresada- frente a determinadas realidades que se han vuelto altamente complejas y problemáticas. Esta consideración permite incluso engarzar con la comprensión luhmanniana que releva el papel del lenguaje en el abordaje de las crisis sistémicas frente a las cuales se requiere intervenir, por medio de la visibilización de sus contradicciones y controversiasiii.
Les invitamos, pues, a iniciar la lectura de esta nueva edición de la revista Intervención, que espera -como siempre- brindar un espacio de reflexión y debate sobre tópicos actuales y de relevancia en el vasto campo de la intervención social. Agradecemos el excelente trabajo de edición para este número, realizado por Natalia Hernández Mary. Ciertamente, esta tarea de reflexión crítica se renueva especialmente este 2018, cuando nuestro Departamento de Trabajo Social está cumpliendo 15 años de fecunda vida. Sean todos bienvenidos y bienvenidas en este esfuerzo de pensar otros mundos posibles. Sea bienvenido el diálogo orientado al consenso, pero también los nutritivos y necesarios disensos.
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Büttgen, Philippe. "'SCHNEIDER, Hans, Der fremde Arndt. Studien zu Leben, Werk und Wirkung Johann Arndts (1555-1621)'." Revue de l’Institut français d’histoire en Allemagne, January 1, 2007. http://dx.doi.org/10.4000/ifha.535.
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Imre, Mihály. "Johann Gerhard 18. századi hazai recepciójának néhány jellemzője." Studia Litteraria 52, no. 3-4 (July 1, 2013). http://dx.doi.org/10.37415/studia/2013/52/4212.
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Die Meditationes Sacrae von Johann Gerhard hatten von 1616 bis 1804 zehn ungarische Übersetzungen. Die Übersetzer waren Boldizsár Zólyomi Perinna, Mihály Ács jun., Mátyás (Matthias) Bél, István Huszti Szabó, József Inczédy. Neben den Schriften von Johann Arndt war es das meistverbreitete Werk der pietistischen Erbauungsliteratur, ein „Bestseller der geistlichen Literatur”. Die Meditationes sacrae stehen in engem Zusammenhang mit den hervorragenden Autoren und Werken der Mystik. In der Forschung wurden vor allem die Zusammenhänge mit dem Wahren Christentum, mit Tauler und mit Bernhard von Clairvaux festgestellt, aber das Werk war auch eine wichtige Vorlage für die sich erneuernde Meditationsliteratur. Unter den deutschen Ausgaben des Werkes gibt es versifizierte Varianten mit Holzschnitten. In diesen Ausgaben wirkten Text und die Bilder der Embleme zusammen. Im Jahre 1745 erschien in Hermannstadt die Übersetzung von József Inczédy unter dem Titel Liliomok völgye (Tal der Lilien) mit zehn Holzschnitten. Diese Ausgabe kann als die reformierte Variante des genannten Werkes betrachtet werden. Die Themen der Meditationen folgten den Holzschnitten, in der Textgestaltung ist das anthropologische und sprachliche Instrumentarium der Mystik zu erkennen. Die Besonderheit der Übersetzung ist die gereimte Prosa, welche die Merkmale des Barocks aufweist. Die zehn Schnitte tauchen seit Mitte des 18. Jahrhunderts in den reformierten Kirchen Siebenbürgens als Bilder und Holzverzierungen (Kassettendecke, Kanzel, Empore, Bänke) auf. Dadurch verwandelte sich die pietistische Meditation: sie erhielt eine visuelle und didaktische Funktion in der Kirchgemeinde.
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Veit, Patrice. "'AXMACHER, Elke, Johann Arndt und Paul Gerhardt. Studien zur Theologie, Frömmigkeit und geistlichen Dichtung des 17. Jahrhunderts'." Revue de l’Institut français d’histoire en Allemagne, January 1, 2003. http://dx.doi.org/10.4000/ifha.1110.
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"In Memoriam Johan Arndt." Journal of Macromarketing 6, no. 1 (June 1986): 3. http://dx.doi.org/10.1177/027614678600600102.
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"Johan Arndt Initial Slater Award Winner." Journal of Macromarketing 6, no. 2 (December 1986): 3. http://dx.doi.org/10.1177/027614678600600204.
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Daiber, Thomas. "Die polnische Übersetzung von Johann Arndts „Wahrem Christentum“." Zeitschrift für Slawistik 49, no. 1 (January 2004). http://dx.doi.org/10.1524/slaw.2004.49.1.3.
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Dyvi, Ellen Beate. "Praksiseierne etablerer forening." Den norske tannlegeforenings Tidende 113, no. 17 (December 10, 2003). http://dx.doi.org/10.56373/2003-17-11.
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ble dannet 24. oktober i år. I foreningens interimstyre sitter frem til høsten 2004: Edgar Hundsnes, leder, Bergen Inger-Johanne Nyland, nestleder, Stavanger Arnt Einar Andersen, styremedlem, Trondheim Olaug Egeland, styremedlem, Oslo Carl-Henrik Gullaksen, styremedlem, Oslo Liz Günther, styremedlem, Oslo Gard Lauvsnes, styremedlem, Oslo Med tale- og forslagsrett: Dag R. Abrahamsen, rådgiver Genesis Communication, Oslo Nina Gullaksen, sekretær, Oslo
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Maze, Jacob. "Towards an Analytic of Violence: Foucault, Arendt & Power." Foucault Studies, October 22, 2018, 120–45. http://dx.doi.org/10.22439/fs.v0i25.5577.
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Violence is an often used but much less theoretically discussed word, even among Foucauldian scholars, with Johanna Oksala being a notable exception. However, she limits her definition of violence to physical forms. In this article, I seek to overcome the quandaries she poses for wide-ranging definitions of violence by incorporating Arendt’s critique of violence into a Foucauldian paradigm. While some work, though not a great deal, has been done on comparing Arendt and Foucault, I highlight some points of commonality that makes Arendtian violence accessible to Foucauldian scholars that mostly rest on the concept of freedom. If power is productive to the extent that it provides the potential to act otherwise, Arendt, in many ways, situates violence as the prevention of this, similar to Foucault’s account of domination. Violence and power are therefore cast in a symbiotic relationship, not limited to physicality, whereby power produces meaning as well as the ability to act and violence is projected as preventive; in such a scenario, the push for freedom can be positioned as a second-order normative claim.