Relevant bibliographies by topics / ARNi

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Academic literature on the topic 'ARNi'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 July 2024

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Journal articles on the topic "ARNi"

1

Stanko, Peter, Kristina Repova, Tomas Baka, Kristina Krajcirovicova, Silvia Aziriova, Andrej Barta, Stefan Zorad, Michaela Adamcova, and Fedor Simko. "Sacubitril/Valsartan Alleviates Cardiac Remodeling and Dysfunction in L-NAME-Induced Hypertension and Hypertensive Heart Disease." Biomedicines 12, no. 4 (March 25, 2024): 733. http://dx.doi.org/10.3390/biomedicines12040733.

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There is ample evidence on the benefit of angiotensin receptor-neprilysin inhibitors (ARNIs) in heart failure, yet data regarding the potential protective action of ARNIs in hypertensive heart disease are sparse. The aim of this study was to show whether an ARNI exerts a protective effect in a model of Nω-nitro-L-arginine methyl ester (L-NAME)-induced hypertension with a hypertensive heart and to compare this potential benefit with an angiotensin-converting enzyme inhibitor, captopril. Five groups of adult male Wistar rats were studied (14 per group) for four weeks: untreated controls; ARNI (68 mg/kg/day); L-NAME (40 mg/kg/day); L-NAME treated with ARNI; and L-NAME treated with captopril (100 mg/kg/day). L-NAME administration induced hypertension, accompanied by increased left ventricular (LV) weight and fibrotic rebuilding of the LV in terms of increased concentration and content of hydroxyproline in insoluble collagen and in total collagen and with a histological finding of fibrosis. These alterations were associated with a compromised systolic and diastolic LV function. Treatment with either an ARNI or captopril reduced systolic blood pressure (SBP), alleviated LV hypertrophy and fibrosis, and prevented the development of both systolic and diastolic LV dysfunction. Moreover, the serum levels of prolactin and prolactin receptor were reduced significantly by ARNI and slightly by captopril. In conclusion, in L-NAME-induced hypertension, the dual inhibition of neprilysin and AT1 receptors by ARNI reduced SBP and prevented the development of LV hypertrophy, fibrosis, and systolic and diastolic dysfunction. These data suggest that ARNI could provide protection against LV structural remodeling and functional disorders in hypertensive heart disease.
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Żelazny, Przemysław, Joanna Filipczak, Oliwer Sygacz, Sebastian Bróż, Sara Dankiewicz, Aleksandra Swora, Joanna Borowik, Wojciech Brodowski, Piotr Pawłowski, and Katarzyna Basta-Arciszewska. "Angiotensin Receptor Antagonist-Neprilysin Inhibitor (ARNI) therapy as a new hope in the population of people with heart failure with reduced ejection fraction (HFrEF)." Journal of Education, Health and Sport 12, no. 9 (September 8, 2022): 583–88. http://dx.doi.org/10.12775/jehs.2022.12.09.068.

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Introduction: Heart failure affects an estimated 23 million people, as many as 50% of whom suffer from a heart failure with reduced ejection fraction (HFrEF), in which the left ventricle ejection fraction is <40% and is accompanied by clinical symptoms. Given the high mortality rate in this group of patients and the continuous suboptimal control of the condition, novel pharmacotherapy regimens are needed to slow the progression of the disease. Preliminary studies report a positive effect of including an angiotensin receptor antagonist and neprilysin inhibitors (ARNIs) in this group of patients. Aim of the study: The aim of the study was to summarize the benefits of ARNI in a group of patients with HFrEF. Methods and materials: This article is based on the literature found in PubMed Database with use of keywords such as “ARNI”, “neprilysin inhibition”, HFrEF”, “heart failure” Results: The benefits of ARNI therapy in patients with HFrEF originate from reversing myocardial remodeling and increasing left ventricular ejection fraction. ARNI therapy is associated with reduced number of hospitalizations and a lower need for intensive treatment. In addition, ARNI use reduces the risk of cardiovascular death and is responsible for lower overall mortality rate compared to pharmacotherapy with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor antagonists (ARBs). Conclusion: ARNIs in patients with HFrEF have a positive effect on the rate of cardiovascular hospitalization, as well as reducing cardiovascular-related mortality and total mortality. Future research studies should evaluate the predictive factors of response to treatment with this group of drugs using larger groups of patients.
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Gamero, Maira, Deisy Toloza-Moreno, Mariano Belaich, and Gloria Patricia Barrera Cubillos. "ARN de interferencia (ARNi): una herramienta eficaz en agrobiotecnología." Revista Colombiana de Biotecnología 24, no. 2 (December 1, 2022): 59–67. http://dx.doi.org/10.15446/rev.colomb.biote.v24n2.99397.

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El ARN de interferencia (ARNi) es un mecanismo evolutivamente conservado en la mayoría de las células eucariotas que permite silenciar genes mediante la degradación de ARN mensajero (ARNm) y la supresión de la síntesis de proteínas. En plantas, las moléculas de ARNi están involucradas en mecanismos de defensa contra patógenos y transposones, en la respuesta adaptativa al estrés, y en la expresión de genes relacionados con su crecimiento. El ARNi se considera una herramienta biotecnológica eficaz para silenciar la expresión de genes de microorganismos fitopatógenos, esto permite el diseño de bioplaguicidas ambientalmente seguros con una afinidad y selectividad, en muchos casos superior a la de los plaguicidas químicos. En esta revisión se señalan los últimos avances en la aplicación del ARNi en el contexto agrícola y su efectividad en el control biológico de fitopatógenos e insectos plaga. Asimismo, se presentan diversos ensayos experimentales cuyos resultados pueden ser la base para futuros bioproductos, además de algunos ejemplos disponibles en el mercado. Por último, se abordan aspectos de bioseguridad y consideraciones regulatorias necesarias para la aceptación y uso de esta tecnología a nivel global.
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Niemiec, Rafał, Irmina Morawska, Maria Stec, Wiktoria Kuczmik, Andrzej S. Swinarew, Arkadiusz Stanula, and Katarzyna Mizia-Stec. "ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations." International Journal of Environmental Research and Public Health 19, no. 4 (February 13, 2022): 2089. http://dx.doi.org/10.3390/ijerph19042089.

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Background: Sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), has demonstrated a survival benefit and reduces heart failure hospitalization in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, our experience in this field is limited. This study aimed to summarize a real clinical practice of the use of ARNI in HFrEF patients hospitalized due to HFrEF in the era before the 2021 ESC HF recommendations, as well as assess their clinical outcome with regard to ARNI administration. Methods and Materials: Overall, 613 patients with HFrEF hospitalized in 2018–2020 were enrolled into a retrospective one-centre cross-sectional analysis. The study population was categorized into patients receiving (82/13.4%) and not-receiving (531/82.6%) ARNI. Clinical outcomes defined as rehospitalization, number of rehospitalizations, time to the first rehospitalization and death from any cause were analysed in the 1–2 year follow-up in the ARNI and non-ARNI groups, matched as to age and LVEF. Results: Clinical characteristics revealed the following differences between ARNI and non-ARNI groups: A higher percentage of cardiovascular implantable electronic devices (CIED) (p = 0.014) and defibrillators with cardiac resynchronization therapy (CRT-D) (p = 0.038), higher frequency of atrial fibrillation (p = 0.002) and history of stroke (p = 0.024) were in the ARNI group. The percentage of patients with HFrEF NYHA III/IV presented an increasing trend to be higher in the ARNI (64.1%) as compared to the non-ARNI group (51.5%, p = 0.154). Incidence of rehospitalization, number of rehospitalizations and time to the first rehospitalization were comparable between the groups. There were no differences between the numbers of deaths of any cause in the ARNI (28%) and non-ARNI (28%) groups. The independent negative predictor of death in the whole population of ARNI and non-ARNI groups was the coexistence of coronary artery disease (CAD) (beta= −0.924, HR 0.806, p = 0.011). Conclusions: Our current positive experience in ARNI therapy is limited to extremely severe patients with HFrEF. Regardless of the more advanced HF and HF comorbidities, the patients treated with ARNI presented similar mortality and rehospitalizations as the patients treated by standard therapy.
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Kim, Donghyun, Gyuho Jang, Jaetaek Hwang, Xiaofan Wei, Hyunsoo Kim, Jinbae Son, Sang-Jae Rhee, et al. "Combined Therapy of Low-Dose Angiotensin Receptor–Neprilysin Inhibitor and Sodium–Glucose Cotransporter-2 Inhibitor Prevents Doxorubicin-Induced Cardiac Dysfunction in Rodent Model with Minimal Adverse Effects." Pharmaceutics 14, no. 12 (November 28, 2022): 2629. http://dx.doi.org/10.3390/pharmaceutics14122629.

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Although cancer-therapy-related cardiac dysfunction (CTRCD) is a critical issue in clinical practice, there is a glaring lack of evidence regarding cardiotoxicity management. To determine an effective and suitable dosage of treatment using angiotensin receptor–neprilysin inhibitors (ARNI) with sodium–glucose cotransporter 2 inhibitors (SGLT2i), we adopted a clinically relevant rodent model with doxorubicin, which would mimic cardiac dysfunction in CTRCD patients. After the oral administration of drugs (vehicle, SGLT2i, ARNI, Low-ARNI/SGLT2i, ARNI/SGLT2i), several physiologic parameters, including hemodynamic change, cardiac function, and histopathology, were evaluated. Bulk RNA-sequencing was performed to obtain insights into the molecular basis of a mouse heart response to Low-ARNI/SGLT2i treatment. For the first time, we report that the addition of low-dose ARNI with SGLT2i resulted in greater benefits than ARNI, SGLT2i alone or ARNI/SGLT2i combination in survival rate, cardiac function, hemodynamic change, and kidney function against doxorubicin-induced cardiotoxicity through peroxisome proliferator-activated receptor signaling pathway. Low-dose ARNI with SGLT2i combination treatment would be practically beneficial for improving cardiac functions against doxorubicin-induced heart failure with minimal adverse effects. Our findings suggest the Low-ARNI/SGLT2i combination as a feasible novel strategy in managing CTRCD patients.
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Roksnoer, Lodi C. W., Richard van Veghel, Marian C. Clahsen van Groningen, René de Vries, Ingrid M. Garrelds, Usha M. Bhaggoe, Jeanette M. G. van Gool, et al. "Blood pressure-independent renoprotection in diabetic rats treated with AT1 receptor–neprilysin inhibition compared with AT1 receptor blockade alone." Clinical Science 130, no. 14 (June 1, 2016): 1209–20. http://dx.doi.org/10.1042/cs20160197.

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ARNI [dual AT1 (angiotensin II type 1) receptor–neprilysin inhibition] exerts beneficial effects on blood pressure and kidney function in heart failure, compared with ARB (AT1 receptor blockade) alone. We hypothesized that ARNI improves cardiac and kidney parameters in diabetic TGR(mREN2)27 rats, an angiotensin II-dependent hypertension model. Rats were made diabetic with streptozotocin for 5 or 12 weeks. In the final 3 weeks, rats were treated with vehicle, irbesartan (ARB) or irbesartan+thiorphan (ARNI). Blood pressure, measured by telemetry in the 5-week group, was lowered identically by ARB and ARNI. The heart weight/tibia length ratio in 12-week diabetic animals was lower after ARNI compared with after ARB. Proteinuria and albuminuria were observed from 8 weeks of diabetes onwards. ARNI reduced proteinuria more strongly than ARB, and a similar trend was seen for albuminuria. Kidneys of ARNI-treated animals showed less severe segmental glomerulosclerosis than those of ARB-treated animals. After 12 weeks, no differences between ARNI- and ARB-treated animals were found regarding diuresis, natriuresis, plasma endothelin-1, vascular reactivity (acetylcholine response) or kidney sodium transporters. Only ARNI-treated rats displayed endothelin type B receptor-mediated vasodilation. In conclusion, ARNI reduces proteinuria, glomerulosclerosis and heart weight in diabetic TGR(mREN2)27 rats more strongly than does ARB, and this occurs independently of blood pressure.
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Ohnewein, Bernhard, Zornitsa Shomanova, Vera Paar, Albert Topf, Peter Jirak, Lukas Fiedler, Christina Granitz, et al. "Effects of Angiotensin Receptor-Neprilysin Inhibitors (ARNIs) on the Glucose and Fat Metabolism Biomarkers Leptin and Fructosamine." Journal of Clinical Medicine 12, no. 9 (April 24, 2023): 3083. http://dx.doi.org/10.3390/jcm12093083.

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(1) Background: Heart failure with reduced ejection fraction (HFrEF) remains a major health burden. Angiotensin-Receptor-Neprilysin-Inhibitors (ARNIs) are an established HFrEF therapy which increases natriuretic peptide levels by inhibiting neprilysin. Leptin is a lipid metabolism parameter, which is also involved in glucose metabolism and is suggested to correlate with HF burden. While the hormone also seems to interact with neprilysin, potential associations with ARNI therapy have not been investigated yet. (2) Methods: To study this issue, we measured levels of leptin and fructosamine in consecutive 72 HFrEF patients before initiation of ARNI therapy and 3–6 months after initiation of therapy in two European centers. Biomarker levels were correlated with clinical parameters including ejection fraction, LVEF, and NYHA class. (3) Results: During a follow-up of up to 6 months, clinical parameters improved significantly (LVEF: 30.2 ± 7.8% to 37.6 ± 10.0%, (p < 0.001) and a significant improvement of the mean NYHA class with initial 32 patients in NYHA III or IV and 8 patients in NYHA class III/IV during the follow up (p < 0.001). The initial NT-proBNP levels of 2251.5 ± 2566.8 pg/mL significantly improved to 1416.7 ± 2145 pg/mL, p = 0.008) during follow up. ARNI therapy was also associated with an increase in leptin levels (17.5 ± 23.4 µg/L to 22.9 ± 29.3, p < 0.001) and furthermore, affected glucose metabolism indicated by elevation of fructosamine values (333.9 ± 156.8 µmol/L to 454.8 ± 197.8 µmol/L, p = 0.013). (4) Conclusion: while in the early phase of therapy, ARNI promotes clinical improvement of HFrEF, and it also seems to affect fat and glucose parameters, indicating significant metabolic implications of this therapy regime.
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Jadhav, Uday M., V. K. Chopra, S. Ray, and A. Oomman. "Initiation, Treatment Response Evaluation, and Safety Monitoring of Angiotensin Receptor/Neprilysin Inhibitors (Sacubitril/Valsartan) in the Management of Heart Failure in India: An Expert Group Recommendations." Journal of Indian College of Cardiology 13, no. 4 (2023): 141–46. http://dx.doi.org/10.4103/jicc.jicc_22_23.

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Angiotensin receptor/neprilysin inhibitors (ARNI) have become a pillar of heart failure (HF) management. Clinicians gain practical insight into the use of sacubitril/valsartan in patients with HF with reduced ejection fraction (EF) from a comprehensive overview based on clinical experience with ARNI therapy. The objective was to develop a consensus document addressing common concerns regarding the use of ARNI in patients with HF in clinical settings in India. Subject matter experts (SMEs) from India with decision-making expertise in the management of HF were identified to address experiences of ARNI use in Indian patients, its function in reversing myocardial remodeling, improvement in health status, and its safety. In regional meetings, five SMEs from India who consented to participate discussed data from practical experiences and current evidence. ARNI has been shown to substantially enhance EF 5%–10% in a majority of HF patients, although the range of improvement could vary widely in a few patients. Angiotensin-converting enzyme inhibitors and angiotensin II receptor blocker antagonists have been eclipsed by ARNI. Patients who have diminished or declining estimated glomerular filtration rates are more likely than those with normal renal function to experience hyperkalemia. It is prudent to consistently monitor potassium levels in patients with borderline chronic kidney disease. In India, potassium binders may be used to temporarily control hyperkalemia caused by ARNI. Patients with a systolic blood pressure of <100 mmHg may initiate taking ARNI while being tracked for clinical symptoms. In clinical practice, symptomatic improvement with ARNI is observed soon after initiating, even before alterations noted in echocardiography.
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Ishizaka, Mio, Yurika Yamamori, Huai-Hsun Hsu, Yuichi Miyagawa, Naoyuki Takemura, and Mizuki Ogawa-Yasumura. "Study on the Effects of Angiotensin Receptor/Neprilysin Inhibitors on Renal Haemodynamics in Healthy Dogs." International Journal of Molecular Sciences 25, no. 11 (June 3, 2024): 6169. http://dx.doi.org/10.3390/ijms25116169.

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An angiotensin receptor/neprilysin inhibitor (ARNI), a heart failure treatment, is a combination drug made up of sacubitril, a neprilysin inhibitor, and valsartan, a vascular receptor blocker. No human or veterinary studies regarding the effect of ARNI on renal haemodynamics in the absence of cardiac or renal issues exist. Therefore, we investigated the effect of ARNI on renal haemodynamics in five healthy dogs. ARNI was administered to all five dogs at an oral dose of 20 mg/kg twice daily for 4 weeks. Renal haemodynamics were assessed on the day before ARNI administration (BL), on Day 7, and on Day 28. The glomerular filtration rate (GFR) significantly increased on Day 28 compared to BL and Day 7, whereas renal plasma flow increased on Day 7 and Day 28 compared to BL. Systolic blood pressure significantly decreased between BL and Day 28. Plasma atrial natriuretic peptide (ANP) concentrations increased on Day 7 compared to BL. Additionally, ANP concentrations increased on Day 28 in three of the five dogs. Different ANP concentrations were observed in the remaining two dogs. Both urine output volume and heart rate remained relatively stable and did not exhibit significant change. In conclusion, ARNI may enhance renal haemodynamics in healthy dogs. ARNI could be a valuable drug for treating both heart and kidney disease in dogs.
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Einecke, Dirk. "Neue Therapieoption ARNI." MMW - Fortschritte der Medizin 158, no. 12 (June 2016): 70. http://dx.doi.org/10.1007/s15006-016-8461-0.

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Dissertations / Theses on the topic "ARNi"

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Segalotto, Matheus. "ARNI: an EEG-Based Model to Measure Program Comprehension." Universidade do Vale do Rio dos Sinos, 2018. http://www.repositorio.jesuita.org.br/handle/UNISINOS/7019.

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Submitted by JOSIANE SANTOS DE OLIVEIRA (josianeso) on 2018-04-24T13:44:05Z No. of bitstreams: 1 Matheus Segalotto_.pdf: 8717126 bytes, checksum: 94fda4721d448e49b82be91aaa8057c7 (MD5)
Made available in DSpace on 2018-04-24T13:44:05Z (GMT). No. of bitstreams: 1 Matheus Segalotto_.pdf: 8717126 bytes, checksum: 94fda4721d448e49b82be91aaa8057c7 (MD5) Previous issue date: 2018-01-18
CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
PROSUP - Programa de Suporte à Pós-Gradução de Instituições de Ensino Particulares
A compreensão de programa é um processo cognitivo realizado no cérebro dos desenvolvedores para entender o código-fonte. Este processo cognitivo pode ser influenciado por vários fatores, incluindo o nível de modularização do código-fonte e o nível de experiência dos desenvolvedores de software. A compreensão de programa é amplamente reconhecida como uma tarefa com problemas de erro e esforço. No entanto, pouco foi feito para medir o esforço cognitivo dos desenvolvedores para compreender o programa. Além disso, esses fatores influentes não são explorados no nível de esforço cognitivo na perspectiva dos desenvolvedores de software. Além disso, alguns modelos de cognição foram criados para detectar indicadores de atividade cerebral, bem como dispositivos de eletroencefalografia (EEG) para suportar essas detecções. Infelizmente, eles não são capazes de medir o esforço cognitivo. Este trabalho, portanto, propõe o ARNI, um modelo computacional baseado em EEG para medir a compreensão do programa. O modelo ARNI foi produzido com base em lacunas encontradas na literatura após um estudo de mapeamento sistemático (SMS), que analisou 1706 estudos, 12 dos quais foram escolhidos como estudos primários. Um experimento controlado com 35 desenvolvedores de software foi realizado para avaliar o modelo ARNI através de 350 cenários de compreensão de programa. Além disso, esse experimento também avaliou os efeitos da modularização e a experiência dos desenvolvedores no esforço cognitivo dos desenvolvedores. Os resultados obtidos sugerem que o modelo ARNI foi útil para medir o esforço cognitivo. O experimento controlado revelou que a compreensão do código fonte não modular exigia menos esforço temporal (34,11%) e produziu uma taxa de compreensão mais alta (33,65%) do que o código fonte modular. As principais contribuições são: (1) a execução de SMS no contexto estudado; (2) um modelo computacional para medir a compreensão do programa para medir o código-fonte; (3) conhecimento empírico sobre os efeitos da modularização no esforço cognitivo dos desenvolvedores. Finalmente, este trabalho pode ser visto como um primeiro passo para uma agenda ambiciosa na área de compreensão de programa.
Program comprehension is a cognitive process performed in the developers’ brain to understand source code. This cognitive process may be influenced by several factors, including the modularization level of source code and the experience level of software developers. The program comprehension is widely recognized as an error-prone and effort-consuming task. However, little has been done to measure developers’ cognitive effort to comprehend program. In addition, such influential factors are not explored at the cognitive effort level from the perspective of software developers. Additionally, some cognition models have been created to detect brain-activity indicators as well as wearable Electroencephalography (EEG) devices to support these detections. Unfortunately, they are not able to measure the cognitive effort. This work, therefore, proposes the ARNI, an EEG-Based computational model to measure program comprehension. The ARNI model was produced based on gaps found in the literature after a systematic mapping study (SMS), which reviewed 1706 studies, 12 of which were chosen as primary studies. A controlled experiment with 35 software developers was performed to evaluate the ARNI model through 350 scenarios of program comprehension. Moreover, this experiment also evaluated the effects of modularization and developers’ experience on the developers’ cognitive effort. The obtained results suggest that the ARNI model was useful to measure cognitive effort. The controlled experiment revealed that the comprehension of non-modular source code required less temporal effort (34.11%) and produced a higher correct comprehension rate (33.65%) than modular source code. The main contributions are: (1) the execution of SMS in the context studied; (2) a computational model to measure program comprehension to measure source code; (3) empirical knowledge about the effects of modularization on the developers’ cognitive effort. Finally, this work can be seen as a first step for an ambitious agenda in the area of program comprehension.
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Orbegozo, Ramírez Jeanette Paola. "Evaluación de la resistencia al virus de PLRV mediante el mecanismo de ARN de Interferencia (ARNi) en líneas transgénicas." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2012. https://hdl.handle.net/20.500.12672/576.

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El virus del enrollamiento de la papa (PLRV) es responsable de pérdidas severas en el rendimiento y calidad del cultivo de la papa en todo el mundo. Existen papas nativas y especies silvestres que presentan altos niveles de resistencia a PLRV (Solanum brevidens, S. tuberosum, S. chacoencse y S. raphanifolium). El desarrollo de nuevas variedades utilizando estas fuentes de resistencia es uno de los retos actuales del mejoramiento genético, sin embargo la naturaleza genética del cultivo de la papa que se desea mejorar es en la mayoría de los casos incompatible entre cultivos, sumándose a ello que la obtención de estos cultivos mejorados es cerca de 20 años. Por lo tanto la inserción directa de un gen que confiere resistencia a una variedad de importancia comercial tiene una ventaja muy significativa. En la presente tesis se evaluaron diez eventos (variedad Desiree) transformados con un constructo tipo hairpin que contenía el sistema de ARN de interferencia (ARNi), el cual mantiene activo y constante la formación del ARNdc entre las secuencias homólogas del transgen y el virus de PLRV. Los eventos fueron caracterizados por PCR y Southern blot, evidenciándose que tenían en su genoma entre una a dos copias del transgen. Los ensayos serológicos de DASELISA seleccionaron cuatro eventos con alta resistencia (bajas o nulas concentraciones del virus PLRV) durante su infección primaria, secundaria y terciaria. Finalmente, se determinó por Northern Blot que la resistencia a PLRV está relacionada con la presencia de los fragmentos pequeños de ARN (ARNsi) formados a partir del mecanismo de ARNi. -- PALABRAS CLAVE: Papa, transformación, PLRV, ARNi, ARNsi.
-- Potato Leafroll Virus (PLRV) is responsible for severe losses in yield and quality of potato worldwide. There are native and wild potatoes with high levels of resistance to PLRV (Solanum brevidens, S. etuberosum, and S. chacoencse raphanifolium).The development of new varieties using these sources of resistance is one of the current challenges of genetic improvement crop, however the genetic nature of the potato in most cases is incompatible between varieties, moreover to obtain the desired resistance takes over 20 years. Therefore the direct insertion of a gene that confers resistance to a variety of commercial importance have a significant advantage. The present thesis evaluated ten events (Desiree variety) transformed with a hairpin-type construct, containing the RNA interference system (RNAi), it will keep active and constant the formation of dsRNA between the homology sequence of transgene and PLRV. The events were characterized by PCR and Southern blot; they had in their genome from one to two copies of the transgene. Serological tests of DAS-ELISA selected four events with high resistance (low or zero concentrations of PLRV) during primary, secondary and tertiary infection. Finally, it was determined by Northern Blot that the resistance to PLRV is related to the presence of fragments of small interference RNA (siRNA) formed from the mechanism of RNAi. -- KEY WORDS: Potato, transformation, PLRV, RNAi, siRNA.
Tesis
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Presumey, Jessy. "Cibler les monocytes inflammatoires par ARNi pour une immunothérapie innovante des maladies autoimmunes." Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON1T017/document.

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Les monocytes inflammatoires Ly-6Chigh murins, et leurs homologues humains CD14+CD16-, jouent un rôle important dans l'initiation et la persistance des maladies inflammatoires chroniques. Leur action délétère dans ces pathologies a mené au développement de stratégies thérapeutiques visant à les éliminer ou empêcher leur recrutement aux sites inflammatoires. Toutefois, ces méthodes se sont avérées peu spécifiques des monocytes et surtout d'une faible efficacité compte tenu de l'aspect hautement inflammatoire des monocytes. Le besoin de développer de nouvelles stratégies est donc nécessaire. Les objectifs de ma thèse ont donc été dans un premier temps de caractériser in vivo le ciblage spécifique des monocytes inflammatoires par la formulation liposomale DMAPAP. Dans un second temps, l'utilisation de DMAPAP pour formuler des siRNA a permis d'évaluer l'efficacité thérapeutique d'une stratégie basée sur l'inhibition spécifique de gènes jouant un rôle clef dans l'inflammation dans les monocytes inflammatoires. Mon travail a permis de montrer dans un modèle préclinique d'arthrite que l'inhibition de gènes régulateurs de l'inflammation dans les monocytes Ly-6Chigh est une approche thérapeutique efficace permettant d'induire une immunomodulation des réponses pathogéniques des lymphocytes T effecteurs, aboutissant au défaut de recrutement des cellules immunitaires dans les articulations et à une amélioration des signes cliniques. J'ai également validé le transfert de cette technologie ex vivo sur cellules humaines primaires. L'inhibition de gènes clefs dans les monocytes inflammatoires représente donc une stratégie prometteuse pour le développement de futures thérapies dans la polyarthrite rhumatoïde. Par ailleurs, mes résultats confirment le rôle central des monocytes inflammatoires dans les pathologies inflammatoires chroniques
Inflammatory mouse Ly6Chigh monocyte subset and its human counterpart, defined as CD14+ CD16-, play key roles in the initiation and chronicization of immune-mediated inflammatory disorders (IMID). Deleterious effects of monocytes led to the development of therapeutic strategies aiming at depleting them or preventing their recruitment to inflamed tissues. However, these methods are poorly specific with weak efficacy considering the high number of inflammatory monocytes and their marked level of activation. The need for developing new therapeutic approaches is obvious. The aim of my thesis was to characterize selective delivery of a siRNA-containing lipid formulation to the Ly-6Chigh monocyte population and at evaluating the therapeutic potential of this targeted strategy. Using the cationic lipid-based DMAPAP vehicle for in vivo RNAi-mediated gene silencing, my work allowed demonstrating, in a preclinical mouse model of arthritis, the efficacy to inhibit master genes of inflammation specifically within Ly-6Chigh monocytes upon systemic injection. Reduced disease severity in mice was associated with an overall systemic immunomodulation of the pathogenic T cell populations and led to defective mobilization of immune cells to arthritic joints. Importantly, the formulation was successfully optimized in a perspective of clinical application and the targeting of human CD14+CD16- inflammatory monocytes was validated ex vivo. Overall, my findings demonstrate that the silencing of a key gene within Ly-6Chigh monocytes is a promising strategy for future therapeutic intervention in the context of IMID and reinforces the pivotal role of Ly-6Chigh monocytes in inflammatory processes
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Lavigne, Jennifer. "Caractérisation de l'hyperexcitabilité cérébrale dans des modèles murins d'épilepsies génétiques et développement d'une nouvelle stratégie pour la réduire." Thesis, Université Côte d'Azur (ComUE), 2016. http://www.theses.fr/2016AZUR4053/document.

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Mes travaux de thèse ont porté sur l’étude de deux modèles murins d’épilepsies génétiques de l’enfance liées à des mutations des canaux Nav1.1 (impliqués dans l’excitabilité des neurones inhibiteurs) : le Syndrome de Dravet (SD), une épilepsie pharmaco-résistante sévère, et l’Epilepsie Génétique avec Convulsions Fébriles Plus (EGCF+), présentant un phénotype plus modéré.Ils se sont décomposés en 3 axes : - La première partie mettant en évidence un phénomène d’épileptogenèse dans ces modèles murins.- La seconde permettant d’identifier des conditions expérimentales d’induction d'activités épileptiformes spécifiques du modèle murin du SD sur des tranches de cerveau.- La dernière consistant à mettre au point une stratégie pour réduire l’hyperexcitabilité cérébrale
During my thesis, I studied two murine models of childhood genetic epilepsies, caused by mutations of Nav1.1 channels (involved in the excitability of inhibitory neurons): Dravet Syndrome (DS), a severe and drug resistant epilepsy, and Genetic Epilepsy with Febrile Seizures Plus (GEFS+), characterized by a milder phenotype.My work is divided into three parts:- The first one revealed a process of epileptogenesis in these murine models.- In the second, I identified experimental conditions to induce epileptiform activities which are specific of the DS model in brain slices, which could allow pharmacological screens ex-vivo.- The third one was aimed at developing a new strategy to reduce cerebral hyperexcitability
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Lavigne, Jennifer. "Caractérisation de l'hyperexcitabilité cérébrale dans des modèles murins d'épilepsies génétiques et développement d'une nouvelle stratégie pour la réduire." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2016. http://theses.unice.fr/2016AZUR4053.

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Mes travaux de thèse ont porté sur l’étude de deux modèles murins d’épilepsies génétiques de l’enfance liées à des mutations des canaux Nav1.1 (impliqués dans l’excitabilité des neurones inhibiteurs) : le Syndrome de Dravet (SD), une épilepsie pharmaco-résistante sévère, et l’Epilepsie Génétique avec Convulsions Fébriles Plus (EGCF+), présentant un phénotype plus modéré.Ils se sont décomposés en 3 axes : - La première partie mettant en évidence un phénomène d’épileptogenèse dans ces modèles murins.- La seconde permettant d’identifier des conditions expérimentales d’induction d'activités épileptiformes spécifiques du modèle murin du SD sur des tranches de cerveau.- La dernière consistant à mettre au point une stratégie pour réduire l’hyperexcitabilité cérébrale
During my thesis, I studied two murine models of childhood genetic epilepsies, caused by mutations of Nav1.1 channels (involved in the excitability of inhibitory neurons): Dravet Syndrome (DS), a severe and drug resistant epilepsy, and Genetic Epilepsy with Febrile Seizures Plus (GEFS+), characterized by a milder phenotype.My work is divided into three parts:- The first one revealed a process of epileptogenesis in these murine models.- In the second, I identified experimental conditions to induce epileptiform activities which are specific of the DS model in brain slices, which could allow pharmacological screens ex-vivo.- The third one was aimed at developing a new strategy to reduce cerebral hyperexcitability
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Baron, Hylma Carolina. "Rôle de la protéine NSP3 dans la traduction de son propre ARN messager et sur la synthèse des autres protéines virales." Paris 11, 2008. http://www.theses.fr/2008PA114827.

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L’efficacité de la réplication virale dépend en grande partie de la capacité des virus à contourner l’appareil cellulaire à leur propre bénéfice. Pour compléter leur cycle viral, les virus synthétisent leurs protéines en utilisant la machinerie de traduction cellulaire. Dans le cas du Rotavirus, la traduction de ses ARNm, non polyadénylés mais coiffés à l’extrémité 5’, se réalise grâce à la protéine virale non structurale NSP3. Cette protéine reconnaît les 5 derniers nucléotides de l’extrémité 3’ des ARNm viraux, lesquels constituent une séquence consensus (UGACC dans le groupe A de Rotavirus). Cette protéine virale prend la place de la protéine polyA binding protein (PABP) dans le complexe de traduction cellulaire, permettant l’interaction entre les ARNm viraux et le facteur d’initiation de la traduction cellulaire eIF4G. La formation de ce complexe cependant va agir au détriment de la traduction des ARNm cellulaires. L’objectif de mon travail a été de confirmer le rôle essentiel de la protéine NSP3 dans la traduction des ARNm viraux. Pour cela, nous avons choisi de co-transfecter l’ARNm du gène 11 (codant NSP5) et l’ARNm de NSP3. Nos résultats montrent que la protéine NSP3 est indispensable pour la traduction des ARNm viraux mais également pour celle d’un gène rapporteur (Renilla luciférase). En effet nous avons montré que NSP3 est capable de se lier sur son propre ARNm afin de stimuler sa propre traduction et celle des autres protéines virales. Par ailleurs, nous avons montré en utilisant la technique des petits ARN interférents qu’une diminution de la quantité de NSP3 entraîne une diminution significative sur la synthèse des protéines virales et du pourcentage de cellules infectées tôt dans l’infection. Ces résultats confirment l’importance de NSP3 dans la traduction des ARNm viraux dans les premiers moments de l’infection. La seconde partie de ce travail a été consacrée à la recherche d’une voie alternative pour la traduction de l’ARN codant NSP3. Par la technique des ARNi interférents, nous avons inhibé l’expression du facteur de traduction eIF4GI et de la protéine DAP5 impliqués respectivement dans la traduction dépendante ou indépendante de la coiffe. Nous avons étudié aussi la phosphorylation du facteur eIF2a, un autre facteur impliqué dans la traduction des ARNm viraux. Enfin nous avons obtenus des résultats préliminaires sur l’influence des miRNA cellulaires sur la traduction des protéines de Rotavirus. Nos résultats montrent que les ARNm viraux de Rotavirus pourraient utiliser plusieurs voies alternativement ainsi que différents facteurs pour traduire ses propres ARNm
Rotavirus NSP3 binds simultaneously the 3’end of viral mRNAs and the translation initiation factors eIF4G and thus enhances viral mRNAs translation and impairs cell mRNAs translation. The role of NSP3 in rotavirus mRNA translation was further investigated by transfection of rotavirus mRNAs encoding NSP3 and NSP5 made in vitro. Using this assay, which mimics rotavirus infection, we show that the synthesis of NSP3 has a positive effect on its own expression and then allows efficient translation of the other rotavirus mRNA. Mutations in the RNA encoding NSP3 that impairs NSP3 binding to RNA or to eIF4G as well as mutation on the 3’ end of NSP3 own mRNA disrupt this positive effect, reduce NSP3 expression and reduce other rotavirus mRNA translation. Study by cell flow fluorometry of NSP3 expression at early time post infection confirms this observation. The expression of NSP3 during rotavirus infection preceed other viral proteins expression and lowering NSP3 expression by RNAi early reduce virus infection. Our work shows that the role of NSP3 in rotavirus translation is particularly important at the onset of infection when viral mRNAs have to compete with cellular mRNAs to reach the cell translation machinery
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Alwan, Rayan. "Criblage par ARN interférence pour l'identification de nouveaux gènes impliqués dans la différenciation myogénique." Thesis, Limoges, 2017. http://www.theses.fr/2017LIMO0015/document.

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La myogénèse est un processus multi-étapes hautement régulé impliquant la prolifération et la différenciation de myoblastes. Bien que la myogenèse ait été largement décrite, les mécanismes de régulation qui régissent ce processus complexe sont encore mal connus, notamment les réseaux de gènes et les interactions potentielles entre les voies de signalisation impliquées. Afin d'identifier de nouveaux gènes jouant un rôle dans la différenciation myogénique, j’ai mis en place un nouveau protocole in vitro, basé sur la lignée myoblastique C2C12, l’utilisation de l’ARN interférence et l'analyse quantitative d'images d'une grande quantité de myoblastes différenciés. J’ai pu inactiver une centaine de gènes et par une analyse quantitative de la densité cellulaire, de la quantité de myotubes, de la morphologie du myotube et de l'indice de fusion, j’ai pu montrer que six gènes parmi les 100 sont impliqués à la fois dans la prolifération et la différenciation des cellules C2C12 et 13 gènes jouant un rôle uniquement dans l’étape de différenciation. Nos résultats montrent que notre crible peut être un outil efficace pour détecter aussi bien les phénotypes subtils permettant l'identification de nouveaux régulateurs myogéniques chez les mammifères
Myogenesis is a highly regulated multi-step process involving myoblast proliferation and differentiation. Although studies over the last decades have identified several factors governing these distinct major phases, many of them are not yet known. In order to identify novel genes, we took advantage of the C2C12 myoblastic line to establish a functional siRNA screen combined with quantitative-imaging analysis of a large amount of differentiated myoblasts. We knocked down 100 mouse-preselected genes without a previously characterized role in muscle. Using image analysis, we tracked gene-silencing phenotypes by quantitative assessment of cellular density, myotube quantity, myotube morphology and fusion index. Our results have revealed six genes involved in both stages of C1C12 myogenesis and 13 genes specific to the differentiation stage. These findings prove that our RNAi-based screen could be an efficient tool to detect clear and subtle phenotypes allowing the identification of new myogenic regulators in Mammals
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Bergami, Francesco. "The glutamine-rich N-terminal extension of Drosophila AGO2 mediates antiviral RNA interference in a TRiC/CCT dependent manner." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ094.

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L’analyse par spectrométrie de masse des protéines qu’interagies avec Dicer-2, R2D2 a identifié six sur huit composés du complexe chaperon TRiC / CCT. L’élimination de l'un des six composants du complexe TRiC / CCT identifiés par spectrométrie de masse a conduit à une réplication virale accrue d'au moins un des trois virus testés. L’ensemble des mes résultats suggèrent un rôle nouveau pour le complexe TRiC / CCT dans l'ARNi antiviral. Mes résultats soulèvent la question de savoir pourquoi le GRR d’AGO2 semble être nécessaire dans le contexte d'une réponse antivirale. Mes résultats indiquent que le complexe TRiC / CCT participe à l’étape de dissociation et à la relocalisation dynamique d'AGO2-L pendant l’infection virale
The mass spectrometry analysis of the complexes associating with Dicer-2, R2D2, and AGO2 identified six out of the eight subunits forming the TRiC/CCT complex. Knockdown of one of the six subunits identified is sufficient to increase the replication of DCV (DrosophilaC Virus). My results identify an interaction between the TRiC/CCT complex and the antiviral RNA interference. This interaction raises the question of how the GRR region of AGO2 is necessary for the antiviral response. My results suggest that the TRiC/CCT complex is involved in the dynamic dissociation and relocalization of AGO2 during viral infection
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Stierlé, Vérène. "Reversion du phénotype de résistance multiple aux antitumoraux par les petits ARNs interférents." Paris 6, 2005. http://www.theses.fr/2005PA066612.

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Andrieu, Aurélie. "Explorer les voies de l’ARN interférence par initiation in planta pour dévoiler la fonction des gènes chez le riz (Oryza sativa L. ) et le cacaoyer (Theobroma cacao L. )." Montpellier 2, 2008. http://www.theses.fr/2008MON20174.

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Découvrir la fonction de l'ensemble des gènes végétaux est devenue une priorité depuis l'avènement des méthodes récentes de séquençage. Outre le nombre sans cesse croissant de génomes entièrement séquencés, à l'image de celui du riz, le nombre de séquences exprimées disponibles, ADNc et EST, est lui aussi en augmentation constante. C'est notamment le cas pour le cacaoyer (Theobroma cacao L. ) à travers un projet de séquençage d'EST réalisé au CIRAD Montpellier (Argout et al. , 2008), qui a permis de générer 149 650 ESTs. L'analyse bioinformatique de ces séquences a permis de repérer plusieurs gènes candidats potentiellement impliqués dans la résistance aux pathogènes, ou encore dans la qualité de la fève. La masse de données issue de ces programmes de séquençage nécessite maintenant de pouvoir disposer de méthodes efficaces à haut débit pour l'analyse fonctionnelle des gènes identifiés. Plusieurs techniques sont actuellement utilisées avec succès pour déterminer la fonction des gènes chez les plantes, mais la plupart d'entres elles impliquent l'utilisation de la transformation génétique stable, à l'image de la technologie d'inactivation de l'expression des gènes basée sur l'ARN interférence. Cette technique est couramment utilisée en génomique fonctionnelle car elle permet d'analyser avec efficacité et de manière ciblée la fonction des gènes. Ces travaux de thèse avaient pour objectif de développer un nouvel outil de génomique fonctionnelle permettant d'étudier la fonction des gènes avec efficacité et rapidité, sans avoir recours à la transformation génétique stable, en adaptant la technique d'agroinfection in planta pour initier et propager le mécanisme de l'ARNi dans la plante. La première étape de ces recherches a consisté à mettre au point une méthode d'expression transitoire de gènes dans les feuilles de riz et de cacaoyer par agro-infection. Si l'agro-infection in planta de cellules de feuilles de cacaoyer a été relativement aisée à obtenir en adaptant à cet arbre la méthode d'agro-infiltration de N. Benthamiana, aucune technique équivalente n'existait pour les céréales. L'agro-infection in planta du riz a donc nécessité de développer un protocole original, efficace et reproductible. Une fois la technique d'expression transitoire de gène validée pour ces deux espèces, des expériences d'extinction de gènes ciblées par ARNi ont été effectuées pour trois gènes endogènes pin1, chs et slr1, ainsi qu'un transgène gus pour le riz, et pour trois endogènes pin1, chs et pds pour le cacaoyer. Pour tous les gènes ciblés, il a été possible d'induire l'ARNi dans les cellules végétales. Après son initiation in planta, l'ARN interférence se maintient dans les tissus agro-infectés, ce qui conduit à une diffusion passive des siRNA dans les tissus situés autour de la zone agro-infectée, sans pour autant conduire à la mise en place d'un signal systémique permettant au mécanisme d'extinction de se propager dans l'organisme. Sur la base de ces résultats, une série d'expériences a été initié dans le tabac pour identifier les conditions nécessaires à la mise en place d'un tel signal systémique, et développer un nouveau protocole d'agro-infection des plantes d'intérêt
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Books on the topic "ARNi"

1

Haraldsson, Arni Rúnar. Arni Haraldsson: Firminy. Vancouver: Contemporary Art Gallery, 2001.

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1958-, Haraldsson Arni Rúnar, and London Regional Art and Historical Museums (Ont.), eds. At last sight: Arni Haraldsson. London, Ont: London Regional Art and Historical Museums, 2000.

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Studer, Paul. 150 Jahre Männerchor Arni: 1847-1997. [Arni: Männerchor, 1997.

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Hughes, Bethan. Beth am roi cynnig arni?: Llyfr gwaith llaw i blant. Capel Garmon: Gwasg Carreg Gwalch, 1991.

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Jayaraj, D. Socio-economic factors underlying growth of silk-weaving in the Arni region: A preliminary study. Chennai: Madras Institute of Development Studies, 2006.

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Haraldsson, Arni Rúnar. Arni Haraldsson: Projects on Vancouver architecture and landscape : Presentation House Gallery, Januaray 7 to February 19, 1995. Edited by Love Karen and Presentation House Gallery. North Vancouver: Presentation House Gallery, 1995.

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La Prussia in viaggio: Dalle armi alle arti. Venezia: Marsilio, 2019.

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Marin, Marino. Le Armi delle arti: Parlano i protagonisti dell'Anno italiano in Giappone. Milano, Italy: F. Angeli, 2003.

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Palazzo Baldeschi al Corso (Perugia, Italy), ed. Machiavelli e il mestiere delle armi: Guerra, arti e potere nell'Umbria del Rinascimento. Passignano s.T. (Perugia): Aguaplano, 2014.

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Parkkinen, Marja-Leena. Love Armi: Armi Ratian henkilökuva. Helsingissä: Otava, 2005.

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Book chapters on the topic "ARNi"

1

Bihlmaier, Andreas, Matthias Hadlich, and Heinz Wörn. "Advanced ROS Network Introspection (ARNI)." In Studies in Computational Intelligence, 651–70. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-26054-9_25.

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Hüttner, W. "37 ArNi Nickel – argon (1/1)." In Diamagnetic Diatomic Molecules. Part 1, 58. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-69954-5_39.

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Lawford, James P. "Arcot, Arni and Kauveripauk 1751–2." In Clive, Proconsul of India, 100–121. London: Routledge, 2023. http://dx.doi.org/10.4324/9781003359067-5.

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Bayala, Eric. "Transformative Effects of Remittances on Health Behavior, Community Resilience, and Gender Dynamics in Burkina Faso." In Remittances as Social Practices and Agents of Change, 227–47. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-030-81504-2_10.

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AbstractFor five decades, the village of Niaogho in the Centre-Est region of Burkina Faso has faced an outmigration to Italy. Together with its local partner “Association pour le Developpement de Niaogho” (ADN), the hometown association called “Association pour le Devéloppement Niaogho en Italie” (ARNI) initiated health infrastructure projects in Niaogho. By applying a cross-sectional study using household surveys and interviews, this chapter examines the effects of the diaspora’s individual (household level) and collective (community level) remittances on health behavior, community resilience, and gender dynamics in Niaogho.The findings show that the ARNI projects and especially the activities of its women’s section contributed to better access to health infrastructure and enhanced prenatal and postnatal care through the transfer of bonding and bridging social capital. Overall, community resilience in Niaogho improved, but at the same time, the dependency on financial remittances increased, reducing self-determined initiatives and especially affecting the women left behind.
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Christen, Dines. "Molecular Constants of ArNi (Ground-State Unassigned) Argon-Nickel (1/1) Dimer." In Molecular Constants Mostly from Microwave, Molecular Beam, and Sub-Doppler Laser Spectroscopy, 75–76. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49199-7_23.

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Basile, Elisabetta. "The Impact of Caste on Production Relations in Arni: A Gramscian Analysis." In Exploring Urban Change in South Asia, 151–76. New Delhi: Springer India, 2016. http://dx.doi.org/10.1007/978-81-322-2431-0_6.

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Arivukkarasi, N. A. "The Making and Unmaking of Handloom Silk Weaving in the Arni Region." In Exploring Urban Change in South Asia, 201–27. New Delhi: Springer India, 2016. http://dx.doi.org/10.1007/978-81-322-2431-0_8.

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Brunner-La Rocca, Hans-Peter. "Pharmacotherapy in Heart Failure (I): Renin-Angiotensin-Aldosterone System (incl. ARNI), Diuretics, Digoxin and Statins." In Heart Failure, 105–20. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-98184-0_7.

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Basile, Elisabetta. "Local-Global Integration, Diversification and Informality: Long-Term Change in Arni During the Late Twentieth Century." In Exploring Urban Change in South Asia, 29–64. New Delhi: Springer India, 2016. http://dx.doi.org/10.1007/978-81-322-2431-0_2.

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Harriss-White, Barbara. "Epilogue—The Future for Small Towns: The Case of Arni—or Ambur or Ranipet or Tiruppur or …?" In Exploring Urban Change in South Asia, 275–84. New Delhi: Springer India, 2016. http://dx.doi.org/10.1007/978-81-322-2431-0_11.

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Conference papers on the topic "ARNi"

1

O’Connor, C., J. Kumar, N. Caples, E. Cronin, S. Asgedom, P. O’Callaghan, and P. Owens. "47 Arni ‘terminates’ traditional heart failure treatment." In Irish Cardiac Society Annual Scientific Meeting & AGM, Thursday October 4th – Saturday October 6th 2018, Galway Bay Hotel, Galway, Ireland. BMJ Publishing Group Ltd and British Cardiovascular Society, 2018. http://dx.doi.org/10.1136/heartjnl-2018-ics.47.

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Kylliäinen, M. "International Networks of Finnish Acoustician Paavo Arni." In 10th Convention of the European Acoustics Association Forum Acusticum 2023. Turin, Italy: European Acoustics Association, 2022. http://dx.doi.org/10.61782/fa.2023.0274.

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Wahyudhi, Candra, Irfan Muafa, and Muhammad Awal. "Utilizing Instagram As A Promotional Media By Small And Medium Enterprises (SME) Arni Kripik Merauke." In Proceedings of the International Conference on Social Science 2019 (ICSS 2019). Paris, France: Atlantis Press, 2019. http://dx.doi.org/10.2991/icss-19.2019.199.

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Ledwidge, M., RB Pharithi, F. Ryan, J. Dodd, D. Murphy, J. Gallagher, C. Watson, M. Barrett, K. McDonald, and M. Ferre. "20 Progression of doppler-echocardiographic markers of structure and function in the personalised prospective comparison of arni with arb in patients with natriuretic peptide elevation (PARABLE) randomized controlled trial." In Irish Cardiac Society Annual Scientific Meeting & AGM, Thursday October 17th – Saturday October 19th 2019, Galway, Ireland. BMJ Publishing Group Ltd and British Cardiovascular Society, 2019. http://dx.doi.org/10.1136/heartjnl-2019-ics.20.

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Saunders, Steven, and Lawrence Rauchwerger. "ARMI." In the ninth ACM SIGPLAN symposium. New York, New York, USA: ACM Press, 2003. http://dx.doi.org/10.1145/781498.781534.

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Knapp, Andreas, Ricarda Wernitz, Christoph Eichhorn, Hannes Fulge, Georg Herdrich, Stefan Lohle, Stefanos Fasoulas, Monika Auweter-Kurtz, and Hans-Peter Roser. "Emission Spectroscopic Investigation of the Radial Distribution of ArI und ArII in Argon Plasma Flows under the Influence of Magnetic Field." In 42nd AIAA Plasmadynamics and Lasers Conference. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2011. http://dx.doi.org/10.2514/6.2011-3455.

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Cheatham, Jesse, Bao Truong, Nicholas Touran, Ryan Latta, Mark Reed, and Robert Petroski. "Fast Reactor Design Using the Advanced Reactor Modeling Interface." In 2013 21st International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icone21-16815.

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The Advanced Reactor Modeling Interface (ARMI) code system has been developed at TerraPower to enable rapid and robust core design. ARMI is a modular modeling framework that loosely couples nuclear reactor simulations to provide high-fidelity system analysis in a highly automated fashion. Using a unified description of the reactor as input, a wide variety of independent modules run sequentially within ARMI. Some directly calculate results, while others write inputs for external simulation tools, execute them, and then process the results and update the state of the ARMI model. By using a standardized framework, a single design change, such as the modification of the fuel pin diameter, is seamlessly translated to every module involved in the full analysis; bypassing error-prone multi-analyst, multi-code approaches. Incorporating global flux and depletion solvers, subchannel thermal-hydraulics codes, pin-level power and flux reconstruction methods, detailed fuel cycle and history tracking systems, finite element-based fuel performance coupling, reactivity coefficient generation, SASSYS-1/SAS4A transient modeling, control rod worth routines, and multi-objective optimization engines, ARMI allows “one click” steady-state and transient assessments throughout the reactor lifetime by a single user. This capability allows a user to work on the full-system design iterations required for reactor performance optimizations that has traditionally required the close attention of a multi-disciplinary team. Through the ARMI framework, a single user can quickly explore a design concept and then consult the multi-disciplinary team for model validation and design improvements. This system is in full production use for reactor design at TerraPower, and some of its capabilities are demonstrated in this paper by looking at how design perturbations in fast reactor core assemblies affect steady-state performance at equilibrium as well as transient performance. Additionally, the pin-power profile is examined in the high flux gradient portion of the core to show the impact of the perturbations on pin peaking factors.
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Ramingwong, Sakgasit, and Lachana Ramingwong. "ARMI: A risk management incorporation." In 2014 11th International Conference on Electrical Engineering/Electronics, Computer, Telecommunications and Information Technology (ECTI-CON). IEEE, 2014. http://dx.doi.org/10.1109/ecticon.2014.6839802.

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Otter, Gerard C. J., James Day, Eugenio Di Iorio, Marcela Pelica Páscoa, Bart Speet, Niels Dijkhuizen, Ralph Snel, and Oana van der Togt. "Absolute radiometric reference instrument (ARRI)." In Sensors, Systems, and Next-Generation Satellites XXV, edited by Steven P. Neeck, Toshiyoshi Kimura, Sachidananda R. Babu, and Arnaud Hélière. SPIE, 2021. http://dx.doi.org/10.1117/12.2596228.

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Renda, Giovanni, Maurizio Masera, Maurizio Martina, and Guido Masera. "Approximate Arai DCT Architecture for HEVC." In 2017 New Generation of CAS (NGCAS). IEEE, 2017. http://dx.doi.org/10.1109/ngcas.2017.38.

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Reports on the topic "ARNi"

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Franco, Susana, Ander Sánchez, and James Wilson. Euskal Autonomia Erkidegoko ekonomia eta gizarte digitalak. DESI 2023. Edited by Patricia Canto. Universidad de Deusto, 2024. http://dx.doi.org/10.18543/lsup3952.

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"Euskal Autonomia Erkidegoko Ekonomia eta Gizarte Digitalak. DESI 2023" txostenaren aurtengo edizioa Europako Batzordeak Hamarkada Digitalaren testuinguruan garatu duen metodologia berrira egokitu dugu, Euskal Autonomia Erkidegoaren bilakaera Europar Batasuneko estatu kideenarekin alderatuko duen diagnostikoa egiteko, 4 dimentsiok osatutako panela erabiliz: (i) gaitasun digitalak; (ii) azpiegitura digitalak; (iii) enpresen eraldaketa digitala; eta (iv) zerbitzu publikoen digitalizazioa. Analisiaren emaitzek erakusten dute Euskal Autonomia Erkidegoak hobera egin duela adierazle guztietan. Horrek erakusten du gure ekonomiaren eta gizartearen digitalizazioan etengabe ari garela aurrera egiten. Hala ere, adierazleen gorakada joera orokorra da lurralde guztietan, eta, horregatik, Euskal Autonomia Erkidegoak gainerako lurraldeekiko duen kokapenak eta kokapen horren azken urteetako bilakaerak argi-ilunak eta ñabardurak ditu dimentsioetako bakoitzean.
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WESTAT INC ROCKVILLE MD. The 1985 ARI Survey of Army Recruits: Codebook for Summer 85 USAR and ARNG Survey Respondents. Volume 2. Fort Belvoir, VA: Defense Technical Information Center, May 1986. http://dx.doi.org/10.21236/ada171961.

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Calm, J. M. ARTI refrigerant database. Office of Scientific and Technical Information (OSTI), January 1999. http://dx.doi.org/10.2172/334263.

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Calm, J. M. ARTI Refrigerant Database. Office of Scientific and Technical Information (OSTI), February 1995. http://dx.doi.org/10.2172/35387.

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Calm, J. M. ARTI refrigerant database. Office of Scientific and Technical Information (OSTI), July 1996. http://dx.doi.org/10.2172/366496.

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Calm, J. M. ARTI refrigerant database. Office of Scientific and Technical Information (OSTI), February 1997. http://dx.doi.org/10.2172/463612.

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Calm, J. M. ARTI refrigerant database. Office of Scientific and Technical Information (OSTI), November 1996. http://dx.doi.org/10.2172/418455.

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Calm, J. M. ARTI refrigerant database. Office of Scientific and Technical Information (OSTI), August 1998. http://dx.doi.org/10.2172/674946.

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Calm, J. M. ARTI Refrigerant Database. Office of Scientific and Technical Information (OSTI), April 1992. http://dx.doi.org/10.2172/10153986.

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Cain, J. M. ARTI Refrigerant Database. Office of Scientific and Technical Information (OSTI), April 1993. http://dx.doi.org/10.2172/10156499.

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