Academic literature on the topic 'Arnim Family'

AbstractIn partial answer to a question posed by Arnie Miller [4] and X. Caicedo [2] we obtain sufficient conditions for an ℒω1,ω theory to have an independent axiomatization. As a consequence we obtain two corollaries: The first, assuming Vaught's Conjecture, every ℒω1,ω theory in a countable language has an independent axiomatization. The second, this time outright in ZFC, every intersection of a family of Borel sets can be formed as the intersection of a family of independent Borel sets.

<p class="MsoNormal" style="text-align: justify; margin: 0cm 0cm 6pt;"><span style="mso-ansi-language: EN-US;" lang="EN-US"><span style="font-size: small;"><span style="font-family: Calibri;">Professor Remy Presas was the founder of a style of martial arts called Modern Arnis. The Professor brought this knowledge and his own innovations to the U.S.A. and the rest of the world beginning in the mid-1970s, and was one of four headmasters who formed an alliance, sharing ideas and students throughout the decades that followed. Professor Presas died before being interviewed for this series, so this retrospective is comprised of the stories and memories of many of those who knew and loved him.</span></span></span></p>

Appreciated among Latin Americanists in the United States and highly regarded in Chile, Arnold (“Arnie”) Bauer taught history at the University of California at Davis from 1970 to 2005, and was director of the University of California's Education Abroad Program in Santiago, Chile, for five years between 1994 and 2005. Well-known for his engaging writing style, Bauer reflects broad interests in his publications: agrarian history (Chilean Rural Society: From the Spanish Conquest to 1930 [1975]), the Catholic Church and society (as editor, La iglesia en la economía de América Latina, siglos XIX-XIX [1986]), and material culture (Goods, Power, History: Latin America's Material Culture [2001]). He has also written an academic mystery regarding a sixteenth-century Mexican codex, The Search for the Codex Cardona (2009). His coming-of-age memoir (Time's Shadow: Remembering a Family Farm in Kansas [2012]) describes his childhood and was recently named one of the top five books of 2012 by The Atlantic. He has also written some 50 articles and book chapters and more than 60 book reviews.

Appreciated among Latin Americanists in the United States and highly regarded in Chile, Arnold (“Arnie”) Bauer taught history at the University of California at Davis from 1970 to 2005, and was director of the University of California's Education Abroad Program in Santiago, Chile, for five years between 1994 and 2005. Well-known for his engaging writing style, Bauer reflects broad interests in his publications: agrarian history (Chilean Rural Society: From the Spanish Conquest to 1930 [1975]), the Catholic Church and society (as editor, La iglesia en la economía de América Latina, siglos XIX-XIX [1986]), and material culture (Goods, Power, History: Latin America's Material Culture [2001]). He has also written an academic mystery regarding a sixteenth-century Mexican codex, The Search for the Codex Cardona (2009). His coming-of-age memoir (Time's Shadow: Remembering a Family Farm in Kansas [2012]) describes his childhood and was recently named one of the top five books of 2012 by The Atlantic. He has also written some 50 articles and book chapters and more than 60 book reviews.

Alzheimer’s disease (AD) is the most common type of dementia in the elderly. It is associated to a progressive loss of memory, problems in learning and behaviour changes. This disease is characterized by the accumulation of extracellular amyloid β (Aβ) aggregates and intracellular deposits of hyperphosphorylated Tau protein. Both aggregates trigger neuronal apoptosis and glial inflammation, leading to the cognitive decline found in AD patients. Interestingly, the serine protease tissue plasminogen activator (tPA), which is induced by Aβ, has been found to play a dual, dose-dependent role in the disease. Physiological levels of tPA confers neuroprotection through plasmin generation and Aβ degradation. In contrast, high doses of tPA activate intracellular signalling pathways in neurons and glial cells, inducing neuronal apoptosis and inflammation. However, the molecular mechanisms that govern the regulation of tPA expression in AD have still not been fully elucidated. In this work, we demonstrate that Aβ-induced tPA expression is regulated by translational control. In particular, our results show that CPEB1 and CPEB4, two members of the cytoplasmic polyadenylation element binding protein (CPEB) family of RNA-binding proteins, control local tPA synthesis in response to Aβ. Specifically, Aβ promotes tPA mRNA translation in the dendritic spines through synaptic polyadenylation and synaptic cleavage and polyadenylation, a mechanism that is impaired in the absence of CPEB1 or CPEB4. Our results also demonstrate that the pre-mRNA 3'-end processing machinery required for the efficient cleavage and polyadenylation of mRNAs is also present in the synaptic terminals. Finally, we have found that, similarly to tPA, CPEB4 is upregulated in the synaptic terminals in response Aβ and in vivo in the brain of AD patients.
La enfermedad de Alzheimer (EA) es la demencia más común en la tercera edad. Está asociada a una pérdida progresiva de memoria, problemas de aprendizaje y cambios de comportamiento. Esta enfermedad se caracteriza por la acumulación de agregados extracelulares de proteína β-amiloide (Aβ) y depósitos intracelulares de proteína Tau hiperfosforilada. Ambos agregados inducen apoptosis neuronal e inflamación mediada por las células de la glia, lo cual desencadena el declive cognitivo característico de los enfermos de EA. En este sentido, se ha demostrado que una serina proteasa, el activador del plasminógeno tisular (del inglés "tissue plasminogen activator", tPA), cuya expresión se induce por Aβ, juega un doble papel clave en la enfermedad en función de sus niveles. Por un lado, unos niveles fisiológicos de tPA pueden ser neuroprotectores a través de la generación de plasmina, con la consiguiente degradación del Aβ. Por otro lado, unos niveles altos de tPA activan cascadas de señalización intracelular en neuronas y células de la glia, lo que induce apoptosis neuronal e inflamación. Los mecanismos moleculares que rigen la regulación de la expresión de tPA en la EA no se conocen con claridad. En este trabajo, demostramos que la expresión de tPA inducida por Aβ está regulada por control traducional. En concreto, nuestros resultados muestran que CPEB1 y CPEB4, dos miembros de la familia CPEB de proteínas de unión a RNA (del inglés "cytoplasmic polyadenylation element binding, CPEB), controlan la síntesis de tPA en respuesta a Aβ. Concretamente, el Aβ promueve la traducción del ARNm de tPA en las espinas sinápticas a través de poliadenilación sináptica, y procesamiento y poliadenilación alternativos sinápticos, un mecanismo que se ve interrumpido en ausencia de CPEB1 o CPEB4. Nuestros resultados también demuestran que la maquinaria de procesamiento de los extremos 3' del pre-ARNm necesaria para llevar a cabo este proceso está presente en los terminales sinápticos. Por último, hemos encontrado que, al igual que tPA, CPEB4 se sobreexpresa en los terminales sinápticos en respuesta a Aβ, así como en el cerebro de pacientes con EA.

La famille de l'inter-α-inhibiteur regroupe des protéines plasmatiques issues de divers assemblages de trois chaînes lourdes H1, H2, H3, et d'une chaîne légère appelée bikunine. La bikunine et l'α-1-microglobuline sont issues d'un précurseur commun dénommé α-1-microglobulin/bikunin precursor (AMBP). L'α-1-microglobuline appartient a la superfamille des lipocalines. La technique d'électrophorèse en champs pulsés a localisé le gène AMBP à moins de 300 kb du gène orosomucoïde, sur le chromosome 4 de la souris. Par une étude de linkage, quatre autres gènes codant pour des lipocalines (oncogène 24p3, protéine PP14, chaîne γ du composant C8 du complément et prostaglandine-D-synthase) ont été localisés sur le Chr 2 de la souris. Les quatre ADNc murins ont été clonés, puis séquencés; l'analyse de ces séquences a montré que les chaînes H1 et H3 présentent le motif consensus de type multicopper oxydase de type I. Une étude de l'expression tissulaire, effectuée chez le rat et la souris par Northern blot et RT-PCR, a montré que ces quatre gènes sont spécifiques du foie, à l'exception de H2 et H3 observés également dans le cerveau. La transcription de ces quatre gènes, au cours de l'ontogenèse, est coordonnée dans le temps avec une augmentation progressive et un pic transitoire obtenu à 5 jours post-partum. Ces variations correspondent à des modifications transcriptionnelles. Au cours d'une expérience d'induction de l'inflammation aiguë, il y a diminution de l'expression des gènes de la famille inter-α-inhibiteur. Les produits de ces quatre gènes sont donc régulés de façon négative et font partie du groupe des protéines dites négatives de la phase aiguë

This chapter traces literary influence Katherine Mansfield and Elizabeth von Arnim, writers who were artistic contemporaries, cousins and friends. It explores the relationship between kinship and literary influence: Elizabeth von Arnim was an early influence on Mansfield, prompted by their close family ties, and von Arnim’s Elizabeth novels clearly influenced Mansfield's In a German Pension (1911). Yet family identification can also threaten personal relationships, particularly when one writer enjoys more success than the other due to the adoption of different artistic ideologies and practices. Familial rivalry can itself, however, work as inspiration, revealed in the correspondence between Mansfield and von Arnim.

Like many women, Katherine Mansfield and Elizabeth von Arnim lost members of their immediate family in the Great War, and both writers worked through their loss in writing. Although their work is stylistically and thematically different, the expressions of grief in their work shares certain characteristics with other (post-)war writing. This article examines the literary responses to personal to loss in von Arnim’s novels Christine and In the Mountains, as well as Mansfield’s New Zealand stories and “The Fly” with the help of their private diaries and letters.

Katherine Mansfield’s claim that she and Elizabeth von Arnim are ‘worms of the same family’ would seem a curious analogy. But this deprecatory trope aligning the writer’s perspective with an insect’s, nonetheless, uses commonly held assumptions to interrogate gendered subjectivity and class dichotomies in the postwar world. In ‘The Fly,’ Mansfield depicts a businessman distracted by the seemingly harmless entertainment of dousing a housefly with ink; his god-like play with the fly evokes an attempt to master trauma – the loss of his son in the war, his consequent lack of purpose, and his complicity. Likewise, Mabel Waring in Virginia Woolf’s ‘The New Dress’ compulsively repeats an image she’s conjured of a fly crossing a saucer as a bulwark against the sense of irrelevance she feels in upper-class society. In Kangaroo, D.H. Lawrence’s writer Richard Somers faces a dark night of the soul trying on and rejecting different ideologies in order to secure a sense of purpose in his work; he sees himself as a fly harrowingly climbing up and continually falling back into a pot of ointment. Each protagonist considers or takes on the point of view of a housefly, attempting to master a trauma that, seen fully, would threaten his or her identity. These scenes should be an affective climax, however, as the deprecating choice of a housefly suggests, they are instead moments not of epiphany or emotional release but of existential impasse.