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Dissertations / Theses on the topic 'Aromatic amino'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Banerji, Suneale. "Aromatic amino acid biosynthesis in Pneumocystis carinii." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336091.

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2

Salter, M. "Aromatic amino acid metabolism in the rat liver." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374780.

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3

Ploetz, Elizabeth Anne. "A Kirkwood-Buff force field for aromatic amino acids." Thesis, Manhattan, Kan. : Kansas State University, 2010. http://hdl.handle.net/2097/4028.

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4

Krappmann, Sven Kurt. "Biosynthesis of Aromatic Amino Acids in Yeast and Aspergillus." Doctoral thesis, [S.l. : s.n.], 2000. http://hdl.handle.net/11858/00-1735-0000-000D-F20C-1.

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5

Brown, Judy Forsyth. "Regulation in aromatic amino acid biosynthesis in Saccharomyces cerevisiae." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/12947.

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6

Ikeda, Masato. "Molecular Breeding of Aromatic Amino Acid-Producing Corynebacterium glutamicum." Kyoto University, 1995. http://hdl.handle.net/2433/160852.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(農学)<br>乙第8803号<br>論農博第1966号<br>新制||農||695(附属図書館)<br>学位論文||H7||N2779(農学部図書室)<br>UT51-95-B268<br>(主査)教授駒野徹, 教授大山莞爾, 教授加藤暢夫<br>学位規則第4条第2項該当

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7

Shen, Bin. "Studies on the nucleophilic aromatic 18 F-Fluorination from model compounds to aromatic amino acids /." [S.l. : s.n.], 2008.

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8

Allen, G. F. G. "The neurochemical consequences of aromatic L-amino acid decarboxylase deficiency." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1310134/.

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Aromatic L-amino acid decarboxylase (AADC) catalyses the conversion of 5-hydroxytryptophan (5-HTP) and L-3,4-dihydroxyphenylalanine (L-dopa) to the neurotransmitters serotonin and dopamine respectively. The inherited disorder AADC deficiency leads to a severe deficit of serotonin and dopamine as well as an accumulation of 5-HTP and L-dopa. This thesis investigated the potential role of 5-HTP/L-dopa accumulation in the pathogenesis of AADC deficiency. Treatment of human neuroblastoma cells with L-dopa or dopamine was found to increase intracellular levels of the antioxidant reduced glutathione

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9

Stuart, Fiona. "An investigation of aromatic amino acid biosynthesis in Streptomyces rimosus." Thesis, University of Glasgow, 1990. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506454.

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10

Liang, Jing. "Biochemical Studies of Aromatic Amino Acid Decarboxylases and Acetaldehyde Synthases." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/96242.

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Pyridoxal 5'-phosphate (PLP)-dependent enzymes widely exist in most living organisms from bacteria to human. Among different types of PLP-dependent enzymes, aromatic amino acid decarboxylases play critical physiological roles because many aromatic amines are essential neurotransmitters. This dissertation concerns the biochemical characterization of several PLP-dependent decarboxylases and aims to understand the structure-function relationships, especially critical residues involved in their catalysis. We first present an overview of the current opinions and recent advances in structure-functio

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11

Butchosa, Robles Cristina. "Computational modeling of charge transfer in nucleobase-aromatic amino acid complexes." Doctoral thesis, Universitat de Girona, 2012. http://hdl.handle.net/10803/83529.

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The present thesis models nucleobase-amino acid charge transfer reactions, which can serve as base for future computational investigations of charge transfer processes in DNA-protein systems. Guanine and adenine charge transfer reactions with aromatic amino acids (histidine, phenylalanine, tryptophan, and tyrosine) have been studied. Both pi-stacked and T-shaped nucleobase-aromatic amino acid interactions have been found to produce fast charge transfer rates. Most of the aromatic amino acids are able to extract charges from DNA. Special attention has been paid to tryptophan because its redox p

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12

Gulko, Miriam Kolog. "A non-canonical pathway for aromatic amino acid biosynthesis in haloarchea." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-131276.

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13

Fisher, Andrew. "Pharmacological manipulation of aromatic L-amino acid decarboxylase in the rat." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325114.

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14

Walton, Curtis James William. "Engineering Aminotransferases for the Biocatalytic Production of Aromatic D-Amino Acids." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37929.

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Optically pure aromatic D-amino acids, such as D-phenylalanine (D-Phe) and its derivatives, are high-value building blocks for the pharmaceutical industry. These compounds can be prepared using biocatalytic methods relying on various enzymes, including aminotransferases (ATs). ATs, also called transaminases (EC 2.6.1.X), are a subclass of pyridoxal 5′-phosphate-dependent enzymes that catalyze the transfer of the amino group from a donor substrate to a ketone acceptor. Synthesis of optically-pure amino acids using whole-cell biocatalytic cascades based on ATs possess several advantages compared

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15

Ouellette, Mélanie. "Gas-phase Ion Chemistry of Hydroxy and Amino-substituted Interstellar Polycyclic Aromatic Hydrocarbons and Protonated Polycyclic Aromatic Hydrocarbons." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31349.

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The gas-phase ion chemistry of hydroxyl- and amino-substituted polycyclic aromatic hydrocarbons (PAHs) and their protonated counterparts were studied using mass spectrometry. Ions were generated using an electron ionization (EI) source and the unimolecular chemistry of metastable ions was studied by performing mass-analysed ion kinetic energy spectrometry (MIKES) experiments with a magnetic sector tandem mass spectrometer. Collision-induced dissociation (CID) experiments were used in conjunction with MIKES experiments to determine ion structure. The ten molecules studied were: 1-naphthol, 2-na

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16

Yeatts, Karin Beatrice. "An investigation of structure activity relationships for aryl nitrenium stability and mutagenicity for amino polyaromatic hydrocarbons." Thesis, This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-02132009-170829/.

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17

Phillips, Susan R. "Spectroscopic investigation of tryptophan microenvironments in bovine lens proteins." Diss., Georgia Institute of Technology, 1986. http://hdl.handle.net/1853/32973.

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18

Gartland, Martin John. "Site-directed mutagenesis of the aromatic amino acid aminotransferase of Escherichia coli." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293014.

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19

Alexander, Janet Elizabeth. "Construction and characterisation of aromatic amino acid dependent mutants of Listeria monocytogenes." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/35379.

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The severe forms of listeriosis, have a very high mortality rate. In farm animals, especially sheep, these losses can be of considerable economic importance. The increase in cases of listeriosis in both man and animals over the last decade has stimulated research to develop an effective vaccine to protect against Listeria monocytogenes. However, attempts at protection using killed or chemically attenuated live vaccines have been disappointing. An alternative to these procedures is the development of strains with a defined mechanism of attenuation. Attempts were made to construct aromatic amino

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20

Kocabas, Pinar. "Aromatic Synthesis Performance Of Bacillus Acidocaldarius." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/2/12605176/index.pdf.

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In this study, the effects of bioprocess operation parameters on aromatic amino acid synthesis performance of Bacillus acidocaldarius were investigated. Firstly, in laboratory scale shake-bioreactors, a defined medium was designed in terms of its carbon and nitrogen sources, to achieve the highest cell concentration. Thereafter, the effects of bioprocess operation parameters, i.e., pH and temperature were investigated<br>and the optimum medium contained (kg m-3): fructose, 8<br>(NH4)2HPO4, 5<br>CaCl2, 0.2<br>KH2PO4, 2<br>NaH2PO4.2H2O, 7.318<br>Na2HPO4, 0.0438<br>Mg(CH3COO)2.4H2O, 87&times<br>1

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21

Spence, Michael Patrick. "Plant aromatic amino acid decarboxylases: Evolutionary divergence, physiological function, structure function relationships and biochemical properties." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/49432.

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Plant aromatic amino acid decarboxylases (AAADs) are a group of economically important enzymes categorically joined through their pyridoxal 5'-phosphate (PLP) dependence and sequence homology. Extensive evolutionary divergence of this enzyme family has resulted in a selection of enzymes with stringent aromatic amino acid substrate specificities. Variations in substrate specificities enable individual enzymes to catalyze key reactions in a diverse set of pathways impacting the synthesis of monoterpenoid indole alkaloids (including the pharmacologically active vinblastine and quinine), benzyliso

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22

Hepworth, Peter. "Conformational analysis via LIF spectroscopy of jet cooled molecules : hydroxy- and amino-benzoic acid esters." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335925.

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23

El-Sayed, Mohamed. "Functional Aromatic Amino Ketones as UV/Vis probes for various liquid and solid environments." Doctoral thesis, Universitätsbibliothek Chemnitz, 2003. http://nbn-resolving.de/urn:nbn:de:swb:ch1-200300948.

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Zum gegenwärtigen Kenntnisstand bezüglich Solvatochromie, Sol-Gel Prozesse, und der Synthese von Polyketonen wird eine kurze Einführung gegeben. Die Synthesekonzeptionen funktionalisierter aromatischer Aminoketone wereden vorgestellt. Die neun Verbindungen wurden mittels Elementaranalyse, Röntgenstrukturanalyse, und spektroskopischen (NMR, UV/Vis, MS) Methoden aufgeklärt. Im Mittelpunkt der Untersuchungen steht die Untersuchung des Einflusses von unterschiedlichen Medien (Lösungmittel, Oberflächen, Sol-Gel Materialien und Nachbarnmoleküle im Kristall) auf die Lage der UV/Vis-Absorptionsmaxima

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24

Gaskell, Elizabeth Anne. "Metabolic reconstruction and validation: characterisation of two aromatic amino acid hydroxylases from Toxoplasma gondii." Thesis, University of Leeds, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493552.

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The Apicomplexa are a phylum of single celled parasitic organisms that cause a wide range of diseases from human malaria and encephalitis in AlDs patients to coccidiosis in chickens and East Coast fever in cattle. There has been a huge effort in recent years to sequence the genomes of many of these pathogens. This thesis begins by taking a comparative genomics approach to predict novel metabolic pathways from the newly sequenced genomes of Toxoplasma gondii and Eimeha tenella.

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25

Daggag, Dalia. "Computational Study on Binding of Naturally Occurring Aromatic and Cyclic Amino Acids with Graphene." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2019. http://digitalcommons.auctr.edu/cauetds/203.

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The knowledge on the conformations of amino acids is essential to understand the biochemical behaviors and physical properties of proteins. Comprehensive computational study is focused to understand the conformational landscape of three aromatic amino acids (AAAs): tryptophan, tyrosine, and phenylalanine. Three different density functionals (B3LYP, M06-2X and wB97X-D) were used with two basis sets of 6-31G(d) and 6-31+G(d,p) for geometry optimizations of the conformers of AAAs followed by the vibrational frequencies. The goal was to identify the right choice of density functional theory (DFT)

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26

Smith, Mason Scott. "Measuring the Interaction and Cooperativity Between Ionic, Aromatic, and Nonpolar Amino Acids in Protein Structure." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7443.

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Protein folding studies have provided important insights about the key role of non-covalent interactions in protein structure and conformational stability. Some of these interactions include salt bridges, cation-π, and anion-Ï€ interactions. Understanding these interactions is crucial to developing methods for predicting protein secondary, tertiary, quaternary structure from primary sequence and understanding protein-protein interactions and protein-ligand interactions. Several studies have described how the interaction between two amino acid side chains have a substantial effect on protein s

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27

Sakala, G. P. "Biophysical studies of aromatic β-amino acid tethered heterogeneous peptide oligomers and analogues of ixorapeptides". Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2013. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2185.

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28

Acworth, I. N. "Studies on the role of changes in the plasma levels of aromatic and branched-chain amino acids." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375218.

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29

Qin, Luoheng. "(I) Novel Perfluorinated Aromatic Amino Acids: Synthesis and Applications (II) Thioflavin T Dimers as Novel Amyloid Ligands." Thesis, Boston College, 2012. http://hdl.handle.net/2345/2620.

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Thesis advisor: Jianmin Gao<br>Thesis advisor: James P. Morken<br>This thesis includes two projects: "Novel perfluorinated aromatic amino acids: synthesis and applications" and "Thioflavin T dimers as novel amyloid ligands". I) Novel perfluorinated aromatic amino acids: synthesis and applications. Fluorinated amino acids serve as powerful tools in protein chemistry. Using the commercially available Boc-protected pentafluorophenylalanine, we synthesized a series of para-substituted tetrafluorophenylalanines via the regioselective SNAr reaction. These novel unnatural amino acids display useful a

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30

Roberts, Susan Ann. "Aromatic amino acid metabolism in the human, estimation of tyrosine requirement in the neonate and adult." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0003/NQ41297.pdf.

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31

Cho, Seongeun. "Modulation of tyrosine hydroxylase and aromatic L-amino acid decarboxylase by dopaminergic drugs in mouse brain /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu148786592945682.

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32

Gummalla, Sanjay. "Aromatic Amino Acid Catabolism by Lactobacillus spp.: Biochemistry and Contribution to Cheese Flavor Development." DigitalCommons@USU, 2002. https://digitalcommons.usu.edu/etd/5484.

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Amino acids derived from the degradation of casein in cheese serve as precursors for the generation of desirable and undesirable flavor compounds. Microbial degradation of aromatic amino acids is associated with the formation of aroma compounds that impart putrid-fecal, barny-utensil, and floral off-flavors in cheese, but pathways for their production had not been established. This study investigated Tyr and Phe catabolism by Lactobacillus casei and Lactobacillus helveticus cheese flavor adjuncts under simulated Cheddar cheese-ripening conditions (pH 5.2, 4% NaCl, 15°C, no sugar). Enzyme assay

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33

Silvia, Christopher Paul. "The isolation, partial peptide sequence, and cDNA sequence of aromatic L-amino acid decarboxylase from bovine adrenal medulla /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487677267729241.

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34

Young, Elizabeth A. "Second Messenger System Modulation of Aromatic L-Amino Acid Decarboxylase and Tyrosine Hydroxylase in Normal and MPTP Lesioned Mice /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487929230741091.

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35

Tran, David. "Investigating the substrate specificity of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) synthase." Thesis, University of Canterbury. Chemistry, 2011. http://hdl.handle.net/10092/6565.

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The shikimate pathway is a biosynthetic pathway that is responsible for producing a variety of organic compounds that are necessary for life in plants and microorganisms. The pathway consists of seven enzyme catalysed reactions beginning with the condensation reaction between D-erythrose 4-phosphate (E4P) and phosphoenolpyruvate (PEP) to give the seven-carbon sugar DAH7P. This thesis describes the design, synthesis and evaluation of a range of alternative non-natural four-carbon analogues of E4P (2- and 3-deoxyE4P, 3-methylE4P, phosphonate analogues of E4P) to probe the substrate specificity o

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36

Scholtka, Bettina, Dana Kühnel, Felicitas Taugner, and Pablo Steinberg. "Inflammation does not precede or accompany the induction of perneoplastic lesions in the colon of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-fed rats." Universität Potsdam, 2009. http://opus.kobv.de/ubp/volltexte/2010/4457/.

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Heterocyclic aromatic amines (HCAs) are formed in meat cooked at high temperatures for a long time or over an open flame. In this context 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant HCA in cooked meat, has been suggested to be involved in colon and prostate carcinogenesis. In the latter case it has been reported that: (1) roughly 50% of Fischer F344 male rats treated with PhIP develop carcinomas in the ventral prostate lobe at 1 year of age; (2) inflammation precedes prostatic intraepithelial neoplasia in PhIP-fed rats; (3) inflammation specifically occurs in the

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37

Tayyari, Fariba. "Efficient one-pot reductive alkylations of malononitrile with aromatic aldehydes and one-pot synthesis of new 2-amino-3-cyano-4H-chromenes." Virtual Press, 2008. http://liblink.bsu.edu/uhtbin/catkey/1399195.

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A powerful new one-pot method has been developed for the reductive alkylation of malononitrile with aromatic aldehydes. This new procedure has vastly improved the yield and efficiency and increased the scope for the aromatic aldehydes. Incorporating water as the catalyst in ethanol for the condensation step allows stoichiometric amounts of malononitrile and aldehyde to be employed. After dilution and cooling the reduction step takes place quickly and efficiently with sodium borohydride to give monosubstituted malononitriles.The product from the reductive alkylation of malononitrile with 2-quin

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38

Craig, Austin [Verfasser], and Bernd [Gutachter] Neumaier. "Preparation of Labeled Aromatic Amino Acids via Late-Stage 18F-Fluorination of Chiral Nickel and Copper Complexes / Austin Craig ; Gutachter: Bernd Neumaier." Köln : Universitäts- und Stadtbibliothek Köln, 2020. http://d-nb.info/1232404470/34.

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39

Graf, Roney. "Anthranilate synthase and chorismate mutase : allosteric regulation of two branchpoint enzymes from the aromatic amino acid biosynthetic pathway of the yeast Saccharomyces cerevisiae /." [S.l.] : [s.n.], 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10724.

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40

González, Sánchez Beatriz. "Filamentous growth in wine yeast: signal triggering and genetic factors involved." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/461060.

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Els compostos derivats d’aminoàcids aromàtics, presents de manera natural al most, són transformats pel metabolisme del llevat. En aquesta tesi, estudiem la producció d’aquests compostos en most sintètic amb diferent contingut en nutrients, per llevats del vi. Els resultats mostren que el patró de síntesi de triptofol, tirosol i fenilethanol és controlat per la disponibilitat de nutrients. A més, analitzem l’efecte d’aquests i més compostos derivats dels aminoàcids aromàtics sobre el creixement i la morfologia cel·lular del llevat. Com a resultats, observem que la filamentació induïda per etan

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41

Romagnoli, Barbara. "Synthesis and characterisation of a novel class of chiral poly(aromatic aminde) dendrimers incorporating a Câ‚ƒ-symmetric core system derived from the Î±-amino acids L- and D-serine." Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250671.

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42

Höfig, Carolin. "Establishment, validation and application of immunological and LC-MS/MS-based detection methods to study the role of human aromatic L-amino acid decarboxylase as an enzyme potentially involved in thyronamine biosynthesis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16645.

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Thyronamine (TAM) sind eine neue Molekülklasse, die endokrinologische und metabolische Prozesse miteinander vereinen. Der biologisch aktive Metabolit 3-Iod-L-Thyronamin (3-T1AM) wird durch eine kombinierte Deiodierung und Decarboxylierung von Schilddrüsenhormonen (TH) gebildet. Existierende Methoden zum Nachweis und zur Quantifizierung von 3-T1AM im menschlichen Serum sind immer noch umstritten. Auch die an der Biosynthese vermutlich beteiligte TH-Decarboxylase konnte noch nicht identifiziert werden. Für die Identifizierung und Quantifizierung von TH und TAM Profilen wurde die Flüssigchromatog

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43

Moraes, Carolina Pucci de. "Efeitos de doses subletais de glyphosate no crescimento, consumo de água e absorção de nutrientes em Urochloa decumbens /." Botucatu, 2019. http://hdl.handle.net/11449/191392.

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Orientador: Edivaldo Domingues Velini<br>Resumo: A espécie Urochloa decumbens é uma das plantas mais importantes e frequentes em áreas com culturas perenes e em áreas não-agrícolas. Os efeitos secundários que ocorrem nas plantas pela aplicação de baixas doses de glyphosate ainda são pouco compreendidos. Desse modo, a hipótese dessa pesquisa foi de que as baixas doses de glyphosate podem suprimir o crescimento, reduzir a competição e permitir a sua utilização para manutenção da cobertura vegetal. Assim, o objetivo do trabalho foi avaliar os efeitos de doses subletais de glyphosate no cresciment

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44

Fournel, Jean-Louis. "Synthèse et étude de nouveaux agonistes dopaminergiques : les amino hydroxy tetrahydro quinoléines." Rouen, 1986. http://www.theses.fr/1986ROUES029.

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Synthèse d'hydroxy- ou dihydroxy amino-3 tetrahydro-1,2,3,4 quinoléines par réduction par NABH4 ou par hydrogénations sur palladium d'amino-3 quinoléines ; études de relation structure activité ; calculs MNDO et CNDO

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45

Miller, Danielle Virginia. "Methanocaldococcus jannaschii and the Recycling of S-adenosyl-L-methionine." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/77520.

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S-Adenosyl-L-methionine (SAM) is an essential metabolite for all domains of life. SAM- dependent reactions result in three major metabolites: S-adenosyl-L-homocysteine (SAH), methylthioadenosine (MTA), and 5'-deoxyadenosine (5'-dA). Each of these has been demonstrated to be feedback inhibitors of SAM dependent enzymes. Thus, each metabolite has a pathway to prevent inhibition through the salvage of nucleoside and ribose moieties. However, these salvage pathways are not universally conserved. In the anaerobic archaeal organism Methanocaldococcus jannaschii, the salvage of SAH, MTA, and 5'-dA,

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46

Er-Rhaimini, Abderrahman. "Hétérocycles azotes N-benziles : synthèse de dérivés N-benziles de l'adénine : étude de la photoélimination de substituants benzyliques." Angers, 1986. http://www.theses.fr/1986ANGE0002.

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Synthèse des cinq N-(dimethoxy-3,5 benzyl) adénines. Photolyse de ces compose en solution aqueuse. Tentative de synthèse de l'(imidazo (1,2-a) pyridinyl-6methyl)-1 adénine. Ce travail montre que des substituants benzyliques photoéliminables peuvent être utilisés comme groupes protecteurs dans des synthèses mettant en jeu l'adénine et ses dérivés.

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47

Höfig, Carolin [Verfasser], Werner [Akademischer Betreuer] Kloas, Josef [Akademischer Betreuer] Köhrle, and Dagmar [Akademischer Betreuer] Führer-Sakel. "Establishment, validation and application of immunological and LC-MS/MS-based detection methods to study the role of human aromatic L-amino acid decarboxylase as an enzyme potentially involved in thyronamine biosynthesis / Carolin Höfig. Gutachter: Werner Kloas ; Josef Köhrle ; Dagmar Führer-Sakel." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://d-nb.info/1029763844/34.

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48

Peartree, Philip Neil Alexander. "Simulation studies of aromatic amine dehydrogenase bound phenylethylamine analogues." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/simulation-studies-of-aromatic-amine-dehydrogenase-bound-phenylethylamine-analogues(5ea2720e-b66a-4287-b2b8-eb4793a966d7).html.

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Abstract:

A series of para-substituted phenylethylamine analogues bound to the enzyme aromatic amine dehydrogenase have been simulated using quantum mechanical electronic structure calculations and molecular mechanical molecular dynamics simulations. Trends have been verified connecting bond dissociation energy (and thus driving force) to observed rate constants and activation enthalpy. Trends have been identified in connecting statistics drawn from molecular dynamics simulations and the temperature dependence of the kinetic isotope effect, notably that as the temperature dependence of the kinetic isoto

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49

Pigeon, Dominique. "Etude des enzymes de synthèse des catécholamines et phosphorylation de la tyrosine hydroxylase de phéochromocytome de rat." Paris 6, 1986. http://www.theses.fr/1986PA066168.

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La structure et le régulation des enzymes de synthèse des catécholamines ont été étudiées dans le phéochromocytome de rat. Nous avons mis au point un protocole permettant la séparation des trois premiers enzymes de la voie de synthèse. Ceci a permis de purifier partiellement la dopamine beta -hydroxylase et de mettre en évidence son inhibiteur endogène, qui a été décrit pour la première fois. Nous avons montré qu'une activité protéine kinase était copurifiée avec la tyrosine hydroxylase, qu'elle phosphoryle. Cette activité a été caractérisé et la séquence primaire du site de phosphorylation a

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50

Gebre-Medhin, Gennet. "Clinical and experimental studies of organ-specific autoimmune diseases : With special reference to Addison's disease and autoimmune hepatitis : by Gennet Gebre-Medhin." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5043-1/.

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