Relevant bibliographies by topics / Aromatic Nucleophilic Substitution (SNAr)

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Aromatic Nucleophilic Substitution (SNAr)'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 May 2024

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Journal articles on the topic "Aromatic Nucleophilic Substitution (SNAr)"

1

Li, Jinhua, Zhengyu Lu, Yuhui Hua, Dafa Chen, and Haiping Xia. "Carbolong chemistry: nucleophilic aromatic substitution of a triflate functionalized iridapentalene." Chemical Communications 57, no. 68 (2021): 8464–67. http://dx.doi.org/10.1039/d1cc03261e.

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Vasilenko, Dmitry A., Sevastian E. Dronov, Dzianis U. Parfiryeu, et al. "5-Nitroisoxazoles in SNAr reactions: access to polysubstituted isoxazole derivatives." Organic & Biomolecular Chemistry 19, no. 29 (2021): 6447–54. http://dx.doi.org/10.1039/d1ob00816a.

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An efficient protocol for the straightforward functionalization of the isoxazole ring via the reactions of aromatic nucleophilic substitution of the nitro group with various nucleophiles has been elaborated.
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Kikushima, Kotaro, Haruka Koyama, Kazuki Kodama, and Toshifumi Dohi. "Nucleophilic Aromatic Substitution of Polyfluoroarene to Access Highly Functionalized 10-Phenylphenothiazine Derivatives." Molecules 26, no. 5 (2021): 1365. http://dx.doi.org/10.3390/molecules26051365.

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Nucleophilic aromatic substitution (SNAr) reactions can provide metal-free access to synthesize monosubstituted aromatic compounds. We developed efficient SNAr conditions for p-selective substitution of polyfluoroarenes with phenothiazine in the presence of a mild base to afford the corresponding 10-phenylphenothiazine (PTH) derivatives. The resulting polyfluoroarene-bearing PTH derivatives were subjected to a second SNAr reaction to generate highly functionalized PTH derivatives with potential applicability as photocatalysts for the reduction of carbon–halogen bonds.
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Zhang, Xiao, Guo-ping Lu, and Chun Cai. "Facile aromatic nucleophilic substitution (SNAr) reactions in ionic liquids: an electrophile–nucleophile dual activation by [Omim]Br for the reaction." Green Chemistry 18, no. 20 (2016): 5580–85. http://dx.doi.org/10.1039/c6gc01742h.

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Liljenberg, Magnus, Tore Brinck, Tobias Rein та Mats Svensson. "Utilizing the σ-complex stability for quantifying reactivity in nucleophilic substitution of aromatic fluorides". Beilstein Journal of Organic Chemistry 9 (23 квітня 2013): 791–99. http://dx.doi.org/10.3762/bjoc.9.90.

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A computational approach using density functional theory to compute the energies of the possible σ-complex reaction intermediates, the “σ-complex approach”, has been shown to be very useful in predicting regioselectivity, in electrophilic as well as nucleophilic aromatic substitution. In this article we give a short overview of the background for these investigations and the general requirements for predictive reactivity models for the pharmaceutical industry. We also present new results regarding the reaction rates and regioselectivities in nucleophilic substitution of fluorinated aromatics.
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Walton, James W., and Jonathan M. J. Williams. "Catalytic SNAr of unactivated aryl chlorides." Chemical Communications 51, no. 14 (2015): 2786–89. http://dx.doi.org/10.1039/c4cc07116f.

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Hudson, R., N. P. Bizier, K. N. Esdale, and J. L. Katz. "Synthesis of indoles, benzofurans, and related heterocycles via an acetylene-activated SNAr/intramolecular cyclization cascade sequence in water or DMSO." Organic & Biomolecular Chemistry 13, no. 8 (2015): 2273–84. http://dx.doi.org/10.1039/c4ob02549k.

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The synthesis of 2-substituted indoles and benzofurans was achieved by nucleophilic aromatic substitution, followed by subsequent 5-endo-dig cyclization between the nucleophile and an ortho acetylene.
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8

Xu, Hui, and Hong-Feng Li. "One-pot Microwave-assisted Tandem Deprotection of Arylmethanesulfonates / SNAr Reaction for K2CO3-mediated C(Aryl)–O Bond Formation." Zeitschrift für Naturforschung B 62, no. 9 (2007): 1183–86. http://dx.doi.org/10.1515/znb-2007-0912.

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One-pot microwave-assisted tandem deprotection of arylmethanesulfonates / nucleophilic aromatic substitution reaction (SNAr) with activated aryl halides to synthesize asymmetrical diaryl ethers is described.
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9

Abd-El-Aziz, Alaa S., Christine R. de Denus, and Harold M. Hutton. "Ironcyclopentadienyl mediated 2-alkyl-2-arylphenylsulphonylacetonitrile synthesis." Canadian Journal of Chemistry 73, no. 2 (1995): 289–95. http://dx.doi.org/10.1139/v95-039.

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A unique route to the synthesis of 2-alkyl-2-arylphenylsulphonylacetonitriles via the nucleophilic aromatic substitution (SNAr) of chloroarene cyclopentadienyliron complexes with 2-alkyl phenylsulphonylacetonitriles has been investigated. Reactions of chloroarene complexes (1a–d) with 2-alkyl phenylsulphonylacetonitrile (2a,b) in the presence of K2CO3 in DMF at room temperature led to the formation of complexes 3a–d and 4a,c,d in good yields. The use of alkylated phenylsulphonylacetonitriles as nucleophiles in the reactions with the p-dichlorobenzene complex (1e) allowed the formation of the d
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10

Zhang, Xiao, Guo-ping Lu, and Chun Cai. "Correction: Facile aromatic nucleophilic substitution (SNAr) reactions in ionic liquids: an electrophile–nucleophile dual activation by [Omim]Br for the reaction." Green Chemistry 18, no. 22 (2016): 6143. http://dx.doi.org/10.1039/c6gc90108e.

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Correction for ‘Facile aromatic nucleophilic substitution (S<sub>N</sub>Ar) reactions in ionic liquids: an electrophile–nucleophile dual activation by [Omim]Br for the reaction’ by Xiao Zhang, et al., Green Chem., 2016, 18, 5580–5585.
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Dissertations / Theses on the topic "Aromatic Nucleophilic Substitution (SNAr)"

1

Donham, Leah L. "Gas-Phase Studies of Nucleophilic Substitution Reactions: Halogenating and Dehalogenating Aromatic Heterocycles." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5645.

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Halogenated heterocycles are common in pharmaceutical and natural products and there is a need to develop a better understanding of processes used to synthesize them. Although the halogenation of simple aromatic molecules is well understood, the mechanisms behind the halogenation of aromatic heterocycles have been more problematic to elucidate because multiple pathways are possible. Recently, new, radical-based mechanisms have been proposed for heterocycle halogenation. In this study, we examine and test the viability of possible nucleophilic substitution, SN2@X, mechanisms in the halogenat
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Liu, Jiangqiong. "Kinetic Studies of 6-Halopurine Nucleoside in SNAr Reactions; 6-(Azolyl, Alkylthio and Fluoro)-purine Nucleosides as Substrates for Suzuki Reactions." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1821.pdf.

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Pescheteau, Clémentine. "Conception et synthèse d’inhibiteurs duaux de DYRK1A et CLK1, kinases impliquées dans la maladie d’Alzheimer." Electronic Thesis or Diss., Orléans, 2021. http://www.theses.fr/2021ORLE3203.

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La maladie d’Alzheimer est la forme de démence la plus répandue dans le monde et à ce jour, aucun traitement efficace n’existe malgré de nombreuses recherches en cours. De nouvelles stratégies thérapeutiques ont émergé, ciblant des protéines kinases impliquées dans les processus de neurodégénération et de neuroinflammation. DYRK1A et CLK1 ont notamment été identifiées comme des cibles intéressantes pour lutter contre des pathologies du système nerveux central, et sont particulièrement impliquées dans la maladie d’Alzheimer. Afin de concevoir des inhibiteurs puissants et sélectifs de ces deux k
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4

Chen, Zhongrui. "Azacalixphyrines : émergence d'une nouvelle famille de tétraazamacrocycles aromatiques." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4074.

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Les travaux de thèse présentés dans ce mémoire ont ciblé trois familles de molécules π-conjuguées et s’inscrivent plus particulièrement dans le développement de la chimie des amino-azacalixarènes et des dérivés de phénazine, et d’une nouvelle classe de tétraazamacrocycles aromatiques appelés « azacalixphyrine ». Ces composés étant émergents dans la littérature, nous avons volontairement porté nos efforts sur la synthèse et la compréhension de ces nouveaux systèmes π-conjugués afin d’élaborer de nouvelles voies de synthèse mais aussi, le cas échéant, d’établir des relations structure / propriét
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Le, Tin Thanh. "Métallation et substitution nucléophile aromatique des acides benzoïques non protégés : application à la synthèse totale de l’apogossypol." Thesis, Le Mans, 2011. http://www.theses.fr/2011LEMA1016/document.

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Dans le cadre d’un projet général concernant l’étude de la réactivité des acidesbenzoïques non protégés avec les organométalliques, la synthèse totale d’analoguesstructuraux de l’apogossypol mettant en jeu des réactions de métallation aromatique a étéétudiée ainsi que la réaction de substitution nucléophile aromatique des acides benzoïquesortho-fluorés et ortho-méthoxylés.Le gossypol, (1,1’,6,6’,7,7’-hexahydroxy-5,5’-di-iso-propyl-3,3’-diméthyl-2,2’-binaphtalène-8,8’-dicarboxaldéhyde), pigment principal des graines du cotonnier, existe sousla forme de deux atropoisomères et possède de multiple
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Chen, Zhongrui. "Azacalixphyrines : émergence d'une nouvelle famille de tétraazamacrocycles aromatiques." Electronic Thesis or Diss., Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4074.

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Les travaux de thèse présentés dans ce mémoire ont ciblé trois familles de molécules π-conjuguées et s’inscrivent plus particulièrement dans le développement de la chimie des amino-azacalixarènes et des dérivés de phénazine, et d’une nouvelle classe de tétraazamacrocycles aromatiques appelés « azacalixphyrine ». Ces composés étant émergents dans la littérature, nous avons volontairement porté nos efforts sur la synthèse et la compréhension de ces nouveaux systèmes π-conjugués afin d’élaborer de nouvelles voies de synthèse mais aussi, le cas échéant, d’établir des relations structure / propriét
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Kennedy, R. J. "Copper-promoted nucleophilic aromatic substitution." Thesis, University of Kent, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355148.

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Clough, Robert Steven. "The synthesis of aromatic polyethers by aromatic nucleophilic substitution." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1057072167.

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Jones, Craig Warren. "Nucleophilic aromatic substitution using supported copper(I) reagents." Thesis, University of York, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236184.

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Martin, Peter Arnold. "Nucleophilic substitution reactions of some polyhalogenated compounds." Thesis, Durham University, 1987. http://etheses.dur.ac.uk/6876/.

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Rate measurements for the reactions of a series of polyfluoro - and polychloro - pyridines with aniline and ammonia in 60/40 dioxan/water at 25ºC has shown that chlorine, when ortho and para to the position of attack, is activating with respect to fluorine, but at the position meta to the point of attack, chlorine and fluorine are virtually equivalent in their effect on reaction rate. The trifluoromethyl and nitrile groups were found to be activating relative to fluorine when ortho and para to the position of substitution and the nitrile group was thus found to be ortho/para directing. The ort
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Books on the topic "Aromatic Nucleophilic Substitution (SNAr)"

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Terrier, François. Modern Nucleophilic Aromatic Substitution. Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527656141.

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N, Charushin Valery, and Plas, H. C. van der., eds. Nucleophilic aromatic substitution of hydrogen. Academic Press, 1994.

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Nucleophilic aromatic displacement: The influence of the nitro group. VCH Publishers, 1991.

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Burgers, Martijn Hendrik Willem. Zeolite-catalyzed nucleophilic aromatic substitution reactions =: Nucleofiele aromatische substitutie-reakties gekatalyseerd door metaalhoudende zeolieten. Delft University Press, 1995.

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Burgers, Martijn Hendrik Willem. Zeolite-catalyzed nucleophilic aromatic substitution reactions =: Nucleofiele aromatische substitutie-reakties gekatalyseerd door metaalhoudende zeolieten. Delft University Press, 1995.

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6

Hardee, David James. Part 1 : Lanthanum Triflate-Catalyzed Cyclopropanation via Intramolecular Methylene Transfer. Part 2: Reaction Design with Aromatic Ions - Nucleophilic Acyl Substitution and Organophotoredox Catalysts. [publisher not identified], 2011.

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Terrier, Francois. Modern Nucleophilic Aromatic Substitution. Wiley & Sons, Limited, John, 2013.

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Terrier, Francois. Modern Nucleophilic Aromatic Substitution. Wiley & Sons, Incorporated, John, 2013.

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Modern Nucleophilic Aromatic Substitution. Wiley-VCH Verlag GmbH, 2013.

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Terrier, Francois. Modern Nucleophilic Aromatic Substitution. Wiley & Sons, Incorporated, John, 2013.

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Book chapters on the topic "Aromatic Nucleophilic Substitution (SNAr)"

1

Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470975800.ch5.

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Norman, Richard, and James M. Coxon. "Nucleophilic aromatic substitution." In Principles of Organic Synthesis. Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-2166-8_12.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms · 2008. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470979525.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119972471.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118560273.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms 2001. John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/0470866748.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781119941910.ch5.

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Crampton, Michael R. "Nucleophilic Aromatic Substitution." In Arene Chemistry. John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781118754887.ch6.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/0470022051.ch5.

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Caron, Stéphane, and Arun Ghosh. "Nucleophilic Aromatic Substitution." In Practical Synthetic Organic Chemistry. John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118093559.ch4.

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Conference papers on the topic "Aromatic Nucleophilic Substitution (SNAr)"

1

VO-THANH, Giang, and Alain PETIT. "Solvent-Free Microwaves Assisted Amination of Haloarenes by Aromatic Nucleophilic Substitution." In The 15th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2011. http://dx.doi.org/10.3390/ecsoc-15-00763.

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