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Journal articles on the topic 'Arrhythmia'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Epifanio, Hindalis Ballesteros, Marcelo Katz, Melania Aparecida Borges, et al. "The use of external event monitoring (web-loop) in the elucidation of symptoms associated with arrhythmias in a general population." Einstein (São Paulo) 12, no. 3 (2014): 295–99. http://dx.doi.org/10.1590/s1679-45082014ao2939.

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Objective To correlate arrhythmic symptoms with the presence of significant arrhythmias through the external event monitoring (web-loop). Methods Between January and December 2011, the web-loop was connected to 112 patients (46% of them were women, mean age 52±21 years old). Specific arrhythmic symptoms were defined as palpitations, pre-syncope and syncope observed during the monitoring. Supraventricular tachycardia, atrial flutter or fibrillation, ventricular tachycardia, pauses greater than 2 seconds or advanced atrioventricular block were classified as significant arrhythmia. The associatio

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Sridhar, Anuradha, Alessandro Giamberti, Sara Foresti, et al. "Fontan conversion with concomitant arrhythmia surgery for the failing atriopulmonary connections: mid-term results from a single centre." Cardiology in the Young 21, no. 6 (2011): 665–69. http://dx.doi.org/10.1017/s1047951111000643.

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AbstractObjectivesClassical Atriopulmonary Fontan connections tend to fail in the long term due to progressive anastomotic site obstruction, right atrial enlargement, and refractory atrial arrhythmias. Conversion to total cavopulmonary connection with concomitant arrhythmia surgery is a promising treatment but optimal timing of the procedure remains controversial.MethodsBetween the years 2002 and 2009, 15 patients with a median age of 26.2 (12–43) years underwent Fontan conversion operation with concomitant arrhythmia surgery. All were symptomatic and 14 out of the 15 patients had refractory a

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Akhmedov, V. A., M. A. Livzan, and O. V. Gaus. "COVID-19 and arrhythmias - is there a relationship?" South Russian Journal of Therapeutic Practice 3, no. 3 (2022): 17–24. http://dx.doi.org/10.21886/2712-8156-2022-3-3-17-24.

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COVID-19 infection is associated with many different systemic complications. Among these, cardiovascular system complications are particularly important as these are associated with significant mortality. There are many different subgroups of cardiovascular complications, with arrhythmias being one of them. Arrhythmias are especially important as there are a substantial percentage of patients who have arrhythmia after a COVID-19 infection, and these patients are seen with an increased mortality rate. Arrhythmias in COVID-19 patients are associated with inflammation, electrolyte abnormalities,

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Shashank, Shekhar Mishra, Kumar Neeraj, Sirvi Gajaram, Shekhar Sharma Chandra, Pratap Singh Hamendra, and Pandiya Harshda. "Computational Prediction of Pharmacokinetic, Bioactivity and Toxicity Parameters of Some Selected Anti arrhythmic Agents." Pharmaceutical and Chemical Journal 4, no. 5 (2017): 143–46. https://doi.org/10.5281/zenodo.13853911.

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Many pharmacological agents are available for the treatment of cardiac arrhythmias. Arrhythmia may be classified on the basis of rate (bradycardia and tachycardia), mechanism (automaticity, re-entry, triggered) or duration (isolated premature beats; couplets). The treatment approach to arrhythmia depends firstly on whether or not the affected person is stable or unstable. This research investigation finds the various pharmacokinetic, bioactivity and toxicity parameters for some selected anti-arrhythmic agents for designing new agents.  

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Ertugay, Serkan, Zehra Ünlü, Sedat Karaca, Yaprak Engin, Evrim Şimşek, and Mustafa Özbaran. "[MSB-11] Arrhythmia Course After Surgical Treatment of Mitral Annular Disjunction." Turkish Journal of Thoracic and Cardiovascular Surgery 32, no. 4 (2024): 28–29. https://doi.org/10.5606/tgkdc.dergisi.2024.msb-11.

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Objective: This study aimed to investigate the course of arrhythmia in patients with mitral annular disjunction (MAD) based on 24-h Holter electrocardiogram. Methods: In this retrospective study, 140 patients who underwent mitral valve surgery for type 2 dysfunction between ?? 2017 and May 2024 were reviewed. Forty-five patients with MAD were identified. A history of arrhythmia was identified in 30 (18 females, 12 males; mean age: 38.5±13.76 years) of these 45 patients. Results: The mean cardiopulmonary bypass time was 134.2 min, and the mean cross-clamp time was 99.1 min. One patient died due

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Ertugay, Serkan, Zehra Ünlü, Sedat Karaca, Yaprak Engin, Evrim Şimşek, and Mustafa Özbaran. "[MSB-11] Arrhythmia Course After Surgical Treatment of Mitral Annular Disjunction." Cardiovascular Surgery and Interventions 11, no. 100 (2024): 17. https://doi.org/10.5606/e-cvsi.2024.msb-11.

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Objective: This study aimed to investigate the course of arrhythmia in patients with mitral annular disjunction (MAD) based on 24-h Holter electrocardiogram. Methods: In this retrospective study, 140 patients who underwent mitral valve surgery for type 2 dysfunction between ?? 2017 and May 2024 were reviewed. Forty-five patients with MAD were identified. A history of arrhythmia was identified in 30 (18 females, 12 males; mean age: 38.5±13.76 years) of these 45 patients. Results: The mean cardiopulmonary bypass time was 134.2 min, and the mean cross-clamp time was 99.1 min. One patient died due

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Gasperetti, Alessio, Cynthia A. James, Liang Chen, et al. "Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy—A Multicenter Study." Journal of Clinical Medicine 10, no. 21 (2021): 4962. http://dx.doi.org/10.3390/jcm10214962.

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Background: Atrial arrhythmias are present in up to 20% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Catheter ablation (CA) is an effective treatment for atrial arrhythmias in the general population. Data regarding CA for atrial arrhythmias in ARVC are scarce. Objective: To assess the safety and efficacy of CA for atrial arrhythmias in patients with ARVC. Methods: In this international collaborative effort, all patients with a definite diagnosis of ARVC undergoing CA for atrial fibrillation (AF), focal atrial tachycardia (AT), or cavotricuspid isthmus (CTI)-dependen

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Poeppel, T. D., M. Reinhardt, E. G. Vester, et al. "Myocardial perfusion/metabolism mismatch and ventricular arrhythmias in the chronic post infarction state." Nuklearmedizin 44, no. 03 (2005): 69–75. http://dx.doi.org/10.1055/s-0038-1625688.

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Summary Aim: Ventricular arrhythmias have been shown to originate in the myocardial peri-infarct region due to irregular heterotopic conduction. Hypoperfused but viable myocardium is often localised in those areas and may be involved in the pathogenesis of arrhythmias. We tested the hypothesis that these myocardial perfusion/metabolism mismatches (MM) are significantly associated with ventricular arrhythmias in the chronic post infarction state. Patients, methods: 47 post infarction patients were included in the study. 33 suffered from ventricular arrhythmia whereas 14 did not. All patients un

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CHIU, CHUANG-CHIEN, TONG-HONG LIN, and BEN-YI LIAU. "USING CORRELATION COEFFICIENT IN ECG WAVEFORM FOR ARRHYTHMIA DETECTION." Biomedical Engineering: Applications, Basis and Communications 17, no. 03 (2005): 147–52. http://dx.doi.org/10.4015/s1016237205000238.

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Arrhythmia is one kind of diseases that gives rise to the death and possibly forms the immedicable danger. The most common cardiac arrhythmia is the ventricular premature beat. The main purpose of this study is to develop an efficient arrhythmia detection algorithm based on the morphology characteristics of arrhythmias using correlation coefficient in ECG signal. Subjects for experiments included normal subjects, patients with atrial premature contraction (APC), and patients with ventricular premature contraction (PVC). So and Chan's algorithm was used to find the locations of QRS complexes. W

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van Bavel, Joanne J. A., Henriëtte D. M. Beekman, Agnieszka Smoczyńska, Marcel A. G. van der Heyden, and Marc A. Vos. "IKs Activator ML277 Mildly Affects Repolarization and Arrhythmic Outcome in the CAVB Dog Model." Biomedicines 11, no. 4 (2023): 1147. http://dx.doi.org/10.3390/biomedicines11041147.

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Long QT syndrome type 1 with affected IKs is associated with a high risk for developing Torsade de Pointes (TdP) arrhythmias and eventually sudden cardiac death. Therefore, it is of high interest to explore drugs that target IKs as antiarrhythmics. We examined the antiarrhythmic effect of IKs channel activator ML277 in the chronic atrioventricular block (CAVB) dog model. TdP arrhythmia sensitivity was tested in anesthetized mongrel dogs (n = 7) with CAVB in series: (1) induction experiment at 4 ± 2 weeks CAVB: TdP arrhythmias were induced with our standardized protocol using dofetilide (0.025

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Baghel, Anita, Manoj Kumar, J. P. Soni, Mudit Agarwal, and Ravi Kumar. "Experience with Holter monitoring for evaluation of infant arrhythmia." International Journal of Contemporary Pediatrics 6, no. 3 (2019): 1362. http://dx.doi.org/10.18203/2349-3291.ijcp20192044.

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Background: Arrhythmia is defined as abnormal heart rates. Sometimes they are intermittent and difficult to diagnose on routine ECG. Neonatologist and Pediatrician needs to rapidly establish accurate diagnosis and management for infants suspected to have arrhythmia. Hence Holter monitoring of the infants presenting with symptoms suggestive of arrhythmia is necessary as it provides a continuous record of heart’s electrical activity. The aim of this paper is to find out the role of continuous ambulatory electrocardiographic monitoring in daily clinical practice of Pediatrics.Methods: All infants

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Gauvrit, Sébastien, Jaclyn Bossaer, Joyce Lee, and Michelle M. Collins. "Modeling Human Cardiac Arrhythmias: Insights from Zebrafish." Journal of Cardiovascular Development and Disease 9, no. 1 (2022): 13. http://dx.doi.org/10.3390/jcdd9010013.

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Cardiac arrhythmia, or irregular heart rhythm, is associated with morbidity and mortality and is described as one of the most important future public health challenges. Therefore, developing new models of cardiac arrhythmia is critical for understanding disease mechanisms, determining genetic underpinnings, and developing new therapeutic strategies. In the last few decades, the zebrafish has emerged as an attractive model to reproduce in vivo human cardiac pathologies, including arrhythmias. Here, we highlight the contribution of zebrafish to the field and discuss the available cardiac arrhyth

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Li, Jie, Bin Li, Hailiang Huang, Tao Han, and Yang Li. "Allocryptopine: A Review of Its Properties and Mechanism of Antiarrhythmic Effect." Current Protein & Peptide Science 20, no. 10 (2019): 996–1003. http://dx.doi.org/10.2174/1389203720666190807123609.

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Abstract：Throughout the last decade, extensive efforts have been devoted to developing a percutaneous catheter ablation and implantable cardioverter-defibrillator technique for patients suffering from ventricular arrhythmia. Antiarrhythmic drug efficacy for preventing arrhythmias remains disappointing because of adverse cardiovascular effects. Allocryptopine is an isoquinoline alkaloid widely present in medicinal herbs. Studies have indicated that allocryptopine exhibits potential anti-arrhythmic actions in various animal models. The potential therapeutic benefit of allocryptopine in arrhythmi

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Drakopoulou, Maria, Heba Nashat, Aleksander Kempny, et al. "Arrhythmias in adult patients with congenital heart disease and pulmonary arterial hypertension." Heart 104, no. 23 (2018): 1963–69. http://dx.doi.org/10.1136/heartjnl-2017-312881.

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ObjectivesApproximately 5%–10% of adults with congenital heart disease (CHD) develop pulmonary arterial hypertension (PAH), which affects life expectancy and quality of life. Arrhythmias are common among these patients, but their incidence and impact on outcome remains uncertain.MethodsAll adult patients with PAH associated with CHD (PAH-CHD) seen in a tertiary centre between 2007 and 2015 were followed for new-onset atrial or ventricular arrhythmia. Clinical variables associated with arrhythmia and their relation to mortality were assessed using Cox analysis.ResultsA total of 310 patients (me

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Hong, Bihong, Jianlin He, Qingqing Le, Kaikai Bai, Yongqiang Chen, and Wenwen Huang. "Combination Formulation of Tetrodotoxin and Lidocaine as a Potential Therapy for Severe Arrhythmias." Marine Drugs 17, no. 12 (2019): 685. http://dx.doi.org/10.3390/md17120685.

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Severe arrhythmias—such as ventricular arrhythmias—can be fatal, but treatment options are limited. The effects of a combined formulation of tetrodotoxin (TTX) and lidocaine (LID) on severe arrhythmias were studied. Patch clamp recording data showed that the combination of LID and TTX had a stronger inhibitory effect on voltage-gated sodium channel 1.5 (Nav1.5) than that of either TTX or LID alone. LID + TTX formulations were prepared with optimal stability containing 1 μg of TTX, 5 mg of LID, 6 mg of mannitol, and 4 mg of dextran-40 and then freeze dried. This formulation significantly delaye

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Thiruganasambandamoorthy, V., M. Sivilotti, M. A. Mukarram, et al. "LO98: Optimal length of observation for emergency department patients with syncope: a time to event analysis." CJEM 19, S1 (2017): S62. http://dx.doi.org/10.1017/cem.2017.160.

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Introduction: Concern for occult serious conditions leads to variations in ED syncope management [hospitalization, duration of ED/inpatient monitoring including Syncope Observation Units (SOU) for prolonged monitoring]. We sought to develop evidence-based recommendations for duration of ED/post-ED ECG monitoring using the Canadian Syncope Risk Score (CSRS) by assessing the time to serious adverse event (SAE) occurrence. Methods: We enrolled adults with syncope at 6 EDs and collected demographics, time of syncope and ED arrival, CSRS predictors and time of SAE. We stratified patients as per the

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Rezwan, Refaya, Sharmin Zafar, Abu Asad Chowdhury, Shaila Kabir, Mohammad Shah Amran, and Mohammad Abdur Rashid. "Studies of Anti-arrhythmic and Hypercholesterolemic Activities of Ayurvedic Preparation Lauhasab in Rat Model." Dhaka University Journal of Pharmaceutical Sciences 16, no. 1 (2017): 95–105. http://dx.doi.org/10.3329/dujps.v16i1.33387.

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Lauhasab, an Ayurvedic preparation, is widely used in anemia and cardiovascular diseases. Despite its claim as a cardio-tonic there is paucity of studies on pharmacological activities and toxicities. In this study, the anti-arrhythmic effect and impact on lipid profile were evaluated. Rats were pretreated with 0.28 and 2.8 ml/kg body weight of Lauhasab for 35 days and electrocardiographic tracings were recorded and analyzed to determine heart rate and occurrence of arrhythmia. Electrocardiogram recorded before digoxin administration showed significant decrease in mean heart rate along with lon

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Eftekhari, Helen. "Pharmacotherapy in arrhythmias: an overview of anti-arrhythmic drug therapy." British Journal of Cardiac Nursing 16, no. 4 (2021): 1–9. http://dx.doi.org/10.12968/bjca.2021.0044.

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The article provides an overview of the principles in anti-arrhythmic drug prescribing. The cardiac action potential is explained, followed by general principles involved in treating arrhythmias and prescribing decisions. An overview of the five classifications of anti-arrhythmic drugs is given, with examples of the main drugs in the classification and principles to consider within each. Finally, anticoagulation is reviewed, being a cornerstone prescribing decision-making in the most common arrhythmia, atrial fibrillation.

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Bommer, Thea, Maria Knierim, Julia Unsöld, et al. "Simulation of cardiac arrhythmias in human induced pluripotent stem cell-derived cardiomyocytes." PLOS ONE 19, no. 9 (2024): e0310463. http://dx.doi.org/10.1371/journal.pone.0310463.

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The effects and mechanisms of cardiac arrhythmias are still incompletely understood and an important subject of cardiovascular research. A major difficulty for investigating arrhythmias is the lack of appropriate human models. Here, we present a protocol for a translational simulation of different types of arrhythmias using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and electric cell culture pacing. The protocol comprises the handling of ventricular and atrial hiPSC-CM before and during in vitro arrhythmia simulation and possible arrhythmia simulation protocols mimic

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Wang, Yan, Pei Tao, and Yu-Jie Wang. "Attenuated Structural Transformation of Indaconitine during Sand Frying Process and Anti-Arrhythmic Effects of Its Transformed Products." Evidence-Based Complementary and Alternative Medicine 2022 (February 17, 2022): 1–12. http://dx.doi.org/10.1155/2022/8606459.

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The transformation pathways of diterpenoid alkaloids have been clarified clearly in the boiling and steaming process, but remain to be determined in the sand frying process. The aims of the study were to investigate the transformation pathways of indaconitine in the sand frying process, as well as examine the cardiotoxicity and anti-arrhythmic activity of indaconitine and its transformed products. The transformed product was separated by column chromatography, and the structure was identified by 1H NMR, 13C NMR, and HR-ESI-MS. The cardiotoxicity of indaconitine and its transformed products was

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Rasheed, A., M. D. Khan, A. K. Duke, et al. "Abstracts for the British Congenital Cardiac Association Annual Meeting: The Barbican, London, 24–25 November 2005: Poster Presentations: ECMO support for lifethreatening arrhythmia in infancy permits successful radiofrequency treatment." Cardiology in the Young 16, no. 3 (2006): 318–19. http://dx.doi.org/10.1017/s1047951106270239.

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The majority of arrhythmias presenting in infancy cardiovert readily or rapidly respond to conventional medical therapy. A small number prove highly refractory to anti-arrhythmic medications. Myocardial performance may be severely compromised by the combination of fast heart rate and negatively inotropic drugs. Some babies die. We have recently supported 2 babies with refractory arrhythmias on ECMO, both to pursue drug therapy and eventually, to support the circulation during radiofrequency ablation, with very successful results. The first patient was a 2.5 kg neonate presenting with collapse

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Deanfield, John E., Seamus Cullen, and Marc Gewillig. "Arrhythmias after surgery for complete transposition: Do they matter?" Cardiology in the Young 1, no. 1 (1991): 91–96. http://dx.doi.org/10.1017/s1047951100000147.

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SummaryConcern about long-term complications after intraatrial repair of complete transposition has been used as an argument in favor of “anatomic” repair by the arterial switch operation. Late arrhythmias, including loss of sinus rhythm and the development of supraventricular tachycardias, particularly atrial flutter, are widely reported after intraatrial repair. Despite modifications of technique, the electrophysiologic substrate for arrhythmia results from the extensive atrial surgery required. Arrhythmias occur, even in the “modern surgical era” after both Mustard and Senning operations, a

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Kristanto, Harris, Budi Satrijo, Sasmojo Widito, and Ardian Rizal. "Reperfusion Arrhythmia in Acute Myocardial Infarction: Clinical Implication and Management." Heart Science Journal 3, no. 1 (2022): 4–14. http://dx.doi.org/10.21776/ub.hsj.2022.003.01.2.

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Reperfusion is a critical component of myocardium survival in acute myocardial infarction to minimize infarct size and improve clinical prognosis. Reperfusion, on the other hand, may result in increased and accelerated myocardial injury, a condition known as reperfusion injury. Following reperfusion, several arrhythmias are observed, and it is called reperfusion arrhythmia. Reperfusion arrhythmia is one manifestation of reperfusion injury. Numerous modest studies have evaluated what reperfusion arrhythmias are defined. It is described as an arrhythmia that occurs immediately or within the firs

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Manohar, Udutha, G. Rangha Vardhan, Mohammad Shireen, and T. Ramya. "AI driven ECG arrhythmia diagnosis." MATEC Web of Conferences 392 (2024): 01149. http://dx.doi.org/10.1051/matecconf/202439201149.

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The accurate and timely diagnosis of cardiac arrhythmias is crucial for effective patient management and improved health outcomes. However, the precise identification of arrhythmias in electrocardiogram (ECG) data often requires specialized medical expertise, leading to potential delays and errors in diagnosis. To address these challenges, this project introduces an AI-driven system for ECG arrhythmia diagnosis. Employing advanced deep learning techniques, the proposed system leverages a comprehensive dataset of annotated ECG recordings to train a robust model capable of detecting and classify

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Zylla, Maura M., Uta Merle, Johannes A. Vey, et al. "Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19." Journal of Clinical Medicine 10, no. 1 (2021): 133. http://dx.doi.org/10.3390/jcm10010133.

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Background: Cardiac manifestation of COVID-19 has been reported during the COVID pandemic. The role of cardiac arrhythmias in COVID-19 is insufficiently understood. This study assesses the incidence of cardiac arrhythmias and their prognostic implications in hospitalized COVID-19-patients. Methods: A total of 166 patients from eight centers who were hospitalized for COVID-19 from 03/2020–06/2020 were included. Medical records were systematically analyzed for baseline characteristics, biomarkers, cardiac arrhythmias and clinical outcome parameters related to the index hospitalization. Predispos

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Liu, Yan, Hong-li Sun, Dan-lu Li, et al. "Choline produces antiarrhythmic actions in animal models by cardiac M3 receptors: improvement of intracellular Ca2+ handling as a common mechanism." Canadian Journal of Physiology and Pharmacology 86, no. 12 (2008): 860–65. http://dx.doi.org/10.1139/y08-094.

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It is well known that choline has protective effects on ischemic arrhythmias. We designed the present study to evaluate the antiarrhythmic effects of choline and to detect its related mechanisms in aconitine-induced rat and ouabain-induced guinea pig models of arrhythmia. Laser scanning confocal microscopy and patch-clamp technique were utilized to study the action of choline on intracellular calcium concentration and L-type calcium current (ICa-L) of cardiac myocytes. M3 receptor antagonist 4-DAMP (4-diphenylacetoxy-N-methylpiperidine-methiodide) was applied preliminarily to evaluate the role

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Kim, Esther D., Elsayed Z. Soliman, Josef Coresh, Kunihiro Matsushita, and Lin Yee Chen. "Two-Week Burden of Arrhythmias across CKD Severity in a Large Community-Based Cohort: The ARIC Study." Journal of the American Society of Nephrology 32, no. 3 (2021): 629–38. http://dx.doi.org/10.1681/asn.2020030301.

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BackgroundCKD is associated with sudden cardiac death and atrial fibrillation (AF). However, other types of arrhythmia and different measures of the burden of arrhythmias, such as presence and frequency, have not been well characterized in CKD.MethodsTo quantify the burden of arrhythmias across CKD severity in 2257 community-dwelling adults aged 71–94 years, we examined associations of major arrhythmias with CKD measures (eGFR and albuminuria) among individuals in the Atherosclerosis Risk in Communities study. Participants underwent 2 weeks of noninvasive, single-lead electrocardiogram monitor

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Guarracini, Fabrizio, Massimo Tritto, Antonio Di Monaco, et al. "Stereotactic Arrhythmia Radioablation Treatment of Ventricular Tachycardia: Current Technology and Evolving Indications." Journal of Cardiovascular Development and Disease 10, no. 4 (2023): 172. http://dx.doi.org/10.3390/jcdd10040172.

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Ventricular tachycardia in patients with structural heart disease is a significant cause of morbidity and mortality. According to current guidelines, cardioverter defibrillator implantation, antiarrhythmic drugs, and catheter ablation are established therapies in the management of ventricular arrhythmias but their efficacy is limited in some cases. Sustained ventricular tachycardia can be terminated by cardioverter-defibrillator therapies although shocks in particular have been demonstrated to increase mortality and worsen patients’ quality of life. Antiarrhythmic drugs have important side eff

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Pereira, Helder, Steven Niederer, and Christopher A. Rinaldi. "Electrocardiographic imaging for cardiac arrhythmias and resynchronization therapy." EP Europace 22, no. 10 (2020): 1447–62. http://dx.doi.org/10.1093/europace/euaa165.

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Abstract Use of the 12-lead electrocardiogram (ECG) is fundamental for the assessment of heart disease, including arrhythmias, but cannot always reveal the underlying mechanism or the location of the arrhythmia origin. Electrocardiographic imaging (ECGi) is a non-invasive multi-lead ECG-type imaging tool that enhances conventional 12-lead ECG. Although it is an established technology, its continuous development has been shown to assist in arrhythmic activation mapping and provide insights into the mechanism of cardiac resynchronization therapy (CRT). This review addresses the validity, reliabi

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Andelova, Katarina, Barbara Szeiffova Bacova, Matus Sykora, Peter Hlivak, Miroslav Barancik, and Narcis Tribulova. "Mechanisms Underlying Antiarrhythmic Properties of Cardioprotective Agents Impacting Inflammation and Oxidative Stress." International Journal of Molecular Sciences 23, no. 3 (2022): 1416. http://dx.doi.org/10.3390/ijms23031416.

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The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial fibrillation remains a serious global clinical issue, with ongoing need for novel approaches. Numerous experimental and clinical studies suggest that oxidative stress and inflammation are deleterious to cardiovascular health, and can increase heart susceptibility to arrhythmias. It is quite interesting, however, that various cardio-protective compounds with antiarrhythmic properties are potent anti-oxidative and anti-inflammatory agents. These most likely target the pro-arrhythmia primary mechanisms

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Perna, Francesco, Alessandro Telesca, Roberto Scacciavillani, et al. "Clinical Impact of Cardiac Fibrosis on Arrhythmia Recurrence after Ablation in Adults with Congenital Heart Disease." Journal of Cardiovascular Development and Disease 10, no. 4 (2023): 168. http://dx.doi.org/10.3390/jcdd10040168.

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Background. Adults with congenital heart disease (ACHD) are often affected by cardiac arrhythmias requiring catheter ablation. Catheter ablation in this setting represents the treatment of choice but is flawed by frequent recurrencies. Predictors of arrhythmia relapse have been identified, but the role of cardiac fibrosis in this setting has not been investigated. The aim of this study was to determine the role of the extension of cardiac fibrosis, detected by electroanatomical mapping, in predicting arrhythmia recurrencies after ablation in ACHD. Materials and Methods. Consecutive patients wi

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Eftekhari, Helen. "Pharmacotherapy in arrhythmias: an overview of anti-arrhythmic drug therapy." Journal of Prescribing Practice 2, no. 11 (2020): 582–88. http://dx.doi.org/10.12968/jprp.2020.2.11.582.

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The article aims to give an overview of the principles in anti-arrhythmic drug prescribing. Practitioners assessing cardiac patients are highly likely to review anti-arrhythmic drug therapies and need an understanding of the principles of therapy. The cardiac action potential is explained, followed by general principles involved in treating arrhythmias and prescribing decisions. An overview of the five classifications of anti-arrhythmic drugs is given, with examples of the main drugs in the classification and principles to consider within each. Finally anticoagulation is reviewed being a corne

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Soniwala, Mujtaba, Saadia Sherazi, Susan Schleede, et al. "Arrhythmia Burden in Patients with Indolent Lymphoma." Blood 136, Supplement 1 (2020): 6–7. http://dx.doi.org/10.1182/blood-2020-140053.

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Introduction Indolent Non-Hodgkin lymphomas (NHL) comprise a heterogeneous group of diseases including marginal zone lymphoma (MZL), lymphoplasmacytic lymphoma (LPL), small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL), and follicular lymphoma (FL). These compose a heterogenous group of disorders that frequently measures survival in years due to the long natural history of these diseases. Frequency and morbidity of cardiac arrhythmias in patients with indolent lymphoma is unknown, but recent observations note that arrhythmias are an increasing problem. Due to advances in treatmen

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Kwon, Soonil, So-Ryoung Lee, Eue-Keun Choi, et al. "Validation of Adhesive Single-Lead ECG Device Compared with Holter Monitoring among Non-Atrial Fibrillation Patients." Sensors 21, no. 9 (2021): 3122. http://dx.doi.org/10.3390/s21093122.

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There are few reports on head-to-head comparisons of electrocardiogram (ECG) monitoring between adhesive single-lead and Holter devices for arrhythmias other than atrial fibrillation (AF). This study aimed to compare 24 h ECG monitoring between the two devices in patients with general arrhythmia. Twenty-nine non-AF patients with a workup of pre-diagnosed arrhythmias or suspicious arrhythmic episodes were evaluated. Each participant wore both devices simultaneously, and the cardiac rhythm was monitored for 24 h. Selective ECG parameters were compared between the two devices. Two cardiologists i

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von Sanden, Felix, Svetlana Ptushkina, Julia Hock, et al. "Peak Oxygen Uptake on Cardiopulmonary Exercise Test Is a Predictor for Severe Arrhythmic Events during Three-Year Follow-Up in Patients with Complex Congenital Heart Disease." Journal of Cardiovascular Development and Disease 9, no. 7 (2022): 215. http://dx.doi.org/10.3390/jcdd9070215.

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Patients with congenital heart disease (CHD) are at increased risk for severe arrhythmia and sudden cardiac death (SCD). Although implantable cardioverter defibrillators (ICD) effectively prevent SCD, risk stratification for primary prophylaxis in patients with CHD remains challenging. Patients with complex CHD undergoing CPET were included in this single-center study. Univariable and backwards stepwise multivariable logistic regression models were used to identify variables associated with the endpoint of severe arrhythmic event during three years of follow-up. Cut-off values were established

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Zhu, Yujie, Isaac Shamblin, Efrain Rodriguez, et al. "Progressive cardiac arrhythmias and ECG abnormalities in the Huntington’s disease BACHD mouse model." Human Molecular Genetics 29, no. 3 (2019): 369–81. http://dx.doi.org/10.1093/hmg/ddz295.

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Abstract Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease. There is accumulating evidence that HD patients have increased prevalence of conduction abnormalities and compromised sinoatrial node function which could lead to increased risk for arrhythmia. We used mutant Huntingtin (mHTT) expressing bacterial artificial chromosome Huntington’s disease mice to determine if they exhibit electrocardiogram (ECG) abnormalities involving cardiac conduction that are known to increase risk of sudden arrhythmic death in humans. We obtained surface ECGs and analyzed arrhythmia s

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Falco, Raffaele, Chiara Tognola, Lorenzo Gigli, et al. "Idiopathic Ventricular Arrhythmias Originating from the Left Ventricular Summit: A Diagnostic and Therapeutic Challenge." Journal of Clinical Medicine 14, no. 12 (2025): 4261. https://doi.org/10.3390/jcm14124261.

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Premature ventricular contractions (PVCs) originating from the left ventricular summit (LVS) present a diagnostic and therapeutic challenge due to their complex anatomical location. The LVS includes an epicardial area of the left ventricle bordered by major coronary arteries, which has been increasingly recognized as an arrhythmic focus. Idiopathic ventricular arrhythmias from this area may exhibit specific electrocardiographic characteristics, making accurate localization essential for effective management. Methods: This narrative review explores the primary features of this arrhythmia, empha

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Graham, George M. "Evaluation of Fetal Arrhythmias." Donald School Journal of Ultrasound in Obstetrics and Gynecology 4, no. 1 (2010): 51–57. http://dx.doi.org/10.5005/jp-journals-10009-1129.

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Abstract Fetal arrhythmias are not uncommon. The diagnosis of a fetal arrhythmia is challenging and normally requires referral for a detailed fetal echocardiogram. The first step in the ultrasound evaluation should be distinguishing whether the arrhythmia is an irregular rhythm, a bradycardia, or a tachycardia. This can be done by evaluating the arrhythmia using simultaneous atrial and ventricular M-mode or pulsed Doppler. Although the majority of fetal arrhythmias are self-limited and benign, some are potentially life-threatening for the fetus and for these cases a multidisciplinary approach

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Abdelhafid, ERRABIH, EDDER Aymane, NSIRI Benayad, et al. "ECG Arrhythmia Classification Using Convolutional Neural Network." International Journal of Emerging Technology and Advanced Engineering 12, no. 7 (2022): 186–95. http://dx.doi.org/10.46338/ijetae0722_19.

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This study provides a thorough analysis of earlier DL techniques used to classify the ECG data. The large variability among individual patients and the high expense of labeling clinical ECG records are the main hurdles in automatically detecting arrhythmia by electrocardiogram (ECG). The classification of electrocardiogram (ECG) arrhythmias using a novel and more effective technique is presented in this research. A high-performance electrocardiogram (ECG)-based arrhythmic beats classification system is described in this research to develop a plan with an autonomous feature learning strategy an

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Deal, Barbara J., Constantine Mavroudis, Jeffrey Phillip Jacobs, Melanie Gevitz, and Carl Lewis Backer. "Arrhythmic complications associated with the treatment of patients with congenital cardiac disease: consensus definitions from the Multi-Societal Database Committee for Pediatric and Congenital Heart Disease." Cardiology in the Young 18, S2 (2008): 202–5. http://dx.doi.org/10.1017/s104795110800293x.

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AbstractA detailed hierarchal nomenclature of arrhythmias is offered with definition of its applications to diagnosis and complications. The conceptual and organizational approach to discussion of arrhythmias employs the following sequence: location – mechanism – aetiology – duration. The classification of arrhythmias is heuristically divided into an anatomical hierarchy: atrial, junctional, ventricular, or atrioventricular. Mechanisms are most simplistically classified as either reentrant, such as macro-reentrant atrial tachycardia, previously described as atrial flutter, or focal, such as au

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Harkness, Weston, Paula Watts, Michael Kopstein, Oliwier Dziadkowiec, Gregory Hicks, and Dmitriy Scherbak. "Correcting Hypokalemia in Hospitalized Patients Does Not Decrease Risk of Cardiac Arrhythmias." Advances in Medicine 2019 (September 24, 2019): 1–4. http://dx.doi.org/10.1155/2019/4919707.

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Background. It is currently standard practice to correct hypokalemia for the purpose of preventing cardiac arrhythmias in all hospitalized patients. However, the efficacy of this intervention has never been previously studied. Objective. The objective of our study was to evaluate whether patients without acute coronary syndrome or history of arrhythmias were at increased risk of clinically significant cardiac arrhythmias if their potassium level was not corrected to ≥3.5 mEq/L. Design. A retrospective case control study. Setting. A community hospital. Participants. We enrolled selected patient

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Wagner, Michael, Mirna S. Sadek, Nataliya Dybkova, et al. "Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression." International Journal of Molecular Sciences 22, no. 9 (2021): 4816. http://dx.doi.org/10.3390/ijms22094816.

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Background: Phosphodiesterases (PDE) critically regulate myocardial cAMP and cGMP levels. PDE2 is stimulated by cGMP to hydrolyze cAMP, mediating a negative crosstalk between both pathways. PDE2 upregulation in heart failure contributes to desensitization to β-adrenergic overstimulation. After isoprenaline (ISO) injections, PDE2 overexpressing mice (PDE2 OE) were protected against ventricular arrhythmia. Here, we investigate the mechanisms underlying the effects of PDE2 OE on susceptibility to arrhythmias. Methods: Cellular arrhythmia, ion currents, and Ca2+-sparks were assessed in ventricular

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Gausz, Flora Diana, Kom Nangob Manuela Lena, Paul Emmanuel Gedeon, et al. "Arrhythmia Detection in Atrioventricular, Single-Lead, Floating Atrial Dipole ICD Systems Compared with Conventional Single- and Dual-Chamber Defibrillators." Journal of Cardiovascular Development and Disease 11, no. 12 (2024): 386. https://doi.org/10.3390/jcdd11120386.

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Background: An atrioventricular defibrillator system with a floating atrial dipole (VDD ICD) can provide atrial sensing by a single lead. Our aim was to compare the arrhythmia detection efficacy of VDD ICDs with conventional single- (VVI) and dual-chamber (DDD) defibrillators. Methods: Data from consecutive patients undergoing ICD implantation were retrospectively analyzed. The primary endpoint was the incidence of device-detected, new-onset atrial arrhythmias, while secondary endpoints were sensing parameters, complication rates, incidence of appropriate/inappropriate ICD therapy, arrhythmic/

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Leren, Ida Skrinde, Jørg Saberniak, Eman Majid, Trine F. Haland, Thor Edvardsen, and Kristina H. Haugaa. "Abstract 9815: Nadolol Seems to Be Superior to Selective Beta Blockers in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia: Is a Smaller Arrhythmic Window Part of the Explanation?" Circulation 132, suppl_3 (2015). http://dx.doi.org/10.1161/circ.132.suppl_3.9815.

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Introduction: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inheritable arrhythmogenic disease, and typically presents as syncope or sudden cardiac death during exercise. Beta blockers are first choice therapy but little is known about antiarrhythmic effects of different beta blockers in CPVT. Nadolol has shown superior antiarrhythmic effect in other cardiomyopathies. Hypothesis: We hypothesized that nadolol is superior to selective beta blockers in arrhythmia protection in CPVT patients. Methods: We included 34 CPVT patients (age 34±19 yrs, 44% female, 88% RYR2 mutation p

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Dammeyer, Kristen L., Kara S. Motonaga, Henry Chubb, Elizabeth L. Profita, and Seth A. Hollander. "Early Post‐Operative Versus Late Arrhythmias After Heart Transplant at a Pediatric Center: Incidence, Management, and Outcomes." Pediatric Transplantation 29, no. 5 (2025). https://doi.org/10.1111/petr.70094.

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ABSTRACTBackgroundArrhythmias in pediatric heart transplant patients have historically raised concerns for acute rejection, often prompting invasive evaluation and empiric treatment. Despite this, the association of post‐transplant arrhythmias with adverse outcomes remains understudied.MethodsThis is a retrospective single center review of pediatric patients who underwent heart transplant between 01/2014 and 12/2022. Arrhythmias were classified as early (</= 14 days post‐transplant) or late (> 14 days post‐transplant) and as atrial, ventricular, or bradyarrhythmias. Adverse outcomes incl

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Senarath, Sachintha, Pavitra Nanayakkara, Anna L. Beale, Monique Watts, David M. Kaye, and Shane Nanayakkara. "Diagnosis and management of arrhythmias in pregnancy." EP Europace, December 14, 2021. http://dx.doi.org/10.1093/europace/euab297.

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Abstract Arrhythmias are the most common cardiac complications occurring in pregnancy. Although the majority of palpitations in pregnancy may be explained by atrial or ventricular premature complexes, the full spectrum of arrhythmias can occur. In this article, we establish a systematic approach to the evaluation and management of arrhythmias in pregnancy. Haemodynamically unstable arrhythmias warrant urgent cardioversion. For mild cases of benign arrhythmia, treatment is usually not needed. Symptomatic but haemodynamically stable arrhythmic patients should first undergo a thorough evaluation

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Smoczyńska, Agnieszka, Vera Loen, David J. Sprenkeler, et al. "Short‐Term Variability of the QT Interval Can be Used for the Prediction of Imminent Ventricular Arrhythmias in Patients With Primary Prophylactic Implantable Cardioverter Defibrillators." Journal of the American Heart Association 9, no. 23 (2020). http://dx.doi.org/10.1161/jaha.120.018133.

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Background Short‐term variability of the QT interval (STV QT ) has been proposed as a novel electrophysiological marker for the prediction of imminent ventricular arrhythmias in animal models. Our aim is to study whether STV QT can predict imminent ventricular arrhythmias in patients. Methods and Results In 2331 patients with primary prophylactic implantable cardioverter defibrillators, 24‐hour ECG Holter recordings were obtained as part of the EU‐CERT‐ICD (European Comparative Effectiveness Research to Assess the Use of Primary Prophylactic Implantable Cardioverter Defibrillators) study. ECG

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Zalavadia, Dipen, Srija Shanker, Ashish Nepal, et al. "Abstract 10109: High Prevalence and Significant Impact of Arrhythmias on Healthcare Resource Utilization in Hospitalizations of Patients with Prior (corrected) Congenital Heart/Circulatory Disease." Circulation 144, Suppl_1 (2021). http://dx.doi.org/10.1161/circ.144.suppl_1.10109.

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Introduction: Even after surgical correction, adults with a previously corrected Congenital Heart Disease (CHD) may remain at a significantly elevated risk of arrhythmias. However, there is not much known about the prevalence, comorbidity burden, and impact of arrhythmia in these patients. Methods: Using the National Inpatient Sample (2015 Oct-2017), adult admissions with previously corrected CHD were identified. The primary outcome was the prevalence of arrhythmia and secondary outcomes included comorbidities and outcomes between the arrhythmic vs. non-arrhythmic cohort. Results: Of 19,395 ad

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Sherazi, Saadia, Susan Schleede, Scott McNitt, et al. "Arrhythmogenic Cardiotoxicity Associated With Contemporary Treatments of Lymphoproliferative Disorders." Journal of the American Heart Association, March 9, 2023. http://dx.doi.org/10.1161/jaha.122.025786.

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Background There are limited data on risk of arrhythmias among patients with lymphoproliferative disorders. We designed this study to determine the risk of atrial and ventricular arrhythmia during treatment of lymphoma in a real‐world setting. Methods and Results The study population comprised 2064 patients included in the University of Rochester Medical Center Lymphoma Database from January 2013 to August 2019. Cardiac arrhythmias—atrial fibrillation/flutter, supraventricular tachycardia, ventricular arrhythmia, and bradyarrhythmia—were identified using International Classification of Disease

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Yinadsawaphan, Thanaboon, Mustafa Suppah, Srekar N. Ravi, JUAN FARINA, Robert L. Scott, and Dan Sorajja. "Abstract 14098: Epidemiology and Clinical Outcomes of Cardiac Arrhythmias in Pulmonary Arterial Hypertension." Circulation 148, Suppl_1 (2023). http://dx.doi.org/10.1161/circ.148.suppl_1.14098.

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Background: There is limited evidence regarding the impact of cardiac arrhythmias in patients with pulmonary arterial hypertension (PAH). We aim to comprehensively investigate the epidemiology and clinical outcomes of cardiac arrhythmias in patients with PAH. Methods: In a retrospective cohort study including 512 PAH patients from 2001-2021 at 3 Mayo Clinic sites, PAH patients were identified via echocardiogram, pulmonary function tests, and right heart catheterization. Demographic data at PAH diagnosis and clinical outcomes over a 10-year period were collected. The PAH patients were categoriz

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