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Journal articles on the topic 'Artemisia Artemisia Antimalarials'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Veronica, Elvina, Irene Amelia, Kezia Angelina Yunatan, Ni Kadek Sinta Dwi Chrismayanti, and Agung Nova Mahendra. "Potensi Kombinasi Ekstrak Daun Kelor (Moringa oliefera) dan Artemisia (Artemisia annua) Sebagai Antimalaria Plasmodium falciparum." Jurnal Ilmiah Kesehatan Sandi Husada 12, no. 2 (2020): 831–41. http://dx.doi.org/10.35816/jiskh.v12i2.415.

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Penatalaksanaan malaria seperti kloroquine dan Artemisin Combination Therapy dapat memberikan efek samping dan sudah mengalami resistensi sehingga diperlukan alternatif pengobatan lain. Metode penulisan ini menggunakan kajian pustaka dari sejumlah literatur valid dan relevan. Artemisinin pada tanaman Artemisia annua menghambat PfATPase6 sehingga membuat homeostasis Ca plasmodium terganggu dan menghambat pertumbuhan plasmodium. Enzim cysteine protease, inhibitor ALLN, Plasmepsin-2 serta Plasmepsin-1 berfungsi menghancurkan plasmodium pada fase trophozoite dan schizont dengan mendegradasi protei

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Liu, Rong, Jinbiao Wang, Mu Xiao, Xiewang Gao, Jin Chen, and Yanjiao Dai. "AaCOI1, Encoding a CORONATINE INSENSITIVE 1-Like Protein of Artemisia annua L., Is Involved in Development, Defense, and Anthocyanin Synthesis." Genes 11, no. 2 (2020): 221. http://dx.doi.org/10.3390/genes11020221.

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Artemisia annua is an important medicinal plant producing the majority of the antimalarial compound artemisinin. Jasmonates are potent inducers of artemisinin accumulation in Artemisisa annua plants. As the receptor of jasmonates, the F-box protein COI1 is critical to the JA signaling required for plant development, defense, and metabolic homeostasis. AaCOI1 from Artemisia annua, homologous to Arabidopsis AtCOI1, encodes a F-box protein located in the nuclei. Expressional profiles of the AaCOI1 in the root, stem, leaves, and inflorescence was investigated. The mRNA abundance of AaCOI1 was the

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3

SHAHRAJABIAN, Mohamad H., Wenli SUN, and Qi CHENG. "Exploring Artemisia annua L., artemisinin and its derivatives, from traditional Chinese wonder medicinal science." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 48, no. 4 (2020): 1719–41. http://dx.doi.org/10.15835/nbha48412002.

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Artemisia annua L. (Chinese wormwood herb, Asteraceae) synthesizes artemisinin, which is known as qinghaosu, considers as a unique sesquiterpene endoperoxide lactone. In traditional Chinese medicine, it has been used for the treatment of fevers and haemorrhoides. More researches on Artemisia annua L. and its derivatives, especially artemisinin and other metabolites will help to increase the knowledge and value of A. annua and its constituents. Phenolics from Artemisia annua consists of coumarins, flavones, flavonols, phenolic acids, and miscellaneous. Artemisinin has attracted much attention f

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4

Ekiert, Halina, Joanna Świątkowska, Paweł Klin, Agnieszka Rzepiela, and Agnieszka Szopa. "Artemisia annua – Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications." Planta Medica 87, no. 08 (2021): 584–99. http://dx.doi.org/10.1055/a-1345-9528.

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Abstract Artemisia annua (annual mugwort) is a species that has long been used in traditional Asian medicine, mainly Chinese and Hindu. The species is widespread and known as a medicinal plant not only in Asia but also in Europe, in both Americas, and Australia. The species has become a subject of particular interest due to the 2015 Nobel Prize awarded for detecting the sesquiterpene lactone artemisinin in it and proving its antimalarial activities. The raw materials obtained from this species are Artemisiae annuae folium and Artemisiae annuae herba. The leaves are a raw material in the Chines

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5

Muti’ah, Roihatul, Elok Kamilah Hayati, and Asnal Fatati. "Combination of Calotropis gigantea Radix Extract and Artemisin as an Antimalarial Agent Against Plasmodium berghei." Journal of Islamic Pharmacy 1, no. 1 (2016): 12. http://dx.doi.org/10.18860/jip.v1i1.3456.

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<p><em>Calotropis gigantea</em> radix is one of plant which has bioactive component as antimalarial.The purpose of this research are to know antimalarial activity from combination of <em>Calotropis gigantea</em> radix extract and artemisin. The research consist of extraction of <em>Calotropis gigantea</em> radix was done with extraction maseration method. Extraction was performed by maseration with 80% ethanol solvent. Concentrated extract was <em>in vivo </em>antimalarial tested to animal model. Mice were peritoneal infected with 10<sup

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6

Choi, J. K., B. S. Kim, I. Y. Choi, S. E. Cho, and H. D. Shin. "First Report of Powdery Mildew Caused by Golovinomyces artemisiae on Artemisia annua in Korea." Plant Disease 98, no. 7 (2014): 1010. http://dx.doi.org/10.1094/pdis-01-14-0055-pdn.

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Artemisia annua L., known as sweet wormwood or sweet annie, is native to temperate Asia, but is naturalized throughout the world. It produces artemisinin, a potent antimalarial drug that is also effective in treating other parasitic diseases (4). In August 2013, hundreds of plants showing typical symptoms of powdery mildew were found in Seoul (37°36′29.4″ N 127°02′38.3″ E), Korea. Powdery mildew colonies first appeared as thin white patches, which progressed to abundant hyphal growth on both sides of the leaves, stems, and inflorescence. As symptoms continued to develop, the leaves became dist

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7

De Magalhães, P. M., B. Pereira, and A. Sartoratto. "YIELDS OF ANTIMALARIAL ARTEMISIA ANNUA L. SPECIES." Acta Horticulturae, no. 629 (January 2004): 421–24. http://dx.doi.org/10.17660/actahortic.2004.629.55.

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8

Mukhamatkhanova, Rimma Fail'yevna, Khayrulla Mamadievich Bobakulov, Il'dar Dzhamil'yevich Sham’yanov, et al. "COMPONENTS OF ARTEMISIA SOGDIANA." chemistry of plant raw material, no. 1 (March 5, 2020): 207–14. http://dx.doi.org/10.14258/jcprm.2020015548.

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Phytochemical research and effective use of medicinal flora in the future create the basis for the development of the domestic pharmaceutical industry and allow not only to fill the deficit of drugs, but also contribute to the development of new, environmentally friendly and a number of qualities of unique, export-oriented preparations. The plants of the genus Artemisia L. are rich sources of biologically active secondary metabolites. Phytochemical study of secondary metabolites of plants of the genus Artemisia has led to the creation on their basis, in particular, on the sesquiterpene l

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9

Mitiuchkina, T. Yu, A. S. Pushin, A. K. Tzareva, A. M. Vainstein, and S. V. Dolgov. "Agrobacteium Transformation of Tobacco with a Genetic Module of Antimalarial Agent Artemisinin Biosynthesis." Biotekhnologiya 36, no. 3 (2020): 34–45. http://dx.doi.org/10.21519/0234-2758-2020-36-3-34-45.

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Artemisinin-based medicines are the most effective treatment for malaria. To date, the wormwood plants (Artemisia annua L.) are the main source of artemisinin. Due to the limited nature of this source, considerable efforts are directed towards the development of methods for artemisinin production via heterologous expression systems. We used in this study agrobacterial transformation to transfer the genetic module of the artemisinin biosynthesis pathway into plants and then analyzed its transcription in a heterologous host. Tobacco plants were transformed with the artemisinin biosynthesis genes

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10

Pellicer, Jaume, C. Haris Saslis-Lagoudakis, Esperança Carrió, et al. "A phylogenetic road map to antimalarial Artemisia species." Journal of Ethnopharmacology 225 (October 2018): 1–9. http://dx.doi.org/10.1016/j.jep.2018.06.030.

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11

Panda, Sagorika, Jyoti Ranjan Rout, Pallabi Pati, Manoranjan Ranjit, and Santi Lata Sahoo. "Antimalarial activity of Artemisia nilagirica against Plasmodium falciparum." Journal of Parasitic Diseases 42, no. 1 (2017): 22–27. http://dx.doi.org/10.1007/s12639-017-0956-9.

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12

Bala, Moumita, Sandeep Lahiry, Shouvik Choudhury, et al. "Antimalarials: Pre-Clinical development update." Asian Journal of Medical Sciences 8, no. 5 (2017): 1–3. http://dx.doi.org/10.3126/ajms.v8i5.17530.

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Diverse strategies exist for the development of novel antimalarials drug to tackle the increasing incidence of artemisin resistance. New molecules have been developed which hold a promise to cater to this unmet need. We discuss few drugs currently under pre-clinical development that have shown encouraging results.Asian Journal of Medical Sciences Vol.8(5) 2017 1-3

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13

Guo, Jin, Armand W. Guiguemde, Annael Bentura-Marciano, et al. "Synthesis of Artemiside and Its Effects in Combination with Conventional Drugs against Severe Murine Malaria." Antimicrobial Agents and Chemotherapy 56, no. 1 (2011): 163–73. http://dx.doi.org/10.1128/aac.05006-11.

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ABSTRACTThis research describes the use of novel antimalarial combinations of the new artemisinin derivative artemiside, a 10-alkylamino artemisinin. It is a stable, highly crystalline compound that is economically prepared from dihydroartemisinin in a one-step process. Artemiside activity was more pronounced than that of any antimalarial drug in use, both inPlasmodium falciparumculture andin vivoin a murine malaria model depicting cerebral malaria (CM).In vitrohigh-throughput testing of artemiside combinations revealed a large number of conventional antimalarial drugs with which it was additi

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14

Ferreira, Jorge F. S., James E. Simon, and Jules Janick. "Artemisinin (Qinghaosu) Production in Artemisia annua." HortScience 30, no. 4 (1995): 888B—888. http://dx.doi.org/10.21273/hortsci.30.4.888b.

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Artemisinin (qinghaosu), an endoperoxide sesquiterpene lactone with antimalarial activity and little human toxicity, is produced in A. annua L., a short-day plant with the critical photoperiod of 13.5 h. Artemisinin peaks at full flowering when it is 11 times higher in inflorescences than in leaves. Supplementation of MS medium with BA, kinetin, CCC, or daminozide decreased content in shoot cultures as compared to the control, with the exception of CCC at 6.3 μM. Artemisinin content (percent dry weight) in this experiment did not correlate with shoot number (r = –0.198) but was highly correlat

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15

Klayman, D. L. "QUINGHAOSU (ARTEMISIN): AN ANTIMALARIAL DRUG FROM CHINA." Pediatric Infectious Disease Journal 4, no. 6 (1985): 709. http://dx.doi.org/10.1097/00006454-198511000-00046.

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16

Woerdenbag, Herman J., Charles B. Lugt, and Niesko Pras. "Artemisia annua L.: a source of novel antimalarial drugs." Pharmaceutisch Weekblad Scientific Edition 12, no. 5 (1990): 169–81. http://dx.doi.org/10.1007/bf01980041.

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17

Elfawal, Mostafa A., Melissa J. Towler, Nicholas G. Reich, Douglas Golenbock, Pamela J. Weathers, and Stephen M. Rich. "Dried Whole Plant Artemisia annua as an Antimalarial Therapy." PLoS ONE 7, no. 12 (2012): e52746. http://dx.doi.org/10.1371/journal.pone.0052746.

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18

Cockram, James, Colin Hill, Corrinne Burns, et al. "Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin." Plant Genetic Resources 10, no. 2 (2012): 152–54. http://dx.doi.org/10.1017/s1479262112000159.

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The antimalarial drug artemisinin (ART) is commercially extracted from the medicinal plant Artemisia annua L. Here, we report the screening of 70 A. annua plants representing 14 diverse germplasm accessions sourced from around the world, and identify lines containing >2% ART. These extremely high-yielding individuals have been maintained as vegetative clones, and they represent promising germplasm resources for future A. annua breeding programmes.

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19

WANGPAN, Tonlong, Luk Bahadur CHETRY, Jambey TSERING, Tapi TAKA, and Sumpam TANGJANG. "Anti-Malarial Plants of Jonai, India: an Ethnobotanical Approach." Notulae Scientia Biologicae 8, no. 1 (2016): 27–32. http://dx.doi.org/10.15835/nsb819750.

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North-East India represents a unique ecosystem with treasured medicinal plant wealth closely related with Folk medicines. A large number of plants having medicinal properties and their folk uses have remained confined to the natives of this region. The tribal community of Jonai, Assam was explored to expose the indigenous herbal remedy for malaria. Sixteen antimalarial plants belonging to 13 families were reported. The analysis revealed highest fidelity level (FL) value for Ajuga integrifolia (100%) followed by Ricinus communis (94%), Alstonia scholaris (88%), Oroxylum indicum (86%) and Achyra

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20

Debnath, Chhanda, Ernst Haslinger, and Astrid Ortner. "A Simple Differential Pulse Polarographic Method for the Determination of Artemisinin in Artemisia Annua." Natural Product Communications 1, no. 6 (2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100611.

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A reliable and simple differential pulse polarographic method is presented for the determination of the antimalarial artemisinin in Artemisia annua. The polarographic behaviour of artemisinin was examined in various buffer systems over the pH range 2–10. Artemisinin was irreversibly reduced at the dropping mercury electrode. In 0.1 M KH2PO4, pH 5.5, mixed with methanol (7:3; v/v), the differential pulse polarograms exhibited reproducible peaks at 0.0 V vs. Ag/AgCl and a plot of peak height against concentration of artemisinin was found to be linear over the range 6.4 × 10−7 - 3.2 × 10−5 mol/L

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de Magalhães, P. M., B. Pereira, A. Sartoratto, J. de Oliveira, and N. Debrunner. "NEW HYBRID LINES OF THE ANTIMALARIAL SPECIES ARTEMISIA ANNUA L." Acta Horticulturae, no. 502 (December 1999): 377–82. http://dx.doi.org/10.17660/actahortic.1999.502.62.

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22

ZIFFER, H., R. J. HIGHET, and D. L. KLAYMAN. "ChemInform Abstract: Artemisinin: An Endoperoxidic Antimalarial from Artemisia annua L." ChemInform 28, no. 52 (2010): no. http://dx.doi.org/10.1002/chin.199752305.

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23

Opsenica, Dejan, and Bogdan Solaja. "Antimalarial peroxides." Journal of the Serbian Chemical Society 74, no. 11 (2009): 1155–93. http://dx.doi.org/10.2298/jsc0911155o.

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The problem of endemic malaria continues unabated globally. Malaria affects 40 % of the global population, causing an estimated annual mortality of 1.5-2.7 million people. The World Health Organization (WHO) estimates that 90 % of these deaths occur in sub-Saharan Africa among infants under the age of five. While a vaccine against malaria continues to be elusive, chemotherapy remains the most viable alternative towards treatment of the disease. During last years, the situation has become urgent in many ways, but mainly because of the development of chloroquine-resistant (CQR) strains of Plasmo

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Weathers, P., T. Smith, D. Hemmavanh, E. Follansbee, J. Ryan, and R. Cheetham. "PRODUCTION OF THE ANTIMALARIAL, ARTEMISININ, BY TRANSFORMED ROOTS OF ARTEMISIA ANNUA." Acta Horticulturae, no. 426 (August 1996): 157–64. http://dx.doi.org/10.17660/actahortic.1996.426.17.

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25

Xiao, Ling, Hexin Tan, and Lei Zhang. "Artemisia annua glandular secretory trichomes: the biofactory of antimalarial agent artemisinin." Science Bulletin 61, no. 1 (2016): 26–36. http://dx.doi.org/10.1007/s11434-015-0980-z.

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26

Bhat, Khursheed A., Syed Naseer, Ifshana Gani, et al. "Isolation and Identification of Cytotoxic and Antimalarial Constituents from Artemisia moorcroftiana." ChemistrySelect 6, no. 5 (2021): 962–67. http://dx.doi.org/10.1002/slct.202003944.

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27

Bégué, J. P., and D. Bonnet-Delpon. "The future of antimalarials: Artemisins and synthetic endoperoxides." Drugs of the Future 30, no. 5 (2005): 509. http://dx.doi.org/10.1358/dof.2005.030.05.901987.

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28

Dunay, Ildiko R., Wing Chi Chan, Richard K. Haynes, and L. David Sibley. "Artemisone and Artemiside Control Acute and Reactivated Toxoplasmosis in a Murine Model." Antimicrobial Agents and Chemotherapy 53, no. 10 (2009): 4450–56. http://dx.doi.org/10.1128/aac.00502-09.

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ABSTRACT Immunocompromised patients are at risk of developing toxoplasmosis, and although chemotherapy is available, standard treatments are often complicated by severe side effects. Artemisinin is a new highly potent antimalarial drug that has activity against Toxoplasma gondii in vitro. However, artemisinin derivatives have previously been ineffective in vivo using a rat model of toxoplasmosis. In the present study, the efficacy of several new artemisinin derivates was investigated for treatment of mice infected with the parasite Toxoplasma gondii. Artemiside and artemisone displayed better

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Avery, Mitchell A., Wesley K. M. Chong, and Clive Jennings-White. "Stereoselective total synthesis of (+)-artemisinin, the antimalarial constituent of Artemisia annua L." Journal of the American Chemical Society 114, no. 3 (1992): 974–79. http://dx.doi.org/10.1021/ja00029a028.

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30

Lwin, Myint, Chit Maun, and Kyin Hla Aye. "Trial of antimalarial potential of extracts of Artemisia annua grown in Myanmar." Transactions of the Royal Society of Tropical Medicine and Hygiene 85, no. 4 (1991): 449. http://dx.doi.org/10.1016/0035-9203(91)90213-i.

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31

Misra, Himanshu, Darshana Mehta, B. K. Mehta, and D. C. Jain. "Microwave-Assisted Extraction Studies of Target Analyte Artemisinin from Dried Leaves of Artemisia annua L." Organic Chemistry International 2013 (March 14, 2013): 1–6. http://dx.doi.org/10.1155/2013/163028.

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Artemisia annua L. (Asteraceae) is an annual herb native of Asia. This plant has been used for many centuries in traditional Chinese medicine for the treatment of fever and malaria. Conventional methods for the extraction of artemisinin from A. annua including solvent extraction, Soxhlet extraction, and heat reflux extraction are characterized by long extraction times and the consumption of large volume of solvents. A simple, rapid, and precise microwave-assisted extraction process was optimized for fast sample preparation for the faster quantitative determination of artemisinin, potential new

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32

Bryson, Charles T., and Edward M. Croom. "Herbicide Inputs for a New Agronomic Crop, Annual Wormwood (Artemisia annua)." Weed Technology 5, no. 1 (1991): 117–24. http://dx.doi.org/10.1017/s0890037x00033376.

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Annual wormwood has been cultivated on a small scale for production of the artemisinin class of antimalarial drugs in sufficient quantities for preclinical and clinical trials. Large scale cultivation will require a reliable, efficient crop production system. Production systems using 32 herbicides alone or in combinations were evaluated in growth chamber, greenhouse, and field experiments at Stoneville, MS from 1985 through 1988. The herbicide treatments that provided the best weed control were (A) metolachlor at 2.2 kg ai ha-1preemergence (PRE), (B) chloramben at 2.2 kg ai ha-1(PRE), or (C) t

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Engeu, PO, F. Omujall, M. Agwaya, H. Kyakulaga, and C. Obua. "Variations in antimalarial components of Artemisia annua Linn from three regions of Uganda." African Health Sciences 15, no. 3 (2015): 828. http://dx.doi.org/10.4314/ahs.v15i3.17.

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34

Goel, Divya, Vijender Singh, Mohammed Ali, Gopal Rao Mallavarupu, and Sushil Kumar. "Essential oils of petal, leaf and stem of the antimalarial plant Artemisia annua." Journal of Natural Medicines 61, no. 2 (2006): 187–91. http://dx.doi.org/10.1007/s11418-006-0112-9.

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Péterfi, Orsolya, and Erzsébet Domokos. "Mutualistic and Endophytic Microorganisms of Artemisia Annua: Description, Role and Use." Acta Biologica Marisiensis 1, no. 2 (2018): 5–21. http://dx.doi.org/10.2478/abmj-2018-0009.

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Abstract Artemisia annua is an important medical plant that produces artemisinin used for its antimalarial, antibacterial and antifungal effects in modern medicine. The high demand and low artemisinin content in plants (0.01-2 %) has led to studies about alternative methods to increase yield. Biofertilizers (beneficial microbes and/or biological products that colonize roots, improve plant nutrition and growth) have been reported affecting secondary metabolism and the production of active ingredients of herbs. The purpose of this paper is to draw attention to the current status of the research

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Lapenna, Silvia, Maria Camilla Bergonzi, Franco Francesco Vincieri, and Anna Rita Bilia. "Comparative Analysis of Antimalarial Principles in Artemisia Annua L. Herbal Drugs from East Africa." Natural Product Communications 3, no. 12 (2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301213.

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Malaria mortality continues to increase across the world and represents the most important parasitic disease of man. Artemisia annua L. (Asteraceae) has been used to treat fevers in China for over two millennia and recently the clinical efficacy of teas and decoctions derived from this species have been demonstrated, using high artemisinin-yielding plants. Therefore, it is important to verify the artemisinin levels in local cultivations in areas where malaria is endemic and to assess how different geographical and climatic conditions may affect the efficacy of traditional treatments. In this s

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Woerdenbag, Herman J., Jos F. J. Lüers, Wim van Uden, Niesko Pras, Theo M. Malingré, and A. Wilhelm Alfermann. "Production of the new antimalarial drug artemisinin in shoot cultures of Artemisia annua L." Plant Cell, Tissue and Organ Culture 32, no. 2 (1993): 247–57. http://dx.doi.org/10.1007/bf00029850.

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AVERY, M. A., W. K. M. CHONG, and C. JENNINGS-WHITE. "ChemInform Abstract: Stereoselective Total Synthesis of (+)-Artemisinin, the Antimalarial Constituent of Artemisia annua L." ChemInform 23, no. 25 (2010): no. http://dx.doi.org/10.1002/chin.199225281.

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Gruessner, Brian M., and Pamela J. Weathers. "In vitro analyses of Artemisia extracts on Plasmodium falciparum suggest a complex antimalarial effect." PLOS ONE 16, no. 3 (2021): e0240874. http://dx.doi.org/10.1371/journal.pone.0240874.

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Dried-leaf Artemisia annua L. (DLA) antimalarial therapy was shown effective in prior animal and human studies, but little is known about its mechanism of action. Here IC50s and ring-stage assays (RSAs) were used to compare extracts of A. annua (DLAe) to artemisinin (ART) and its derivatives in their ability to inhibit and kill Plasmodium falciparum strains 3D7, MRA1252, MRA1240, Cam3.11 and Cam3.11rev in vitro. Strains were sorbitol and Percoll synchronized to enrich for ring-stage parasites that were treated with hot water, methanol and dichloromethane extracts of DLA, artemisinin, CoArtem™,

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40

Nahrevanian, Hossein, Bayram Sheykhkanlooye Milan, Masoud Kazemi, Reza Hajhosseini, Soudeh Soleymani Mashhadi, and Shahab Nahrevanian. "Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts." Malaria Research and Treatment 2012 (January 23, 2012): 1–8. http://dx.doi.org/10.1155/2012/727032.

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The aim of this study is pharmacochemistry of Iranian flora Artemisia sieberi and its antimalarial effects on Plasmodium berghei in vivo. This is the first application of A. sieberi for treatment of murine malaria. A. sieberi were collected at flowering stage from the Khorassan and Semnan provinces of Iran; the aerial parts were air-dried at room temperature and then powdered. The powder was macerated in methanol, filtered with Bokhner hopper and solvent was separated in rotary evaporator. Total herbal extract was subsequently processed for ether and chloroform extracts preparation. The toxici

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GHASSEMI, Bita, Fatemeh DEHGHAN NAYERI, and Ramin HOSSEINI. "The Impact of Carbon Source, Explants and Growth Regulators on Callogenesis and Organogenesis of Artemisia annua." Notulae Scientia Biologicae 7, no. 4 (2015): 475–85. http://dx.doi.org/10.15835/nsb749596.

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Artemisinin, a sesquiterpene lactone isolated from Artemisia annua L. plant is known for its antimalarial activity. The low content of artemisinin has stimulated researchers to enhance its production through biotechnological approaches such as tissue culture. The present study was initiated to study the effect of some important factors alone and in combination, on the callogenesis and organogenesis of Artemisia annua. The type of carbon source had a significant effect on NAA efficiency to callogenesis of A. annua, whereas the best callogenesis of A. absinthium was observed at 2 mg/L BAP + 30 g

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Bilia, Anna Rita, Marcel Kaiser, Franco Francesco Vincieri, and Deniz Tasdemir. "Antitrypanosomal and Antileishmanial Activities of Organic and Aqueous Extracts of Artemisia Annua." Natural Product Communications 3, no. 12 (2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301204.

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Artemisia annua is an herbal drug with profound antimalarial activity, which can be ascribed to the sesquiterpene lactone artemisinin. Artemisinin also shows efficacy against other parasitic protozoan species, such as Trypanosoma and Leishmania, however trypanocidal and leishmanicidal effects of A. annua extracts have not been reported so far. In the current study, we evaluated the in vitro growth inhibitory activity of a number of organic and aqueous A. annua extracts, including tinctures, infusions and decoctions against three parasitic protozoa, T. brucei rhodesiense, T. cruzi and L. donova

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Tiwari, Mohit K., Dharmendra K. Yadav, and Sandeep Chaudhary. "Recent Developments in Natural Product Inspired Synthetic 1,2,4- Trioxolanes (Ozonides): An Unusual Entry into Antimalarial Chemotherapy." Current Topics in Medicinal Chemistry 19, no. 10 (2019): 831–46. http://dx.doi.org/10.2174/1568026619666190412104042.

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According to WHO “World health statistics 2018”, malaria alongside acute respiratory infections and diarrhoea, is one of the major infectious disease causing children’s death in between the age of 1-5 years. Similarly, according to another report (2016) malaria accounts for approximately 3.14% of the total disease burden worldwide. Although malaria has been widely eradicated in many parts of the world, the global number of cases continues to rise due to the rapid spread of malaria parasites that are resistant to antimalarial drugs. Artemisinin (8), a major breakthrough in the antimalarial chem

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Silva, Elviscley de Oliveira, Ricardo Neves Marreto, Edemilson Cardoso da Conceição, and Maria Teresa Bara. "Preparation of pellets containing a standardized Artemisia annua L. extract by extrusion-spheronization." Revista Fitos 15, no. 1 (2021): 84–92. http://dx.doi.org/10.32712/2446-4775.2021.1063.

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Artemisinin, the major substance with antimalarial activity of Artemisia annua L., is a poorly water-soluble drug. The development of pellets containing a standardized hydroethanolic extract of A. annua may overcome these drawbacks while offer an intermediate product with good technological properties for subsequent tablet manufacture. This work aimed to obtain and characterize A. annua pellets using the extrusion-spheronization technique. The extract was prepared by percolation and artemisinin content was determined using a validated HPLC method. The standardized extract was then used as a li

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Fang, Xin, Jian-Xu Li, Jin-Quan Huang, You-Li Xiao, Peng Zhang, and Xiao-Ya Chen. "Systematic identification of functional residues of Artemisia annua amorpha-4,11-diene synthase." Biochemical Journal 474, no. 13 (2017): 2191–202. http://dx.doi.org/10.1042/bcj20170060.

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Terpene synthases (TPSs) are responsible for the extremely diversified and complex structure of terpenoids. Amorpha-4,11-diene synthase (ADS) has a high (90%) fidelity in generating the sesquiterpene precursor for the biosynthesis of artemisinin, an antimalarial drug, however, little is known about how active site residues of ADS are involved in carbocation rearrangement and cyclization reactions. Here, we identify seven residues that are key to most of the catalytic steps in ADS. By structural modeling and amino acid sequence alignments of ADS with two functionally relevant sesquiterpene synt

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Duke, Stephen O., Kevin C. Vaughn, Edward M. Croom, and Hala N. Elsohly. "Artemisinin, a Constituent of Annual Wormwood (Artemisia annua), is a Selective Phytotoxin." Weed Science 35, no. 4 (1987): 499–505. http://dx.doi.org/10.1017/s0043174500060458.

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Artemisinin (qinghaosu), a sesquiterpenoid lactone peroxide constituent of annual wormwood (Artemisia annuaL. # ARTAN) that is used as an antimalarial drug, was tested for phytotoxic properties. It inhibited germination of lettuce (Lactuca sativaL.) and annual wormwood, and growth of roots and shoots of lettuce, redroot pigweed (Amaranthus retroflexusL. # AMARE), pitted morningglory (Ipomoea lacunosaL. # IPOLA), annual wormwood, and common purslane (Portulaca oleraceaL. # POROL) was inhibited at 33 μM. No effects of 33 μM artemisinin were detected on growth of velvetleaf (Abutilon theophrastiM

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Adams, Michael, Stefanie Zimmermann, Marcel Kaiser, Reto Brun, and Matthias Hamburger. "A Protocol for HPLC-based Activity Profiling for Natural Products with Activities against Tropical Parasites." Natural Product Communications 4, no. 10 (2009): 1934578X0900401. http://dx.doi.org/10.1177/1934578x0900401013.

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HPLC based activity profiling is an effective strategy to accelerate the discovery of new hits and leads from nature. It conveniently combines the superior separation power of HPLC micro scale compound separation with miniaturized biological screening methods, and on-line and off-line spectroscopy (PDA, MSn, HR-MS, NMR) for structure elucidation. We here describe a protocol for the discovery of natural products with antimalarial, antileishmanial and antitrypanosomal activity, from extracts libraries in 96-well format. Analytical gradient HPLC on a 3 × 150 mm column of 350 μg of extract, and co

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Baldino, Lucia, Ernesto Reverchon, and Giovanna Della Porta. "An optimized process for SC-CO 2 extraction of antimalarial compounds from Artemisia annua L." Journal of Supercritical Fluids 128 (October 2017): 89–93. http://dx.doi.org/10.1016/j.supflu.2017.05.018.

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Misra, L. N., A. Ahmad, R. S. Thakur, H. Lotter, and H. Wagner. "Crystal Structure of Artemisinic Acid: A Possible Biogenetic Precursor of Antimalarial Artemisinin from Artemisia annua." Journal of Natural Products 56, no. 2 (1993): 215–19. http://dx.doi.org/10.1021/np50092a005.

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Avitabile, Elisabetta, Nina Senes, Cristina D’Avino, et al. "The potential antimalarial efficacy of hemocompatible silver nanoparticles from Artemisia species against P. falciparum parasite." PLOS ONE 15, no. 9 (2020): e0238532. http://dx.doi.org/10.1371/journal.pone.0238532.

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