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Journal articles on the topic 'Arthritis of the knee joint'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Garner, Amelia Jane, Reza Saatchi, Oliver Ward, Harriet Nwaizu, and Daniel Philip Hawley. "Proof-of-Concept Study of the Use of Accelerometry to Quantify Knee Joint Movement and Assist with the Diagnosis of Juvenile Idiopathic Arthritis." Technologies 10, no. 4 (2022): 76. http://dx.doi.org/10.3390/technologies10040076.

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Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. Seven children and young people (CYP) with a diagnosis of JIA and suspected active arthritis of a single knee joint were recruited for this proof-of-concept study. The presence of active arthritis was confirmed by clinical examination. Four tri-axial accelerometers were integrated individually in elastic bands and placed above and below each knee. Participants performed ten periodic flexion-extensions of each knee joint while lying down, followed by walking ten meters in a straight path. The contralateral (n

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Clement, Rhys G. E., Seng J. Wong, Andrew Hall, Sarah E. M. Howie, and A. H. R. W. Simpson. "The long-term time course of septic arthritis." Bone & Joint Open 5, no. 9 (2024): 785–92. http://dx.doi.org/10.1302/2633-1462.59.bjo-2024-0048.r1.

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AimsThe aims of this study were to: 1) report on a cohort of skeletally mature patients with native hip and knee septic arthritis over a 14-year period; 2) to determine the rate of joint failure in patients who had experienced an episode of hip or knee septic arthritis; and 3) to assess the outcome following septic arthritis relative to the infecting organism, whether those patients infected by Staphylococcus aureus would be more likely to have adverse outcomes than those infected by other organisms.MethodsAll microbiological samples from joint aspirations between March 2000 and December 2014

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Otani, K., I. Nita, W. Macaulay, H. I. Georgescu, P. D. Robbins, and C. H. Evans. "Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy." Journal of Immunology 156, no. 9 (1996): 3558–62. http://dx.doi.org/10.4049/jimmunol.156.9.3558.

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Abstract Gene therapy offers a novel approach to treating human joint diseases such as rheumatoid arthritis. In the present study, we have used the retrovirus, MFG-IRAP, to transfer the human IL-1 receptor antagonist protein (IRAP) gene to rabbits' knees and have assessed its impact on inflammatory and chondrodestructive aspects of the acute phase of antigen-induced arthritis in these joints. Surprisingly, intra-articular expression of IRAP was three- to fivefold higher in arthritic knees than in nonarthritic knees, accumulating to levels of over 20 ng/knee in the highest expressing joints. Th

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Goess, Christian, Richard McCarthy, Lian Rundell, et al. "Kinetics of knee synovial lavage inflammation in rodent models of collagen induced arthritis. (171.15)." Journal of Immunology 188, no. 1_Supplement (2012): 171.15. http://dx.doi.org/10.4049/jimmunol.188.supp.171.15.

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Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation, swelling, and destruction of joints. In this study we used intra-articular lavage of the knee joint to easily and rapidly assess the kinetics of cellular infiltration and cytokine production within the local joint synovial environment during disease in rodent models of arthritis. In collagen induced arthritis in rats, knees of arthritic animals had increased cellularity composed of neutrophils, monocytes and T cells as well as marked increases in pro-inflammatory cytokines and chemokines including IL-1b,

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Raghu, Harini, Malinda D. Frederick, Alice Jone, Kathryn E. Talmage, Keith W. Kombrinck та Matthew J. Flick. "Plasminogen Mediates Both Positive and Negative Effects on Disease Severity in a Mouse Model of TNFα-Driven Arthritis". Blood 118, № 21 (2011): 854. http://dx.doi.org/10.1182/blood.v118.21.854.854.

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Abstract Abstract 854 Rheumatoid arthritis is a chronic inflammatory disease of joint tissue wherein dysregulated, robust hemostatic system activity is a consistent pathological feature. Increased local expression of fibrinolytic system components (i.e., plasminogen activators) and accumulation of fibrin degradation products within arthritic joints suggest that plasmin(ogen) may directly or indirectly participate in joint tissue inflammatory/degradative processes. To test the hypothesis that plasmin-mediated proteolysis drives local events in arthritis pathogenesis, we examined the effect(s) o

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Yamasaki, Yutaro, Akira Maeyama, Mai Takeuchi, and Takuaki Yamamoto. "Bilateral Snapping Knee in a Patient with Rheumatoid Arthritis Accompanied by Sjögren’s Syndrome – A Case Report." Journal of Orthopaedic Case Reports 14, no. 12 (2024): 18–21. https://doi.org/10.13107/jocr.2024.v14.i12.5002.

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Introduction: We experienced a rare case in which a bilateral snapping knee was caused by rheumatoid arthritis accompanied by Sjögren’s syndrome (SS), and the symptoms were resolved by arthroscopic surgery. Case Report: A 43-year-old Asian male presented at another hospital with finger, shoulder, and knee pain and was diagnosed with rheumatoid arthritis accompanied by SS. Two months later, he developed the snapping phenomenon in both knees and presented at our hospital. The patient was positive for rheumatoid factor, anti-Smith antibody, and anti-SS-A antibody. Arthroscopy revealed a hard scar

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Laskari, Katerina, George Pentazos, Despina Pitsilka, et al. "Joint microwave radiometry for inflammatory arthritis assessment." Rheumatology 59, no. 4 (2019): 839–44. http://dx.doi.org/10.1093/rheumatology/kez373.

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Abstract Objectives Increased in-depth joint temperature measured by the rapid, easy-to-perform microwave radiometry (MWR) method may reflect inflammation, even in the absence of clinical signs. We hypothesized that MWR is useful for RA and spondyloarthritis patients’ assessment. Methods Clinical examination, joint ultrasound and/or MRI and MWR were performed in two independent patient–control cohorts (n = 243). Results Among single RA joints MWR performed best in the knee using ultrasound as reference, with 75% sensitivity–73% specificity for grey-scale synovitis score ⩾2, and 80% sensitivity

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Wayal, Dr Lekha, Dr S. K. Jaiswal, Dr S. B. Jamdhade, and Dr Pradnya Jamdhade. "“A CASE STUDY OF AYURVEDIC MANAGEMENT OF KROSHUTKSHEERSHA WITH SPECIAL REFERENCE TO PSEUDOGOUT”." Sanjeevani Darshan - National Journal of Ayurveda & Yoga 02, no. 03 (2024): 38–44. http://dx.doi.org/10.55552/sdnjay.2024.2305.

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Pseudogout (PG) is an acute arthritis attack that happens when you don't follow a natural diet and lifestyle. It makes it hard to do normal things. Extreme pain and stiffness happen in the joints, mostly in the knees. PG is made when calcium pyrophosphate crystals, a solid calcium salt, break down from bone that has built up in ligaments and joint spaces, mostly in the knee joints. Traditional medicine has a hard time treating PG, so people all over the world are looking for a method that is safe, cheap, and easy to use. The study's goal is to look at how well traditional ayurvedic treatments

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Akhroridin, Zakhridinovich Ismailov, and Shukhratovich Yusupov Jakhongir. "FEATURES OF THE HISTOMORPHOLOGICAL STRUCTURE OF THE INNER SHELL OF THE ARTICULAR CAPSULE OF THE KNEE JOINT ARE NORMAL." Research and implementation 2, no. 5 (2024): 40–43. https://doi.org/10.5281/zenodo.10965418.

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<em>The histomorphological structure of the inner shell of the articular capsule of the knee joint in rheumatoid arthritis is the object of study of this work. The urgency of the problem is due to the high prevalence of rheumatoid arthritis among the population, especially adults. Rheumatoid arthritis affects joints, including the knees, leading to limited movement and disability. It is known that the synovial membrane of the joint capsule plays an important role in metabolic processes and the creation of optimal conditions for joint movement. However, the histomorphological structure of this

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Waterborg, Claire Elisabeth Joyce, Paqui González Través, Anna Zagórska, Greg Lemke, Silke Beermann, and Fons Adrianus van de Loo. "The TAM receptors Axl and Mer play a joint-specific protective role in experimental arthritis." Journal of Immunology 196, no. 1_Supplement (2016): 117.7. http://dx.doi.org/10.4049/jimmunol.196.supp.117.7.

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Abstract Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an unrestrained inflammatory response in synovial joints. One family of tyrosine kinase receptors involved in anti-inflammatory feedback mechanism are Tyro3, Axl and Mer (TAM). The plasma level of the TAM receptor ligand Gas6 is significantly reduced in RA patients suggesting this feedback mechanism is impaired in RA. We investigated the individual role of each TAM receptor in experimental arthritis. Methods The KRN serum transfer model of arthritis was induced by two intraperitoneal injections of

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Vidyarthi, Ashok, and Alokik Gupta. "A PROSPECTIVE STUDY TO EVALUATE EFFECTIVENESS OF KINESIO TAPING IN NON-TRAUMATIC CHRONIC KNEE PAIN." International Journal of Advanced Research 11, no. 04 (2023): 706–14. http://dx.doi.org/10.21474/ijar01/16717.

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Background: Kinesio tape has multiple benefits including decreasing pain, increasing proprioception, increasing quadriceps muscle strength, and improving lymphaticcirculation at the knee joint. To evaluate the effectiveness of kinesiotape innon traumatic chronic knee pain. Material and Methods: Aprospective study was done from august 2020 to January 2022 in nscb medical college jabalpur on 80 patients with patello femoral arthritis of knee joint and early grade medial joint line arthritis of knee joint(kellgenlawrencegrading) in which kinesio tape was applied over knee for 6 days by an orthopa

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Lubberts, Erik, Leo A. B. Joosten, Liduine van den Bersselaar, et al. "Adenoviral Vector-Mediated Overexpression of IL-4 in the Knee Joint of Mice with Collagen-Induced Arthritis Prevents Cartilage Destruction." Journal of Immunology 163, no. 8 (1999): 4546–56. http://dx.doi.org/10.4049/jimmunol.163.8.4546.

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Abstract Rheumatoid arthritis is a chronic inflammatory joint disease, leading to cartilage and bone destruction. In this study, we investigated the effects of local IL-4 application, introduced by a recombinant human type 5 adenovirus vector, in the knee joint of mice with collagen-induced arthritis. One intraarticular injection with an IL-4-expressing virus caused overexpression of IL-4 in the mouse knee joint. Enhanced onset and aggravation of the synovial inflammation were found in the IL-4 group. However, despite ongoing inflammation, histologic analysis showed impressive prevention of ch

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Senthil, Vishnu, and Manish Khanna. "Knee Cartigram - A Prognostic Factor for Joint Replacement." Scholars Academic Journal of Biosciences 11, no. 02 (2023): 60–62. http://dx.doi.org/10.36347/sajb.2023.v11i02.003.

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Knee osteo-arthritis increases the global burden and adds morbidity to the patient. Total knee replacement is on the rise with patients presenting at stage of advanced knee arthritis increasing surgical morbidity on the patient. Knee cartigram, helps to diagnose early cartilage damage with normal knee radiographs. Addressing cartilage loss at an early stage can preserve the innate knee delaying the onset of arthritis and prevent knee replacement.

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McCarthy, Richard, Christian Goess, Lian Rundell, Carolyn Cuff, Honore Prisca, and Long Andrew. "Pain and inflammation coincide in a collagen-induced arthritis model in rats (171.17)." Journal of Immunology 188, no. 1_Supplement (2012): 171.17. http://dx.doi.org/10.4049/jimmunol.188.supp.171.17.

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Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation, swelling and destruction. In patients diagnosed with RA, these symptoms manifest as pain and lead to fatigue, physical impairment and loss of function. This can be modeled pre-clinically using collagen induced arthritis (rat CIA). Historically, increased swelling of the hind paws measured by plethysmography, and inflammation measured by histology in the ankle joints of arthritic rats have been used to evaluate the effects of potential anti-inflammatory therapies. In the present study, we set out to

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Serrano, Daniel Veloz, Samundeeswari Saseendar, Saseendar Shanmugasundaram, Rohan Bidwai, Diego Gómez, and Riccardo D’Ambrosi. "Spontaneous Osteonecrosis of the Knee: State of the Art." Journal of Clinical Medicine 11, no. 23 (2022): 6943. http://dx.doi.org/10.3390/jcm11236943.

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Osteonecrosis is a terrible condition that can cause advanced arthritis in a number of joints, including the knee. The three types of osteonecrosis that can affect the knee are secondary, post-arthroscopic, and spontaneous osteonecrosis of the knee (SPONK). Regardless of osteonecrosis classification, treatment for this condition seeks to prevent further development or postpone the onset of knee end-stage arthritis. Joint arthroplasty is the best course of action whenever there is significant joint surface collapse or there are signs of degenerative arthritis. The non-operative options for trea

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-, Arvind, Gurchetan Singh, Pavan Sudarshan, and Nirjal Nath. "Rare Case of Ochronosis with Fracture of Intracapsular Neck of Femur and Scoliosis: A Case Report." Journal of Orthopaedic Case Reports 13, no. 1 (2023): 18–21. http://dx.doi.org/10.13107/jocr.2023.v13.i01.3498.

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Introduction: Ochronosis is a rare syndrome caused by accumulation of homogentisic acid in connective tissue due to deficiency of enzyme homogentisic acid oxidase. It characterized by blue-black pigmentation connective tissues such as sclera, cartilage of ear, and synovium of joints and it causes destruction of joints cartilage and early arthritis. Urine becomes dark coloured on prolonged standing. Some patient may develop rare cardiac manifestation due to accumulation of homogentisic acid on valves. Case Report: A 56-year-old female admitted with neck of femur fracture after history of fall a

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Shah, Syed, and Daniel Havlichek. "Native joint septic arthritis withVeillonellaspecies." BMJ Case Reports 12, no. 5 (2019): e229953. http://dx.doi.org/10.1136/bcr-2019-229953.

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Septic arthritis usually presents as subacute monoarticular inflammation. Majority of the cases in healthy adults are caused by methicillin-resistantStaphylococcus aureus,streptococciand certain gram-negative organisms, mostly in the setting of extremes of ages, trauma or immunosuppression. This is a case of a healthy adult with a sudden onset of inflammation of the knee joint, being diagnosed with septic arthritis of the left knee withVeillonellasp. growing from the joint aspirate on two successive cultures. The patient was treated with 6 weeks of oral metronidazole and 4 weeks of intravenous

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Brigham, Christopher R., Charles N. Brooks, and James B. Talmage. "Knee Osteoarthritis." Guides Newsletter 10, no. 2 (2005): 1–3. http://dx.doi.org/10.1001/amaguidesnewsletters.2005.marapr01.

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Abstract More than 20 million Americans have osteoarthritis (OA), which affects the knee more often than any other joint and is the most common cause of long-term disability in persons older than 65 years. Knee OA is common, particularly in older patients and especially the obese. Knee injury, depending on the severity and type, can increase the risk of developing and the rate of progression of OA. In assessing impairment for knee OA, the evaluator must obtain a thorough history and physical examination and identify all potential risk factors. To opine that an injury caused OA, the evaluator s

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Girish, Sharma, Tsering Tsering, and Mahajan Shweta. "Knee Joint Osteo Arthritis: Role of Radiofrequency in Managing Pain." Indian Journal of Anesthesia and Analgesia 5, no. 10 (2018): 1631–38. http://dx.doi.org/10.21088/ijaa.2349.8471.51018.8.

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Skoczynska, M., F. Figus, V. Arena, G. Massazza, and A. Iagnocco. "The role of PET in a clinically silent and ultrasound negative synovitis in the course of rheumatoid arthritis - a case report." Reumatismo 73, no. 1 (2021): 64–66. http://dx.doi.org/10.4081/reumatismo.2021.1253.

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We present a case report of a rheumatoid arthritis patient, who underwent a PET scan, which revealed inflammation of multiple joints, which was missed by both physical and ultrasound examinations. A 55-year old woman with a long-term rheumatoid arthritis, who had undergone arthroplasty of the left knee in the past, consulted with the rheumatologist for pain in the left knee. The physical examination revealed signs of inflammation in the left knee and right elbow. The inflammatory parameters were high. Ultrasound showed intraarticular effusion without signs of active synovitis in the left knee.

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Iordache, Sergiu Andrei, Bogdan Şerban, Mihnea Ioan Gabriel Popa, and Adrian Cursaru. "Current review of surgical management options for total knee arthroplasty in the rheumatoid knee." Romanian Journal of Orthopaedic Surgery and Traumatology 4, no. 1 (2021): 38–45. http://dx.doi.org/10.2478/rojost-2021-0007.

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Abstract Rheumatoid arthritis (RA) represents a condition that can erode cartilage and damage joints, leading to inflammation and loss of movement, characterized by inflammatory synovitis. While the widespread use of potent disease-modifying medications has increased opportunities for RA patients, orthopedic surgery and complete joint arthroplasty remain an important option in end-stage joint treatment. The knee is one of the most frequently affected joints in chronic rheumatoid arthritis patients. The severity of RA ranges from a moderate illness to a serious, rapidly progressing, destructive

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W. Ike, Robert. "Washing Out the Septic Knee." JSM Arthritis 5, no. 1 (2023): 1–4. http://dx.doi.org/10.47739/2475-9155.arthritis.1033.

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Abstract Effective drainage of joint purulence is a key component of the management of the septic knee. Methods from arthrocentesis to open arthrotomy and arthroscopy are mainstays, with different efficacies and morbidities. Percutaneous tube instillation techniques have been employed since World War I. Methods to effect joint distension and irrigation to mimic what is accomplished at arthroscopy employed over the past 65 years have been honed to a simple bedside technique since the 80s and applied successfully in management of several different arthritides, including septic arthritis. Wider e

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Symes, Michael, Andrea Veljkovic, Murray Penner, Alastair Younger, Alastair Younger, and Kevin Wing. "The Other Adjacent Joint." Foot & Ankle Orthopaedics 3, no. 3 (2018): 2473011418S0012. http://dx.doi.org/10.1177/2473011418s00122.

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Category: Ankle Arthritis Introduction/Purpose: Accepted surgical treatment options for end-stage ankle arthritis include total ankle arthroplasty (TAA) and ankle arthrodesis (AA). Although they have comparable clinical outcomes, TAA is growing in popularity and one reason for this is that TAA, compared to AA, better preserves range of motion and function at the ankle, and results in a gait pattern that more closely replicates normal controls. This has the theoretical benefit of protecting adjacent articulations and thereby limiting degenerative changes from occurring in other joints. Although

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Mine, Takatomo, Koichiro Ihara, Hiroyuki Kawamura, Ryutaro Kuriyama, and Ryo Date. "Knee Arthritis Without Other Joint Symptoms in the Elderly With Seronegative Elderly Onset Rheumatoid Arthritis." Open Orthopaedics Journal 10, no. 1 (2016): 793–96. http://dx.doi.org/10.2174/1874325001610010793.

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Elderly onset Rheumatoid arthritis (EORA) has important clinical distinctions when compared with younger onset RA (YORA). In knee arthritis of elderly patients, infection, crystal-induced arthritis or EORA should be suspected if elevation of CRP in the preoperative examination and turbid joint effusion in their knee joint are found. Furthermore, if joint swelling and effusion remain after performing total knee arthroplasty (TKA), the infection after TKA, implant debris-related arthritis and EORA should be considered. However, it is difficult to diagnose patients as EORA if Rheumatoid factor (R

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Mohager, Samah O., Abdelsalam M. Nai, Rayan A. Tonga, Awad H. Abdallah, and Imad M. Fadl-Elmula. "Primary cystic echinococcosis presented as prolonged disabling knee osteoarthritis: a case report." South Sudan Medical Journal 16, no. 1 (2023): 24–27. http://dx.doi.org/10.4314/ssmj.v16i1.6.

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Cystic echinococcosis (hydatid disease) is a neglected tropical disease common in Asia, South America and Sub-Saharan Africa. It is a parasitic disease caused by larval stage of Echinococcus granulosus. The commonest organs affected by hydatidosis are the liver and the lung. Primary bone hydatidosis in humans is a rare disease accounting for 1–2% of echinococcosis cases. To our knowledge secondary hydatidosis of joints is uncommon and few cases of hydatid disease of the knee joint have been reported. We present a case of primary cystic echinococcosis of the knee joint occurring in a 43-year-ol

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Kang, Kyu Bok, Jae Hee Lee, and Jung-Ro Yoon. "Patellofemoral joint disorders." Journal of the Korean Medical Association 66, no. 8 (2023): 464–69. http://dx.doi.org/10.5124/jkma.2023.66.8.464.

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Background: Patellofemoral joint problems refer to a spectrum of conditions affecting the patellofemoral joint, which is the joint between the patella and femur. These conditions can cause pain and instability in the knee and affect an individual’s ability to perform daily activities. Patellofemoral joint problems commonly cause knee pain, particularly among young athletes and physically active individuals. This review article discusses current patellofemoral joint problems, including their epidemiology, pathophysiology, diagnosis, and management.Current Concepts: Patellofemoral joint problems

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Dhawadkar, Dr Prajakta, Dr Subhash Jamdhade, Dr Yogesh Duddalwar, and Dr Pradnya Jamdhade. "THE ROLE OF AYURVEDIC MANAGEMENT IN KROSHUTKSHIRSHA W.S.R. TO INFECTIVE ARTHRITIS – A CASE STUDY." Sanjeevani Darshan - National Journal of Ayurveda & Yoga 02, no. 01 (2024): 126–32. http://dx.doi.org/10.55552/sdnjay.2024.2116.

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Septic arthritis is a painful joint infection that can be caused by an infection. Septic arthritis is also known as infectious arthritis. In Ayurveda it can be associated with Kroshutkshirsha. Kroshutkshirsha is one of the natmaj vatavyadhi characterized by swelling and pain in the knee joint. A 50-year-old patient applied to the Kaychikit department of the clinic complaining of severe pain, swelling and redness above the knee joint. Diagnosis: Kroshutkshirsha. He was shifted to a closed ward and received Ayurvedic treatment for seven days. The overall swelling and redness of the patient's lef

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Trotsenko, V. V. "Two-steps surgical restoration of the function of ankylosing knee joint in rheumatoid arthritis." N.N. Priorov Journal of Traumatology and Orthopedics 2, no. 1-2 (1995): 26–31. http://dx.doi.org/10.17816/vto99579.

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Two-steps restoration of knee joint function enables first to eliminate the flexion deformity by mobilization and then gradually to elongate the posterior anatomic structures of fibrous ankylosing knee joint. For the management the hinged distraction apparatus is used. In bone flexion ankylosis of the knee joint the osteotomy is performed along the line of the union of femur with the patella and tibia followed by gradual extension of the knee joint using hinged distraction apparatus. During the second step of the surgery the restoration of the whole synovial space of the knee joint including t

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Patel, Vatsal Bharatkumar, Sanjay V. Deshpande, Vivek Jadawala, Disheeta Bhalsod, Rushi Jadawala, and Siddharth Patel. "A rare case of triple deformity of knee secondary to Garre’s osteomyelitis." Multidisciplinary Science Journal 7, no. 10 (2025): 2025459. https://doi.org/10.31893/multiscience.2025459.

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Septic arthritis can lead to joint damage and severe deformities if not treated on time. Garre’s osteomyelitis is a chronic osteomyelitis commonly observed in young adults and children in the mandible region and rarely observed in long bones. Clinical symptoms might include localized pain which is gradually progressive. A triple knee joint deformity results from such neglected infection, causing flexion, adduction and internal rotation deformity. This deformity can affect the range of motion of joints and thus affect the patient's quality of life. This is a case of a 36-year-old female with a

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Oishi, Yukiyoshi, Yuji Hirano, Yukiharu Hasegawa, Kenichi Yamauchi, Yasuhide Kanayama, and Susumu Ota. "PRIOR KNEE OSTEOPOROSIS ASSOCIATING THE 10-YEAR CLINICAL OUTCOME OF TOTAL KNEE ARTHROPLASTY FOR RHEUMATOID ARTHRITIS: A RETROSPECTIVE STUDY." Journal of Musculoskeletal Research 20, no. 02 (2017): 1750007. http://dx.doi.org/10.1142/s0218957717500075.

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The aim of this retrospective study was to determine whether prior regional osteoporosis in the knee associates the 10-year outcome of total knee arthroplasty (TKA) in patients with rheumatoid arthritis (RA). About 63 knees of 45 RA patients underwent cruciate-retaining Deltafit TKA. Overall, long-term results of the RA disease activity were based on dual-energy X-ray absorptiometry (DXA) to evaluate osteoporosis; the Japanese Orthopedic Association (JOA) functional knee score, a disease activity score of 28 joints; and the neck large joint score 12 for joint destruction, which were investigat

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Lee, Hyeonjeong, Camilla R. L. Machado, Deepa Hammaker, et al. "Joint-specific regulation of homeobox D10 expression in rheumatoid arthritis fibroblast-like synoviocytes." PLOS ONE 19, no. 6 (2024): e0304530. http://dx.doi.org/10.1371/journal.pone.0304530.

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Rheumatoid arthritis (RA) is a systemic immune-mediated disease characterized by joint inflammation and destruction. The disease typically affects small joints in the hands and feet, later progressing to involve larger joints such as the knees, shoulders, and hips. While the reasons for these joint-specific differences are unclear, distinct epigenetic patterns associated with joint location have been reported. In this study, we evaluated the unique epigenetic landscapes of fibroblast-like synoviocytes (FLS) from hip and knee synovium in RA patients, focusing on the expression and regulation of

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Hindle, P., E. Davidson, and LC Biant. "Septic arthritis of the knee: the use and effect of antibiotics prior to diagnostic aspiration." Annals of The Royal College of Surgeons of England 94, no. 5 (2012): 351–55. http://dx.doi.org/10.1308/003588412x13171221591015.

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Septic arthritis of the native knee joint and total knee arthroplasty both cause diagnostic and treatment issues. There is no gold standard test to diagnose a joint infection and the use of joint aspiration is commonly relied on. It is widely accepted by orthopaedic surgeons that antibiotics should be withheld until aspiration has been performed to increase the odds of identifying an organism. Patients often present to other specialties that may not be as familiar with these principles. Our study found that 25 (51%) of the 49 patients treated for septic arthritis of the native or prosthetic kn

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Roberts, John, and Elisabeth Merchant. "Trauma-related Lyme arthritis." BMJ Case Reports 16, no. 7 (2023): e255532. http://dx.doi.org/10.1136/bcr-2023-255532.

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A man in his 40s with no prior orthopaedic history presented to an infectious disease clinic with persistent left knee pain and swelling following a traumatic meniscal tear and ensuing prodromal period of fever and chills. Aspiration of the left knee joint revealed a white cell count of 21.0 ×109/L (83% neutrophils) with negative Gram stain and culture. However, Lyme PCR was positive and accompanied by serologies consistent with Lyme arthritis. He was treated with a standard course of antibiotic therapy with subsequent resolution of joint effusion and significant improvement in pain.This is to

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Fedina, T. P., Yu A. Olyunin, O. V. Pushkov, N. P. Apenysheva, and R. M. Balabanova. "Dynamics of synovitis activity after intraarticular administration of xefocam in patients with rheumatoid arthritis." N.N. Priorov Journal of Traumatology and Orthopedics 9, no. 2 (2022): 78–80. http://dx.doi.org/10.17816/vto99822.

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The aim of the study was to assess the efficacy of intra-articular injection of lornoxicam (xefocam, Nycomed) in patients with rheumatoid arthritis. Xefocam was injected into knee joints of 15 patients with rheumatoid arthritis, 8 mg once a week for the period of 3 weeks. The following parameters were assessed: pronouncement of arthralgia, joint tenderness at palpation, circumference of knee joint on the level of the upper patellar margin. Prior and post treatment ultrasonography and thermography were used. Significant clinical improvement was observed in 11 patients. In 3 cases the dynamics w

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Panjwani, Taufiq, Keng Lin Wong, Si Heng Sharon Tan, Glen Liau, Narendra Vaidya, and Lingaraj Krishna. "Arthroscopic debridement has lower re-operation rates than arthrotomy in the treatment of acute septic arthritis of the knee: a meta-analysis." Journal of ISAKOS: Joint Disorders & Orthopaedic Sports Medicine 4, no. 6 (2019): 307–12. http://dx.doi.org/10.1136/jisakos-2018-000269.

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ImportanceSeptic arthritis of the native knee joint is the most common bacterial joint infection. The management involves prompt surgical debridement and joint irrigation by arthroscopy or arthrotomy. This is the first systematic review and meta-analysis to compare arthroscopic debridement with arthrotomy for septic arthritis of native knee joint.ObjectiveThe purpose of this systematic review and meta-analysis is to compare re-operation rates, length of inpatient hospital stay (LOS) and functional outcome between arthroscopy and arthrotomy in the treatment of acute septic arthritis of the nati

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Rosenbaum, Dov, Arthur B. Meyers, Patricia Vega-Fernandez, Samuel Sisay Hailu, Carlos Yaya-Quezada, and Jie C. Nguyen. "Juvenile Idiopathic Arthritis and Spondylarthritis." Seminars in Musculoskeletal Radiology 29, no. 02 (2025): 249–66. https://doi.org/10.1055/s-0045-1802652.

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AbstractJuvenile idiopathic arthritis (JIA) is a heterogeneous disorder affecting children < 16 years of age. The clinical heterogeneity translates to imaging, where no specific joint is affected. This article highlights a general imaging approach to JIA, using specific examples of the knee, hand, and wrist as the typical joints affected. We then focus on unique joints that are commonly affected by JIA: the temporomandibular joint, the joints of the upper cervical spine, and the sacroiliac joint. For these latter anatomical sites, regional anatomy and development, location-specific imaging

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Senarathna, H., and K. Deshapriya. "Delayed Diagnosis: Tuberculous Arthritis of Right Knee Joint in a Patient with Rheumatoid Arthritis." Case Reports in Rheumatology 2021 (December 26, 2021): 1–4. http://dx.doi.org/10.1155/2021/7751509.

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Background. Though skeletal tuberculosis (TB) accounts about 3% of all TB cases, it occupies 10–35% of extrapulmonary TB cases. Common osteoarticular sites involved include the spine (40%), hip (25%), and knee (8%). Co-occurrence of rheumatoid arthritis (RA) and tuberculous arthritis involving peripheral joint is rarely reported in the literature. Case Presentation. We present a case of 42-year-old Sri Lankan-Sinhalese male with right knee joint pain and swelling for one-year duration. This patient had a history of long-standing RA with interstitial lung disease for which he was on multiple im

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Hsieh, Yi-Ho, Yi-Chieh Chu, Jui-Ting Hsiao, Yi-Ting Shu, Ming-Fa Hsieh, and Hung-Maan Lee. "Porcine Platelet Lysate Intra-articular Knee Joint Injections for the Treatment of Rabbit Cartilage Lesions and Osteoarthritis." Journal of Medical and Biological Engineering 43, no. 1 (2023): 102–11. http://dx.doi.org/10.1007/s40846-023-00776-1.

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Abstract Purpose At present, autologous platelet-derived therapies such as platelet-rich plasma is widely used in the clinic, but allogeneic and xenogeneic therapies are currently in the research stage, mainly due to their biocompatibility in vivo. Platelet lysates depleted of antigens such as blood cells are a potential solution for allogeneic or xenogeneic applications. Platelet lysates can successfully promote the growth and differentiation of xenogeneic cells in vitro, but in vivo data are not yet available. This study aims to evaluate whether porcine platelet lysate can effectively avoid

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Samant, Vinay. "Coronal Plane Alignment of Knee Joint (C.P.A.K.) Classification in Indian Population- Study of A New Classification System in Indian Knees." Journal of Orthopedics & Bone Disorders 7, no. 4 (2023): 1–8. http://dx.doi.org/10.23880/jobd-16000250.

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Background: Distribution of CPAK types in Indian knees will help surgeons better understand management of knee arthritis using concept of Kinematic alignment (K.A.). C.P.A.K. uses a matrix of 9 phenotypes of knees based on arithmetic hip knee ankle angle (aHKA) and Joint Line Obliquity (JLO). Methods: A radiological analysis of 200 healthy knees (HC) and 250 osteoarthritic knees (OC) was done and were classified based on C.P.A.K. classification. Primary outcomes include descriptive analysis of both groups, and comparison between frequencies of types within each group. Results: The commonest CP

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Khodaee, Morteza, Lindsay Ogle, and Cleveland Piggott. "Unilateral knee effusion in an elderly patient: an unusual presentation of rheumatoid arthritis." Journal of Primary Health Care 12, no. 4 (2020): 391. http://dx.doi.org/10.1071/hc20035.

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ABSTRACT Unilateral atraumatic knee effusion is a relatively common presenting complaint among geriatric patients in primary care and musculoskeletal speciality clinics. Gout, pseudogout, degenerative joint diseases and reactive arthritis are the most common causes of the atraumatic knee effusions. Rheumatoid arthritis very rarely presents as arthritis of one or two large joints. Arthrocentesis, plain radiography and screening blood tests should be performed to help narrow the differential diagnosis. In some cases, advanced imaging modalities such as MRI may be indicated. This study reports a

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Sculco, Thomas P. "THE KNEE JOINT IN RHEUMATOID ARTHRITIS." Rheumatic Disease Clinics of North America 24, no. 1 (1998): 143–56. http://dx.doi.org/10.1016/s0889-857x(05)70382-3.

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Sculco, Thomas P., Paul Lombardi, and Alexander Miric. "The knee joint in rheumatoid arthritis." Comprehensive Therapy 26, no. 2 (2000): 127–33. http://dx.doi.org/10.1007/s12019-000-0023-8.

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Xo’janazarov Ilxom Eshqulovich, Axmedov Xalmurad Sa’dullayevich, and Anorboyev Ma’ruf Xolbo’ta o’g’li. "Knee joint endoprosthetics for rheumatoid arthritis." Texas Journal of Medical Science 39 (December 6, 2024): 5–6. https://doi.org/10.62480/tjms.2024.vol39.pp5-6.

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Lv, Xinyu, Na Ta, Tao Chen, Jing Zhao, and Haicheng Wei. "Analysis of Gait Characteristics of Patients with Knee Arthritis Based on Human Posture Estimation." BioMed Research International 2022 (April 14, 2022): 1–8. http://dx.doi.org/10.1155/2022/7020804.

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A gait feature analysis method based on AlphaPose human pose estimation fused with sample entropy is proposed to address complicated, high-cost, and time-consuming postoperative rehabilitation of patients with joint diseases. First, TensorRT was used to optimize the inference of AlphaPose, which consists of the target detection algorithm YOLOv3 and the pose estimation algorithm. It can speed up latency and throughput by about 2.5 times while maintaining the algorithm’s accuracy. Second, the optimized human posture estimation algorithm AlphaPose_trt was used to process gait videos of healthy pe

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Bhaskaran, Sinukumar, and Lalkar Laxman Gadod. "Post-traumatic Arthritic Stiff Knee in a Malunited Distal Femur Fracture Treated with Total Knee Arthroplasty – A Case Report." Journal of Orthopaedic Case Reports 12, no. 8 (2022): 85–88. http://dx.doi.org/10.13107/jocr.2022.v12.i08.2976.

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Introduction: : Post-traumatic knee arthritis is defined as any structural osteochondral damage to the knee after an injury. About 12% cases of symptomatic osteoarthritis of the knee mainly due to post-traumatic arthritis. Primary total knee arthroplasty in a post-traumatic arthritic stiff knee with a malunited distal femur fracture is a technically difficult procedure due to secondary deformity, poor bone quality, bone loss, ligament incompetence, tissue adhesion, and stiffness. Case Report: A 65-year-old male presented with chief complaints of pain and stiffness in the left knee for 15 years

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JANOW, GINGER L., VIKASH PANGHAAL, ANGELA TRINH, DAVID BADGER, TERRY L. LEVIN, and NORMAN T. ILOWITE. "Detection of Active Disease in Juvenile Idiopathic Arthritis: Sensitivity and Specificity of the Physical Examination vs Ultrasound." Journal of Rheumatology 38, no. 12 (2011): 2671–74. http://dx.doi.org/10.3899/jrheum.110360.

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Objective.To determine sensitivity and specificity of the physical examination (PE) for identifying synovitis in the knee and ankle joints of children with juvenile idiopathic arthritis (JIA), and to identify cases in which ultrasound (US) screening augments the PE.Methods.Nineteen patients with JIA were referred for US. Both knees and ankles were examined using US with and without power Doppler. Active arthritis on PE was defined as (1) non-bony swelling or (2) limitation of motion with either pain on motion or tenderness to palpation. Active arthritis on US was defined as synovial hyperplasi

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Herasymenko, Sergiy, Myhailo Poluliakh, Andriy Babko, et al. "The knee joint deformities in rheumatoid arthritis patients." ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS, no. 3-4 (May 26, 2023): 22–28. http://dx.doi.org/10.15674/0030-598720223-422-28.

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Knee joints injury in rheumatoid arthritis patients appear in 70 % cases. This is the most common cause of loss of work capacity, the ability to self-care. Patients become severely disabled, in that the disease is accompanied by deformations with the development of discordant positions of the lower limbs, which lead to a partial or complete loss of the function of support and walking, so this problem needs to be studied. Objective. To make an analysis of orthopedic treatment of secondary arthrosis of knee joints in RA patients, complicated by deformities depending on the age and gender of the

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Bespalova, Vladyslava, and Liubov Petelytska. "Hypertrophy of the synovial membrane with the background of juvenile idiopathic arthritis under the mask of tenosynovial giant cell tumour: a clinical case report." Ukrainian Scientific Medical Youth Journal 154, no. 2 (2025): 83–90. https://doi.org/10.32345/usmyj.2(154).2025.83-90.

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juvenile idiopathic arthritis is the most common childhood rheumatologic disorder, characterized by chronic inflammation in the synovial joints. Its pathophysiology includes synoviocyte proliferation, pathological angiogenesis, and immune cell infiltration, leading to joint destruction and functional impairment. Tenosynovial giant cell tumor, a rare benign tumor affecting synovial tissues, often mimics juvenile idiopathic arthritis symptoms, complicating diagnosis. This case presents a 30-year-old male with a long history of juvenile idiopathic arthritis and recurrent uveitis, who was diagnose

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Febrianto, Dicky, and Awalia Awalia. "Diagnostic Problem in a Patient with Tuberculosis Arthritis." Current Internal Medicine Research and Practice Surabaya Journal 4, no. 1 (2023): 23–29. http://dx.doi.org/10.20473/cimrj.v4i1.42289.

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Extra-pulmonary tuberculosis (TB) remains a big public health problem worldwide. Although TB most commonly affects the lungs, any organ or tissue can be involved. TB arthritis is a rare form of extra-pulmonary TB. TB arthritis usually manifests as mild and non-specific arthritis. A 35-year-old male was admitted to the emergency room of Dr. Soetomo General Academic Hospital Surabaya due to pain of left knee since two days prior to admission. His symptom began on previous six months with the swelling of the left knee that gradually worsened so that he had an antalgic gait. Radiological examinati

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Lin, Yu-Hsing, Chia-Chi Chen, and Hsiao-Yun Chen. "Establishment of a Surgery-Induced Osteoarthritis Rat Model." Journal of Biomedical Engineering and Medical Imaging 9, no. 1 (2022): 1–15. http://dx.doi.org/10.14738/jbemi.91.11572.

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The degenerative arthritis has been a common knee joint disease in Taiwan. In mild cases of degenerative arthritis, it may just be a little uncomfortable to walk, but severe degenerative arthritis will cause difficulty in walking and even loss of basic mobility. The loss of articular cartilage in degenerative arthritis is irrecoverable. Currently, the degeneration of the knee joint can be easily divided into three levels based on its severity: primary, intermediate, and severe. The choice of treatments for degenerative arthritis will vary in according to different levels that is mainly divided

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