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Relevant bibliographies by topics / ARTIFICIAL CELL, NMR, PROTEIN, FABP

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Journal articles
Dissertations / Theses

Academic literature on the topic 'ARTIFICIAL CELL, NMR, PROTEIN, FABP'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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Journal articles on the topic "ARTIFICIAL CELL, NMR, PROTEIN, FABP"

1

GUTIÉRREZ-GONZÁLEZ, Luis H., Christian LUDWIG, Carsten HOHOFF, et al. "Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP)." Biochemical Journal 364, no. 3 (2002): 725–37. http://dx.doi.org/10.1042/bj20020039.

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Human epidermal-type fatty acid-binding protein (E-FABP) belongs to a family of intracellular 14–15kDa lipid-binding proteins, whose functions have been associated with fatty acid signalling, cell growth, regulation and differentiation. As a contribution to understanding the structure—function relationship, we report in the present study features of its solution structure and backbone dynamics determined by NMR spectroscopy. Applying multi-dimensional high-resolution NMR techniques on unlabelled and 15N-enriched recombinant human E-FABP, the 1H and 15N resonance assignments were completed. On

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Hayakawa, Satoshi, Toshiisa Konishi, Tomohiko Yoshioka, Eiji Fujii, and Kouji Kawabata. "NMR Structural Characterization of Mg-Containing Nano-Apatite." Key Engineering Materials 631 (November 2014): 57–60. http://dx.doi.org/10.4028/www.scientific.net/kem.631.57.

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Nanometer scale Ca-deficient hydroxyapatite (nanoapatite) is a potential candidate as artificial bone substitute materials owing to its similarity to the bone with respect to composition, morphology and osteoclastic degradation or adsorbent materials for blood purification therapy to remove pathogenic substances. The initial biodegradation behaviors, the initial cell-material interaction and the protein adsorption properties of nanoapatite must depend on the microstructure. The purpose of this study is the preparation of nanoapatite particles and their structural characterization by using X-ra

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3

Juskewitz, Eric, Ekaterina Mishchenko, Vishesh K. Dubey, et al. "Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus." Marine Drugs 20, no. 5 (2022): 277. http://dx.doi.org/10.3390/md20050277.

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Treatment options for infections caused by antimicrobial-resistant bacteria are rendered ineffective, and drug alternatives are needed—either from new chemical classes or drugs with new modes of action. Historically, natural products have been important contributors to drug discovery. In a recent study, the dimeric naphthopyrone lulworthinone produced by an obligate marine fungus in the family Lulworthiaceae was discovered. The observed potent antibacterial activity against Gram-positive bacteria, including several clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates, prompted

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Mahi Imad, El Azraky Yassir, El Moujtahide Dounia, Sebbar El Houcine, and Choukri Mohammed. "Metabolomics and oxidative stress assessment in diabetic patients." International Journal of Science and Research Archive 14, no. 3 (2025): 1623–28. https://doi.org/10.30574/ijsra.2025.14.3.0901.

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Metabolomics has emerged as a powerful tool in biomedical research, offering comprehensive insights into metabolic alterations associated with various diseases, including diabetes. One of the key aspects of diabetes pathophysiology is oxidative stress, which results from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms. This imbalance contributes significantly to insulin resistance, β-cell dysfunction, and the progression of microvascular and macrovascular complications. This review explores the integration of metabolomics in assessing oxidative

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Fairfield, Heather, Haylee Duval, Kaitlyn Belknap, et al. "Multiple Myeloma Progression Is Accelerated By Microenvironmental-Derived Fatty Acid Binding Proteins 4 and 5 (FABP4/FABP5) in a Murine Model." Blood 144, Supplement 1 (2024): 667. https://doi.org/10.1182/blood-2024-208066.

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Multiple myeloma (MM) is an incurable cancer of monoclonal plasma cells that largely accumulate within bone marrow (BM) with high rates of patient relapse. The fatty acid binding proteins (FABPs) are a family of ten proteins which serve as metabolic-modulating molecules and fatty acid transporters. We previously found associations between myeloma outcomes and higher tumor cell expression of FABP5 and FABP6. Herein, we interrogated the role of microenvironmentally-derived FABPs in MM progression. First, a novel strain of mice containing a double knockout of Fabp4/FABP4 and Fabp5/FABP5 were purc

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Assante, G., A. Tourna, R. Carpani, et al. "Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell death." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-23282-x.

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AbstractThe gut is of importance in the pathology of COVID-19 both as a route of infection, and gut dysfunction influencing the severity of disease. Systemic changes caused by SARS-CoV-2 gut infection include alterations in circulating levels of metabolites, nutrients and microbial products which alter immune and inflammatory responses. Circulating plasma markers for gut inflammation and damage such as zonulin, lipopolysaccharide and β-glycan increase in plasma along with severity of disease. However, Intestinal Fatty Acid Binding Protein / Fatty Acid Binding Protein 2 (I-FABP/FABP2), a widely

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Pujals, Silvia. "Curvature Engineering: Positive Membrane Curvature Induced by Epsin N‑Terminal Peptide Boosts Internalization of Octaarginine." July 5, 2013. https://doi.org/10.5281/zenodo.10641305.

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Epsin-1 is a representative protein for inducing the positive curvature necessary for the formation of clathrin-coated pits. Here we demonstrate that the N-terminus 18-residue peptide of epsin-1 (EpN18) has this ability per se, as proved by differential scanning calorimetry (DSC) and solid state NMR. Moreover, it is shown how this positive curvature promotion can be exploited for promoting the direct penetration of a representative cell-penetrating peptide (CPP), octaarginine (R8), through artificial and plasma membranes. This synergistic effect has been used for the efficient delivery of

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8

Heravi, Sina, Jude Vincent Dobbin Power, Anand Yethiraj та Valerie Booth. "The effects of biological crowders on fibrillization, structure, diffusion, and conformational dynamics of α‐synuclein". Protein Science 33, № 3 (2024). http://dx.doi.org/10.1002/pro.4894.

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Abstractα‐synuclein is an intrinsically disordered protein (IDP) whose aggregation in presynaptic neuronal cells is a pathological hallmark of Lewy body formation and Parkinson's disease. This aggregation process is likely affected by the crowded macromolecular cellular environment. In this study, α‐synuclein was studied in the presence of both a synthetic crowder, Ficoll70, and a biological crowder composed of lysed cells that better mimics the biocomplexity of the cellular environment. 15N‐1H HSQC NMR results show similar α‐synuclein chemical shifts in non‐crowded and all crowded conditions

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Kogut‐Günthel, Małgorzata M., Zeenat Zara, Alessandro Nicoli, et al. "The path to the G protein‐coupled receptor structural landscape: Major milestones and future directions." British Journal of Pharmacology, August 29, 2024. http://dx.doi.org/10.1111/bph.17314.

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G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets. Advancements in structural biology techniques, including X‐ray crystallography and cryo‐electron microscopy (cryo‐EM), have driven the elucidation of an increasing number of GPCR structures. These structures reveal novel features that shed light on receptor activation, dimerization a

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Gurruchaga-Pereda, J., V. Martinez-Martinez, E. Rezabal, et al. "Flavin Bioorthogonal Photocatalysis Towards Platinum Substrates." ACS Catalysis, November 19, 2019. https://doi.org/10.1021/acscatal.9b02863.

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Catalytic reactions that use metal complexes as substrates, rather than catalysts, are nearly unknown. We recently demonstrated that certain flavins (FLs) are potent redox photocatalysts capable of converting Pt<sup>IV</sup> anticancer prodrug complexes into Pt<sup>II</sup> drugs in the biological environment. Herein, we investigate the mechanism of these artificial photocatalytic reactions employing four different free flavins, namely riboflavin (Rf), flavin mononucleotide (FMN), tetra-O-acetyl riboflavin (TARF) and lumiflavin (Lf), and the flavoprotein miniSOG (mini Singlet Oxygen Generator)

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Dissertations / Theses on the topic "ARTIFICIAL CELL, NMR, PROTEIN, FABP"

1

Perez, Santero Silvia. "Artificial Cells and Cell Mimics: Applications in Synthetic Biology and Biomolecular NMR Spectroscopy." Doctoral thesis, 2016. http://hdl.handle.net/11562/939282.

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La biologia sintetica di solito sviluppa il disegno cellulare utilizzando strategie "bottom-up", dal basso verso l’alto, inserendo e/o cancellando geni provenienti da organismi esistenti. Invece, gli approcci "top-down", dall’alto verso il basso, potrebbero consentire il controllo di cellule viventi in un modo che non richiede manipolazione genetica diretta. Ad esempio, le cellule artificiali (cellule costruite in laboratorio, ovvero, cellule sintetiche che mimano le cellule naturali), possono essere utilizzate per "tradurre" segnali esterni che le cellule naturali possono "comprendere" senza

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