Dissertations / Theses on the topic 'Artificiali'
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Baldacci, Francesco. "Sostituenti sanguigni artificiali." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7346/.
Full textMonaldi, Jessica. "neuroni artificiali e loro applicazioni." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21371/.
Full textLasagni, Nicola. "Reti neuronali artificiali e composizione musicale." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9615/.
Full textCastrignano, Paola. "Modularità: Dai sistemi biologici ai sistemi artificiali." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7072/.
Full textCielo, Michele. "Rilevamento di malattie oculari mediante reti neurali artificiali." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19750/.
Full textCiliegi, Federico. "Topologie non convenzionali per reti di neuroni artificiali." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19497/.
Full textBernardini, Alberto. "Classificazione di brani musicali mediante reti neuronali artificiali." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3408/.
Full textMoruzzi, Letizia. "Risposta del Meiobenthos all'input di detrito da barriere artificiali." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amslaurea.unibo.it/1419/.
Full textDe, Paoli Davide. "Reti neurali artificiali e apprendimenti basati sulla biofisica dei neuroni." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/22983/.
Full textBaronti, Mattia. "Identificazione e localizzazione del danno in strutture reticolari mediante modi di vibrare e reti neurali artificiali." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
Find full textLanzafame, Concetta. "Valutazione della qualità degli ambienti lagunari: confronto tra popolamenti bentonici residenti e reclutamento su pannelli artificiali." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/4595/.
Full textBevini, Giorgia. "Studio di un pilota automatico per aereo basato su Artificial Neural Network." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020.
Find full textMarighetti, Stefano. "Studio idrogeologico del settore nord orientale dell’Altopiano carsico dei Sette Comuni (Asiago) con traccianti naturali ed artificiali." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14437/.
Full textRicci, Elena. "Analisi dei piani di gestione degli invasi ENEL Northern Central Area e approfondimento del caso di studio del lago di Quarto." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
Find full textBalugani, Sofia. "Caratterizzazione del voltaggio di circuito aperto su scala nanometrica di un’etero-giunzione organica per impianti di retina artificiali." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16958/.
Full textDonati, Rebecca. "Introduzione alle lingue artificiali di J.R.R Tolkien. Quenya: il "Cancello di Moria" delle lingue della Terra di Mezzo." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21310/.
Full textCichetti, Federico. "Activity Recognition e Captioning da Video con Deep Learning: Analisi Comparativa dello Stato dell'Arte mediante Nuovi Video Set Artificiali." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20368/.
Full textNeretti, Ugo <1975>. "Influenza delle caratteristiche quali-quantitative della luce da fonti artificiali sulla fisio-morfologia di piante verdi per interior landscaping." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1714/.
Full textSighinolfi, Luca. "Valutazione e miglioramento delle caratteristiche biologiche e biochimiche di insetti predatori allevati su diete artificiali per un loro utilizzo in lotta biologica." Lyon, INSA, 2005. http://www.theses.fr/2005ISAL0026.
Full textHarmonia axyridis is a coccinellid predator of aphids that can be reared in large numbers with Ephestia kuehniella eggs a a substitution prey. The mass production of this coccinellid for use in biocontrol strategies could be mainly enhanced by the availability of an artificial food less expensive, more efficient, and more flexible to use than E. Kuehniella eggs. Artificial foods were tested and improved with an analytical approach and successive iterations by comparing the biochemical composition of the ladybeetles bred on the diets vs. Those fed on E. Kuehniella eggs. All the artificial food tested allowed the development of H. Axyridis from first instar larva to adult. Moreover, the females fed throughout their whole life with two of the diets tested laid fertile eggs, although in a lower number compared to the control ones. The changes made to the composition of the diet, or its physical aspect resulted in the improvernent of bath biological and biochemical parameters. Due to their low cast and simple preparation, artificial diets may become a valid "alternative food" for H. Axyridis in replacement of E. Kuehniella eggs. The quality control of H. Axyridis produced on artificial food is very important, because the objective of the breeding on this food is not only to obtain high yields in larvae an adult, but also to obtain insects having potentialities which satisfy the objectives for which they were produced, especially predation efficiency. Certain biological or biochemical characteristics could provide criteria of appreciation of this quality
Covato, Gaia. "Variabilità dei popolamenti epibentonici della riviera del Conero." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017.
Find full textTosi, Luca. "Analisi di dati telerilevati per la stima del fabbisogno irriguo e del suo soddisfacimento tramite invasi artificiali: casi studio nel Consorzio della Romagna Occidentale." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017.
Find full textGualandi, Giacomo. "Analisi di dataset in campo finanziario mediante reti neurali LSTM." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19623/.
Full textBarbazza, Sigfrido. "Deep-learning applicato all'identificazione automatica di frutta in immagini." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/11526/.
Full textScarpellini, Alberto. "Metodologie avanzate per l'analisi delle performance di un impianto eolico." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15191/.
Full textVenturi, Alberto. "Implementazione di un sistema intelligente per la modellazione di processo con un'applicazione alla pressofusione." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
Find full textBonfiglioli, Luca. "Identificazione efficiente di reti neurali sparse basata sulla Lottery Ticket Hypothesis." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020.
Find full textCastellazzi, Nicolò. "Analisi di immagini per l'identificazione automatica di anomalie superficiali in ambito industriale." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020.
Find full textLoula, Angelo Conrado. "Comunicação simbolica entre criaturas artificiais : um experimento em vida artificial." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/259783.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Eletrica e de Computação
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Mestrado
Engenharia de Computação
Titulação
Fiorello, Gloria. "Una lingua per l'Europa: possibili alternative al multilinguismo." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8818/.
Full textRoberti, Michele. "Sistemi esperti: Mycin come caso di studio." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8358/.
Full textGuahyba, Adriano da Silva. "Utilização de inteligência artificial (redes neurais artificiais) no gerenciamento de reprodutoras pesadas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2001. http://hdl.handle.net/10183/3322.
Full textLavista, Andrea. "Natural language processing: chatbot per gli studenti del Campus di Cesena." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19555/.
Full textZucchi, Lorenzo. "Fenomeni visivi durante movimenti oculari saccadici: studio mediante modello di rete neurale." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/17918/.
Full textMartinelli, Margherita. "Il Dothraki." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18343/.
Full textCastrillejo, Iridoy Maxi. "Sources and distribution of artificial radionuclides in the oceans: from Fukushima to the Mediterranean sea." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/457438.
Full textThis PhD dissertation aimed to understand the sources and distributions of a diverse set of artificial radionuclides (90Sr, 129I, 134Cs, 137Cs, 236U, 237Np, 239Pu and 240Pu) in two contrasting oceanic regions. Firstly, the Pacific Ocean close to Japan, largely impacted by the accident that occurred at the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) in 2011, which led to the release of radioactive contaminants to the environment immediately after the accident and during the following years. We focused on 90Sr, which was largely understudied despite being of major concern due to its large presence in cooling waters stored in tanks and in the nuclear facility since 2011. We collected seawater, groundwater and surface beach water samples between 0.8 and ~100 km off FDNPP in September 2013, two and a half years after the accident. In this work we also evaluated the temporal evolution of 134Cs, 137Cs and 90Sr concentrations, highlighting the relative importance of various sources in the coast off Japan over time.The radionuclide concentrations in water samples collected in September 2013 were up to 8.9 ± 0.4 Bq·m-3 for 90Sr, 124 ± 3 Bq·m-3 for 137Cs and 54 ± 1 Bq·m-3 for 134Cs in 2013, while their typical concentrations prior to the 2011 accident due to the nuclear tests were ~1 Bq·m-3, 1-2 Bq·m-3 and neglible, respectively. This confirmed the ongoing 90Sr releases from the FDNPP, that we estimated in 2.3-8.5 GB·d-1 in September 2013. Although substantially lower than the rates estimated to have occurred soon after the accident, the continuing releases and the potential larger leaks from the FDNPP evidenced the importance of continuous surveillance of artificial radionuclides in the Pacific Ocean. Secondly, the semi-enclosed Mediterranean Sea, impacted by various sources since the mid-twentieth century: i) on a global scale by atmospheric nuclear weapon tests carried during the 1950s-1960s and the Chernobyl nuclear accident in 1986; ii) at a regional level, by the low level radioactive discharges from the Marcoule nuclear reprocessing plant between 1958 and 1997; iii) and locally by the Palomares accident in 1966. Knowledge on their respective contributions to the presence of 129I, 236U, 237Np and Pu isotopes and on the radionuclide distributions in the Mediterranean Sea was limited or completely unknown. Our data on 129I and 236U showed that their distributions are governed by the thermohaline circulation, and highlighted the importance of constraining each radionuclide source. In particular, we estimated that the contamination derived from the Marcoule nuclear reprocessing plant was likely comparable to that from global fallout for 236U (10-20 kg) and about 2 orders of magnitude larger for 129I (70-90 kg). We also reported for the first time a comprehensive transect of 237Np. The distributions of both 237Np and 137Cs are driven by the circulation of the water masses, as expected for conservative radionuclides. The principal sources of 237Np were found to be global fallout and Marcoule, the later probably contributing to about 30% of the 237Np (~7 kg) present in the Mediterranean Sea in 2013. The distribution of 137Cs showed the influence of inputs and recent changes in circulation. The main source of Pu was confirmed to be global fallout, as shown by the 240Pu/239Pu atom ratios of about 0.18 throughout the Mediterranean Sea. The distribution of 239,240Pu was affected by, in addition to circulation, particle scavenging and remineralization. A notable result of this study was the lower levels of 239,240Pu in the water column of the Eastern Basin than in the Western Basin that were possible due to enchanced boundary scavenging on shelf sediments or the limited scavenging by particles in open waters and enhanced westward transport by water dynamics.
Sampaio, Jarbas Cordeiro [UNESP]. "Efeitos de maré no movimento orbital de satélites artificiais." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/91818.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Os satélites artificiais são utilizados em várias atividades científicas como em geodinâmica, telecomunicações, estudo do clima, experiências com microgravidade, dentre outras. Para alcançar a precisão necessária para certas missões, as órbitas devem ser determinadas com bastante precisão levando em consideração várias forças que atuam nos satélites. O efeito de maré é uma das perturbações que afetam a órbita de um satélite artificial, pois tanto o Sol como a Lua deformam o planeta, alterando assim a distribuição de massa e o potencial utilizado para estudar a variação nos elementos orbitais do satélite. Neste trabalho estuda-se a influência da maré terrestre e oceânica da Terra sobre satélites artificiais que a orbitam. Foi desenvolvida a função perturbadora para a maré terrestre, com base tanto no modelo de Kozai como no de Kaula e para a maré oceânica é adotado o modelo de Harwood e Swinerd. Os desenvolvimentos das funções perturbadoras são feitos em termos do polinômio de Legendre, aproveitando a parte secular e de longo período para estudar a variação dos elementos orbitais do satélite. Resultados das soluções seculares indicam a maior contribuição da Lua, em comparação à contribuição do Sol. Também, as perturbações devido a maré terrestre são mais proeminentes do que a maré oceânica para ambos os satélites de baixa e de alta altitude. Considerando as soluções de longo período para o satélite de baixa altitude, os resultados mostram que, para o argumento do perigeu e para a excentricidade , o período de oscilação é maior para a maré oceânica comparado a maré terrestre. Considerando os diferentes modelos para as marés, também para o satélite de baixa altitude, é mostrado que a maior variação de amplitude é para o argumento do perigeu. Perturbações devido a ressonâncias são também analisadas para os elementos orbitais métricos.
Artificial Earth’s satellites are used in several scientific activities such as geodynamics, telecommunications, climate forecast, microgravity experiments, among others. In order to attain the precision needed for some missions the orbits must be determined with high accuracy taking into account several forces acting on the satellites. The tide effect is one of the disturbances that affect the orbit of an artificial satellite. In fact, both the Sun and the Moon deforms the planet and thus modifies its mass distribution and the used potential to study the variation in the orbital elements of the satellite. In this work it is studied the influence of the terrestrial and oceanic tides on artificial Earth’s satellites orbits. The disturbing functions for the terrestrial tide was developed based on the Kozai and Kaula models and for the oceanic tide was used Harwood and Swinerd model. The developments of the disturbing functions are performed in terms of the Legendre polynomials, using the secular and long period terms to study the variation of the orbital elements of the satellite. Results for the secular solution show the bigger contribution of the Moon, compared to the contribution of the Sun. Also, the perturbations due to the terrestrial tide are more noticeable than of the oceanic tide for both low and higher altitude satellites. Considering the long period solution for low altitude satellite, the results show that, for the argument of perigee and the eccentricity, the period of oscillation is bigger for the oceanic tide compared to the terrestrial tide. Considering different models for the tides, also for low altitude satellite, it is shown that the greatest amplitude’s variation is for argument of perigee. Perturbations due to resonance are also analyzed for the metric orbital elements.
Mazzola, Andrea. "Evoluzione della pressione antropica sui corsi d'acqua nel sud-est asiatico mediante dati satellitari." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
Find full textAriza, Zambrano William Camilo 1989. "Controle ativo de vibrações usando redes neurais artificiais : Active vibration control using artificial neural networks." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/264927.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecânica
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Resumo: Este trabalho tem como objetivo principal o estudo de um método de controle baseado no uso de redes neurais artificiais aplicado ao problema de controle de vibrações em estruturas flexíveis. Este trabalho centra-se no estudo do esquema de controle inverso-direto, que consiste em identificar a dinâmica inversa da planta através de uma rede neural artificial para ser usada como controlador. Três exemplos de aplicação foram resolvidos utilizando-se controladores projetados com o método inverso-direto. A primeira aplicação é o controle de vibrações em uma estrutura mecânica de parâmetros concentrados. O segundo exemplo de aplicação é o controle de vibrações de uma placa engastada em uma de suas extremidades. Neste caso, a placa engastada foi modelada utilizando-se o método de elementos finitos. No seguinte exemplo, o modelo da placa usado no exemplo anterior foi reduzido, deixando apenas os primeiros modos de vibração. No último exemplo tratou-se o problema de controle não colocado das vibrações em uma placa engastada. Os resultados foram analisados a partir da resposta temporal e da resposta em frequência do sistema em malha fechada. Para comparar os resultados obtidos utilizando-se o método de controle baseado em redes neurais artificiais, os exemplos citados anteriormente foram também resolvidos utilizando-se o método de controle ??. Os resultados obtidos demonstram que o método de controle baseado em modelo inverso usando redes neurais foi eficaz na resolução deste tipo de problema
Abstract: The goal of this work is to study a control method based on artificial neural networks applied to the vibration control of flexible structures problem. This work focuses in the direct-inverse control scheme which consists of identifing the inverse dynamics of the plant through an artificial neural network to be used as the controller. Three application examples using the direct-inverse method were solved. The first application is the vibration control in a mechanical structure of concentrated parameters. The second application example is the vibration control of a cantilever plate. The cantilever plate was modeled using the finite elements method. In the third example, a reduction of the cantilever plate model was made. In the last example a non-collocated control problem of vibration in a cantilever plate was treated. The results of the scheme were evaluated according to the temporal response and the frequency response of the closed-loop system. In order to compare the results obtained using the control method based on artificial neural networks, the previous examples were also solved using the ?? control method. The obtained results show that the control method based on inverse model using neural networks was effective in solving this kind of problem
Mestrado
Mecanica dos Sólidos e Projeto Mecanico
Mestre em Engenharia Mecânica
Reali, Egidio Henrique. "Utilização de inteligência artificial - (Redes neurais artificiais) no gerenciamento da produção de frangos de corte." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2004. http://hdl.handle.net/10183/6339.
Full textLanzarone, Lorenzo Biagio. "Manutenzione predittiva di macchinari industriali tramite tecniche di intelligenza artificiale: una valutazione sperimentale." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/22853/.
Full textSampaio, Jarbas Cordeiro. "Efeitos de maré no movimento orbital de satélites artificiais /." Guaratinguetá : [s.n.], 2009. http://hdl.handle.net/11449/91818.
Full textBanca: Maria Cecília França de Paula Zanardi
Banca: Helio Koiti Kuga
Resumo: Os satélites artificiais são utilizados em várias atividades científicas como em geodinâmica, telecomunicações, estudo do clima, experiências com microgravidade, dentre outras. Para alcançar a precisão necessária para certas missões, as órbitas devem ser determinadas com bastante precisão levando em consideração várias forças que atuam nos satélites. O efeito de maré é uma das perturbações que afetam a órbita de um satélite artificial, pois tanto o Sol como a Lua deformam o planeta, alterando assim a distribuição de massa e o potencial utilizado para estudar a variação nos elementos orbitais do satélite. Neste trabalho estuda-se a influência da maré terrestre e oceânica da Terra sobre satélites artificiais que a orbitam. Foi desenvolvida a função perturbadora para a maré terrestre, com base tanto no modelo de Kozai como no de Kaula e para a maré oceânica é adotado o modelo de Harwood e Swinerd. Os desenvolvimentos das funções perturbadoras são feitos em termos do polinômio de Legendre, aproveitando a parte secular e de longo período para estudar a variação dos elementos orbitais do satélite. Resultados das soluções seculares indicam a maior contribuição da Lua, em comparação à contribuição do Sol. Também, as perturbações devido a maré terrestre são mais proeminentes do que a maré oceânica para ambos os satélites de baixa e de alta altitude. Considerando as soluções de longo período para o satélite de baixa altitude, os resultados mostram que, para o argumento do perigeu e para a excentricidade , o período de oscilação é maior para a maré oceânica comparado a maré terrestre. Considerando os diferentes modelos para as marés, também para o satélite de baixa altitude, é mostrado que a maior variação de amplitude é para o argumento do perigeu. Perturbações devido a ressonâncias são também analisadas para os elementos orbitais métricos.
Abstract: Artificial Earth's satellites are used in several scientific activities such as geodynamics, telecommunications, climate forecast, microgravity experiments, among others. In order to attain the precision needed for some missions the orbits must be determined with high accuracy taking into account several forces acting on the satellites. The tide effect is one of the disturbances that affect the orbit of an artificial satellite. In fact, both the Sun and the Moon deforms the planet and thus modifies its mass distribution and the used potential to study the variation in the orbital elements of the satellite. In this work it is studied the influence of the terrestrial and oceanic tides on artificial Earth's satellites orbits. The disturbing functions for the terrestrial tide was developed based on the Kozai and Kaula models and for the oceanic tide was used Harwood and Swinerd model. The developments of the disturbing functions are performed in terms of the Legendre polynomials, using the secular and long period terms to study the variation of the orbital elements of the satellite. Results for the secular solution show the bigger contribution of the Moon, compared to the contribution of the Sun. Also, the perturbations due to the terrestrial tide are more noticeable than of the oceanic tide for both low and higher altitude satellites. Considering the long period solution for low altitude satellite, the results show that, for the argument of perigee and the eccentricity, the period of oscillation is bigger for the oceanic tide compared to the terrestrial tide. Considering different models for the tides, also for low altitude satellite, it is shown that the greatest amplitude's variation is for argument of perigee. Perturbations due to resonance are also analyzed for the metric orbital elements.
Mestre
Saccardo, Paolo. "Development of artificial viruses for nanomedicine and gene therapy." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/287907.
Full textThe convergence of different field as biotechnology, molecular biology and genetic engineering in the development of a nano-scale therapeutical vector became matter of interest because of their nanomedical applications. The major challenge of nanovectors is obtain a good delivery of nucleic acid, therapeutic proteins or drugs, with high cell specificity and low side effects. In this way, viral vectors allow an extremely efficient delivery but are also responsible of severe side effects. Because of this main limitation, the development of artificial virus derived from either dendrimers, liposomes, polymers, modular proteins or virus like particles (VLPs) is considered an interesting and promising research field. In this thesis we expose our studies in the optimization of protein self-assembling nanoparticles. From one side we produced and characterized VLPs derived form the major capsid protein VP1 of the human JC virus both in E. coli and insect cells protein factories. On the other side we studied the optimization of the self-assembling and the purification process of multi-domain self-assembling proteins derived by paradigmatic protein R9-GFP-H6, which is described to form nanoparticles. Different genetic backgrounds for protein quality control system in E. coli have shown to alter the protein production yield and conformational quality of artificial virus assembly. We discuss in this thesis the effects of the prokaryotic DnaK chaperone on VP1 production yield and VLPs conformation quality. For this purpose we used three genetic backgrounds including, wild type expression, over-expression and absence of expression of DnaK molecular chaperone. Surprisingly, in the absence of the molecular chaperone the production yield of VP1 is enhanced but has negative effects on VLPs assembly. Moreover we tested different buffer formulations in order to establish the optimal salt concentration and pH for VLP organization, stabilization and conformation. The same concept where applied for insect cell system, exploring the effects in yield and conformational quality of VP1 hJCV VLPs upon re-hosting DnaK/DnaJ chaperones. Results showed a lowering in production yield upon chaperone co-expression but an increase in VLPs conformational quality. At the same time architectural properties of the paradigm protein R9-GFP-H6 and its interactions with DNA were studied in order to obtain a suitable protein-based artificial virus for gene delivery. It has been observed that in presence of DNA and at slightly acidic pH, R9-GFP-H6 proteins organize in two distinct populations. Microscopy observations showed a supramolecular organization of DNA/nanoparticle complexes, revealing the 9 Arginine and 6 Histidines blocks as promising pleyotropic domains. Moreover, in optimized conditions, R9-GFP-H6 protein has also showed an effective DNA protection against proteases. Finally, we purposed potential structural models of R9-GFP-H6/DNA complexes, based on bioinformatics analysis and experimental data. Subsequently we explored the nucleic acid contaminants in non-viral protein based nanovector production process of R9-GFP-H6 derivative proteins. Enzymatic downstream treatment with nucleases has revealed a good strategy to solve the limitations derived from nucleic acid contamination. All together, these works allows having a general overview of non-viral nanoparticles approach in gene delivery and permitting to understand better the difficulties in the production process. With this thesis, then, we claim to discuss and develop newly production and purification methods in order to develop efficient artificial virus for nanomedicine and gene therapy.
El, Haj Hidalgo Cristina. "Estudios de eficacia antimicrobiana frente a la infección de cuerpo extraño por Staphylococcus aureus: aplicación de un modelo in vivo y un modelo dinámico in vitro." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/565664.
Full textDespite optimal therapeutic management for acute prosthetic joint infections (PJI) caused by Staphylocococcus aureus, some clinical and microbiological failures occur, especially when implant retention is attempted. Moreover, occasions arise when drugs often cannot be administered owing to intolerance or allergy, and no adequately evaluated alternatives exist. In response to these difficulties, alternative therapies and other therapeutic approaches to bacterial biofilm are been investigated. Daptomycin combinations had a high efficacy against foreign-body infection by methicillin- resistant S. aureus (MRSA). On the other hand, the information about the potential anti-biofilm effect of macrolides against S. aureus is scarce and controversial. Additionally, the alternative therapies for S.aureus infections (ie cotrimoxazole and fusidic acid) have not been accurately evaluated. The aims of this project was standardize an dynamic in vitro model (CDC biofilm reactor) and an in vivo foreign-body infection (FBI) by methicillin-susceptible S. aureus (SASM) and MRSA strains, in order to evaluate (i) The efficacy of daptomycin and its combinations against SASM; (ii) the potential anti-biofilm effect of clarithromycin; and (iii) the activity of cotrimoxazole, fusidic acid and rifampicin combinations with cotrimoxazole and linezolid as possible therapeutic alternatives to the standard treatment for S. aureus. The main results were: - The In vivo model with a period of infection of 3 and 7 days, as an acute FBI model, and the dynamic in vitro model of CDC biofilm reactor were suitable to study the efficacy of different therapies. -Daptomycin-Cloxacillin therapy was as effective as cloxacillin-rifampicin (standard treatment) and can be considered as alternative anti-MSSA therapy for FBI. -Daptomycin-Rifampicin was the most effective combination, providing higher efficacy than levofloxacin-rifampicin. These results suggest that daptomycin-rifampicin may be useful as a first-line therapy against MSSA PJI. -Clarithromycin did not show anti-biofilm activity against MSSA and MRSA infections. -Cotrimoxazole was ineffective against S.aureus in animal model. The results observed suggest that the lack of activity could be due in part to its inactivation by thymidine. -Fusidic acid had promising microbiological results. However, it was not possible to perform the in vivo studies due to the animal intolerance to antibiotic. - In CDC biofilm reactor, levofloxacin-rifampicin was the most effective treatment against MSSA. Rifampicin combinations with cotrimoxazole and linezolid had similar activity. Against MRSA, linezolid-rifampicin combination was the most effective treatment. In both strains, the cotrimoxazole-rifampicin combination did not protect against rifampicin resistant strains.
Pisana, Giuseppe. "Luigi G. Jacchia, un triestino a Bologna: dai cieli di Loiano all'epopea spaziale americana." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/17880/.
Full textFarguell, Matesanz Enric. "A new approach to Decimation in High Order Boltzmann Machines." Doctoral thesis, Universitat Ramon Llull, 2011. http://hdl.handle.net/10803/9155.
Full textMalgrat aquesta relativa manca d'èxit, la comunitat científica de l'àmbit de les xarxes neuronals ha mantingut un cert interès amb el model. Una de les extensions més rellevants a la MB és la Màquina de Boltzmann d'Alt Ordre (HOBM), on els pesos poden connectar més de dues neurones simultàniament. Encara que les capacitats d'aprenentatge d'aquest model han estat analitzades per d'altres autors, no s'ha pogut establir una equivalència formal entre els pesos d'una MB i els pesos d'alt ordre de la HOBM.
En aquest treball s'analitza l'equivalència entre una MB i una HOBM a través de l'extensió del mètode conegut com a decimació. Decimació és una eina emprada a física estadística que es pot també aplicar a cert tipus de MB, obtenint expressions analítiques per a calcular les correlacions necessàries per a dur a terme el procés d'aprenentatge. Per tant, la decimació evita l'ús del costós algorisme del SA. Malgrat això, en la seva forma original, la decimació podia tan sols ser aplicada a cert tipus de topologies molt poc densament connectades. La extensió que es defineix en aquest treball permet calcular aquests valors independentment de la topologia de la xarxa neuronal; aquest model es basa en afegir prou pesos d'alt ordre a una MB estàndard com per a assegurar que les equacions de la decimació es poden solucionar.
Després, s'estableix una equivalència directa entre els pesos d'un model d'alt ordre, la distribució de probabilitat que pot aprendre i les matrius de Hadamard: les propietats d'aquestes matrius es poden emprar per a calcular fàcilment els pesos del sistema. Finalment, es defineix una MB estàndard amb una topologia específica que permet entendre millor la equivalència exacta entre unitats ocultes de la MB i els pesos d'alt ordre de la HOBM.
La Máquina de Boltzmann (MB) es una red neuronal estocástica con la habilidad de aprender y extrapolar distribuciones de probabilidad. Sin embargo, nunca ha llegado a ser tan popular como otros modelos de redes neuronals como, por ejemplo, el perceptrón. Esto es debido a la complejidad tanto del proceso de simulación como de aprendizaje: las cantidades que se necesitan a lo largo del proceso de aprendizaje se estiman mediante el uso de técnicas Monte Carlo (MC), a través del algoritmo del Temple Simulado (SA). En definitiva, la MB es generalmente considerada o bien una extensión de la red de Hopfield o bien como una implementación paralela del algoritmo del SA.
Pese a esta relativa falta de éxito, la comunidad científica del ámbito de las redes neuronales ha mantenido un cierto interés en el modelo. Una importante extensión es la Màquina de Boltzmann de Alto Orden (HOBM), en la que los pesos pueden conectar más de dos neuronas a la vez. Pese a que este modelo ha sido analizado en profundidad por otros autores, todavía no se ha descrito una equivalencia formal entre los pesos de una MB i las conexiones de alto orden de una HOBM.
En este trabajo se ha analizado la equivalencia entre una MB i una HOBM, a través de la extensión del método conocido como decimación. La decimación es una herramienta propia de la física estadística que también puede ser aplicada a ciertos modelos de MB, obteniendo expresiones analíticas para el cálculo de las cantidades necesarias en el algoritmo de aprendizaje. Por lo tanto, la decimación evita el alto coste computacional asociado al al uso del costoso algoritmo del SA. Pese a esto, en su forma original la decimación tan solo podía ser aplicada a ciertas topologías de MB, distinguidas por ser poco densamente conectadas. La extensión definida en este trabajo permite calcular estos valores independientemente de la topología de la red neuronal: este modelo se basa en añadir suficientes pesos de alto orden a una MB estándar como para asegurar que las ecuaciones de decimación pueden solucionarse.
Más adelante, se establece una equivalencia directa entre los pesos de un modelo de alto orden, la distribución de probabilidad que puede aprender y las matrices tipo Hadamard. Las propiedades de este tipo de matrices se pueden usar para calcular fácilmente los pesos del sistema. Finalmente, se define una BM estándar con una topología específica que permite entender mejor la equivalencia exacta entre neuronas ocultas en la MB y los pesos de alto orden de la HOBM.
The Boltzmann Machine (BM) is a stochastic neural network with the ability of both learning and extrapolating probability distributions. However, it has never been as widely used as other neural networks such as the perceptron, due to the complexity of both the learning and recalling algorithms, and to the high computational cost required in the learning process: the quantities that are needed at the learning stage are usually estimated by Monte Carlo (MC) through the Simulated Annealing (SA) algorithm. This has led to a situation where the BM is rather considered as an evolution of the Hopfield Neural Network or as a parallel implementation of the Simulated Annealing algorithm.
Despite this relative lack of success, the neural network community has continued to progress in the analysis of the dynamics of the model. One remarkable extension is the High Order Boltzmann Machine (HOBM), where weights can connect more than two neurons at a time. Although the learning capabilities of this model have already been discussed by other authors, a formal equivalence between the weights in a standard BM and the high order weights in a HOBM has not yet been established.
We analyze this latter equivalence between a second order BM and a HOBM by proposing an extension of the method known as decimation. Decimation is a common tool in statistical physics that may be applied to some kind of BMs, that can be used to obtain analytical expressions for the n-unit correlation elements required in the learning process. In this way, decimation avoids using the time consuming Simulated Annealing algorithm. However, as it was first conceived, it could only deal with sparsely connected neural networks. The extension that we define in this thesis allows computing the same quantities irrespective of the topology of the network. This method is based on adding enough high order weights to a standard BM to guarantee that the system can be solved.
Next, we establish a direct equivalence between the weights of a HOBM model, the probability distribution to be learnt and Hadamard matrices. The properties of these matrices can be used to easily calculate the value of the weights of the system. Finally, we define a standard BM with a very specific topology that helps us better understand the exact equivalence between hidden units in a BM and high order weights in a HOBM.
[UNESP], Santos Nadjara dos. "Pertubações orbitais devidas a maré terrestre." Universidade Estadual Paulista (UNESP), 2002. http://hdl.handle.net/11449/89857.
Full textAplicações recentes de satélites artificiais, principalmente aquelas com finalidades geodinâmicas e altimétricas, requerem órbitas determinadas com bastante precisão. Em particular as marés terrestres alteram o geopotencial, causando perturbações adicionais no movimento do satélite. Tais perturbações, apesar de pequenas, têm sido detectadas. O presente trabalho trata de perturbações de órbitas de satélites artificiais devidas às marés terrestres. Ênfase é dada aos termos seculares e de longo período. O potencial foi desenvolvido em termos dos elementos orbitais e substituídos nas equações planetárias de Lagrange. Soluções analíticas estão apresentadas para casos particulares considerando os números de Love constantes. Um programa foi elaborado, e colocado a disposição do usuário, permitindo calcular, para um dado satélite, a amplitude e o período dos termos perturbadores mais significativos.
Recent applications of artificial satellites, mainly those of geodynamics and altimetric purposes, requires high precise orbit determination. Particularly, Earth tides change the geopotencial causing additional perturbation in the satellite orbital motion. Inspite of being very small such perturbations, has been detected. The present work concerns about orbit perturbations of artificial satellites due do terrestrial tides. Treatment of secular and long period terms is emphasized. The potencial was developed in terms of the orbital elements and substituted in the Lagrange equations. Analytical solutions are presented for particular cases considering the Love’s number as constant. A computer enabling to compute, for a given satellite, the amplitude and period of the more significant disturbing terms, was constructed and it is, at the disposal for users.
Garcia, Roberta Veloso [UNESP]. "Satelites estabilizados por rotação e torque magnético residual." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/91828.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Universidade Estadual Paulista (UNESP)
Uma abordagem analítica para o movimento rotacional de satélites artificiais estabilizados por rotação é apresentada, considerando os satélites em órbita elíptica e a influência do torque magnético residual. O torque magnético residual resulta da interação entre o campo magnético residual do satélite e o campo geomagnético, sendo este representado pelo modelo de quadripolo. As equações do movimento são descritas em termos do módulo da velocidade de rotação do satélite, da declinação e da ascensão reta do eixo de rotação do satélite. As componentes médias do torque residual em um sistema fixo no satélite são determinadas para um período orbital. Uma solução analítica para as equações do movimento é determinada, sendo válida para um período orbital. Por esta solução observa-se que o torque residual não afeta o módulo da velocidade de rotação, contribuindo apenas para as variações temporais da ascensão reta e declinação do eixo de rotação, associadas com a precessão e deriva do eixo de rotação do satélite. Aplicações são realizadas para os Satélites de Coleta de Dados Brasileiros SCD1 e SCD2, mostrando uma concordância entre os resultados obtidos pela teoria e os dados fornecidos pelo Centro de Controle de Satélites do INPE. O comportamento do erro gerado na direção do eixo de rotação do satélite é também apresentado, sendo que os desvios obtidos se mostram de acordo com as precisões requeridas para as missões destes satélites.
An analytical approach is show for attitude motion of the spin stabilized artificial satellite in an elliptic orbit. Residual magnetic torque is considered and the geomagnetic torque is defined by the quadripole model. The equations of motion are described by the magnitude of the spin velocity, right ascension and declination of the spin axis. The components of the averaged residual torque are computed for one orbital period in a satellite reference system. An analytical solution is presented and it is valid for one orbit period. By this solution it is possible to observe that the residual torque causes the precession and the drift of the spin axis, but it does not affect the magnitude of spin velocity. Some applications are done for Brazilian Satellite SCD1 and SCD2, and they show the agreement of the theory results and the data provide by INPE Satellite Control Center. The behavior of the error in the spin axis direction is also presented and this error agrees with the required precision of these satellite missions.
Rodrigues, Maíra Ribeiro. "Um sistema de valores de troca para suporte às interações em sociedades artificiais." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2003. http://hdl.handle.net/10183/2687.
Full textEskandani, Zahra. "Canaux symétriques à base de cyclodextrines amphiphiles : polymérisation divergente d'oxirane." Thesis, Evry-Val d'Essonne, 2011. http://www.theses.fr/2011EVRY0002/document.
Full textIn this work, we present the design of artificial permanent cyclodextrin-based channels, obtained by divergent polymerization. Selective modifications of cyclodextrins have been developed to generate original initiators of ethylene oxide ring-opening polymerization. Considering the experimental conditions used, the demonstration of controlled polymerization was performed, leading to molecules with 14 PEO arms having various molar masses. Among various applications, we focused on the possibility to use this new class of star-polymer architectures as permanent ionic channels exhibiting long residence time (hour scale), paving the way to translocation of molecules and macromolecules for example
Pegorini, Vinicius. "Classificação de padrões de mastigação de ruminantes utilizando aprendizagem de máquina." Universidade Tecnológica Federal do Paraná, 2015. http://repositorio.utfpr.edu.br/jspui/handle/1/1508.
Full textIn this work, a system to automate the classification of chewing patterns of ruminants is developed. Pattern classification of ingestive behavior in grazing animals has extreme importance in studies related to animal nutrition, growing and health. The proposal is based on data collected by optical fiber Bragg grating sensors (FBG). The collected data are processed by machine learning techniques. The FBG sensors measure the biomechanical strain during jaw movements. In vitro tests were performed based on a cadaveric mandible of a goat and in vivo tests were performed by monitoring the food intake process of a steer. For the pattern classification a classic model of decision tree and artificial neural network were used. Experimental results show that the proposed approaches for pattern classification have been capable to differentiate the materials and events involved in the chewing process. Experimental results show that it is possible to classify different forage and events involved in the ingestive behaviour of ruminants, that contributes to improving the current methodology for monitoring the animal consumption efficiency.