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1

Arung, Enos Tangke, Kuniyoshi Shimizu, and Ryuichiro Kondo. "Artocarpus Plants as a Potential Source of Skin Whitening Agents." Natural Product Communications 6, no. 9 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600943.

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Artocarpus plants have been a focus of constant attention due to the potential for skin whitening agents. In the in vitro experiment, compounds from the Artocarpus plants, such as artocarpanone, norartocarpetin, artocarpesin, artogomezianol, andalasin, artocarbene, and chlorophorin showed tyrosinase inhibitory activity. Structure-activity investigations revealed that the 4-substituted resorcinol moiety in these compounds was responsible for their potent inhibitory activities on tyrosinase. In the in vitro assay, using B16 melanoma cells, the prenylated polyphenols isolated from Artocarpus plan
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2

Suhartati, Tati, Khalimatus Sa’diah, Yandri Yandri, and Sutopo Hadi. "Anticancer Activity Study of Modified Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.)." Emerging Science Journal 7, no. 3 (2023): 733–43. http://dx.doi.org/10.28991/esj-2023-07-03-05.

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This research is a continuation of the successful isolation of artocarpin from the root of Artocarpus kemando Miq reported in our previous study. In the previous study, the artocarpin was characterized with UV-Vis and FTIR techniques. In this follow-up investigation, the artocarpin was subjected to a transesterification reaction using acetic anhydride and pyridine as catalysts, and the product of the reaction was specified as compound 1. The compound 1 was further characterized with different techniques to gain more complete data and then tested for anticancer activity test against P-388 murin
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3

Sell, Ana Maria, and Celso Paulino da Costa. "Effects of plant lectins on in vitro fibroblast proliferation." Brazilian Archives of Biology and Technology 46, no. 3 (2003): 349–54. http://dx.doi.org/10.1590/s1516-89132003000300006.

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Lectins are carbohydrate-binding proteins that have been isolated from various sources and presented a wide spectrum of biological activities. The effects of four lectins, namely, Phaseolus vulgaris phytohemagglutinin, PHA, wheat germ agglutinin, WGA, Artocarpus integrifolia seed lectins, jacalin and artocarpin, on in vitro fibroblasts proliferation were investigated. The lectins did not influence the initial cell adhesion to the plate. PHA and WGA at 10-20 µg/mL concentrations significantly decreased fibroblasts proliferation. At these concentrations, they caused morphological alterations on
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4

Septama, Abdi Wira, and Eldiza Puji Rahmi, M.Sc. "SYNERGISTIC EFFECT OF COMBINATION BETWEEN CYANOMACLURIN AND ARTOCARPIN FROM ARTOCARPUS HETEROPHYLLUS HEARTWOODS AGAINSTS STREPTOCOCCUS PYOGENES AND STAPHYLOCOCCUS EPIDERMIDIS." Journal of Research in Pharmacy and Pharmaceutical Sciences 1, no. 1 (2022): 21–25. http://dx.doi.org/10.33533/jrpps.v1i1.4250.

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Streptococcus pyogenes and Staphylococcus epidermidis are major problem of human health and may generate antibacterial resistance problem. Flavonoid has been used for the treatment of several ailments including bacterial infection. Artocarpus heterophyllus is a potential source of flavonoid compounds such as artocarpin and cyanomaclurin. The study was conducted to observe synergistic effects between flavonoid compounds against S. pyogenes and S. epidermidis. The antibacterial activity of combination of artocarpin and cyanomaclurin isolated from A. heterophyllus heartwoods were evaluated agains
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5

Suhartati, Tati, Eka Epriyanti, Inggit Borisha, et al. "In Vivo Antimalarial Test of Artocarpin and in vitro Antimalarial Test of Artonin M Isolated from Artocarpus." Revista de Chimie 71, no. 5 (2020): 400–408. http://dx.doi.org/10.37358/rc.20.5.8150.

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The derivative of flavonoid compounds, artocarpin (1) and artonin M (2), were isolated from the root wood of Artocarpus altilis and from the root bark of A. kemando, respectively. Both plants originated from Lampung, Indonesia. The structure of the two compounds has been carefully determined by physical method and spectroscopy techniques of UV, IR, and NMR. The in vivo antimalarial test of artocarpin showed very good Plasmodium activity in female mice, with ED50 value of 34.88 mg/kg body weight (kgBW), whereas the in vitro antimalarial test of artonin M showed very strong activity with IC50 of
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6

Chowdhury, S., H. Ahmed, and B. P. Chatterjee. "Chemical modification studies of Artocarpus lakoocha lectin artocarpin." Biochimie 73, no. 5 (1991): 563–71. http://dx.doi.org/10.1016/0300-9084(91)90024-u.

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7

Hu, Stephen Chu-Sung, Chi-Ling Lin, Hui-Min Cheng, Gwo-Shing Chen, Chiang-Wen Lee, and Feng-Lin Yen. "Artocarpin Induces Apoptosis in Human Cutaneous Squamous Cell Carcinoma HSC-1 Cells and Its Cytotoxic Activity Is Dependent on Protein-Nutrient Concentration." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/236159.

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Artocarpin, a natural prenylated flavonoid, has been shown to have various biological properties. However, its effects on human cutaneous squamous cell carcinoma (SCC) have not been previously investigated. We set out to determine whether artocarpin has cytotoxic effects on SCC cells and whether its pharmacological activity is dependent on protein-nutrient concentration. Our results showed that treatment of HSC-1 cells (a human cutaneous SCC cell line) with artocarpin decreased cell viability and induced cell apoptosis by increasing caspase 3/7 activity. These effects were more pronounced at l
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8

Suresh, S., P. G. Rani, J. V. Pratap, R. Sankaranarayanan, A. Surolia, and M. Vijayan. "Homology between jacalin and artocarpin from jackfruit (Artocarpus integrifolia) seeds. Partial sequence and preliminary crystallographic studies of artocarpin." Acta Crystallographica Section D Biological Crystallography 53, no. 4 (1997): 469–71. http://dx.doi.org/10.1107/s0907444997000851.

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9

Chowdhury, Sunanda, and Bishnu P. Charterjee. "Artocarpin-galactomannan interaction: Characterization of combining site of artocarpin." Phytochemistry 32, no. 2 (1993): 243–49. http://dx.doi.org/10.1016/s0031-9422(00)94975-6.

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10

Nonpanya, Nongyao, Kittipong Sanookpan, Nicharat Sriratanasak, et al. "Artocarpin Targets Focal Adhesion Kinase-Dependent Epithelial to Mesenchymal Transition and Suppresses Migratory-Associated Integrins in Lung Cancer Cells." Pharmaceutics 13, no. 4 (2021): 554. http://dx.doi.org/10.3390/pharmaceutics13040554.

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Focal adhesion kinase (FAK) controls several cancer aggressive potentials of cell movement and dissemination. As epithelial–mesenchymal transition (EMT) and the migratory-associated integrins, known influencers of metastasis, have been found to be linked with FAK activity, this study unraveled the potential pharmacological effect of artocarpin in targeting FAK resulting in the suppression of EMT and migratory behaviors of lung cancer cells. Treatment with artocarpin was applied at concentrations of 0–10 μM, and the results showed non-cytotoxicity in lung cancer cell lines (A549 and H460), norm
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11

Lathiff, Siti Mariam Abdul, Noraini Jemaon, Siti Awanis Abdullah, and Shajarahtunnur Jamil. "Flavonoids from Artocarpus anisophyllus and their Bioactivities." Natural Product Communications 10, no. 3 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000305.

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Two new prenylated flavonoids, 4′,5-dihydroxy-6,7-(2,2-dimethylpyrano)-2′-methoxy-8-γ,γ-dimethylallylflavone 1 and 3′-hydroxycycloartocarpin 2 along with six known flavonoids, 5,7-dihydroxy-4′-methoxy-8-prenylflavanone 3, isobavachalcone 4, pyranocycloartobiloxanthone A 5, artocarpin 6, chaplashin 7 and cycloartocarpin 8 were isolated for the first time from the leaves and the heartwoods of Artocarpus anisophyllus Miq. The structures of isolated flavonoids were elucidated spectroscopically using 1D and 2D NMR, FTIR, MS, UV and also by comparison with literature data. These flavonoids were scre
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12

Chantrapromma, Suchada, Nawong Boonnak, Hoong-Kun Fun, and Chatchanok Karalai. "Artocarpin dichloromethane hemisolvate." Acta Crystallographica Section E Structure Reports Online 63, no. 4 (2007): o1864—o1866. http://dx.doi.org/10.1107/s1600536807011646.

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13

Preud'homme, J. L., P. Aucouturier, and N. Gualde. "Jacalin and artocarpin." Journal of Immunological Methods 146, no. 2 (1992): 259–60. http://dx.doi.org/10.1016/0022-1759(92)90236-m.

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14

Septama, AbdiWira, Nordin Simbak, Nik NurulNajihah Nik Mat Daud, and EldizaPuji Rahmi. "The phytochemical and pharmacological properties of artocarpin from Artocarpus heterophyllus." Asian Pacific Journal of Tropical Medicine 13, no. 1 (2020): 1. http://dx.doi.org/10.4103/1995-7645.273567.

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15

Chatterjee, Bishnu P., Hafiz Ahmed, and Sunanda Chowdhury. "Further characterization of Artocarpus lakoocha lectin (artocarpin) purified using rivanol." Carbohydrate Research 180, no. 1 (1988): 97–110. http://dx.doi.org/10.1016/0008-6215(88)80067-3.

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16

Tzeng, Cheng-Wei, Feng-Lin Yen, Liang-Tzung Lin, et al. "Antihepatoma Activity ofArtocarpus communisIs Higher in Fractions with High Artocarpin Content." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/978525.

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Extracts from natural plants have been used in traditional medicine for many centuries worldwide.Artocarpus communisis one such plant that has been used to treat liver cirrhosis, hypertension, and diabetes. To our knowledge, this study is the first to investigate the antihepatoma activity ofA. communistoward HepG2 and PLC/PRF/5 cells and the first to explore the relationship between antihepatoma activity and the active compound artocarpin content in different fractions ofA. communis.A. communismethanol extract and fractions induced dose-dependent reduction of tumor cell viability. DNA ladderin
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17

Chiang Chan, Eric Wei, Siu Kuin Wong, Joseph Tangah, and Hung Tuck Chan. "Chemistry and Pharmacology of Artocarpin: An Isoprenyl Flavone from Artocarpus Species." Systematic Reviews in Pharmacy 9, no. 1 (2018): 58–63. http://dx.doi.org/10.5530/srp.2018.1.12.

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18

Luangpraditkun, Kunlathida, Marion Tissot, Anupong Joompang, et al. "Prevention by the Natural Artocarpin of Morphological and Biochemical Alterations on UVB-Induced HaCaT Cells." Oxidative Medicine and Cellular Longevity 2021 (July 6, 2021): 1–13. http://dx.doi.org/10.1155/2021/5067957.

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Natural substances have gained considerable attention for skin protection against UV light reactions. Artocarpus altilis plant’s heartwood extract is comprised of artocarpin as a major substance, already known for its interesting biological attributes as an antimicrobial, an anti-inflammatory, an antioxidant, and a melanogenesis inhibitor. The present work clarified the mechanism of natural artocarpin (NAR) with a purity of approximately 99% against the effects of UVB-induced HaCaT keratinocyte apoptosis. The indicated results showed that NAR suppresses free radical production (ROS and nitrite
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19

Sun, Guochuan, Zongping Zheng, Mee-Hyun Lee, et al. "Chemoprevention of Colorectal Cancer by Artocarpin, a Dietary Phytochemical from Artocarpus heterophyllus." Journal of Agricultural and Food Chemistry 65, no. 17 (2017): 3474–80. http://dx.doi.org/10.1021/acs.jafc.7b00278.

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20

Sa’diah, Khalimatus, Suripto Dwi Yuwono, Hardoko Insan Qudus, Yandri, and Tati Suhartati. "Isolation, Characterization, Modification of Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.) and Bioactivity Antibacterial Assay of Artocarpin Compound and Their Modification Result." IOP Conference Series: Earth and Environmental Science 537 (August 11, 2020): 012047. http://dx.doi.org/10.1088/1755-1315/537/1/012047.

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21

Shimizu, Makoto, Isao Mizota, and Kana Taniguchi. "Formal Total Synthesis of Artocarpin." HETEROCYCLES 93, no. 1 (2016): 310. http://dx.doi.org/10.3987/com-15-s(t)42.

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22

Mustafa, Haswani Maisarah, Nor Amaiza Mohd Amin, Rabitah Zakaria, et al. "Dual impact of different drying treatments and ethanol/water ratios on antioxidant properties and colour attribute of jackfruit leaves (Artocarpus heterophyllus Lam.) Mastura variety (J35)." BioResources 15, no. 3 (2020): 5122–40. http://dx.doi.org/10.15376/biores.15.3.5122-5140.

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Artocarpus heterophyllus (jackfruit) leaves (JL) are a waste product that is commonly used as livestock feed. Jackfruit leaves have been revealed to possess many medicinal values such as antioxidant and anti-inflammatory properties. In this study, different drying treatments (shade (SD), sun (SN), and oven (OV)) and ethanol/water ratios (E/W) were investigated to evaluate the impact on drying kinetics, color, and antioxidant properties of jackfruit leaves. Results showed that the Newton model was the best fitted mathematical model for the JL drying kinetics. The moisture effective diffusivitie
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23

Pitaksuteepong, Tasana, Atawit Somsiri, and Neti Waranuch. "Targeted transfollicular delivery of artocarpin extract from Artocarpus incisus by means of microparticles." European Journal of Pharmaceutics and Biopharmaceutics 67, no. 3 (2007): 639–45. http://dx.doi.org/10.1016/j.ejpb.2007.03.019.

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24

Zhang, Wen-Jing, Jing-Fang Wu, Peng-Fei Zhou, Yang Wang, and Ai-Jun Hou. "Total syntheses of norartocarpin and artocarpin." Tetrahedron 69, no. 29 (2013): 5850–58. http://dx.doi.org/10.1016/j.tet.2013.05.024.

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25

Walther, E., M. Richter, Z. Xu, et al. "Antipneumococcal activity of neuraminidase inhibiting artocarpin." International Journal of Medical Microbiology 305, no. 3 (2015): 289–97. http://dx.doi.org/10.1016/j.ijmm.2014.12.004.

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26

Akazawa, Hiroyuki, Takuro Shinozaki, Motohiko Ukiya, et al. "Biological Activities of Flavonoids from the Wood Extract of Artocarpus heterophyllus L. (Jackfruit)." Natural Products Journal 10, no. 3 (2020): 216–25. http://dx.doi.org/10.2174/2210315508666181018103353.

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Background: Artocarpus heterophyllus L. (Jackfruit) has been used traditionally as treatment for inflammation and cancer. The aim of this study was to isolate compounds from A. heterophyllus wood extract and evaluate their biological activities such as anti-tumor promoting effect on Epstein-Barr virus early antigen induction, melanogenesis inhibitory activity on the B16 mouse melanoma 4A5 cell line and cytotoxic activity against three human cancer cell lines (HL60, A549, SK-BR-3). Methods: A. heterophyllus wood was extracted with n-hexane and methanol. The ethyl acetate soluble- fraction separ
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27

Arung, Enos Tangke, Britanto Dani Wicaksono, Yohana Ayupriyanti Handoko, et al. "Cytotoxic effect of artocarpin on T47D cells." Journal of Natural Medicines 64, no. 4 (2010): 423–29. http://dx.doi.org/10.1007/s11418-010-0425-6.

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28

Tiraravesit, Narisara, Philippe Humbert, Sophie Robin, Marion Tissot, Céline Viennet, and Jarupa Viyoch. "Artocarpin-enriched (Artocarpus altilis) Heartwood Extract Provides Protection Against UVB-induced Mechanical Damage in Dermal Fibroblasts." Photochemistry and Photobiology 93, no. 5 (2017): 1232–39. http://dx.doi.org/10.1111/php.12788.

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29

Dej-adisai, Sukanya, Kedsaraporn Parndaeng, Chatchai Wattanapiromsakul, and Jae Sung Hwang. "Three New Isoprenylated Flavones from Artocarpus chama Stem and Their Bioactivities." Molecules 27, no. 1 (2021): 3. http://dx.doi.org/10.3390/molecules27010003.

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Phytochemical investigation of Artocarpus chama stem was performed by chromatographic techniques, resulting from the isolation and structure elucidation of three new compounds, namely 3′-farnesyl-apigenin (1), 3-(hydroxyprenyl) isoetin (2), and 3-prenyl-5,7,2′,5′-tetrahydroxy-4′-methoxyflavone (3), and five known compounds, namely homoeriodictyol (4), isocycloartobilo-xanthone (5), artocarpanone (6), naringenin (7), and artocarpin (8). From the screening result, A. chama extract showed a potent tyrosinase inhibitory effect. Ihe isolated compounds 1, 4 and 6 also exhibited tyrosinase inhibition
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Simanjuntak, Helen Anjelina, Nurbaiti Br Singarimbun, Defacto Firmawati Zega, Suharni Pintamas Sinaga, Herlina Simanjuntak, and Toberni S. Situmorang. "Kajian Potensi Tumbuhan Nangka (Artocarpus heterophyllus Lam.) dalam Pengobatan Penyakit Infeksi." Herbal Medicine Journal 5, no. 1 (2022): 1–7. http://dx.doi.org/10.58996/hmj.v5i1.36.

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Infectious diseases are one of the health problems because they cause new infectious diseases caused by antibiotic resistance. So it is necessary to search for new antibiotic agents that are sourced from natural ingredients such as jackfruit plants. Jackfruit plant (Artocarpus heterophyllus Lam.) has many benefits ranging from roots, stems, leaves, fruits and seeds. Jackfruit plant has pharmacological properties as anti-inflammatory, antioxidant, antimalarial, antifungal activity, cytotoxic, tyrosinase inhibitory activity and antimicrobial. The purpose of this study was to determine the study
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31

Jiang, Hua, Xiangcai Meng, Xianbao Shi, and Jingming Yang. "Interspecies metabolic diversity of artocarpin in vitro mammalian liver microsomes." Bioscience, Biotechnology, and Biochemistry 84, no. 4 (2019): 661–69. http://dx.doi.org/10.1080/09168451.2019.1701405.

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32

Shimizu, Kuniyoshi, Ryuichiro Kondo, Kokki Sakai, Norio Takeda, and Tetsuji Nagahata. "The Skin-Lightening Effects of Artocarpin on UVB-Induced Pigmentation." Planta Medica 68, no. 1 (2002): 79–81. http://dx.doi.org/10.1055/s-2002-20057.

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33

Pereira-da-Silva, Gabriela, Maria Cristina Roque-Barreira, and Els J. M. Van Damme. "Artin M: A rational substitution for the names artocarpin and KM+." Immunology Letters 119, no. 1-2 (2008): 114–15. http://dx.doi.org/10.1016/j.imlet.2008.06.002.

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34

Luangpraditkun, Kunlathida, Pensri Charoensit, François Grandmottet, Céline Viennet, and Jarupa Viyoch. "Photoprotective Potential of the Natural Artocarpin against In Vitro UVB-Induced Apoptosis." Oxidative Medicine and Cellular Longevity 2020 (September 19, 2020): 1–17. http://dx.doi.org/10.1155/2020/1042451.

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Apoptosis, a well-known pattern of programmed cell death, occurs in multicellular organisms not only for controlling tissue homeostasis but also for getting rid of severely damaged cells in order to protect the redundant growth of abnormal cells undergoing cancerous cells. The epidermis of the human skin, composed largely of keratinocytes (KCs), is renewed continuously. Therefore, KCs apoptosis plays a critical role in the maintenance of epidermis structure and function. However, regulated cell death can be disturbed by environmental factors especially ultraviolet radiation (UV) B, leading to
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35

Liu, Ju-Fang, Pei-Wen Peng, and Wei-Fang Lee. "Artocarpin, an isoprenyl flavonoid, induced apoptosis and inhibited cell migration in osteosarcoma." Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (2018): PO3–7–19. http://dx.doi.org/10.1254/jpssuppl.wcp2018.0_po3-7-19.

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36

Barre, Annick, Willy J. Peumans, Michel Rossignol, et al. "Artocarpin is a polyspecific jacalin-related lectin with a monosaccharide preference for mannose." Biochimie 86, no. 9-10 (2004): 685–91. http://dx.doi.org/10.1016/j.biochi.2004.09.001.

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Lee, Chiang-Wen, Horng-Huey Ko, Chun-Ching Lin, Chee-Yin Chai, Wan-Tzu Chen, and Feng-Lin Yen. "Artocarpin attenuates ultraviolet B-induced skin damage in hairless mice by antioxidant and anti-inflammatory effect." Food and Chemical Toxicology 60 (October 2013): 123–29. http://dx.doi.org/10.1016/j.fct.2013.07.029.

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38

Lee, Chiang‐Wen, Miao‐Ching Chi, Tsung‐Ming Chang, and Ju‐Fang Liu. "Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species." Journal of Cellular Physiology 234, no. 8 (2018): 13157–68. http://dx.doi.org/10.1002/jcp.27986.

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Bazmi, R. R., and P. Panichayupakaranant. "Synergistic interactions between artocarpin‐rich extract, lawsone methyl ether and ampicillin on anti‐MRSA and their antibiofilm formation." Letters in Applied Microbiology 74, no. 5 (2022): 777–86. http://dx.doi.org/10.1111/lam.13662.

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40

Septama, Abdi Wira, and Pharkphoom Panichayupakaranant. "Synergistic effect of artocarpin on antibacterial activity of some antibiotics against methicillin-resistantStaphylococcus aureus, Pseudomonas aeruginosa, andEscherichia coli." Pharmaceutical Biology 54, no. 4 (2015): 686–91. http://dx.doi.org/10.3109/13880209.2015.1072566.

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Tzeng, Cheng-Wei, Wen-Sheng Tzeng, Liang-Tzung Lin, Chiang-Wen Lee, Feng-Lin Yen, and Chun-Ching Lin. "Enhanced autophagic activity of artocarpin in human hepatocellular carcinoma cells through improving its solubility by a nanoparticle system." Phytomedicine 23, no. 5 (2016): 528–40. http://dx.doi.org/10.1016/j.phymed.2016.02.010.

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42

Qu, Wei, and Xuezheng Liu. "Identification of cytochrome P450 isoforms involved in the metabolism of artocarpin and assessment of its drug-drug interaction." Biomedical Chromatography 32, no. 4 (2018): e4149. http://dx.doi.org/10.1002/bmc.4149.

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Konvipasruang, Ploychompoo, Angsumarn Chandrapatya, and J. W. Jr Amrine. "A new genus and new species of eriophyoid mites (Prostigmata: Eriophyoidea) from Thailand with supplementary description of two species." Systematic and Applied Acarology 24, no. 11 (2019): 1975–87. http://dx.doi.org/10.11158/saa.24.11.1.

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One new genus, one new species, one new record and one new combination of the eriophyoid mites from Thailand were described. They are Rotsukhona loureirii gen. nov., sp. nov. on Tetracera loureiri (Finet & Gagnep.) Pierre ex W. G. Craib, Vareeboona mangiferae (Keifer 1946) new record on Bouea oppositifolia (Roxb.) Adelb and Vimola artocarpae (Mohanasundaram 1981) new combination on Artocarpus heterophyllus Lamarck.
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Rani, P. Geetha, Kiran Bachhawat, G. Bhanuprakash Reddy, Stefan Oscarson, and Avadhesha Surolia. "Isothermal Titration Calorimetric Studies on the Binding of Deoxytrimannoside Derivatives with Artocarpin: Implications for a Deep-Seated Combining Site in Lectins†." Biochemistry 39, no. 35 (2000): 10755–60. http://dx.doi.org/10.1021/bi000744p.

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Rani, P. Geetha, Kiran Bachhawat, G. Bhanuprakash Reddy, Stefan Oscarson, and Avadhesha Surolia. "Isothermal Titration Calorimetric Studies on the Binding of Deoxytrimannoside Derivatives with Artocarpin: Implications for a Deep-Seated Combining Site in Lectins." Biochemistry 39, no. 46 (2000): 14364. http://dx.doi.org/10.1021/bi005117e.

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Sychrová, Alice, Gabriela Škovranová, Marie Čulenová, and Silvia Bittner Fialová. "Prenylated Flavonoids in Topical Infections and Wound Healing." Molecules 27, no. 14 (2022): 4491. http://dx.doi.org/10.3390/molecules27144491.

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The review presents prenylated flavonoids as potential therapeutic agents for the treatment of topical skin infections and wounds, as they can restore the balance in the wound microenvironment. A thorough two-stage search of scientific papers published between 2000 and 2022 was conducted, with independent assessment of results by two reviewers. The main criteria were an MIC (minimum inhibitory concentration) of up to 32 µg/mL, a microdilution/macrodilution broth method according to CLSI (Clinical and Laboratory Standards Institute) or EUCAST (European Committee on Antimicrobial Susceptibility
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Jeyaprakash, A. Arockia, Anand Srivastav, A. Surolia, and M. Vijayan. "Structural Basis for the Carbohydrate Specificities of Artocarpin: Variation in the Length of a Loop as a Strategy for Generating Ligand Specificity." Journal of Molecular Biology 338, no. 4 (2004): 757–70. http://dx.doi.org/10.1016/j.jmb.2004.03.040.

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48

Venil, Chidambaram Kulandaisamy, Nordiana Nordin, Zainul Akmar Zakaria, and Wan Azlina Ahmad. "Chryseobacterium artocarpi sp. nov., isolated from the rhizosphere soil of Artocarpus integer." International Journal of Systematic and Evolutionary Microbiology 64, Pt_9 (2014): 3153–59. http://dx.doi.org/10.1099/ijs.0.063594-0.

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A bacterial strain, designated UTM-3T, isolated from the rhizosphere soil of Artocarpus integer (cempedak) in Malaysia was studied to determine its taxonomic position. Cells were Gram-stain-negative, non-spore-forming rods, devoid of flagella and gliding motility, that formed yellow-pigmented colonies on nutrient agar and contained MK-6 as the predominant menaquinone. Comparative analysis of the 16S rRNA gene sequence of strain UTM-3T with those of the most closely related species showed that the strain constituted a distinct phyletic line within the genus Chryseobacterium with the highest seq
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Panichayupakaranant, Pharkphoom, Abdi Wira Septama, and Akarawat Sinviratpong. "Synergistic activity of lawsone methyl ether in combination with some antibiotics and artocarpin against methicillin-resistant Staphylococcus aureus, Candida albicans, and Trychophyton rubrum." Chinese Herbal Medicines 11, no. 3 (2019): 321–25. http://dx.doi.org/10.1016/j.chmed.2019.06.001.

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Lin, Qin Hua, Jin Bin Yuan, Zhi Lin Ma, et al. "Isoprenylated Flavonoids from Roots of Artocarpus styracifolius." Natural Product Communications 11, no. 12 (2016): 1934578X1601101. http://dx.doi.org/10.1177/1934578x1601101217.

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Abstract:
Seven isoprenylated flavonoids were isolated from Artocarpus styracifolius, including one new triisoprenylated flavone, styracifolin D (1), and six known ones, artocarpone B (2), kuwanon C (3), 6-C-prenyl luteolin (4), albanin A (5), 2,4,2′,4′-tetrahydroxy-3′-(3-methyl-2-butenyl)-chalcone (6), and 3′-[γ-hydroxymethyl-( E)-γ-methylallyl]-2,4,2′,4′-tetrahydroxychalcone 11′- O-coumarate (7). The structures of these compounds were determined by analysis of their spectroscopic and mass spectrometric data. Of them, 3 and 5 exhibited inhibitory effects on cathepsin K with IC50 values of 114.6 and 7.4
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