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Journal articles on the topic 'Artocarpin'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Arung, Enos Tangke, Kuniyoshi Shimizu, and Ryuichiro Kondo. "Artocarpus Plants as a Potential Source of Skin Whitening Agents." Natural Product Communications 6, no. 9 (September 2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600943.

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Artocarpus plants have been a focus of constant attention due to the potential for skin whitening agents. In the in vitro experiment, compounds from the Artocarpus plants, such as artocarpanone, norartocarpetin, artocarpesin, artogomezianol, andalasin, artocarbene, and chlorophorin showed tyrosinase inhibitory activity. Structure-activity investigations revealed that the 4-substituted resorcinol moiety in these compounds was responsible for their potent inhibitory activities on tyrosinase. In the in vitro assay, using B16 melanoma cells, the prenylated polyphenols isolated from Artocarpus plants, such as artocarpin, cudraflavone C, 6-prenylapigenin, kuwanon C, norartocarpin, albanin A, cudraflavone B, and brosimone I showed potent inhibitory activity on melanin formation. Structure-activity investigations revealed that the introduction of an isoprenoid moiety to a non-isoprenoid-substituted polyphenol enhanced the inhibitory activity of melanin production in B16 melanoma cells. In the in vivo investigation, the extract of the wood of Artocarpus incisus and a representative isolated compound from it, artocarpin had a lightening effect on the skin of guinea pigs’ backs. Other in vivo experiments using human volunteers have shown that water extract of Artocarpus lakoocha reduced the melanin formation in the skin of volunteers. These results indicate that the extracts of Artocarpus plants are potential sources for skin whitening agents.

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2

Suhartati, Tati, Khalimatus Sa’diah, Yandri Yandri, and Sutopo Hadi. "Anticancer Activity Study of Modified Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.)." Emerging Science Journal 7, no. 3 (May 3, 2023): 733–43. http://dx.doi.org/10.28991/esj-2023-07-03-05.

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This research is a continuation of the successful isolation of artocarpin from the root of Artocarpus kemando Miq reported in our previous study. In the previous study, the artocarpin was characterized with UV-Vis and FTIR techniques. In this follow-up investigation, the artocarpin was subjected to a transesterification reaction using acetic anhydride and pyridine as catalysts, and the product of the reaction was specified as compound 1. The compound 1 was further characterized with different techniques to gain more complete data and then tested for anticancer activity test against P-388 murine leukemia cells. Characterizations of the compound 1 using 1H-NMR and 13C-NMR techniques suggest that the modification reaction resulted in the conversion of the -OH groups at C2' and 4' at the artocarpin molecule to -OOCH3, and based on the MS analysis, the compound was proposed to have the molecular formula of C30H32O8. Another important feature of compound 1 that should be noted is the significant improvement in stability compared to the unmodified artocarpin. Anticancer activity tests against P-388 murine leukemia cells revealed that compound 1 has an IC50of 2.35 g/mL, confirming that the compound is categorized as an active anticancer agent and suggesting that the compound has promising potential that deserves further investigations. Doi: 10.28991/ESJ-2023-07-03-05 Full Text: PDF

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3

Sell, Ana Maria, and Celso Paulino da Costa. "Effects of plant lectins on in vitro fibroblast proliferation." Brazilian Archives of Biology and Technology 46, no. 3 (June 2003): 349–54. http://dx.doi.org/10.1590/s1516-89132003000300006.

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Lectins are carbohydrate-binding proteins that have been isolated from various sources and presented a wide spectrum of biological activities. The effects of four lectins, namely, Phaseolus vulgaris phytohemagglutinin, PHA, wheat germ agglutinin, WGA, Artocarpus integrifolia seed lectins, jacalin and artocarpin, on in vitro fibroblasts proliferation were investigated. The lectins did not influence the initial cell adhesion to the plate. PHA and WGA at 10-20 µg/mL concentrations significantly decreased fibroblasts proliferation. At these concentrations, they caused morphological alterations on cells and over 80 µg/mL, promoted cell death. Neither jacalin nor artocarpin significantly affected cell proliferation.

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4

Septama, Abdi Wira, and Eldiza Puji Rahmi, M.Sc. "SYNERGISTIC EFFECT OF COMBINATION BETWEEN CYANOMACLURIN AND ARTOCARPIN FROM ARTOCARPUS HETEROPHYLLUS HEARTWOODS AGAINSTS STREPTOCOCCUS PYOGENES AND STAPHYLOCOCCUS EPIDERMIDIS." Journal of Research in Pharmacy and Pharmaceutical Sciences 1, no. 1 (June 27, 2022): 21–25. http://dx.doi.org/10.33533/jrpps.v1i1.4250.

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Streptococcus pyogenes and Staphylococcus epidermidis are major problem of human health and may generate antibacterial resistance problem. Flavonoid has been used for the treatment of several ailments including bacterial infection. Artocarpus heterophyllus is a potential source of flavonoid compounds such as artocarpin and cyanomaclurin. The study was conducted to observe synergistic effects between flavonoid compounds against S. pyogenes and S. epidermidis. The antibacterial activity of combination of artocarpin and cyanomaclurin isolated from A. heterophyllus heartwoods were evaluated against S. pyogenes and S. epidermidis using broth microdilution methods. Interaction between two compounds in combination was determined using checkerboard assay. Artocarpin showed strong antibacterial activity with MIC value of 1.9 µg/mL. Cyanomaclurin only exhibited moderate activity with MIC value of 15.6 µg/mL. The mixture of compounds in several ratios tended to increase antibacterial activities of cyanomaclurin. There is no antagonistic effect when compounds used together. It can be concluded that flavonoid compounds in combination may enhance antibacterial activity to prevent development of antibacterial resistance.

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5

Suhartati, Tati, Eka Epriyanti, Inggit Borisha, Yandri, Jhons F. Suwandi, Suripto D. Yuwono, Hardoko I. Qudus, and Sutopo Hadi. "In Vivo Antimalarial Test of Artocarpin and in vitro Antimalarial Test of Artonin M Isolated from Artocarpus." Revista de Chimie 71, no. 5 (May 29, 2020): 400–408. http://dx.doi.org/10.37358/rc.20.5.8150.

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The derivative of flavonoid compounds, artocarpin (1) and artonin M (2), were isolated from the root wood of Artocarpus altilis and from the root bark of A. kemando, respectively. Both plants originated from Lampung, Indonesia. The structure of the two compounds has been carefully determined by physical method and spectroscopy techniques of UV, IR, and NMR. The in vivo antimalarial test of artocarpin showed very good Plasmodium activity in female mice, with ED50 value of 34.88 mg/kg body weight (kgBW), whereas the in vitro antimalarial test of artonin M showed very strong activity with IC50 of 0.3 μg/mL (5.967 x 10-7 M).

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6

Chowdhury, S., H. Ahmed, and B. P. Chatterjee. "Chemical modification studies of Artocarpus lakoocha lectin artocarpin." Biochimie 73, no. 5 (May 1991): 563–71. http://dx.doi.org/10.1016/0300-9084(91)90024-u.

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7

Hu, Stephen Chu-Sung, Chi-Ling Lin, Hui-Min Cheng, Gwo-Shing Chen, Chiang-Wen Lee, and Feng-Lin Yen. "Artocarpin Induces Apoptosis in Human Cutaneous Squamous Cell Carcinoma HSC-1 Cells and Its Cytotoxic Activity Is Dependent on Protein-Nutrient Concentration." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/236159.

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Artocarpin, a natural prenylated flavonoid, has been shown to have various biological properties. However, its effects on human cutaneous squamous cell carcinoma (SCC) have not been previously investigated. We set out to determine whether artocarpin has cytotoxic effects on SCC cells and whether its pharmacological activity is dependent on protein-nutrient concentration. Our results showed that treatment of HSC-1 cells (a human cutaneous SCC cell line) with artocarpin decreased cell viability and induced cell apoptosis by increasing caspase 3/7 activity. These effects were more pronounced at low fetal bovine serum (FBS) concentrations. Artocarpin induced an increase in the level of phospho-p38 and a decrease in the levels of phospho-ERK, phospho-JNK, phospho-Akt, phospho-mTOR, and phospho-S6K. High FBS concentrations in the culture media inhibited and delayed the uptake of artocarpin from the extracellular compartment (culture media) into the intracellular compartment, as determined by high performance liquid chromatography (HPLC) analysis. In conclusion, artocarpin induces apoptosis in HSC-1 cells through modulation of MAPK and Akt/mTOR pathways. Binding of artocarpin to proteins in the FBS may inhibit cellular uptake and reduce the cytotoxic activity of artocarpin on HSC-1 cells. Therefore, artocarpin may have potential use in the future as a form of treatment for cutaneous SCC.

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8

Suresh, S., P. G. Rani, J. V. Pratap, R. Sankaranarayanan, A. Surolia, and M. Vijayan. "Homology between jacalin and artocarpin from jackfruit (Artocarpus integrifolia) seeds. Partial sequence and preliminary crystallographic studies of artocarpin." Acta Crystallographica Section D Biological Crystallography 53, no. 4 (July 1, 1997): 469–71. http://dx.doi.org/10.1107/s0907444997000851.

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9

Chowdhury, Sunanda, and Bishnu P. Charterjee. "Artocarpin-galactomannan interaction: Characterization of combining site of artocarpin." Phytochemistry 32, no. 2 (January 1993): 243–49. http://dx.doi.org/10.1016/s0031-9422(00)94975-6.

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10

Nonpanya, Nongyao, Kittipong Sanookpan, Nicharat Sriratanasak, Chanida Vinayanuwattikun, Duangdao Wichadakul, Boonchoo Sritularak, and Pithi Chanvorachote. "Artocarpin Targets Focal Adhesion Kinase-Dependent Epithelial to Mesenchymal Transition and Suppresses Migratory-Associated Integrins in Lung Cancer Cells." Pharmaceutics 13, no. 4 (April 14, 2021): 554. http://dx.doi.org/10.3390/pharmaceutics13040554.

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Focal adhesion kinase (FAK) controls several cancer aggressive potentials of cell movement and dissemination. As epithelial–mesenchymal transition (EMT) and the migratory-associated integrins, known influencers of metastasis, have been found to be linked with FAK activity, this study unraveled the potential pharmacological effect of artocarpin in targeting FAK resulting in the suppression of EMT and migratory behaviors of lung cancer cells. Treatment with artocarpin was applied at concentrations of 0–10 μM, and the results showed non-cytotoxicity in lung cancer cell lines (A549 and H460), normal lung (BEAS-2B) cells and primary metastatic lung cancer cells (ELC12, ELC16, and ELC20). We also found that artocarpin (0–10 µM) had no effect on cell viability, proliferation, and migration in BEAS-2B cells. For metastasis-related approaches, artocarpin significantly inhibited cell migration, invasion, and filopodia formation. Artocarpin also dramatically suppressed anchorage-independent growth, cancer stem cell (CSC) spheroid formation, and viability of CSC-rich spheroids. For molecular targets of artocarpin action, computational molecular docking revealed that artocarpin had the best binding affinity of −8.0 kcal/mol with FAK protein. Consistently, FAK-downstream proteins, namely active Akt (phosphorylated Akt), active mTOR (phosphorylated mTOR), and Cdc42, and EMT marker and transcription factor (N-cadherin, Vimentin, and Slug), were found to be significantly depleted in response to artocarpin treatment. Furthermore, we found the decrease of Caveolin-1 (Cav-1) accompanied by the reduction of integrin-αν and integrin-β3. Taken together, these findings support the anti-metastasis potentials of the compound to be further developed for cancer therapy.

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11

Lathiff, Siti Mariam Abdul, Noraini Jemaon, Siti Awanis Abdullah, and Shajarahtunnur Jamil. "Flavonoids from Artocarpus anisophyllus and their Bioactivities." Natural Product Communications 10, no. 3 (March 2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000305.

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Two new prenylated flavonoids, 4′,5-dihydroxy-6,7-(2,2-dimethylpyrano)-2′-methoxy-8-γ,γ-dimethylallylflavone 1 and 3′-hydroxycycloartocarpin 2 along with six known flavonoids, 5,7-dihydroxy-4′-methoxy-8-prenylflavanone 3, isobavachalcone 4, pyranocycloartobiloxanthone A 5, artocarpin 6, chaplashin 7 and cycloartocarpin 8 were isolated for the first time from the leaves and the heartwoods of Artocarpus anisophyllus Miq. The structures of isolated flavonoids were elucidated spectroscopically using 1D and 2D NMR, FTIR, MS, UV and also by comparison with literature data. These flavonoids were screened for their antioxidant and tyrosinase inhibitory activities. The dichloromethane and ethyl acetate crude extracts together with 3′-hydroxycycloartocarpin 2, pyranocycloartobiloxanthone A 5 and artocarpin 6 showed DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity with SC50 values of 80.2, 40.0, 152.9, 20.2 and 140.0 μg/mL in 30 min, respectively. Pyranocycloartobiloxanthone A 5 exhibited significant tyrosinase inhibitory activity against tyrosinase from mushroom with IC50 values of 60.5 μg/mL.

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12

Chantrapromma, Suchada, Nawong Boonnak, Hoong-Kun Fun, and Chatchanok Karalai. "Artocarpin dichloromethane hemisolvate." Acta Crystallographica Section E Structure Reports Online 63, no. 4 (March 22, 2007): o1864—o1866. http://dx.doi.org/10.1107/s1600536807011646.

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13

Preud'homme, J. L., P. Aucouturier, and N. Gualde. "Jacalin and artocarpin." Journal of Immunological Methods 146, no. 2 (January 1992): 259–60. http://dx.doi.org/10.1016/0022-1759(92)90236-m.

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14

Septama, AbdiWira, Nordin Simbak, Nik NurulNajihah Nik Mat Daud, and EldizaPuji Rahmi. "The phytochemical and pharmacological properties of artocarpin from Artocarpus heterophyllus." Asian Pacific Journal of Tropical Medicine 13, no. 1 (2020): 1. http://dx.doi.org/10.4103/1995-7645.273567.

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15

Chatterjee, Bishnu P., Hafiz Ahmed, and Sunanda Chowdhury. "Further characterization of Artocarpus lakoocha lectin (artocarpin) purified using rivanol." Carbohydrate Research 180, no. 1 (September 1988): 97–110. http://dx.doi.org/10.1016/0008-6215(88)80067-3.

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16

Tzeng, Cheng-Wei, Feng-Lin Yen, Liang-Tzung Lin, Chiang-Wen Lee, Ming-Hong Yen, Wen-Sheng Tzeng, and Chun-Ching Lin. "Antihepatoma Activity ofArtocarpus communisIs Higher in Fractions with High Artocarpin Content." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/978525.

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Extracts from natural plants have been used in traditional medicine for many centuries worldwide.Artocarpus communisis one such plant that has been used to treat liver cirrhosis, hypertension, and diabetes. To our knowledge, this study is the first to investigate the antihepatoma activity ofA. communistoward HepG2 and PLC/PRF/5 cells and the first to explore the relationship between antihepatoma activity and the active compound artocarpin content in different fractions ofA. communis.A. communismethanol extract and fractions induced dose-dependent reduction of tumor cell viability. DNA laddering analysis revealed thatA. communisextract and fractions did not induce apoptosis in HepG2 and PLC/PRF/5 cells. Instead, acridine orange staining revealed thatA. communistriggered autophagic cell death in a dose-dependent manner. The antihepatoma activity ofA. communisis attributable to artocarpin. The fractions with the highest artocarpin content were also the fractions with the highest antihepatoma activity in the following order: dichloromethane fraction > methanol extract > ethyl acetate fraction >n-butanol fraction >n-hexane fraction. Taken together,A. communisshowed antihepatoma activity through autophagic cell death. The effect was related to artocarpin content. Artocarpin could be considered an indicator of the anticancer potential ofA. communisextract.

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17

Chiang Chan, Eric Wei, Siu Kuin Wong, Joseph Tangah, and Hung Tuck Chan. "Chemistry and Pharmacology of Artocarpin: An Isoprenyl Flavone from Artocarpus Species." Systematic Reviews in Pharmacy 9, no. 1 (July 31, 2018): 58–63. http://dx.doi.org/10.5530/srp.2018.1.12.

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18

Luangpraditkun, Kunlathida, Marion Tissot, Anupong Joompang, Pensri Charoensit, François Grandmottet, Jarupa Viyoch, and Céline Viennet. "Prevention by the Natural Artocarpin of Morphological and Biochemical Alterations on UVB-Induced HaCaT Cells." Oxidative Medicine and Cellular Longevity 2021 (July 6, 2021): 1–13. http://dx.doi.org/10.1155/2021/5067957.

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Natural substances have gained considerable attention for skin protection against UV light reactions. Artocarpus altilis plant’s heartwood extract is comprised of artocarpin as a major substance, already known for its interesting biological attributes as an antimicrobial, an anti-inflammatory, an antioxidant, and a melanogenesis inhibitor. The present work clarified the mechanism of natural artocarpin (NAR) with a purity of approximately 99% against the effects of UVB-induced HaCaT keratinocyte apoptosis. The indicated results showed that NAR suppresses free radical production (ROS and nitrite) and apoptosis-related molecule activation (caspase-3, p-p53, p-p38, and NF-κB p65) and secretion (TNF-α). Additionally, NAR prevented structural damages (nuclei condensation and fragmentation, apoptotic body formation, impaired cell adherence and round cell shape, disruption of F-actin filament, and clustering of cell death receptor CD95/Fas) and biophysical changes (plasma membrane rigidification). Thus, NAR acts directly from scavenging free radicals generated by UV and indirectly by suppressing morphological and biochemical UV-induced cell damages. Its biological effects are mainly attributed to antioxidant and antiapoptotic properties. Taken together, NAR could be considered as an effective natural product for photoprotective formulations.

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19

Sun, Guochuan, Zongping Zheng, Mee-Hyun Lee, Yijuan Xu, Soouk Kang, Zigang Dong, Mingfu Wang, Zhennan Gu, Haitao Li, and Wei Chen. "Chemoprevention of Colorectal Cancer by Artocarpin, a Dietary Phytochemical from Artocarpus heterophyllus." Journal of Agricultural and Food Chemistry 65, no. 17 (April 18, 2017): 3474–80. http://dx.doi.org/10.1021/acs.jafc.7b00278.

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20

Sa’diah, Khalimatus, Suripto Dwi Yuwono, Hardoko Insan Qudus, Yandri, and Tati Suhartati. "Isolation, Characterization, Modification of Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.) and Bioactivity Antibacterial Assay of Artocarpin Compound and Their Modification Result." IOP Conference Series: Earth and Environmental Science 537 (August 11, 2020): 012047. http://dx.doi.org/10.1088/1755-1315/537/1/012047.

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21

Shimizu, Makoto, Isao Mizota, and Kana Taniguchi. "Formal Total Synthesis of Artocarpin." HETEROCYCLES 93, no. 1 (2016): 310. http://dx.doi.org/10.3987/com-15-s(t)42.

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22

Mustafa, Haswani Maisarah, Nor Amaiza Mohd Amin, Rabitah Zakaria, Mohd Shamsul Anuar, Azhari Samsu Baharuddin, Halimatun Saadiah Hafid, and Farah Nadia Omar. "Dual impact of different drying treatments and ethanol/water ratios on antioxidant properties and colour attribute of jackfruit leaves (Artocarpus heterophyllus Lam.) Mastura variety (J35)." BioResources 15, no. 3 (May 15, 2020): 5122–40. http://dx.doi.org/10.15376/biores.15.3.5122-5140.

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Artocarpus heterophyllus (jackfruit) leaves (JL) are a waste product that is commonly used as livestock feed. Jackfruit leaves have been revealed to possess many medicinal values such as antioxidant and anti-inflammatory properties. In this study, different drying treatments (shade (SD), sun (SN), and oven (OV)) and ethanol/water ratios (E/W) were investigated to evaluate the impact on drying kinetics, color, and antioxidant properties of jackfruit leaves. Results showed that the Newton model was the best fitted mathematical model for the JL drying kinetics. The moisture effective diffusivities ranged from 2.920 × 10-10 to 6.814 × 10-10 m2/s over the temperature range studied. Shade drying was able to preserve the green pigment better than OV and SN drying treatments. Treatment with ethanol/water ratio at 80% and oven-dried (OV80) revealed the highest phenolic content (195.05 ± 1.21 mg gallic acid equivalent (GAE)/g extract weight (EW)), flavonoid content (11.02 ± 0.17 mg artocarpin equivalent (AE)/g EW), and antioxidant activities (90% scavenging activity and reducing power of 1043.84 ± 5.28 µM trolox equivalent (TE)/g EW) compared to SD and SN treatments. The OV80 also possessed the highest artocarpin, squalene, and β-sitosterol contents determined. The OV80 was selected for improving antioxidant and colour stability, and has the potential to be developed into functional biopolymer production.

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23

Pitaksuteepong, Tasana, Atawit Somsiri, and Neti Waranuch. "Targeted transfollicular delivery of artocarpin extract from Artocarpus incisus by means of microparticles." European Journal of Pharmaceutics and Biopharmaceutics 67, no. 3 (November 2007): 639–45. http://dx.doi.org/10.1016/j.ejpb.2007.03.019.

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24

Zhang, Wen-Jing, Jing-Fang Wu, Peng-Fei Zhou, Yang Wang, and Ai-Jun Hou. "Total syntheses of norartocarpin and artocarpin." Tetrahedron 69, no. 29 (July 2013): 5850–58. http://dx.doi.org/10.1016/j.tet.2013.05.024.

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25

Walther, E., M. Richter, Z. Xu, C. Kramer, S. von Grafenstein, J. Kirchmair, U. Grienke, et al. "Antipneumococcal activity of neuraminidase inhibiting artocarpin." International Journal of Medical Microbiology 305, no. 3 (May 2015): 289–97. http://dx.doi.org/10.1016/j.ijmm.2014.12.004.

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26

Akazawa, Hiroyuki, Takuro Shinozaki, Motohiko Ukiya, Toshihiro Akihisa, Manosroi Jiradej, Harukuni Tokuda, and Makoto Fukatsu. "Biological Activities of Flavonoids from the Wood Extract of Artocarpus heterophyllus L. (Jackfruit)." Natural Products Journal 10, no. 3 (June 16, 2020): 216–25. http://dx.doi.org/10.2174/2210315508666181018103353.

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Background: Artocarpus heterophyllus L. (Jackfruit) has been used traditionally as treatment for inflammation and cancer. The aim of this study was to isolate compounds from A. heterophyllus wood extract and evaluate their biological activities such as anti-tumor promoting effect on Epstein-Barr virus early antigen induction, melanogenesis inhibitory activity on the B16 mouse melanoma 4A5 cell line and cytotoxic activity against three human cancer cell lines (HL60, A549, SK-BR-3). Methods: A. heterophyllus wood was extracted with n-hexane and methanol. The ethyl acetate soluble- fraction separated from the methanol extract was separated and purified with column chromatography to isolate compounds. The structures of isolated compounds were elucidated with spectroscopic methods. These compounds were evaluated for their biological activities. Results: Thirteen known compounds including four prenylflavonoids were isolated from the wood extracts. Nine flavonoids (2, 3, 5-11) exhibited potent anti-tumor promoting activity with IC50 values of 259-296 molar ratio / 32 pmol TPA. Two flavonoids, Norartocarpetin (6) at concentration of 30 μM and cyanomaclurin (11) at the concentration of 100 μM showed melanin content value of 47.6 % and 80.1 %, respectively. Two prenylflavonoids, cudraflavone B (2) and artocarpin (5), showed cytotoxicity against the human cancer cell lines tested. Cudraflavone B (2) showed cytotoxicity against all three human cancer cell lines whereas artocarpin (5) only exhibited cytotoxicity against two out three cell lines testes. The IC50 values were comparable to or better than cisplatin. Conclusion: From the view point of structure activity relationships of the flavonoids isolated, side chains such as prenyl and 3-methyl-1-butenyl moiety were key for their potent biological activities.

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Arung, Enos Tangke, Britanto Dani Wicaksono, Yohana Ayupriyanti Handoko, Irawan Wijaya Kusuma, Kuniyoshi Shimizu, Dina Yulia, and Ferry Sandra. "Cytotoxic effect of artocarpin on T47D cells." Journal of Natural Medicines 64, no. 4 (June 11, 2010): 423–29. http://dx.doi.org/10.1007/s11418-010-0425-6.

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28

Tiraravesit, Narisara, Philippe Humbert, Sophie Robin, Marion Tissot, Céline Viennet, and Jarupa Viyoch. "Artocarpin-enriched (Artocarpus altilis) Heartwood Extract Provides Protection Against UVB-induced Mechanical Damage in Dermal Fibroblasts." Photochemistry and Photobiology 93, no. 5 (July 25, 2017): 1232–39. http://dx.doi.org/10.1111/php.12788.

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Dej-adisai, Sukanya, Kedsaraporn Parndaeng, Chatchai Wattanapiromsakul, and Jae Sung Hwang. "Three New Isoprenylated Flavones from Artocarpus chama Stem and Their Bioactivities." Molecules 27, no. 1 (December 21, 2021): 3. http://dx.doi.org/10.3390/molecules27010003.

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Phytochemical investigation of Artocarpus chama stem was performed by chromatographic techniques, resulting from the isolation and structure elucidation of three new compounds, namely 3′-farnesyl-apigenin (1), 3-(hydroxyprenyl) isoetin (2), and 3-prenyl-5,7,2′,5′-tetrahydroxy-4′-methoxyflavone (3), and five known compounds, namely homoeriodictyol (4), isocycloartobilo-xanthone (5), artocarpanone (6), naringenin (7), and artocarpin (8). From the screening result, A. chama extract showed a potent tyrosinase inhibitory effect. Ihe isolated compounds 1, 4 and 6 also exhibited tyrosinase inhibition with IC50 of 135.70, 52.18, and 38.78 µg/mL, respectively. Moreover, compounds 3, 4, 5, 6, and 8 showed strong activity against Staphylococcus epidermidis, S. aureus, methicillin-resistant S. aureus, and Cutibacterium acnes. This study is the first report on phytochemical investigation with new compounds and biological activities of A. chama. Skin infection can cause dark spots or hyperpigmentation. The isolated compounds that showed both anityrosinase and antimicrobial activities will be further studied in in vivo and clinical trials in order to develop treatment for hyperpigmentation, which is caused by infectious diseases by microorganisms.

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Simanjuntak, Helen Anjelina, Nurbaiti Br Singarimbun, Defacto Firmawati Zega, Suharni Pintamas Sinaga, Herlina Simanjuntak, and Toberni S. Situmorang. "Kajian Potensi Tumbuhan Nangka (Artocarpus heterophyllus Lam.) dalam Pengobatan Penyakit Infeksi." Herbal Medicine Journal 5, no. 1 (February 22, 2022): 1–7. http://dx.doi.org/10.58996/hmj.v5i1.36.

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Infectious diseases are one of the health problems because they cause new infectious diseases caused by antibiotic resistance. So it is necessary to search for new antibiotic agents that are sourced from natural ingredients such as jackfruit plants. Jackfruit plant (Artocarpus heterophyllus Lam.) has many benefits ranging from roots, stems, leaves, fruits and seeds. Jackfruit plant has pharmacological properties as anti-inflammatory, antioxidant, antimalarial, antifungal activity, cytotoxic, tyrosinase inhibitory activity and antimicrobial. The purpose of this study was to determine the study of jackfruit plants that have potential as antimicrobials. The research method was carried out using a literature review with online media based on the Web, Scopus, PubMed, Science Direct, ResearchGate, Google Scholar used for publication. The results showed that jackfruit has antimicrobial activity due to the content of bioactive compounds such as: tannins, flavonoids, catechins, artocarpin and artocarpanone. Jackfruit plant parts that have the potential as antimicrobials are the leaves, jackfruit skin, seeds and roots. Jackfruit plants have potential as antimicrobials against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Propionibacterium acnes, Klebsiella pneumonia, Pseudomonas aeruginosa, Streptococcus mutans, Mycobacterium tuberculosis, Plasmodium falciparum, and Vibrio cholera.

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Jiang, Hua, Xiangcai Meng, Xianbao Shi, and Jingming Yang. "Interspecies metabolic diversity of artocarpin in vitro mammalian liver microsomes." Bioscience, Biotechnology, and Biochemistry 84, no. 4 (December 12, 2019): 661–69. http://dx.doi.org/10.1080/09168451.2019.1701405.

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Shimizu, Kuniyoshi, Ryuichiro Kondo, Kokki Sakai, Norio Takeda, and Tetsuji Nagahata. "The Skin-Lightening Effects of Artocarpin on UVB-Induced Pigmentation." Planta Medica 68, no. 1 (January 2002): 79–81. http://dx.doi.org/10.1055/s-2002-20057.

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Pereira-da-Silva, Gabriela, Maria Cristina Roque-Barreira, and Els J. M. Van Damme. "Artin M: A rational substitution for the names artocarpin and KM+." Immunology Letters 119, no. 1-2 (August 2008): 114–15. http://dx.doi.org/10.1016/j.imlet.2008.06.002.

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Luangpraditkun, Kunlathida, Pensri Charoensit, François Grandmottet, Céline Viennet, and Jarupa Viyoch. "Photoprotective Potential of the Natural Artocarpin against In Vitro UVB-Induced Apoptosis." Oxidative Medicine and Cellular Longevity 2020 (September 19, 2020): 1–17. http://dx.doi.org/10.1155/2020/1042451.

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Apoptosis, a well-known pattern of programmed cell death, occurs in multicellular organisms not only for controlling tissue homeostasis but also for getting rid of severely damaged cells in order to protect the redundant growth of abnormal cells undergoing cancerous cells. The epidermis of the human skin, composed largely of keratinocytes (KCs), is renewed continuously. Therefore, KCs apoptosis plays a critical role in the maintenance of epidermis structure and function. However, regulated cell death can be disturbed by environmental factors especially ultraviolet radiation (UV) B, leading to the formation of sunburn cells (KCs undergoing UVB-induced apoptosis) and impairing the skin integrity. In the present study, we firstly reported the potential of the natural artocarpin (NAR) to regulate UVB-induced human KCs apoptosis. The NAR showed antilipid peroxidation with an IC50 value of 18.2±1.6 μg/mL, according to TBARS assay while the IC50 value of trolox, a well-known antioxidant, was 7.3±0.8 μg/mL. For cell-based studies, KCs were pretreated with 3.1 μg/mL of the NAR for 24 hr and then exposed to UVB at 55 mJ/cm2. Our data indicated that the NAR pretreatment reduces UVB-induced oxidative stress by scavenging free radicals and nitric oxide and therefore prevents reactive oxygen species (ROS) and reactive nitrogen species- (RNS-) mediated apoptosis. The NAR pretreatment has been shown also to reduce the UVB-induced cyclobutane pyrimidine dimer (CPD) lesions by absorbing UVB radiation and regulating the cell cycle phase. Additionally, the NAR pretreatment was found to modulate the expression of cleaved caspases-3 and 8 that trigger different signalling cascades leading to apoptosis. Thus, these results provide a basis for the investigation of the photoprotective effect of the NAR isolated from A. altilis heartwood and suggest that it can be potentially used as an agent against UVB-induced skin damages.

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Liu, Ju-Fang, Pei-Wen Peng, and Wei-Fang Lee. "Artocarpin, an isoprenyl flavonoid, induced apoptosis and inhibited cell migration in osteosarcoma." Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (2018): PO3–7–19. http://dx.doi.org/10.1254/jpssuppl.wcp2018.0_po3-7-19.

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36

Barre, Annick, Willy J. Peumans, Michel Rossignol, Gisèle Borderies, Raphaël Culerrier, Els J. M. Van Damme, and Pierre Rougé. "Artocarpin is a polyspecific jacalin-related lectin with a monosaccharide preference for mannose." Biochimie 86, no. 9-10 (September 2004): 685–91. http://dx.doi.org/10.1016/j.biochi.2004.09.001.

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37

Lee, Chiang-Wen, Horng-Huey Ko, Chun-Ching Lin, Chee-Yin Chai, Wan-Tzu Chen, and Feng-Lin Yen. "Artocarpin attenuates ultraviolet B-induced skin damage in hairless mice by antioxidant and anti-inflammatory effect." Food and Chemical Toxicology 60 (October 2013): 123–29. http://dx.doi.org/10.1016/j.fct.2013.07.029.

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38

Lee, Chiang‐Wen, Miao‐Ching Chi, Tsung‐Ming Chang, and Ju‐Fang Liu. "Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species." Journal of Cellular Physiology 234, no. 8 (December 13, 2018): 13157–68. http://dx.doi.org/10.1002/jcp.27986.

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39

Bazmi, R. R., and P. Panichayupakaranant. "Synergistic interactions between artocarpin‐rich extract, lawsone methyl ether and ampicillin on anti‐MRSA and their antibiofilm formation." Letters in Applied Microbiology 74, no. 5 (February 8, 2022): 777–86. http://dx.doi.org/10.1111/lam.13662.

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40

Septama, Abdi Wira, and Pharkphoom Panichayupakaranant. "Synergistic effect of artocarpin on antibacterial activity of some antibiotics against methicillin-resistantStaphylococcus aureus, Pseudomonas aeruginosa, andEscherichia coli." Pharmaceutical Biology 54, no. 4 (October 2015): 686–91. http://dx.doi.org/10.3109/13880209.2015.1072566.

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41

Tzeng, Cheng-Wei, Wen-Sheng Tzeng, Liang-Tzung Lin, Chiang-Wen Lee, Feng-Lin Yen, and Chun-Ching Lin. "Enhanced autophagic activity of artocarpin in human hepatocellular carcinoma cells through improving its solubility by a nanoparticle system." Phytomedicine 23, no. 5 (May 2016): 528–40. http://dx.doi.org/10.1016/j.phymed.2016.02.010.

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42

Qu, Wei, and Xuezheng Liu. "Identification of cytochrome P450 isoforms involved in the metabolism of artocarpin and assessment of its drug-drug interaction." Biomedical Chromatography 32, no. 4 (January 12, 2018): e4149. http://dx.doi.org/10.1002/bmc.4149.

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43

Konvipasruang, Ploychompoo, Angsumarn Chandrapatya, and J. W. Jr Amrine. "A new genus and new species of eriophyoid mites (Prostigmata: Eriophyoidea) from Thailand with supplementary description of two species." Systematic and Applied Acarology 24, no. 11 (November 7, 2019): 1975–87. http://dx.doi.org/10.11158/saa.24.11.1.

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One new genus, one new species, one new record and one new combination of the eriophyoid mites from Thailand were described. They are Rotsukhona loureirii gen. nov., sp. nov. on Tetracera loureiri (Finet & Gagnep.) Pierre ex W. G. Craib, Vareeboona mangiferae (Keifer 1946) new record on Bouea oppositifolia (Roxb.) Adelb and Vimola artocarpae (Mohanasundaram 1981) new combination on Artocarpus heterophyllus Lamarck.

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44

Rani, P. Geetha, Kiran Bachhawat, G. Bhanuprakash Reddy, Stefan Oscarson, and Avadhesha Surolia. "Isothermal Titration Calorimetric Studies on the Binding of Deoxytrimannoside Derivatives with Artocarpin: Implications for a Deep-Seated Combining Site in Lectins†." Biochemistry 39, no. 35 (September 2000): 10755–60. http://dx.doi.org/10.1021/bi000744p.

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45

Rani, P. Geetha, Kiran Bachhawat, G. Bhanuprakash Reddy, Stefan Oscarson, and Avadhesha Surolia. "Isothermal Titration Calorimetric Studies on the Binding of Deoxytrimannoside Derivatives with Artocarpin: Implications for a Deep-Seated Combining Site in Lectins." Biochemistry 39, no. 46 (November 2000): 14364. http://dx.doi.org/10.1021/bi005117e.

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46

Sychrová, Alice, Gabriela Škovranová, Marie Čulenová, and Silvia Bittner Fialová. "Prenylated Flavonoids in Topical Infections and Wound Healing." Molecules 27, no. 14 (July 13, 2022): 4491. http://dx.doi.org/10.3390/molecules27144491.

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The review presents prenylated flavonoids as potential therapeutic agents for the treatment of topical skin infections and wounds, as they can restore the balance in the wound microenvironment. A thorough two-stage search of scientific papers published between 2000 and 2022 was conducted, with independent assessment of results by two reviewers. The main criteria were an MIC (minimum inhibitory concentration) of up to 32 µg/mL, a microdilution/macrodilution broth method according to CLSI (Clinical and Laboratory Standards Institute) or EUCAST (European Committee on Antimicrobial Susceptibility Testing), pathogens responsible for skin infections, and additional antioxidant, anti-inflammatory, and low cytotoxic effects. A total of 127 structurally diverse flavonoids showed promising antimicrobial activity against pathogens affecting wound healing, predominantly Staphylococcus aureus strains, but only artocarpin, diplacone, isobavachalcone, licochalcone A, sophoraflavanone G, and xanthohumol showed multiple activity, including antimicrobial, antioxidant, and anti-inflammatory along with low cytotoxicity important for wound healing. Although prenylated flavonoids appear to be promising in wound therapy of humans, and also animals, their activity was measured only in vitro and in vivo. Future studies are, therefore, needed to establish rational dosing according to MIC and MBC (minimum bactericidal concentration) values, test potential toxicity to human cells, measure healing kinetics, and consider formulation in smart drug release systems and/or delivery technologies to increase their bioavailability.

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Jeyaprakash, A. Arockia, Anand Srivastav, A. Surolia, and M. Vijayan. "Structural Basis for the Carbohydrate Specificities of Artocarpin: Variation in the Length of a Loop as a Strategy for Generating Ligand Specificity." Journal of Molecular Biology 338, no. 4 (May 2004): 757–70. http://dx.doi.org/10.1016/j.jmb.2004.03.040.

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48

Venil, Chidambaram Kulandaisamy, Nordiana Nordin, Zainul Akmar Zakaria, and Wan Azlina Ahmad. "Chryseobacterium artocarpi sp. nov., isolated from the rhizosphere soil of Artocarpus integer." International Journal of Systematic and Evolutionary Microbiology 64, Pt_9 (September 1, 2014): 3153–59. http://dx.doi.org/10.1099/ijs.0.063594-0.

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A bacterial strain, designated UTM-3T, isolated from the rhizosphere soil of Artocarpus integer (cempedak) in Malaysia was studied to determine its taxonomic position. Cells were Gram-stain-negative, non-spore-forming rods, devoid of flagella and gliding motility, that formed yellow-pigmented colonies on nutrient agar and contained MK-6 as the predominant menaquinone. Comparative analysis of the 16S rRNA gene sequence of strain UTM-3T with those of the most closely related species showed that the strain constituted a distinct phyletic line within the genus Chryseobacterium with the highest sequence similarities to Chryseobacterium lactis NCTC 11390T, Chryseobacterium viscerum 687B-08T, Chryseobacterium tructae 1084-08T, Chryseobacterium arthrosphaerae CC-VM-7T, Chryseobacterium oncorhynchi 701B-08T, Chryseobacterium vietnamense GIMN1.005T, Chryseobacterium bernardetii NCTC 13530T, Chryseobacterium nakagawai NCTC 13529T, Chryseobacterium gallinarum LMG 27808T, Chryseobacterium culicis R4-1AT, Chryseobacterium flavum CW-E2T, Chryseobacterium aquifrigidense CW9T, Chryseobacterium ureilyticum CCUG 52546T, Chryseobacterium indologenes NBRC 14944T, Chryseobacterium gleum CCUG 14555T, Chryseobacterium jejuense JS17-8T, Chryseobacterium oranimense H8T and Chryseobacterium joostei LMG 18212T. The major whole-cell fatty acids were iso-C15 : 0 and iso-C17 : 1ω9c, followed by summed feature 4 (iso-C15 : 0 2-OH and/or C16 : 1ω7t) and iso-C17 : 0 3-OH, and the polar lipid profile consisted of phosphatidylethanolamine and several unknown lipids. The DNA G+C content strain UTM-3T was 34.8 mol%. On the basis of the phenotypic and phylogenetic evidence, it is concluded that the isolate represents a novel species of the genus Chryseobacterium , for which the name Chryseobacterium artocarpi sp. nov. is proposed. The type strain is UTM-3T ( = CECT 8497T = KCTC 32509T).

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Panichayupakaranant, Pharkphoom, Abdi Wira Septama, and Akarawat Sinviratpong. "Synergistic activity of lawsone methyl ether in combination with some antibiotics and artocarpin against methicillin-resistant Staphylococcus aureus, Candida albicans, and Trychophyton rubrum." Chinese Herbal Medicines 11, no. 3 (July 2019): 321–25. http://dx.doi.org/10.1016/j.chmed.2019.06.001.

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Lin, Qin Hua, Jin Bin Yuan, Zhi Lin Ma, Jian Liang, Xiao Xiao Zhai, Ikhlas A. Khan, Yuan Qing Ding, and Gang Ren. "Isoprenylated Flavonoids from Roots of Artocarpus styracifolius." Natural Product Communications 11, no. 12 (December 2016): 1934578X1601101. http://dx.doi.org/10.1177/1934578x1601101217.

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Seven isoprenylated flavonoids were isolated from Artocarpus styracifolius, including one new triisoprenylated flavone, styracifolin D (1), and six known ones, artocarpone B (2), kuwanon C (3), 6-C-prenyl luteolin (4), albanin A (5), 2,4,2′,4′-tetrahydroxy-3′-(3-methyl-2-butenyl)-chalcone (6), and 3′-[γ-hydroxymethyl-( E)-γ-methylallyl]-2,4,2′,4′-tetrahydroxychalcone 11′- O-coumarate (7). The structures of these compounds were determined by analysis of their spectroscopic and mass spectrometric data. Of them, 3 and 5 exhibited inhibitory effects on cathepsin K with IC50 values of 114.6 and 7.4 μM, respectively.

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