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Journal articles on the topic 'Aryl derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Bonnier, Catherine, David S. Josey, and Timothy P. Bender. "Aryl-Substituted Boron Subphthalocyanines and their Application in Organic Photovoltaics." Australian Journal of Chemistry 68, no. 11 (2015): 1750. http://dx.doi.org/10.1071/ch15381.

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A family of five axial aryl-substituted boron subphthalocyanine (BsubPc) derivatives bearing a hydrido, methyl, methoxy, phenyl, or fluoro substituent at the para position of the aryl were synthesised from Br-BsubPc and the corresponding aryl Grignard reagent in moderate yields. The physicochemical characterisation of these derivatives gave similar absorption, photoluminescence, and cyclic voltammetry profiles and photoluminescence quantum yields, indicating that the nature of the substituent at the para position does not influence the basic photophysical properties of this generic class of Bs

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2

Dey, Supriya, and Narayanaswamy Jayaraman. "Branching out at C-2 of septanosides. Synthesis of 2-deoxy-2-C-alkyl/aryl septanosides from a bromo-oxepine." Beilstein Journal of Organic Chemistry 8 (April 10, 2012): 522–27. http://dx.doi.org/10.3762/bjoc.8.59.

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This paper deals with the synthesis of 2-deoxy-2-C-alkyl/aryl septanosides. A range of such septanoside derivatives was synthesized by using a common bromo-oxepine intermediate, involving C–C bond forming organometallic reactions. Unsaturated, seven-membered septanoside vinyl bromides or bromo-oxepines, obtained through a ring expansion methodology of the cyclopropane derivatives of oxyglycals, displayed a good reactivity towards several acceptor moieties in C–C bond forming Heck, Suzuki and Sonogashira coupling reactions, thus affording 2-deoxy-2-C-alkyl/aryl septanosides. Whereas Heck and So

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3

Szalóki Vargáné, Dóra, László Tóth, Balázs Buglyó, et al. "[1,5]-Hydride Shift-Cyclization versus C(sp2)-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines." Molecules 25, no. 6 (2020): 1265. http://dx.doi.org/10.3390/molecules25061265.

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Domino cyclization reactions of N-aryl-1,4- and 1,5-benzoxazepine derivatives involving [1,5]-hydride shift or C(sp2)-H functionalization were investigated. Neuroprotective and acetylcholinesterase activities of the products were studied. Domino Knoevenagel-[1,5]-hydride shift-cyclization reaction of N-aryl-1,4-benzoxazepine derivatives with 1,3-dicarbonyl reagents having active methylene group afforded the 1,2,8,9-tetrahydro-7bH-quinolino [1,2-d][1,4]benzoxazepine scaffold with different substitution pattern. The C(sp3)-H activation step of the tertiary amine moiety occurred with complete reg

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4

Xie, Yang, Zhou Xu, Pei Hu, et al. "Synthesis of the Isodityrosine Moiety of Seongsanamide A–D and Its Derivatives." Marine Drugs 21, no. 7 (2023): 373. http://dx.doi.org/10.3390/md21070373.

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The concise and highly convergent synthesis of the isodityrosine unit of seongsanamide A–D and its derivatives bearing a diaryl ether moiety is described. In this work, the synthetic strategy features palladium-catalyzed C(sp3)–H functionalization and a Cu/ligand-catalyzed coupling reaction. We report a practical protocol for the palladium-catalyzed mono-arylation of β-methyl C(sp3)–H of an alanine derivative bearing a 2-thiomethylaniline auxiliary. The reaction is compatible with a variety of functional groups, providing practical access to numerous β-aryl-α-amino acids; these acids can be co

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5

Julianto, T. S., F. J. Rachmawaty, H. A. Tamhid, and B. S. Putri. "THE POTENTIAL ANTIMALARIAL DRUG OF ARYL AMINO ALCOHOL DERIVATIVES FROM EUGENOL: SYNTHESIS, in-vitro AND in-silico ANALYSIS OF BIOACTIVITY." RASAYAN Journal of Chemistry 16, no. 03 (2023): 1425–34. http://dx.doi.org/10.31788/rjc.2023.1636940.

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Malaria is a significant cause of death in numerous countries, and the discovery of effective drugs is crucial. In this research, a new method was employed to synthesize a derivative of aryl amino alcohol using eugenol. Initially, an epoxide compound called 2-methoxy-4-(oxiran-2-ylmethyl) phenol was synthesized from eugenol by reacting it with peroxyacetic acid in dichloromethane. Subsequently, the epoxide compound was subjected to a reaction with various amine compounds, including aniline, naphthylamine, and diphenylamine for 10 minutes under 100 W microwave conditions, resulting in the produ

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6

Bi, Xian-Jun, Luke T. Higham, Janet L. Scott, and Christopher R. Strauss. "Reactions of 2,6-Dibenzylidenecyclohexanone and its Derivatives in High-Temperature Water." Australian Journal of Chemistry 59, no. 12 (2006): 883. http://dx.doi.org/10.1071/ch06381.

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The reactivity of derivatives of 2,6-dibenzylidenecyclohexanone was investigated in water at 220–250°C under microwave conditions, without added catalyst. Retro-Claisen–Schmidt processes predominated. Hydrolytic attack at the benzylic position afforded a 2-benzylidenecyclohexanone derivative and liberated an aryl aldehyde. Dienones substituted with electron-withdrawing or -donating groups on the aryl rings were more susceptible to hydrolysis than was the parent 2,6-dibenzylidenecyclohexanone.

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7

El-Essawy, Farag A., Wael A. El-Sayed, Sherif A. El-Kafrawy, Asmaa S. Morshedy, and Adel-H. Abdel-Rahman. "Anti-Hepatitis B Virus Activity of New 1,2,4-Triazol-2-yl- and 1,3,4-Oxadiazol-2-yl-2-pyridinone Derivatives." Zeitschrift für Naturforschung C 63, no. 9-10 (2008): 667–74. http://dx.doi.org/10.1515/znc-2008-9-1010.

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A number of 1,3,4-oxadiazole, 3 - 9, and 1,2,4-triazole derivatives, 13 - 15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from the substituted phenylthiosemicarbazide derivative 11 by treatment with sulfuric acid. The aryl hydrazone derivatives 10a - c were synthesized by reaction of the hydrazide 1 with the corresponding ketones. The thioalkyl derivatives 16a - e were prepared by akylation of the thiol derivatives 3 and 13 with different alkylating agents. The newly synthesized compounds were tested for their anti-HBV activity and some

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8

Soni, Love Kumar, Tamanna Narsinghani, and Rica Jain. "Synthesis and Antibacterial Screening of Some 1-Aroyl-3-aryl Thiourea Derivatives." ISRN Medicinal Chemistry 2014 (January 29, 2014): 1–6. http://dx.doi.org/10.1155/2014/393102.

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A series of 1-aroyl-3-aryl thioureas derivatives were synthesized and evaluated for antibacterial activity. The results indicated that the compounds possessed higher activity against gram-negative bacteria than gram-positive bacteria. Amongst all these compounds, C18 (89.4%) exhibited the greatest antibacterial activity against gram-negative bacteria while C5 (85.6%) displayed maximum antibacterial activity against gram-positive bacteria. Preliminary study of the structure-activity relationship revealed that an electronic factor on aryl rings had a great effect on the antibacterial activity of

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9

Liu, Feng, Haiyan Diao, and Zhangjie Shi. "Biaryl Construction Based on Nickel-Catalyzed C–O Bond Activation." Synlett 32, no. 15 (2021): 1494–512. http://dx.doi.org/10.1055/a-1349-3543.

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AbstractNickel-catalyzed carbon–oxygen bond activation is one of the most powerful strategies for the direct construction of various biaryl compounds. Under nickel catalysis, efficiently produced and naturally abundant arenol-based electrophiles can be activated and coupled with different aryl nucleophiles, including nucleophiles containing magnesium, zinc, boron, etc., to produce biaryl structural units. This Account summarizes recent progress on biaryl synthesis via nickel-catalyzed C–O bond activation.1 Introduction2 Coupling of Arenols and Arenol Derivatives with Aryl Magnesium Reagents3 C

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10

Patel, H. S., and H. D. Desai. "Synthesis of Some New Azetidinone Derivatives Containing Aryl Sulfonyloxy Group." E-Journal of Chemistry 1, no. 4 (2004): 194–98. http://dx.doi.org/10.1155/2004/258752.

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Some novel azetidinone derivatives containing aryl sulfonyloxy group have been prepared. The 4-sulfonyloxy aniline derivative (2) has been prepared by reaction of 4-nitro phenol (sodium salt) with N-acetyl sulfanilyl chloride (ASC) followed by hydrolysis by ethanolic HCl. This compound (2) undergoes facile condensation reaction with aromatic aldehydes to yield different Schiff’s bases (3a-h). Cyclocondensation of compounds (3a-h) with chloro acetyl chloride yields different 2-azetidinone derivatives (4a-h).

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11

Masri, Abdulkader, Ayaz Anwar, Naveed Ahmed Khan, et al. "Antibacterial Effects of Quinazolin-4(3H)-One Functionalized-Conjugated Silver Nanoparticles." Antibiotics 8, no. 4 (2019): 179. http://dx.doi.org/10.3390/antibiotics8040179.

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Infections due to multi-drug resistant bacteria are on the rise and there is an urgent need to develop new antibacterials. In this regard, a series of six functionally diverse new quinazolinone compounds were synthesized by a facile one-pot reaction of benzoic acid derivatives, trimethoxymethane and aniline derivatives. Three compounds of 3-aryl-8-methylquinazolin-4(3H)-one, and 3-aryl-6,7-dimethoxyquinazolin4(3H)-one were prepared and tested against multi-drug resistant bacteria. Furthermore, we determined whether conjugation with silver nanoparticles improved the antibacterial efficacy of th

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12

Mohamed, Mosaad, Samir Awad, and Naglaa Ahmed. "Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives." Acta Pharmaceutica 61, no. 2 (2011): 171–85. http://dx.doi.org/10.2478/v10007-011-0019-1.

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Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivativesA series of 6-aryl-5-cyano-2-thiouracil derivatives (1a-d) was synthesized by the reaction of ethyl cyanoacetate with thiourea and aldehydes. These products were used as intermediate compounds for the synthesis of a number of thiouracil derivatives (2a-dto10a-d). All compounds were screened for antibacterial and antifungal activities. Some of the prepared compounds, 6-(4-fluorophenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (2a), 4-oxo-2-thioxo-6-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropy

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13

Rafid Saad Dawood and Khetam Tareq Ahmed. "Synthesis and Characterization of New Pyrazoline and Isoxazoline Derivatives Based on Fluorene." Tikrit Journal of Pure Science 20, no. 2 (2023): 121–27. http://dx.doi.org/10.25130/tjps.v20i2.1169.

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The aim of the present work is a synthesis of new fluorene derivatives containing heterocyclic moieties. These compounds were synthesized in four groups, each group containing five compounds. The first group was made up of 2-(3-aryl-2-propenoyl) fluorene derivatives (1a-e) synthesized from the reaction of 2-acetyl fluorene with appropriate aromatic aldehyde in the presence of sodium hydroxide. The other three groups involved compounds produced from the reaction of (1a-e) with hydrazine hydrate (99%) in presence of acetic acid (96%) to give 1-acetyl-5-aryl-3-(fluoren-2-yl) pyrazoline derivative

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14

Ali El Hadi Mohamed, Rania, Nawal Al-Hoshani, Ali M. Drar, et al. "Combinatorial library of some aryl thioamides derivatives: Synthesis, chemical design, biological study and insecticidal evaluation against Spodoptera frugiperda." Bulletin of the Chemical Society of Ethiopia 39, no. 8 (2025): 1593–605. https://doi.org/10.4314/bcse.v39i8.11.

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Significant agricultural losses are caused by Spodoptera frugiperda, one of the most polyphagous migratory lepidopteran pest species. The exponential increase in resistance to existing chemical pesticides is another important factor driving the development of novel insecticidal active agents. To overcome this obstacle, it is essential to investigate new insecticidal substances with different modes of action. New aryl thioamide derivatives have been created by reacting aroyl chlorided, ammonium thiocyanate, and aromatic amines in dry acetone in a single pot with three components. Several spectr

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15

T. Male, Yusthinus, I. W. Sutapa, I. B. Kapelle, and M. Lopulalan. "QSAR MODELING AND DESIGN OF A NEW MODEL OF ANTIHIV DRUG 1-ARYL-TETRAHYDROISOQUINOLINE DERIVED USING THE PM3 SEMIEMPIRICAL METHOD." Rasayan Journal of Chemistry 15, no. 01 (2022): 359–68. http://dx.doi.org/10.31788/rjc.2022.1516479.

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Quantitative Structure-Activities Relationship Analysis (QSAR) on the 1-aryl-tetrahydroisoquinoline derivative as a candidate for the anti-HIV drug (Human Immunodeficiency Virus) has been done. The analysis using an electronic descriptor of atomic net charge, dipole moment, polarization, HOMO-LUMO energy, and log P was calculated using the PM3 semiempirical method. The best equation model is determined using multilinear regression analysis. The QSAR analysis show that the best QSAR equation model of 1-aryl-tetrahydroisoquinoline derivatives: pEC50= -23.019-10.867(qC3)-162.911(qC4)-107.057(qC6)

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16

Wei, Yuanyuan, Jie Wang, Yajun Wang, Xiaoqiang Yao, Caixia Yang, and Congde Huo. "Auto-oxidation promoted sp3 C–H arylation of glycine derivatives." Organic & Biomolecular Chemistry 16, no. 27 (2018): 4985–89. http://dx.doi.org/10.1039/c8ob01068d.

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An auto-oxidation promoted sp<sup>3</sup> C–H arylation reaction between N-aryl glycine derivatives and electron-rich arenes, leading to the formation of N-aryl α-aryl α-amino acid derivatives, is described. This atom-economical and environmentally benign reaction proceeds smoothly under mild reaction conditions and requires only Brønsted acid and oxygen (balloon). A plausible radical involved mechanism is proposed.

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17

Gineinah, Magdy. "6-, 7- AND 8-(5-ARY L-1-PHENYL-2-PYRAZOLIN-3-LY)IMIDAZO- AND PYRIMIDO[2,1-b]BENZOTHIAZOLES AS NOVEL ANTICONVULSANT AGENTS." Scientia Pharmaceutica 69, no. 1 (2001): 53–61. http://dx.doi.org/10.3797/scipharm.aut-01-06.

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Some new derivatives of 2-amino-5- and 6-(5-aryl-1-phenyl-2-pyrazolin-3-yl)benzothiazole were synthesized from the corresponding aminophenyl compounds by reaction with KSCN/Br2 to build up the benzothiazole ring. The aminophenyl derivatives of pyrazoline were prepared by cyclization with phenylhydrazine of the appropriate 1,3-diphenyl-2-propen-1-one derivatives obtained from arninoacetophenone and differently substituted aldehydes. However, the newly synthesized 2-aminobenzothiazole derivatives of pyrazoline were subjected to cyclization with ethyl brornopyruvate to afford the formation of 6-

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18

Al-Mansury, Sadiq, Suhad J. Hadi, Nabah H. Checkor, et al. "Evaluation of the analgesic activity of new derivatives of aryl propionic acid on gastric male mice." Sumer 1 8, CSS 1 (2023): 1–11. http://dx.doi.org/10.21931/rb/css/2023.08.01.17.

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This study focused on the recent synthesis of new compounds from aryl propionic acid derivatives compared to naproxen. The present study aimed to investigate the safety and efficiency of the new derivatives in improving analgesic effects and reducing adverse effects via modifying its chemical structure by adding new functional groups. The new compounds were characterized, and evaluate their pharmacodynamic effects. The analysis and characterization of new compounds were by 1HMNR and FT-IR spectrum. The investigation of the adverse effect after 5 days of remedy with 20 mg/kg daily administered

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19

El Kaïm, Laurent, Mansour Dolé Kerim, Pakoupati Boyode, and Julian Garrec. "Metal-Free Addition of Boronic Acids to Silylnitronates." Synlett 31, no. 09 (2020): 856–60. http://dx.doi.org/10.1055/s-0039-1690845.

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We report for the first time a metal-free addition of boronic acids to silylnitronates to afford oxime derivatives through aryl transfer on the carbon nitrogen double bond. A reaction mechanism has been proposed in relation with a DFT study on the key aryl transfer. This arylation process is effective for cycloalkenyl nitro derivatives leading to oximes that may be oxidatively converted into 3-arylisoxazole derivatives.

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20

A, Kumar Maddineni, Rao Chunduri V, and Raju Begari N. "Synthesis and Characterization of Novel Mono Carbonyl Curcumin Analogues of Pyrazole Derivatives." Der Pharma Chemica 13, no. 1 (2021): 6. https://doi.org/10.5281/zenodo.13644078.

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(E)-4-aryl-1-phenyl-1H-pyrazol-4-yl)but-3-en-2-one derivatives were (4a-d) synthesized by the condensation of 3-aryl-1-phenyl-1H-pyrazole-4- carbaldehyde derivatives (3a-d) with acetone in the presence of sodium hydroxide. Compounds (4a-d) on condensation with different aldehydes give mono carbonyl curcumin analogues (MACs) of pyrazole derivatives (6a-x) in good yield.

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21

Trilleras, Jorge, Jairo Quiroga, and Angelina Hormaza. "Synthesis of 3-Aroyl-4-heteroarylpyrrole Derivatives by the Van Leusen Method." Molbank 2022, no. 1 (2022): M1341. http://dx.doi.org/10.3390/m1341.

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The synthesis and structural diversification of N-heterocycles systems have attracted much attention because of their potential applications. Three 6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde 4 derivatives, in reaction with acetophenones 5, via conventional Claisen–Schmidt condensation reactions, generated the respective enones. The enones were used as electron-deficient olefins in a “formal” [2+3] cycloaddition reaction using p-tosylmethyl isocyanide—TosMIC 7. This protocol allows access to 3-(substituted aroyl)-4-heteroaryl pyrrole derivatives by the Van Leusen method.

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22

Saketi, Jagan Mohana Rao, S. N. Murthy Boddapati, Raghuram M., et al. "Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug." Applied Sciences 10, no. 11 (2020): 3792. http://dx.doi.org/10.3390/app10113792.

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A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches. The as-prepared indazole derivatives (3a–3j) and their N-methyl derivatives (5a–5j) are evaluated for in vitro anticancer activity against two cancer cell lines, HCT-116 and MDA-MB-231. The results reveal that the indazole derivatives tested display mild to moderate anticancer activities against the cell lines tested.

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23

Mistry, Rakesh N., and K. R. Desai. "Studies on Synthesis of Some Novel Heterocyclic Azlactone Derivatives and Imidazolinone Derivatives and their Antimicrobial Activity." E-Journal of Chemistry 2, no. 1 (2005): 42–51. http://dx.doi.org/10.1155/2005/542938.

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p- Methyl benzoic acid on reaction with phosphorus pentachloride gives p - methyl benzoyl chloride derivative which on condensation with glycine gives p - methyl benzoyl glycine derivative. Now, this p - methyl benzoyl glycine derivative on condensation with various substituted aldehydes gives corresponding substituted 4 - [aryl methylidine] - 2 - [p - methyl phenyl] - oxazole - 5 - one derivatives [1(a-j)]. Further, these derivatives [1(a-j)] on condensation with 4 , 4’ - diamino diphenyl sulphone gives corresponding substituted imidazolinone - dibenzsulphone derivatives [2(a-j)], on condensa

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24

Samiran, Kar, and Lahiri Saswati. "Photochemical intramolecular cyclization routes to heterocycles." Journal of Indian Chemical Society Vol. 76, Nov-Dec 1999 (1999): 607–10. https://doi.org/10.5281/zenodo.5862417.

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Department of Organic Chemistry, Indian Association for the Cultivation of Science, Calcutta-700 032, India <em>Manuscript received 27 August 1999</em> 1-Aryl-3-(2-azidoaryl)prop-2-en-1-ones have been prepared from <em>o</em>-nitro aromatic aldehydes. The 2-aroylindole derivatives are easily prepared from these derivatives in a tandem reaction sequence in moderate yields. Photolytic process is found to be much more facile than the thermal process in this transformation. Naphthofuran derivatives have been prepared by metalcatalyzed intramolecular photocyclizations of 1-aryl-3-(2-methoxy-1-napht

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25

Kapase, Valmik S. "Microwave Assisted Synthesis and QSAR Study of 1-Substituted-3-aryl-1H-pyrazole-4-carbaldehydes Derivatives." Asian Journal of Organic & Medicinal Chemistry 6, no. 2 (2021): 79–83. http://dx.doi.org/10.14233/ajomc.2021.ajomc-p315.

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Several 1-substituted-3-aryl-1H-pyrazole-4-carbaldehyde (3a-g) derivatives were synthesized by substituted acetophenone (1a-d), substituted hydrazine (2a-b) and DMF in POCl3 and reaction mixture was irradiated with microwave at 20% power to furnish 1-substituted-3-aryl-1H-pyrazole-4-carbaldehydes derivatives (3a-g).

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26

Mustafa Taha Abdull, Monther F. Mahdi, and Ayad k. Khan. "Molecular docking, Synthesis and Characterization of New Indomethacin and Mefenamic Acid Analogues as Potential Anti-inflammatory Agents." Al Mustansiriyah Journal of Pharmaceutical Sciences 23, no. 3 (2023): 336–44. http://dx.doi.org/10.32947/ajps.v23i3.1052.

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In this work the pharmacological study and synthesis of new thiadiazine bearing on triazole which obtained from hippuric acid , indomethacin and mefenamic acid that have carboxylic acid moiety, Drugs with carboxylic groups and thiocarbohydrazide interacted to produce the 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol (1a-c). and the starting products 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol) were treated with chloroacetyl chloride to produce final products (2a-c). To confirm the structure of the generated compounds, FT-IR, 1H-NMR, and mass spectroscopy were used to characterize all derivatives

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GAMAL, A. AHMED. "Studies on 3-Amino-I ,2,4-triazole." Journal of Indian Chemical Society Vol. 74, Aug 1997 (1997): 624–25. https://doi.org/10.5281/zenodo.5891468.

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Department of Chemistry , Faculty of Science, Zagazig University, Zagazig, Egypt <em>Manuscript received 16 October 1995, revised 18 June 1996, accepted 24 July 1996</em> 1,2,4-Triazolo[2,3-a]-1,3,5-triazine-4-aryl-4-thiones (3a,b) and 5-(aroylamino)-1,2,4-triazoles (5a,b) have been synthesised by the reaction of 3-amino-1,2,4-triazole (1) with aroyl isothiocyanates. Also, 1 when reacted with cinnamonitrile derivatives yields the trlazolopyrimldine derivatives (6, 7a,b and 8). Treatment of 8 with carbon disulphide and formaide gives 9 and 10 respectively. Some of the compounds possess antimicr

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Yu, Mingxin, Meijun Wang, Xiaohang Chen, Bingbing Hong, Xiaoyan Zhang, and Chienhong Cheng. "Synthesis of OLED Materials of Several Triarylamines by Palladium Catalysts and Their Light Emitting Property." Journal of Chemical Research 2005, no. 9 (2005): 558–60. http://dx.doi.org/10.3184/030823405774308961.

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Primary aryl amines reacted with aryl halides to give the secondary aryl amines by the catalysis of [Pd(dba)2/P(t-Bu)3] at 80 °C in toluene. Secondary aryl amines reacted with 1-bromo-pyrene and 9-bromo-phenanthrene and 2,7-dibromo-9H-fluorene to afford the OLED material of aminopyrene derivatives and aminophenanthrene derivatives and diamino-9H-fluorene type by the catalysis of [Pd(OAc)2/P(t-Bu)3] at 120 °C in o-xylene. The product structures were established by 1H NMR, 13C NMR, 13C(DEPT), HRMS spectra. Physical properties were examined by UV-vis, PL and DSC spectra.

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Khalaj, M., and M. Ghazanfarpour-Darjani. "Cross-coupling reaction of aryl diazonium salts with azodicarboxylate using FeCl2." RSC Advances 5, no. 98 (2015): 80698–701. http://dx.doi.org/10.1039/c5ra15875c.

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Waterloo, Andreas R., Anna-Chiara Sale, Dan Lehnherr, Frank Hampel, and Rik R. Tykwinski. "Aryl substitution of pentacenes." Beilstein Journal of Organic Chemistry 10 (July 28, 2014): 1692–705. http://dx.doi.org/10.3762/bjoc.10.178.

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A series of 11 new pentacene derivatives has been synthesized, with unsymmetrical substitution based on a trialkylsilylethynyl group at the 6-position and various aryl groups appended to the 13-position. The electronic and physical properties of the new pentacene chromophores have been analyzed by UV–vis spectroscopy (solution and thin films), thermoanalytical methods (DSC and TGA), cyclic voltammetry, as well as X-ray crystallography (for 8 derivatives). X-ray crystallography has been specifically used to study the influence of unsymmetrical substitution on the solid-state packing of the pent

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Pandhurnekar, Chandrashekhar P., Ekta M. Meshram, Himani N. Chopde, and Rameshkumar J. Batra. "Synthesis, Characterization, and Biological Activity of 4-(2-Hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols Derivatives." Organic Chemistry International 2013 (July 1, 2013): 1–10. http://dx.doi.org/10.1155/2013/582079.

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With the aim of synthesizing new heterocyclic compounds and exploring biological potency, new series of chalcones, that is, 3-(2-hydroxy-5-(aryl-diazenyl)phenyl)-1-(aryl)prop-2-en-1-one and their pyrimidine derivatives, that is, 4-(2-hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols were synthesized using different aromatic amines and salicylaldehyde as starting moieties. The structures of newly synthesized compounds were confirmed using different spectroscopic techniques such as IR, 1H-NMR, 13C-NMR, and mass spectral analysis, and elemental analysis. The newly synthesized pyrimidines d

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32

Li, Xinyao, Jun Pan, Song Song, and Ning Jiao. "Pd-catalyzed dehydrogenative annulation approach for the efficient synthesis of phenanthridinones." Chemical Science 7, no. 8 (2016): 5384–89. http://dx.doi.org/10.1039/c6sc01148a.

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Khalaj, Mehdi, Mahboubeh Taherkhani, Seyed Mousavi-Safavi, and Jafar Akbari. "Synthesis of Benzamide Derivatives by the Reaction of Arenes and Isocyanides through a C–H Bond Activation Strategy." Synlett 29, no. 01 (2017): 94–98. http://dx.doi.org/10.1055/s-0036-1588565.

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A carbon–carbon bond formation reaction between isocyanides and benzene derivatives is reported. In contrast to traditional cross-coupling reactions, which require aryl halides or pseudohalides, we use a palladium catalyst to generate the aryl–palladium through C–H bond activation of arenes. This method offers an attractive approach to a range of benzamides from readily accessible benzene derivatives.

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34

Doan Thi Yen, Oanh, Binh Vo Ngoc, and Anh Ngo Quoc. "SODIUM SULFIDE-PROMOTED REACTION OF 2-AMINOBENZAMIDE AND BENZYL ALCOHOLS WITH ELEMENTAL SULFUR: A NOVEL APPROACH WITH 2-ARYL-QUINAZOLIN-4(3H)." Journal of Science Natural Science 67, no. 3 (2022): 83–89. http://dx.doi.org/10.18173/2354-1059.2022-0044.

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A simple metal- and solvent-free method for the synthesis of 2-aryl- 4(3H)-quinazolinone derivatives from 2-aminobenzamide and benzyl alcohols in the presence of S8\DMSO as an oxidizing agent and promoted by Na2S.5H2O has been reported. Five 2-aryl-4(3H)-quinazolinone derivatives were synthesized with yields from 23% to 86%.

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35

Li, Jun, Constantin G. Daniliuc, Gerald Kehr, and Gerhard Erker. "A convenient route to internally phosphane-stabilized aryltriborane(7) compounds." Chemical Communications 54, no. 89 (2018): 12606–9. http://dx.doi.org/10.1039/c8cc06728g.

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36

Vora, J. J., S. B. Vasava, K. C. Parmar, S. K. Chauhan, and S. S. Sharma. "Synthesis, Spectral and Microbial Studies of Some Novel Schiff Base Derivatives of 4-Methylpyridin-2-amine." E-Journal of Chemistry 6, no. 4 (2009): 1205–10. http://dx.doi.org/10.1155/2009/247209.

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Schiff base derivatives ofN-{(1E)-[3-(mono or di-substituted aryl)-1-phenyl-1H-pyrazol-4-yl]methylene{-4-methylpyridin-2-amine were synthesized by the acid catalyzed condensation of 3-(mono- or di- substituted aryl)-1-phenyl-1H-pyrazole-4-carbaldehyde derivatives with 4-methylpyridin-2-amine. Schiff base derivatives were characterized by FT-IR,1H-NMR, Mass spectral analysis and elemental analysis. All the synthesized compounds have been screened for their antimicrobial activities by using broth dilution method.

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37

Shi, Qiu-Zhong, Yong-Nan Cao, Shi-Bing Ma, Guo-Xi Wang, Guang-Fan Han, and Zheng Xing. "Synthesis of Novel Ethyl 1-aryl-3-methyl-8-oxo-1,8-dihydropyrano[2′,3′:4,5] Pyrimido[6,1-b]Quinazoline-2-carboxylate Derivatives." Journal of Chemical Research 40, no. 12 (2016): 767–71. http://dx.doi.org/10.3184/174751916x14798109099372.

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In this paper, a new series of ethyl 1-aryl-3-methyl-8-oxo-1,8-dihydropyrano[2′,3′:4,5]pyrimido[6,1-b]quinazoline-2-carboxylate derivatives was synthesised by the cyclisation of methyl anthranilate with ethyl 5-cyano-6-[(ethoxymethylene)amino]-2-methyl-4-aryl-4H-pyran-3-carboxylate derivatives, which were obtained from reaction of triethyl orthoformate with 6-amino-5-cyano-2-methyl-4-aryl-4H- pyran-3-carboxylate derivatives. The title compounds possessed good fluorescence properties. In addition, ethyl 5-cyano-6-[(ethoxymethylene) amino]-2-methyl-4-(p-tolyl)-4H-pyran-3-carboxylate and ethyl 3-

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38

Pradip, P. Deohate, and N. Berad B. "Synthesis, characterization and antimicrobial study of substituted bis-[1 ,3,4]-oxadiazole, bis-[1 ,3,4]-thiadiazole and bis-[1,2,4]-triazole derivatives." Journal of Indian Chemical Society Vol. 85, Nov 2008 (2008): 1153–58. https://doi.org/10.5281/zenodo.5820567.

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Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444 001, Maharashtra, India <em>E-mail</em> : pradip22209l@yahoo.co.in Postgraduate Department of Chemistry, Shri Shivaji Science College, Amravati-444 603, Maharashtra, India <em>Manuscript received 29 April 2008, accepted 16 July 2008</em> Series of compounds 1,4-bis-(2-aryl/alky1-amino-[1,3,4]-oxadiazol-5-yI)-benzenes, 1,4-bis-(2-aryl/alkyl-amino[ 1,3,4]-thiadiazol-5-yl)-benzenes and 1,4-bis-(3-mercapto-4-aryl/alkyl-[1,2,4]-triazol-5-yl)-benzenes have been synthesized by the oxidative cyclization of di

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39

Miller, Eric M., Cody J. Brazel, Krystina A. Brillos-Monia, et al. "Reduction Potential Predictions for Some 3-Aryl-Quinoxaline-2-Carbonitrile 1,4-Di-N-Oxide Derivatives with Known Anti-Tumor Properties." Computation 7, no. 1 (2019): 6. http://dx.doi.org/10.3390/computation7010006.

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The ability for DFT: B3LYP calculations using the 6-31g and lanl2dz basis sets to predict the electrochemical properties of twenty (20) 3-aryl-quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives with varying degrees of cytotoxic activity in dimethylformamide (DMF) was investigated. There was a strong correlation for the first reduction and moderate-to-low correlation of the second reduction of the diazine ring between the computational and the experimental data, with the exception of the derivative containing the nitro functionality. The four (4) nitro group derivatives are clear outliers in

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40

Koch, Vanessa, and Stefan Bräse. "Pd-mediated cross-coupling of C-17 lithiated androst-16-en-3-ol – access to functionalized arylated steroid derivatives." Organic & Biomolecular Chemistry 15, no. 1 (2017): 92–95. http://dx.doi.org/10.1039/c6ob02496c.

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Herein, we report on Pd-mediated cross-coupling of vinyllithium steroids and aryl bromides to introduce various substituted aryls at C-17 of steroidal frameworks based on the structure of epi-androsterone.

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41

Reissig, Hans-Ulrich, and André Niermann. "7-Siloxy-Substituted Hexahydronaphthalene Derivatives: Samarium Diiodide Promoted Synthesis and Typical Reactions." Synthesis 52, no. 18 (2020): 2721–30. http://dx.doi.org/10.1055/s-0040-1707889.

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The samarium diiodide promoted reductive cyclization of a series of γ-aryl ketones with acetoxy, alkoxy, and siloxy groups in ortho-, meta-, and para-positions was investigated. Only precursors with p-acetoxy, p-tert-butoxy, or p-siloxy substituents furnished decent yields of the desired 7-oxy-1,2,3,4,6,8a-hexahydronaphthalene derivatives. The products were formed without contamination with the regioisomeric bicyclic products containing conjugated double bonds. Typical reactions exploiting the silyl enol ether moiety of the 7-(tert-butyldimethylsiloxy)-1,2,3,4,6,8a-hexahydronaphthalene deriv

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42

Kojima, Tatsuo, Shuichi Hiraoka, and Kazuho Ogata. "Selective Preparation of C 2v -Symmetric Hexaphenylbenzene Derivatives through Sequential Suzuki Coupling." Synlett 29, no. 12 (2018): 1597–600. http://dx.doi.org/10.1055/s-0037-1610024.

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We have developed effective reaction conditions for the Suzuki cross-coupling of chlorinated hexaphenylbenzene derivatives. A chloro group on a hexaphenylbenzene framework exhibits a low reactivity to Suzuki cross-coupling, and only nickel catalysts bearing alkyl-substituted phosphine ligands achieved the coupling. With this as a key step, we succeeded in the selective preparation of a C 2v -symmetric hexaphenylbenzene derivative containing two kinds of aryl group.

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43

Majumdar, Krishna C., Pradip Debnath, and Pradip K. Maji. "Radical-mediated cyclization reaction — Regioselective synthesis of pyrimidine- and coumarin-annulated [6,6]-fused oxygen heterocycles." Canadian Journal of Chemistry 86, no. 8 (2008): 846–54. http://dx.doi.org/10.1139/v08-087.

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The n-Bu3SnH-AIBN mediated aryl radical cyclization of various 8-[(2-bromophenoxy)methyl]-1,3-dimethyl-2,3,4,6-tetrahydro-1H-pyrano[3,2-d]pyrimidine-2,4-diones and 1-[(2-bromophenoxy)methyl]-3,5-dihydropyrano[2,3-c]coumarins was investigated with the formation of [6,6]-fused oxygen heterocycles as a single regioisomer.Key words: n-Bu3SnH-AIBN, aryl radical cyclization, 6-endo-trig, oxygen heterocycles, coumarin derivatives, pyrimidine derivatives.

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44

Nonn, Melinda, Loránd Kiss, Mikko M. Hänninen та Ferenc Fülöp. "An insight into the synthesis of novel aryl-substituted alicyclic β-amino acid derivatives through substrate-directed palladium-catalysed regio- and stereoselective cross-coupling". RSC Advances 5, № 18 (2015): 13628–34. http://dx.doi.org/10.1039/c4ra16196c.

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Novel aryl-substituted alicyclic β-amino acid derivatives were synthesized through substrate-determined palladium-catalysed cross-coupling of aryl iodides with five- or six-membered cycloalkene β-amino esters.

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45

Johnson, Stuart, Ervin Kovács, and Michael F. Greaney. "Arylation and alkenylation of activated alkyl halides using sulfonamides." Chemical Communications 56, no. 21 (2020): 3222–24. http://dx.doi.org/10.1039/d0cc00220h.

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46

Ogorodnik, A. G., V. A. Yanchenko, L. S. Bobkova, N. M. Seredinska та A. M. Demchenko. "Synthesis and anаlgеsic activity 5-methyl-3-aryl[1,2,4]triazolo[4,3-a]pyrimidin-7-oles derivatives". Farmatsevtychnyi zhurnal, № 2 (14 серпня 2018): 55–61. http://dx.doi.org/10.32352/0367-3057.2.17.07.

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Pain is a signal of inflammation and disruption of the body. It is the most important protective and adaptive mechanism that ensuring the safety of the individual. A strong and prolonged effect of "pain" irritant arising in injuries or after surgical manipulation transforms the protective reaction of the body to harmful factor that is the cause of secondary violations physiological processes. The aim of this work was the synthesis of substances in a series of 5-methyl-3-aryl [1,2,4] triazolo [4,3-a] pyrimidine-7-ol and study the analgesic effect of the synthesized compounds. The ob

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47

Shaw, Mukta, Yogesh Kumar, Rima Thakur, and Amit Kumar. "Electron-deficient pyridinium salts/thiourea cooperative catalyzed O-glycosylation via activation of O-glycosyl trichloroacetimidate donors." Beilstein Journal of Organic Chemistry 13 (November 9, 2017): 2385–95. http://dx.doi.org/10.3762/bjoc.13.236.

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The glycosylation of O-glycosyl trichloroacetimidate donors using a synergistic catalytic system of electron-deficient pyridinium salts/aryl thiourea derivatives at room temperature is demonstrated. The acidity of the adduct formed by the 1,2-addition of alcohol to the electron-deficient pyridinium salt is increased in the presence of an aryl thiourea derivative as an hydrogen-bonding cocatalyst. This transformation occurs under mild reaction conditions with a wide range of O-glycosyl trichloroacetimidate donors and glycosyl acceptors to afford the corresponding O-glycosides in moderate to goo

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48

Fegade, Bharti, and Shailaja Jadhav. "Design, Synthesis and Molecular Docking Study of N-Heterocyclic Chalcone Derivatives as an Anti-cancer Agents." International Journal of Pharmaceutical Sciences and Drug Research 14, no. 01 (2022): 78–84. http://dx.doi.org/10.25004/ijpsdr.2022.140111.

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The Claisen-Schmidt condensation of 4-(aryl)-aminobenzaldehyde and 2-hydroxyacetophenone resulted in a new series of heterocyclic chalcone (4a-4g) derivatives. Nucleophilic aromatic substitution (SNAr) of 4-fluorobenzaldehyde with heterocycle amines by ultrasonication in the presence of a base and polar aprotic solvent yielde 4-(aryl)-aminobenzaldehydes. Spectral investigations were used to establish the structures of synthesized compounds. The in vitro anti-cancer activity of the synthesized derivative was evaluated against MCF-7 (breast cancer) cells by SRB assay. Compounds 4c, 4b, and 4c ha

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49

Robinson, Henry, Joe Stillibrand, Klemensas Simelis, Simon J. F. Macdonald та Andrew Nortcliffe. "Iridium-catalysed C–H borylation of β-aryl-aminopropionic acids". Organic & Biomolecular Chemistry 18, № 34 (2020): 6696–701. http://dx.doi.org/10.1039/d0ob01495h.

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Iridium-catalysed C–H borylation of β-aryl-aminopropionic acid derivatives gives 3,5-functionalised protected β-aryl-aminopropionic acid boronates. One-pot borylation–functionalisation provides diverse building blocks for medicinal chemistry.

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50

Wang, Dongyin, Wei Liu, Fei Yi, Yongli Zhao, and Junmin Chen. "Palladium-catalyzed direct C–H arylation of 3-aryl-2H-benzo[1,2,4]thiadiazine 1,1-dioxides: an efficient strategy to the synthesis of benzothiadiazine-1,1-dioxide derivatives." Organic & Biomolecular Chemistry 14, no. 6 (2016): 1921–24. http://dx.doi.org/10.1039/c5ob02196k.

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An efficient strategy to the synthesis of 3-aryl-2H-benzo[1,2,4]thiadiazine 1,1-dioxide derivatives via palladium-catalyzed direct arylation of benzothiadiazine-1,1-dioxides with various aryl iodides is described.

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