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Dissertations / Theses on the topic 'Arylation'

Author: Grafiati
Published: 4 June 2021
Last updated: 19 April 2025

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1

Zhang, Chi Ph D. Massachusetts Institute of Technology Department of Chemistry. "Cysteine arylation." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/112448.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Proteins are the chemical and biological foundation of life. The longstanding goals of chemical biology are to understand the structure and function of proteins and to use these biomolecules for applications in chemistry, biology, medicine, and material science. To achieve such goals, highly efficient, selective, and robust chemical reactions are desired to modify proteins. For decades, cysteine-based reactions with maleimides
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2

Corrie, Thomas James Alexander. "Intramolecular direct arylation." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28820.

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The research conducted for this thesis has led to the development of an intramolecular gold-catalysed direct arylation protocol whereby tethered arenes and aryltrimethylsilanes are coupled (Scheme 1). In Chapter 1, the key synthetic and mechanistic studies that have ultimately led to the conception of this project are introduced. In Chapter 2, the substrate scope of intramolecular direct arylation is assessed. The reaction tolerates a wide range of substrates with tether lengths between one and five units (containing C, N and O) generating 5- to 9- membered rings. Substrates that lead to 5-mem
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3

Turner, Gemma L. "Direct arylation of thiazoles." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3188.

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An introduction to the thiazole ring system is presented together with a detailed, but non-exhaustive review of the rapidly emerging area of palladium-mediated directed arylation. The direct arylation of thiazole is also discussed together with our attempts to improve the established methods. A high-yielding, mild protocol has been developed for the functionalisation of the most electron-rich carbon-hydrogen bonds in a number of heterocyclic ring systems, this represents the first example of a C-H activation reaction being accomplished in aqueous media and allows access to a diverse range of f
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4

Evans, Ethan Daniel. "Long peptides for cysteine arylation." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/118258.

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Thesis: Ph. D. in Biological Chemistry, Massachusetts Institute of Technology, Department of Chemistry, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Biological reactivity is typically carried out by large enzymes. There are few examples of reactive, amino-acid-based polymers shorter than 100 residues in length. Of those that do exist, the majority are very short tags (<15 amino acids). Here, we attempted to first discover peptides roughly 30 amino acids in length that promote a nucleophilic aromatic substitution reaction and then understand the feat
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5

Fournier, Anne. "Intramolecular arylation of lithiated carbamates." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/intramolecular-arylation-of-lithiated-carbamates(165caa71-c229-4db3-a2e3-a77b097e5ef9).html.

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This thesis describes research carried out on the synthesis of tertiary alcohols or derivatives by N to C aryl/vinyl migration in lithiated carbamates. Section II.1 describes the first enantioselective synthesis of the antihistamine agent clemastine, as its (S,S)-stereoisomer as an illustration of the methodology. It has been achieved by ether formation between a proline-derived chloroethylpyrrolidine and an enantiomerically enriched tertiary alcohol. The tertiary alcohol was formed from the carbamate derivative of alpha-methyl-p-chlorobenzyl alcohol by invertive aryl migration on lithiation.
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6

Sävmarker, Jonas. "Palladium-Catalyzed Carbonylation and Arylation Reactions." Doctoral thesis, Uppsala universitet, Avdelningen för organisk farmaceutisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167720.

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Palladium-catalyzed reactions have found widespread use in contemporary organic chemistry due to their impressive range of functional group tolerance and high chemo- and regioselectivity. The pioneering contributions to the development of the Pd-catalyzed C-C bond forming cross-coupling reaction were rewarded with the Nobel Prize in Chemistry in 2010. Today, this is a rapidly growing field, and the development of novel methods, as well as the theoretical understanding of the various processes involved are of immense importance for continued progress in this field. The aim of the work presented
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7

Leblanc, Mélissa. "Synthèse d'allocolchicinoides via une arylation directe." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27264.

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Le motif biaryle tricyclique est un motif important en chimie médicinale et est présent dans une grande variété de produits naturels. Les chimistes ont développé au cours des années différentes méthodologies pour les synthétiser. La majorité des réactions impliquent l'utilisation d'un aryle fonctionnalisé par un organometallique et réagissant avec un halogénure d'aryle. Récemment, notre laboratoire rapportait une nouvelle procédure permettant de synthétiser des biaryles tricycliques d'une façon efficace et rapide. Cette nouvelle méthodologie est une réaction d'arylation directe catalysée par l
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8

Douglas, Gayle Elizabeth. "Investigations into direct N-arylation reactions." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/23026/.

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This thesis details investigations and the optimisation of N-arylation reactions using preciousmetal- free conditions. It is an important motif in several pharmaceutical and agrochemical molecules. In 1965 Bock et al described the use of concentrated sulfuric acid and acetic acid as the solvent in a modified version of the Hofmann-Lӧffler-Freytag to carry out direct amination of aromatics via N-haloamines.1 The first section looks at the UV irradiation chemistry where we utilised N-halo species which under photolytic conditions form the aminium radicals. Several examples of tetrahydroquinolin
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9

Williamson, Alice Elizabeth. "Novel methods for catalytic asymmetric arylation." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610600.

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10

Niwa, Takashi. "Studies on Palladium-Catalyzed Benzylic Arylation." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/77959.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(工学)<br>甲第14583号<br>工博第3051号<br>新制||工||1454(附属図書館)<br>26935<br>UT51-2009-D295<br>京都大学大学院工学研究科材料化学専攻<br>(主査)教授 大嶌 幸一郎, 教授 檜山 爲次郎, 教授 松原 誠二郎<br>学位規則第4条第1項該当
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11

Blaskovits, Terence. "Une étude computationnelle de la polymérisation par (hétéro)arylation directe : [A Computational Study of Direct (Hetero)arylation Polymerization]." Master's thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/34540.

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En comparaison avec d’autres techniques de couplage-croisé adaptées à la synthèse de polymères conjugués, la polymérisation par (hétéro)arylation directe (PHAD) s’avère avantageuse d’une perspective industrielle et environnementale. En effet, elle permet d’éviter l’utilisation d’agents de transmétallation nécessaires aux méthodes classiques de polymérisation. La réaction de PHAD exploite l’activation de liens aromatiques carbone-hydrogène (C–H) pour une synthèse efficace de polymères conjugués avec une excellente économie d’atomes. La réaction d’(hétéro)arylation directe permet la formation d’
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12

Lafrance, Marc. "Development of new palladium-catalyzed arylation reactions." E-theses uOttawa (Restricted to University of Ottawa), 2008. https://login.proxy.bib.uottawa.ca/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:NR41635.

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13

Liu, Haiyang. "Arylation of fibres to achieve disperse dyeability." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436409.

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14

Holden, Catherine. "Transition metal-free arylation and heterocycle synthesis." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/transition-metalfree-arylation-and-heterocycle-synthesis(4ecff18c-6cf9-4dfe-a874-1d83601c94d3).html.

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Arenes are ubiquitous motifs in both naturally occurring and synthetic functional organic molecules. The investigation of metal-free methodology for the installation of these motifs is important for sustainable development and the discovery of new modes of reactivity. Chapter 1. The preparation of halogenated phenoxathin 10,10 dioxides was ascertained to proceed through fluoride-induced decomposition and subsequent recombination of two molecules of the o-trimethylsilyl(aryl) triflate aryne precursors. Chapter 2. A new mild and metal-free methodology for the transition metal-free preparation of
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15

Tetlow, Daniel John. "α-Arylation of lithiated N-allyl ureas". Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/alphaarylation-of-lithiated-nallyl-ureas(c901ad80-be95-4257-8b31-f5363e59d544).html.

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The synthesis of amines bearing an adjacent quaternary stereocentre is challenging. Work within our group has demonstrated that the intramolecular transfer of an aryl group within a lithiated benzylic urea is possible. Subsequent cleavage of this urea moiety allows the synthesis of chiral aryl amines bearing quaternary stereocentres. This thesis details investigations into the lithiation of allylic and vinylic ureas. A sequential transformation of allyl ureas into diarylallyl ureas has been developed, a reaction that can be carried out enantioselectively using chiral lithium amides. Deprotecti
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16

Aspin, Samuel. "Arylation migratoire C(sp3)-H d'énolates d'esters." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10298.

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La fonctionnalisation C(sp3)-H catalysée par des métaux de transitions, ouvre de nombreuses perspectives en synthèse organique, permettant des voies d'accès plus économes en atomes, et en étapes à des molécules à forte valeur ajoutée. Dans cette optique, une méthode efficace permettant l'arylation des liaisons C(sp3)-H en position α d'un groupement attracteur, plus communément appelée α -arylation a récemment fait l'objet d'une attention toute particulière de la part de la communauté scientifique. Le travail détaillé dans ce manuscrit décrit les dernières avancées de cette méthodologie, ainsi
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17

Caron, Laurence. "Direct arylation of aromatic rings using palladium catalysis." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28232.

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The first section illustrates the novel route to access the biphenyl motif. Starting from simple materials, nitroarenes and aryl halides, we are able to obtain different cross-coupled products in good to moderate yields using palladium as a catalyst. The optimization of the reaction conditions as well as the various biaryl motifs obtained are described.* The second section summarizes our efforts towards the development of universal reaction conditions that can be used for the arylation of a wide range of heterocycles. Although direct arylation products are available in the literature, no broad
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18

Smith, Charlotte Louise. "α-Arylation as an entry to cytisine variants". Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.658203.

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The body of research in this thesis investigates the use of the Gallagher 3rd generation synthesis to make cytisine (i) and core variants of cytisine (ii) and (iii). A crucial step in the synthesis is the reduction of the lactam carbonyl, which can either be attempted before or after cyclisation. It was found that attempts to reduce the lactam carbonyl after cyclisation (iv) were unsuccessful, whereas reduction before cyclisation (v) was not reproducible. Alternative methodology to allow for the synthesis of a wider range of variants using a-arylation was developed. It was shown that the condi
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19

Yagoubi, Myriam. "Synthesis of heterocycles via palladium-catalysed direct arylation." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:e1206b3a-b9e8-4371-a94c-da3bc04c116e.

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Chapter 1 is a brief review on some of the recents developments in palladium-catalysed C-H functionalisation chemistry. The synthesis and functionalisation of heterocycles using these methodologies was particularly emphasised. Chapter 2 presents our efforts to identify a new catalytic system to promote the intramolecular coupling of vinyl bromides with unfunctionalised aryl C-H bonds for the formation of benzofurans. Dihydrobenzofurans were obtained efficiently under mild conditions in the presence of Pd(OAc)₂, X-Phos and K₂CO₃ in DMA at 80 °C and a subsequent one-pot isomerisation under acidi
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20

Sollert, Carina. "New Arylation Strategies Based on Organomain Group Reactivity." Doctoral thesis, Uppsala universitet, Institutionen för kemi - BMC, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-328750.

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The work in this thesis describes the development of new heteroarylation methodology based on transition metal-catalysed C-H functionalisation and the properties of organomain group compounds. The underlying reaction mechanisms and reactivity patterns of the (hetero)arene substrates are also investigated. The selective C2-H arylation indoles, which are key pharmaceutically-relevant units, was achieved using N-pyrimidyl directing groups, RuII catalysis and arylboronic acids as the coupling reagents (paper I). The use of this set of conditions enabled a remarkable functional group tolerance, hig
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21

Tait, Michael Buchanan. "α-Arylation of lithiated allylic and vinylic ureas". Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/aarylation-of-lithiated-allylic-and-vinylic-ureas(9403f676-5c28-49db-9b00-dc41a8977d16).html.

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Chiral amines are widespread in naturally occurring and synthetic bioactive molecules. However, it remains challenging to synthesise these molecules in an enantiopure form. Investigations within our group have shown that treatment of vinylic ureas with organolithium reagents results in an umpolung addition of the organolithium, followed by N to C aryl migration of the lithiated intermediate. This thesis details investigations into developing an enantioselective version of this reaction through the use of the chiral ligands (−)-sparteine and the (+)-sparteine surrogate. The enantioenriched urea
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22

Salcedo-Serna, Maria-Angela. "Synthèse de 1,4-benzodiazépines-2,5-diones et benzoxazole-isoindolinones par séquences : réaction d'Ugi / cyclisations intramoléculaires : travaux préliminaires pour une nouvelle synthèse de la phytosphingosine." Paris 11, 2007. http://www.theses.fr/2007PA112190.

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Le projet de thèse s’est articulé en trois parties. Dans les deux premières parties, nous avons développé des synthèses rapides d’hétérocycles facilement variables et très fonctionnalisés, via des séquences de réaction d’Ugi/cyclisation intramoléculaire. Nous avons pu mettre au point deux séquences générales permettant d’obtenir, en peu d’étapes à partir de produits commerciaux ou facilement accessibles, des 1,4-benzodiazépine-2,5-diones et des benzoxazole-isoindolinones. Les 1,4-benzodiazépine-2,5-diones ont été obtenues grâce une séquence domino N-arylation/couplage croisée palladocatalysé.
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23

Gilligan, Ruth Elaine. "Copper-catalyzed C-H arylation : development of new methodology and its application to the total synthesis of staurosporinone." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607788.

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24

Whipp, Christopher J. "Part 1: The Direct Arylation of Azine N-Oxides with Aryl Triflates Part 2: The Site-Selective Direct Arylation of Substituted Indoles." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28792.

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Part 1: The Direct Arylation of Azine N -Oxides with Aryl Triflates. Two sets of conditions for the palladium-catalyzed direct arylation of azine N-oxides with aryl triflates have been developed. Using palladium(II) acetate, a trialkylphosphine ligand, a carbonate base and pivalic acid, both mono- and diarylated azine N-oxides could be synthesized in good to excellent yields.* The reaction regioselectivity was examined for 3-substituted pyridine N-oxides, with arylation at C2 being favoured. The methodology was applied to the efficient formal synthesis of a biologically active diaryl pyridin
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25

Jepson, David. "Copper- and nickel-catalysed N-arylation of cyanate salts." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590419.

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The transition metal-catalysed N-arylation of cyanate salts represents an atom-economical approach to the synthesis of aryl isocyanates and isocyanate derivatives, which are commonly produced using hazardous reagents such as phosgene or azides. This thesis describes the development of copper and nickel-catalysed methodologies for the cross-coupling of aryl halides to commercially available cyanate salts, where reactions performed in the presence of various nucleophiles provide access to a wide range of useful products through intermolecular or intramolecular trapping. Firstly, an effective cop
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26

Long, Philip. "Rhodium-phosphinite catalysts for the ortho-arylation of phenols." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529840.

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27

Simoneti, Marco. "Novel approaches for Ru-promoted C-H arylation methods." Thesis, Queen Mary, University of London, 2016. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24249.

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The development of new procedures for the production of biologically and industrially relevant compounds still remains a big challenge in chemistry. The biaryl motif is ubiquitous among a wide range of compounds of industrial importance. For example, the biaryl skeleton is found in molecular switches and motors, agrochemicals or medicines such as antifungal, anticancer, antibiotics, anti-inflammatory treatments. These properties make the biaryl functionality a highly desirable synthetic target, for both commercial and research purposes. In this context, C-H arylation has been acknowledged as a
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28

Gatland, Alice Elizabeth. "Palladium-catalysed enolate arylation in the synthesis of isoquinolines." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f106760d-2375-4d56-81b2-faa6ee96cabc.

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<strong>Chapter 1. Introduction</strong> Scientific background on the development of homogeneous palladium-catalysed cross coupling reactions, focusing on the &alpha;-arylation reaction of enolates and its application to the synthesis of heteroaromatic compounds. The classical syntheses of isoquinolines are discussed, followed by an account of modern methods for their synthesis, including the recent &alpha;-arylation-based methodology developed by the Donohoe group. <strong>Chapter 2. Results and Discussion</strong> 2.1 Studies towards the development of a palladium-catalysed, C–H activation-b
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29

Lindstedt, Erik. "Metal-Free O- and C-Arylation with Diaryliodonium Salts." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-140944.

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This thesis concerns the development of metal-free applications using diaryliodonium salts. The first project describes an arylation protocol of allylic and benzylic alcohols in aqueous media. The method proceeds under mild conditions and the ether products were obtained in moderate to good yields. The methodology was also expanded to include arylation of phenols, giving diaryl ethers in good to excellent yields. In the second project, an arylation method that included a wider range of aliphatic alcohols was developed. The scope of accessible alkyl aryl ethers was studied and included a compar
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30

Tlili, Anis. "Arylation de nucléophiles catalysés par des complexes de cuivre." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2011. http://www.theses.fr/2011ENCM0010.

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Au cours de cette thèse, plusieurs nouvelles méthodes d'arylation de nucléophile (oxygéné, azoté et carboné) ont été mises au point ainsi qu'une étude mécanistique. Dans le cadre du projet ANR, nous avons réalisé des travaux dans ce domaine dans le laboratoire du Dr Anny Jutand à L'ENS Paris. D'un point de vue général, nous pouvons donc dire que nos méthodes se situent bien en phase avec les critères de la réglementation européenne visant à diminuer l'impact des produits chimiques sur l'environnement (REACH) par la recherche de nouvelles voies de synthèse moins toxiques et moins polluantes. Tr
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31

Grolleau, Jérémie. "Synthèse de nouveaux semi-conducteurs organiques par arylation directe." Thesis, Angers, 2016. http://www.theses.fr/2016ANGE0029/document.

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Les recherches sur le photovoltaïque organique depuis une dizaine d’année ont permis une constante progression de l’efficacité des cellules solaires. Plusieurs groupes de recherche ont amorcé une réflexion sur les procédés de synthèse qui permettraient de limiter les déchets. Ainsi le couplage par arylation directe qui évite l’utilisation de dérivés organométalliques a émergé comme alternative au couplage organométallique classique. Une première partie est consacrée à l’étude méthodologique du couplage par arylation directe de la triphénylamine avec des dérivés du thiophène-2- carboxaldéhyde s
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32

Mas-Roselló, Josep. "C-arylation and alkenylation of α-amino acid derivatives". Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.738542.

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33

Skhiri, Aymen. "Réactivité des chlorures de benzènesulfonyle pour l'accès à des hétéroarènes et alcènes arylés via des réactions pallado-catalysées." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1S080.

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Au cours de cette thèse, nous nous sommes intéressés à la synthèse d’hétérocycles arylés via l’activation de liaisons sp2 C-H d’hétéroaromatiques et à la synthèse d’alcènes arylés halo-substitués catalysée par le palladium. Les produits obtenus sont considérés comme des briques moléculaires, intéressantes pour les biochimistes, ainsi que pour la préparation de matériaux. Le système catalytique Pd(MeCN)2Cl2/Li2CO3/dioxane permet l’accès direct à une grande variété de molécules arylées à partir d’hétéroarènes ou d’alcènes et de chlorures de benzènesulfonyle. Nous avons mis au point une méthode p
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34

Hillgren, J. M. ikael. "Synthesis of quarternary asymmetric centres using novel enolate arylation chemistry." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509834.

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35

Brandt, Jochen Robert. "Site-selective copper-catalyzed arylation of aniline and phenol derivatives." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609610.

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36

Maxwell, Justin Michael. "Carbon Dioxide-Mediated C–H Arylation of Biologically-Relevant Amines." University of Toledo / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1576249564349573.

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37

Duvall, Bridget Rebecca. "Efforts toward (+)-7-deoxypancratistatin featuring a palladium catalyzed allylic arylation." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/2336.

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Thesis (M.S.)--University of Maryland, College Park, 2005.<br>Thesis research directed by: Dept. of Chemistry and Biochemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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38

Mingat, Gaelle. "Tertiary thiols via stereospecific α-arylation of lithiated allylic thiocarbamates". Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/tertiary-thiols-via-stereospecific-alphaarylation-of-lithiated-allylic-thiocarbamates(91e495f6-9924-4e96-8c23-50e84ea205ac).html.

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This thesis describes the work carried out on the lithiation and rearrangement of N-aryl- and N-vinyl allylic thiocarbamates, with the aim of preparing a wide range of versatile tertiary thiols. The synthesis of the racemic allylic starting materials has been achieved through in situ [3,3]-sigmatropic rearrangement of O-allylthiocarbamates to their S-counterparts (II.A). The enantioselective version relies either on asymmetric metal catalysis (achiral substrates) or stereospecificity (enantiopure substrates) in the [3,3]-sigmatropic rearrangement. Lithiation followed by N to C aryl migration p
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39

Seidl, Thomas Ludwig. "The Preparation of Diaryliodonium Salts for Application in Arylation Chemistry." PDXScholar, 2018. https://pdxscholar.library.pdx.edu/open_access_etds/4238.

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Diaryliodonium salts offer potential as novel reagents for arylation chemistry. An overall goal and successful outcome of this work has been to further understanding of diaryliodonium salt chemistry by developing practical methods that enable chemists more convenient access to these reagents, for the purpose of reaction development. To this end a robust and convenient preparation method has been developed and resulted in novel commercially available diaryliodonium salts. The remainder of the work described, has focused on understanding the parameters important to diaryliodonium mediated arylat
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40

Lainer, Bruno. "A multicatalytic approach to enantio-, and diastereoselective arylation of alcohols." Electronic Thesis or Diss., Strasbourg, 2023. http://www.theses.fr/2023STRAF080.

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Les groupements alcooliques sont présents dans une grande diversité de produits chimiques fins précieux issus de la nature et de la synthèse, c'est pourquoi les méthodes permettant leur diversification structurelle sont recherchées. Cependant, la modification de la structure des alcools à certaines positions non réactives, même avec l'aide de la catalyse, reste un défi ou nécessite des procédures multi-étapes fastidieuses et souvent coûteuses. Récemment, une attention accrue a été accordée à la multicatalyse, qui combine plusieurs catalyseurs au sein d'un même système, ce qui permet de découvr
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41

Sagnes, Charlène. "Synthèse, marquage TEP et validation de nouveaux radiopharmaceutiques des récepteurs sérotoninergiques 5-HT6 et 5-HT7." Thesis, Lyon 1, 2009. http://www.theses.fr/2009LYO10272.

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La sérotonine ou 5-hydroxytryptamine (5-HT) est un neurotransmetteur impliqué dans un grand nombre de fonctions physiologiques (thermorégulation, mémoire, sommeil, humeur…). La pluralité des troubles engendrés par un dysfonctionnement sérotoninergique s’explique par le grand nombre de récepteurs associés (5-HT1 à 5-HT7, eux-mêmes divisés en sous-groupes). Parmi eux, les récepteurs 5-HT6 et 5-HT7 sont les derniers à avoir été identifiés. A ce jour bien que leurs rôles biologiques restent méconnus, ils sembleraient être impliqués dans certaines pathologies psychiatriques (dépression, anxiété, sc
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42

Bielawski, Marcin. "Diaryliodonium Salts : Development of Synthetic Methodologies and α-Arylation of Enolates". Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-54738.

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This thesis describes novel reaction protocols for the synthesis of diaryliodonium salts and also provides an insight to the mechanism of α-arylation of carbonyl compounds with diaryliodonium salts.  The first chapter gives a general introduction to the field of hypervalent iodine chemistry, mainly focusing on recent developments and applications of diaryliodonium salts. Chapter two describes the synthesis of electron-rich to electron-poor diaryliodonium triflates, in moderate to excellent yields from a range of arenes and iodoarenes. In chapter three, it is described that molecular iodine can
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43

Hao, Xinyu. "Amidomonophosphane-Rodium(I) Complex Catalyzed Asymmetric Arylation of N-Phosphinoyl aldimine." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/124041.

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Mo, Jun. "Palladium catalyzed heck arylation of electron-rich olefins by aryl halides." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433729.

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Toh, Qiao Yan. "Organocatalysis in total synthesis and C-H bond arylation of aldehydes." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648134.

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46

Morin, Pierre-Olivier. "Développement de la polymérisation par (hétéro)arylation directe pour l'électronique organique." Doctoral thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/27087.

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L’électronique organique suscite un intérêt grandissant en recherche grâce aux nouvelles possibilités qu’elle offre pour faciliter l’intégration de dispositifs électroniques dans nos vies. Grâce à elle, il est possible d’envisager des produits légers, flexibles et peu coûteux à produire. Les classes majeures de dispositifs étudiées sont les cellules photovoltaïques organiques (CPO) et les transistors organiques à effet de champ (TOEC). Dans les dernières années, une attention particulière a été portée sur les méthodes de polymérisation des matériaux organiques entrant dans la fabrication de ce
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Viana, Hugo Ricardo Matos. "Studies on the catalytic intramolecular arylation: application of continuous flow systems." Doctoral thesis, Universidade de Évora, 2015. http://hdl.handle.net/10174/18215.

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Currently, neurodegenerative diseases like Alzheimer’s (AD) and Parkinson’s disease (PD) represent an important worldwide health problem. Over the last number of years, there have been many advances in the field of metal catalysed reactions. The palladium-catalysed intramolecular nucleophilic addition of arylborons and aryl halides to ketones constitutes an important methodology for the synthesis of chiral cycloalkanols. Our main objective was the development of a new efficient protocol for accessing the 1-aminotetralin and 1-aminoindane skeletons (Chapters 3 and 4). A secondary goal was to ob
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Ovadia, Benjamin. "Nouvelles réactions radicalaires multicomposants : carbo-arylation, carbo-oximation, carbo-alcénylation d'oléfines." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0451/document.

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L’objectif de ces travaux de thèse a consisté en le développement de nouveaux accepteurs sulfonylés pour l’élaboration de processus multicomposants radicalaires originaux. De nouvelles réactions de carbo-arylation, carbo-oximation et carbo-alcénylation d’oléfines ont ainsi été mises au point. Nous avons, dans un premier temps, étudié la faisabilité de nouvelles réactions de carbo-hétéroarylation basées sur deux modes d’activation des hétérocycles. Cette méthodologie s’est toutefois révélée être un réel défi en raison de la non-complémentarité des polarités du système, entrainant la formation d
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Sahoo, M. K. "Visible light mediated photoredox catalytic dehydrogenation and C-H arylation reactions." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2018. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/4557.

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Grenier, François. "Synthèse de polymères d'isoindigo utilisant de nouvelles méthodes évolutives de polymérisation par (hétéro)arylation directe." Doctoral thesis, Université Laval, 2021. http://hdl.handle.net/20.500.11794/69362.

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Les matériaux polymères conjugués offrent une combinaison avantageuse de propriétés mécaniques, électroniques et de mise en œuvre permettant de produire des composantes minces, ultra-flexibles et peu coûteuses. Au fil des avancées techniques, ces matériaux émergents ont démontré qu'ils avaient le potentiel de révolutionner plusieurs technologies, notamment pour la production d'énergie solaire, dans les transistors à effet de champs et pour la fabrication de diodes électroluminescentes organiques. La composition entièrement organique de ces matériaux les rend modulables, car il est possible d'a
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