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Journal articles on the topic 'Arylcoumarin'

Author: Grafiati
Published: 7 June 2025
Last updated: 2 August 2025

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1

Jung, Jong-Wha, Nam-Jung Kim, Hwayoung Yun, and Young Han. "Recent Advances in Synthesis of 4-Arylcoumarins." Molecules 23, no. 10 (2018): 2417. http://dx.doi.org/10.3390/molecules23102417.

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4-Arylcoumarins (4-aryl-2H-1-benzopyran-2-one), also known as neoflavones, comprise a minor subclass of naturally occurring flavonoids. Because of their broad-spectrum biological activities, arylcoumarins have been attracting the attention of the organic and medicinal chemistry communities, and are considered as an important privileged scaffold. Since the development of Pechmann condensation, a classical acid-catalyzed condensation between phenol and β-keto-carboxylic acid, several versatile and efficient synthetic approaches for 4-arylcoumarins have been reported. This review summarizes recen
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2

Yuan, Jin-Wei, Liang-Ru Yang, Qiu-Yue Yin, Pu Mao, and Ling-Bo Qu. "KMnO4/AcOH-mediated C3-selective direct arylation of coumarins with arylboronic acids." RSC Advances 6, no. 42 (2016): 35936–44. http://dx.doi.org/10.1039/c6ra04787d.

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3

Taechowisan, Thongchai, Chunhua Lu, Yuemao Shen, and Saisamorn Lumyong. "4-arylcoumarin inhibits immediate-type allergy." Food and Agricultural Immunology 18, no. 3-4 (2007): 203–11. http://dx.doi.org/10.1080/09540100701788636.

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4

D'Agostino, Mario, Vincenzo De Feo, Francesco De Simone, and Cosimo Pizza. "A 4-arylcoumarin from Coutarea hexandra." Phytochemistry 28, no. 6 (1989): 1773–74. http://dx.doi.org/10.1016/s0031-9422(00)97847-6.

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5

Aquino, Rita, Mario D'Agostino, Francesco de Simone, and Cosimo Pizza. "4-Arylcoumarin glycosides from Coutarea hexandra." Phytochemistry 27, no. 6 (1988): 1827–30. http://dx.doi.org/10.1016/0031-9422(88)80453-9.

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6

Su, Zushang, Ping Wang, Wei Yuan, and Shiyou Li. "Flavonoids and 3-Arylcoumarin from Pterocarpus soyauxii." Planta Medica 79, no. 06 (2013): 487–91. http://dx.doi.org/10.1055/s-0032-1328297.

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7

Pashazadeh, Rahim, Siyavash Mirzaei, Saideh Rajai-Daryasarei, et al. "Palladium-Catalyzed Carbonylation of Coumarin C(sp2)–H Bonds: A New Entry to Arylcoumarin Ketones." Synthesis 51, no. 07 (2018): 1680–88. http://dx.doi.org/10.1055/s-0037-1610675.

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A facile and efficient palladium-catalyzed carbonylation of coumarins involving two C–C bond formations has been developed. The C–H bond oxidative functionalization proceeds through aroylation with insertion of carbon monoxide to give arylcoumarin ketones. The reaction conditions, employing ambient pressures of CO gas as C1 feedstock, dramatically improve the generality of the carbonylation of aryl halides.
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8

Bardasov, Ivan N., Anastasiya U. Alekseeva, Oleg V. Ershov, Marina D. Surazhskaya, Andrei V. Churakov, and Dmitry A. Grishanov. "New approach to synthesis of 4-arylcoumarin derivatives." Tetrahedron Letters 56, no. 44 (2015): 6145–48. http://dx.doi.org/10.1016/j.tetlet.2015.09.111.

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9

Selikhov, A. N., Y. B. Malysheva, A. V. Nyuchev, et al. "Synthesis of hydrophilic and lipophilic 4-arylcoumarin phosphates." Russian Chemical Bulletin 60, no. 10 (2011): 2003–9. http://dx.doi.org/10.1007/s11172-011-0304-7.

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10

Zhang, Qiang, Yu-hang Miao, Teng Liu, et al. "Natural source, bioactivity and synthesis of 3-Arylcoumarin derivatives." Journal of Enzyme Inhibition and Medicinal Chemistry 37, no. 1 (2022): 1023–42. http://dx.doi.org/10.1080/14756366.2022.2058499.

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11

Sun, Jie, Wei Xian Ding, Ke Yun Zhang, and Yong Zou. "Efficient synthesis and biological evaluation of 4-arylcoumarin derivatives." Chinese Chemical Letters 22, no. 6 (2011): 667–70. http://dx.doi.org/10.1016/j.cclet.2010.12.017.

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12

K, Gupta. "3D-QSAR Analysis and Molecular Docking Studies on 3-Arylcoumarin Derivatives as Potential α- Glucosidase Inhibitors". Medicinal Chemistry 10, № 6 (2020): 5. https://doi.org/10.5281/zenodo.10669459.

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α-glucosidase inhibitors (AGI) are the structural moieties that are found to be of utmost importance in the fields of pharmacy and which involves delaying the absorption of carbohydrates by blocking of alpha-glucosidase enzyme in the brush border of small intestine and plays an important role in constituting a promising therapeutic class against diabetic disease (Type II). In this study, the three-dimensional quantitative structure-activity relationship (3D-QSAR) and docking models were developed using Fujito-Ban analysis in VALSTAT software and Molegro Virtual Docker 6.0. The theoretica
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13

Zhao, Huiping, Bin Yan, Laura B. Peterson, and Brian S. J. Blagg. "3-Arylcoumarin Derivatives Manifest Anti-proliferative Activity through Hsp90 Inhibition." ACS Medicinal Chemistry Letters 3, no. 4 (2012): 327–31. http://dx.doi.org/10.1021/ml300018e.

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14

Welser, Katharina, Jakob Grilj, Eric Vauthey, Jonathan W. Aylott, and Weng C. Chan. "Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates." Chem. Commun., no. 6 (2009): 671–73. http://dx.doi.org/10.1039/b816637d.

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15

Bailly, Christian, Christine Bal, Pascale Barbier, et al. "Synthesis and Biological Evaluation of 4-Arylcoumarin Analogues of Combretastatins." Journal of Medicinal Chemistry 46, no. 25 (2003): 5437–44. http://dx.doi.org/10.1021/jm030903d.

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16

Bardasov, Ivan N., Anastasiya U. Alekseeva, Oleg V. Ershov, Marina D. Surazhskaya, Andrei V. Churakov, and Dmitry A. Grishanov. "ChemInform Abstract: New Approach to Synthesis of 4-Arylcoumarin Derivatives." ChemInform 47, no. 9 (2016): no. http://dx.doi.org/10.1002/chin.201609167.

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17

Rajendran, M., J. Johnson Inbaraj, R. Gandhidasan, and R. Murugesan. "Photogeneration of reactive oxygen species by 3-arylcoumarin and flavanocoumarin derivatives." Journal of Photochemistry and Photobiology A: Chemistry 182, no. 1 (2006): 67–74. http://dx.doi.org/10.1016/j.jphotochem.2006.01.016.

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18

Joychandra Singh, Sarangthem, Bilal Ahmad Mir, and Bhisma K. Patel. "A TBPB-Mediated C-3 Cycloalkylation and Formamidation of 4-Arylcoumarin." European Journal of Organic Chemistry 2018, no. 8 (2018): 1026–33. http://dx.doi.org/10.1002/ejoc.201701677.

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19

Ugurel, Erennur, Ozkan Danis, Ozal Mutlu, Basak Yuce-Dursun, Cihan Gunduz, and Dilek Turgut-Balik. "Inhibitory effects of arylcoumarin derivatives on Bacteroides fragilis d‑lactate dehydrogenase." International Journal of Biological Macromolecules 127 (April 2019): 197–203. http://dx.doi.org/10.1016/j.ijbiomac.2019.01.040.

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20

Alparslan, Mustafa Muhlis, and Özkan Danış. "In VitroInhibition of Human Placental GlutathioneS-Transferase by 3-Arylcoumarin Derivatives." Archiv der Pharmazie 348, no. 9 (2015): 635–42. http://dx.doi.org/10.1002/ardp.201500151.

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21

Combes, Sébastien, Pascale Barbier, Soazig Douillard, et al. "Synthesis and Biological Evaluation of 4-Arylcoumarin Analogues of Combretastatins. Part 2." Journal of Medicinal Chemistry 54, no. 9 (2011): 3153–62. http://dx.doi.org/10.1021/jm901826e.

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22

Gong, Ting, Dong-Xiao Wang, Yan Yang, Ping Liu, Ruo-Yun Chen, and De-Quan Yu. "A Novel 3-Arylcoumarin and Three New 2-Arylbenzofurans from Mucuna birdwoodiana." CHEMICAL & PHARMACEUTICAL BULLETIN 58, no. 2 (2010): 254–56. http://dx.doi.org/10.1248/cpb.58.254.

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23

Hu, Yuheng, Bing Wang, Jie Yang, Teng Liu, Jie Sun, and Xiaojing Wang. "Synthesis and biological evaluation of 3-arylcoumarin derivatives as potential anti-diabetic agents." Journal of Enzyme Inhibition and Medicinal Chemistry 34, no. 1 (2018): 15–30. http://dx.doi.org/10.1080/14756366.2018.1518958.

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24

Matos, Maria João, Fernanda Rodríguez-Enríquez, Santiago Vilar, et al. "Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives." Bioorganic & Medicinal Chemistry Letters 25, no. 3 (2015): 642–48. http://dx.doi.org/10.1016/j.bmcl.2014.12.001.

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25

Sashidhara, Koneni V., Ram K. Modukuri, Pooja Jadiya, et al. "Discovery of 3-Arylcoumarin-tetracyclic Tacrine Hybrids as Multifunctional Agents against Parkinson’s Disease." ACS Medicinal Chemistry Letters 5, no. 10 (2014): 1099–103. http://dx.doi.org/10.1021/ml500222g.

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26

Abdel-Kader, Maged S., Omer A. Basudan, Mehtab Parveen, and Masouda E. Amer. "A new 3-arylcoumarin from the roots of an Egyptian collection ofLotus polyphyllos." Natural Product Research 22, no. 5 (2008): 448–52. http://dx.doi.org/10.1080/14786410701591812.

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27

Mutai, Peggoty, Gilles Breuzard, Alessandra Pagano, Diane Allegro, Vincent Peyrot, and Kelly Chibale. "Synthesis and biological evaluation of 4 arylcoumarin analogues as tubulin-targeting antitumor agents." Bioorganic & Medicinal Chemistry 25, no. 5 (2017): 1652–65. http://dx.doi.org/10.1016/j.bmc.2017.01.035.

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28

Danis, Ozkan, Serap Demir, Cihan Gunduz, Mustafa Muhlis Alparslan, Selcuk Altun, and Basak Yuce-Dursun. "Synthesis of selected 3- and 4-arylcoumarin derivatives and evaluation as potent antioxidants." Research on Chemical Intermediates 42, no. 6 (2016): 6061–77. http://dx.doi.org/10.1007/s11164-016-2445-7.

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29

Khomenko, Tatyana M., Alexandra L. Zakharenko, Arina A. Chepanova, et al. "Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy." International Journal of Molecular Sciences 21, no. 1 (2019): 126. http://dx.doi.org/10.3390/ijms21010126.

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Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans, and a current and promising inhibition target for the development of new chemosensitizing agents due to its ability to remove DNA damage caused by topoisomerase 1 (Top1) poisons such as topotecan and irinotecan. Herein, we report our work on the synthesis and characterization of new Tdp1 inhibitors that combine the arylcoumarin (neoflavonoid) and monoterpenoid moieties. Our results showed that they are potent Tdp1 inhibitors with IC50 values in the submicromolar range. In vivo experiments with mice revealed tha
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30

Siti, Fadilah Juhan, MariamMohd Nor Siti, Kartinee Kassim Nur, Munirah Mohd Faudzi Siti, and Shukri Mat Ali Mohd. "One-Step Synthesis of New Derivatives of 4-Arylcoumarins and Neolignans." Chemistry Research Journal 3, no. 4 (2018): 85–97. https://doi.org/10.5281/zenodo.13833621.

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Coupling reaction of iodovanillin or vanillin with methyl cinnamate derivatives catalysed by palladium(II) acetate yield five new compounds including three neolignans and two 4-arylcoumarins along with two known lignans and two known neolignans. Structures of all synthesized lignans, neolignans and coumarins were elucidated on the basis of various spectroscopic data (1D-NMR, 2D-NMR, IR and MS), melting point and by comparison with reported data.
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31

Pu, Wen-Chen, Guan-Min Mu, Guo-Lin Zhang, and Chun Wang. "Copper-catalyzed decarboxylative intramolecular C–O coupling: synthesis of 2-arylbenzofuran from 3-arylcoumarin." RSC Adv. 4, no. 2 (2014): 903–6. http://dx.doi.org/10.1039/c3ra46414h.

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32

Tawata, Masato, Yoshiki Yoda, Kaoru Aida, et al. "Anti-Platelet Action of GU-7, A 3-Arylcoumarin Derivative, Purified from Glycyrrhizae Radix." Planta Medica 56, no. 03 (1990): 259–63. http://dx.doi.org/10.1055/s-2006-960951.

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33

de Souza Santos, Marcela, Maria Perpétua Freire de Morais Del Lama, Laila Aparecida Deliberto, Flávio da Silva Emery, Mônica Tallarico Pupo, and Rose Mary Zumstein Georgetto Naal. "In situ screening of 3-arylcoumarin derivatives reveals new inhibitors of mast cell degranulation." Archives of Pharmacal Research 36, no. 6 (2013): 731–38. http://dx.doi.org/10.1007/s12272-013-0084-8.

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34

Gong, Ting, Dong-Xiao Wang, Yan Yang, Ping Liu, Ruo-Yun Chen, and De-Quan Yu. "ChemInform Abstract: A Novel 3-Arylcoumarin and Three New 2-Arylbenzofurans from Mucuna birdwoodiana." ChemInform 41, no. 29 (2010): no. http://dx.doi.org/10.1002/chin.201029212.

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35

Juhan, Siti Fadilah, Siti Mariam Mohd Nor, Mohd Shukri Mat Ali, and Siti Zulaika Md Nor. "LARVICIDAL ACTIVITY OF THE SYNTHESISED LIGNANS, NEOLIGNANS, AND COUMARIN AGAINST Crocidolimia binotalis 2nd INSTAR LARVAE." Malaysian Journal of Science 42, no. 1 (2023): 7–16. http://dx.doi.org/10.22452/mjs.vol42no1.2.

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Five compounds comprising 8-O-4’-neolignan (7), two arylnaphthalene lignans (5, 8), aryldihydrobenzofuran neolignan (4), and lignan (6) were synthesised by enzymatic coupling reaction using horseradish peroxidase (HRP) between vanillin (1) with methyl ferulate (2) or methyl sinapate (3). All of these compounds, as well as previously synthesised palladium-catalysed coupling products of neolignan (9), 8-O-4'-neolignan (10), arylcoumarin (11), and lignan (12), were examined for larvicidal activity against Crocidolomia binotalis 2nd instar larvae. It revealed that seven out of nine synthesised com
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36

Li, YuFei, Yinbo Pan, Liying Wang, et al. "3-Arylcoumarin inhibits vascular calcification by inhibiting the generation of AGEs and anti-oxidative stress." Journal of Enzyme Inhibition and Medicinal Chemistry 37, no. 1 (2022): 2147–57. http://dx.doi.org/10.1080/14756366.2022.2109024.

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37

Billard, Christian, Faouzia Menasria, Claire Quiney, et al. "4-Arylcoumarin analogues of combretastatins stimulate apoptosis of leukemic cells from chronic lymphocytic leukemia patients." Experimental Hematology 36, no. 12 (2008): 1625–33. http://dx.doi.org/10.1016/j.exphem.2008.07.008.

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38

Okuyama, Toru, Masaki Baba, Ryoya Asano, et al. "Studies of the Egyptian Traditional Folk Medicines. III. A New Diprenylated 3-Arylcoumarin from Egyptian Licorice." HETEROCYCLES 51, no. 2 (1999): 387. http://dx.doi.org/10.3987/com-98-8414.

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39

Schio, Laurent, Fabienne Chatreaux, and Michel Klich. "Tosylates in palladium-catalysed coupling reactions. Application to the synthesis of arylcoumarin inhibitors of gyrase B." Tetrahedron Letters 41, no. 10 (2000): 1543–47. http://dx.doi.org/10.1016/s0040-4039(99)02351-5.

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40

Wu, Jie, Lisha Wang, Reza Fathi, and Zhen Yang. "Palladium-catalyzed cross-coupling reactions of 4-tosylcoumarin and arylboronic acids: synthesis of 4-arylcoumarin compounds." Tetrahedron Letters 43, no. 24 (2002): 4395–97. http://dx.doi.org/10.1016/s0040-4039(02)00718-9.

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41

Pu, Wen-Chen, Guan-Min Mu, Guo-Lin Zhang, and Chun Wang. "ChemInform Abstract: Copper-Catalyzed Decarboxylative Intramolecular C-O Coupling: Synthesis of 2-Arylbenzofuran from 3-Arylcoumarin." ChemInform 45, no. 29 (2014): no. http://dx.doi.org/10.1002/chin.201429128.

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42

Rappl, Catherine, Pascale Barbier, Véronique Bourgarel-Rey, et al. "Interaction of 4-Arylcoumarin Analogues of Combretastatins with Microtubule Network of HBL100 Cells and Binding to Tubulin†." Biochemistry 45, no. 30 (2006): 9210–18. http://dx.doi.org/10.1021/bi060476g.

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43

MUSA, MUSILIYU A., VEERA L. D. BADISA, LEKAN M. LATINWO, and ELIZABETH NTANTIE. "7,8-Dihydroxy-3-arylcoumarin Induces Cell Death Through S-Phase Arrest in MDA-MB-231 Breast Cancer Cells." Anticancer Research 38, no. 11 (2018): 6091–98. http://dx.doi.org/10.21873/anticanres.12959.

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44

Schio, Laurent, Fabienne Chatreaux, and Michel Klich. "ChemInform Abstract: Tosylates in Palladium-Catalyzed Coupling Reactions. Application to the Synthesis of Arylcoumarin Inhibitors of Gyrase B." ChemInform 31, no. 24 (2010): no. http://dx.doi.org/10.1002/chin.200024136.

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45

Wu, Jie, Lisha Wang, Reza Fathi, and Zhen Yang. "ChemInform Abstract: Palladium-Catalyzed Cross-Coupling Reactions of 4-Tosylcoumarin and Arylboronic Acids: Synthesis of 4-Arylcoumarin Compounds." ChemInform 33, no. 38 (2010): no. http://dx.doi.org/10.1002/chin.200238126.

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46

Moiseeva, E. V., N. R. Kuznetsova, E. V. Svirshchevskaya, et al. "Liposome formulations of combretastatin a4 and 4-arylcoumarin analog prodrugs: antitumor effect in the mouse model of breast cancer." Biomeditsinskaya Khimiya 58, no. 3 (2012): 326–38. http://dx.doi.org/10.18097/pbmc20125803326.

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The antimitotic agent combretastatin A4 (СА-4) has been suggested as an antivascular agent for anticancer therapy relatively recently. To reduce systemic toxicity by means of administration in liposome formulations, in this study new lipophilic prodrugs, oleic derivatives of СА-4 and its 4-arylcoumarin analog (СА4-Ole and ArC-Ole, respectively), have been synthesized: Liposomes of 100 nm mean diameter prepared on the basis of egg phosphatidylcholine and phosphatidylinositol from bakers yeast have been shown to include completely up to 10 mol. % of СА4-Ole, or 7 mol. % of ArC-Ole. Also, prodrug
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47

Matos, Maria João, Santiago Vilar, Verónica García-Morales, et al. "Insight into the Functional and Structural Properties of 3-Arylcoumarin as an Interesting Scaffold in Monoamine Oxidase B Inhibition." ChemMedChem 9, no. 7 (2014): 1488–500. http://dx.doi.org/10.1002/cmdc.201300533.

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48

Moiseeva, E. V., N. R. Kuznetsova, E. V. Svirshchevskaya, et al. "Liposome formulations of combretastatin A4 and its 4-arylcoumarin analogue prodrugs: The antitumor effect in the mouse model of breast cancer." Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 5, no. 3 (2011): 276–83. http://dx.doi.org/10.1134/s1990750811030073.

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49

Kawaai, Kazuki, Tomoaki Yamaguchi, Eiji Yamaguchi, et al. "Photoinduced Generation of Acyl Radicals from Simple Aldehydes, Access to 3-Acyl-4-arylcoumarin Derivatives, and Evaluation of Their Antiandrogenic Activities." Journal of Organic Chemistry 83, no. 4 (2018): 1988–96. http://dx.doi.org/10.1021/acs.joc.7b02933.

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50

Yakarsonmez, Sinem, Ozkan Danis, Ozal Mutlu, et al. "Discovery and evaluation of inhibitory activity and mechanism of arylcoumarin derivatives on Theileria annulata enolase by in vitro and molecular docking studies." Molecular Diversity 24, no. 4 (2019): 1149–64. http://dx.doi.org/10.1007/s11030-019-10018-9.

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