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Journal articles on the topic 'Arylidene compounds'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Shah, Shalini K., and Anju Goyal. "Synthesis and Biological Evaluation of Some Novel Arylidene Hydrazides Derivatives." Asian Pacific Journal of Health Sciences 9, no. 4 (2022): 203–9. http://dx.doi.org/10.21276/apjhs.2022.9.4s.39.

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There has been considerable interest in the development of novel compounds with anticonvulsant, antioxidant, antibacterial, and antifungal activities. The present study explores the antimicrobial activity of some new arylidene hydrazide derivatives and correlates the effect on the antimicrobial potency by varying the substituents on hydrazide part of the arylidine hydrazide. Hydrazones possessing an azomethine–NHN=CH- proton constitute an important class of compounds for new drug developments; therefore, a series of arylidene hydrazides were synthesized with various aromatic aldehydes/ketones.

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2

Kouzi, Olympia, Eleni Pontiki, and Dimitra Hadjipavlou-Litina. "2-Arylidene-1-indandiones as Pleiotropic Agents with Antioxidant and Inhibitory Enzymes Activities." Molecules 24, no. 23 (2019): 4411. http://dx.doi.org/10.3390/molecules24234411.

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Indandiones are a relatively new group of compounds presenting a wide range of biological activities. The synthesis of these compounds was performed via a Knoevenagel reaction between an aldehyde and 1,3-indandione and were obtained with a yield up to 54%. IR, 1H-Nucleic Magnetic Resonance (NMR), 13C-NMR, LC/MS ESI+ and elemental analysis were used for the confirmation of the structures of the novel derivatives. Lipophilicity values of compounds were calculated theoretically and experimentally by reversed chromatography method as values RM. The novel derivatives were studied through in vitro a

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3

Guarda, V. L. M., C. Bosso, S. L. Galdino, et al. "Mass spectrometry of some arylidene thioxobenzyl or thioxobiphenyloxoethyl thiazolidinone compounds." Spectroscopy 18, no. 4 (2004): 613–19. http://dx.doi.org/10.1155/2004/175870.

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This paper reports the results of a comparative study of the electron impact mass spectrometry data for a series of previously synthetized 5-arylidene-3-(4-chloro-benzyl)-4-thioxo-thiazolidin-2-one, and 5-arylidene-3-(2-biphenyl-4-yl-2-oxo-ethyl)-4-thioxo-thiazolidin-2-one derivatives. Theoretical calculations of molecular mechanics, MOPAC‒AM1, were used to explain the fragmentations observed.

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4

Husain, Asif, Mumtaz Alam, and Nadeem Siddiqui. "Synthesis, reactions and biological activity of 3-arylidene-5-(4-methylphenyl)-2(3H)-furanones?" Journal of the Serbian Chemical Society 74, no. 2 (2009): 103–15. http://dx.doi.org/10.2298/jsc0902103h.

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3-Arylidene-5-(4-methylphenyl)-2(3H)-furanones 2a-m were prepared from 3-(4-methyl-benzoyl)propanoic acid 1 and several aromatic aldehydes. Some of the selected furanones were reacted with ammonia gas and benzylamine to give corresponding 3-arylidene-1,3-dihydro-5-(4-methylphenyl)-2H-pyrrol- 2-ones 3a-h and 3-arylidene-1-benzyl-1,3-dihydro-5-(4-methylphenyl)-2H- -pyrrol-2-ones 4a-f, respectively, which were characterized on the basis of IR, 1H-NMR, mass spectral data and elemental analysis results. These compounds were tested for their anti-inflammatory and antibacterial activities. The compou

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5

Basavaiah, Deevi, and Daggula Mallikarjuna Reddy. "The Baylis–Hillman acetates in organic synthesis: Unprecedented sodium nitrite induced intramolecular Friedel–Crafts cyclization of secondary nitro compounds." RSC Adv. 4, no. 46 (2014): 23966–70. http://dx.doi.org/10.1039/c4ra03573a.

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Unprecedented sodium nitrite mediated intramolecular Friedel–Crafts cyclization of alkyl (E)-2-arylidene-4-nitroalkanoates and (E)-3-arylidene-5-nitroalkan-2-ones derived from Baylis–Hillman acetates has been described.

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6

N. R., Mohame, El-Saidi M. M. T., Abdel Aziz S . A., and Zayed M. F. "The Behaviour of Arylidene Barbituric Acid and Cyclohexadione Derivatives Towards Tris(dimethy1amino)phosphin." Scientia Pharmaceutica 70, no. 2 (2002): 147–63. http://dx.doi.org/10.3797/scipharm.aut-02-17.

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Tris(dimethy1amino)phosphine 1 reacted with phenylarylidene barbituric acids 4 to yield the triaminophosphonium dipolar ion adduct 7. 2-Arylidene-1,3- cyclohexanedione 5 and 2-Arylidene-5,5-dimethylcyclohaxane1-,3 -diones 6 reacted with phosphine 1 to produce the dioxyxanthenes 10 and 12, respectively. Structural assignments are based on analytical, chemical, and spectroscopic evidences. A mechanism is proposed to explain the formation of these compounds. The biological acitivity of the new synthesized compounds against Aphis Craccivora, a serious pest infecting many crops in Egypt, was studie

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7

Brito, Vanessa, Gilberto Alves, Paulo Almeida, and Samuel Silvestre. "Highlights on Steroidal Arylidene Derivatives as a Source of Pharmacologically Active Compounds: A Review." Molecules 26, no. 7 (2021): 2032. http://dx.doi.org/10.3390/molecules26072032.

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Steroids constitute a unique class of chemical compounds, playing an important role in physiopathological processes, and have high pharmacological interest. Additionally, steroids have been associated with a relatively low toxicity and high bioavailability. Nowadays, multiple steroidal derivatives are clinically available for the treatment of numerous diseases. Moreover, different structural modifications on their skeleton have been explored, aiming to develop compounds with new and improved pharmacological properties. Thus, steroidal arylidene derivatives emerged as a relevant example of thes

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8

Özdemir, Ahmet, Sevtem Gökbulut, Belgin Sever, Gülşen A. Çiftçi, and Mehlika D. Altıntop. "Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents." Anti-Cancer Agents in Medicinal Chemistry 18, no. 10 (2019): 1394–404. http://dx.doi.org/10.2174/1871520618666171206111923.

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Background: Arylidene indanones have attracted a great deal of interest due to their outstanding therapeutic applications. In particular, considerable research has pointed out the importance of arylidene indanones in the field of cancer research. Objective: The aim of the current work was to design and synthesize arylidene indanone-based anticancer agents. Method: New arylidene indanones were obtained via the Claisen-Schmidt condensation of 5-chloro-6-methoxy- 2,3-dihydro-1H-inden-1-one with p-substituted benzaldehyde derivatives. MTT assay was performed to evaluate their cytotoxic effects on

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9

Allahyani, Mamdouh, Mazen Almehmadi, Osama Abdulaziz, et al. "Synthesis and in vitro antimicrobial screening of some 5-methyl-2-substituted phenyl-3- (phenylsulfonyl)thiazolidin-4-ones." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 04 (2024): 499. https://doi.org/10.59467/ijhc.2024.34.499.

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The synthesis of some new thiazolidine-sulfonamide derivatives was achieved in two steps. In the first step, appropriate aryl aldehyde reacted with benzene sulfonamide to yield N-arylidene benzene sulfonamide derivatives (1a-h). In the second step, compounds (1a-h) reacted with thiolactic acid to give the 5-methyl-2-substituted phenyl-3-(phenylsulfonyl) thiazolidin-4-one derivatives (2a-h). The compounds 2a-h were screened for their in vitro antimicrobial activity by agar disc diffusion method. The results showed that compounds 2b, 2c, and 2d exhibited anti-microbial activity against the teste

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10

Dabholkar, Vijay, and Faisal Ansari. "Synthesis and characterization of selected fused isoxazole and pyrazole derivatives and their antimicrobial activity." Journal of the Serbian Chemical Society 74, no. 11 (2009): 1219–28. http://dx.doi.org/10.2298/jsc0911219d.

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New potent antibacterials, fused isoxazole and pyrazole derivatives, were synthesized using 5,5-dimethylcyclohexane-1,3-dione (1) and 3-[(4-chlorobenzylidene) amino]-2-thioxoimidazolidin-4-one (2) as synthons. Aromatic aldehydes on condensation with 1 and 2 gave 2-arylidene-5,5-dimethylcyclohexane- 1,3-dione (3) and 5-arylidene-3-[(4-chlorobenzylidene)amino]-2-thioxoimidazolidin-4-one (4), respectively. Compounds 3 and 4 were forced to undergo heterocyclization reaction with nucleophilic reagents to give the title compounds. The newly synthesized heterocyles (5-8) were characterized based on t

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11

Ibtehal K. Abdullah and Meaad K. Buniya. "Preparation and Identification of some heterocyclic compounds from cyano compounds." Tikrit Journal of Pure Science 20, no. 5 (2023): 96–105. http://dx.doi.org/10.25130/tjps.v20i5.1245.

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This article included prepared cyano acetic acid hydrazid from interaction cyano ethylacetate with hydrate hydrazen, and interaction with 2- acytel thiophene and 2- acytelpyridine it will formation of hydrazide- hydrazone derivative (I, II), and through the undergo the compounds (I,II) for chain of interactions with different chemical materials then enclosed cyclo formed derivative of (arylidene ,coumarin , aryl hydrazon , thiophene ) . Prepared compounds have been studied and Identification by physical and spectral means.

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12

Tzani, Andromachi, Eftichia Kritsi, Lamprini Tsamantioti, et al. "Synthesis, Conformational Analysis and ctDNA Binding Studies of Flavonoid Analogues Possessing the 3,5-di-tert-butyl-4-hydroxyphenyl Moiety." Antioxidants 11, no. 11 (2022): 2273. http://dx.doi.org/10.3390/antiox11112273.

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Flavanones and their biochemical precursors, chalcones, are naturally occurring compounds and consist of privileged scaffolds used in drug discovery due to their wide range of biological activities. In this work, two novel flavanones (3 and 4), the arylidene flavanone 5, and the chalcone 6, displaying structural analogies with butylated hydroxytoluene (BHT), were synthesized via an aldol reaction. According to the antioxidant activity studies of the synthesized flavanones, the arylidene flavanone 5 was the most potent antioxidant (70.8% interaction with DPPH radical and 77.4% inhibition of lip

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13

Lozinskaya, Natalia A., Elena N. Bezsonova, Meriam Dubar, et al. "3-Arylidene-2-oxindoles as Potent NRH:Quinone Oxidoreductase 2 Inhibitors." Molecules 28, no. 3 (2023): 1174. http://dx.doi.org/10.3390/molecules28031174.

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The enzyme NRH:quinone oxidoreductase 2 (NQO2) plays an important role in the pathogenesis of various diseases such as neurodegenerative disorders, malaria, glaucoma, COVID-19 and cancer. NQO2 expression is known to be increased in some cancer cell lines. Since 3-arylidene-2-oxindoles are widely used in the design of new anticancer drugs, such as kinase inhibitors, it was interesting to study whether such structures have additional activity towards NQO2. Herein, we report the synthesis and study of 3-arylidene-2-oxindoles as novel NRH:quinone oxidoreductase inhibitors. It was demonstrated that

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14

Mosula, L. M., and V. S. Mosula. "IN SILICO SEARCH FOR BIOLOGICALLY ACTIVE CHEMICAL COMPOUNDS AMONG 5-ARYLIDENE SUBSTITUTED DERIVATIVES OF RHODANINE WITH BENZOTHIAZOLE MOIETY IN THE MOLECULES." Medical Science of Ukraine (MSU) 20, no. 4 (2024): 97–104. https://doi.org/10.32345/2664-4738.4.2024.11.

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Background. Knowledge about biological targets is important for effective treatment of diseases. The development of computer technology has led the emergence of a number of web tools that can help in this at the initial stages of drug development. Based on the known pharmacological potential of benzotiazole-substituted rhodanines and using modern virtual screening tools, we have carried out a targeted search for biologically active molecules among 5-arylidene substituted rhodanines with a benzothiazole moiety in molecules. The effect of various aryl substituents on the inhibitory activity of s

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15

Khatun, Sheauly, M. Z. H. Khan, Khodeza Khatun, and M. A. Sattar. "Microwave-Assisted Synthesis of Arylidene Acetophenones." Journal of Engineering 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/429785.

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An efficient synthesis of arylidene acetophenones have been achieved by using the microwave heating in comparison to the conventional heating. In this work compound 1-phenyle-3-(4-droxyphenyle)-2-propen-1-one, 1-(4-chlorophenyle)-3-phenyle-2-propen-1-one, and 1-(4-chlorophenyle)-3-(4-hydroxyphenyle)-2-propen-1-one have been synthesized by the condensation reaction between aromatic aldehydes and substituted acetophenones under microwave irradiation. The compounds of aldehydes and acetophenones were used as benzaldehyde, parahydroxybenzaldehyde, acetophenone, and parachloroacetophenone. The resu

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16

George, Riham F., Siva S. Panda, El-Sayed M. Shalaby, Aladdin M. Srour, I. S. Ahmed Farag, and Adel S. Girgis. "Synthesis and molecular modeling studies of indole-based antitumor agents." RSC Advances 6, no. 51 (2016): 45434–51. http://dx.doi.org/10.1039/c6ra07061b.

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17

Karataş, Semra, İrfan Çapan, and Süleyman Servi. "Synthesis of Indole and Benzimidazole Substituted Novel 16-Arylidene Steroid Derivatives." Letters in Organic Chemistry 16, no. 11 (2019): 884–90. http://dx.doi.org/10.2174/1570178616666190305130217.

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Novel aza-heterocyclic substituted dehydroepiandrosterone derivatives were synthesized through a three-step reaction sequence. Some new O-alkylated 4-hydroxybenzaldehydes were synthesized from the reaction of substituted benzaldehydes with dihalogen compounds which have different chain lengths. 16-Arylidene steroids were synthesized from the base-catalyzed aldol condensation of O-alkylated 4-hydroxybenzaldehydes and dehydroepiandrosterone. New indolyl and benzimidazolyl substituted steroid derivatives as hybrid molecules were obtained from the reaction of 16-arylidene steroids with indole or b

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18

Zhang, Xia, Pingping Fan, Shigui Wei, Yonghong Du, Jinjing Li, and Chengyang Shi. "Novel 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones: synthesis and antitumor activity." Mendeleev Communications 35, no. 2 (2025): 155–57. https://doi.org/10.71267/mencom.7605.

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New 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones were prepared by the Knoevenagel condensation of 1,3-thiazolidine-2,4-dione with aromatic aldehydes, conversion of the thus obtained 5-arylidene derivatives into the corresponding <em>N</em>-potassium salts, and their final <em>N</em>-acylation with acyl chlorides. The <em>in vitro</em> antitumor efficacy of the compounds was evaluated by the MTT method.

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19

Apoorva, Upadhyay, K. Srivastava S., D. Srivastava S., and Upadhyay Navneeta. "Microwave assisted synthesis of 4-thiazolidinones and its 5-arylidene derivatives : Screening of antimicrobial activity with various microorganisms." Journal of Indian Chemical Society Vol. 88, Jul 2011 (2011): 1025–31. https://doi.org/10.5281/zenodo.5785163.

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Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H. S. Gour University (A Central University), Sagar-470 003, Madhya Pradesh, India <em>E-mail</em> : upadhyay .apoorva@gmail.com Department of Chemistry, Chameli Devi Institute of Technology, Indore, Madhya Pradesh, India <em>Manuscript received 06 April 2010, revised 29 December 2010, accepted 30 December 2010</em> Several new ethyl(isonicotinamid-4-yl)acetate (1), 2-(isonicotinamid-4-yl)acetohydrazide (2), 2-(isonicotinamid- 4-yl)acetylhydrazino arylidenes (3a-j), 2-aryl-3-[(isonicotinamid-4-yl)acetamido]-4-oxo-1,3-thiazoli

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20

Shah, Shalini K., and Anju Goyal. "Design and Biological Evaluation of Novel Arylidene Hydrazides Derivatives for Anticonvulsant Activity." Asian Pacific Journal of Health Sciences 9, no. 2 (2022): 258–63. http://dx.doi.org/10.21276/apjhs.2021.9.2.51.

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The aim of present study was to design and synthesized a novel series of compound which can be evaluate for anticonvulsant, anti-microbial activity. This novel derivatives of Arylidene Hydrazides (4a-4k) were synthesised from o-chloro benzoic acid and aniline via Ulmann reaction. The synthetic method used was simple, rapid and economical found to be accurate and reproducible. The series of chemical reaction was yielded as 11 novel Arylidiene Hydrazide according to the scheme. The chemical structures of the synthesized molecules were confirmed by different lab as well as instrumental analysis l

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21

Neganova, M. E., Yu R. Aleksandrova, E. V. Sharova, et al. "Conjugates of 3,5-Bis(arylidene)-4-piperidone and Sesquiterpene Lactones Have an Antitumor Effect via Resetting the Metabolic Phenotype of Cancer Cells." Molecules 29, no. 12 (2024): 2765. http://dx.doi.org/10.3390/molecules29122765.

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In recent years, researchers have often encountered the significance of the aberrant metabolism of tumor cells in the pathogenesis of malignant neoplasms. This phenomenon, known as the Warburg effect, provides a number of advantages in the survival of neoplastic cells, and its application is considered a potential strategy in the search for antitumor agents. With the aim of developing a promising platform for designing antitumor therapeutics, we synthesized a library of conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones. To gain insight into the determinants of the biolog

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22

Ibrahim, Hany S., Soha R. Abdelhadi, and Hatem A. Abdel-Aziz. "Hydrolysis and Hydrazinolysis of Isatin-Based Ald- and Ketazines." Journal of Chemistry 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/826489.

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The hydrolysis of isatin aldazine4a–dafforded the unexpected 3,3′-(hydrazine-1,2-diylidene)bis(indolin-2-one) (5) and 1,2-di(arylidene)hydrazines6a–dthrough dual hydrolysis of4a–d. A mechanism to explain the formation of5and6a–dwas proposed. In addition, the hydrazinolysis of4a–dyielded 3-hydrazonoindolin-2-one (2) and 1,2-di(arylidene)hydrazines6a–dinstead of hydrazones17a–d, while hydrazinolysis of isatin ketazine5gave the expected 3-hydrazonoindolin-2-one (2). These results indicated the ability of the title compounds for unusual hydrolysis and hydrazinolysis reactions.

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23

Bachinsky, S. Yu, N. O. Burenkova, S. A. Andronati, and Yu V. Ishkov. "SYNTHESIS AND PROPERTIES OF NEW 1-HYDRAZINOCARBONYLMETHYL-7-BROMO-5-PHENYL-3-ARYLYDENE-1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2-ONES." Odesa National University Herald. Chemistry 28, no. 2(85) (2023): 43–51. http://dx.doi.org/10.18524/2304-0947.2023.2(85).286601.

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It is known that 1,4-benzodiazepines have neurotropic properties. Previously, we synthesized a series of 3-arylidene-1,2-dihydro-3H-1,4-benzdiazepin-2-ones 11-18 and showed that they exhibit significant analgesic activity. They also show significant affinity for central benzodiazepine receptors and TSPO receptors CNS. With this in mind, we have previously modified the series of 3-arylidene-1,2-dihydro-3H-1,4-benzodiazepin-2-ones by alkylation of 3-arylidene-1,2-dihydro-3H-1,4-benzodiazepin-2-ones with monobromoacetic acid methyl ester to the first position of the 1,4-diazepine ring to obtain 1

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24

Prasad, Malavattu G., Chapala V. Lakshmi, Naresh K. Katari, Krishnan Anand, Manojit Pal, and Sreekantha B. Jonnalagadda. "Synthesis of 2-Substituted 4-Arylidene-5(4H)-oxazolones as Potential Cytotoxic Agents in the Presence of Lemon Juice as a Biocatalyst." Combinatorial Chemistry & High Throughput Screening 22, no. 9 (2020): 625–34. http://dx.doi.org/10.2174/1386207322666191024105150.

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Background: The oxazolone class of compounds is known to exert a profound effect on malignant cell proliferation, tumor angiogenesis and /or on the established neoplastic vasculature. Additionally, these compounds are generally known to have a low tendency to interact with DNA which is not common with most of the conventional cytotoxic agents. Thus, this class of compounds is of particular interest for the discovery and development of patient-friendly anticancer agents. Objective: The initial objective of this study was to synthesize and evaluate 2-substituted 4-arylidene- 5(4H)-oxazolones for

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25

Hamama, Wafaa S., Osama M. Abd El-Magid, and Hanafi H. Zoorob. "Synthetic Entry to Tricyclic and Tetracyclic Quinuclidine Derivatives by Cycloaddition and Ring Transformation." Zeitschrift für Naturforschung B 61, no. 1 (2006): 93–100. http://dx.doi.org/10.1515/znb-2006-0119.

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The (Z)-2-arylidene-quinuclidines 5 - 8 were synthesized. Their reaction with aliphatic dibasic functional reagents in both basic and acidic conditions afforded the fused heterocycles 9, 10 and 11. However, the reaction of arylidene derivative 5 with an aromatic dibasic functional reagent gave benzimidazole 13 in lieu of the anticipated tetracyclic system, quinuclidino[3,2-e]benzo[b]-1,4-diazepine 12. Cycloadditions of 5 with different reagents gave the heterocyclic derivatives 17, 19, 22 and 23. Acid-catalyzed cyclization of 5 with excess resorcinol gave 24. Compounds 9a, 19 and 24 showed ant

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26

Dimmock, Jonathan R., Praveen Kumar, Adil J. Nazarali, et al. "Cytotoxic 2,6-bis(arylidene)cyclohexanones and related compounds." European Journal of Medicinal Chemistry 35, no. 11 (2000): 967–77. http://dx.doi.org/10.1016/s0223-5234(00)01173-9.

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Mosula, L. M., and K. S. Chudinovych. "Research of physicochemical, pharmacokinetic and druglikeness parameters of a series of 5-arylidene derivatives of 3-(benzo[d]thiazol-2-ylamino)-2-thioxothiazolidin-4-one)." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 3 (June 2025): 4–12. https://doi.org/10.32434/0321-4095-2025-160-3-4-12.

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The article presents in silico research of physicochemical, pharmacokinetic and druglikeness parameters of a series of 5-arylidene derivatives of 3-(benzo[d]thiazol-2-ylamino)-2-thioxothiazolidin-4-one. The web tool SwissADME was used for prediction of absorption, distribution, methabolism and excretion (ADME) of compounds. Based on the prediction results, it was determined that the introduction of an arylidene moiety into position 5 of the base compound with potentially high peroral availability negatively affects the passive absorption in the gastrointestinal tract. To further characterize t

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28

Nguyen, Cong T., Quang T. Nguyen, Phuc H. Dao, Thuan L. Nguyen, Phuong T. Nguyen, and Hung H. Nguyen. "Synthesis and Cytotoxic Activity against K562 and MCF7 Cell Lines of Some N-(5-Arylidene-4-oxo-2-thioxothiazolidin-3-yl)-2-((4-oxo-3-phenyl-3,4-dihydroquinazoline-2-yl)thio)acetamide Compounds." Journal of Chemistry 2019 (September 10, 2019): 1–8. http://dx.doi.org/10.1155/2019/1492316.

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Ethyl 2-((4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)thio)acetate (3) which was synthesized starting from anthranilic acid (1) via 2-thioxo-3-phenylquinazolin-4(3H)-one (2) reacted with hydrazine hydrate to afford 2-((4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide (4). Reaction of (4) with thiocarbonyl-bis-thioglycolic acid gave a new compound name N-(4-oxo-2-thioxothiazolidin-3-yl)-2-((4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)thio)acetamide (5). Knoevenagel condensation of (5) with appropriate aldehydes gave fourteen (Z)-N-(5-arylidene-4-oxo-2-thioxothiazolidin-3-yl)-2-((4-oxo-

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29

Puli, Venkat Swamy, Vukoti Kiran Kumar, Venkata Reddy Regalla, and Anindita Chatterjee. "MICROWAVE-ASSISTED SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL EVALUATION OF PHENYLACRYLAMIDE DERIVATIVES OF TRIAZOLES DERIVED FROM OXAZOLONES." Asian Journal of Pharmaceutical and Clinical Research 11, no. 7 (2018): 285. http://dx.doi.org/10.22159/ajpcr.2018.v11i7.25689.

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Objective: The aim of the present study is to synthesize novel phenylacrylamide derivatives as potent bioactive agents.Methods: Novel N-(3-(4H-1,2,4-triazol-4-ylamino)-3-oxo-1-arylidene prop-2-yl) benzimidic acids (7a-c) have been synthesized by the reaction of 4-(arylidene)-2-phenyloxazol-5(4H)-ones (5a-c) with 4-amino-1, 2, 4-triazole (6) in the presence of anhydrous sodium acetate in glacial acetic acid. Titled compounds (7a-c) were obtained in good yields using microwave technology which resulted in dramatic reductions in reaction times leading to the formation of phenylacrylamide derivati

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30

Bourahla, Khadidja, Solène Guihéneuf, Emmanuelle Limanton, et al. "Design and Microwave Synthesis of New (5Z) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5Z) 2-Amino-5-arylidene-1,3-thiazol-4(5H)-one as New Inhibitors of Protein Kinase DYRK1A." Pharmaceuticals 14, no. 11 (2021): 1086. http://dx.doi.org/10.3390/ph14111086.

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Here, we report on the synthesis of libraries of new 5-arylidene-2-thioxo-1,3-thiazolidin-4-ones 3 (twenty-two compounds) and new 2-amino-5-arylidene-1,3-thiazol-4(5H)-ones 5 (twenty-four compounds) with stereo controlled Z-geometry under microwave irradiation. The 46 designed final compounds were tested in order to determine their activity against four representative protein kinases (DYR1A, CK1, CDK5/p25, and GSK3α/β). Among these 1,3-thiazolidin-4-ones, the molecules (5Z) 5-(4-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one 3e (IC50 0.028 μM) and (5Z)-5-benzo[1,3]dioxol-5-ylmethylene-2-(p

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31

Ahmed, M., R. Sharma, D. P. Nagda, V. K. Salvi, and G. L. Talesara. "Synthetic studies of Alkoxy isoindole-1,3-diones tetra-azabenzo[f]azulenes and their Antibacterial activity." E-Journal of Chemistry 3, no. 1 (2006): 28–34. http://dx.doi.org/10.1155/2006/679374.

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3-Methylpyrazol-5-one3reacts with substituted benzaldehydes4a-din the presence of anhydrous sodium acetate to produce the corresponding 4-arylidene-5-methyl-2,4-dihydro-pyrazol-3-ones5a-dand the condensation of5a-dwith 2-bromoalkoxy-1H-isoindole-1, 3-(2H)-diones2a-cfurnished corresponding 2-[2-(4-arylidene-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)alkoxy]-isoindole-1,3-diones6a-l, which on cyclisation with o-phenylendiamine give titled compounds7a-l. All the synthesized compounds have been characterized by elemental analysis and spectral data and screened for their antibacterial properties again

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Peddaboina, Usha Rani, ANITHA SADHULA, and Ravinder Nath Anisetti. "Coumarin Imidazolone Hybrid as Inhibitor of Topoisomerase Type II and Hsp90 and as Potent Antimicrobials." Asian Journal of Chemistry 35, no. 11 (2023): 2689–702. http://dx.doi.org/10.14233/ajchem.2023.28004.

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In present study, coumarin imidazolone hybrids were synthesized on the basis of the molecular docking analysis of the compounds (11a-h) by using PyRx 0.8 software. The molecules docking studies were performed against the targets Hsp90 and human type IIA DNA topoisomerase and compared the same with standard drugs fluconazole and doxorubicin. Among all the compounds 11d (-12.7 kcal/mol) and 11f (-12.4 kcal/mol) showed good binding affinity towards human Hsp90 and 11d (-11.5 kcal/mol) and 11e (-11.4 kcal/mol) showed good binding affinity against human type IIA DNA topoisomerase. Based on the posi

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33

Momin Khan, Momin Khan, Munir Ur Rehman Munir Ur Rehman, Naveed Qadir Naveed Qadir, et al. "Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities of 5-Arylidene-N, N-Diethylthiobarbiturates." Journal of the chemical society of pakistan 42, no. 1 (2020): 134. http://dx.doi.org/10.52568/000606.

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5-Arylidene-N,N-diethylthiobarbiturates 1-25 were evaluated for their potential against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes and displayed varying degree of inhibition. Based on the IC50 values, compound 6 (IC50 = 92.51 and#177; 0.01 and#181;M) was the only active compound against acetylcholinesterase, however this compound was also weakly active against butyrylcholinesterase with an IC50 value 124.76 and#177; 0.02 and#181;M. Six compounds 1, 6, 7, 16, 17, and 18 showed weak inhibition against BChE, among them compound 18 (IC50 = 82.25 and#177; 0.07and#181;M) sh

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34

Momin Khan, Momin Khan, Munir Ur Rehman Munir Ur Rehman, Naveed Qadir Naveed Qadir, et al. "Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities of 5-Arylidene-N, N-Diethylthiobarbiturates." Journal of the chemical society of pakistan 42, no. 1 (2020): 134. http://dx.doi.org/10.52568/000606/jcsp/42.01.2020.

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5-Arylidene-N,N-diethylthiobarbiturates 1-25 were evaluated for their potential against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes and displayed varying degree of inhibition. Based on the IC50 values, compound 6 (IC50 = 92.51 and#177; 0.01 and#181;M) was the only active compound against acetylcholinesterase, however this compound was also weakly active against butyrylcholinesterase with an IC50 value 124.76 and#177; 0.02 and#181;M. Six compounds 1, 6, 7, 16, 17, and 18 showed weak inhibition against BChE, among them compound 18 (IC50 = 82.25 and#177; 0.07and#181;M) sh

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35

Saliyeva, Lesya M., Serhii M. Holota, Alina M. Grozav, et al. "Synthesis, the antiexudative and antimicrobial activity of 6-arylidene substituted imidazo[2,1-b]thiazoles." Journal of Organic and Pharmaceutical Chemistry 19, no. 2(74) (2021): 29–35. http://dx.doi.org/10.24959/ophcj.21.227378.

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Aim. To expand the range of 6-arylidene-2-methyl-2,3-dihydroimidazo[2,1-b]thiazolones as potential objects for studying the antiexudative and antimicrobial activities. Results and discussion. It has been shown that the condensation of synthetically affordable 2-methyl-2,3-dihydroimidazo[2,1-b]thiazolone with aromatic aldehydes can be successfully used for obtaining the corresponding 6-ylidene-functionalized derivatives. The biological screening of the compounds synthesized revealed that they possessed a low or moderate anti-inflammatory activity and inhibited the inflammation process in the ra

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36

Li, Ji-Tai, and Ming-Xuan Sun. "SiO2·12WO3·24H2O: a Highly Efficient Catalyst for the Synthesis of 5-Arylidene Barbituric Acid in the Presence of Water." Australian Journal of Chemistry 62, no. 4 (2009): 353. http://dx.doi.org/10.1071/ch08320.

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The condensation of aromatic aldehydes and barbituric acid catalyzed by SiO2·12WO3·24H2O in aqueous media at room temperature gave 5-arylidene barbituric acid in high yields with or without the use of ultrasound, providing a simple and efficient route to synthesis of these compounds.

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37

Chudinovych, Kateryna, Viktoria Mosula, and Liudmila Mosula. "In silico evaluation of the pharmacological potential of a series of 5- arylidene derivatives of 3-(benzo[d]thiazol-2-ylamino)-2-thioxothiazolidin-4-one." Ukrainian Scientific Medical Youth Journal 152, no. 1 (2025): 161–68. https://doi.org/10.32345/usmyj.1(152).2025.161-168.

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to develop new ligands capable of specifically targeting a biological target, researchers need knowledge about potential targets. Over the past decades, the rapid development of cheminformatics has contributed to the acceleration of this process, which led to the emergence of appropriate software. In silico tools, based on the chemical structure of a molecule, can predict the possible affinity of a ligand to a specific biomolecular target with high accuracy. The broad spectrum of biological activity of rhodanine and benzothiazole has long been known. Considering the pharmacological potential o

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38

Dodiya, Dipti, Haresh Ram, Amit Trivedi, and Viresh Shah. "An efficient, microwave-assisted, one-pot synthesis of novel 5,6,7,8-tetrahydroquinoline-3-carbonitriles." Journal of the Serbian Chemical Society 76, no. 6 (2011): 823–30. http://dx.doi.org/10.2298/jsc100702071d.

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An efficient, microwave-assisted synthesis of novel 2-alkoxy- 5,6,7,8-tetrahydroquinoline-3-carbonitriles, which have not hitherto been reported, via reactions of cyclohexanone and arylidene malononitriles in the corresponding alcohols in presence of sodium is described. All the newly synthesized compounds were characterized by the IR, 1H-NMR, 13C-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

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39

Nainesh, Kansagara, Godhasra Jagdish, Patel Mahesh, and Shah Viral. "Studies on the Biginelli reaction : Synthesis of 3,4-dihydropyrimidin-2(1H)-thiones via arylidene intermediate and one pot reaction." Journal of Indian Chemical Society Vol. 86, Apr 2009 (2009): 393–96. https://doi.org/10.5281/zenodo.5809984.

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Department of Chemistry, Kamani Science College, Amreli-365 601, Gujarat, India <em>E-mail</em> : naineshkansagara@yahoo.co.in <em>Manuscript received 30 August 2007, revised 5 August 2008, accepted 23 December 2008</em> The series of 4-aryl-6-isopropyi-5-[<em>N</em>-(3-nitrophenyl)aminocarbonyl]-3,4-dihydropyrimidin-2(1<em>H</em>)-thiones 2a-1 were prepared via arylidene (route-1) intermediates by condensing 2-arylidene-4-methyl-<em>N</em>-(3-nitrophenyl)-3-oxopentanamide and thiourea in the presence of potassium bicarbonate. Then 2a-1 were prepared by single step (route-2) in the presence of

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40

El-Hagrassey, Eman A., Ehab Abdel-Latif, and Gamal M. Abdel-Fattah. "Synthesis and efficiency of new pyridine, chromene and thiazole containing compounds as antimicrobial and antioxidant agents." Bulletin of the Chemical Society of Ethiopia 36, no. 1 (2022): 137–48. http://dx.doi.org/10.4314/bcse.v36i1.12.

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ABSTRACT. The versatile scaffold, N'-(2-cyanoacetyl)-2-hydroxybenzohydrazide (3) was utilized in the production of new pyridine, chromene and thiazole derivatives as antimicrobial and antioxidant agents. The synthetic strategy involves the treatment of precursor 3 with various arylidene-malononitrile and 3-aryl-2-cyanoacrylate compounds to furnish substituted pyridines 5 and 7. The interaction of 3 with salicylaldehyde and/or phenyl isothiocyanate followed by cyclization with chloroacetone produced the corresponding 2-imino-2H-chromene-3-carbohydrazide and (thiazol-2-ylidene-acetyl)-salicylic

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41

Pluskota, Robert, Karol Jaroch, Piotr Kośliński, et al. "Selected Drug-Likeness Properties of 2-Arylidene-indan-1,3-dione Derivatives—Chemical Compounds with Potential Anti-Cancer Activity." Molecules 26, no. 17 (2021): 5256. http://dx.doi.org/10.3390/molecules26175256.

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2-Arylidene-indan-1,3-done derivatives have very different properties, thanks to which they find various applications in science, medicine, and industry. Selected derivatives show antiviral, antibacterial, and anti-inflammatory activity. This paper presents a procedure for the synthesis of a series of indan-1,3-dione derivatives that present antiproliferative activity. The aim of the work was to develop a method of simple synthesis and purification, evaluate the fulfillment of the Lipiński’s and Veber’s rule, and determine the potential scope of application of the obtained series of compounds.

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42

Mishra, Shweta, Debashree Das, Adarsh Sahu, Shailendra Patil, Ram Kishore Agrawal, and Asmita Gajbhiye. "Phosphonate Derivatives of 3,5-bis(arylidene)-4-piperidone: Synthesis and Biological Evaluation." Anti-Infective Agents 18, no. 3 (2020): 245–54. http://dx.doi.org/10.2174/2211352517666190820143735.

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Background: 3,5-Bis(arylidene)-4-piperidinones (BAP) belong to a wide class of cross conjugated dienones. The 1,5-diaryl-3-oxo-1,4-pentadienyl fragment of the BAP moiety is responsible for the molecule's anti-tumor, antioxidant, antimicrobial and anti-inflammatory manifestations. In the present study, we present combinations of phosphonate and 3,5-bis(arylidene)-4- piperidone pharmacophores. The anti-inflammatory, anti-oxidant potential, anti-proliferative, cytotoxic potential and antimicrobial of the title compounds were evaluated in in-vitro bioassay paradigms. Methods: A novel class of phos

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T.C, Aishwarya, James Jainey, Vijay Kumar M., and B. C. Revanasiddappa. "SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES." INDIAN DRUGS 57, no. 11 (2021): 40–44. http://dx.doi.org/10.53879/id.57.11.12218.

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2 Oxo-2h-chromene-3-carbohydrazide (1) reacts with various aromatic aldehydes to give corresponding 2-oxo-2h-chromene-3-carbohydrazide arylidene hydrazides (SB1-8). Oxidative cyclization of (SB1-8) with mercuric oxide and iodine in DMF medium furnishes the title compounds 3-(5-aryl-1,3,4-oxadiazol2-yl)-2h-chromen-2-ones (2a-h). All the synthesized compounds were assigned structures on the basis of IR, 1 H-NMR and Mass spectral data. Some of the selected compounds were evaluated for In vivo anticonvulsant activity by MES and PTZ models.

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44

Naeem, Fawad, Humaira Nadeem, Aun Muhammad, Muhammad Ammar Zahid та Adil Saeed. "Synthesis, α-Amylase Inhibitory Activity and Molecular Docking Studies of 2,4-Thiazolidinedione Derivatives". Open Chemistry Journal 5, № 1 (2018): 134–44. http://dx.doi.org/10.2174/1874842201805010134.

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Introduction:2,4-Thiazolidinedione and its derivatives exhibit a variety of pharmacological activities including antidiabetic, antiviral, antifungal, anti-inflammatory, anti-cancer and aldose reductase inhibitory activities. Keeping in mind the pharmacological potential of 2,4-Thiazolidinedione derivatives as antidiabetic agents, seven arylidene derivatives of 2,4-thiazolidinedione1(a-g)and four corresponding acetic acid derivatives 2(a-d)have been synthesized by a three-step procedure.Methods:All the synthesized compounds were characterized by elemental analysis, FTIR,1HNMR, and13CNMR and fur

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45

Ibrahim, Marwa A., Riham F. George, Sahar M. Abou-Seri, and Samir M. El-Moghazy. "Synthesis of new phenolic compounds and biological evaluation as antiproliferative agents." Journal of Chemical Research 44, no. 3-4 (2019): 181–92. http://dx.doi.org/10.1177/1747519819895238.

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New series of phenolic azomethine compounds in addition to 5-arylidene thiazolidinones are synthesized and screened for their anticancer activity against the brain cancer cell line SNB-75 and non-small lung cancer cells HOP-92. The azomethine derivative 12b is the most active compound against SNB-75 displaying an IC50 value of 0.14 μM. Compounds 7b, 16a and 27d display submicromolar activity against the HOP-92 cell line with IC50 values of 0.73, 0.74 and 0.81 μM, respectively. Moreover, studying the cytotoxic effects of the most active compounds against normal lung cells WI-38 revealed that co

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46

Guarda, V. L. M., M. A. Pereira, C. A. De Simone, et al. "Synthesis and structural study of arylidene thiazolidine and benzothiazine compounds." Sulfur Letters 26, no. 1 (2003): 17–27. http://dx.doi.org/10.1080/0278611021000048712.

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Shiri, Morteza, Majid M. Heravi, and Bita Soleymanifard. "Arylidene pyruvic acids (APAs) in the synthesis of organic compounds." Tetrahedron 68, no. 33 (2012): 6593–650. http://dx.doi.org/10.1016/j.tet.2012.05.009.

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48

Dimmock, Jonathan R., and et al et al. "ChemInform Abstract: Cytotoxic 2,6-Bis(arylidene)cyclohexanones and Related Compounds." ChemInform 32, no. 14 (2001): no. http://dx.doi.org/10.1002/chin.200114152.

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49

Rudik, Daniil I., Maxim M. Perfilov, Anatolii I. Sokolov, et al. "Developing 1,4-Diethyl-1,2,3,4-tetrahydroquinoxalin-substituted Fluorogens Based on GFP Chromophore for Endoplasmic Reticulum and Lysosome Staining." International Journal of Molecular Sciences 25, no. 19 (2024): 10448. http://dx.doi.org/10.3390/ijms251910448.

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In the present study, we demonstrated that the introduction of a 1,4-diethyl-1,2,3,4-tetrahydroquinoxalin moiety into the arylidene part of GFP chromophore-derived compounds results in the formation of environment-sensitive fluorogens. The rationally designed and synthesized compounds exhibit remarkable solvent- and pH-dependence in fluorescence intensity. The solvent-dependent variation in fluorescence quantum yield makes it possible to use some of the proposed compounds as polarity sensors suitable for selective endoplasmic reticulum fluorescent labeling in living cells. Moreover, the pH-dep

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50

Desai, Nisheeth C., and Tushar J. Karkar. "Synthesis and Characterization of Some Novel Coumarin Based 2-Pyridone Heterocycles with their Broad Spectrum Antimicrobial Potency." International Letters of Chemistry, Physics and Astronomy 66 (May 2016): 1–12. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.66.1.

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The synthesis of a novel series of 6-((arylidene) amino)-2-oxo-1-((1-(2-oxo-2H-chromen-3-yl) ethylidene) amino)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles 4a-o were synthesized and structures of compounds have been elucidated by IR,1H NMR,13C NMR and mass spectral data. Antimicrobial activity was measured against certain strains of bacteria and fungi by serial broth dilution. Evaluation of antimicrobial activity shown that the compounds (4g, 4j, 4k and 4o) were found to be most active against selected bacterial strains and compounds (4d, 4m and 4n) were found to be most active against se

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