To see the other types of publications on this topic, follow the link: As-is-analysis.
Dissertations / Theses on the topic 'As-is-analysis'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 49 dissertations / theses for your research on the topic 'As-is-analysis.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
1
Carl, Uggla, and Hallström Carl-Johan. "Is It as Trustless as They Say? : A Functional Analysis of the Blockchain and Trust." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, JIBS Entrepreneurship Centre, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39715.
Full text
2
Lane, Pauline. "The frontier is long : deep ecology as theory and practice; a sociological analysis." Thesis, University of Essex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261158.
Full text
3
Mateer, Megan. "Living history as performance an analysis of the manner in which historical narrative is developed through performance /." Connect to this title online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1136660752.
Full text
4
Mateer, Shelley Megan. "Living History as Peformance: An Analysis of the Manner in which Historical Narrative is Developed through Performance." Bowling Green State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1136660752.
Full text
5
Harvey, David Ward. "The experience of working as a therapist when English is not your first language : an interpretative phenomenological analysis." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/4487/.
Full textAbstract:
Multilingualism is now considered to be the norm rather than the exception across the globe (Bialystok, 2001). Research about multilingualism has shown that self (Marcos & Urcuyo, 1979), memory (Scharuf, 2000) and emotion (Caldwell-Harris & Ayçiçeği-Dinn, 2009) are all experienced differently for multilingual individuals depending on the language they are speaking. These facets of psychological functioning are also important in managing reactions as a therapist and developing a therapeutic relationship with a client. The last in particular has been seen as an important contributor to positive therapy outcomes (Norcross, 2010). There are few national data available showing the languages spoken by regulated therapists in the UK. The present study was designed to explore these issues further. Firstly, a web-based survey was completed by 101 multilingual therapists nationwide. Within the sample of respondents, 30 countries of origin and 39 languages were represented. Subsequently, six participants were selected to take part in semi-structured interviews. The interview transcripts were analysed using Interpretative Phenomenological Analysis. Two sets of results are presented. This first focuses on experiences of delivering therapy in English as a non-native language. Three levels of themes were identified. The first consisted to two master themes: Feeling challenged and Feeling equipped. The second level consisted of three main themes: Feeling accepted in the workplace, Achieving a sense of robustness in therapy and Achieving a sense of competence in therapy. Each master theme had two sub-themes, which completed the third level. The second set of results is based on the experiences of delivering therapy in a first language having trained in English. Three themes were identified: Feeling awkward and less confident, Feeling a greater distance from the client and Developing cultural dexterity. The themes are discussed in relation to wider psychological literature. Strengths and limitations of the study are noted, and recommendations for clinical practice and future research made.
6
Söderlund, Anna, and Sanna Jonasson. "OTD as a KPI in PGGI-projects." Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-77100.
Full textAbstract:
ABB Power Grids Grid Integration, PGGI, deliver substations to external customers, the performed work is done in project form and all the projects are being tracked by several Key Performance Indicators, KPI. In this Thesis work one KPI will be investigated, which is OTD. The OTD is in form of 17 standardized milestones that are set from ABB to support the PGGI-project’s on-time-delivery. The problem that shall be investigated is the downward trend discovered regarding the OTD for the 17 milestones. This downward trend means that the PGGI-project’s ability to deliver on time is decreasing. To take on the problem a status analysis to achieve a picture of the current situation regarding the 17 milestones was done, the current situation is called As-Is. An analyze of the targeted situation regarding the milestones was also performed, which is called To-Be. When these two were made an analysis between them was also done. The result from this was that a gap between the As-Is and the To-Be situation exists. The reasons for this gap are; deficiencies in knowledge and lack of understanding regarding OTD, reporting, and unreliable data regarding the 17 milestones. Thereafter a roadmap was developed to suggest how the notified gap between As-Is and To-Be situation can be reduced and possibly be eliminated. This roadmap contains 7 improvement suggestion and an implementation plan for how some of the suggestions is recommended to be managed. This goes out to the company to perspicuous illustrate the shown gap and how to minimize it. Lean philosophy and Statistical Process Control laid as foundation for the developed improvement suggestions. An implementation of the roadmap as a template for the improvement suggestions that were developed are therefore suggested as further work.ABB Power Grids Grid Integration, PGGI, levererar transformatorstationer till externa kunder, arbetet som utförs är i projektform. Alla projekt följs upp via nyckeltal, nyckeltalet OTD som ska undersökas i detta examensarbete är i form av 17 stycken standardiserade milstolpar satta från ABB för att stötta PGGI-projektens leveranssäkerhet. Problemet som ska redas ut är den nedåtgående trenden som upptäckts i leveranssäkerheten hos de 17 milstolparna. För att ta an detta gjordes en nulägesbeskrivning samt en börlägesbeskrivning, detta visade ett gap i arbetssättet gällande de 17 milstolparna. En analys av gapet mellan nuläge och börläge genomfördes, i analysen upptäcktes brister i kunskap, förståelse, rapportering samt opålitlig data gällande de 17 milstolparna. Därefter utvecklades en plan för att föreslå hur gapet mellan börläge och nuläge ska minska för att sedan elimineras. Lean filosofi, Lean verktyg samt Statistisk Process Styrning låg som grund för de framtagna förbättringsförslagen. Den framtagna planen är tänkt att användas som grund för vidare arbete med förbättringsförslagen som tagits fram.
7
Duckworth, Andrew T. ""Golf Is Deceptively Simple and Endlessly Complicated": An Analysis of the PGA Tour's FedExCup as a Tournament Incentive Mechanism." Scholarship @ Claremont, 2012. http://scholarship.claremont.edu/cmc_theses/453.
Full textAbstract:
Nonlinear prize money structures are used in professional golf tournaments in order to induce competitors to exert a maximum level of effort. While there has been a growing amount of literature using professional golf data to test tournament theory’s basic prediction that increasing prize levels results in an increase in player effort level, no consistent narrative has emerged. Furthermore, in 2007, the PGA Tour introduced the FedExCup system, which significantly altered the ranking and prize money structure of professional golf. This paper incorporates data from the 2011 PGA tour season to analyze whether or not the introduction of the FedExCup has led to increased effort level on the part of competitors, as predicted by tournament theory. The results negate the predictions of tournament theory and suggest that an increase in tournament prize money is associated with a corresponding increase in player scores over the course of the tournament. However, these findings can be explained by examining the dramatic increase in PGA Tour prize money levels over the last two and a half decades, which has induced golfers to decrease their average level of effort.
8
Alwerdt, Jessie. "Moderation Analysis of Bowel Function among Nutrients and Physical Function or Depression, as well as whether Bowel Function is Related to Cognition in Older Adults." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6456.
Full textAbstract:
As we age, the risk for gut issues, such as smooth muscle tone, may be an underlying indirect or direct cause or risk factor for many age-related issues, such as frailty. Consequences of decreased motility and depleted epithelial barrier may result in nutrient deficiencies that may increase the risk for malnutrition (Brownie, 2006). Further, there is increasing evidence that there is a gut-brain-axis relationship that may influence cognition and mental health issues, such as depression and anxiety. While there are relationships established, the interconnections of these factors have yet to be fully understood.
This dissertation examined several relationships specific to nutrient intake, physical function, and depression in older adults while probing for a moderating effect of gut health. Looking further at this theory of the gut-brain bi-directional relationship, an additional gut health assessment was further examined to investigate the relationship with cognitive performance.
Participants were from two separate but complementary data sets. The first data set from the National Health and Nutritional Examination study included a depression outcome analytic sample and a physical function analytic sample who had valid data on nutrient intake, bowel measures, demographic characteristics, depression scores, physical function measurements, and total BMI. The depression analytic sample had a total of 1918 participants with a mean age of 73.76 years, and 1864 participants with a mean age of 73.28 years in the physical function analytic sample. The available nutrients within the data set were further broken down into several different components by a component factor analysis and each component used as a predictor. Two separate bowel measures were examined with one as a fecal incontinence measure and the other, the Bristol Stool Form Scale, as categorical (normal, constipation, or diarrhea). The second data set, the Nutraceutical Blueberry Study, had a total of 108 participants with a mean age of 73.42 years who had valid data on cognitive measures and a complete gut assessment.
Among the depression analytic sample, there were significant moderating effects of fecal incontinence between several nutrient components and depression after accounting for the control variables. An additional moderated multivariate regression with only the significant components was carried out and resulted in only Component 9 (carbohydrates, sugar, beta-cryptoxanthin, and vitamin C) and Component 12 (alcohol) having the fecal incontinence measure as a significant moderator with depression as the outcome.
Within the physical function analytical sample, the Bristol Stool Form Scale categorical measure was a significant moderator among Component 6 (MFA22_1, PFA18_4, PFA20_5, PFA22_5, and PFA 22_6) and physical function. Both the constipation and diarrhea categories were related to worse physical function, while in all groups, increase in nutrients from Component 6 resulted in better physical function.
Within the second data set, AVLT and AVLT Delay had a significant quadratic relationship with bowel function. Within the four different groups in the bowel measure (gastric function, gastrointestinal inflammation, small intestine and pancreas, and colon), gastrointestinal inflammation with a negative association and the colon category with a positive association were significant. Among the AVLT Delay, gastrointestinal inflammation was also negatively associated significant predictor.
Outcomes from the current study suggest that fecal incontinence was indicative as a moderator among the first data set, as well as significant predictor for AVLT and AVLT Delayed in relation to cognition in older adults. Although there were many relationships not found with bowel function as a moderator, the current findings suggest that more thorough measures in additional to microbiota measures could further provide possible directions for new therapeutics in psychological and cognitive therapy, as well as improving physical function in older adults.
9
Ustun, Ulas. "To What Extent Is Problem-based Learning Effective As Compared To Traditional Teaching In Science Education? A Meta-analysis Study." Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12615106/index.pdf.
Full textAbstract:
The main purpose of this meta-analysis was to investigate the effectiveness of PBL not only on student achievement and motivation in science, but also on attitudes towards science and skills in primary, secondary and higher educational levels. In addition, the effects of some moderator variables including publication type, research design, teacher effect, researcher effect, country, subject matter, school level, PBL mode, length of treatment, group size, type of questions and assessment instrument on the effectiveness of PBL were also examined in the scope of this meta-analysis. 147 effect sizes were revealed from 88 primary studies selected to be included in the meta-analysis based on the inclusion criteria. Random-effects model rather than fixed-effect model was chosen to be conducted to compute effect sizes indicating the effect of PBL on different outcomes while mixed-effect and fully random-effects model were used while performing analog ANOVA for moderator analysis. The results clearly show that PBL is more effective on different outcomes when compared to traditional teaching methods. The results indicate an overall medium mean effect size of 0.633 for PBL effectiveness. More specifically, PBL has a large impact with a large effect size of 0.820 on students&rsquoachievement in science subjects in different levels and reveals medium effect sizes of 0.566, 0.616, and 0.565 for students&rsquo
attitude towards science, motivation in science and different kinds of skills, respectively. Moderator analyses indicate that publication type, country, subject area, school level and length of treatment have a noteworthy impact on the effectiveness of PBL.
10
de, Selincourt Chris. "Where is the mind of the media editor? : an analysis of editors as intermediaries between technology and the cinematic experience." Thesis, Cardiff Metropolitan University, 2016. http://hdl.handle.net/10369/8682.
Full textAbstract:
What space does the mind occupy? A standard response to this question might be to locate the mind within the brain. However some argue that our mental processes also extend beyond the boundaries of the brain. Gallagher & Zahavi (2008) have termed these two views of the mind: internalism and externalism. In cinema, the role of editor as mediator between the cognitive activities of filmmakers, audiences and the editing equipment, makes their practice particularly suited for investigating these two seemingly incompatible views. When editors cut or join chunks of sound and image, they assemble externally what some would recognise internally as the mind’s fluctuations between one object of attention and the next. Their activities reveal a side of cinema, but also of the mind, which is usually hidden from view. The purpose of this thesis will therefore be to show how studying the process of editing contributes to our understanding of the relationship between mind and world. In order to address the question of where the editor’s mental processes are located, this study applies a phenomenographic methodology. Rather than attempt to understand cognition from a preconceived or objectively constituted position, phenomenography starts by examining variation in how a group of individuals view a particular process. This leads toward research findings that are presented from a ‘second-order perspective’ (Marton, 1981). In this thesis an understanding of how audiovisual material is selected and sequenced is revealed through fourteen interviews with British editors and directors. From the analysis of these interviews a framework emerged of five critical interrelated ways to approach the editing process. This evidence suggests that the cognitive process occurs in virtue of an editor’s physical activities, the editing equipment, plus a broader network of social and cultural relations that support the filmmaking environment. Refuting the belief that the mind is separate from the world, the editor’s mental processes are to be found distributed amongst a variety of internal and external features of their environment. The outcome of this thesis is a phenomenographic perspective on the editing process. This, I conclude, will help to inform cognitive scientists of the kinds of mental processes that editors are aware of. It also provides a wider audience of scholars with a framework for further research on variation in the process and practice of editing.
11
Björk, Elisabeth, and Jenny Wu. "PCR Analysis as a Method of Microbiological Control in Endodontic Treatment Is there a Correlation to Healing? A pilot study." Thesis, Umeå universitet, Institutionen för odontologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-153622.
Full textAbstract:
Introduction: It is scientifically established that absence of viable bacteria in the root canal prior to root filling is an important factor for a successful outcome of endodontic treatment. Culturing technique is often used to confirm a root canal free from bacteria before obturation. This technique has some unfavorable limitations. Polymerase chain reaction (PCR) is a molecular technique which can be used to analyze the endodontic microflora and enable faster analytical progress. It is however uncertain if PCR can be used to predict treatment outcome in endodontic treatment. The aim of this study is to investigate whether PCR as a method could be used to predict treatment outcome by bacterial sampling prior to root filling. Methods: During strict aseptic conditions, bacterial samples were taken in 24 single-rooted teeth on two occasions. The first samples were taken directly after access cavity was made, and the second samples were taken after the canals were treated and cleaned with antimicrobial substances, using sterile saline and paper points. The samples were transferred to fluid thioglycolate medium. Analyzes of all the samples were made with PCR-method and culturing technique. These results were correlated to healing seen in x-rays for each tooth. Results: No correlation between healing and bacterial DNA numbers prior to root filling analysis was found. Neither was a correlation found between the bacterial DNA numbers prior to treatment and bacterial numbers before root filling. Conclusions: The results indicate that PCR, as a method, cannot be used to predict the outcome of endodontic treatment.
12
Melemedjian, Ohannes, Hussein Yassine, Adia Shy, and Theodore Price. "Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment." BioMed Central, 2013. http://hdl.handle.net/10150/610218.
Full textAbstract:
BACKGROUND:Peripheral nerve injury (PNI) results in a fundamental reorganization of the translational machinery in the injured peripheral nerve such that protein synthesis is increased in a manner linked to enhanced mTOR and ERK activity. We have shown that metformin treatment, which activates adenosine monophosphate-activated protein kinase (AMPK), reverses tactile allodynia and enhanced translation following PNI. To gain a better understanding of how PNI changes the proteome of the sciatic nerve and ascertain how metformin treatment may cause further change, we conducted a range of unbiased proteomic studies followed by biochemical experiments to confirm key results.RESULTS:We used multidimensional protein identification technology (MUDPIT) on sciatic nerve samples taken from rats with sham surgery, spinal nerve ligation (SNL) surgery or SNL + 200mg/kg metformin treatment. MUDPIT analysis on these complex samples yielded a wide variety of proteins that were sorted according to their peptide counts in SNL and SNL + metformin compared to sham. These proteins were then submitted to functional annotation analysis to identify potential functional networks altered by SNL and SNL + metformin treatment. Additionally, we used click-chemistry-based labeling and purification of nascently synthesized proteins followed by MUDPIT to further identify peptides that were synthesized within the injured nerve. With these methods, we identified apolipoprotein E (ApoE) as a protein profoundly increased by PNI and further increased by PNI and metformin. This result was confirmed by Western Blot of samples from SNL rats and spared nerve injury (SNI) mice. Furthermore, we show that 7-day treatment with metformin in naive mice leads to an increase in ApoE expression in the sciatic nerve.CONCLUSIONS:These proteomic findings support the hypothesis that PNI leads to a fundamental reorganization of gene expression within the injured nerve. Our data identify a key association of ApoE with PNI that is regulated by metformin treatment. We conclude from the known functions of ApoE in the nervous system that ApoE may be an intrinsic factor linked to nerve regeneration after PNI, an effect that is further enhanced by metformin treatment.
13
From, Malcolm. "An Analysis of the way Grammar is Presented in two Coursebooks for English as a Second Language : A Qualitative Conceptual Analysis of Grammar in Swedish Coursebooks for Teaching English." Thesis, Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-43794.
Full textAbstract:
This essay aims to investigate theoretically how two currently used coursebooks, What’s Up 9 and Solid Gold 1, in a local area of Southern Sweden, present (introduces and covers) grammar. The overall aim is to investigate how grammar is presented, using the present simple and the present continuous as examples. The findings are also mapped to teaching approaches, as well as SLA (Second Language Acquisition) research, to see what approaches are favoured for teaching grammar in the first decades of the 21st century. In order to investigate the course- books, a qualitative content analysis and conceptual analysis was chosen with the presentation of grammar mapped into different categories, by using concepts for teaching and approaches used in SLA. The results show that the two proposed coursebooks favoured a FoFs (Focus on Forms) approach for presenting grammar. Furthermore, the results show that grammar is pre- sented explicitly and, if the teachers use the structures proposed in the coursebook rigidly, they automatically follow a deductive teaching procedure. When using a FoFs, explicit instructions and taking a deductive teaching approach, it may be regarded as the coursebooks suggest a grammar-translation approach as well. However, when observing other exercises connected to the reading texts in the coursebooks, it was detected that both coursebooks favoured a text- based approach for teaching, where the learners are supposed to learn the structure of different texts. In doing so, the grammatical structures are learned subconsciously and implicitly, which indicates that grammar is, in general, taught implicitly in the coursebooks, but presented (intro- duced and covered) explicitly.
14
Covic, Mirjana, and Thomas Kohler. "IT security for small and medium-sized enterprises : A didactical concept of a dynamical questionnaire." Thesis, Växjö University, School of Mathematics and Systems Engineering, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-6266.
Full textAbstract:
This master thesis has been written at the School of Mathematics and System Engineering (MSI) at Växjö University in the field of computer science. IT security has become one of the main topics of every enterprise since they all use information technology in their business. Investments have to be done in order to achieve a high protection status of the IT environments. Specially small and medium-sized enterprises need more knowledge and advisory how to handle their IT security. This thesis analyses management tools that have the goal to improve the IT security. The second and main part of the thesis is the design of a tool that should helps to solve the described problems.
15
Foley, Amanda S. "Hydration in older adults: is there a difference in self-reported healthy older adults and those with dysphagia as measured using Bioelectrical Impedance Analysis?" Thesis, Wichita State University, 2013. http://hdl.handle.net/10057/6816.
Full textAbstract:
Bioelectrical Impedance Analysis (BIA) was used to investigate body composition and hydration of older residents (65+ years) in a Continuing Care Retirement Community (CCRC). BIA is a safe, non-invasive, efficient, valid, and reliable tool that can document hydration in older adults. Participants were women who viewed themselves as healthy (n = 16) and those with dysphagia (n = 8). Participants with dysphagia were expected to be less well hydrated than those who did not have swallowing difficulties. All were tested at the same time of day after a 3-hour fast. Independent-samples t-test analyses showed no significant differences between Total Body Water (TBW), Fat Free Mass (FFM), Fat Mass (FM), and percent Body Fat (% BF) for the two groups. When compared to previously published data for age-matched women, the TBW values of the two participant groups were notably less. FFM values for both groups of participants also were less than expected. FM and % BF values were notably greater than expected. The presence of dysphagia did not appear to have an adverse effect on hydration level. This may reflect the limited number of participants with dysphagia. Alternatively, results may suggest that residential facilities are unique environments in which all residents can be considered at-risk for dehydration. If true, results support the efforts of CCRC administrators to promote person-centered care to optimize residents' health and quality of life, including adequate hydration, and suggest that BIA could be a valuable tool to facilitate the early identification of residents at-risk for dehydration.
KEYWORDS: Bioelectrical impedance analysis; dehydration; quality of life; residential facilitiesThesis (M.A.)--Wichita State University, College of Health Professions, Dept. of Communication Sciences and Disorders
16
Lund, Kristensen Toke. "Analyse af danske annonceringseffekter ved aktietilbagekøb med udlodning for øje = Analysis of Danish announcement impacts, when share repurchase is used as payout to investors /." Aarhus : Institut for Økonomi, Aarhus Universitet, 2008. http://mit.econ.au.dk/Library/Specialer/2008/20030905.pdf.
Full text
17
Goktan, Cansu. "A Comparative Analysis Of Sense Of Belonging As A Part Of Identity Of The Colonizer And The Colonized In The Grass Is Singing And My Place." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12611768/index.pdf.
Full textAbstract:
ABSTRACT
A COMPARATIVE ANALYSIS OF SENSE OF BELONGING AS A PART OF IDENTITY OF THE COLONIZER AND THE COLONIZED IN THE GRASS IS SINGING AND MY PLACE
Cansu Göktan M.A., in English Literature Supervisor: Assist. Prof. Dr. Margaret Sö
nmez May 2010, 205 pages This thesis investigates how two loosely autobiographical works unveil the effects of colonization on their major characters in terms of their identities and senses of belonging. The Grass Is Singing by Doris Lessing, a second-generation member of the colonizer, and My Place by Sally Morgan, a third-generation hybrid Australian Aborigine, are selected because both novels essentially deal with colonial issues by depicting their major characters in a process of maturation within a colonial and post-colonial framework, the former using a semi-autobiographical narrative tone and the latter using an Aboriginal version of autobiography, which integrates oral tradition and storytelling. These two books reveal that a sense of identity is closely related to a sense of belonging and that both are fundamentally affected by the colonial situation. The effects of a sense of identity and a sense of belonging, which boil down to the demise or survival of the individual, interacts with family and society, physical environment, and race issues that the thesis investigates by dedicating a chapter to each. The method used in this point-by-point comparative analysis is to approach the issues of sense of belonging and identity in a colonial context with a close reading of the two works, to find out what the texts say for themselves regarding the effect of family and society, environment, and race as depicted in The Grass Is Singing and My Place. The theoretical background that is most relevant to this study is post-colonial literary theory, although here it is taken as secondary to the close reading that is the thesis&rsquo
s primary approach to these works. Keywords: Doris Lessing The Grass Is Singing, Sally Morgan My Place, Colonial and Post-colonial Literature
18
Coetzee, Izak Jacobus. "A critical analysis as to whether a company is entitled to carry forward assessed losses if such company has traded but has derived no income therefrom." Master's thesis, Faculty of Commerce, 2021. http://hdl.handle.net/11427/33688.
Full textAbstract:
The Income Tax Act No 58 of 1962 provides for tax to be levied on an annual basis (i.e. income and expenditure are generally calculated and determined in respect of a single year of assessment). Section 20(1) makes provision for the possibility that the allowable deductions may exceed a taxpayer's income by allowing for the carrying forward of any balance of assessed loss to subsequent years of assessment. It therefore provides for taxpayers to utilise assessed losses determined in previous tax periods against the income derived in future tax periods. Our courts have decided that a company which does not trade during a specific year of assessment forfeits its right to carry forward its balance of assessed loss from the preceding year of assessment. What has been left undecided in our superior courts however (although has been considered in our Tax Courts), is whether a company would also forfeit its right to carry forward its balance of assessed loss in the event where such a company carried on a trade during the current year of assessment, but derived no income therefrom. The primary research question in this study is whether a company would be allowed to carry forward its balance of assessed loss determined at the end of its previous year of assessment to its current year of assessment, in circumstances where it derived no ‘income' from its trading activities during the current year of assessment. This study also considers, as a secondary research question, whether the recent proposals made by Treasury in terms of the Budget Speech held on 26 February 2020, would have an impact on the primary research question. In order to address the primary and secondary research questions, this study considers the wording of section 20 in the light of the guidance on interpreting fiscal statutes as provided by our courts. The study also considers the views expressed in our courts in relation to section 20(1) as well as the relevant commentary on these views. Furthermore, the study considers SARS' view on section 20 as well as whether the recent proposals made by Treasury have an impact on the carrying forward of a company's balance of assessed loss. It is concluded that in terms of the recent proposal made by Treasury, a company whose trading activities result in a loss should be unaffected by the proposed amendments, although this can only be confirmed once the proposed legislation in this regard has been made available. It is further concluded that a superior court has not yet interpreted section 20(1) in terms of the current approach to the interpretation of statutes, and it is submitted that a superior court may come to the conclusion that a company would be allowed to carry forward its balance of assessed loss determined at the end of its previous year of assessment to its current year of assessment, even though it had derived no income from its trading activities during its current year of assessment.
19
McNeil-Girmai, Elaine Azalia. "“This is our life. We can’t drive home.” An Analysis of Culturally Relevant Pedagogy as Perceived by Elementary Teachers, Students and Families in an Urban Charter School." Digital Commons at Loyola Marymount University and Loyola Law School, 2010. https://digitalcommons.lmu.edu/etd/245.
Full textAbstract:
As schools have become more diverse ethnically and linguistically, the likelihood of cultural mismatches among students, families, and teachers has increased (Frank, 1999). Culturally relevant pedagogy has at its core the understanding that incorporating students‘ culture into the practices of the school and the classroom through culturally relevant curriculum is likely to improve student cooperation, inspire a greater understanding of the educational program, and increase academic outcomes (Brown, 2004). These pedagogies have the potential to be a vital tool toward closing the achievement gap, yet the practices associated with them are in danger of meeting the same fate as multicultural education. A lack of knowledge about the theory, practice, and implementation of culturally relevant pedagogy has led to ineffective attempts to meet the needs of students most at risk (White-Clark, 2005). Using the five themes of Critical Race Theory (Solórzano & Yosso, 2001) as the theoretical framework, the research examined how teachers perceive and implement culturally relevant pedagogy, and how students and their families perceive and evaluate these practices. This research conducted at a inner city, charter elementary school was grounded on Ladson-Billings‘ work on culturally relevant pedagogy and the three concepts of knowledge that she identified that teachers must bring to the classroom and impart to their students: a) Academic achievement, b) Cultural competence, and c) Sociopolitical consciousness (Ladson-Billings, 2001). The educational significance of this study resides in an analysis of its potential to influence teaching practices in many existing classroom settings that have an ethnically diverse population of students. On a micro level, through the use of catalytic validity and ongoing dialogue with the participants, the potential arose for members of the school community to have greater input in the structuring of their children‘s education. As members of the school community engage in future decisions regarding culturally relevant strategies, these research findings offer them an informed and critical perspective to work from.
20
Muscati, Sadiq Abdul Husein Ali. "A theoretical study of the fatigue cumulative damage analysis of reinforced concrete beams as a contribution to the design of short span highway bridges in regions where traffic is not intense." Thesis, University of Southampton, 1986. https://eprints.soton.ac.uk/393994/.
Full text
21
Pecen, Pavel. "Navržení nástrojů pro řízení internetového obchodu, optimalizace a standardizace procesů pro vybraný podnik." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-124597.
Full textAbstract:
The aim of this thesis was to provide manager of a particular e-shop a practical overview of the current state of strategic and operational management and to suggest possible solutions to discovered imperfections. Within the analysis of the current state following assessments has been accomplished: evaluations of company's vision, related goals, design and implementation of the strategy, organizational structure and set of procedures in the company, analysis of jobs activities and full time equivalent analysis. In addition, key business processes of the community e-shop have been mapped with employees and costs were assigned to their various activities, thereby to obtain quantification of the average cost per order. Steps were designed to optimise key processes to improve e-shop's operational efficiency.
22
Kass, Natalie. "Science in the Sun: How Science is Performed as a Spatial Practice." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6657.
Full textAbstract:
This study analyzes how spatial organization impacts science communication at the St. Petersburg Science Festival in Florida. Through map analysis, qualitative interviews, and a close reading of evaluation reports, the author determines that sponsorship, logistics, exhibitor ambience, and map usability and design are the factors most affecting the spatial performance of science. To mitigate their effects, technical communicators can identify these factors and provide the necessary revisions when considering how science is communicated to the public.
23
Drochytka, Jan. "Vliv specifické lokality na cenu rezidenčního objektu na Brněnsku." Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-413826.
Full text
24
Penven, James C. "What is a Collegiate Way of Living Worth? Exploring the Costs and Benefits of Residential Colleges as Perceived by Faculty and Chief Housing Officers." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/73608.
Full textAbstract:
Reducing inefficiencies without compromising quality is a major challenge facing college and university leaders. Measuring efficiency and quality is often addressed through various statistical analyses (Archibald & Feldman, 2008; Flegg, Allen, & Thurlow, 2004). Researchers have also applied cost benefit analysis to measure efficiency. Collaboration is one mechanism used by university personnel to enhance efficiency and quality (Wiley, 2008). The literature on collaboration includes collaboration in research (Rigby & Elder, 2005), teaching (Kezar, 2005; Letterman & Dugan, 2004), and cross-divisional collaboration, learning communities (O’Connor & Associates, 2003). Residential colleges (where faculty live and work in residence halls) are another form of collaboration emerging across college campuses. A thorough review of the literature reveals no studies exploring the costs and benefits of residential colleges.
The purpose of this study was to understand and describe the costs and benefits of residential colleges. The theoretical framework for this study was based on Nas’ (1996) cost benefit analysis framework. Data were collected through 60-90 minute telephone interviews with live-in faculty leaders of residential colleges and chief housing officers on campuses that offer residential colleges. Participants came from 11 different campus and included 12 chief housing officers and 11 faculty members.
There are substantial institutional and individual costs associated with starting and maintaining a residential college. Institutional costs include departmental financial implications for facility renovations, staffing, and faculty incentives. Faculty principals and students bear individual costs. Impact on research, intensive time requirements for the position, and lack of recognition are costs affecting faculty. Residential college (RC) students incur additional fees and non-RC students are impacted by a diminished residential experience (as compared to their RC peers). Conversely, there are significant benefits resulting from residential colleges that may mitigate these costs. Institutions benefit from improved faculty pedagogy, expanded learning opportunities for students, and increased faculty connection to the institution. Individual benefits include positive faculty and student relationships (for faculty and students), increased understanding of students (for faculty), and faculty housing and other related incentives.Ph. D.
25
Jordánová, Ivana. "Hodnocení tepové frekvence a saturace krve kyslíkem pomocí chytrého telefonu." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2018. http://www.nusl.cz/ntk/nusl-378033.
Full text
26
Saito, Fabiano Santos. "(Multi)letramento(s) digital(is) na escola pública: reflexões sobre as práticas discursivas de professoras que se relacionaram com as tecnologias da informação e comunicação no ensino." Universidade Federal de Juiz de Fora (UFJF), 2011. https://repositorio.ufjf.br/jspui/handle/ufjf/5471.
Full textAbstract:
Submitted by isabela.moljf@hotmail.com (isabela.moljf@hotmail.com) on 2017-08-08T11:28:07Z
No. of bitstreams: 1
fabianosantosaito.pdf: 2225284 bytes, checksum: e301c7cf28a8e31d10326ef4fa1184dc (MD5)Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-08-08T18:04:15Z (GMT) No. of bitstreams: 1 fabianosantosaito.pdf: 2225284 bytes, checksum: e301c7cf28a8e31d10326ef4fa1184dc (MD5)
Made available in DSpace on 2017-08-08T18:04:15Z (GMT). No. of bitstreams: 1 fabianosantosaito.pdf: 2225284 bytes, checksum: e301c7cf28a8e31d10326ef4fa1184dc (MD5) Previous issue date: 2011-03-18
FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
O objetivo desta dissertação é investigar as práticas discursivas de três professoras que se relacionaram direta e indiretamente com as Tecnologias da Informação e Comunicação (TICs) no processo de ensino-aprendizagem. Para cumprir com esta proposta, adotamos o modelo de Multiletramentos Digitais, de Selber (2004), que congrega as várias dimensões de Letramento(s) Digital(is) e tenta explicá-los razoavelmente através de três categorias principais: Letramento Digital Funcional; Letramento Digital Crítico e Letramento Digital Retórico. Além disso, para melhor investigar as práticas discursivas das professoras pesquisadas, encontramos suporte na Teoria do Posicionamento, de acordo com a qual nós disponibilizamos lugares discursivos para nós mesmos e para os outros dentro de uma ordem moral que estabelecemos durante uma troca simbólica, construindo pontos de vista específicos através de posicionamentos (cf. HARRÉ e VAN LANGENHOVE, 1999). Metodologicamente, esta pesquisa se estrutura como um estudo de caso etnográfico (ANDRÉ, 1995; YIN, 2001; VIÉGAS, 2007), associado a uma (micro) análise do discurso (GEE et al., 1992; SACKS et al., 1974, 2005; DAVIES e HARRÉ, 1990). O contexto investigado é uma escola pública da rede municipal de ensino de Juiz de Fora-MG, localizada em um bairro periférico da cidade. As participantes são três professoras que se relacionaram direta e indiretamente com as TICs no ensino, a saber: a professora de Informática Educacional, a professora regente de turma (4º ano do Ensino Fundamental) e a professora responsável pela biblioteca escolar. Para geração de dados, utilizamos questionários, notas de campo, observação e entrevistas semi-estruturadas. O corpus de pesquisa constitui-se principalmente das transcrições das entrevistas realizadas com as participantes. Os resultados do estudo indicam que, embora as professoras tenham um posicionamento favorável ao uso das TICs no ensino, suas experiências pessoais e profissionais com tais tecnologias acabam influenciando em diferentes níveis de engajamento quanto ao projeto de inserção das TICs no processo de ensino-aprendizagem. A análise dos dados também indica um predomínio do modelo de Letramento Digital Funcional na escola investigada, o que aponta para a necessidade de se adotar perspectivas mais críticas de Letramento(s) Digital(is) no contexto educacional.
The aim of this thesis is to investigate the discursive practices of three teachers that have kept direct and indirect relationships with Information and Communication Technologies (ICT‟s) in the teaching-learning process. To accomplish with this purpose, we have adopted as theoretical framework the model of Digital Multiliteracies proposed by Selber (2004), which considers the multilayered dimensions of Digital Literacies and tries to explain them reasonably through three main levels of computer literacy: Functional Literacy, Critical Literacy, and Rhetorical Literacy. In addition, to better investigate the discursive practices of the teachers surveyed, we also have found support on Positioning Theory, according to which we provide discursive locations for ourselves and the others within a moral order that we establish during a symbolic exchange, building specific points of view inside the positions we take on (Harré and Van Langenhove, 1999). Methodologically, this research is structured as an ethnographic case study (André, 1995; Yin, 2001; Viégas, 2007) associated to a discourse (micro) analysis (Gee et al., 1992; Sacks et al., 1974, 2005; Davies and Harré, 1990). The context of this qualitative research is a public school pertaining to the municipal education system of Juiz de Fora – Minas Gerais. This school is located in a suburbian area of the city. The participants are three teachers that have kept direct and indirect relationships with ICT‟s in education, namely: the teacher of Educational Informatics, the teacher of a classroom (4th year of Brazilian elementary school) and the teacher responsible for the school library. To generate the data, we have used questionnaires, field notes, observation and semi-structured interviews. The corpus of this research consists mainly of the transcripts from interviews made with the participants. The results of this study point out that although the teachers have taken on favorable positions regarding the use of ICT‟s in education, their personal and professional experiences with such technologies tend to influence at different levels of commitment to the project of insertion of ICT‟s in the teaching-learning process. The data analysis also evinces a predominance of Functional Digital Literacy in the school investigated, which indicates the necessity for adoption of more critical perspectives regarding Digital Literacies in educational settings.
27
Costa, Ivonete Ferreira da. "INTERTEXTUALIZAÇÃO NA OBRA DE MARINA COLASANTI: O TEAR E O TECIDO." Pontifícia Universidade Católica de Goiás, 2016. http://tede2.pucgoias.edu.br:8080/handle/tede/3563.
Full textAbstract:
Submitted by admin tede (tede@pucgoias.edu.br) on 2016-12-12T17:45:59Z
No. of bitstreams: 1
IVONETE FERREIRA DA COSTA.pdf: 1144206 bytes, checksum: 112aea88b52fbaed3f56007447beaf47 (MD5)Made available in DSpace on 2016-12-12T17:46:00Z (GMT). No. of bitstreams: 1 IVONETE FERREIRA DA COSTA.pdf: 1144206 bytes, checksum: 112aea88b52fbaed3f56007447beaf47 (MD5) Previous issue date: 2016-03-23
The text brings the analysis of aspects of the literary discourse as the processes of construction of the scenes and the magical universe, in which the narratives of Marina Colasanti are realized, having as it shows the tales of the works Doze reis e a moca no labirinto do vento (2006): "The woman ramada", Uma ideia toda azul (2006): "Beyond the frame", "Between the leaves of green ó" and "Yarn after yarn". The general and specific objectives are to highlight and distinguish the encompassing and generic scenes present in the narratives, to identify the nature of the verbal sign in its relation to the nonverbal sign, and to analyze intertext resources, paratext, among others, as an artistic procedure. The narrative plans are approached, in which the characters are realized mimically, starting from the initial assumption formulated by Dominique Maingueneau. Non-verbal language is an invitation to read verbal language and vice versa. Both are associated with the signs that are constructed through the textual writing: loom and fabric. They can be seen now either explicitly or implicitly, and put in the service of a power that is realized by the act of reading. Thus, in the narrative text, there are traces of a speech in which the text is staged.
O texto traz a análise de aspectos do discurso literário como os processos de construção das cenas e o universo mágico, em que se realizam as narrativas de Marina Colasanti, tendo como mostra os contos das obras Doze reis e a moca no labirinto do vento (2006): “A mulher ramada”, Uma ideia toda azul (2006): “Além do bastidor”, “Entre as folhas do verde ó” e “Fio após fio”. Os objetivos geral e específicos são destacar e distinguir as cenas englobante e genérica presentes nas narrativas, identificar a natureza do signo verbal na sua relação com o signo não verbal e analisar recursos de intertexto, paratexto, entre outros, como procedimento artístico. Abordam-se os planos narrativos, nos quais se dá a realização dos personagens mimeticamente, partindo do pressuposto inicial formulado por Dominique Maingueneau. A linguagem não verbal é um convite à leitura da linguagem verbal e vice-versa. Ambas se associam aos signos que se constroem por meio da escritura textual: tear e tecido. Elas podem ser vistas ora de modo explícito, ora implícito, e se colocam a serviço de um poder que se realiza pelo ato de leitura. Assim, no texto narrativo, há rastros de um discurso em que o texto é encenado.
28
Tavares, Lucas Alves. "O envolvimento da proteína adaptadora 1 (AP-1) no mecanismo de regulação negativa do receptor CD4 por Nef de HIV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/.
Full textAbstract:
O Vírus da Imunodeficiência Humana (HIV) é o agente etiológico da Síndrome da Imunodeficiência Adquirida (AIDS). A AIDS é uma doença de distribuição mundial, e estima-se que existam atualmente pelo menos 36,9 milhões de pessoas infectadas com o vírus. Durante o seu ciclo replicativo, o HIV promove diversas alterações na fisiologia da célula hospedeira a fim de promover sua sobrevivência e potencializar a replicação. A rápida progressão da infecção pelo HIV-1 em humanos e em modelos animais está intimamente ligada à função da proteína acessória Nef. Dentre as diversas ações de Nef está a regulação negativa de proteínas importantes na resposta imunológica, como o receptor CD4. Sabe-se que esta ação resulta da indução da degradação de CD4 em lisossomos, mas os mecanismos moleculares envolvidos ainda são totalmente elucidados. Nef forma um complexo tripartite com a cauda citosólica de CD4 e a proteína adaptadora 2 (AP-2), em vesículas revestidas por clatrina nascentes, induzindo a internalização e degradação lisossomal de CD4. Pesquisas anteriores demonstraram que o direcionamento de CD4 aos lisossomos por Nef envolve a entrada do receptor na via dos corpos multivesiculares (MVBs), por um mecanismo atípico, pois, embora não necessite da ubiquitinação de carga, depende da ação de proteínas que compõem os ESCRTs (Endosomal Sorting Complexes Required for Transport) e da ação de Alix, uma proteína acessória da maquinaria ESCRT. Já foi reportado que Nef interage com subunidades dos complexos AP-1, AP-2, AP-3 e Nef não parece interagir com subunidades de AP-4 e AP-5. Entretanto, o papel da interação de Nef com AP-1 e AP-3 na regulação negativa de CD4 ainda não está totalmente elucidado. Ademais, AP-1, AP-2 e AP-3 são potencialmente heterogêneos devido à existência de isoformas múltiplas das subunidades codificadas por diferentes genes. Todavia, existem poucos estudos para demonstrar se as diferentes combinações de isoformas dos APs são formadas e se possuem propriedades funcionais distintas. O presente trabalho procurou identificar e caracterizar fatores celulares envolvidos na regulação do tráfego intracelular de proteínas no processo de regulação negativa de CD4 induzido por Nef. Mais especificamente, este estudo buscou caracterizar a participação do complexo AP-1 na modulação negativa de CD4 por Nef de HIV-1, através do estudo funcional das duas isoformas de ?-adaptina, subunidades de AP-1. Utilizando a técnica de Pull-down demonstramos que Nef é capaz de interagir com ?2. Além disso, nossos dados de Imunoblot indicaram que a proteína ?2-adaptina, e não ?1-adaptina, é necessária no processo de degradação lisossomal de CD4 por Nef e que esta participação é conservada para degradação de CD4 por Nef de diferentes cepas virais. Ademais, por citometria de fluxo, o silenciamento de ?2, e não de ?1, compromete a diminuição dos níveis de CD4 por Nef da membrana plasmática. A análise por imunofluorêsncia indireta também revelou que a diminuição dos níveis de ?2 impede a redistribuição de CD4 por Nef para regiões perinucleares, acarretando no acúmulo de CD4, retirados por Nef da membrana plasmática, em endossomos primários. A depleção de ?1A, outra subunidade de AP-1, acarretou na diminuição dos níveis celulares de ?2 e ?1, bem como, no comprometimento da eficiente degradação de CD4 por Nef. Além disso, foi possível observar que, ao perturbar a maquinaria ESCRT via super-expressão de HRS (uma subunidade do complexo ESCRT-0), ocorreu um acumulo de ?2 em endossomos dilatados contendo HRS-GFP, nos quais também detectou-se CD4 que foi internalizado por Nef. Em conjunto, os resultados indicam que ?2-adaptina é uma importante molécula para o direcionamento de CD4 por Nef para a via ESCRT/MVB, mostrando ser uma proteína relevante no sistema endo-lisossomal. Ademais, os resultados indicaram que as isoformas ?-adaptinas não só possuem funções distintas, mas também parecem compor complexos AP-1 com diferentes funções celulares, já que apenas a variante AP-1 contendo ?2, mas não ?1, participa da regulação negativa de CD4 por Nef. Estes estudos contribuem para o melhor entendimento dos mecanismos moleculares envolvidos na atividade de Nef, que poderão também ajudar na melhor compreensão da patogênese do HIV e da síndrome relacionada. Em adição, este trabalho contribui para o entendimento de processos fundamentais da regulação do tráfego de proteínas transmembrana no sistema endo-lisossomal.The Human Immunodeficiency Virus (HIV) is the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a disease which has a global distribution, and it is estimated that there are currently at least 36.9 million people infected with the virus. During the replication cycle, HIV promotes several changes in the physiology of the host cell to promote their survival and enhance replication. The fast progression of HIV-1 in humans and animal models is closely linked to the function of an accessory protein Nef. Among several actions of Nef, one is the most important is the down-regulation of proteins from the immune response, such as the CD4 receptor. It is known that this action causes CD4 degradation in lysosome, but the molecular mechanisms are still incompletely understood. Nef forms a tripartite complex with the cytosolic tail of the CD4 and adapter protein 2 (AP-2) in clathrin-coated vesicles, inducing CD4 internalization and lysosome degradation. Previous research has demonstrated that CD4 target to lysosomes by Nef involves targeting of this receptor to multivesicular bodies (MVBs) pathway by an atypical mechanism because, although not need charging ubiquitination, depends on the proteins from ESCRTs (Endosomal Sorting Complexes Required for Transport) machinery and the action of Alix, an accessory protein ESCRT machinery. It has been reported that Nef interacts with subunits of AP- 1, AP-2, AP-3 complexes and Nef does not appear to interact with AP-4 and AP-5 subunits. However, the role of Nef interaction with AP-1 or AP-3 in CD4 down-regulation is poorly understood. Furthermore, AP-1, AP-2 and AP-3 are potentially heterogeneous due to the existence of multiple subunits isoforms encoded by different genes. However, there are few studies to demonstrate if the different combinations of APs isoforms are form and if they have distinct functional properties. This study aim to identify and characterize cellular factors involved on CD4 down-modulation induced by Nef from HIV-1. More specifically, this study aimed to characterize the involvement of AP-1 complex in the down-regulation of CD4 by Nef HIV-1 through the functional study of the two isoforms of ?-adaptins, AP-1 subunits. By pull-down technique, we showed that Nef is able to interact with ?2. In addition, our data from immunoblots indicated that ?2- adaptin, not ?1-adaptin, is required in Nef-mediated targeting of CD4 to lysosomes and the ?2 participation in this process is conserved by Nef from different viral strains. Furthermore, by flow cytometry assay, ?2 depletion, but not ?1 depletion, compromises the reduction of surface CD4 levels induced by Nef. Immunofluorescence microscopy analysis also revealed that ?2 depletion impairs the redistribution of CD4 by Nef to juxtanuclear region, resulting in CD4 accumulation in primary endosomes. Knockdown of ?1A, another subunit of AP-1, resulted in decreased cellular levels of ?1 and ?2 and, compromising the efficient CD4 degradation by Nef. Moreover, upon artificially stabilizing ESCRT-I in early endosomes, via overexpression of HRS, internalized CD4 accumulates in enlarged HRS-GFP positive endosomes, where co-localize with ?2. Together, the results indicate that ?2-adaptin is a molecule that is essential for CD4 targeting by Nef to ESCRT/MVB pathway, being an important protein in the endo-lysosomal system. Furthermore, the results indicate that ?-adaptins isoforms not only have different functions, but also seem to compose AP-1 complex with distinct cell functions, and only the AP-1 variant comprising ?2, but not ?1, acts in the CD4 down-regulation induced by Nef. These studies contribute to a better understanding on the molecular mechanisms involved in Nef activities, which may also help to improve the understanding of the HIV pathogenesis and the related syndrome. In addition, this work contributes with the understanding of primordial process regulation on intracellular trafficking of transmembrane proteins.
29
Hamy, Anne-Sophie. "Identification of Factors Predicting Sensitivity or Resistance to Neoadjuvant Chemotherapy in Breast Cancer Neoadjuvant treatment : the future of patients with breast cancer Neoadjuvant treatment for intermediate/high-risk HER2-positive and triple-negative breast cancers: no longer an “option” but an ethical obligation Long-term outcome of the REMAGUS 02 trial, a multicenter randomised phase II trial in locally advanced breast cancer patients treated with neoadjuvant chemotherapy with or without celecoxib or trastuzumab according to HER2 status BIRC5 (survivin) : a pejorative prognostic marker in stage II/III breast cancer with no response to neoadjuvant chemotherapy Beyond Axillary Lymph Node Metastasis, BMI and Menopausal Status Are Prognostic Determinants for Triple-Negative Breast Cancer Treated by Neoadjuvant Chemotherapy Pathological complete response and prognosis after neoadjuvant chemotherapy for HER2-positive breast cancers before and after trastuzumab era: results from a real-life cohort The presence of an in situ component on pre-treatment biopsy is not associated with response to neoadjuvant chemotherapy for breast cancer Chemosensitivity, tumor infiltrating lymphocytes (TILs), and survival of postpartum PABC patients treated by neoadjuvant chemotherapy Lymphovascular invasion after neoadjuvant chemotherapy is strongly associated with poor prognosis in breast carcinoma New insight for pharmacogenomics studies from the transcriptional analysis of two large-scale cancer cell line panels Biological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis A Stromal Immune Module Correlated with the Response to Neoadjuvant Chemotherapy, Prognosis and Lymphocyte Infiltration in HER2-Positive Breast Carcinoma Is Inversely Correlated with Hormonal Pathways Stromal lymphocyte infiltration after neoadjuvant chemotherapy is associated with aggressive residual disease and lower disease-free survival in HER2-positive breast cancer Interaction between molecular subtypes, stromal immune infiltration before and after treatment in breast cancer patients treated with neoadjuvant chemotherapy COX2/PTGS2 Expression Is Predictive of Response to Neoadjuvant Celecoxib in HER2-negative Breast Cancer Patients Celecoxib With Neoadjuvant Chemotherapy for Breast Cancer Might Worsen Outcomes Differentially by COX-2 Expression and ER Status: Exploratory Analysis of the REMAGUS02 Trial Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS129.
Full textAbstract:
La chimiothérapie néoadjuvante (CNA) est utilisée dans les cancers du sein agressifs ou localement avancés (CS). Au delà des bénéfices cliniques, elle représente une opportunité pour monitorer in vivo la sensibilité d’une tumeur à un traitement.A partir de l’analyse de sets de données de patients traités par CNA, nous souhaitons identifier des mécanismes associes à la résistance ou sensibilité au traitement. Dans la première partie, nous avons évalué des paramètres, cliniques, anatomopathologiques et transcriptomiques. Nous avons démontré que des éléments non explorés comme la présence d’embols après CNA revêtaient une information pronostique importante. Dans une 2ème partie, nous avons analysé l’impact de l’infiltrat immunitaire dans le cancer du sein, et avons décrit les changements observés entre des échantillons avant et après CNA. Nous avons montré que l’impact pronostique des TILs était différent avant et après CNA, et était opposé dans les CS triple négatif ou HER2-positif. Finalement, nous avons analysé l’impact des comédications pendant la CNA. Nous avons trouvé des effets positifs – via l’augmentation de l’infiltrat immunitaire et la réponse au traitement – et des effets négatifs avec des effets délétères dans certains sous groupes de patients. En conclusion, la situation néoadjuvante représente une plateforme pour générer et potentiellement valider des hypothèses de recherche. La mise à disposition de jeux de données de patients traités par chimiothérapie néoadjuvante constituerait une ressource majeure pour accélérer la recherche contre le cancer du seinNeoadjuvant chemotherapy (NAC i.e. chemotherapy before surgery) is increasingly being used for aggressive or locally advanced breast cancer (BCs). Beyond clinical benefits, it represents an opportunity to monitor in vivo sensitivity to treatment. Based on the analysis of datasets of BCs patients treated with NAC, we aimed at identifying mechanisms associated with resistance or sensitivity to treatment.In the first part, we evaluated biological, clinical, pathological and transcriptomic patterns. We demonstrated that unexplored pathological features such as post-NAC lymphovascular invasion may carried an important prognostic information.In a second part, we analyzed impact of imune infiltration in BC and we described extensively the changes of tumor infiltrating lymphocytes (TILs) between pre and post-NAC samples. We showed that the prognostic impact of TILs was different before and after NAC, and was opposite in TNBC and HER2-positive BCs. Finally, we investigated the impact of comedications use during NAC. We found both positive effects - while enhancing immune infiltration and response to treatment - and negative effects with deleterisous oncologic outcomes in specific patients subgroups. In conclusion, the neoadjuvant setting represents a platform to both generate and potentially validate research hypotheses aiming at increasing the efficacy of treatment. The public release of real-life datasets of BC patients treated with NAC would represent a major resource to accelerate BC research
30
Gomes, José Osmar. "Configurações identitárias de uma autarquia pública no contexto da defesa e inspeção agropecuária na ótica dos gestores." reponame:Repositório Institucional da UFES, 2015. http://repositorio.ufes.br/handle/10/1685.
Full textAbstract:
Submitted by Elizabete Silva (elizabete.silva@ufes.br) on 2015-08-19T19:56:31Z
No. of bitstreams: 2
license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)
CONFIGURAÇÕES IDENTITÁRIAS DE UMA AUTARQUIA PÚBLICA NO CONTEXTO DA DEFESA SANITÁRIA E INSPEÇÃO AGROPECUÁRIA NA ÓTICA DOS GESTORES.pdf: 1758376 bytes, checksum: 8f37e789f831e4f7fd3a3c884fcfd1c4 (MD5)Approved for entry into archive by Morgana Andrade (morgana.andrade@ufes.br) on 2016-01-07T13:27:17Z (GMT) No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) CONFIGURAÇÕES IDENTITÁRIAS DE UMA AUTARQUIA PÚBLICA NO CONTEXTO DA DEFESA SANITÁRIA E INSPEÇÃO AGROPECUÁRIA NA ÓTICA DOS GESTORES.pdf: 1758376 bytes, checksum: 8f37e789f831e4f7fd3a3c884fcfd1c4 (MD5)
Made available in DSpace on 2016-01-07T13:27:17Z (GMT). No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) CONFIGURAÇÕES IDENTITÁRIAS DE UMA AUTARQUIA PÚBLICA NO CONTEXTO DA DEFESA SANITÁRIA E INSPEÇÃO AGROPECUÁRIA NA ÓTICA DOS GESTORES.pdf: 1758376 bytes, checksum: 8f37e789f831e4f7fd3a3c884fcfd1c4 (MD5) Previous issue date: 2015
Esta dissertação tem por objetivo compreender como as transformações no contexto da defesa sanitária e inspeção agropecuária entre 1996 e 2014 se relacionam com as configurações identitárias do Idaf manifestadas por gestores nesse contexto. Trata-se de uma pesquisa qualitativa que descreve os processos identitários da organização por um olhar interpretativista, pelo entendimento das relações simbólicas que permeiam essa organização, observados em discursos dos sujeitos. Para coleta dos dados foram utilizadas pesquisa documental e entrevistas semiestruturadas individuais. As entrevistas foram realizadas com cinco sujeitos da organização nos meses de setembro e outubro de 2014. O método de análise foi a Análise de Conteúdo (KRIPPENDORFF, 1990) que busca investigar dados textuais através de técnicas que permitam compreendê-los com seus significados, referências, valorações e intenções. Pretendeu-se contribuir, com esse estudo, para a compreensão da identidade organizacional, em uma organização pública, no contexto da defesa sanitária e inspeção agropecuária. Os resultados permitiram identificar o Idaf como único e distinto de outras organizações e como essa identificação está relacionada às transformações do contexto agropecuário.
This research aims to understand how changes in the context of health protection and agriculture inspection between 1996 and 2014 relate to the Idaf identity configurations expressed by managers in this context. It is a qualitative research that seek to describe the identity processes of the organization by an interpretive look at understanding the symbolic relations that permeate this organization, observed in speeches of the subjects. For data collection were used desk research and semi-structured individual interviews. Interviews were conducted with five subjects of the organization in the months of September and October 2014. The analysis method was content analysis (KRIPPENDORFF, 1990) that investigates textual data through techniques to understand them with their meanings, references , valuations and intentions. It was intended to contribute to this study, for understanding the organizational identity in a public organization in the context of health protection and agricultural inspection. The results showed the Idaf as unique and distinct from other organizations and how this identification is related to change in agricultural context.
31
Bonnevie, Tristan. "Nouveaux outils et optimisation des outils existants pour la réhabilitation respiratoire et la ré-autonomisation des patients atteints d'un handicap ventilatoire. Chronic obstructive pulmonary disease Six-minute stepper test to set pulmonary rehabilitation intensity in patients with COPD - a retrospective study Can the six-minute stepper test be used to determine the intensity of endurance training in early stage COPD : a multicenter observational study The six-minute stepper test is related to muscle strength but cannot substitute for the one repetition maximum to prescribe strength training in patients with COPD People undertaking pulmonary rehabilitation are willing and able to provide accurate data via a remote pulse oximetry system : a multicentre observational study Mid-term effects of pulmonary rehabilitation on cognitive function in people with severe chronic obstructive pulmonary disease NIV is not adequate for high intensity endurance in COPD Home-based neuromuscular electrical stimulation as an add-on to pulmonary rehabilitation does not provide further benefits in patients with chronic obstructive pulmonary disease : a multicenter randomized trial Lumbar transcutaneous electrical nerve stimulation to improve exercise performance in COPD patients Advanced telehealth technology improves in-home pulmonary rehabilitation for people with stable chronic obstructive pulmonary disease : a systematic review Nasal high flow for stable patients with chronic obstructive pulmonary disease : a systematic review and meta-analysis." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMR024.
Full textAbstract:
La réhabilitation respiratoire (RR) est recommandée dans la prise en soin des patients atteints d’un handicap ventilatoire afin d’améliorer leur qualité de vie. Malgré une efficacité clairement établie, très peu de patients en bénéficient et les modalités optimales d’entrainement restent à définir. L’utilisation des outils existants et des nouveaux outils pour optimiser l’accès au programme et ses effets représentent des développements majeurs qui méritent d’être évalués. Dans le cadre de cette thèse, nous avons cherché à aborder ces deux problématiques (1) en tentant de proposer un modèle de RR délocalisée hors des centres tout en évaluant les freins à ce modèle et (2) en explorant la place de différents adjuvants à la RR afin d’en optimiser les bénéfices. Dans la première partie, nous avons montré, à travers plusieurs études rétrospectives et une contribution originale prospective multicentrique, que le test stepper de six minutes peut être utilisé pour prescrire l’entrainement en endurance, particulièrement pour les patients présentant une forme légère à modérée de bronchopneumopathie chronique obstructive (BPCO), mais pas pour prescrire le renforcement musculaire. Par ailleurs, nous avons montré dans une population de 105 patients adressés en RR que l’utilisation d’un dispositif de telemonitoring était faisable, valide et largement accepté. Enfin, nous avons exploré la prévalence des dysfonctions cognitives, autre conséquence systémique de la BPCO qui pourrait compromettre la délocalisation du programme, et avons montré que cette prévalence était très élevée (environ 75% des patients) mais que ces troubles cognitifs pouvaient s’améliorer après la RR et ne semblaient pas influencer l’utilisation d’un dispositif de telemonitoring. Dans la seconde partie, nous avons évalué la place de différents adjuvants à la RR utilisés pour en potentialiser les bénéfices. Dans une étude en cross-over menée chez 21 patients atteints de BPCO, nous avons montré que la ventilation non invasive ne permettait pas d’améliorer la capacité à l’exercice en endurance en raison d’une limitation technologique du ventilateur. A travers une étude contrôlée randomisée multicentrique menée chez 73 patients atteints de BPCO sévère à très sévère, nous avons montré que la stimulation électrique excito-motrice à domicile, réalisée en plus d’un programme de RR, n’apportait pas davantage de bénéfices sur la qualité de vie ou la capacité à l’exercice. Enfin, à travers une étude randomisée en cross-over et en double aveugle menée chez 10 patients, nous n’avons pas pu montrer l’intérêt de la stimulation électrique nerveuse transcutanée pour améliorer leur capacité à l’exercice en endurance. Enfin, dans la dernière partie, nous avons présenté les recherches actuellement menées au sein de notre laboratoire, faisant suite aux contributions originales décrites au cours de cette thèse, ainsi que de nouvelles pistes de recherche afin de poursuivre les thématiques explorées. Ainsi, deux revues de littérature et méta-analyses (l’une d’elle portant sur le haut débit nasal et l’autre sur l’utilisation des technologies de santé avancées pour réaliser la RR respiratoire à domicile) serviront de base pour de futurs travauxPulmonary rehabilitation (PR) is recommended in the management of subjects with ventilatory impairment to improve their quality of life. Although a large body of evidence support its use, only few subjects benefit from it and the optimal training modality has not been determined yet. In this context, the use of new and existing tools to optimize access as well as the effects of the program are major developments that deserve to be studied. As part of this thesis, we sought to explore these two major issues (1) by considering a rehabilitation model relocated outside the PR centres while assessing the obstacles to this model and (2) exploring the effectiveness of different add-on to PR in further optimizing the benefits of the program. In the first part, we have shown, through several retrospective studies and an original prospective multicentre contribution, that the six-minute stepper test can be used to prescribe endurance training, particularly for those patients with a mild to moderate chronic obstructive pulmonary disease (COPD), but not to prescribe muscle strengthening. Furthermore, we have shown in a cohort of 105 subjects referred for PR that the use of a remote tele monitoring device was feasible, valid and widely accepted. Finally, we explored the prevalence of cognitive dysfunction, another systemic impairment of COPD that could compromise the relocation of the program, and showed that it was a very common condition (around 75% of the subjects) but that it could improve following PR and did not seem to influence the use of a remote tele monitoring device. In the second part, we evaluated the effects of different add-on used to potentiate the benefits of the PR program. In a cross-over study of 21 COPD patients, we showed that non-invasive ventilation did not improve endurance exercise capacity due to technological limitation of the ventilator. Through a multicentre randomized controlled study carried out in 73 patients with severe to very severe COPD, we have shown that neuromuscular electrical stimulation at home, performed in addition to a PR program, did not provide further benefits on quality of life or exercise capacity. Finally, through a randomized cross-over double-blind study carried out in 10 patients, we were unable to show the effectiveness of transcutaneous nerve electrical stimulation in improving their endurance exercise capacity. Finally, in a last part, we highlighted the research currently carried out in our laboratory following the original contributions described during this thesis, as well as new area of research in order to pursue the themes explored. Thus, two systematic reviews and meta-analysis (the first about nasal high flow therapy in subjects with stable COPD and the second about the use of advanced telehealth technologies to deliver PR) will serve as a basis for future research
32
Oliveira, Verónica Alexandra Antunes. "Ferramentas de apoio à tradução científica: uma abordagem comparativa." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17031.
Full textAbstract:
Mestrado em Tradução Especializada - Ciências da SaúdeAtualmente, os tradutores, de modo a produzirem traduções num intervalo de tempo mais curto e com elevada qualidade, necessitam de um conjunto de recursos como, por exemplo, sistemas de tradução assistida por computador, programas de referência linguística ou sistemas de tradução automática. Por conseguinte, o presente Projeto terá como objetivo abordar a respetiva utilização prática num contexto profissional da área da tradução científica (em particular Ciências da Saúde), através de uma exposição teórica e de uma análise comparativa prática das funcionalidades, das vantagens, das desvantagens e dos eventuais problemas resultantes da utilização de ferramentas distintas de tradução assistida por computador
Nowadays, translators need a range of computer resources such as computer-assisted translation, linguistic reference and machine translation tools, in order to produce a high quality translation in a shorter period of time. The purpose of this Project is to address their practical use in a professional context, within the scope of scientific translation (particularly Health Sciences), by providing a theoretical presentation and a comparative analysis of the features, advantages, disadvantages, and potential problems arising from the use of different computer-assisted translation tools.
33
Fujdiak, Radek. "Analýza a optimalizace datové komunikace pro telemetrické systémy v energetice." Doctoral thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-358408.
Full textAbstract:
Telemetry system, Optimisation, Sensoric networks, Smart Grid, Internet of Things, Sensors, Information security, Cryptography, Cryptography algorithms, Cryptosystem, Confidentiality, Integrity, Authentication, Data freshness, Non-Repudiation.
34
Lvovschi, Virginie-Eve. "Titration morphinique inhalée aux Urgences : modernisation de la prise en charge des douleurs sévères de l'adulte Targeting moderate pain in healthy volunteers by individual calibration of a nociceptive flexion reflex model Proposer un "modèle" de douleur provoquée par Electromyogramme pour optimiser les outils antalgiques aux urgences Nebulized versus intravenous morphine titration for the initial treatment of severe acute pain in the emergency department : study protocol for a multicenter, prospective randomized and controlled trial, CLIN-AEROMORPH Inhaled versus intravenous opioid dosing for the initial treatment of severe acute pain in the emergency department : pharmacological intermediate results of the CLIN-AEROMORPH french study Toward new eligibility criteria for ontravenous morphine in the French Emergency Department : Evaluation of physicians' bedside rationalization of opioid titration protocols Analysis of bedside determinisms leading to under-prescription of morphine titration in the Emergency Department : EPIMORPH study Medico-economic study of pain in an emergency department : a targeted literature review Opioid reflex at triage is not a solution for opioid-naive patients in emergency departments A systemic approach to complete the multimodal assessment model of pain Intravenous morphine titration to treat severe pain in the ED Morphine consumption is not modified in patients with severe pain and classified by the DN4 score as neuropathic Prise en charge de la douleur aiguë spontanée de l'adulte aux urgences." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMR013.
Full textAbstract:
Notre objectif était d’optimiser la prise en charge de la douleur aiguë sévère en médecine d’urgence. La titration morphinique intraveineuse qui fait actuellement référence doit se moderniser pour répondre aux nouveaux enjeux de la pratique en même temps que l’on doit garantir une balance bénéfice risque inchangée dans la lutte contre l’oligoanalgésie. Le travail décrit dans cette thèse, constitue une première étape d’évaluation d’une alternative nébulisée à la titration morphinique, à travers 3 études cliniques (AEROMORPH1, CLIN-AEROMORPH, EPIMORPH) et l’étude de son contexte dans la littérature. Des travaux chez le volontaire sain ont permis d’établir un mode opératoire avec une technique aérosol simple et accessible, de courte durée (5 min), que l’on peut répéter en titration (toutes les 10 min). Sa faisabilité est en voie d’être confirmée à grande échelle dans une étude multicentrique clinique et sa non-infériorité en termes d’efficacité est en cours d’évaluation. Des données pharmacologiques chez le volontaire sain et chez les patients confirment une concentration sanguine en morphine proche des concentrations efficaces observées en intraveineux (1 à 120 ng/ml dans CLIN-AEROMORPH), ce qui est déjà un résultat positif démontré par nos travaux. Par ailleurs, sur le plan de son éligibilité, nos données observationnelles et de simulation de décision, associées aux données médico-économiques que nous avons analysées dans la littérature, suggèrent la nécessité de baser son indication autrement que sur la simple évaluation par EVA/EN à l’accueil. Dans ce travail nous montrons que la pratique des praticiens témoigne aujourd’hui de leur manque d’adhésion au déclenchement systématique de la prescription d’opiacés Iv titrés par l’autoévaluation de la douleur sévère (de 6 à 20% de respect des critères SFMU, 61% de réinterprétation des scores EVA/EN). Si la titration aérosol est uniquement proposée en starter de la titration morphinique sans moderniser les algorithmes de décision de prescription opiacée dans les protocoles d’urgences, il est probable que cette nouvelle proposition thérapeutique ne résoudra qu’une partie de la problématique actuellement posée. Une prise en charge pharmacologique la plus individualisée possible est plus que jamais pertinente, avec une prescription ciblée de la titration morphinique selon la typologie du patient, en plus d’une priorisation par typologie douloureuse. En développant un « modèle douleur » original chez le volontaire sain, nous avons d’ailleurs mis en lumière des profils de patients « hyperesthésiques » et « endurants », sur le plan neurophysiologique et biochimique, qui sont sûrement retrouvés en pratique clinique quotidienne. L’ensemble de ces éléments doivent donc être pris en compte pour améliorer la prise en charge de la douleur en médecine d’urgence, avec une vision plus systémique, et davantage d’études dédiées, utilisant des méthodes d’évaluation innovantes mêlant critères quantitatifs robustes et qualitatifs exhaustifsOur goal was to optimize the management of severe acute pain in emergency medicine. Intravenous morphine titration, which is currently the referent method, must be modernised to meet the new challenges of practice while at the same time, we must keep guaranteeing an unchanged risk-benefit balance in the fight against oligoanalgesia. Our work, described in this thesis, has been a cornerstone for the evaluation of a nebulized alternative solution to emergencies through 3 clinical studies, (AEROMORPH1, CLIN-AEROMORPH, EPIMORPH), and study of its contextualisation in literature. Work in healthy volunteers allowed us to establish a simple and accessible procedure for aerosol, of short duration (5 min), which can be repeated in titration procedures (every 10 min). Its feasibility is likely to be confirmed on our multicentre clinical study at a large scale and its efficacy, by a non-inferiority design of study is being evaluated. Pharmacological data in healthy volunteers and in patients confirm a blood morphine concentration close to the effective blood concentrations observed by intravenous administration (CLIN-AEROMORPH: 1-20 ng/ml), which is already a positive result demonstrated by our work. Moreover, regarding eligibility, our observational study, combined to a experiment about decision mechanisms, combined with the analysis of medico-economic data in literature, suggest the need to base its indication on more than just the simple VAS/NRS assessment at triage. In this work we showed that emergency practitioners’ practice today underlines their lack of adherence to the systematic initiation of intravenous morphine titration by patient self-assessment of severe pain (compliance with SFMU criteria 6 to 20%, re-assessment of VAS/NRS scores 61%). If nebulized morphine titration is only proposed as a starter for morphine titration without modernising the algorithms for opiate prescription decision in emergency protocols, it is likely that this new therapeutic proposal will only solve part of the current problem. Targeted pharmacological management, as individualised as possible, is more relevant than ever, with prescription of morphine titration according to the patient's typology, in addition to prioritisation by pain typology. By developing an original pain model in healthy volunteers, we have also highlighted profiles of "pain sensitive" and "enduring" patients, according to neurophysiological and biochemical data, that are certainly represented in daily clinical practice. Therefore, all these components should be taken into account to improve pain management in emergency medicine, with a more systemic vision and more dedicated studies using innovative evaluation methods, combining robust quantitative criteria with comprehensive qualitative criteria
35
Teng, Sin Yong. "Intelligent Energy-Savings and Process Improvement Strategies in Energy-Intensive Industries." Doctoral thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-433427.
Full textAbstract:
S tím, jak se neustále vyvíjejí nové technologie pro energeticky náročná průmyslová odvětví, stávající zařízení postupně zaostávají v efektivitě a produktivitě. Tvrdá konkurence na trhu a legislativa v oblasti životního prostředí nutí tato tradiční zařízení k ukončení provozu a k odstavení. Zlepšování procesu a projekty modernizace jsou zásadní v udržování provozních výkonů těchto zařízení. Současné přístupy pro zlepšování procesů jsou hlavně: integrace procesů, optimalizace procesů a intenzifikace procesů. Obecně se v těchto oblastech využívá matematické optimalizace, zkušeností řešitele a provozní heuristiky. Tyto přístupy slouží jako základ pro zlepšování procesů. Avšak, jejich výkon lze dále zlepšit pomocí moderní výpočtové inteligence. Účelem této práce je tudíž aplikace pokročilých technik umělé inteligence a strojového učení za účelem zlepšování procesů v energeticky náročných průmyslových procesech. V této práci je využit přístup, který řeší tento problém simulací průmyslových systémů a přispívá následujícím: (i)Aplikace techniky strojového učení, která zahrnuje jednorázové učení a neuro-evoluci pro modelování a optimalizaci jednotlivých jednotek na základě dat. (ii) Aplikace redukce dimenze (např. Analýza hlavních komponent, autoendkodér) pro vícekriteriální optimalizaci procesu s více jednotkami. (iii) Návrh nového nástroje pro analýzu problematických částí systému za účelem jejich odstranění (bottleneck tree analysis – BOTA). Bylo také navrženo rozšíření nástroje, které umožňuje řešit vícerozměrné problémy pomocí přístupu založeného na datech. (iv) Prokázání účinnosti simulací Monte-Carlo, neuronové sítě a rozhodovacích stromů pro rozhodování při integraci nové technologie procesu do stávajících procesů. (v) Porovnání techniky HTM (Hierarchical Temporal Memory) a duální optimalizace s několika prediktivními nástroji pro podporu managementu provozu v reálném čase. (vi) Implementace umělé neuronové sítě v rámci rozhraní pro konvenční procesní graf (P-graf). (vii) Zdůraznění budoucnosti umělé inteligence a procesního inženýrství v biosystémech prostřednictvím komerčně založeného paradigmatu multi-omics.
36
Nogueira, Leila de Mello Yañez. "Estabilidade versus flexibilidade: a dicotomia necessária à inovação na gestão de recursos humanos em uma organização pública, estatal eestratégica como Bio-Manguinhos / Fiocruz." reponame:Repositório Institucional da FIOCRUZ, 2009. https://www.arca.fiocruz.br/handle/icict/2500.
Full textAbstract:
Made available in DSpace on 2011-05-04T12:36:29Z (GMT). No. of bitstreams: 0
Previous issue date: 2009Este trabalho propõe analisar o fenômeno da terceirização desenvolvido ao longo das duas últimas décadas em Bio-Manguinhos. Trata-se de um estudo de caso realizado na unidade de produção de vacinas e reagentes para diagnóstico da Fundação Oswaldo Cruz. Inicialmente foi realizado um estudo de cenário, analisando a política de gestão do trabalho desenvolvida pelo Estado brasileiro para as instituições públicas. A seguir, a análise passou a verificar a inserção da Fiocruz nessas políticas, desde a sua criação e no decorrer de vigência de diferentes formas de contratação, alternando da extrema rigidez para a total flexibilidade sempre com foco na gestão do trabalho, e, como essas políticas se refletiram no desempenho de Bio-Manguinhos. Baseado no contexto da conformação do Estado e na análise do desempenho da unidade, o trabalho critica a falta de planejamento e de prospecção dessas políticas, que favoreça a inovação de processos, produtos e procedimentos e o desempenho pleno de uma unidade de produção de insumos para a saúde, tão necessários ao atendimento das necessidades da população brasileira. Critica também, a ausência de um modelo de Estado consolidado que sirva de arcabouço à formulação dessas políticas. Devido às fortes críticas dos órgãos de controle acerca da extrapolação dos limites da terceirização praticada nas últimas duas décadas e à falta de definição clara desses marcos legais, o trabalho apresenta uma metodologia baseada nas atribuições dos cargos do plano de carreiras da Fiocruz e culmina com a apresentação de uma matriz de atribuições passíveis de serem realizadas por contratação indireta. Conclui pela necessidade de convivência de dois quadros de trabalhadores: um permanente formado por servidores, estáveis e de carreira e outro flexível, executado por contratação indireta, de caráter eventual, temporário ou de apoio às atividades relacionadas à missão de Bio-Manguinhos. O trabalho ainda sugere a aplicação da mesma metodologia às demais unidades da Fiocruz e que a instituição afirme, frente aos órgãos de controle, quais atividades que ela precisa manter no quadro de servidores permanente e quais ela quer delegar a terceiros sem contudo, ferir a legislação vigente. Por fim, constata-se que a metodologia apresentada ameniza, mas não resolve o problema, dessa forma, recomenda-se à Fiocruz buscar mecanismos que altere o modelo de gestão pelo qual está submetida a fim de viabilizar as duas formas de incorporação de mão-de-obra.
37
Moreira, Ana Sofia Pereira. "Study of modifications induced by thermal and oxidative treatment in oligo and polysaccharides of coffee by mass spectrometry." Doctoral thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17074.
Full textAbstract:
Doutoramento em BioquímicaOs polissacarídeos são os componentes maioritários dos grãos de café verde e torrado e da bebida de café. Os mais abundantes são as galactomananas, seguindo-se as arabinogalactanas. Durante o processo de torra, as galactomananas e arabinogalactanas sofrem modificações estruturais, as quais estão longe de estar completamente elucidadas devido à sua diversidade e à complexidade estrutural dos compostos formados. Durante o processo de torra, as galactomananas e arabinogalactanas reagem com proteínas, ácidos clorogénicos e sacarose, originando compostos castanhos de alto peso molecular contendo nitrogénio, designados de melanoidinas. As melanoidinas do café apresentam diversas atividades biológicas e efeitos benéficos para a saúde. No entanto, a sua estrutura exata e os mecanismos envolvidos na sua formação permanecem desconhecidos, bem como a relação estrutura-atividade biológica. A utilização de sistemas modelo e a análise por espectrometria de massa permitem obter uma visão global e, simultaneamente, detalhada das modificações estruturais nos polissacarídeos do café promovidas pela torra, contribuindo para a elucidação das estruturas e mecanismos de formação das melanoidinas. Com base nesta tese, oligossacarídeos estruturalmente relacionados com a cadeia principal das galactomananas, (β1→4)-Dmanotriose (Man3), e as cadeias laterais das arabinogalactanas, (α1→5)-Larabinotriose (Ara3), isoladamente ou em misturas com ácido 5-Ocafeoilquínico (5-CQA), o ácido clorogénico mais abundante nos grãos de café verde, e péptidos compostos por tirosina e leucina, usados como modelos das proteínas, foram sujeitos a tratamento térmico a seco, mimetizando o processo de torra. A oxidação induzida por radicais hidroxilo (HO•) foi também estudada, uma vez que estes radicais parecem estar envolvidos na modificação dos polissacarídeos durante a torra. A identificação das modificações estruturais induzidas por tratamento térmico e oxidativo dos compostos modelo foi feita por estratégias analíticas baseadas principalmente em espectrometria de massa, mas também em cromatografia líquida. A cromatografia de gás foi usada na análise de açúcares neutros e ligações glicosídicas. Para validar as conclusões obtidas com os compostos modelo, foram também analisadas amostras de polissacarídeos do café obtidas a partir de resíduo de café e café instantâneo. Os resultados obtidos a partir dos oligossacarídeos modelo quando submetidos a tratamento térmico (seco), assim como à oxidação induzida por HO• (em solução), indicam a ocorrência de despolimerização, o que está de acordo com estudos anteriores que reportam a despolimerização das galactomananas e arabinogalactanas do café durante a torra. Foram ainda identificados outros compostos resultantes da quebra do anel de açúcares formados durante o tratamento térmico e oxidativo da Ara3. Por outro lado, o tratamento térmico a seco dos oligossacarídeos modelo (individualmente ou quando misturados) promoveu a formação de oligossacarídeos com um maior grau de polimerização, e também polissacarídeos com novos tipos de ligações glicosídicas, evidenciando a ocorrência de polimerização através reações de transglicosilação não enzimática induzidas por tratamento térmico a seco. As reações de transglicosilação induzidas por tratamento térmico a seco podem ocorrer entre resíduos de açúcares provenientes da mesma origem, mas também de origens diferentes com formação de estruturas híbridas, contendo arabinose e manose como observado nos casos dos compostos modelo usados. Os resultados obtidos a partir de amostras do resíduo de café e de café instantâneo sugerem a presença de polissacarídeos híbridos nestas amostras de café processado, corroborando a ocorrência de transglicosilação durante o processo de torra. Além disso, o estudo de misturas contendo diferentes proporções de cada oligossacarídeo modelo, mimetizando regiões do grão de café com composição distinta em polissacarídeos, sujeitos a diferentes períodos de tratamento térmico, permitiu inferir que diferentes estruturas híbridas e não híbridas podem ser formadas a partir das arabinogalactanas e galactomananas, dependendo da sua distribuição nas paredes celulares do grão e das condições de torra. Estes resultados podem explicar a heterogeneidade de estruturas de melanoidinas formadas durante a torra do café. Os resultados obtidos a partir de misturas modelo contendo um oligossacarídeo (Ara3 ou Man3) e 5-CQA sujeitas a tratamento térmico a seco, assim como de amostras provenientes do resíduo de café, mostraram a formação de compostos híbridos compostos por moléculas de CQA ligadas covalentemente a um número variável de resíduos de açúcar. Além disso, os resultados obtidos a partir da mistura contendo Man3 e 5-CQA mostraram que o CQA atua como catalisador das reações de transglicosilação. Por outro lado, nas misturas modelo contendo um péptido, mesmo contendo também 5-CQA e sujeitas ao mesmo tratamento, observou-se uma diminuição na extensão das reações transglicosilação. Este resultado pode explicar a baixa extensão das reações de transglicosilação não enzimáticas durante a torra nas regiões do grão de café mais ricas em proteínas, apesar dos polissacarídeos serem os componentes maioritários dos grãos de café. A diminuição das reações de transglicosilação na presença de péptidos/proteínas pode dever-se ao facto de os resíduos de açúcares redutores reagirem preferencialmente com os grupos amina de péptidos/proteínas por reação de Maillard, diminuindo o número de resíduos de açúcares redutores disponíveis para as reações de transglicosilação. Além dos compostos já descritos, uma diversidade de outros compostos foram formados a partir dos sistemas modelo, nomeadamente derivados de desidratação formados durante o tratamento térmico a seco. Em conclusão, a tipificação das modificações estruturais promovidas pela torra nos polissacarídeos do café abre o caminho para a compreensão dos mecanismos de formação das melanoidinas e da relação estrutura-atividade destes compostos.
Polysaccharides are the major components of green and roasted coffee beans, and coffee brew. The most abundant ones are galactomannans, followed by arabinogalactans. During the roasting process, galactomannans and arabinogalactans undergo structural modifications that are far to be completely elucidated due to their diversity and complexity of the compounds formed. During the roasting process, galactomannans and arabinogalactans react with proteins, chlorogenic acids, and sucrose, originating high molecular weight brown compounds containing nitrogen, known as melanoidins. Several biological activities and beneficial health effects have been attributed to coffee melanoidins. However, their exact structures and the mechanisms involved in their formation remain unknown, as well as the structure-biological activity relationship. The use of model systems and mass spectrometry analysis allow to obtain an overall view and, simultaneously, detailed, of the structural modifications in coffee polysaccharides promoted by roasting, contributing to the elucidation of the structures and formation mechanisms of melanoidins. Based on this thesis, oligosaccharides structurally related to the backbone of galactomannans, (β1→4)-D-mannotriose, and the side chains of arabinogalactans, (α1→5)-Larabinotriose, alone or in mixtures with 5-O-caffeoylquinic acid, the most abundant chlorogenic acid in green coffee beans, and dipeptides composed by tyrosine and leucine, used as models of proteins, were submitted to dry thermal treatments, mimicking the coffee roasting process. The oxidation induced by hydroxyl radicals (HO•) was also studied, since these radicals seem to be involved in the modification of the polysaccharides during roasting. The identification of the structural modifications induced by thermal and oxidative treatment of the model compounds was performed mostly by mass spectrometry-based analytical strategies, but also using liquid chromatography. Gas chromatography was used in the analysis of neutral sugars and glycosidic linkages. To validate the conclusions achieved with the model compounds, coffee polysaccharide samples obtained from spent coffee grounds and instant coffee were also analysed. The results obtained from the model oligosaccharides when submitted to thermal treatment (dry) or oxidation induced by HO• (in solution) indicate the occurrence of depolymerization, which is in line with previous studies reporting the depolymerization of coffee galactomannans and arabinogalactans during roasting. Compounds resulting from sugar ring cleavage were also formed during thermal treatment and oxidative treatment of Ara3. On the other hand, the dry thermal treatment of the model oligosaccharides (alone or when mixed) promoted the formation of oligosaccharides with a higher degree of polymerization, and also polysaccharides with new type of glycosidic linkages, evidencing the occurrence of polymerization via non-enzymatic transglycosylation reactions induced by dry thermal treatment. The transglycosylation reactions induced by dry thermal treatment can occur between sugar residues from the same origin, but also of different origins, with formation of hybrid structures, containing arabinose and mannose in the case of the model compounds used. The results obtained from spent coffee grounds and instant coffee samples suggest the presence of hybrid polysaccharides in these processed coffee samples, corroborating the occurrence of transglycosylation during the roasting process. Furthermore, the study of mixtures containing different proportions of each model oligosaccharide, mimicking coffee bean regions with distinct polysaccharide composition, subjected to different periods of thermal treatment, allowed to infer that different hybrid and non-hybrid structures may be formed from arabinogalactans and galactomannans, depending on their distribution in the bean cell walls and on roasting conditions. These results may explain the heterogeneity of melanoidins structures formed during coffee roasting. The results obtained from model mixtures containing an oligosaccharide (Ara3 or Man3) and 5-CQA and subjected to dry thermal treatment, as well as samples derived from spent coffee grounds, showed the formation of hybrid compounds composed by CQA molecules covalently linked to a variable number of sugar residues. Moreover, the results obtained from the mixture containing Man3 and 5-CQA showed that CQA acts as catalyst of transglycosylation reactions. On the other hand, in the model mixtures containing a peptide, even if containing 5-CQA and subjected to the same treatment, it was observed a decrease in the extent of transglycosylation reactions. This outcome can explain the low extent of non-enzymatic transglycosylation reactions during roasting in coffee bean regions enriched in proteins, although polysaccharides are the major components of the coffee beans. The decrease of transglycosylation reactions in the presence of peptides/proteins can be related with the preferential reactivity of reducing residues with the amino groups of peptides/proteins by Maillard reaction, decreasing the number of reducing residues available to be directly involved in the transglycosylation reactions. In addition to the compounds already described, a diversity of other compounds were formed from model systems, namely dehydrated derivatives formed during dry thermal treatment. In conclusion, the identification of the structural modifications in coffee polysaccharides promoted by roasting pave the way to the understanding of the mechanisms of formation of melanoidins and structure-activity relationship of these compounds.
38
LU, I.-HUNG, and 呂宜鴻. "China’s banking sector is taken as the object of analysis,and the westward strategies of Taiwan-invested banks." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/81260947391885421516.
Full textAbstract:
碩士國立中央大學
產業經濟研究所碩士在職專班
100
Through U.S. subprime lending crisis in 2007, Financial Tsunami in 2008, European debt crisis in 2010 and downgraded U.S. debt rating in 2011, many of the big banks with deep degree of internationalization in world suffered badly. Facing such a market dilemma full of high-degree uncertainty, how China’s banks successfully to carry out innovation and reformation, taking this opportunity to raise in the international financial industry by such favorable situation has become the issue many people very concerned about. In addition, how Taiwan’s banking sector, in this time, to take the original edge to select a favorable strategic position, and further successfully to go westward the mainland China and to deploy the world in order to prepare for the future planning, also is the subject of Taiwan''s banking sector must face up to at this stage. Since the historical development of China’s banking sector is complete and its financial supervisory system becomes more perfect, its openness to Taiwan and foreign investment is increasingly. However, China’s financial reform still continues, among which include liberalization of exchange rate and interest rate, strengthening various financial examinations, liberalizing the scale of financial market, cultivating a new generation of financial professionals, and improving a variety of efficiency are in urgent need of legislation and actual implementation. This thesis, by means of SCP (Structure—Conduct—Performance) system of industrial organization theory, analyzes the industrial structure, how the structure to is influence market conduct, and how the market conduct to decide performance. In the thesis, China’s banking sector is taken as the object of analysis. It is learned that the current situation of China’s banking market is under a market structure of lose oligopoly. Such a market structure will render different directions for Chinese-founded banks, foreign-founded banks and Taiwan-invested banks in future layout in China. In this thesis, it by means of case study regarding current strategies and operation modes of China-founded, foreign-founded and Taiwan-invested banks, incisively analyzes the pros and cons of the current operation and improved ways. Finally, it raises concrete suggestions according to research results, hoping to have a reference value for sustainable development of China’s banking sector, the business layout of foreign-founded banks in Mainland China, and the westward strategies of Taiwan-invested banks.
39
Whyte, Barbara M. "Abortion: what is the good? : developing a deeper understanding of abortion : an analysis with Bernard Lonergan's transcendental method as a creative framework." Thesis, 2008. http://spectrum.library.concordia.ca/976008/1/MR42484.pdf.
Full textAbstract:
This thesis attempts to dismantle the world of meaning which limits the understanding of abortion to only two perspectives: pro-life and pro-choice, and to begin a tentative reconstruction framed on Bernard Lonergan's transcendental method. His method, founded on the concrete subject seeking the good offers a creative framework which validates women's abortion decision-making and acting, as an important source of moral data. The transcendental method consists of the four operations of consciousness: experience, understanding, judging and deciding which operate within each individual. The thesis consists of four chapters each focusing on one of the operations in relation to abortion. I use Daniel Maguire's eight "reality revealing" questions and Lonergan's notions of horizon and social structures in order to reach a deeper understanding of voluntary pregnancy interruption. There are several social structures which require abortion as act of meaning if they are to function effectively. An analysis of the "good" of abortion consists of Lonergan's explanation of the human good; its components, the scale of values, and the three levels of the good. In the conclusion concrete actions are suggested as the result of my tentative reconstruction of a world of meaning in which social and cultural values (the good) are incarnated by individual women voluntarily ending their pregnancy. The question is addressed: Does abortion promote human progress or decline as defined by Lonergan?
40
Dlamini, Bonisile Sisana Faith. "“Disability isn’t contagious, ignorance is”: a critical analysis of the socio-cultural construction of disability in rural Swaziland as portrayed in mainstream media." Thesis, 2020. https://hdl.handle.net/10539/30717.
Full textAbstract:
Minor dissertation submitted in fulfilment of the requirements of the degree of Masters in Critical Diversity Studies, Wits Centre for Diversity Studies, University of the Witwatersrand, 2020Disability happens to be one of the stigmatized discourses in rural Swaziland where myths and superstitions on just about any discourse abound (SINTEF, 2011). My research coincided with the 2018 national elections in Swaziland which is generally a period that is often marked by an alarming rate of ritual murders of people with disabilities. At the heart of ritual murders are ludicrous cultural and social constructions about people with disabilities. Socio-cultural constructions about people with disabilities tend to reinforce and reproduce existing stigma and social inequalities prevalent in rural communities and seldom are these cultural constructions publicly let alone privately challenged, dispelled or interrogated despite their harm. The media (print) being one of the key knowledge producers in Swaziland has often reproduced ableistic notions about people with disabilities thus reinforcing ableism and disability oppression. Entman and Paletz (1980, p. 154) assert that “however unsubstantial or fanciful, the media’s depiction of reality influence the way people think and act politically, the messages affect power”. I therefore opted for this research because disability is amongst the most unpopular, less understood/misunderstood and least researched discourses in Swaziland which is evident in the little, scarce and scanty available resources on disability research. It is also still a less talked about taboo discourse or rather spoken about in hush tones due to misperceptions about it being ‘dirty-linen that ought to be swept under the straw-mat’. Personally, being a rural resident, I have also been indirectly affected by disability through kinship relations whereby I have observed how everyday taken-for-granted language and clichés have propagated and reinforced ableism and disability oppression as is invisible naturalized and legitimated at the expense of people with disabilities. The research also centres on rural communities because that is where about 86% of people with disabilities reside in Swaziland (MoHSW, 2000). Rural communities are generally characterized by a higher level of illiteracy and limited access to knowledge hence myths, misconceptions and superstitions easily breed and are perceived as ‘gospel’ truth (Dlamini, 2017). Socio-cultural constructions become powerful influences that often ‘spread like gangrene’ but when timeously ‘nipped in the bud’ significantly prevent or undo harm on those to whom they are directed or coined which is often marginalized minority groups. It is against this background then that in this research I critically identify and analyse the socio-cultural constructions of people with disabilities as portrayed in mainstream media. This work is divided into five (5) Chapters namely; Chapter 1 contains the Introduction, Research problem, Rationale and Objectives of the study, Chapter 2 is the Literature Review, Chapter 3 is about the Methodology and Theoretical Framework, Chapter 4 is the Data Analysis and lastly Chapter 5 is the Summary Conclusion and the Bibliography. About 50 articles have been gathered as data
CK2021
41
賴世崇. "A study of Steam as the Activator Gas which is used in a Continuous Production Process of Carbon fabric adsorbent and its properties analysis." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/58830978890383340341.
Full textAbstract:
碩士國立臺灣科技大學
纖維及高分子工程技術研究所
85
This research is about the possibility of water turning to steam which is used in a continuous production process of Activated Carbon Fabric. This production process use the regenerated cellulose fiber fabric as the raw material, such as ModalTM, Polynosic and Regular Rayon, and it is has been prepared by pretreatment of refractory reagent [Ammonium Sulfate˙(NH4)2SO4] and [Ammonium Phosphate Dibasic˙(NH4)2HPO4] (mixture ratio: 95/5, concentration:40wt.%). This process is used water into high temperature activation equipment become to steam as the activator gas. In our experimental equipment, used ModalTM as the raw material, the production rate, water flow and the highest treatment temperature of the activated process is used as parameters. We hope knowing the possibility about water into the high temperature activation equipment directly. Then we used same method in the high temperature activation equipment is bigger than old one to understand the possibility of industrialization. The activated carbon fabric (ACF) material is used in the gas adsorption field to understand its properties. When we examined the results, it revealed that it is sure in industrialization when water used in the high temperature activation equipment on a continuous production process of ACF will turn to steam as the activator gas. In this method, we can save energy, equipment cost and so on. The other hand, we also get some characteristic which can control the surface pore''s radius and other activator gas cannot acquired. In the gas adsorption field, our ACF have more pore volume''s adsorption amount because the surface pore''s radius is the biggest among any other activator gas products of ACF.
42
Dilig, Ina Gabriele. "Why is Parfois not selling as weel in Germany and Austria as in other countries? A problem-based analysis of the Portuguese accessory brand Parfois in the German and Austrian market." Master's thesis, 2018. http://hdl.handle.net/10362/52475.
Full textAbstract:
The fashion accessories brand Parfois is facing difficulties in the German and Austrian market.
Low traffic and conversion rates in current operations hinder the brand to expand its store
network. This Work Project aims to identify potential issues and local consumer preferences and
derive marketing recommendations to increase future sales and enable a more effective allocation of
the marketing budget. A triangulation methodological approach combined in-store observations and
qualitative in-depth interviews with consumers and employees, identifying low awareness and
ineffective communication, inconvenient locations and a discrepancy between the target and actual
visitors as critical issues. The primary recommendation is to attract and bond the millennial
generation.
43
Nanoo, Ananta. "Is there an association between trimethoprim-sulfamethoxazole use as prophylaxis and multi-drug resistant non-typhoidal salmonella? A secondary data analysis of antibiotic co-resistance surveillance data in South Africa - 2003-2005." Thesis, 2011. http://hdl.handle.net/10539/9134.
Full textAbstract:
MSc (Med), Epidemiology and Biostatistics, Faculty of Health Sciences, University of the WitwatersrandIntroduction Given the increasing prevalence of non-typhoidal salmonella in humans, especially as an opportunistic illness associated with HIV, enhanced surveillance for non-typhoidal salmonella (NTS), including screening for antibiotic resistance, is conducted annually in South Africa. We aimed to determine whether there is an association between trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis and multi-drug resistant NTS infection, to establish whether various factors modify the relationship between TMP-SMX resistance and invasive NTS infection, to examine whether these associations vary by province, and to quantify the resistance rates of NTS to a range of antibiotics. Methods This study was a secondary analysis of enhanced surveillance data on NTS collected between 2003 and 2005. We used descriptive methods to assess the prevalence of NTS by year, province and serotype, and to determine the prevalence of four MDR patterns. Univariate and multivariate regression models were used to investigate the relationships between TMP-SMX prophylaxis and MDR NTS. Univariate logistic regression was used to assess the relationship between invasive NTS and TMP-SMX resistance. Results TMP-SMX prophylaxis is associated with the ACKSSuT pattern (OR 1.91, 95% CI 1.14 – 3.19, p=0.0080) and the AKSSuT MDR pattern (OR 2.00, 95% CI 1.26 – 3.15, p=0.0015). Being on TMP-SMX prophylaxis is associated with an increased odds of having at least one of the four MDR patterns investigated (OR 1.43, 95% CI 1.00 – 2.04, p=0.0388). We also found high rates of resistance to all antibiotics tested except for ciprofloxacin and imipenem. The highest resistance rate was observed for sulfamethoxazole (>75.85%). S. enterica Isangi isolates showed the highest levels of resistance, with 94.43% having at least one MDR pattern. Other factors significantly associated with MDR NTS were ESBL production, prior treatment with antibiotics, HIV status and resistance to TMP-SMX. Discussion and conclusions Isolates from patients on TMP-SMX prophylaxis were associated with an increased odds of having the ACKSSuT and AKSSuT MDR patterns, not taking into account other explanatory factors. These associations did not remain significant when possible confounders were taken into account. Despite the threat of increased multi-drug resistance, TMP-SMX prophylaxis remains important in certain clinical settings.
44
Letang, Samuel. "The spirituality of ‘seeing him as he is’ according to 1 John 3:2." Thesis, 2017. http://hdl.handle.net/10500/25943.
Full textAbstract:
Includes bibliographical references (leaves 254-281)Using a text-immanent multi-dimensional methodology that combines impulses from both synchronic and diachronic reading of a text, this study focuses on understanding the spirituality embedded in ‘seeing him as he is’ in 1 John 3:2. Discourse analysis has provided the structure of the entire research by identifying the different semantic networks that enhance better understanding and dynamic interaction between text and reader.it has also helped in determining the argument and rhetoric of the Elder, assisting in constructing the bigger picture by means of semantic networks that create coherent mind maps and also relating what has been read with what is still to be read. The environs of the pericope under investigation have been used as a backdrop in order to arrive at an understanding of this envisaged eschatological phenomenon. These environs include the window provided by Judaism through the Old Testament, Hellenistic and Palestinian Judaism, extra-biblical literature, the Graeco-Roman world, mystery religions, philosophies, and the New Testament. These environs have pointed to the use of intermediaries in the visio-Dei. While ‘seeing him as he is’ in 1 John 3:2 involves both the Father and the Son, this eschatological expectation is weaved into a matrix of discourse that the Elder used to cushion the adherents in view of the pending apostasy. The adherents’ status as ‘children of God’ is the axis from which the Elder builds his entire discourse. They will experience love (1 Jn 4:16), his purity (1 Jn 3:3), his righteousness (1 Jn 2:1), his truth (1 Jn 5:20), and his glory (Jn 17:24). Although the adherents were already experiencing all these, it would be experienced completely after the Parousia, when they ‘see him as he is’. This study contributes towards a Johannine understanding of perceiving the divine, and reveals the climactic involvement of the Son in both the past and future perceptions including ‘seeing him as he is’ in 1 John 3:2. This study has identified the object of the Visio-Dei as Christ. It is He through whom believers will see the Father.
Christian Spirituality, Church History and Missiology
D. Phil. (Christian Spirituality)
45
PAUKEJE, Josef. "Funkce polovětných vazeb ve španělském textu a jejich ekvivalenty v češtině." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-80497.
Full textAbstract:
Tato diplomová práce je rozdělena na teoretickou a praktickou část a zabývá se výskytem polovětných konstrukcí tvořených některým z neosobních slovesných tvarů ve španělském jazyce a volbou jejich ekvivalentů při překladu do češtiny. Cílem této práce je poskytnout přehled vlastností, zvláštností a dalších poznatků o polovětných konstrukcích ze španělsky a česky psaných zdrojů. Široké spektrum gramatik, publikací a skript, včetně dvoujazyčného elektronického korpusu literárních děl, přináší nejen velké množství informací o těchto konstrukcích, ale také rozbor volených jazykových prostředků při překladu z jednoho jazyka do druhého a vyhodnocení získaných údajů.
46
Franco, Cátia Madalena da Silva. "Relatório de estágio em edição no serviço editorial do município da Póvoa do Varzim." Master's thesis, 2018. http://hdl.handle.net/10773/24139.
Full textAbstract:
presente relatório pretende apresentar o trabalho realizado no estágio curricular em edição, realizado no Serviço Editorial do Município da Póvoa de Varzim e inserido no plano de estudos do mestrado em Estudos Editoriais, com data de início em novembro de 2017 e data de conclusão em abril de 2018.
O trabalho aqui relatado tem como intuito demonstrar o papel desempenhado enquanto assistente editorial e tecer considerações e reflexões críticas. Para o efeito, apresento os vários projetos editoriais nos quais estive envolvida e analiso diferentes aspetos no desenvolvimento desses projetos.
Dentro da gestão editorial vários temas poderiam ser alvo de análise, no entanto, o principal eixo deste trabalho prende-se com a questão do planeamento e da gestão do tempo. Considerado um fator crítico da gestão editorial, procuramos, ao longo da redação deste relatório, demonstrar quais as razões, os responsáveis e as principais ilações a retirar desta reflexãoMestrado em Estudos Editoriais
47
VRZALOVÁ, Monika. "Role sestry ve screeningu deprese u seniorů." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-260905.
Full textAbstract:
The diploma thesis deals with problems of depression in older people. Mainly the work is focused on identifying and analyzing the role of nurses in screening for depression in older people in primary care, acute care, long-term care and home care. This thesis was focused on theoretical direction and was used the method of design and demonstration. In this thesis was set one main goals with five research questions. The main goal was to identify and analyze the role of nurses in screening for depression in the elderly. RQ 1: What is the role of the nurse in screening for depression in the elderly? RQ 2: What is the role of the nurse in the primary care in screening for depression in the elderly? RQ 3: What is the role of the nurse in screening for depression in hospitalized patients in acute care? RQ 4: What is the role of the nurse in screening for depression in seniors in long-term and home care? RQ 5: What rating scales and methods are used in screening for depression in the elderly? The thesis introduce the concept of depression. The following are specified the causes of and the important factors that affect depression in the elderly. It also deals the differences in the clinical symptomatology of depression in old age. It explains possibilities and various barriers in the diagnosis of depression. Another chapter introduces complete geriatric examination, diagnostic classification systems, possible screening methods and scales for detection of depression in the elderly population. It also deals methods of pharmacological and non-pharmacological treatment and its possible complications associated with older age. By reason of increased suicide rate caused by depressive disorder the issue of suicidal behavior in the elderly is introduced. The next chapter deals with the nursing process, which is used by nurses in practice. It consists of the evaluation of the patient's health condition, making nursing diagnosis, creating nursing plan and subsequent implementation and evaluation. The nursing process is also needy for providing quality care. The nursing process in the stage of nursing diagnosis, introduces possible nursing diagnosis for a patient suffering from depression, which are based on the latest classification. Finally is described the role of nurses in screening for depression in the elderly in different health facilities and their contribution to the timely evaluation of depression in the elderly. This chapter introduces the role of nurses, nursing screening and collaboration with a physician. The role of nurses in screening for depression in different medical facilities is based on the first phase of the nursing process of assessment. On the basis of objective and subjective information, the nurse will assess the overall health and mental condition of the patient. Primarily, it was investigated what is the role of the nurse in screening for depression. On the basis of content analysis and synthesis it was necessary to used and processed domestic and foreign literature. A number of relevant sources are the results of various studies and Meta-analyzes, mostly from abroad, but also from the Czech Republic. The thesis can serve as a basis for nurses. The result of this thesis is to create e-learning material available for students in the Faculty of Health and Social Sciences of South Bohemia in Ceske Budejovice in the tutorial called Moodle.
48
Benda, Marek. "Aféra Spiegel z roku 1962 a krize kolem České televize na přelomu let 2000/2001 pohledem vybraných konceptů demokratické konsolidace." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-351214.
Full textAbstract:
This master thesis deals with the affair Spiegel from 1962 and the Czech Television-Crisis from the turn 2000 and 2001. Both cases are compared by the conceptual approach of democratic consolidation from the Juan Linz's and Alfred Stepan's work The Problems of Democratic Transition and Consolidation (Baltimore, 1996). The analysis aims to find out whether German Federal Republic in 1962 and the Czech Republic on the start of the third millennium fulfilled the first three Linz's and Stepan's criteria of a consolidated democracy. The theoretical chapter highlights some of alternative approaches and discussions about democratic consolidation as an analytical tool in comparative politics.
49
CHIANG-TA-CHENG and 江大成. "The study mainly investigated the table tennis strategy of Taiwanese high school table tennis players by three stage skill analysis. The study analysed players who are from the quarter final in the 2014 National High School Athletic Games(all about Fu Cheng Senior High School players). Games were recorded by video and record those players’ gripping mode from preliminaries to the final game. The gripped mode, three stage skill, and strategy were recorded by 3 A-level coaches. By this way, we can analse high school students’ skill in actual situation. Moreover, we can review the advantage and disadvantage for future training, and enhance their level of skill.The scoring rates of Three-Part Skill are as follow:No.1234 player 48.9％、39.1％、12％, No.1235 player 40.6％、28.1％、31.3％,and No.1240 player 33.1％、35％、32％. The usage rates of Three-Part Skill are as follow:No.1234 player 42.6％、43.3％、14.1％, No.1235 player 38.4％、33.2％、28.2％,and No.1240 player 28.2％、35.1％、36.6％.The overall average of usage rate showed that Three-Part Skill is used more in the section of attack after serve part and attack on return serve part. Conclusion: The research shows that players of Kaohsiung Municipal Fu Cheng Senior High School mainly use quick attack combining top spin and top spin combining quick attack. If they could participate more national events,and train themselves to strengthen their advantages and improve shortcomings. Someday, they can greatly enhance their personal achievement." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/94996991702015980304.
Full textAbstract:
碩士國立臺東大學
體育教學碩士在職專班
104
The study mainly investigated the table tennis strategy of Taiwanese high school table tennis players by three stage skill analysis. The study analysed players who are from the quarter final in the 2014 National High School Athletic Games(all about Fu Cheng Senior High School players). Games were recorded by video and record those players’ gripping mode from preliminaries to the final game. The gripped mode, three stage skill, and strategy were recorded by 3 A-level coaches. By this way, we can analse high school students’ skill in actual situation. Moreover, we can review the advantage and disadvantage for future training, and enhance their level of skill. The scoring rates of Three-Part Skill are as follow:No.1234 player 48.9％、39.1％、12％, No.1235 player 40.6％、28.1％、31.3％,and No.1240 player 33.1％、35％、32％. The usage rates of Three-Part Skill are as follow:No.1234 player 42.6％、43.3％、14.1％, No.1235 player 38.4％、33.2％、28.2％,and No.1240 player 28.2％、35.1％、36.6％.The overall average of usage rate showed that Three-Part Skill is used more in the section of attack after serve part and attack on return serve part. Conclusion: The research shows that players of Kaohsiung Municipal Fu Cheng Senior High School mainly use quick attack combining top spin and top spin combining quick attack. If they could participate more national events,and train themselves to strengthen their advantages and improve shortcomings. Someday, they can greatly enhance their personal achievement.