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Journal articles on the topic "Asan Signature"
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Lee, Keun-Wook, Young Suk Park, Joong Bae Ahn та ін. "332 Novel TGF-β signatures in metastatic colorectal cancer patients treated with vactosertib in combination with pembrolizumab". Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A358. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0332.
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BackgroundDual inhibition of transforming growth factor beta (TGF-β) signaling and PD-1 is a promising strategy to reverse immunosuppressive tumor microenvironment and poor responses to immunotherapy. Based on preliminary clinical data with vactosertib, a highly selective and potent inhibitor of TGF-β receptor type 1, in combination with pembrolizumab, this study aimed to explore a biomarker with predictive value for this regimen in metastatic microsatellite stable (MSS) colorectal cancer (CRC).MethodsTumor biopsy samples were obtained from 24 CRC patients at baseline and cycle 2 in the ongoing MP-VAC-204 study and analyzed by RNAseq and DNAseq. Consensus molecular subtype (CMS), TGF-β responsive gene signatures, IFN-γ signatures, and tumor mutation burden (TMB) were analyzed. Clinically benefited patients were defined by those who achieved objective response assessed by RECIST v1.1/iRECIST or progression free survival more than 24 weeks. Vactosertib responsive gene signature (VRGS) that showed significantly different expression among previously identified TGF-β responsive gene signature and IFN-γ signature in responders than in non-responders was identified and VRGS score was calculated by a mean value of VRGS filtered-in gene expressions divided by 6 house-keeping gene expressions.ResultsAs of July 1, 2020, of the total evaluable 24 patients, 71% were CMS4 subtype and 33% were with high TMB (≥10 mut/Mb). Clinical benefit rate was 33.3% including 3 PR and 1 iPR patients. No significant associations in response rate were observed with CMS subtypes or TMB status. VRGS score was significantly enriched in responders than in non-responders (P value = 0.006; AUC = 0.836). A preliminary cut-off value of 2.179 resulted in 94% specificity and 75% sensitivity with 85.7% patients correctly classifying as a responder. After treatment of vactosertib plus pembrolizumab, TGF-β-related VRGS was significantly decreased and the extent of decrease was greater in responders, compared to non-responders.Ethics ApprovalThe study was approved by Ethics Board of Asan Medical Center, Yonsei University College of Medicine, Samsung Medical Center, and Seoul National University Bundang Hospital with approval number 2018-1215, 4-2018-0728, SMC 2018-07-146-006, and B-1808/487-003, respectively.ConclusionsDevelopment of VRGS as a predictive biomarker for this combination treatment with vactosertib and pembrolizumab is ongoing and its potential clinical utility for patient selection will be explored.Trial RegistrationNCT03724851
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El Fekih, Rania, James Hurley, Vasisht Tadigotla, et al. "Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection." Journal of the American Society of Nephrology 32, no. 4 (2021): 994–1004. http://dx.doi.org/10.1681/asn.2020060850.
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BackgroundDeveloping a noninvasive clinical test to accurately diagnose kidney allograft rejection is critical to improve allograft outcomes. Urinary exosomes, tiny vesicles released into the urine that carry parent cells’ proteins and nucleic acids, reflect the biologic function of the parent cells within the kidney, including immune cells. Their stability in urine makes them a potentially powerful tool for liquid biopsy and a noninvasive diagnostic biomarker for kidney-transplant rejection.MethodsUsing 192 of 220 urine samples with matched biopsy samples from 175 patients who underwent a clinically indicated kidney-transplant biopsy, we isolated urinary exosomal mRNAs and developed rejection signatures on the basis of differential gene expression. We used crossvalidation to assess the performance of the signatures on multiple data subsets.ResultsAn exosomal mRNA signature discriminated between biopsy samples from patients with all-cause rejection and those with no rejection, yielding an area under the curve (AUC) of 0.93 (95% CI, 0.87 to 0.98), which is significantly better than the current standard of care (increase in eGFR AUC of 0.57; 95% CI, 0.49 to 0.65). The exosome-based signature’s negative predictive value was 93.3% and its positive predictive value was 86.2%. Using the same approach, we identified an additional gene signature that discriminated patients with T cell–mediated rejection from those with antibody-mediated rejection (with an AUC of 0.87; 95% CI, 0.76 to 0.97). This signature’s negative predictive value was 90.6% and its positive predictive value was 77.8%.ConclusionsOur findings show that mRNA signatures derived from urinary exosomes represent a powerful and noninvasive tool to screen for kidney allograft rejection. This finding has the potential to assist clinicians in therapeutic decision making.
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Tran, Ivy, Alejandro Vargas, Reid Wilkins, et al. "Abstract 6689: Whole genome cell-free tumor DNA mutational signatures from blood for early detection of recurrence of low stage lung adenocarcinoma." Cancer Research 83, no. 7_Supplement (2023): 6689. http://dx.doi.org/10.1158/1538-7445.am2023-6689.
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Abstract Introduction: Lung cancer remains the leading cause of cancer-related deaths. Surgery is the best option for early lung cancer, and the role of adjuvant therapy remains controversial. Liquid biopsy offers a noninvasive approach to monitor cancer burden. Targeted sequencing of circulating cell free tumor DNA (ctDNA) in blood has shown success for diagnosis; however, low tumor burden and dynamic evolution of low stage disease is challenging for targeted panels. Thus, we hypothesized that a whole genome sequencing (WGS)-derived patient specific mutational signature from a matched tumor-normal WGS can provide sensitive and specific approach to detect mutations and copy numbers in ctDNA for monitoring of lung adenocarcinoma patients. Methods: We successfully profiled 50 Stage 1 or 2 lung adenocarcinomas. ctDNA was extracted from 1-2 mL of plasma, tumor DNA was extracted from pathology tissue and normal germline DNA from the white blood cells. WGS using was performed on matched tumor and normal DNA, and ctDNA extracted from plasma. WGS coverage was 40x for matched tumor-normal and 20x for ctDNA. We derived a personalized mutational pattern for each tumor and used an AI-based error suppression model for quantification and ultra-sensitive detection of ctDNA in plasma samples. A patient-specific personalized genome-wide compendium of somatic mutations and copy numbers was established and ctDNA tested at 3 to 18 available time points during the therapy or follow up. A personalized mutational signature for detection ctDNA from WGS was quantified and the ctDNA Tumor Fraction (TF) was compared to the clinical status and time to recurrence. Results: Tumor specific signatures were derived from matched tumor-normal samples with >5% tumor purity and <30% duplications rate. Out of all patients, 33 patients showed no recurrence and 12 recurred. Tumor-specific signatures detected the presence of the tumor signature in plasma with TF as low as 10−5. Based on positive minimal residual disease in plasma, the recurrence prediction sensitivity was 0.75 and specificity 0.82, with positive predictive value of 0.6 and negative predictive value 0.9. WGS ctDNA predicted recurrence with a median lead time of 508 days before clinical/imaging recurrence. In one case we were able to identify the second primary by deconvoluting known and novel ctDNA mutations. ctDNA mutational profiles enabled identification of smoking mutational signature matching clinical history, and APOBEC and ageing signatures as well as tumor mutational burden. Conclusions: Patient-specific WGS tumor signature from plasma derived ctDNA enables specific and ultrasensitive tracking of minimal residual disease in low stage lung adenocarcinoma patients. Molecularly positive status can be used to predict recurrence and identify patients with clinical low stage disease that may benefit from adjuvant therapy. Citation Format: Ivy Tran, Alejandro Vargas, Reid Wilkins, Isabella Pizzillo, Kenneth Tokoro, Danielle Afterman, Tomer Lauterman, Maja Kuzman, Santiago Gonzalez, Dunja Glavas, James Smadbeck, Dillon Maloney, Jurica Levatic, Samuel Phillips, Sunil Deochand, Michael Yahalom, Ryan Ptashkin, Iman Tavassoly, Zohar Donenhirsh, Eric White, Ravi Kandasamy, Ury Alon, Paz Polak, Boris Oklander, Asaf Zviran, Matija Snuderl, Harvey I. Pass. Whole genome cell-free tumor DNA mutational signatures from blood for early detection of recurrence of low stage lung adenocarcinoma. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6689.
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Pratama, Edwin Yoga, and Nabitatus Sa'adah. "Penggunaan Tanda Tangan Elektronik Pada Sertipikat Hak Tanggungan Elektronik." Notarius 16, no. 3 (2022): 1234–50. http://dx.doi.org/10.14710/nts.v16i3.41661.
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AbstractAn digital signature is an electronically generated signature that functions the same as a regular signature on paper documents. Electronic documentscan be categorized as written evidence, legal principle that makes it difficult to developt the use of electronic documents, the document must be viewable, sent and stored in paper form and also digital data is data that is very vulnerable to engineering. The theory of this research is Gustav Radbruch's theory of legal goals, it is necessary to use the principle of the primacy of three basic values that are the objectives of the law, namely: legal justice, legal expediency and legal certainty and the writing method used is normative juridical. The results is that this electronic signature has been registered with the BSSN, therefore the electronic signature issued is guaranteed because BSSN is one of the bodies trusted by the State, UU ITE has recognized that electronic documents and electronic signatures can be used as legal and perfect evidence, the efforts of the national land agency office are that BPN already has two validated applications, namely veryds and PDF writer, BPN also has its own server only registered users can access the data.Keyword: digital signature; document; electronicAbstrakTanda tangan elektronik adalah tanda tangan yang dibuat secara elektronik, bertindak serupa dengan tanda tangan umumnya pada dokumen kertas. Dokumen elektronik bisa dikelompokkan selaku bukti tertulis, prinsip hukum yang mengakibatkan sukarnya pengembangan penggunaan serta dokumen elektronik, dokumen tersebut haruslah bisa dilihat, dikirim serta disimpan kedalam wujud kertas dan juga mengenai data digital merupakan data yang sangat rentan untuk di rekayasa. Teori penelitian ini adalah teori tujuan hukum Gustav Radbruch, perlunya menggunakan asas prioritas dari tiga nilai dasar yang menjadi tujuan hukum, diantaranya: keadilan hukum, kemanfaatan hukum, kepastian hukum serta metode penulisan yang dipergunakan ialah yuridis normatif. Hasil penelitian ini adalah bahwasanya tanda tangan elektronik ini sudah didaftarkan ke BSSN, maka dari itu tanda tangan elektronik yang dikeluarkan sudah terjamin karna BSSN salah satu badan yang dipercaya oleh Negara, UU ITE sudah mengakui bahwa dokumen elektronik serta tanda tangan elektronik mampu dipergunakan selaku alat bukti yang sah dan sempurna, upaya dari kantor badan pertanahan nasional yakni bahwa BPN telah memiliki dua aplikasi tervalidasi yakni veryds dan PDF writer, BPN juga telah memiliki server sendiri hanya pengguna terdaftar saja yang bisa mengakses data.Kata kunci: tanda tangan elektronik; dokumen; elektronik
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MAHER, A., S. KOSSA, M. KADDAH, and M. El-HUSSEINY. "VIBRATION SIGNATURE ANALYSIS OF TURBOJET ENGINES." International Conference on Aerospace Sciences and Aviation Technology 1, CONFERENCE (1985): 1–12. http://dx.doi.org/10.21608/asat.1985.26535.
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Allen, S. L. "VOEvent authentication via XML digital signature." Astronomische Nachrichten 329, no. 3 (2008): 298–300. http://dx.doi.org/10.1002/asna.200710949.
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Setiawan, Yudhi. "Implementasi Asas Kebebasan Berkontrak dan Asas Keseimbangan Terhadap Perjanjian Pembiayaan Kendaraan Bermotor." JATISWARA 31, no. 3 (2017): 341–59. http://dx.doi.org/10.29303/jtsw.v31i3.53.
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This study was conducted to analyze the agreement used in the process of player’s transfer based on the principle of freedom of contract and the obstacles encountered in the implementation of contract manufacturing for professional players. The method used in this study was a empirical normative legal research, by using the statute approach, concept approach and case approach. The results showed that the written contract made between players and the club showed the existence of freedom of the parties in making the contract, in which the parties have made a contract with the evidence of a signature by the parties. As for the obstacles in the process of professional players’ transfer were the factor of age or minors, financial shortages and the number of players injured at the time when the transfer was opened.
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Kamal, A., H. Dahshan, and A. Rohiem. "An Elliptic Curve Threshold Group Signature Scheme." International Conference on Aerospace Sciences and Aviation Technology 15, AEROSPACE SCIENCES (2013): 1–9. http://dx.doi.org/10.21608/asat.2013.22082.
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Fadhil, Andi Muh, Zulkifli Makkawaru, and Almusawir Almusawir. "ANALISIS KEKUATAN HUKUM PEMBACAAN AKTA NOTARIS MELALUI APLIKASI ZOOM." Clavia 22, no. 1 (2024): 15–26. http://dx.doi.org/10.56326/clavia.v22i1.4095.
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Penelitian ini bertujuan untuk mengetahui keabsahan akta notaris yang dibacakan melalui aplikasi zoom dan, kekuatan hukum digital signature melalui aplikasi zoom, Jenis penelitian yang digunakan adalah yuridis empiris yaitu dengan melakukan penelitian terhadap asas-asas hukum, sumber-sumber hukum seta mengacu pada norma-norma hukum yang terdapat dalam peraturan perundang-undangan yang bersifat teoritis ilmiah. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu Penelitian Pustaka dengan dengan membaca referensi hukum, perundang-undangan, serta dokumen-dokumen, dan penelitian lapangan dengan melakukan wawancara secara langsung Notaris-Notaris di Kota Makassar, Sulawesi Selatan. Berdasarkan hasil penelitian dapat disimpulkan bahwa Kekuatan hukum pembacaan akta Notaris melalui aplikasi zoom untuk saat ini belum dapat dilakukan, selain melangar kode etik Notaris karna merugikan pihak penghadap dimana terjadi gradasi akta autentik menjadi akta dibawa tangan, juga tidak mempunyai kekuatan hukum dan, Penggunaan digital signature menggunakan aplikasi zoom adalah sah dan berkekuatan hukum selama memenuhi ketentuan Pasal 11 ayat (1) Undang-Undang Nomor 11 Tahun 2008 tenteng Informasi Dan Transaksi Elektronik jo Pasal 59 ayat (3) Peraturan Pemerintah Republik Indonesia Nomor 71 Tahun 2019 tentang Penyelenggaraan Sistem Dan Transaksi Elektronik, namun terbatas pada penggunaannya, bukan sebagai akta autentik This research is to determine the validity of notarial deeds read via the Zoom application and the legal strength of digital signatures via the Zoom application. The type of research used is empirical juridical, namely by conducting research on legal principles, legal sources and referring to legal norms. contained in legal regulations that are scientific theoretical in nature. The data collection technique used in this research is library research by reading legal references, legislation, and documents, and field research by conducting direct interviews with notaries in Makassar City, South Sulawesi. Based on the results of the research, it can be concluded that the legal force of reading a Notary's deed via the Zoom application is currently not possible, apart from violating the Notary's code of ethics because it is detrimental to the presenting party where there is a gradation of an authentic deed to a hand-carried deed, it also has no legal force and, the use of a digital signature using the zoom application is legal and has legal force as long as it meets the provisions of Article 11 paragraph (1) of Law Number 11 of 2008 concerning Electronic Information and Transactions in conjunction with Article 59 paragraph (3) of the Government Regulation of the Republic of Indonesia Number 71 of 2019 concerning Implementation of Electronic Systems and Transactions, but limited to its use, not as an authentic deed.
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Rehulina, Rehulina. "KEABSAHAN DIGITAL SIGNATURE DALAM PERJANJIAN E-COMMERCE." DOKTRINA: JOURNAL OF LAW 1, no. 1 (2018): 45. http://dx.doi.org/10.31289/doktrina.v1i1.1609.
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<p>Transaksi perdagangan elektronik atau <em>electronic commerce transaction </em>yang biasa disebut dengan <em>e-commerce </em>adalah kegiatan dalam bidang perniagaan yang banyak menggunakan jaringan internet dalam melakukan penawaran dan permintaan.Menurut Mariam Darus Badrulzaman istilah lain yang dipakai untuk <em>e-commerce </em>di antaranya kontrak dagang elektronik, kontrak siber, transaksi dagang elektronik, dan kontrak web.<em>Electronic Commerce transaction </em>adalah transaksi dagang antara penjual dan pembeli untuk menyediakan barang, jasa, atau mengambil alih hak melalui media elektronik dimana para pihak tidak hadir secara fisik dan menggunakan jaringan umum dengan sistem terbuka yaitu internet.Metode penelitian yang digunakan adalah yuridis normatif yang merupakan suatu metode penelitian yang mengacu pada norma-norma hukum yang terdapat dalam peraturan perundang-undangan.Penelitian yuridis normatif yang dilakukan dengan upaya menganalisis permasalahaan dalam penelitian melalui pendekatan asas-asas hukum serta mengacu pada norma-norma hukum yang terdapat dalam peraturan yang erat kaitannya dengan pokok bahasan. Mengutip istilah Ronald Dworkin, penelitian ini juga disebut dengan penelitian doctrinal (<em>doctrinal research</em>), yaitu suatu penelitian yang menganalisis hukum baik yang tertulis di dalam buku (<em>lawas written in the book</em>), maupun yang diputuskan oleh hakim melalui proses pengadilan (<em>law as it is decided by the judge through judicial prcess</em>).Tanda tangan digital harus diterima keabsahannya sebagai tanda tangan dengan alasan sebagai berikut:Tanda tangan digital merupakan tanda tangan yang bisa dibubuhkan oleh seseorang atau beberapa orang yang diberikan kuasa oleh orang lain yang berkehendak untuk diikat secara hukum;Sebuah tanda tangan digital dapat dimasukkan dengan menggunakan peralatan mekanik, sebagaimana tanda tangan tradisional/konvensional;Sebuah tanda tangan digital sangat mungkin bersifat lebih aman atau lebih tidak aman sebagaimana kemungkinan ini juga terjadi pada tanda tangan tradisional/konvensional;Waktu membubuhkan tanda tangan digital, niat sipenandatangan yang menjadi keharusan juga bisa dipenuhi sebagaimana pada tanda tangan tradisional/konvensional.</p>
Dissertations / Theses on the topic "Asan Signature"
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Liu, Yin Miao. "Visually sealed and digitally signed electronic documents : building on Asian tradition." Thesis, Queensland University of Technology, 2004. https://eprints.qut.edu.au/15967/1/Yin-Miao_Liu_Thesis.pdf.
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E-commerce has developed through the use of digital signatures, employing various forms of Public Key Infrastructure (PKI) to ensure the secure usage of digital signatures. Digital signatures are designed to facilitate the functions of traditional seals and handwritten signatures for the purposes of authentication, data integrity, and non-repudiation within the e-commerce environment. Historically, the authenticity of documentation has always been verified by the application of a recognisable visual stimulus to the document; however, the current digital signature regime overlooks the importance of this analogous sense of visualisation. One of the primary problems with existing digital signatures is that a digital signature does not "feel" like, or resemble, a traditional seal to the human observer, as it does not have a personal, recognisable, or aesthetic sense of visualisation. Currently, digital signatures, such as the OpenPGP (Pretty Good Privacy) digital signature, are attached to the end of an electronic document as a stream of printable ASCII characters. (RFC2440) This appears to the average user as a long, incomprehensible string of random characters offering no sense of identity or ownership by simple visual inspection. Additionally, digital signatures change each time they are applied, in contrast to traditional seals that remain consistent personal identifiers associated with individual signatories. The goal of this research is to promote enhancements to existing digital signature schemes in order to bridge the cultural gap between traditional seals and digital signatures. Culturally friendly features integrated into the digital signature have the potential to increase user acceptability of global e-commerce. This research investigates traditional seal cultures within the context of modern digital signatures, identifying the need to develop a new, culturally friendly, visualised digital signature scheme. The principles behind digital signatures are reviewed and the essential roles and responsibilities of a PKI are addressed. A practical analysis of PKI implementation is also essential. Taiwan is selected as the focus of this research since its heritage is deeply rooted in, and strongly adheres to the Chinese seal culture. The Taiwanese government is in the process of adapting the traditional seal certificate system to the electronic digital signature system. Therefore it is pertinent to review the PKI implementation and digital signatures applications in Taiwan in this study. The purpose of this research is to make the intangible digital signature virtually tangible; i.e., to incorporate visualisation into the current digital signature practice. This research defines new private extensions to the X.509 v3 certificate, recommending that conforming visualised digital signature applications should then be developed to generate and/or recognise visual digital certificates in support of the proposed visualised digital signature scheme. The processes of visualised digital signature creation and of verification through the application of the visualised digital certificate are then explained. This is accompanied by a model of system analysis for developers of conforming implementations of this specification. This allows developers the freedom to select appropriate developing tools. An analysis of this research evaluates the quality of integrity, security, interoperability, performance, and flexibility offered by this proposal.Future directions for furthering research development conclude this dissertation.
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Liu, Yin Miao. "Visually sealed and digitally signed electronic documents: Building on Asian tradition." Queensland University of Technology, 2004. http://eprints.qut.edu.au/15967/.
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E-commerce has developed through the use of digital signatures, employing various forms of Public Key Infrastructure (PKI) to ensure the secure usage of digital signatures. Digital signatures are designed to facilitate the functions of traditional seals and handwritten signatures for the purposes of authentication, data integrity, and non-repudiation within the e-commerce environment. Historically, the authenticity of documentation has always been verified by the application of a recognisable visual stimulus to the document; however, the current digital signature regime overlooks the importance of this analogous sense of visualisation. One of the primary problems with existing digital signatures is that a digital signature does not "feel" like, or resemble, a traditional seal to the human observer, as it does not have a personal, recognisable, or aesthetic sense of visualisation. Currently, digital signatures, such as the OpenPGP (Pretty Good Privacy) digital signature, are attached to the end of an electronic document as a stream of printable ASCII characters. (RFC2440) This appears to the average user as a long, incomprehensible string of random characters offering no sense of identity or ownership by simple visual inspection. Additionally, digital signatures change each time they are applied, in contrast to traditional seals that remain consistent personal identifiers associated with individual signatories. The goal of this research is to promote enhancements to existing digital signature schemes in order to bridge the cultural gap between traditional seals and digital signatures. Culturally friendly features integrated into the digital signature have the potential to increase user acceptability of global e-commerce. This research investigates traditional seal cultures within the context of modern digital signatures, identifying the need to develop a new, culturally friendly, visualised digital signature scheme. The principles behind digital signatures are reviewed and the essential roles and responsibilities of a PKI are addressed. A practical analysis of PKI implementation is also essential. Taiwan is selected as the focus of this research since its heritage is deeply rooted in, and strongly adheres to the Chinese seal culture. The Taiwanese government is in the process of adapting the traditional seal certificate system to the electronic digital signature system. Therefore it is pertinent to review the PKI implementation and digital signatures applications in Taiwan in this study. The purpose of this research is to make the intangible digital signature virtually tangible; i.e., to incorporate visualisation into the current digital signature practice. This research defines new private extensions to the X.509 v3 certificate, recommending that conforming visualised digital signature applications should then be developed to generate and/or recognise visual digital certificates in support of the proposed visualised digital signature scheme. The processes of visualised digital signature creation and of verification through the application of the visualised digital certificate are then explained. This is accompanied by a model of system analysis for developers of conforming implementations of this specification. This allows developers the freedom to select appropriate developing tools. An analysis of this research evaluates the quality of integrity, security, interoperability, performance, and flexibility offered by this proposal.Future directions for furthering research development conclude this dissertation.
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Chen, Quan. "Signatures détritiques des changements paléoenvironnementaux du Quaternaire récent dans le bassin nord de la mer de Chine du Sud." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS492/document.
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Le but de cette thèse est de reconstruire l’évolution environnementale de la région nord de la mer de Chine du Sud au cours du Quaternaire récent. L'objectif est d'identifier des traceurs des interactions continent-océan, de la mousson est-asiatique et de la circulation océanique. Pour cela, des analyses des minéralogies argileuse et magnétique, de la composition en éléments majeurs, et la taille des grains ont été effectuées sur les sédiments de carotte MD12-3432 couvrant les derniers 400 ka avec un taux de sédimentation variant entre 4.5 et 24 cm/ka. Nous avons tout d'abord amélioré les calibrations de la composition en éléments majeurs obtenue par XRF core-scanning. En effet, celles-ci ne corrigeaient pas des variations de teneur en eau interstitielle observées la séquence sédimentaire étudiée. Nous avons donc proposé une correction polynomiale quadratique qui convertit maintenant correctement les données XRF core-scanning en concentrations précises d’éléments majeurs. La composition en élément majeurs, les minéralogies argileuse et magnétique, et la granulométrie indiquent que les changements climatiques à basse latitude influencent les diverses fractions terrigènes de différentes manières. Considérant d’abord les éléments majeurs et les argiles, nous observons que les rapports smectite/(illite+chlorite) et K₂O/Al₂O₃ présentent tous deux des cyclicités orbitales. Le rapport K₂O/Al₂O₃ qui reflète la contribution relative des apports de Taiwan par dénudation, augmente pendant les interglaciaires quand la mousson d’été asiatique est forte. Le rapport smectite/(illite+chlorite) présente des cyclicités également liées à l’excentricité et à la précession en phase avec les changements d’insolation de l’hémisphère nord en été. Connaissant les régions sources de ces argiles, nous suggérons que l’apport en smectite est étroitement lié à l'intensité de l’altération chimique et à la dénudation fluvial induite par les fortes précipitations de mousson, tandis que l’apport d’illite/chlorite depuis Taiwan répond principalement à la dénudation. Le rapport smectite/(illite+chlorite) reflète ainsi principalement l'intensité de l’altération chimique contemporaine (rapide) et donc l’intensité de la mousson d'été asiatique. Les résultats obtenus confirment que la mousson d'été asiatique est renforcée pendant les périodes interglaciaires et quand l'insolation d'été boréal est forte. Les propriétés magnétiques sédimentaires offrent des informations complémentaires sur les changements environnementaux passés dans cette région. La fraction magnétique de la carotte MD12-3432 est composée de magnétites, sulfures de fer et hématite. Des augmentations de teneur en hématite et des diminutions de la granulométrie sédimentaire sont observées aux minima de précession. Ces évènements qui ont lieu pendant les périodes arides pourraient illustrer des apports éoliens depuis le nord de la Chine, liés à des changements d'intensité et/ou de route des vents, probablement aussi liés à l’intensification de la mousson d'hiver. Outre les changements climatiques de basse latitude, le climat global et l'activité tectonique influencent aussi les apports terrigènes dans cette région. Les augmentations à long terme de la teneur en pyrrhotite par rapport à la magnétite et à l’hématite, de la teneur de illite/chlorite indiquent une contribution croissante de sédiment fine d'origine Taiwanaise au cours des derniers 400 ka. Ceci est très probablement lié à l’intensification de l'orogenèse taïwanais. A l'échelle glaciaire-interglaciaire, les variations synchrones des compositions argileuse et magnétique, de la taille des grains sédimentaires et magnétiques, et des taux de sédimentation sont attribuées aux changements de niveau marin. En effet, les bas niveaux marins pendant les périodes glaciaires exposent l’immense plateau continental et permettent à la Rivière des Perles de livrer au site du sédiment terrigène en plus grande quantité et plus grossier<br>The aim of this study is to reconstruct late Quaternary environmental changes in the northern South China Sea by applying multi-disciplinary proxies of land-sea interaction, East Asian monsoon, and oceanic circulation. Investigations of clay and magnetic mineralogy, major element composition, and grain size were performed on marine sediment Core MD12-3432 retrieved from the continental slope of the northern South China Sea. The core covers the last 400 ka with a sedimentation rate varying between 4.5 and 24 cm/ka. We examined the accuracy of existing calibration methods on major element composition obtained by XRF core-scanning, because downcore variations in interstitial water content should strongly affect scanned element contents. We proposed a quadratic polynomial correction to account for this effect and implemented it in the calibration methods. Data from Core MD12-3432 show that the improved calibration process now correctly converts XRF core-scanning data into major element concentrations. Our results on high-resolution major element composition, clay and magnetic mineralogy, and grain size data indicate that low-latitude climate changes influence various terrigenous fractions in different ways. In bulk sediment, K₂O/Al₂O₃ ratio mainly reflects the relative contribution of detrital supply from Taiwan, and its variation exhibits eccentricity cycles. The ratio increases during interglacials, showing that strong precipitation and denudation are induced by enhanced East Asian summer monsoon. In clay fractions, smectite/(illite+chlorite) ratio presents both eccentricity and precession periodicities, in phase with the northern hemisphere summer insolation changes and therefore with the East Asian summer monsoon evolution. Based on the knowledge of sediment provenances, these results suggest that high smectite/(illite+chlorite) ratios illustrate contemporaneous chemical weathering intensity in Luzon. It supports the understanding that East Asian summer monsoon is enhanced during interglacial periods and when the boreal summer insolation is strong. Therefore, these two ratios are appropriate sedimentary tracers for East Asian summer monsoon evolution in the South China Sea. The magnetic fraction yields complementary information about environmental changes in the South China Sea. The magnetic mineral assemblage of Core MD12-3432 is mainly composed of magnetite, sulphide, and hematite, and the relative contributions of all these magnetic mineral contents change with time. Variations on precessional band related to the low latitude East Asian monsoon are observed in magnetic properties and grain size values. High magnetic inputs with high hematite proportion, which is part of fine-grain sediment, are observed during the precession minima. These events occurring during arid periods may illustrate enhanced eolian inputs caused by changes in intensity and/or winds pathway of winds, probably related to enhanced winter monsoon. Besides the low-latitude climate changes, global climate and tectonic activity also influence the terrigenous composition at the studied site at different timescales. A long-term increase in pyrrhotite content with respect to magnetite and hematite and in illite/chlorite contents indicates an increasing contribution of fine grained sediments from Taiwan. This is most likely related to the intensification of Taiwanese orogeny over the last 400 ka. On glacial-interglacial scale, coeval increases observed in sedimentation rate, magnetite/pyrrhotite content, kaolinite content, and grain size during glacial periods are attributed to sea-level changes. Low sea-level during glacial periods exposes the vast shelf and allows the Pearl River to deliver more and coarser terrigenous sediments to our site
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Wang, Jen-Fang, and 王仁芳. "Ariane Mnouchkine and the East Asian Signatures in Her Works." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/89570856778731775669.
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碩士<br>國立臺灣大學<br>戲劇研究所<br>102<br>Ariane Mnouchkine, the director of Théâtre du Soleil, has been interested in Oriental theatre performances since the early stage of her directing career from 1960s. Under the influences with “Oriental fever” in French theatrical circles in 18th to 20th century, Mnouchkine followed the tradition to appropriate oriental elements in playwriting, stage design, acting and directing; moreover, she established her own concept of Oriental Theatre. By collective improvisation with members of Théâtre du Soleil, Mnouchline used the form of Oriental Theatre against realistic performances. By doing so, she fulfilled the ideal of creating a new form for western theatre, and conveyed universalism.
Focusing on East Asian culture, which is most relevant to ours, this thesis studies six works of Mnouchkine with East Asian elements: Gengis Khan, L'Age d'or, Richard II, Henry IV：part one, Et soudain, des nuits d'éveil and Tambours sur la digue. Based on these works, it examines how East Asian traditional theatre had inspired Mnouchkine’s works, and what directing methods that she had used to transform the East Asian mise-en-scène and acting techniques.
This study also identifies and criticizes the decontextualization of East Asian elements in Mnouchkine’s works by contrasting her works with traditional East Asian theatres. Meanwhile, I also recognize Mnouchkine’s brilliant contribution in fusing and transforming Oriental theatre elements into a whole new theatre form. Ariane Mnouchkine received divided opinions on her works containing East Asian signatures after touring the world. These differences in opinions then further facilitated dialogue and exchanges between the Eastern and the Western cultures, as well as introspection on both sides.
Books on the topic "Asan Signature"
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Foundation, Asia Pacific Breweries, ed. Signature art prize 2011: Asia Pacific Breweries Foundation. Singapore Art Museum, 2011.
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Museum, Singapore Art, and National Museum of Singapore, eds. Signature Art Prize 2018: Asia Pacific Breweries Foundation. Singapore Art Museum, 2018.
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Lee, Ho-Chul, Andrew P. Killick, and Sukyeon Cho. Southerners, Northerners: A Novel (Signature Books (White Plains, N.Y.).). Eastbridge, 2004.
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African, Asian, and Middle Eastern artists: Signatures and monograms from 1800 : a directory. Scarecrow Press, 2009.
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Chuikov, V. I., and David P. Barrett. Mission to China: Memoirs of a Military Adviser to Chiang Kaishek (Signature Books). Eastbridge, 2003.
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Chuikov, V. I., and David P. Barrett. Mission to China: Memoirs of a Soviet Military Adviser to Chiang Kaishek (Signature Books). Eastbridge, 2003.
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Rampone, William, and Eric Mallin, eds. Global King Lear. Bloomsbury Publishing Plc, 2024. https://doi.org/10.5040/9781350421974.
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Global King Learprovides a kaleidoscopic view of multinational adaptations ofKing Learwith a focus on productions across Asia and Eastern Europe. By approaching Shakespeare’s great tragedy as a global phenomenon its signature themes become context-dependent and culture-specific whilst avoiding simplistic appeals to the play’s universality. International scholars of literature and theatre explore those culturally specific interpretations as new plays, films, and critical contributions on their own terms. As a film in Japan,King Learbecomes a meditation on contemporary eldercare and the question of celebrity; on a stage in Hungary the play emerges as a ferocious invective against domestic abuse; in another performance in Hungary the play considers childhood trauma and a crisis in maternal care; and a pan-Asian Lear emerges out of multiple adaptations on stage and screen in India, Japan, and China. Taken together these readings are dismantled as merely derivative interpretations and cast instead as theatrical and cinematic engines of transformation. Despite the play’s focus on the cultural context of England, this volume highlightsKing Lear’s position as one of the most popular texts for international directors and playwrights to explore their own nations’ troubles and challenges. This collection focuses on the potential forKing Learto be performed, adapted, and understood anew by multiple audiences in a range of mediums and contexts.
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Kingsbury, Benedict, David M. Malone, Paul Mertenskötter, Richard B. Stewart, Thomas Streinz, and Atsushi Sunami, eds. Megaregulation Contested. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198825296.001.0001.
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The Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) of 2018 is the most far-reaching “megaregional” economic agreement in force. Japan, the largest economy among the eleven signatory countries, played a leading role in bringing CPTPP into being and in the decision largely to preserve in its provisions the stamp of the original US involvement before the Trump-era reversal. The Trans-Pacific Partnership (TPP) is the first instance of “megaregulation”: a demanding combination of inter-state economic ordering and national regulatory governance on a highly ambitious substantive and transregional scale. Its text and ambition have influenced other negotiations ranging from the Japan–EU Economic Partnership Agreement (JEEPA) and the US–Mexico–Canada Agreement (USMCA) to the projected Pan-Asian Regional Comprehensive Economic Partnership (RCEP). This book provides an extensive analysis of TPP as a megaregulatory project for channeling and managing new pressures of globalization, and of core critical arguments made against economic megaregulation from standpoints of development, inequality, labor rights, environmental interests, corporate capture, and elite governance. Specialized chapters cover supply chains, digital economy, trade facilitation, intellectual property, currency levels, competition and state-owned enterprises, government procurement, investment, prescriptions for national regulation, and the TPP institutions. Country studies include detailed analyses of TPP-related politics and approaches in Japan, Mexico, Brazil, China, India, Indonesia, and Thailand. Contributors include leading practitioners and scholars in law, economics, and political science. At a time when the World Trade Organization (WTO) and other global-scale institutions are struggling with economic nationalism and geopolitics, and bilateral and regional agreements are pressed by public disagreement and incompatibility with digital and capital and value chain flows, the megaregional ambition of TPP is increasingly important as a precedent requiring the close scrutiny this book presents.
Book chapters on the topic "Asan Signature"
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Davis, Darrell William, and Emilie Yueh-yu Yeh. "Genre/Nation: Cultural Commerce and Signature Narratives." In East Asian Screen Industries. British Film Institute, 2008. http://dx.doi.org/10.1007/978-1-349-92177-5_6.
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Mu, Yi, Fangguo Zhang, and Willy Susilo. "Deniable Partial Proxy Signatures." In Advances in Computer Science - ASIAN 2004. Higher-Level Decision Making. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-30502-6_13.
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Zhang, Jianhong, Hua Chen, Shengnan Gao, and Yixian Yang. "A Special Proxy Signature Scheme with Multi-warrant." In Advances in Computer Science - ASIAN 2009. Information Security and Privacy. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-10622-4_12.
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Major, David J., Richard Baumeister, Alassane Touré, and Suling Zhao. "Methods of Measuring and Characterizing the Effects of Stresses on Leaf and Canopy Signatures." In ASA Special Publications. American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, 2015. http://dx.doi.org/10.2134/asaspecpub66.c8.
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Patil, Rajkumar, Ching-Yu Cheng, Chui Ming Gemmy Cheung, and Tien Yin Wong. "Unique Genetic Signatures in Asian Age-Related Macular Degeneration: An Opportunity for Drug Development." In Essentials in Ophthalmology. Springer Japan, 2017. http://dx.doi.org/10.1007/978-4-431-56511-6_37.
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Hall, Ian. "Prosperity and Connectivity." In Modi and the Reinvention of Indian Foreign Policy. Policy Press, 2019. http://dx.doi.org/10.1332/policypress/9781529204605.003.0006.
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This chapter examines the Modi government’s foreign economic policy, focusing especially on its reform agenda – including signature projects like ‘Make in India’ – and its relations with other South Asian states. It argues that despite Modi’s rhetoric about globalisation, inclusion and connectivity, his government’s economic agenda was conditioned more by inherited Hindu nationalist ideas than by liberal principles. These ideas, the chapter contends, tethered the Modi government to a form of economic nationalism. It explores the limited reforms pursued, and the consequences for India’s economy and its trade and investment relations with other states. Finally, it discusses the Modi government’s evolving attitude to China’s Belt and Road Initiative, which threatened to draw India and other South Asian states further into Beijing’s economic orbit.
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Welch, Anthony, and Gerard Postiglione. "Silk Road South." In China and Europe on the New Silk Road. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198853022.003.0008.
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For something like two millennia, the Silk Road has functioned as a conduit, for ideas as well as trade. China’s rise now presents both challenges and opportunities to countries situated on both the maritime and terrestrial Silk Roads, particularly in higher education. Beginning with Europe’s response to China’s renaissance as a major knowledge system, differential responses within Europe are charted, and student and staff flow treated. Some signs of change are evident, from 2018, particularly in relation to sensitive high-tech areas such as those listed in the signature Made in China 2025 policy. But the Silk Road also points South, hence the remainder of the chapter addresses higher education relations between China and ASEAN, and in particular, Malaysia. The Six Pillars framework is used to outline the major elements of China–ASEAN relations, particularly regarding higher education, including the development of the overseas campus of Xiamen University in Malaysia.
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"A Tale of the Evil Wind." In The Animist Imagination in East Asian Cinema. Amsterdam University Press, 2025. https://doi.org/10.5117/9789048563999_ch05.
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This chapter examines Sweet Bean(Kawase Naomi, 2015), the protagonist of which adopts an animist mode of being characterized by openness to and communication with nonhumans, including the titular ingredient used in her signature confection. The film links this animist capacity to her contraction of Hansen’s disease and the institutional history of leper colonies in Japan. The chapter analyzes how the film engages with haptic visuality and navigates various generic frameworks—from the process genre to melodrama—to portray the protagonist’s animist capacity through culinary production. This emphasis on food preparation and cooking holds ethical and political significance for contemporary Japanese society, particularly in light of the post-Fukushima food security crisis.
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Hrivnyak, Michelle, and Jacqueline T. Eng. "Environmental dynamics and stable isotopic signatures in early Inner Asian Steppe communities." In The Routledge Handbook of the Bioarchaeology of Climate and Environmental Change. Routledge, 2020. http://dx.doi.org/10.4324/9781351030465-30.
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Sirimongkolkitti, A., V. Pisutha-Arnond, and S. Pisutha-Arnond. "Carbon isotopic signature of CO2 in Arthit gas field, Northern Malay basin, the Gulf of Thailand." In Petroleum Geochemistry and Exploration in the Afro-Asian Region. Taylor & Francis, 2007. http://dx.doi.org/10.1201/9780203930649.ch19.
Full textConference papers on the topic "Asan Signature"
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Kumar, G. Manoj, P. Satyanarayana, B. Sridhar, K. Tejo Rohith, G. V. S. Padma Rao, and V. Gokula Krishnan. "Deep Neural Networks based Handwritten Signature Verification using Machine Learning Algorithms." In 2024 Asian Conference on Intelligent Technologies (ACOIT). IEEE, 2024. https://doi.org/10.1109/acoit62457.2024.10939870.
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Reddy, Malireddy Charan Kumar, Katragadda Megha Shyam, Kandlapalli Aravind Sai, and Vishwas Hn. "Defending Authenticity: Real-Time Signature Verification with Deep Learning Models." In 2024 4th Asian Conference on Innovation in Technology (ASIANCON). IEEE, 2024. https://doi.org/10.1109/asiancon62057.2024.10837730.
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Rahmanov, Farhad, Elchin Suleymanov, and Khayala Ibrahimova. "Development of E-State and Innovative Technology in Improving Public Service Quality in Azerbaijan." In International Conference on Eurasian Economies. Eurasian Economists Association, 2020. http://dx.doi.org/10.36880/c12.02358.
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The rapid development of the Internet technologies and the continuous increase in the usage area, increase the service quality and speed by utilizing the internet technologies in some of the public services provided. Most of the public services are now provided as electron in developed countries. The concept of state management through innovation methods, the importance of e-government structure in increasing the speed of the state provided by the state is increasing every day, Azerbaijan is also one of the fastest developing countries as it is an internet infrastructure and its population is highly effective on the internet and other innovative technologies. Particularly, some of the oil revenues coming to the country are spent on modernization of modern technologies. The aim of this study is to examine the effects of innovation and e-government applications in the field of public administration in Azerbaijan over the last decade and its impact on public service quality. Developments in recent years in terms of increasing the quality of public service in Azerbaijan, ASAN service, E Signature, ASAN Signature, Electronic tax system and other innovations in the field of public service have constituted the subject of the research and at the end of the study proposals have been made to increase the efficiency of the system.
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Zhu, Zhifeng, and Paul Leone. "Locate Faulty Components by IR Based Direct Current Injection Method with Analog Signature Analysis." In ISTFA 2021. ASM International, 2021. http://dx.doi.org/10.31399/asm.cp.istfa2021p0029.
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Abstract This article describes a method that combines Analog Signature Analysis (ASA) with IR based Direct Current Injection (IRDCI) for printed circuit board assembly failure analysis. The integration of ASA extends the diagnostic capability of IRDCI from shorted power rails to any measurement location that shows signature differences. It also facilitates the detection of electrical breakdown or degradation without having to remove suspected faulty components from the board.
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Katoh, Kentaroh, Toru Tanabe, Haque Md Zahidul, Kazuteru Namba, and Hideo Ito. "A Delay Measurement Technique Using Signature Registers." In 2009 Asian Test Symposium. IEEE, 2009. http://dx.doi.org/10.1109/ats.2009.54.
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Wilson-Nunn, Daniel, Terry Lyons, Anastasia Papavasiliou, and Hao Ni. "A Path Signature Approach to Online Arabic Handwriting Recognition." In 2018 IEEE 2nd International Workshop on Arabic and Derived Script Analysis and Recognition (ASAR). IEEE, 2018. http://dx.doi.org/10.1109/asar.2018.8480300.
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De Dormale, Guerric, Renaud Ambroise, David Bol, Jean-jacques Quisquater, and Jean-didier Legat. "Low-Cost Elliptic Curve Digital Signature Coprocessor for Smart Cards." In IEEE 17th International Conference on Application-specific Systems, Architectures and Processors (ASAP'06). IEEE, 2006. http://dx.doi.org/10.1109/asap.2006.44.
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Balasubramanian, Sundar, Harold W. Carter, Andrey Bogdanov, Andy Rupp, and Jintai Ding. "Fast multivariate signature generation in hardware: The case of rainbow." In 2008 International Conference on Application-Specific Systems, Architectures and Processors (ASAP). IEEE, 2008. http://dx.doi.org/10.1109/asap.2008.4580149.
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Tamura, Masato, та Makoto Ikeda. "1.68μJ/signature-generation 256-bit ECDSA over GF(p) signature generator for IoT devices". У 2016 IEEE Asian Solid-State Circuits Conference (A-SSCC). IEEE, 2016. http://dx.doi.org/10.1109/asscc.2016.7844205.
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Marchiori, Dúnia, Alexandre A. Giron, João Pedro A. do Nascimento, and Ricardo Custódio. "Timing Analysis of Algorithm Substitution Attacks in a Post-Quantum TLS Protocol." In Simpósio Brasileiro de Segurança da Informação e de Sistemas Computacionais. Sociedade Brasileira de Computação - SBC, 2021. http://dx.doi.org/10.5753/sbseg.2021.17311.
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Snowden's revelations about mass surveillance brought to public attention devastating attacks on cryptographic algorithm implementations. One of the most prominent subsets of these attacks is called Algorithm Substitution Attacks (ASA), where a subverted implementation leaks sensitive information. Recently, it has been proposed to modify TLS implementations to use Post-Quantum Cryptography (PQC). In this paper, we propose and analyze ASA in two PQC schemes that can be used in TLS. We attacked the Kyber Key Encapsulation Mechanism (KEM) and Falcon Signature and successfully deployed them in a TLS implementation. Results show that timing analysis can distinguish our Falcon subversion, but it is not enough to detect our attacks deployed in TLS.