Relevant bibliographies by topics / Asan Signature / Journal articles
To see the other types of publications on this topic, follow the link: Asan Signature.

Journal articles on the topic 'Asan Signature'

Author: Grafiati
Published: 5 June 2025
Last updated: 24 June 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Asan Signature.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Lee, Keun-Wook, Young Suk Park, Joong Bae Ahn та ін. "332 Novel TGF-β signatures in metastatic colorectal cancer patients treated with vactosertib in combination with pembrolizumab". Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A358. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0332.

Full text
Abstract:
BackgroundDual inhibition of transforming growth factor beta (TGF-β) signaling and PD-1 is a promising strategy to reverse immunosuppressive tumor microenvironment and poor responses to immunotherapy. Based on preliminary clinical data with vactosertib, a highly selective and potent inhibitor of TGF-β receptor type 1, in combination with pembrolizumab, this study aimed to explore a biomarker with predictive value for this regimen in metastatic microsatellite stable (MSS) colorectal cancer (CRC).MethodsTumor biopsy samples were obtained from 24 CRC patients at baseline and cycle 2 in the ongoing MP-VAC-204 study and analyzed by RNAseq and DNAseq. Consensus molecular subtype (CMS), TGF-β responsive gene signatures, IFN-γ signatures, and tumor mutation burden (TMB) were analyzed. Clinically benefited patients were defined by those who achieved objective response assessed by RECIST v1.1/iRECIST or progression free survival more than 24 weeks. Vactosertib responsive gene signature (VRGS) that showed significantly different expression among previously identified TGF-β responsive gene signature and IFN-γ signature in responders than in non-responders was identified and VRGS score was calculated by a mean value of VRGS filtered-in gene expressions divided by 6 house-keeping gene expressions.ResultsAs of July 1, 2020, of the total evaluable 24 patients, 71% were CMS4 subtype and 33% were with high TMB (≥10 mut/Mb). Clinical benefit rate was 33.3% including 3 PR and 1 iPR patients. No significant associations in response rate were observed with CMS subtypes or TMB status. VRGS score was significantly enriched in responders than in non-responders (P value = 0.006; AUC = 0.836). A preliminary cut-off value of 2.179 resulted in 94% specificity and 75% sensitivity with 85.7% patients correctly classifying as a responder. After treatment of vactosertib plus pembrolizumab, TGF-β-related VRGS was significantly decreased and the extent of decrease was greater in responders, compared to non-responders.Ethics ApprovalThe study was approved by Ethics Board of Asan Medical Center, Yonsei University College of Medicine, Samsung Medical Center, and Seoul National University Bundang Hospital with approval number 2018-1215, 4-2018-0728, SMC 2018-07-146-006, and B-1808/487-003, respectively.ConclusionsDevelopment of VRGS as a predictive biomarker for this combination treatment with vactosertib and pembrolizumab is ongoing and its potential clinical utility for patient selection will be explored.Trial RegistrationNCT03724851
APA, Harvard, Vancouver, ISO, and other styles
2

El Fekih, Rania, James Hurley, Vasisht Tadigotla, et al. "Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection." Journal of the American Society of Nephrology 32, no. 4 (2021): 994–1004. http://dx.doi.org/10.1681/asn.2020060850.

Full text
Abstract:
BackgroundDeveloping a noninvasive clinical test to accurately diagnose kidney allograft rejection is critical to improve allograft outcomes. Urinary exosomes, tiny vesicles released into the urine that carry parent cells’ proteins and nucleic acids, reflect the biologic function of the parent cells within the kidney, including immune cells. Their stability in urine makes them a potentially powerful tool for liquid biopsy and a noninvasive diagnostic biomarker for kidney-transplant rejection.MethodsUsing 192 of 220 urine samples with matched biopsy samples from 175 patients who underwent a clinically indicated kidney-transplant biopsy, we isolated urinary exosomal mRNAs and developed rejection signatures on the basis of differential gene expression. We used crossvalidation to assess the performance of the signatures on multiple data subsets.ResultsAn exosomal mRNA signature discriminated between biopsy samples from patients with all-cause rejection and those with no rejection, yielding an area under the curve (AUC) of 0.93 (95% CI, 0.87 to 0.98), which is significantly better than the current standard of care (increase in eGFR AUC of 0.57; 95% CI, 0.49 to 0.65). The exosome-based signature’s negative predictive value was 93.3% and its positive predictive value was 86.2%. Using the same approach, we identified an additional gene signature that discriminated patients with T cell–mediated rejection from those with antibody-mediated rejection (with an AUC of 0.87; 95% CI, 0.76 to 0.97). This signature’s negative predictive value was 90.6% and its positive predictive value was 77.8%.ConclusionsOur findings show that mRNA signatures derived from urinary exosomes represent a powerful and noninvasive tool to screen for kidney allograft rejection. This finding has the potential to assist clinicians in therapeutic decision making.
APA, Harvard, Vancouver, ISO, and other styles
3

Tran, Ivy, Alejandro Vargas, Reid Wilkins, et al. "Abstract 6689: Whole genome cell-free tumor DNA mutational signatures from blood for early detection of recurrence of low stage lung adenocarcinoma." Cancer Research 83, no. 7_Supplement (2023): 6689. http://dx.doi.org/10.1158/1538-7445.am2023-6689.

Full text
Abstract:
Abstract Introduction: Lung cancer remains the leading cause of cancer-related deaths. Surgery is the best option for early lung cancer, and the role of adjuvant therapy remains controversial. Liquid biopsy offers a noninvasive approach to monitor cancer burden. Targeted sequencing of circulating cell free tumor DNA (ctDNA) in blood has shown success for diagnosis; however, low tumor burden and dynamic evolution of low stage disease is challenging for targeted panels. Thus, we hypothesized that a whole genome sequencing (WGS)-derived patient specific mutational signature from a matched tumor-normal WGS can provide sensitive and specific approach to detect mutations and copy numbers in ctDNA for monitoring of lung adenocarcinoma patients. Methods: We successfully profiled 50 Stage 1 or 2 lung adenocarcinomas. ctDNA was extracted from 1-2 mL of plasma, tumor DNA was extracted from pathology tissue and normal germline DNA from the white blood cells. WGS using was performed on matched tumor and normal DNA, and ctDNA extracted from plasma. WGS coverage was 40x for matched tumor-normal and 20x for ctDNA. We derived a personalized mutational pattern for each tumor and used an AI-based error suppression model for quantification and ultra-sensitive detection of ctDNA in plasma samples. A patient-specific personalized genome-wide compendium of somatic mutations and copy numbers was established and ctDNA tested at 3 to 18 available time points during the therapy or follow up. A personalized mutational signature for detection ctDNA from WGS was quantified and the ctDNA Tumor Fraction (TF) was compared to the clinical status and time to recurrence. Results: Tumor specific signatures were derived from matched tumor-normal samples with >5% tumor purity and <30% duplications rate. Out of all patients, 33 patients showed no recurrence and 12 recurred. Tumor-specific signatures detected the presence of the tumor signature in plasma with TF as low as 10−5. Based on positive minimal residual disease in plasma, the recurrence prediction sensitivity was 0.75 and specificity 0.82, with positive predictive value of 0.6 and negative predictive value 0.9. WGS ctDNA predicted recurrence with a median lead time of 508 days before clinical/imaging recurrence. In one case we were able to identify the second primary by deconvoluting known and novel ctDNA mutations. ctDNA mutational profiles enabled identification of smoking mutational signature matching clinical history, and APOBEC and ageing signatures as well as tumor mutational burden. Conclusions: Patient-specific WGS tumor signature from plasma derived ctDNA enables specific and ultrasensitive tracking of minimal residual disease in low stage lung adenocarcinoma patients. Molecularly positive status can be used to predict recurrence and identify patients with clinical low stage disease that may benefit from adjuvant therapy. Citation Format: Ivy Tran, Alejandro Vargas, Reid Wilkins, Isabella Pizzillo, Kenneth Tokoro, Danielle Afterman, Tomer Lauterman, Maja Kuzman, Santiago Gonzalez, Dunja Glavas, James Smadbeck, Dillon Maloney, Jurica Levatic, Samuel Phillips, Sunil Deochand, Michael Yahalom, Ryan Ptashkin, Iman Tavassoly, Zohar Donenhirsh, Eric White, Ravi Kandasamy, Ury Alon, Paz Polak, Boris Oklander, Asaf Zviran, Matija Snuderl, Harvey I. Pass. Whole genome cell-free tumor DNA mutational signatures from blood for early detection of recurrence of low stage lung adenocarcinoma. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6689.
APA, Harvard, Vancouver, ISO, and other styles
4

Pratama, Edwin Yoga, and Nabitatus Sa'adah. "Penggunaan Tanda Tangan Elektronik Pada Sertipikat Hak Tanggungan Elektronik." Notarius 16, no. 3 (2022): 1234–50. http://dx.doi.org/10.14710/nts.v16i3.41661.

Full text
Abstract:
AbstractAn digital signature is an electronically generated signature that functions the same as a regular signature on paper documents. Electronic documentscan be categorized as written evidence, legal principle that makes it difficult to developt the use of electronic documents, the document must be viewable, sent and stored in paper form and also digital data is data that is very vulnerable to engineering. The theory of this research is Gustav Radbruch's theory of legal goals, it is necessary to use the principle of the primacy of three basic values that are the objectives of the law, namely: legal justice, legal expediency and legal certainty and the writing method used is normative juridical. The results is that this electronic signature has been registered with the BSSN, therefore the electronic signature issued is guaranteed because BSSN is one of the bodies trusted by the State, UU ITE has recognized that electronic documents and electronic signatures can be used as legal and perfect evidence, the efforts of the national land agency office are that BPN already has two validated applications, namely veryds and PDF writer, BPN also has its own server only registered users can access the data.Keyword: digital signature; document; electronicAbstrakTanda tangan elektronik adalah tanda tangan yang dibuat secara elektronik, bertindak serupa dengan tanda tangan umumnya pada dokumen kertas. Dokumen elektronik bisa dikelompokkan selaku bukti tertulis, prinsip hukum yang mengakibatkan sukarnya pengembangan penggunaan serta dokumen elektronik, dokumen tersebut haruslah bisa dilihat, dikirim serta disimpan kedalam wujud kertas dan juga mengenai data digital merupakan data yang sangat rentan untuk di rekayasa. Teori penelitian ini adalah teori tujuan hukum Gustav Radbruch, perlunya menggunakan asas prioritas dari tiga nilai dasar yang menjadi tujuan hukum, diantaranya: keadilan hukum, kemanfaatan hukum, kepastian hukum serta metode penulisan yang dipergunakan ialah yuridis normatif. Hasil penelitian ini adalah bahwasanya tanda tangan elektronik ini sudah didaftarkan ke BSSN, maka dari itu tanda tangan elektronik yang dikeluarkan sudah terjamin karna BSSN salah satu badan yang dipercaya oleh Negara, UU ITE sudah mengakui bahwa dokumen elektronik serta tanda tangan elektronik mampu dipergunakan selaku alat bukti yang sah dan sempurna, upaya dari kantor badan pertanahan nasional yakni bahwa BPN telah memiliki dua aplikasi tervalidasi yakni veryds dan PDF writer, BPN juga telah memiliki server sendiri hanya pengguna terdaftar saja yang bisa mengakses data.Kata kunci: tanda tangan elektronik; dokumen; elektronik
APA, Harvard, Vancouver, ISO, and other styles
5

MAHER, A., S. KOSSA, M. KADDAH, and M. El-HUSSEINY. "VIBRATION SIGNATURE ANALYSIS OF TURBOJET ENGINES." International Conference on Aerospace Sciences and Aviation Technology 1, CONFERENCE (1985): 1–12. http://dx.doi.org/10.21608/asat.1985.26535.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Allen, S. L. "VOEvent authentication via XML digital signature." Astronomische Nachrichten 329, no. 3 (2008): 298–300. http://dx.doi.org/10.1002/asna.200710949.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Setiawan, Yudhi. "Implementasi Asas Kebebasan Berkontrak dan Asas Keseimbangan Terhadap Perjanjian Pembiayaan Kendaraan Bermotor." JATISWARA 31, no. 3 (2017): 341–59. http://dx.doi.org/10.29303/jtsw.v31i3.53.

Full text
Abstract:
This study was conducted to analyze the agreement used in the process of player’s transfer based on the principle of freedom of contract and the obstacles encountered in the implementation of contract manufacturing for professional players. The method used in this study was a empirical normative legal research, by using the statute approach, concept approach and case approach. The results showed that the written contract made between players and the club showed the existence of freedom of the parties in making the contract, in which the parties have made a contract with the evidence of a signature by the parties. As for the obstacles in the process of professional players’ transfer were the factor of age or minors, financial shortages and the number of players injured at the time when the transfer was opened.
APA, Harvard, Vancouver, ISO, and other styles
8

Kamal, A., H. Dahshan, and A. Rohiem. "An Elliptic Curve Threshold Group Signature Scheme." International Conference on Aerospace Sciences and Aviation Technology 15, AEROSPACE SCIENCES (2013): 1–9. http://dx.doi.org/10.21608/asat.2013.22082.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Fadhil, Andi Muh, Zulkifli Makkawaru, and Almusawir Almusawir. "ANALISIS KEKUATAN HUKUM PEMBACAAN AKTA NOTARIS MELALUI APLIKASI ZOOM." Clavia 22, no. 1 (2024): 15–26. http://dx.doi.org/10.56326/clavia.v22i1.4095.

Full text
Abstract:
Penelitian ini bertujuan untuk mengetahui keabsahan akta notaris yang dibacakan melalui aplikasi zoom dan, kekuatan hukum digital signature melalui aplikasi zoom, Jenis penelitian yang digunakan adalah yuridis empiris yaitu dengan melakukan penelitian terhadap asas-asas hukum, sumber-sumber hukum seta mengacu pada norma-norma hukum yang terdapat dalam peraturan perundang-undangan yang bersifat teoritis ilmiah. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu Penelitian Pustaka dengan dengan membaca referensi hukum, perundang-undangan, serta dokumen-dokumen, dan penelitian lapangan dengan melakukan wawancara secara langsung Notaris-Notaris di Kota Makassar, Sulawesi Selatan. Berdasarkan hasil penelitian dapat disimpulkan bahwa Kekuatan hukum pembacaan akta Notaris melalui aplikasi zoom untuk saat ini belum dapat dilakukan, selain melangar kode etik Notaris karna merugikan pihak penghadap dimana terjadi gradasi akta autentik menjadi akta dibawa tangan, juga tidak mempunyai kekuatan hukum dan, Penggunaan digital signature menggunakan aplikasi zoom adalah sah dan berkekuatan hukum selama memenuhi ketentuan Pasal 11 ayat (1) Undang-Undang Nomor 11 Tahun 2008 tenteng Informasi Dan Transaksi Elektronik jo Pasal 59 ayat (3) Peraturan Pemerintah Republik Indonesia Nomor 71 Tahun 2019 tentang Penyelenggaraan Sistem Dan Transaksi Elektronik, namun terbatas pada penggunaannya, bukan sebagai akta autentik This research is to determine the validity of notarial deeds read via the Zoom application and the legal strength of digital signatures via the Zoom application. The type of research used is empirical juridical, namely by conducting research on legal principles, legal sources and referring to legal norms. contained in legal regulations that are scientific theoretical in nature. The data collection technique used in this research is library research by reading legal references, legislation, and documents, and field research by conducting direct interviews with notaries in Makassar City, South Sulawesi. Based on the results of the research, it can be concluded that the legal force of reading a Notary's deed via the Zoom application is currently not possible, apart from violating the Notary's code of ethics because it is detrimental to the presenting party where there is a gradation of an authentic deed to a hand-carried deed, it also has no legal force and, the use of a digital signature using the zoom application is legal and has legal force as long as it meets the provisions of Article 11 paragraph (1) of Law Number 11 of 2008 concerning Electronic Information and Transactions in conjunction with Article 59 paragraph (3) of the Government Regulation of the Republic of Indonesia Number 71 of 2019 concerning Implementation of Electronic Systems and Transactions, but limited to its use, not as an authentic deed.
APA, Harvard, Vancouver, ISO, and other styles
10

Rehulina, Rehulina. "KEABSAHAN DIGITAL SIGNATURE DALAM PERJANJIAN E-COMMERCE." DOKTRINA: JOURNAL OF LAW 1, no. 1 (2018): 45. http://dx.doi.org/10.31289/doktrina.v1i1.1609.

Full text
Abstract:
<p>Transaksi perdagangan elektronik atau <em>electronic commerce transaction </em>yang biasa disebut dengan <em>e-commerce </em>adalah kegiatan dalam bidang perniagaan yang banyak menggunakan jaringan internet dalam melakukan penawaran dan permintaan.Menurut Mariam Darus Badrulzaman istilah lain yang dipakai untuk <em>e-commerce </em>di antaranya kontrak dagang elektronik, kontrak siber, transaksi dagang elektronik, dan kontrak web.<em>Electronic Commerce transaction </em>adalah transaksi dagang antara penjual dan pembeli untuk menyediakan barang, jasa, atau mengambil alih hak melalui media elektronik dimana para pihak tidak hadir secara fisik dan menggunakan jaringan umum dengan sistem terbuka yaitu internet.Metode penelitian yang digunakan adalah yuridis normatif yang merupakan suatu metode penelitian yang mengacu pada norma-norma hukum yang terdapat dalam peraturan perundang-undangan.Penelitian yuridis normatif yang dilakukan dengan upaya menganalisis permasalahaan dalam penelitian melalui pendekatan asas-asas hukum serta mengacu pada norma-norma hukum yang terdapat dalam peraturan yang erat kaitannya dengan pokok bahasan. Mengutip istilah Ronald Dworkin, penelitian ini juga disebut dengan penelitian doctrinal (<em>doctrinal research</em>), yaitu suatu penelitian yang menganalisis hukum baik yang tertulis di dalam buku (<em>lawas written in the book</em>), maupun yang diputuskan oleh hakim melalui proses pengadilan (<em>law as it is decided by the judge through judicial prcess</em>).Tanda tangan digital harus diterima keabsahannya sebagai tanda tangan dengan alasan sebagai berikut:Tanda tangan digital merupakan tanda tangan yang bisa dibubuhkan oleh seseorang atau beberapa orang yang diberikan kuasa oleh orang lain yang berkehendak untuk diikat secara hukum;Sebuah tanda tangan digital dapat dimasukkan dengan menggunakan peralatan mekanik, sebagaimana tanda tangan tradisional/konvensional;Sebuah tanda tangan digital sangat mungkin bersifat lebih aman atau lebih tidak aman sebagaimana kemungkinan ini juga terjadi pada tanda tangan tradisional/konvensional;Waktu membubuhkan tanda tangan digital, niat sipenandatangan yang menjadi keharusan juga bisa dipenuhi sebagaimana pada tanda tangan tradisional/konvensional.</p>
APA, Harvard, Vancouver, ISO, and other styles
11

Starman, Terri Woods, and Shane Abbitt. "Evaluating Genetic Relationships of Geranium Using Arbitrary Signatures from Amplification Profiles." HortScience 32, no. 7 (1997): 1288–91. http://dx.doi.org/10.21273/hortsci.32.7.1288.

Full text
Abstract:
Our objective was to distinguish between eight cultivars of two geranium species, Pelargonium ×hortorum L.H. Bailey (cutting and seed geranium) and Pelargonium peltatum (L.) L'Hér. ex Ait. (ivy geranium), and evaluate their genetic relationships using the nucleic acid scanning techniques of DNA amplification fingerprinting (DAF) and/or arbitrary signatures from amplification profiles (ASAP). Cultivars used in the study represented three commercial types: cutting, seed, and ivy geranium. Two seed geranium cultivars from each of the Dynamo and Orbit series were included. Cutting geranium cultivars were `Designer Lilac Chiffon' and `Starburst Red' and the ivy geraniums were `Bernardo Guiber' and `Vinco Guivin'. The ASAP amplification protocol used one of two arbitrary octamer primers, followed by reamplification with one of four different minihairpin primers. ASAP profiles were complex, with 66% of bands being polymorphic and useful in distinguishing between cultivars. Genetic relationships were evaluated by principal coordinate analysis and cluster analysis based on the Jaccard distance estimator. This analysis grouped cultivars by species according to commercial type, i.e., seed geraniums were in one large group, the cutting geraniums were grouped together, and the ivy geraniums were a separate branch.
APA, Harvard, Vancouver, ISO, and other styles
12

Neyman, Shelvie, and Selfi Qisthina. "Pengamanan Internet of Things untuk Tanda Tangan Digital Menggunakan Algoritme Elgamal Signature Scheme." Jurnal Ilmu Komputer dan Agri-Informatika 8, no. 1 (2021): 69–78. http://dx.doi.org/10.29244/jika.8.1.69-78.

Full text
Abstract:
Internet of Things (IoT) memungkinkan suatu objek menghasilkan data dan bertukar data. Pengaplikasian IoT menggunakan mikrokontroler seperti Arduino belum memiliki fitur untuk menjaga keamanan data di dalamnya. Selain itu, Arduino memiliki kapabilitas komputasi terbatas. Oleh karena itu, perlu diterapkan kriptografi dengan algoritme yang memiliki komputasi rendah pada Arduino untuk menjaga keamanan data. Penjagaan keamanan data terutama pada keaslian asal data, dilakukan dengan menggunakan tanda tangan digital. Penerapan tanda tangan digital dapat dilakukan salah satunya dengan algoritme Elgamal signature scheme. Penerapan tanda tangan digital menggunakan algoritme Elgamal signature scheme berhasil diterapkan pada perangkat Arduino Uno untuk melakukan tanda tangan digital dan verifikasi. Kinerja algoritme Elgamal signature scheme dilihat dari analisis waktu eksekusi dan analisis keamanan algoritme. Waktu eksekusi proses tanda tangan digital membutuhkan waktu lebih lama dibandingkan dengan waktu eksekusi proses verifikasi. Algoritme Elgamal signature scheme membutuhkan waktu dua kali lebih lama karena banyaknya perhitungan sistematis pada perangkat Arduino Uno. Proses verifikasi terbukti gagal jika ada perubahan data dan pasangan tanda tangan digital.
 Kata Kunci: Arduino, Elgamal signature scheme, internet of things, kriptografi, tanda tangan digital.
APA, Harvard, Vancouver, ISO, and other styles
13

Schneider, P. C., H. M. Günther, and J. Robrade. "Stellar X-ray accretion signatures." Astronomische Nachrichten 338, no. 2-3 (2017): 201–6. http://dx.doi.org/10.1002/asna.201713331.

Full text
APA, Harvard, Vancouver, ISO, and other styles
14

Trigiano, R. N., M. C. Scott, and G. Caetano-Anollés. "Arbitrary Signatures from Amplification Profiles (ASAP) Distinguishes Somatic and Radiation-induced Mutations in the `Charm' Series of Chrysanthemum." HortScience 32, no. 3 (1997): 500B—500. http://dx.doi.org/10.21273/hortsci.32.3.500b.

Full text
Abstract:
Four chrysanthemum (Dendranthema grandiflora) spontaneous and radiation-induced sports from the cultivar `Charm' and phenotypically differing only in flower color were individually characterized using arbitrary signatures from amplification profiles (ASAP). ASAP analysis is based on a two-step arbitrary primer amplification procedure that produces “fi ngerprints of fingerprints.” In the first step, `Charm', `Dark Charm', `Dark Bronze Charm', `Salmon Charm', and `Coral Charm' were fingerprinted by DNA amplification fingerprinting (DAF) with standard octamer arbitrary primers. Diluted products from three monomorphic fingerprints for each cultivar were subsequently reamplified using four minihairpin decamer primers. Each of the 12 ASAP profiles revealed polymorphic loci that were used to uniquely identify cultivars and estimate genetic relationships. The ASAP technique permits identification of previously genetically indistinguishable plant material and should facilitate marker assisted breeding and protection of ownership rights.
APA, Harvard, Vancouver, ISO, and other styles
15

Trigiano, R. N., M. C. Scott, and G. Caetano-Anollés. "Arbitrary Signatures From Amplification Profiles (ASAP) Distinguishes Somatic and Radiation Induced Mutations in the `Charm' Series of Chrysanthemum." HortScience 32, no. 4 (1997): 593C—593. http://dx.doi.org/10.21273/hortsci.32.4.593c.

Full text
Abstract:
Four chrysanthemum (Dendranthema grandiflora) spontaneous and radiation-induced sports from the cultivar `Charm' and phenotypically differing only in flower color were individually characterized using arbitrary signatures from amplification profiles (ASAP). ASAP analysis is based on a two-step arbitrary primer amplification procedure that produces “fingerprints of fingerprints.” In the first step, `Charm', `Dark Charm', `Dark Bronze Charm', `Salmon Charm', and `Coral Charm' were fingerprinted by DNA amplification fingerprinting (DAF) with standard octamer arbitrary primers. Diluted products from three monomorphic fingerprints for each cultivar were subsequently reamplified using four minihairpin decamer primers. Each of the 12 ASAP profiles revealed about 30% polymorphic loci and some were used to uniquely identify cultivars and estimate genetic relationships. The ASAP technique permits identification of previously genetically indistinguishable plant material and should facilitate marker assisted breeding and protection of ownership rights.
APA, Harvard, Vancouver, ISO, and other styles
16

Trigiano, R. N., M. C. Scott, and G. Caetano-Anollés. "Genetic Signatures from Amplification Profiles Characterize DNA Mutation in Somatic and Radiation-induced Sports of Chrysanthemum." Journal of the American Society for Horticultural Science 123, no. 4 (1998): 642–46. http://dx.doi.org/10.21273/jashs.123.4.642.

Full text
Abstract:
The chrysanthemum (Dendranthema grandiflora Tzvelev.) cultivars `Dark Charm', `Salmon Charm', `Coral Charm' and `Dark Bronze Charm' are either radiation-induced mutants or spontaneous sports of `Charm' and constitute a family or series of plants that primarily differ in flower color. These cultivars, which were difficult to differentiate genetically by DNA amplification fingerprinting (DAF), were easily identified by using arbitrary signatures from amplification profiles (ASAP). Genomic DNA was first amplified with three standard octamer arbitrary primers, all of which produced monomorphic profiles. Products from each of these DNA fingerprints were subsequently reamplified using four minihairpin decamer primers. The 12 primer combinations produced signatures containing ≈37% polymorphic character loci, which were used to estimate genetic relationships between cultivars. Forty-six (32%) unique amplification products were associated with individual cultivars. The number of ASAP polymorphisms detected provided an estimate of the mutation rate in the mutant cultivars, ranging from 0.03% to 1.6% of nucleotide changes within an average of 18 kb of arbitrary amplified DAF sequence. The ASAP technique permits the clear genetic identification of somatic mutants and radiation-induced sports that are genetically highly homogeneous and should facilitate marker assisted breeding and protection of plant breeders rights of varieties or cultivars.
APA, Harvard, Vancouver, ISO, and other styles
17

Baup, Frdric, Eric Mougin, Pierre Hiernaux, Armand Lopes, Patricia De Rosnay, and Isabelle Chenerie. "Radar Signatures of Sahelian Surfaces in Mali Using ENVISAT-ASAR Data." IEEE Transactions on Geoscience and Remote Sensing 45, no. 7 (2007): 2354–63. http://dx.doi.org/10.1109/tgrs.2007.893824.

Full text
APA, Harvard, Vancouver, ISO, and other styles
18

GHONIEMY, SAID. "Dynamic Behavior of Improved Compact Signature Analysis Based on LFSR." International Conference on Aerospace Sciences and Aviation Technology 7, ASAT CONFERENCE (1997): 1–16. http://dx.doi.org/10.21608/asat.1997.25444.

Full text
APA, Harvard, Vancouver, ISO, and other styles
19

El-Barbary, Khairy, Elsaid Azouz, Ashraf Mamdoh, and Mohammed Abou El-Azm. "CONSTELLATION SHAPE AS A ROBUST SIGNATURE FOR DIGITAL MOULATION RECOGNITION." International Conference on Aerospace Sciences and Aviation Technology 11, ASAT CONFERENCE (2011): 1–15. http://dx.doi.org/10.21608/asat.2011.27182.

Full text
APA, Harvard, Vancouver, ISO, and other styles
20

Nikolakis, D., A. Y. F. Li Yim, D. Lartey, et al. "P0172 In silico drug repurposing approach for the discovery of therapeutics for intestinal fibrosis in crohn’s disease." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i570—i571. https://doi.org/10.1093/ecco-jcc/jjae190.0346.

Full text
Abstract:
Abstract Background Intestinal fibrosis in Crohn’s disease (CD) can lead to stricture formation and other disease-related complications.1,2 Given the lack of anti-fibrotic drugs, current treatment strategies are limited to anti-inflammatory therapies, endoscopic balloon dilation and surgery.1 Our aim was to identify compounds and druggable targets that can reverse the gene expression signature in mucosal fibroblasts associated with intestinal fibrosis. Methods A signature associated with fibrotic CD was derived from three publicly available transcriptomic datasets of fibroblasts isolated from fibrostenotic strictures of CD patients. We conducted a meta-regression analysis across the transcriptomic datasets to identify significant differentially expressed genes (DEGs) associated with fibrostenotic CD. Three drug repurposing platforms (iLINCS, L1000 CDS2 and CLUE io), connected to the NIH LINCS database,3,4 were used to identify compounds that could reverse the fibrotic signature, ranked by their anti-fibrotic potential using the CoDReS (Composite Drug Reranking Scoring) tool. Transcription factors and miRNAs targeting the fibrostenotic signature were identified via the TRRUST and miRWalk databases. A gene interaction network was constructed, incorporating transcription factors (TRRUST TF), miRNAs and DEGs. Drugs targeting key network components were identified using the DGiDb database. Results Via the analysis of combined transcriptomic datasets from fibrostenotic- versus non-stenosis-associated mucosal fibroblasts, fibroblast activation protein (FAP), IL7 receptor and transcription factor AP-2 gamma, emerged as the most significantly upregulated genes in fibrostenotic CD (Figure 1). Out of 6,783 compounds, PI3K/Akt/mTOR inhibitors, Src kinase family inhibitors and histone deacetylase inhibitors were predicted as being most effective in reversing this pathologic gene signature. The gene interaction network revealed 15 hub genes as central components with the most interconnections (Table 1). Among these top 15 key gene regulators, IL6, PPARγ and angiotensin receptor type 1 (AGTR1) were the highest ranked druggable targets, based on the drug-gene interaction analysis. Conclusion Our in silico drug repurposing approach identified several potential anti-fibrotic compounds and druggable targets for the treatment of CD-associated intestinal fibrosis. These findings open novel avenues for the development of anti-fibrotic drugs and provide a foundation for future research on cell and pathway-specific mechanisms driving fibrosis in CD. References 1.Bettenworth D, Bokemeyer A, Baker M, Mao R, Parker CE, Nguyen T, Ma C, Panés J, Rimola J, Fletcher JG, Jairath V, Feagan BG, Rieder F; Stenosis Therapy and Anti-Fibrotic Research (STAR) Consortium. Assessment of Crohn’s disease-associated small bowel strictures and fibrosis on cross-sectional imaging: a systematic review. Gut. 2019 Jun;68(6):1115-1126. doi: 10.1136/gutjnl-2018-318081. Epub 2019 Apr 3. PMID: 30944110; PMCID: PMC6580870. 2.Mukherjee PK, Nguyen QT, Li J, Zhao S, Christensen SM, West GA, Chandra J, Gordon IO, Lin S, Wang J, Mao R, Czarnecki D, Rayan C, Goren I, Banerjee S, Kotak P, Plesec T, Lal S, Fabre T, Asano S, Bound K, Hart K, Park C, Martinez R, Dower K, Wynn TA, Hu S, Naydenov N, Decaris M, Turner S, Holubar SD, Steele SR, Fiocchi C, Ivanov AI, Kravarik KM, Rieder F. Stricturing Crohn’s Disease Single-Cell RNA Sequencing Reveals Fibroblast Heterogeneity and Intercellular Interactions. Gastroenterology. 2023 Nov;165(5):1180-1196. doi: 10.1053/j.gastro.2023.07.014. Epub 2023 Jul 26. PMID: 37507073. 3.Keenan AB, Jenkins SL, Jagodnik KM, et al. (2018). The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Syst. 2018;6(1):13-24. doi:10.1016/j.cels.2017.11.001. 4.Lamb, Justin et al. (2006). The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (New York, N.Y.) vol. 313,5795: 1929-35. doi:10.1126/science.1132939.
APA, Harvard, Vancouver, ISO, and other styles
21

Trigiano, R. N., M. H. Ament, M. T. Windham, and J. K. Moulton. "Genetic Profiling of Red-Bracted Cornus kousa Cultivars Indicates Significant Cultivar Synonomy." HortScience 39, no. 3 (2004): 489–92. http://dx.doi.org/10.21273/hortsci.39.3.489.

Full text
Abstract:
Cornus kousa Hance (Korean or kousa dogwood) cultivars are increasingly used as landscape plants because they lack the disease and insect problems typically associated with the native C. florida L. (flowering dogwood). A number of red-bracted kousa dogwood cultivars are now available and several are phenotypically indistinguishable from one another. Plants of six cultivars obtained from three nurseries were characterized genetically using deoxyribonucleic acid (DNA) amplification fingerprinting (DAF) and arbitrary signatures from amplification profiles (ASAP). DAF profiles of three red-bracted cultivars—`Rosabella', `Satomi' and `Heart Throb'—were nearly identical. ASAP also failed to clearly differentiate these cultivars and indicated consistent genetic similarities. In contrast, another red-bracted cultivar `Christian Prince' and two white-bracted cultivars—`Little Beauty' and `Samaritan'—were identified and separated from all other cultivars by both DAF and ASAP techniques.
APA, Harvard, Vancouver, ISO, and other styles
22

Rudman-Melnick, Valeria, Mike Adam, Andrew Potter, et al. "Single-Cell Profiling of AKI in a Murine Model Reveals Novel Transcriptional Signatures, Profibrotic Phenotype, and Epithelial-to-Stromal Crosstalk." Journal of the American Society of Nephrology 31, no. 12 (2020): 2793–814. http://dx.doi.org/10.1681/asn.2020010052.

Full text
Abstract:
BackgroundCurrent management of AKI, a potentially fatal disorder that can also initiate or exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular pathways perturbed in AKI is needed to identify targets with potential to lead to improved treatment.MethodsWe performed single-cell RNA sequencing (scRNA-seq) with the clinically relevant unilateral ischemia-reperfusion murine model of AKI at days 1, 2, 4, 7, 11, and 14 after AKI onset. Using real-time quantitative PCR, immunofluorescence, Western blotting, and both chromogenic and single-molecule in situ hybridizations, we validated AKI signatures in multiple experiments.ResultsOur findings show the time course of changing gene expression patterns for multiple AKI stages and all renal cell types. We observed elevated expression of crucial injury response factors—including kidney injury molecule-1 (Kim1), lipocalin 2 (Lcn2), and keratin 8 (Krt8)—and of several novel genes (Ahnak, Sh3bgrl3, and Col18a1) not previously examined in kidney pathologies. AKI induced proximal tubule dedifferentiation, with a pronounced nephrogenic signature represented by Sox4 and Cd24a. Moreover, AKI caused the formation of “mixed-identity cells” (expressing markers of different renal cell types) that are normally seen only during early kidney development. The injured tubules acquired a proinflammatory and profibrotic phenotype; moreover, AKI dramatically modified ligand-receptor crosstalk, with potential pathologic epithelial-to-stromal interactions. Advancing age in AKI onset was associated with maladaptive response and kidney fibrosis.ConclusionsThe scRNA-seq, comprehensive, cell-specific profiles provide a valuable resource for examining molecular pathways that are perturbed in AKI. The results fully define AKI-associated dedifferentiation programs, potential pathologic ligand-receptor crosstalk, novel genes, and the improved injury response in younger mice, and highlight potential targets of kidney injury.
APA, Harvard, Vancouver, ISO, and other styles
23

GhONIEMY, M., REDA SEIREG, SAYED BAHGAT, and AHMED MOHAMED. "IMPROVED COMPACT SIGNATURE ANALYZER BASED ON MULTIPLE INPUT SHIFT REGISTER ( MISR)." International Conference on Aerospace Sciences and Aviation Technology 7, ASAT CONFERENCE (1997): 1–16. http://dx.doi.org/10.21608/asat.1997.25446.

Full text
APA, Harvard, Vancouver, ISO, and other styles
24

Lindsey, C., H. Schunker, and P. S. Cally. "Magnetoseismic signatures and flow diagnostics beneath magnetic regions." Astronomische Nachrichten 328, no. 3-4 (2007): 298–304. http://dx.doi.org/10.1002/asna.200610733.

Full text
APA, Harvard, Vancouver, ISO, and other styles
25

Lorenz, L. C. "Trans-Planckian signatures in the cosmic microwave background?" Astronomische Nachrichten 328, no. 8 (2007): 867–70. http://dx.doi.org/10.1002/asna.200710791.

Full text
APA, Harvard, Vancouver, ISO, and other styles
26

Ndonga, Dennis. "Addressing the Challenges Facing the Use of E-Signatures Within the ASEAN Single Window." Global Trade and Customs Journal 12, Issue 5 (2017): 184–89. http://dx.doi.org/10.54648/gtcj2017025.

Full text
Abstract:
On December 2005, the ASEAN member states passed the ASEAN Single Window (ASW) Agreement which paved the way for the implementation of a regional single window system that would integrate the members’ National Single Window (NSW) systems. This regional system is expected to facilitate trade within the ASEAN Economic Community. However, the successful operation of these systems largely depends the presence of a legal framework that would support the cross-jurisdictional recognition of members’ electronically authenticated documents that are exchanged between the NSWs and ASW. This article explores the role of e-signatures in single window operation, and assesses the challenges facing the cross-jurisdictional recognition of e-signatures under the ASW.
APA, Harvard, Vancouver, ISO, and other styles
27

Tran, Ivy, Kristyn Galbraith, Guisheng Zhao, et al. "Abstract 3401: Whole genome cell-free tumor DNA mutational signatures for noninvasive monitoring of pediatric brain cancers." Cancer Research 82, no. 12_Supplement (2022): 3401. http://dx.doi.org/10.1158/1538-7445.am2022-3401.

Full text
Abstract:
Abstract Introduction: Liquid biopsy offers a noninvasive approach to monitor cancer burden during therapy and surveillance period. However, in pediatric brain cancers, liquid biopsy methods from the blood have been unsuccessful due to a low tumor burden and low number of mutations in coding regions. We hypothesized that a whole genome sequencing (WGS)-derived patient specific mutational signature from a matched tumor-normal WGS can provide a sensitive and specific approach to detect mutations in circulating cell free tumor DNA (ctDNA) and provide blood-based monitoring in pediatric patients with brain tumor. Methods: All tumors were analyzed and molecularly subclassified using whole genome DNA methylation profiling and machine learning classifier. Tumor DNA was extracted from pathology tissue and normal germline DNA from the white blood cells, while ctDNA was extracted from 1-2 mL of post-surgery or follow-up plasma samples, WGS was applied to sequence DNA from matched tumor-normal and plasma samples. WGS coverage was 40x for matched tumor-normal DNA and 20x for ctDNA. Using the C2i assay, we derived a personalized mutational pattern for each tumor and used an AI-based error suppression model for quantification and ultra-sensitive detection of ctDNA in plasma samples. A patient-specific personalized genome-wide compendium of somatic mutations was established and ctDNA tested at 1 to 3 available time points during the therapy or surveillance period. An AI-based error suppression model was implemented to filter out the noise in the cell free DNA (cfDNA) while the personalized mutational signature was used to detect the ctDNA in the cfDNA and to amplify the somatic signal contained in it. The ctDNA Tumor Fraction (TF) was compared to the clinical status and MR-based imaging. Results: We profiled 7 pediatric brain tumors, including 2 medulloblastomas (one Group 3, one Group 4), 3 pediatric glioblastomas IDH wild-type, 1 ependymoma PFA subtype and one low grade ganglioglioma. Tumor specific signatures were identified and detected in the plasma of 5 patients with clinical disease with a TF range 0.02-0.0005 but not in 2 patients with no tumor at the time of blood collection. In two children with a medulloblastoma and glioblastoma, the decrease of tumor fraction in ctDNA over 2 (TF: 0.002 to 0.0009) and 3 time points (TF: 0.0005 to undetectable), respectively, correlated with response to therapy based on imaging. Conclusions: Patient-specific WGS tumor signature in ctDNA from blood can be used for sensitive monitoring of children with brain tumors. Citation Format: Ivy Tran, Kristyn Galbraith, Guisheng Zhao, Robyn Borsuk, Joyce Varkey, Sharon Gardner, Jeffrey Allen, David Harter, Jeffrey Wisoff, Eveline T. Hidalgo, Sunil Deochand, Dillon Maloney, Danielle Afterman, Tomer Lauterman, Noah Friedman, Imane Bourzgui, Nidhi Ramaraj, Zohar Donenhirsh, Ronel Veksler, Jonathan Rosenfeld, Ravi Kandasamy, Iman Tavassoly, Boris Oklander, G. Praveen Raju, Theodore Nicolaides, Asaf Zviran, Matija Snuderl. Whole genome cell-free tumor DNA mutational signatures for noninvasive monitoring of pediatric brain cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3401.
APA, Harvard, Vancouver, ISO, and other styles
28

Gowrikumar, Saiprasad, Mark Primeaux, Kristina Pravoverov, et al. "A Claudin-Based Molecular Signature Identifies High-Risk, Chemoresistant Colorectal Cancer Patients." Cells 10, no. 9 (2021): 2211. http://dx.doi.org/10.3390/cells10092211.

Full text
Abstract:
Identifying molecular characteristics that are associated with aggressive cancer phenotypes through gene expression profiling can help predict treatment responses and clinical outcomes. Claudins are deregulated in colorectal cancer (CRC). In CRC, increased claudin-1 expression results in epithelial-to-mesenchymal transition and metastasis, while claudin-7 functions as a tumor suppressor. In this study, we have developed a molecular signature based on claudin-1 and claudin-7 associated with poor patient survival and chemoresistance. This signature was validated using an integrated approach including publicly available datasets and CRC samples from patients who either responded or did not respond to standard-of-care treatment, CRC cell lines, and patient-derived rectal and colon tumoroids. Transcriptomic analysis from a patient dataset initially yielded 23 genes that were differentially expressed along with higher claudin-1 and decreased claudin-7. From this analysis, we selected a claudins-associated molecular signature including PIK3CA, SLC6A6, TMEM43, and ASAP-1 based on their importance in CRC. The upregulation of these genes and their protein products was validated using multiple CRC patient datasets, in vitro chemoresistant cell lines, and patient-derived tumoroid models. Additionally, blocking these genes improved 5-FU sensitivity in chemoresistant CRC cells. Our findings propose a new claudin-based molecular signature that associates with poor prognosis as well as characteristics of treatment-resistant CRC including chemoresistance, metastasis, and relapse.
APA, Harvard, Vancouver, ISO, and other styles
29

Sharma, Kumar, Bethany Karl, Anna V. Mathew, et al. "Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease." Journal of the American Society of Nephrology 24, no. 11 (2013): 1901–12. http://dx.doi.org/10.1681/asn.2013020126.

Full text
APA, Harvard, Vancouver, ISO, and other styles
30

ferreira, Ricardo Melo, Tarek M. El-Achkar, Kimberly S. Collins, et al. "Spatial Transcriptomic Signatures in Murine AKI Models." Journal of the American Society of Nephrology 31, no. 10S (2020): 129. http://dx.doi.org/10.1681/asn.20203110s1129c.

Full text
APA, Harvard, Vancouver, ISO, and other styles
31

Karler, Casey, Kylea J. Parchert, James B. Ricken, et al. "Identification of Porphyrin-Silica Composite Nanoparticles using Atmospheric Solids Analysis Probe Mass Spectrometry." MRS Advances 4, no. 38-39 (2019): 2079–86. http://dx.doi.org/10.1557/adv.2019.217.

Full text
Abstract:
ABSTRACTPorphyrins are vital pigments involved in biological energy transduction processes. Their abilities to absorb light, then convert it to energy, have raised the interest of using porphyrin nanoparticles as photosensitizers in photodynamic therapy. A recent study showed that self- assembled porphyrin-silica composite nanoparticles can selectively destroy tumor cells, but detection of the cellular uptake of porphyrin-silica composite nanoparticles was limited to imaging microscopy. Here we developed a novel method to rapidly identify porphyrin-silica composite nanoparticles using Atmospheric Solids Analysis Probe-Mass Spectrometry (ASAP-MS). ASAP-MS can directly analyze complex mixtures without the need for sample preparation. Porphyrin-silica composite nanoparticles were vaporized using heated nitrogen desolvation gas, and their thermo-profiles were examined to identify distinct mass- to-charge (M/Z) signatures. HeLa cells were incubated in growth media containing the nanoparticles, and after sufficient washing to remove residual nanoparticles, the cell suspension was loaded onto the end of ASAP glass capillary probe. Upon heating, HeLa cells were degraded and porphyrin-silica composite nanoparticles were released. Vaporized nanoparticles were ionized and detected by MS. The cellular uptake of porphyrin-silica composite nanoparticles was identified using this ASAP-MS method.
APA, Harvard, Vancouver, ISO, and other styles
32

Caetano-Anollés, G., R. N. Trigiano, and M. T. Windham. "Fine Population Structure of Discula destructiva." HortScience 31, no. 4 (1996): 586a—586. http://dx.doi.org/10.21273/hortsci.31.4.586a.

Full text
Abstract:
Fifty-one isolates of Discula destructiva obtained from various Cornus species were evaluated using arbitrary signatures from amplification profiles (ASAP). ASAP analysis is based on dual-step arbitrary primer-based amplification procedure that produces “fingerprints of fingerprints” and in many instances increases detection of polymorphic DNA. This novel technique was able to distinguish groups of isolates from the northeast, middle and southeast range of the disease as well as western United States and Canada. The data supports the contention of recent and independent introduction of the disease on both east and west coasts, a genetic “bottleneck” that has limited diversity of the pathogen, and directionality of introduction of disease from coastal ports-of-entry to interior populations of C. florida and C. nuttalli.
APA, Harvard, Vancouver, ISO, and other styles
33

Gabici, S., and F. A. Aharonian. "Gamma ray signatures of ultra high energy cosmic ray accelerators." Astronomische Nachrichten 327, no. 5-6 (2006): 619–23. http://dx.doi.org/10.1002/asna.200610605.

Full text
APA, Harvard, Vancouver, ISO, and other styles
34

Randles, Michael J., Franziska Lausecker, Qingyang Kong, et al. "Identification of an Altered Matrix Signature in Kidney Aging and Disease." Journal of the American Society of Nephrology 32, no. 7 (2021): 1713–32. http://dx.doi.org/10.1681/asn.2020101442.

Full text
Abstract:
BackgroundAccumulation of extracellular matrix in organs and tissues is a feature of both aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial fibrosis accompany the decline in function, which current therapies cannot address, leading to organ failure. Although histologic and ultrastructural patterns of excess matrix form the basis of human disease classifications, a comprehensive molecular resolution of abnormal matrix is lacking.MethodsUsing mass spectrometry–based proteomics, we resolved matrix composition over age in mouse models of kidney disease. We compared the changes in mice with a global characterization of human kidneymatrix during aging and to existing kidney disease datasets to identify common molecular features.ResultsUltrastructural changes in basement membranes are associated with altered cell adhesion and metabolic processes and with distinct matrix proteomes during aging and kidney disease progression in mice. Within the altered matrix, basement membrane components (laminins, type IV collagen, type XVIII collagen) were reduced and interstitial matrix proteins (collagens I, III, VI, and XV; fibrinogens; and nephronectin) were increased, a pattern also seen in human kidney aging. Indeed, this signature of matrix proteins was consistently modulated across all age and disease comparisons, and the increase in interstitial matrix was also observed in human kidney disease datasets.ConclusionsThis study provides deep molecular resolution of matrix accumulation in kidney aging and disease, and identifies a common signature of proteins that provides insight into mechanisms of response to kidney injury and repair.
APA, Harvard, Vancouver, ISO, and other styles
35

Zhang, Weijia, Zhengzi Yi, Karen L. Keung, et al. "A Peripheral Blood Gene Expression Signature to Diagnose Subclinical Acute Rejection." Journal of the American Society of Nephrology 30, no. 8 (2019): 1481–94. http://dx.doi.org/10.1681/asn.2018111098.

Full text
Abstract:
BackgroundIn kidney transplant recipients, surveillance biopsies can reveal, despite stable graft function, histologic features of acute rejection and borderline changes that are associated with undesirable graft outcomes. Noninvasive biomarkers of subclinical acute rejection are needed to avoid the risks and costs associated with repeated biopsies.MethodsWe examined subclinical histologic and functional changes in kidney transplant recipients from the prospective Genomics of Chronic Allograft Rejection (GoCAR) study who underwent surveillance biopsies over 2 years, identifying those with subclinical or borderline acute cellular rejection (ACR) at 3 months (ACR-3) post-transplant. We performed RNA sequencing on whole blood collected from 88 individuals at the time of 3-month surveillance biopsy to identify transcripts associated with ACR-3, developed a novel sequencing-based targeted expression assay, and validated this gene signature in an independent cohort.ResultsStudy participants with ACR-3 had significantly higher risk than those without ACR-3 of subsequent clinical acute rejection at 12 and 24 months, faster decline in graft function, and decreased graft survival in adjusted Cox analysis. We identified a 17-gene signature in peripheral blood that accurately diagnosed ACR-3, and validated it using microarray expression profiles of blood samples from 65 transplant recipients in the GoCAR cohort and three public microarray datasets. In an independent cohort of 110 transplant recipients, tests of the targeted expression assay on the basis of the 17-gene set showed that it identified individuals at higher risk of ongoing acute rejection and future graft loss.ConclusionsOur targeted expression assay enabled noninvasive diagnosis of subclinical acute rejection and inflammation in the graft and may represent a useful tool to risk-stratify kidney transplant recipients.
APA, Harvard, Vancouver, ISO, and other styles
36

Shankar, Mythri. "Urinary Exosomal miRNA Signature of IgA Nephropathy: A Case-Control Study." Journal of the American Society of Nephrology 34, no. 11S (2023): 993. http://dx.doi.org/10.1681/asn.20233411s1993c.

Full text
APA, Harvard, Vancouver, ISO, and other styles
37

Nunez Nescolarde, Ana B., Mehran Piran, David J. Nikolic-Paterson, and Alexander N. Combes. "Hypoxia Triggers a Signature of Maladaptive Repair in Human Kidney Organoids." Journal of the American Society of Nephrology 33, no. 11S (2022): 421. http://dx.doi.org/10.1681/asn.20223311s1421b.

Full text
APA, Harvard, Vancouver, ISO, and other styles
38

Ginley, Brandon, Ricardo Melo ferreira, Ulysses G. Balis, et al. "Computational Segmentation of Glomeruli to Align Histomorphology With Spatial Transcriptomic Signature." Journal of the American Society of Nephrology 33, no. 11S (2022): 602. http://dx.doi.org/10.1681/asn.20223311s1602a.

Full text
APA, Harvard, Vancouver, ISO, and other styles
39

Assem, Assem, Ghoneimy Ghoneimy, El Nahas El Nahas, and Tantawy Tantawy. "A PROPOSED_IR_IMAGING SYSTEM FOR TRACKING OF MISSILE IR SIGNATURE IN AN ANTITANK-COUNTERMEASURES SCENAREO." International Conference on Aerospace Sciences and Aviation Technology 1, CONFERENCE (1985): 1–9. http://dx.doi.org/10.21608/asat.1985.26631.

Full text
APA, Harvard, Vancouver, ISO, and other styles
40

Attrill, G. D. R., L. K. Harra, L. van Driel-Gesztelyi, P. Démoulin, and J. P. Wülser. "Coronal “wave”: A signature of the mechanism making CMEs largescale in the low corona?" Astronomische Nachrichten 328, no. 8 (2007): 760–63. http://dx.doi.org/10.1002/asna.200710794.

Full text
APA, Harvard, Vancouver, ISO, and other styles
41

Holzwarth, V. "Spot signatures of a solar-type dynamo in close binary stars." Astronomische Nachrichten 325, no. 5 (2004): 408–12. http://dx.doi.org/10.1002/asna.200310241.

Full text
APA, Harvard, Vancouver, ISO, and other styles
42

Maity, Soumya, Christine P. Limonte, Erkka A. Valo, et al. "Metabolomic and Transcriptomic Reveal Signature of Citrate Homeostasis in Diabetic Kidney Disease." Journal of the American Society of Nephrology 34, no. 11S (2023): 37–38. http://dx.doi.org/10.1681/asn.20233411s137d.

Full text
APA, Harvard, Vancouver, ISO, and other styles
43

Perin, Laura, Hasmik Soloyan, Geremy Clair, et al. "The Spatially Resolved Transcriptome Signatures of Glomeruli in CKD." Journal of the American Society of Nephrology 33, no. 11S (2022): 163. http://dx.doi.org/10.1681/asn.20223311s1163a.

Full text
APA, Harvard, Vancouver, ISO, and other styles
44

Schlaffer, Stefan, Marco Chini, Denise Dettmering, and Wolfgang Wagner. "Mapping Wetlands in Zambia Using Seasonal Backscatter Signatures Derived from ENVISAT ASAR Time Series." Remote Sensing 8, no. 5 (2016): 402. http://dx.doi.org/10.3390/rs8050402.

Full text
APA, Harvard, Vancouver, ISO, and other styles
45

Starman, Terri Woods, and Shane Abbitt. "Distinguishing Poinsettia Cultivars and Evaluating Their Genetic Relationships using DNA Fingerprinting." HortScience 32, no. 3 (1997): 500A—500. http://dx.doi.org/10.21273/hortsci.32.3.500a.

Full text
Abstract:
The objective was to distinguish between cultivars and evaluate genetic relatedness of poinsettia (Euphorbia pulcherrima) using two methods of DNA fingerprinting—DNA Amplification Fingerprinting (DAF) and Arbitrary Signatures from Amplification Profiles (ASAP). Eleven red poinsettia cultivars were studied, including `Celebrate 2', `Darlyne', `Freedom Red', `Lilo', `Nutcracker Red', `Peterstar Red', `Petoy', `Red Sails', `Supjibi', `V-14 Glory', and `V-17 Angelika'. Amplification was with 10 octamer primers. Gels were visually scored for presence or absence of bands. The 10 primers generated 336 bands. The average number of bands (≈1000 bp) per primer was 34 ranging from 19 to 43. Thirty-one percent of bands were polymorphic and distinguished between each cultivar. The number of unique profiles varied from two to nine. Genetic relationships were evaluated by SAHN cluster analysis based on the distance estimator of Jaccard using the NTSYS-pc program (Numerical taxonomy and multivariate analysis system, version 1.8). The resulting dendrogram closely agreed with known pedigree data. ASAP analysis was used to further assess cultivar identification of two cultivars that were genetically and morphologically similar. Markers were found that separated `Nutcracker Red' and `Peterstar Red'. ASAP analysis separated cultivars within the Freedom series that DAF failed to distinguish. Two cultivars in the Freedom series, `Jingle Bells' and `Marble', were characterized from other cultivars in the series with ASAP.
APA, Harvard, Vancouver, ISO, and other styles
46

Zhu, Fengge, Xizhao Chen, Guangyan Cai, and Xiangmei Chen. "Compartment Specific Analysis of Leukocyte Trans-Endothelial Migration Molecular Signature in IgA Nephropathy." Journal of the American Society of Nephrology 33, no. 11S (2022): 785. http://dx.doi.org/10.1681/asn.20223311s1785a.

Full text
APA, Harvard, Vancouver, ISO, and other styles
47

Moon, Salina, Heather L. Donsky, Sylvia E. Rosas, Simon T. Dillon, and Monika A. Niewczas. "Cellular Proteomic Phenotypes Underlying Plasma Signature of 10-Year Risk of Kidney Failure." Journal of the American Society of Nephrology 31, no. 10S (2020): 336. http://dx.doi.org/10.1681/asn.20203110s1336b.

Full text
APA, Harvard, Vancouver, ISO, and other styles
48

EL-MAHLAWY, MOHAMED, and AHAMED SEDDIK. "DESIGN AND IMPLEMENTATION OF NEW AUTOMATIC TESTING SYSTEM FOR DIGITAL CIRCUITS BASED ON THE SIGNATURE ANALYSIS." International Conference on Aerospace Sciences and Aviation Technology 12, ASAT CONFERENCE (2007): 1–17. http://dx.doi.org/10.21608/asat.2007.23967.

Full text
APA, Harvard, Vancouver, ISO, and other styles
49

Aurass, H., A. Krüger, B. Rompolt та ін. "Radio signature and Hα limb features of the 1979 March 9 and 1982 July 9 flares". Astronomische Nachrichten: A Journal on all Fields of Astronomy 312, № 4 (1991): 245–57. http://dx.doi.org/10.1002/asna.2113120407.

Full text
APA, Harvard, Vancouver, ISO, and other styles
50

Albaaits, Aushof, and Bambang Eko Turisno. "Efektivitas Tanda Tangan Elektonik Pada Akta Yang Dibuat Oleh Notaris." Notarius 16, no. 3 (2022): 1741–55. http://dx.doi.org/10.14710/nts.v16i3.40263.

Full text
Abstract:
AbstractThe electornic system is used to explain the existence of an information system which the application of information technology based on telecommunicaton network and electronic media. A digital signature is a.n. electronically generated signature that functions the same as a regular signature on paper documents. Sudikno Mertokusumo gives the definition of a certificate as evidence that is signed, which contains events that form the basis of a thing or an engagement, which was made from the beginning intentionally for proof. As a public office holder, a notary has the authority to inaugurate various certificate as long as it is not under the authority of other officials. The theory of this research is the triadism law theory which was initiaded by Gustav Radburch, which contains the principle of justice, and the principle of legal certainty. The theory of legal protection was initiated by Roscue Pound which says “the law is a social engineering tool and the writing method used is normative juridical. The results of this study are that digital signature have benefits are authenticity (guaranteed exstence), integrity (cannot be modified), non-repudiation (cannot be denied its existence), and confidentiality.Keyword: digital signature; certificate; notaryAbstrakSistem elektronik berfungsi untuk menerangkan posisi sistem informasi sebagai implementasi dari teknologi informasi menggunakan media elektronik dan jaringan telekomunikasi. Tanda tangan elektronik dilakukan secara elektronik yang memiliki fungsi yang sama dengan tanda tangan biasa. Sudikno Mertokusumo menjelaskan bahwa akta merupakan alat bukti yang disertai dengan tanda tangan, sebagai bukti bahwa telah terjadi perikatan. Dalam menjalankan profesinya, Notaris berhak untuk mengesahkan segala akta kecuali akta yang menjadi wewenang lembaga lain. Studi ini menggunakan Teori Triadism Law dari Gustav Radburch, yang di dalamnya memuat asas kemanfaatan hukum, keadilan, dan kepastian hukum. Selain itu juga teori dari Roscue Pound mengenai perlindungan hukum yang menerangkan bahwa hukum adalah media rekayasa sosial, dimana metode penelitiannya yaitu yuridis normatif. Hasil studi ini menyimpulkan bahwa tanda tangan elektronik berguna sebagai authenticity (terjaminnya keberadaannya), integrity (tidak dapat dimodifikasi), non-repudiation (tidak dapat disangkal keberadaannya), dan confidentiality (bersifat rahasia).Kata kunci: tanda tangan elektronik; akta; notaris
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography