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Journal articles on the topic 'Asarone'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Kim, Hyojin, Jin Young Maeng, Dan Bi Lee, Kyung Hyun Kim, and Mi Sook Chung. "Antiviral Activities of Asarones and Rhizomes of Acorus gramineus on Murine Norovirus." Viruses 14, no. 10 (2022): 2228. http://dx.doi.org/10.3390/v14102228.

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Noroviruses (NVs) are a major cause of foodborne diseases worldwide. The rhizomes of Acorus gramineus (AGR) have been used as a traditional medicinal plant and a food additive. In this study, AGR and its bioactive components—α-asarone and β-asarone—showed significant antiviral activities against murine NV (MNV) with pre-treatment, with more than two log reductions in viral plaques. They also demonstrated strong inhibition on binding to A- and O-type saliva by the recombinant P domain derived from human NV (HuNV) GII.4. Both α- and β-asarones also inhibited the binding of the P domain to the re

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2

Banda, Kavyashree Vijayakumar, Gurupadayya Bannimath, Venkata Sairam Koganti та Vishwanathan Balasubramanya Iyer. "Gas Chromatographic Method for Analysis β-Asarone in Rhizome extracts of Acorus calamus and Their Microbiological Evaluation". Pharmaceutical Methods 7, № 2 (2016): 121–26. https://doi.org/10.5281/zenodo.14857105.

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Introduction: The aim of study was to develop a simple, sensitive and precise gas chromatographic method for the analysis of β-asaronein ethanolic, ethyl acetate, aqueous extracts from the rhizomes of Acorus calamus and validate according to current ICH guidelines. Followed by evaluation of antimicrobial activity of prepared extracts in comparison with penicillin disc. Methods: The β-asarone was one chief active constituent from the rhizomes of Acorus calamus. The ethanolic, ethyl acetate, aqueous extract of rhizomes was prepared and further evaluated for its antimicrobial activity a

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Hermes, Lena, Janis Römermann, Benedikt Cramer, and Melanie Esselen. "Phase II Metabolism of Asarone Isomers In Vitro and in Humans Using HPLC-MS/MS and HPLC-qToF/MS." Foods 10, no. 9 (2021): 2032. http://dx.doi.org/10.3390/foods10092032.

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(1) Background: Metabolism data of asarone isomers, in particular phase II, in vitro and in humans is limited so far. For the first time, phase II metabolites of asarone isomers were characterized and human kinetic as well as excretion data after oral intake of asarone-containing tea infusion was determined. (2) Methods: A high pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-qTOF-MS) approach was used to identify phase II metabolites using liver microsomes of different species and in human urine samples. For quantitation of the respective glucuroni

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4

Mikami, Masashi, Ohba Takuya, Yuta Yoshino та ін. "Acorus calamus extract and its component α-asarone attenuate murine hippocampal neuronal cell death induced by l-glutamate and tunicamycin". Bioscience, Biotechnology, and Biochemistry 85, № 3 (2021): 493–501. http://dx.doi.org/10.1093/bbb/zbaa071.

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ABSTRACT The Asian traditional medicinal plant Acorus calamus and its component α-asarone exhibited various biological activities, such as antiinflammation and antioxidant effects. In the present study, we investigated the in vitro effects of A. calamus extract and α-asarone on oxidative stress- and endoplasmic reticulum (ER) stress–induced cell death in hippocampal HT22 cells. A. calamus extract and α-asarone both significantly suppressed cell death induced by the oxidative stress inducer l-glutamate and ER stress inducer tunicamycin. A. calamus extract and α-asarone also significantly reduce

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5

Sumalatha, Munigela, Arigari Niranjana Kumar, Jonnala Kotesh Kumar, Kalavagunta Venkata Naga Satya Srinivas, Miriyala Vijay Kumar та Kommineni Vinutha. "Comparative studies on variation of β-Asarone composition in Acorus calamus Linn. by GC and HPLC". Journal of Medicinal and Aromatic Plant Sciences 46, № 1 (2024): 17–22. http://dx.doi.org/10.62029/jmaps.v46i1.sumalatha.

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The objective of this study was to assess the essential oil yields and chemical composition of the root of two varieties of Acorus calamus, namely the local and Jabalpur varieties. Gas chromatography (GC) and high-performance liquid chromatography (HPLC) analysis identified β-Asarone as the major chemical constituent. Notable findings revealed that fresh samples exhibited higher essential oil yield and β-Asarone content compared to various drying methods. Specifically, powdering the Jabalpur material resulted in a significant percentage (2.0%) of essential oils, with negligible variations obse

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Vidya C S and Arehally M Mahlakshmi. "Neuroprotective role of Beta-asarone: A review." International Journal of Research in Pharmaceutical Sciences 12, no. 3 (2021): 1908–14. http://dx.doi.org/10.26452/ijrps.v12i3.4792.

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Acorus calamus (Acoraceae) also known as sweet flag in Indian traditional medicine is generally used for treatment of various ailments like cough, fever, bronchitis, inflammation, depression, tumours, haemorrhoids, skin diseases, insomnia, hysteria, epilepsy, and loss of memory. Asarone is a chemical compound of the phenylpropanoid class found in plants such as Acorus and Asarum. There are two isomers, α (trans) and β (cis). Alpha-asarone is potentially toxic compared to beta-asarone and hence pharmacological elucidation of beta-asarone is wide. Beta-asarone due to its blood brain barrier cros

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7

Tao, Heyun, Xuelian Ding, Jian Wu та ін. "β-Asarone Increases Chemosensitivity by Inhibiting Tumor Glycolysis in Gastric Cancer". Evidence-Based Complementary and Alternative Medicine 2020 (10 квітня 2020): 1–13. http://dx.doi.org/10.1155/2020/6981520.

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β-asarone is the main active ingredient of the Chinese herb Rhizoma Acori Tatarinowii, which exhibits a wide range of biological activities. It was confirmed to be an efficient cytotoxic agent against gastroenteric cancer cells. However, the exact mechanism of β-asarone in gastric cancer (GC) remains to be elucidated. The present study showed the inhibitory effect of β-asarone on three types of different differentiation stage GC cell lines (MGC803, SGC7901, and MKN74) in a dose-dependent manner. Meanwhile, the synergistic sensitivity of β-asarone and cisplatin was confirmed by using the median

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8

Wang, Ran, Yong Fang, Wunan Che, Qinghe Zhang, Jinda Wang та Chen Luo. "The Toxicity, Sublethal Effects, and Biochemical Mechanism of β-Asarone, a Potential Plant-Derived Insecticide, against Bemisia tabaci". International Journal of Molecular Sciences 23, № 18 (2022): 10462. http://dx.doi.org/10.3390/ijms231810462.

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Bemisia tabaci is a threat to agriculture worldwide because of its potential to cause devastating damage to various crops. β-asarone is a bioactive pesticidal chemical originating from Acorus calamus (or “Sweet Flag”) plants, and it displays significant lethal effects against insect pests. In this study, we established a baseline of susceptibility to β-asarone from China and patterns of cross-resistance to other popular insecticides. We found that all the 12 field-collected B. tabaci populations exhibited high susceptibility to β-asarone, and there was no cross-resistance detected for other te

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9

Yang, Yuanxiao, Ling Xuan, Hongshu Chen та ін. "Neuroprotective Effects and Mechanism of β-Asarone against Aβ1–42-Induced Injury in Astrocytes". Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/8516518.

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Emerging evidence suggests that activated astrocytes play important roles in AD, and β-asarone, a major component of Acorus tatarinowii Schott, was shown to be a potential therapeutic candidate for AD. While our previous study found that β-asarone could improve the cognitive function of rats hippocampally injected with Aβ, the effects of β-asarone on astrocytes remain unclear, and this study aimed to investigate these effects. A rat model of Aβ1–42 (10 μg) was established, and the rats were intragastrically treated with β-asarone at doses of 10, 20, and 30 mg/kg or donepezil at a dose of 0.75

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10

Shi, Hai-Xia, Jiajun Yang, Tao Yang, et al. "Alpha-Asarone Protects Endothelial Cells from Injury by Angiotensin II." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/682041.

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α-Asarone is the major therapeutical constituent ofAcorus tatarinowiiSchott. In this study, the potential protective effects ofα-asarone against endothelial cell injury induced by angiotensin II were investigatedin vitro. The EA.hy926 cell line derived from human umbilical vein endothelial cells was pretreated withα-asarone (10, 50, 100 µmol/L) for 1 h, followed by coincubation with Ang II (0.1 µmol/L) for 24 h. Intracellular nitric oxide (NO) and reactive oxygen species (ROS) were detected by fluorescent dyes, and phosphorylation of endothelial nitric oxide synthase (eNOS) atSer1177was determ

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11

Kafle, Lekhnath, and Cheng-Jen Shih. "Insecticidal Activities of Compounds from Sweet Flag (Acorus Calamus) against Red Imported Fire Ants Solenopsis invicta (Hymenoptera: Formicidae)." Sociobiology 64, no. 4 (2017): 398. http://dx.doi.org/10.13102/sociobiology.v64i4.1867.

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Due to public health and environmental issues, alternatives of synthetic pesticides have been researched for a long time. We also evaluated the toxicity and repellency of the sweet flag (Acorus calamus) powder and two bioactive compounds (α-asarone and β-asarone) against workers of the red imported fire ant (RIFA), Solenopsis invicta under laboratory conditions. Sweet flag powder applied at 1 mg/cm2 or more provided 100% ant mortality within 18 hours, and repelled almost 97% of ants within one hour. Β-asarone was the faster acting compound against RIFA compared to α-asarone and sweet flag powd

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12

Bindu, M. B., Linu Sam, and Amrutha R. "Potential Energy Distribution Study Of Beta Asarone and its Vibrational Spectrum and Force Constants." Journal of University of Shanghai for Science and Technology 23, no. 09 (2021): 959–66. http://dx.doi.org/10.51201/jusst/21/09635.

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The PED assignments are analysed for the title molecule. The Force Constants and Reduced masses are presented for reference. Vibrational assignments are made to the title molecule Beta Asarone. .The analysis of Vibrational Assignments is done with an intention to deduce the various properties of Beta Asarone that should aid in analysing the reported toxicity of Beta Asarone.

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13

Haupenthal, S., K. Berg, M. Gründken, et al. "In vitro genotoxicity of carcinogenic asarone isomers." Food & Function 8, no. 3 (2017): 1227–34. http://dx.doi.org/10.1039/c6fo01701k.

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14

Jiang, Lan, та Xiangnan Hu. "Positive Effect of α-Asaronol on the Incidence of Post-Stroke Epilepsy for Rat with Cerebral Ischemia-Reperfusion Injury". Molecules 27, № 6 (2022): 1984. http://dx.doi.org/10.3390/molecules27061984.

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In the present study, we confirmed that α-asaronol, which is a product of the active metabolites of alpha Asarone, did not affect n-butylphthalide efficacy when n-butylphthalide and α-asaronol were co-administered to rats with cerebral ischemia-reperfusion injury. Our research revealed that the co-administration of α-asaronol and n-butylphthalide could further improve neurological function, reduce brain infarct volume, increase the number of Nissl bodies, and decrease the ratios of apoptotic cells and the expression of the caspase-3 protein for cerebral ischemia-reperfusion injury model compar

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15

Cai, Jingwen, Ming Cai, Wenwen Xia, Lanlan Jiang, Hang Song та Xiangtao Chen. "Explore the Mechanism of β-Asarone on Improving Cognitive Dysfunction in Rats with Diabetic Encephalopathy". Journal of Alzheimer's Disease Reports 6, № 1 (2022): 195–206. http://dx.doi.org/10.3233/adr-220001.

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Background: The number of people with diabetes is increasing, and many patients have significantly impaired cognitive function. For patients with diabetic encephalopathy (DE), simply lowering blood sugar does not improve learning and memory. Studies have shown that β-asarone can significantly improve cognitive impairment in patients with DE, but the specific mechanism of action is unclear. Objective: This experiment hopes to use a variety of experimental methods to clarify the protective effect and mechanism of β-asarone on brain neurons during the development of DE disease. Methods: A high-su

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16

Dyas, Riyadh Aqilsya Amaryl, Bambang Wijianto, and Hariyanto IH. "Docking studies for screening antibacterial compounds of Red Jeringau (Acorus calamus L.) using Shigella flexneri protein as a model system." Acta Chimica Asiana 6, no. 2 (2023): 343–50. http://dx.doi.org/10.29303/aca.v6i2.161.

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Alpha (a) and beta (β) asarone were identified as the main compounds of red Jeringau (Acorus calamus L.) and had antimicrobial properties. This study aimed to know these two compounds' antibacterial mechanism and toxicity prediction against the PBP 2 protein and 50S Ribosomal Protein of Shigella flexneri. Molecular docking protocol using PyRx device was performed with Exhaustiveness value= 106, grid x=38.738375, y=112.645792, z=46.926417 for PBP2, and grid x=71.721251, y=47.551601, z=9.663173 for 50S Ribosomal Protein. The molecular docking results on the α -Asarone compound obtained an affini

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17

Widmer, Valeria, Anne Schibli та Eike Reich. "Quantitative Determination of β-Asarone in Calamus by High-Performance Thin-Layer Chromatography". Journal of AOAC INTERNATIONAL 88, № 5 (2005): 1562–67. http://dx.doi.org/10.1093/jaoac/88.5.1562.

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Abstract A quantitative high-performance thin-layer chromatographic method for determination of β-asarone in Calamus rhizome was developed and validated. The method is suitable for proper identification of Acorus calamus. Through the use of caffeine-modified silica gel as the stationary phase and toluene–ethyl acetate (93 + 7, v/v) as the mobile phase, β-asarone is baseline separated from its isomer α-asarone. Scanning densitometry with absorption measurement at 313 nm allows specific, accurate, and precise quantification of β-asarone. The working range of 40 to 200 ng absolute of the target s

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18

S., Asha Devi, та Babu S. "In vitro genotoxic study of β-asarone in human peripheral blood lymphocytes". Journal of Indian Chemical Society Vol. 92, Apr 2015 (2015): 549–51. https://doi.org/10.5281/zenodo.5596230.

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School of Biosciences and Technology, VIT University, Vellore-632 014, Tamilnadu, India <em>E-mail</em> : ashaselvaraj74@gmail.com Present study was carried out to ascertain whether β-asarone, a constituent of herbal medicinal oil exert genotoxic effects in human peripheral blood lymphocytes (PBL). For this study human PBL from six healthy human male volunteers were treated with 208 µg/ml of β-asarone and leukocyte binucleate assay was performed. The results obtained suggest that β-asarone did not increase the incidence of micronucleated cells in PBL but mitomycin-C used a

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19

Lee, Kim, Yeo, et al. "Anti-Amyloidogenic Effects of Asarone Derivatives From Perilla frutescens Leaves against Beta-Amyloid Aggregation and Nitric Oxide Production." Molecules 24, no. 23 (2019): 4297. http://dx.doi.org/10.3390/molecules24234297.

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Alzheimer’s disease (AD) is a progressive, neurodegenerative brain disorder associated with loss of memory and cognitive function. Beta-amyloid (Aβ) aggregates, in particular, are known to be highly neurotoxic and lead to neurodegeneration. Therefore, blockade or reduction of Aβ aggregation is a promising therapeutic approach in AD. We have previously reported an inhibitory effect of the methanol extract of Perilla frutescens (L.) Britton (Lamiaceae) and its hexane fraction on Aβ aggregation. Here, the hexane fraction of P. frutescens was subjected to diverse column chromatography based on act

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Sun, Dazhong, Lulu Wu, Siyuan Lan, Xiangfeng Chi та Zhibing Wu. "β-asarone induces viability and angiogenesis and suppresses apoptosis of human vascular endothelial cells after ischemic stroke by upregulating vascular endothelial growth factor A". PeerJ 12 (27 червня 2024): e17534. http://dx.doi.org/10.7717/peerj.17534.

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Ischemic stroke (IS) is a disease with a high mortality and disability rate worldwide, and its incidence is increasing per year. Angiogenesis after IS improves blood supply to ischemic areas, accelerating neurological recovery. β-asarone has been reported to exhibit a significant protective effect against hypoxia injury. The ability of β-asarone to improve IS injury by inducing angiogenesis has not been distinctly clarified. The experimental rats were induced with middle cerebral artery occlusion (MCAO), and oxygen-glucose deprivation (OGD) model cells were constructed using human microvascula

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Park, Cheol, Hee-Jae Cha, Hyun Hwangbo та ін. "β-Asarone Alleviates High-Glucose-Induced Oxidative Damage via Inhibition of ROS Generation and Inactivation of the NF-κB/NLRP3 Inflammasome Pathway in Human Retinal Pigment Epithelial Cells". Antioxidants 12, № 7 (2023): 1410. http://dx.doi.org/10.3390/antiox12071410.

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Diabetic retinopathy (DR) is the leading cause of vision loss and a major complication of diabetes. Hyperglycemia-induced accumulation of reactive oxygen species (ROS) is an important risk factor for DR. β-asarone, a major component of volatile oil extracted from Acori graminei Rhizoma, exerts antioxidant effects; however, its efficacy in DR remains unknown. In this study, we investigated whether β-asarone inhibits high-glucose (HG)-induced oxidative damage in human retinal pigment epithelial (RPE) ARPE-19 cells. We found that β-asarone significantly alleviated cytotoxicity, apoptosis, and DNA

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Tathe, Prafulla R., Rakesh Kumar Jat, Amjadkhan Pathan та Kailas Biyani. "Α-Asarone Protects CCL4 Induced Hepatotoxicity in Experimental Rats by inhibiting oxidative stress and cytokines". Journal of Drug Delivery and Therapeutics 12, № 3 (2022): 103–7. http://dx.doi.org/10.22270/jddt.v12i3.5335.

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The present study aimed to study the protective effect of alpha- Asarone in CCL4-induced hepatotoxicity in experimental rats. The rats were randomly divided into 5 groups each containing six rats. CCL4 was given at a dosage of 0.5 mL/kg to produce hepatotoxicity, and serum AST, ALT, total bilirubin, and albumin, as well as hepatic hydroxyproline (HP), reduced glutathione (GSH), and malondialdehyde (MDA), cytokines, and NO, were assessed. CCL4 treatment resulted in a decrease in body weight and an increase in liver weight in rats, while treatment with α- Asarone resulted in normal body and live

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Kumar, Ravendra, Om Prakash, Anil K. Pant, Subrata K. Hore, Chandan S. Chanotiya та Chandra S. Mathela. "Compositional Variations and Anthelmentic Activity of Essential Oils from Rhizomes of Different Wild Populations of Acorus Calamus L. and its Major Component, β-Asarone". Natural Product Communications 4, № 2 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400222.

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Hydro-distilled essential oils from Acorus calamus rhizomes collected from six different geographical zones in the northwest Himalayan region of Uttarakhand have been analyzed by GC and GC/MS. All the oils differed in their qualitative and quantitative make up, although β-asarone was the major constituent of all of them. The essential oils and the isolated β-asarone were screened for anthelmintic activity using contractility of Ascaridia galli. β-Asarone, in particular, showed potent activity with IC50 values of 75.4 ± 61.8 ng/mL.

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Meng, Xue, Xinfeng Zhao, Shixiang Wang, et al. "Simultaneous Determination of Volatile Constituents fromAcorus tatarinowiiSchott in Rat Plasma by Gas Chromatography-Mass Spectrometry with Selective Ion Monitoring and Application in Pharmacokinetic Study." Journal of Analytical Methods in Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/949830.

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A sensitive and specific gas chromatographic-mass spectrometry with selected ion monitoring (GC-MS/SIM) method has been developed for simultaneous identification and quantification ofα-asarone,β-asarone, and methyl eugenol ofAcorus tatarinowiiSchott in rat plasma. Chromatographic separation was performed on a Restek Rxi-5MS capillary column (30 m × 0.32 mm × 0.25 μm), using 1-naphthol as internal standard (IS). MS detection of these compounds and IS was performed atm/z178, 208, 208, and 144. Intra- and interday precisions of all compounds of interest were less than 10%. The recoveries are situ

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Rahul, Kashyap1 Shivaji Patel2 Chandraprabha Dewangan*3 GyaneshKumar Sahu4. "Acorus Calamus: An Ancient Remedy with Modern Medicinal Applications." International Journal of Scientific Research and Technology 2, no. 2 (2025): 140–48. https://doi.org/10.5281/zenodo.14892736.

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The aim of the paper is provided information regarding incredible medicinal herb AcorusCalamus and its extract has various medicinal benefits like Anti diabetic activity, anti hypertensive effect, cytotoxic effect , immunosuppressive activity , antifungal activity , analgesic and anticonvulsant effect, bronchodilatory activity , licicidal activity, wound healing activity, coronary vasodilator effect, anti-cancer activity.The phytochemical constituent present in extract of oil are a-asarone, b-asarone, c-asarone, calamine, calamenenol, calameone, a-pinene,b-pinene, camphene, p-cymene, eugenyl a

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Wang, Aiyu, Yun Zhou, Xiaochen Fu та ін. "Structural Derivatives of β-Asarone from Acorus calamus Linn. as Insecticide Candidates and the Insecticidal Mechanism Against Small Brown Planthopper". Agronomy 14, № 10 (2024): 2420. http://dx.doi.org/10.3390/agronomy14102420.

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The small brown planthopper (SBPH), Laodelphax striatellus (Fallén) (Hemiptera: Delphacidae), is an increasing threat to Gramineae crops, posing significant risks to both the environment and food safety. β-asarone, as a promising green alternative to chemical insecticides, possesses wide application prospects in the crop protection field. To enhance the insecticidal activity of β-asarone, a series of derivatives were prepared through an active substructure splicing strategy, and their insecticidal activities against SBPH were evaluated. Among the 7 commercial compounds with chemical structures

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Khanal, Sumnath, Devi Prasad Bhandari, Laxman Bhandari, and Achyut Adhikari. "Chemical profiling and antioxidant activities of essential oil from rhizomes of Acorus calamus L." BIBECHANA 17 (January 1, 2020): 89–95. http://dx.doi.org/10.3126/bibechana.v17i0.25201.

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Background and Aims: Acorus calamus L. is an indigenous herb in Nepal. It belongs to family Acoraceae and grows in wet land with scented rhizomes. It is also known as Sweet flag in English and commonly as Bojho in Nepal. The present investigation reveals the chemical compositions and antioxidant activity of rhizome essential oil of A. calamus. Methods: Essential oil of rhizomes of Acorus calamus L. from Kaski district, Nepal was extracted by hydrodistillation method and volatile constituents were analyzed Gas chromatography-Mass spectrometry. The antioxidant potential of essential oil was anal

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Balakrishnan, Rengasamy, Duk-Yeon Cho, In-Su Kim, Sang-Ho Seol та Dong-Kug Choi. "Molecular Mechanisms and Therapeutic Potential of α- and β-Asarone in the Treatment of Neurological Disorders". Antioxidants 11, № 2 (2022): 281. http://dx.doi.org/10.3390/antiox11020281.

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Neurological disorders are important causes of morbidity and mortality around the world. The increasing prevalence of neurological disorders, associated with an aging population, has intensified the societal burden associated with these diseases, for which no effective treatment strategies currently exist. Therefore, the identification and development of novel therapeutic approaches, able to halt or reverse neuronal loss by targeting the underlying causal factors that lead to neurodegeneration and neuronal cell death, are urgently necessary. Plants and other natural products have been explored

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Vargas, R. R., V. L. Pardini та H. Viertler. "Electrosynthesis of γ-asarone". Tetrahedron Letters 30, № 31 (1989): 4037–40. http://dx.doi.org/10.1016/s0040-4039(00)99315-8.

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Nascimento, Gleydiane Marcelle da Silva, Aline Aparecida Saldanha, Mariana de Lima Nascimento, and Whocely Victor de Castro. "Phenylpropanoids in species of plants of the Duguetia genus: A review." Research, Society and Development 11, no. 4 (2022): e18511427266. http://dx.doi.org/10.33448/rsd-v11i4.27266.

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The genus Duguetia encompasses 93 species, 63 of which are distributed in Brazil. However, only ten species had their chemical and biological profiles investigated so far. Although the alkaloids are the class of phytocompounds most studied, the interest in the phenylpropanoids is growing since distinct biological activities have been attributed to these derivatives lately. This review gathered studies describing the phytochemical distribution, methods of extraction, and biological activities of the phenylpropanoid from Duguetia species. It was evidenced that nonpolar solvents were able to prov

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Lee, Yeon-Suk, Junheon Kim, Sang-Gil Lee, Sang-Chul Shin, and Il-Kwon Park. "Fumigant Antifungal Activity of Essential Oil Components from Acorus gramineus against Three Phytopathogenic Fungi." Zeitschrift für Naturforschung C 63, no. 7-8 (2008): 503–6. http://dx.doi.org/10.1515/znc-2008-7-806.

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Analysis by gas chromatography-mass spectrometry led to the identification of 26 compounds in Acorus gramineus essential oil. The antifungal activity of the identified compounds was tested singularly by using standard compounds. Allyl isothiocyanate and cis-asarone showed inhibition rates of 100% against P. cactorum at 28 mg/l air. In a test with C. parasitica and F. circinatum, allyl isothiocyante and cis-asarone showed moderate activity at 28 mg/l air.

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Yang, Fan, Hongyu Duan, Nannan Ye та ін. "β-Asarone Protects PC12 Cells Against Hypoxia-Induced Injury Via Negatively Regulating RPPH1/MiR-542-3p/DEDD2 Axis". Cell Transplantation 31 (січень 2022): 096368972210793. http://dx.doi.org/10.1177/09636897221079336.

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Hypoxic injury to the brain is very intricate under the control of biochemical reactions induced by various factors and mechanisms. Long non-coding RNAs (lncRNAs) have already been revealed to affect pathological processes in the nervous system of different degrees. This research aimed to investigate the mechanisms implicated in hypoxic brain injury. β-Asarone mitigated the decrease of cell viability, superoxide dismutase activity, and mitochondrial membrane potential, as well as the increase of cell apoptosis, lactate dehydrogenase release, malondialdehyde content, and reactive oxidative spec

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Prabha, S., and J. Kumar. "Gas Chromatographic and Mass Spectroscopic (GC-MS) Analysis of Rhizome of Acorus Calamus Linn. for Identification of Potent Antimicrobial Bio-active Compounds." Journal of Scientific Research 13, no. 1 (2021): 263–73. http://dx.doi.org/10.3329/jsr.v13i1.48452.

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Acorus calamus Linn. has wide applications as a herbal medicine since its roots, leaves and rhizome exhibit antimicrobial and insecticidal activities. The objective of this study was to identify some compounds in Acorus calamus Linn., which may be responsible for its antimicrobial activity. Gas Chromatography-Mass Spectroscopy (GC-MS) analysis, for investigation of the compounds present, of the petroleum ether extract of Acorus calamus Linn. rhizome suggested presence of five compounds (which showed close match with those of the GC-MS database main library of Novocatalyz) viz., spiro [2,4,5,6,

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Liu, Xin Chao, Qiyong Liu, Xu Bo Chen, Qi Zhi Liu, and Zhi Long Liu. "Larvicidal activity of the essential oil of Youngia japonica aerial parts and its constituents against Aedes albopictus." Zeitschrift für Naturforschung C 70, no. 1-2 (2015): 1–6. http://dx.doi.org/10.1515/znc-2014-4074.

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Abstract The aim of this study was to evaluate the larvicidal activity of the essential oil of Youngia japonica aerial parts against the larvae of Aedes albopictus and to isolate any active compounds from the oil. Gas chromatography-mass spectrometry (GC-MS) analyses revealed the presence of 31 compounds, with menthol (23.53%), α-asarone (21.54%), 1,8-cineole (5.36%), and caryophyllene (4.45%) as the major constituents. Bioactivity-directed chromatographic separation of the oil led to the isolation of menthol and α-asarone as active compounds. The essential oil of Y. japonica exhibited larvici

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Prabha, S., and J. Kumar. "Gas Chromatographic and Mass Spectroscopic (GC-MS) Analysis of Rhizome of Acorus Calamus Linn. for Identification of Potent Antimicrobial Bio-active Compounds." Journal of Scientific Research 13, no. 1 (2021): 263–73. http://dx.doi.org/10.3329/jsr.v13i1.48452.

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Acorus calamus Linn. has wide applications as a herbal medicine since its roots, leaves and rhizome exhibit antimicrobial and insecticidal activities. The objective of this study was to identify some compounds in Acorus calamus Linn., which may be responsible for its antimicrobial activity. Gas Chromatography-Mass Spectroscopy (GC-MS) analysis, for investigation of the compounds present, of the petroleum ether extract of Acorus calamus Linn. rhizome suggested presence of five compounds (which showed close match with those of the GC-MS database main library of Novocatalyz) viz., spiro [2,4,5,6,

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Shenvi, Suvarna, Latha Diwakar та G. Chandrasekara Reddy. "Nitro Derivatives of Naturally Occurring β-Asarone and Their Anticancer Activity". International Journal of Medicinal Chemistry 2014 (1 жовтня 2014): 1–5. http://dx.doi.org/10.1155/2014/835485.

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β-Asarone (2, 4, 5-trimethoxy-(Z)-1-propenylbenzene) was obtained from Acorus calamus. Nitration of β-asarone with AgNO2/I2 in ether yielded 1-(2, 4, 5-trimethoxy phenyl)-2-nitropropene (1) but with NaNO2/I2 in ethylene glycol obtained 1-(2, 4, 5-trimethoxy phenyl)-1-nitropropene (2). Compound 2 was prepared for the first time and characterized using IR, 1H-NMR, 13C-NMR, and GC-MS spectra and it was converted into 1-(2, 4, 5-trimethoxy) phenyl-1-propanone (3) using modified Nef reaction. Based on 1D NOESY experiments, compounds 1 and 2 have been assigned E configuration. Compounds 1 and 2 were

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Satyal, Prabodh, Prajwal Paudel, Ambika Poudel, et al. "Chemical Compositions, Phytotoxicity, and Biological Activities of Acorus Calamus Essential Oils from Nepal." Natural Product Communications 8, no. 8 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800839.

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Four essential oils from the leaf (P23) and rhizomes (P19, P22, P24) of Acorus calamus L., collected from various parts of Nepal, were obtained by hydrodistillation and analyzed by GC-MS. From a total of 61 peaks, 57 compounds were identified among the four essential oils accounting for 94.3%, 96.2%, 97.6%, and 94.1% of the oils, respectively. All of the essential oils were dominated by ( Z)-asarone (78.1%–86.9%). The essential oils also contained ( E)-asarone (1.9%–9.9%) and small amounts of γ-asarone (2.0–2.3%), ( Z)-methyl isoeugenol (1.5–2.0%), and linalool (0.2–4.3%). Allelopathic testing

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Cabrera, Elvia V., Kelly P. Marrugo, José G. Ortega, Ajoy K. Banerjee та Jennifer L. Sanchez. "Total Synthesis of α-Asarone". Organic Preparations and Procedures International 44, № 5 (2012): 455–59. http://dx.doi.org/10.1080/00304948.2012.715061.

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Asha Devi, S., A. L. Mali, M. A. Rahee, and E. D. S. Belinda. "Antioxidant Properties of Alpha Asarone." Asian Journal of Biochemistry 9, no. 2 (2014): 107–13. http://dx.doi.org/10.3923/ajb.2014.107.113.

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Karwicka, Ewa, Jadwiga Marczewska, Elżbieta Anuszewska, Bożena Łozowicka та Zdzisław Chilmonczyk. "Genotoxicity of α-asarone analogues". Bioorganic & Medicinal Chemistry 16, № 11 (2008): 6069–74. http://dx.doi.org/10.1016/j.bmc.2008.04.049.

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Lander, V., and P. Schreier. "Light-induced transformation of asarone." Flavour and Fragrance Journal 6, no. 1 (1991): 21–28. http://dx.doi.org/10.1002/ffj.2730060104.

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Do Thi, Thuy-Van, Ngoc-Linh Nguyen, and Anh-Hung Nguyen. "Chemical components and anti-acetylcholinesterase activity of Piper lolot leaves oil." HPU2 Journal of Science Natural Sciences and Technology 2, no. 2 (2023): 41–47. http://dx.doi.org/10.56764/hpu2.jos.2023.2.2.41-47.

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Essential oil of Piper lolot leaves in Quang Nam-Da Nang do obtain via the steam distillation method with oil collection efficiency reaching 0.68%. The chemical components of the essential oil from Piper lolot leaves in Quang Nam-Da Nang are determined via the GC-MS method that includes 20 compositions (99.97%), among which the main compositions are myristicin (72.70%), asarone (5.16%), β-bisabolene (3.59%), γ-asarone (3.52%), caryophyllene (2.63%), and α-copaene (1.93%). The essential oil of Piper lolot leaves in Quang Nam-Da Nang also showed potent anti-acetylcholinesterase activity with IC5

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Joshi, Bhawani Datt, та Paras Nath Chaudhary. "Molecular Structure, MESP, HOMO-LUMO, and Vibrational Analysis of β-Asarone Using Density Functional Theory". Kathmandu University Journal of Science, Engineering and Technology 9, № 2 (2013): 1–14. http://dx.doi.org/10.3126/kuset.v9i2.63714.

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Medicinal Plants have always had an important place in the therapeutic armoury of mankind. β-Asarone mainly found in Acorus calamus L., Araceae, is one of the main bioactive constituents of its essential oil. In this communication, we have presented the geometry optimization, molecular electrostatic potential surface, frontier orbital energy gap and vibrational wavenumbers of β-asarone using density functional theory (DFT/B3LYP) method employing 6-311G(d,p) basis set. A complete vibrational assignment has been done on the basis of an isolated molecule. The electronic transition has been calcul

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Díaz, Francisco, Leticia Contreras, Rosa Flores та ін. "AN EFFICIENT SYNTHESIS OF α-ASARONE". Organic Preparations and Procedures International 23, № 2 (1991): 133–38. http://dx.doi.org/10.1080/00304949109458299.

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Cartus, Alexander, Simone Stegmüller, and Dieter Schrenk. "Phase-I-metabolism of asarone-isomers." Toxicology Letters 229 (September 2014): S173. http://dx.doi.org/10.1016/j.toxlet.2014.06.592.

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Haupenthal, S., and M. Esselen. "In vitro genotoxicity of asarone isomers." Toxicology Letters 258 (September 2016): S190. http://dx.doi.org/10.1016/j.toxlet.2016.06.1699.

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Cartus, Alexander T., Simone Stegmüller, Nadine Simson та ін. "Hepatic Metabolism of Carcinogenic β-Asarone". Chemical Research in Toxicology 28, № 9 (2015): 1760–73. http://dx.doi.org/10.1021/acs.chemrestox.5b00223.

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Yabiku, Helena Yuco, Seizi Oga, Franco Lajolo та Heloisa Andrighetti. "Efeitos tóxicos de α e β-asaronas e do óleo de cálamo em camundongos, embriões de galinha e mutagenicidade em Salmonella typhimurium". Revista do Instituto Adolfo Lutz 45, № 1-2 (1985): 1–12. http://dx.doi.org/10.53393/rial.1985.45.36843.

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Foram verificadas as DL50 do óleo de cálamo de variedades diferentes, assim como os seus componentes ativos a e B3-asaronas em camundongos, por via intraperitoneal. A DL50 do óleo de cálamo, variedade indiana, foi de 154,5 mgv'kg, a da ,B-asarona, de 184,0 mg/kg e a da a-asarona, de 226,0 mgv'kg. Para variedade européia e para o extrato oleoso isento de asaro nas, em virtude de suas baixas toxicidades agudas, não foi possível a determinação dos valores de DL50. O estudo da toxicidade em embriões de galinha para verificar eventual atividade teratogênica foi feito também para os óleos de diferen

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Ch, Venkat Narsimhaji, Kanakrajan Vijayakumari Rakhesh, Ilavarasan Raju та ін. "Impact of season on phytochemistry with special reference to β-Asarone content, extract yield and Pharmacognostic parameter in rhizome of Acorus calamus L." International Journal of Ayurvedic Medicine 15, № 3 (2024): 744–48. http://dx.doi.org/10.47552/ijam.v15i3.4806.

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Demand of medicinal plants is growing exponentially due to its extensive use in nutraceutical, cosmeceutical and pharmaceutical industries. The major problem is the variation in quality and quantity of phytoconstituents with the collection of medicinal plants in each batch. Though, the quality and quantity of phytoconstituents in plants are influenced by various factors, chief among them is seasonal variation. Rhizome of Acorus calamus L. is used in treatment of neurological disorder specially in children. The Ayurvedic system of medicine believes blends of constituent imparts therapeutic acti

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He, Xirui, Yajun Bai, Min Zeng та ін. "Anticonvulsant activities of α-asaronol (( E )-3′-hydroxyasarone), an active constituent derived from α-asarone". Pharmacological Reports 70, № 1 (2018): 69–74. http://dx.doi.org/10.1016/j.pharep.2017.08.004.

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