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Journal articles on the topic 'Ascaridole'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 June 2025

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1

Chen, Jianhan, Rohen Prinsloo та Xiongwei Ni. "A Kinetic Study of a Photo-Oxidation Reaction between α-Terpinene and Singlet Oxygen in a Novel Oscillatory Baffled Photo Reactor". Technologies 12, № 3 (2024): 29. http://dx.doi.org/10.3390/technologies12030029.

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By planting LEDs on the surfaces of orifice baffles, a novel batch oscillatory baffled photoreactor (OBPR) together with polymer-supported Rose Bengal (Ps-RB) beads are here used to investigate the reaction kinetics of a photo-oxidation reaction between α-terpinene and singlet oxygen (1O2). In the mode of NMR data analysis that is widely used for this reaction, α-terpinene and ascaridole are treated as a reaction pair, assuming kinetically singlet oxygen is in excess or constant. We have, for the first time, here examined the validity of the method, discovered that increasing α-terpinene initially leads to an increase in ascaridole, indicating that the supply of singlet oxygen is in excess. Applying a kinetic analysis, a pseudo-first-order reaction kinetics is confirmed, supporting this assumption. We have subsequently initiated a methodology of estimating the 1O2 concentrations based on the proportionality of ascaridole concentrations with respect to its maximum under these conditions. With the help of the estimated singlet oxygen data, the efficiency of 1O2 utilization and the photo efficiency of converting molecular oxygen to 1O2 are further proposed and evaluated. We have also identified conditions under which a further increase in α-terpinene has caused decreases in ascaridole, implying kinetically that 1O2 has now become a limiting reagent, and the method of treating α-terpinene and ascaridole as a reaction pair in the data analysis would no longer be valid under those conditions.

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2

Bai, Chuan Qi, Zhi Long Liu, and Qi Zhi Liu. "Nematicidal Constituents from the Essential Oil ofChenopodium AmbrosioidesAerial Parts." E-Journal of Chemistry 8, s1 (2011): S143—S148. http://dx.doi.org/10.1155/2011/470862.

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Essential oil of Chinese medicinal herb,Chenopodium ambrosioidesaerial parts was found to possess nematicidal activity against the root-knot nematodes,Meloidogyne incognita. The essential oil ofC. ambrosioideswas obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). A total of 27 components of the essential oil were identified. The principal compounds inC. ambrosioidesessential oil were (Z)-ascaridole (27.27%),ρ-cymene (19.05%), isoascaridole (14.75%),α-pinene (6.33%) andα-terpinene (5.12%). Bioactivity-guided chromatographic separation of the essential oil on repeated silica gel columns led to isolate three volatile components ((Z)-ascaridole,ρ-cymene and isoascaridole) from the essential oil. The essential oil and (Z)-ascaridole exhibited strong nematicidal activity againstM. incognitawith LC50values of 49.55 μg/mL and 32.79 μg/mL, respectively.ρ-Cymene and isoascaridole also possessed nematicidal activity againstM. incognitawith LC50values of 435.89 μg/mL and 1323.51 μg/mL, respectively but weaker than the crude essential oil.

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3

Ávila-Blanco, Manuel Enrique, Martín Gerardo Rodríguez, José Luis Moreno Duque, Martin Muñoz-Ortega, and Javier Ventura-Juárez. "Amoebicidal Activity of Essential Oil ofDysphania ambrosioides(L.) Mosyakin & Clemants in an Amoebic Liver Abscess Hamster Model." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/930208.

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Amebiasis is a parasitic disease that extends worldwide and is a public health problem in developing countries. Metronidazole is the drug recommended in the treatment of amebiasis, but its contralateral effects and lack of continuity of treatment induce low efficiency, coupled with the appearance of resistant amoebic strains. Therefore, the search of new compounds with amoebicidal activity is urgent and important. In this study, we evaluated the in vitro and in vivo antiamoebic activity of the essential oilDysphania ambrosioides(L.) Mosyakin & Clemants. It exhibited an IC50= 0.7 mg/mL against trophozoites. The oral administration of essential oil (8 mg/kg and 80 mg/kg) to hamster infected withEntamoeba histolyticareverted the infection. Ascaridole was identified as the main component of essential oil ofD. ambrosioides. The identification of amoebicidal activity of Ascaridole gives support to the traditional use. Further studies with Ascaridole will be carried out to understand the mechanism involved.

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4

Owolabi, Moses S., Labunmi Lajide, Matthew O. Oladimeji, et al. "Volatile Constituents and Antibacterial Screening of the Essential Oil of Chenopodium Ambrosioides L. Growing in Nigeria." Natural Product Communications 4, no. 7 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400724.

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The essential oil of the aerial parts of Chenopodium ambrosioides L. has been isolated by hydrodistillation and analyzed using GCMS. The major components were found to be α-terpinene (63.1%), p-cymene (26.4%) and ascaridole (3.9%). The oil displayed no antibacterial activity against either Gram-positive bacteria Bacillus cereus or Staphylococcus aureus, or the Gram-negative bacterium Escherichia coli (MIC = 1250 μg/mL). A cluster analysis of C. ambrosioides essential oils reveals at least seven distinct chemotypes: ascaridole, α-terpinene, α-pinene, p-cymene, carvacrol, α-terpinyl acetate, and limonene.

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5

Pichler, Gerald. "Detection of ascaridole activation in Leishmania." Intrinsic Activity 4, Suppl. 3 (2016): A2.1. http://dx.doi.org/10.25006/ia.4.s3-a2.1.

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6

Geroldinger, Gerald, Matthias Tonner, Hubert Hettegger, et al. "Mechanism of ascaridole activation in Leishmania." Biochemical Pharmacology 132 (May 2017): 48–62. http://dx.doi.org/10.1016/j.bcp.2017.02.023.

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7

Hsu, Kuang-Ping, Mei-Ling Yang, Liang Yu Wei, Hui-Tung Ho, and Chen-Lung Ho. "Chemical Composition and In Vitro Anti-Wood-Decay Fungal Activities of Dysphania ambrosioides Leaf Essential Oil From Taiwan." Natural Product Communications 17, no. 5 (2022): 1934578X2210999. http://dx.doi.org/10.1177/1934578x221099971.

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We evaluated the leaf essential oil in whole or fractions of Dysphania ambrosioides with respect to their resistance to wood decay fungal activities in vitro of 4 fungi. The main ingredients with the greater anti-wood decay capability were also identified. Fresh leaves of D. ambrosioides were hydrodistillated in a Clevenger-type apparatus and the resulting oil characterized using GC-FID and GC-MS instruments. The essential oil was found to consist of α-terpinene (30.5%), p-cymene (17.3%), carvacrol (16.2%), and ascaridole (15.1%). The oil showed resistance to wood decay activity of Trametes versicolor, Phanerochaete chrysosporium, Phaeolus schweinitzii, and Lenzites sulphureu. The oil had excellent resistance to wood decay fungal activities, and the active compounds were shown to be carvacrol and ascaridole.

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8

Dembitsky, Valery, Ilya Shkrob, and Lumir Ondrej Hanus. "ASCARIDOLE AND RELATED PEROXIDES FROM THE GENUS CHENOPODIUM." Biomedical Papers 152, no. 2 (2008): 209–15. http://dx.doi.org/10.5507/bp.2008.032.

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9

Christoffers, Wietske Andrea, Brunhilde Blömeke, Pieter-Jan Coenraads, and Marie-Louise Anna Schuttelaar. "Co-sensitization to ascaridole and tea tree oil." Contact Dermatitis 69, no. 3 (2013): 187–89. http://dx.doi.org/10.1111/cod.12086.

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10

Gille, Lars, Gerald Geroldinger, Matthias Tonner, et al. "The activation of the endoperoxide ascaridole in Leishmania." Free Radical Biology and Medicine 108 (July 2017): S32. http://dx.doi.org/10.1016/j.freeradbiomed.2017.04.130.

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11

Satyal, Prabodh, Prajwal Paudel, Ananad Kafle, et al. "Bioactivities of Volatile Components from Nepalese Artemisia Species." Natural Product Communications 7, no. 12 (2012): 1934578X1200701. http://dx.doi.org/10.1177/1934578x1200701228.

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The essential oils from the leaves of Artemisia dubia, A. indica, and A. vulgaris growing wild in Nepal were obtained by hydrodistillation and analyzed by GC-MS. The major components in A. dubia oil were chrysanthenone (29.0%), coumarin (18.3%), and camphor (16.4%). A. indica oil was dominated by ascaridole (15.4%), isoascaridole (9.9%), trans-p-mentha-2,8-dien-1-ol (9.7%), and trans-verbenol (8.4%). The essential oil of Nepalese A. vulgaris was rich in α-thujone (30.5%), 1,8-cineole (12.4%), and camphor (10.3%). The essential oils were screened for phytotoxic activity against Lactuca sativa (lettuce) and Lolium perenne (perennial ryegrass) using both seed germination and seedling growth, and all three Artemisia oils exhibited notable allelopathic activity. A. dubia oil showed in-vitro cytotoxic activity on MCF-7 cells (100% kill at 100 μg/mL) and was also marginally antifungal against Aspergillus niger (MIC = 313 μg/mL). DFT calculations (B3LYP/6-31G*) revealed thermal decomposition of ascaridole to be energetically accessible at hydrodistillation and GC conditions, but these are spin-forbidden processes. If decomposition does occur, it likely proceeds by way of homolytic peroxide bond cleavage rather than retro-Diels-Alder elimination of molecular oxygen.

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12

Krutz, N. L., J. Hennen, C. Korb, M. T. Schellenberger, G. F. Gerberick, and B. Blömeke. "Activation of the endoperoxide ascaridole modulates its sensitizing capacity." Toxicology Letters 238, no. 2 (2015): S222. http://dx.doi.org/10.1016/j.toxlet.2015.08.657.

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13

Pastor, Jacinta, Marley García, Silvia Steinbauer, et al. "Combinations of ascaridole, carvacrol, and caryophyllene oxide against Leishmania." Acta Tropica 145 (May 2015): 31–38. http://dx.doi.org/10.1016/j.actatropica.2015.02.002.

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14

Krutz, Nora L., Jennifer Hennen, Corinna Korb, Mario T. Schellenberger, G. Frank Gerberick, and Brunhilde Blömeke. "Activation of the Endoperoxide Ascaridole Modulates Its Sensitizing Capacity." Toxicological Sciences 147, no. 2 (2015): 515–23. http://dx.doi.org/10.1093/toxsci/kfv148.

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15

Opsenica, Igor, Dejan Opsenica, Milka Jadranin, et al. "On peroxide antimalarials." Journal of the Serbian Chemical Society 72, no. 12 (2007): 1181–90. http://dx.doi.org/10.2298/jsc0712181o.

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Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure-activity relationship of this kind of antimalarials. The tetraoxanes 2-5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. They have better than or similar activity to the corresponding desmethyl dicyclohexylidene derivatives. Two chimeric endoperoxides with superior antimalarial activity to the natural product ascaridole were also synthesized.

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16

Pollack, Y., R. Segal, and J. Golenser. "The effect of ascaridole on the in vitro development ofPlasmodium falciparum." Parasitology Research 76, no. 7 (1990): 570–72. http://dx.doi.org/10.1007/bf00932563.

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17

Pavela, Roman, Giovanni Benelli, Riccardo Petrelli, et al. "Exploring the Insecticidal Potential of Boldo (Peumus boldus) Essential Oil: Toxicity to Pests and Vectors and Non-target Impact on the Microcrustacean Daphnia magna." Molecules 24, no. 5 (2019): 879. http://dx.doi.org/10.3390/molecules24050879.

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Every year Chile exports about 2000 tons of boldo folium (Peumus boldus), which is used around the world as a traditional herbal medicinal product (THMP), mostly to relieve gastrointestinal disorders. This biomass may be a resource for the agrochemical industry to manufacture botanical insecticides. In this regard, the insecticidal potential of boldo has been poorly investigated. In the present work, hydrodistillation of a commercial boldo folium gave 1.5% (w/w) of a yellowish essential oil (boldo essential oil, BEO) containing 1,8-cineole (20.7%), p-cymene (18.5%), limonene (9.1%), ascaridole (9.1%) and β-phellandrene (6.4%) as the main constituents, as determined by gas chromatography-mass spectrometry (GC-MS). NMR analysis allowed us to determine that ascaridole was mainly represented by the cis-isomer. BEO was toxic to larvae of the filariasis vector Culex quinquefasciatus and adults of the housefly Musca domestica, showing LC50/LD50 values of 67.9 mg·L−1 and 98.5 µg·adult−1, respectively. On the other hand, lower insecticidal activity was observed against larvae of the moth pest Spodoptera littoralis (LD50 of 268.9 µg·larva−1). It is worth noting that, when tested at LC90 concentration, BEO was significantly less toxic to aquatic microcrustacean Daphnia magna than the conventional insecticide α-cypermethrin. Finally, in the attempt to explore the BEO mode of action, we tested it for acetylcholinesterase (AChE) inhibitory properties using the Ellman method, obtaining negligible effects (IC50 = 0.45 mg·mL−1). Taken together, these results gave new insights into the potential of BEO as a future ingredient of botanical insecticides.

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18

Kaul, Vijay K. "Analysis of the Essential Oil of the Leaves of the Medicinal Plant Chenopodium ambrosioides var. anthelminticum (L.) A. Gray from India." Scientia Pharmaceutica 68, no. 1 (2000): 123–28. http://dx.doi.org/10.3797/scipharm.aut-00-11.

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The composition of the essential oil of Chenopodium ambrosioides var. anthelminticum L. (Chenopodiaceae) leaves (also commonly known as American Wormseed, wormseed goosefood or sweet pig weed) from India (Himalayan area) was analyzed by GC-FID, GC-MS and olfactometry. As main compounds α-terpinene (65.4%) and para-cymene (29.4%) were found. Surprisingly the concentration of ascaridole, the main compound of Chenopodium species from various origin, was very low (0.7%) in this sample. The chromatographic-spectroscopic and olfactoric data as well as a possible influence of the identified volatiles on the reported biological effects will be discussed.

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19

Mahmoud, Ahmed A., and Shar S. Al-Shihry. "A New Ionone Glucoside and Terpenoid Constituents from Achillea biebersteinii and their Antifungal Activity." Natural Product Communications 1, no. 9 (2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100901.

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A new ionone glucoside, (-)(4R*, 5R*)-5-(β-D-glucopyranosyloxymethyl)-4-hydroxy-3,5-dimethyl-4-((E)-3-oxobut-1-enyl)cyclohex-2-enone (biebersteiniside) (1), in addition to four known compounds, 6-epiroseoside (2), ascaridole (3), strictic acid (4) and centipedic acid (5) have been isolated from the aerial parts of Achillea biebersteinii Afan. The structures were determined from extensive 500 MHz NMR 1D (1H and 13C NMR) and 2D (1H-1H COSY, HMQC, HMBC and NOESY) spectroscopic data. Compounds 2–5 are reported for the first time from this plant. In addition, compounds 1a and 3–5 showed antifungal activity.

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20

Hatzakis, Emmanuel, Igor Opsenica, Bogdan A. Solaja, and Manolis Stratakis. "Synthesis of novel polar derivatives of the antimalarial endoperoxides ascaridole and dihydroascaridole." Arkivoc 2007, no. 8 (2006): 124–35. http://dx.doi.org/10.3998/ark.5550190.0008.812.

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21

OKUYAMA, Emi, Kazuhiro UMEYAMA, Yukie SAITO, Mikio YAMAZAKI, and Motoyoshi SATAKE. "Ascaridole as a Pharmacologically Active Principle of "Paico", a Medicinal Peruvian Plant." CHEMICAL & PHARMACEUTICAL BULLETIN 41, no. 7 (1993): 1309–11. http://dx.doi.org/10.1248/cpb.41.1309.

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22

Djarri, Lakhdar, Nabila Souilah, Hamdi Bendif, et al. "Chemical Composition of Volatile Organic Compounds of an Extremely Rare and Endemic Algerian Apiaceae Species, Bunium crassifolium Batt." Acta Biologica Marisiensis 6, no. 1 (2023): 1–9. http://dx.doi.org/10.2478/abmj-2023-0001.

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Abstract Bunium crassifolium Batt. (B. crassifolium) (Apiaceae) is an extremely rare endemic species from the North East of Algeria. In this study, we extracted the volatile organic compounds (VOC) of B. crassifolium Batt. aerial parts using an Agilent G1888 network headspace sampler coupled with an Agilent 7890 GC system. The results revealed the presence of twenty-two (22) compounds, twenty (20) of which were identified as representing 97.48% of the total composition, the major components are: 44.67% of β-Cubebene, 8.82% of β-Caryophyllene, 7.04% of γ-Elemene, 4.70% of δ-Cadinene, 4.11% of γ-Cadinene, 3.77% of Ascaridole and 3.33% of β-Elemene, along with other constituents at a relatively low amount.

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23

Yen, Yao-Pin, Ming-Jen Yeh, and Wen-Feng Hsiao. "Synthesis and nematocidal activity of ascaridole derivatives against Meloidogyne incognita and Aphelenchoides besseyi." Journal of Pesticide Science 32, no. 1 (2007): 49–52. http://dx.doi.org/10.1584/jpestics.g06-44.

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24

Chu, Yang, Wei Li, Jianping Han, et al. "Determination and pharmacokinetics of ascaridole in rat plasma by gas chromatography–mass spectrometry." Journal of Pharmaceutical and Biomedical Analysis 48, no. 3 (2008): 997–1000. http://dx.doi.org/10.1016/j.jpba.2008.06.017.

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25

Zhao, Qiang, Baoan Gao, Lulu Ma, Jianhao Lian, Li Deng, and Jianming Chen. "Innovative intragastric ascaridole floating tablets: Development, optimization, and in vitro–in vivo evaluation." International Journal of Pharmaceutics 496, no. 2 (2015): 432–39. http://dx.doi.org/10.1016/j.ijpharm.2015.10.007.

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26

PATEL, Kanika, and Dinesh Kumar PATEL. "Biological activity of ascaridole for the treatment of cancers: Phytopharmaceutical importance with molecular study." Annals of Hepato-Biliary-Pancreatic Surgery 25, no. 1 (2021): S294. http://dx.doi.org/10.14701/ahbps.ep-93.

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27

Ovechkin, A. S., M. D. Reyngeverts та L. A. Kartsova. "Gas chromatographic determination of ascaridole – the product of singlet oxygen and α-terpinene reaction". Аналитика и контроль 17, № 4 (2013): 439–44. http://dx.doi.org/10.15826/analitika.2013.17.4.009.

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28

Chatzopoulou, Pashalina, Stavros T. Katsiotis, and Anders Baerheim Svendsen. "An Ascaridole Containing Essential Oil of theAchillea millefoliumL. Complex Growing Wild in Northern Greece." Journal of Essential Oil Research 4, no. 5 (1992): 457–59. http://dx.doi.org/10.1080/10412905.1992.9698109.

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29

Chittiboyina, Amar G., Cristina Avonto, and Ikhlas A. Khan. "What Happens after Activation of Ascaridole? Reactive Compounds and Their Implications for Skin Sensitization." Chemical Research in Toxicology 29, no. 9 (2016): 1488–92. http://dx.doi.org/10.1021/acs.chemrestox.6b00157.

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30

Bezerra, Daniel P, José D B. Marinho Filho, Ana Paula N N. Alves, et al. "Antitumor Activity of the Essential Oil from the Leaves ofCroton regelianusand Its Component Ascaridole." Chemistry & Biodiversity 6, no. 8 (2009): 1224–31. http://dx.doi.org/10.1002/cbdv.200800253.

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31

Christoffers, Wietske Andrea, Brunhilde Blömeke, Pieter-Jan Coenraads, and Marie-Louise Anna Schuttelaar. "The optimal patch test concentration for ascaridole as a sensitizing component of tea tree oil." Contact Dermatitis 71, no. 3 (2014): 129–37. http://dx.doi.org/10.1111/cod.12199.

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32

Donkers, Robert L., and Mark S. Workentin. "Kinetics of Dissociative Electron Transfer to Ascaridole and Dihydroascaridole—Model Bicyclic Endoperoxides of Biological Relevance." Chemistry - A European Journal 7, no. 18 (2001): 4012–20. http://dx.doi.org/10.1002/1521-3765(20010917)7:18<4012::aid-chem4012>3.0.co;2-a.

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33

Monzote, Lianet, Werner Stamberg, Katrin Staniek, and Lars Gille. "Toxic effects of carvacrol, caryophyllene oxide, and ascaridole from essential oil of Chenopodium ambrosioides on mitochondria." Toxicology and Applied Pharmacology 240, no. 3 (2009): 337–47. http://dx.doi.org/10.1016/j.taap.2009.08.001.

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34

Hewis, Lavisiony Gracius, Giovanni Batista Christian Daeli, Kenjiro Tanoto, Carlos Carlos, and Agnes Anania Triavika Sahamastuti. "A Review of Botany, Phytochemical, and Pharmacological Effects of Dysphania ambrosioides." Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online) 2, no. 2 (2020): 70–82. http://dx.doi.org/10.54250/ijls.v2i2.42.

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Traditional medicine is widely used worldwide due to its benefits and healthier components that these natural herbs provide. Natural products are substances produced or retrieved from living organisms found in nature and often can exert biological or pharmacological activity, thus making them a potential alternative for synthetic drugs. Natural products, especially plant-derived products, have been known to possess many beneficial effects and are widely used for the treatment of various diseases and conditions. Dysphania ambrosioides is classified as an annual or short-lived perennial herb commonly found in Central and South America with a strong aroma and a hairy characteristic. Major components in this herb are ascaridole, p-cymene, α-terpinene, terpinolene, carvacrol, and trans-isoascaridole. Active compounds isolated from this herb are found to exert various pharmacological effects including schistosomicidal, nematicidal, antimalarial, antileishmanial, cytotoxic, antibacterial, antiviral, antifungal, antioxidant, anticancer, and antibiotic modulatory activity. This review summarizes the phytochemical compounds found in the Dysphania ambrosioides, together with their pharmacological and toxicological effects.

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35

Magri, David C., and Mark S. Workentin. "Kinetics of the photoinduced dissociative reduction of the model alkyl peroxides di-tert-butyl peroxide and ascaridole." Mediterranean Journal of Chemistry 1, no. 6 (2012): 303–15. http://dx.doi.org/10.13171/mjc.1.6.2012.10.06.13.

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36

de Castro, Débora Silva Borges, Denise Brentan da Silva, Jacqueline Domingues Tibúrcio, et al. "Larvicidal activity of essential oil of Peumus boldus Molina and its ascaridole-enriched fraction against Culex quinquefasciatus." Experimental Parasitology 171 (December 2016): 84–90. http://dx.doi.org/10.1016/j.exppara.2016.10.008.

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37

Anatachodwanit, Aknarin, Phunrawie Promnart, Suwanna Deachathai, et al. "Chemical Composition of the Essential Oils from Goniothalamus tortilipetalus M.R.Hend. and Their Antioxidant and Antibacterial Activities." Chemistry 6, no. 2 (2024): 264–71. http://dx.doi.org/10.3390/chemistry6020013.

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This work was the first investigation of the essential oil composition of Goniothalamus tortilipetalus M.R.Hend. The aim of this study is to investigate the essential oil composition extracted from different parts of Goniothalamus tortilipetalus M.R.Hend., including flowers, leaves, and twigs, and to evaluate their antioxidant and antibacterial activities. The Clevenger apparatus was used for hydrodistillation to prepare the essential oils. The essential oils were investigated using gas chromatography–mass spectrometry (GC-MS). The three major compounds of the flowers were bicyclogermacrene (15.81%), selin-11-en-4-α-ol (14.68%), and E-caryophyllene (7.02%), whereas the leaves were p-cymene (39.57%), ascaridole (9.39%), and α-copaene (9.12%). In the case of the twigs, α-copaene (10.34%), selin-11-en-4-α-ol (8.85%), and p-cymene (7.76%) were the major compounds. The flower essential oil showed antioxidant activities with IC50 values of 725.21 µg/mL and 123.06 µg/mL for DPPH and ABTS assays, respectively. The flower essential oil also displayed antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, Salmonella typhimurium, and Shigella flexneri, with the same MIC value of 640 µg/mL.

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38

Yang, Ji-Yeon, Song-Hee Ryu, Sung-Jin Lim, Geun-Hyoung Choi, and Byung-Jun Park. "Quantitative Determination of Ascaridole, Carvacrol and p-Cymene in the Biopesticides Products Derived from Chenopodium ambrosioides L. Extracts by Gas Chromatography." Korean Journal of Environmental Agriculture 35, no. 3 (2016): 211–15. http://dx.doi.org/10.5338/kjea.2016.35.3.27.

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39

de Carvalho, Alexandre Alves, Suzan Kelly Vilela Bertolucci, Giselly Motta da Silva, et al. "Mesos components (CaCl2, MgSO4, KH2PO4) induced changes in growth and ascaridole content of Dysphania ambrosioides L. in vitro." Industrial Crops and Products 122 (October 2018): 28–36. http://dx.doi.org/10.1016/j.indcrop.2018.05.042.

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Ngọc, Nguyễn Văn, Hoàng Thị Bình, Đỗ Trần Thẩm Thuý та ін. "THÀNH PHẦN HOÁ HỌC VÀ HOẠT TÍNH KHÁNG VI SINH VẬT CỦA TINH DẦU DẦU GIUN (Dysphania ambrosioides (L.) Mosyakin & Clemants) Ở LÂM ĐỒNG". TNU Journal of Science and Technology 228, № 09 (2023): 251–58. http://dx.doi.org/10.34238/tnu-jst.7823.

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Nghiên cứu này nhằm đánh giá thành phần hoá học cũng như hoạt tính kháng vi sinh vật của tinh dầu loài dầu giun (Dysphania ambroisioides (L.) Mosyakin & Clemants) phân bố tại tỉnh Lâm Đồng. Phương pháp lôi cuốn hơi nước đã được sử dụng để tách chiết tinh dầu và phương pháp sắc ký khí - ghép khối phổ (GC-MS) để phân tích thành phần hoá học của tinh dầu. Ngoài ra, phương pháp khuếch tán giếng thạch được sử dụng trong nghiên cứu này để đánh giá khả năng kháng hai chủng vi sinh vật là Staphylococcus aureus, Escherichia coli và một chủng nấm men gây bệnh là Candida albicans của tinh dầu loài dầu giun ở các nồng độ pha loãng 12,5%, 25%, 50%, 75% và 100%. Kết quả đã xác định được 15 hợp chất có trong tinh dầu loài dầu giun thu ở Lâm Đồng với α-terpinene (74,70%) và ascaridole (17,93%), δ- cymene (3,04%) là những thành phần chiếm hàm lượng cao. Ở các nồng độ pha loãng khác nhau của tinh dầu đều thể hiện khả năng kháng tốt với cả 3 chủng vi sinh vật thử nghiệm.

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Bakker, Christiaan V., Brunhilde Blömeke, Pieter-Jan Coenraads, and Marie-Louse Schuttelaar. "Ascaridole, a sensitizing component of tea tree oil, patch tested at 1% and 5% in two series of patients." Contact Dermatitis 65, no. 4 (2011): 240–41. http://dx.doi.org/10.1111/j.1600-0536.2011.01948.x.

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MacDonald, D., K. VanCrey, P. Harrison, et al. "Ascaridole-less infusions of Chenopodium ambrosioides contain a nematocide(s) that is(are) not toxic to mammalian smooth muscle." Journal of Ethnopharmacology 92, no. 2-3 (2004): 215–21. http://dx.doi.org/10.1016/j.jep.2004.02.018.

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Sahli, F., B. Vileno, M. Taborda Silva e Sousa, J. Lichter, B. Bloemeke, and E. Gimenez-Arnau. "984 Formation of radicals from endoperoxide ascaridole in a 3D epidermis model and activation of the innate immune response." Journal of Investigative Dermatology 139, no. 5 (2019): S170. http://dx.doi.org/10.1016/j.jid.2019.03.1060.

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Hu, Xiaoqian, Yang Chu, Gang Ma та ін. "Simultaneous determination of ascaridole,p-cymene andα-terpinene in rat plasma after oral administration ofChenopodium ambrosioidesL. by GC-MS". Biomedical Chromatography 29, № 11 (2015): 1682–86. http://dx.doi.org/10.1002/bmc.3479.

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de Carvalho, Alexandre Alves, Suzan Kelly Vilela Bertolucci, Alan da Cunha Honorato, Tainá Teixeira Rocha, Sâmia Torres Silva, and José Eduardo Brasil Pereira Pinto. "Influence of light spectra and elicitors on growth and ascaridole content using in vitro cultures of Dysphania ambrosioides L." Plant Cell, Tissue and Organ Culture (PCTOC) 143, no. 2 (2020): 277–90. http://dx.doi.org/10.1007/s11240-020-01892-5.

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Monzote, Lianet, Marcelina R. Nance, Marley García, Ramón Scull, and William N. Setzer. "Comparative Chemical, Cytotoxicity and Antileishmanial Properties of Essential Oils from Chenopodium ambrosioides." Natural Product Communications 6, no. 2 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600232.

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In countries where leishmaniasis is endemic, there are not very many treatment alternatives and most options have problems associated with their use. Plants and their natural products constitute good sources of interesting lead compounds that could be potentially active against Leishmania. Chenopodium ambrosioides is a plant that is widely used in popular medicine and its antiparasitic effects have been documented, including the antileishmanial potentialities of Chenopodium oil. The objective of this study was to determine the chemical composition, in-vitro cytotoxicity and antileishmanial activity of essential oils extracted from C. ambrosioides, which received different treatments prior to extraction. The chemical characterization by GC-MS of the three essential oil samples showed similar composition and the major components were α-terpinene (17.0-20.7%), p-cymene (20.2-21.1%) and ascaridole (30.5-47.1%). The essential oils exhibited similar antileishmanial activities against intracellular amastigote form, with IC50 values between 4.7 and 12.4 μg/mL. However, a lower cytotoxicity was displayed by the essential oil extracted from fresh green vegetable material, which was statistically different ( P < 0.05) from the other samples. This study demonstrated that the prior treatment of plant material did not interfere with the antiparasitic activity of essential oils from C. ambrosioides but did change their cytotoxicity, which should be taken into account in further studies.

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Monzote, Lianet, Gerald Geroldinger, Matthias Tonner, et al. "Interaction of ascaridole, carvacrol, and caryophyllene oxide from essential oil of Chenopodium ambrosioides L. with mitochondria in Leishmania and other eukaryotes." Phytotherapy Research 32, no. 9 (2018): 1729–40. http://dx.doi.org/10.1002/ptr.6097.

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Cassels, Bruce K., Gonzalo Fuentes-Barros, and Sebastián Castro-Saavedra. "Boldo, Its Secondary Metabolites and their Derivatives." Current Traditional Medicine 5, no. 1 (2019): 31–65. http://dx.doi.org/10.2174/2215083804666181113112928.

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Boldo leaves (Boldo folium, from Peumus boldus Mol.) are very frequently used as a medicinal herb in Chile and are exported to many countries to be used in teas or as extracts included in herbal remedies, primarily as an aid to digestion and as a mild sedative. Scientific support for these uses is scanty, and boldine, an alkaloid viewed as characteristic of the tree and present in high concentration in the bark, is extracted by specialized companies and sold as the supposed main active constituent. Consequently, boldine has been the subject of a considerable number of research papers, while some of the other alkaloids present to a greater extent in the leaves have been relatively neglected except when found in large amounts in other species. These studies range from assays of antioxidant activity to anti-inflammatory, antineoplastic and other medical applications. The essential oil, usually containing a large percentage of the toxic ascaridole, was once used as a vermifuge and is now regarded with caution, but is still of interest as a possible natural insecticide, fungicide, antiparasitic and herbicide. The last decade has seen an explosive increase in papers pointing to possible uses of boldo and its constituents. This review attempts to bring these publications together in a comprehensive way with the purpose of stimulating and orienting further research into the useful properties of this Chilean endemic tree.

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Datta, Subhash C., and Kaasi N. Ghosh. "Allelopathy in two species of Chenopodium -inhibition of germination and seedling growth of certain weeds." Acta Societatis Botanicorum Poloniae 56, no. 2 (2014): 257–70. http://dx.doi.org/10.5586/asbp.1987.025.

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The activity of washed leaf and inflorescence material of <em>Chenopodium ambrosioides</em> and <em>C. murale</em>, decaying leaves and inflorescences, and field soils collected beneath <em>Chenopodium</em> plants were examined in terms of the inhibition of seed germination and seedling growth of five weeds, viz. <em>Abutilon indicum, Cassia sophera</em> var. <em>purpurea, C. tora, Evolvulus numularius</em> and <em>Tephrosia hamiltonii</em>. The allelopathic pattern varied in each of the two test species and this depended on the type of test matter. However, the germination as well as the root and hypocotyl growth of <em>A. indicum</em> and <em>E. nummularius</em> were more hampered by phytotoxins or inhibitors from <em>Chenopodium</em> than were the other weeds. Since the leaf and inflorescence of Chenopodium formed the source of inhibitors, the respective plant-parts from the two species were chemically analysed and the presence of three terpenes (p-cymene, ascaridole and aritazone) from <em>C. ambrosioides</em> and an organic acid (oxalic acid) from <em>C. murale</em> were implicated in the allelopathic effect.

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Haris, Abdullah, Muhammad Azeem, Muhammad Ghazanfar Abbas, Muhammad Mumtaz, Raimondas Mozūratis, and Muhammad Binyameen. "Prolonged Repellent Activity of Plant Essential Oils against Dengue Vector, Aedes aegypti." Molecules 28, no. 3 (2023): 1351. http://dx.doi.org/10.3390/molecules28031351.

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Repellents are effective personal protective means against outdoor biting mosquitoes. Repellent formulations composed of EOs are finding increased popularity among consumers. In this study, after an initial screening of 11 essential oils (EOs) at the concentration of 33 μg/cm2, five of the most repellent EOs, Perovskia atriplicifolia, Citrus reticulata (fruit peels), C. reticulata (leaves), Mentha longifolia, and Dysphania ambrosioides were further investigated for repellent activity against Aedes aegypti mosquitoes in time span bioassays. When tested at the concentrations of 33 μg/cm2, 165 μg/cm2 and 330 μg/cm2, the EO of P. atriplicifolia showed the longest repellent effect up to 75, 90 and 135 min, respectively, which was followed by C. reticulata (peels) for 60, 90 and 120 min, M. longifolia for 45, 60 and 90 min, and C. reticulata (leaves) for 30, 45 and 75 min. Notably, the EO of P. atriplicifolia tested at the dose of 330 μg/cm2 showed complete protection for 60 min which was similar to the commercial mosquito repellent DEET. Gas chromatographic-mass spectrometric analyses of the EOs revealed camphor (19.7%), limonene (92.7%), sabinene (24.9%), carvone (82.6%), and trans-ascaridole (38.8%) as the major constituents of P. atriplicifolia, C. reticulata (peels), C. reticulata (leaves), M. longifolia, and D. ambrosioides, respectively. The results of the present study could help develop plant-based commercial repellents to protect humans from dengue mosquitoes.

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