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Journal articles on the topic 'ASDR'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Li, Yingying, Wei Wang, Na Zhang, et al. "Antagonistic Regulation of ABA Responses by Duplicated Tandemly Repeated DUF538 Protein Genes in Arabidopsis." Plants 12, no. 16 (2023): 2989. http://dx.doi.org/10.3390/plants12162989.

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The plant hormone ABA (abscisic acid) regulates plant responses to abiotic stresses by regulating the expression of ABA response genes. However, the functions of a large portion of ABA response genes have remained unclear. We report in this study the identification of ASDs (ABA-inducible signal peptide-containing DUF538 proteins), a subgroup of DUF538 proteins with a signal peptide, as the regulators of plant responses to ABA in Arabidopsis. ASDs are encoded by four closely related DUF538 genes, with ASD1/ASD2 and ASD3/ASD4 being two pairs of duplicated tandemly repeated genes. The quantitativ

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Ellapen, T. J., M. Barnard, G. L. Strydom, K. M. Masime, and Y. Paul. "A Comparison Between Selected Noncommunicable Disease Mortality Rates Between 2010 and 2016 Among Selected Southern African Countries." International Quarterly of Community Health Education 41, no. 2 (2020): 119–23. http://dx.doi.org/10.1177/0272684x20916588.

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Researchers have identified cancer, diabetes mellitus, cardiovascular, and respiratory diseases as being the principal pathologies of increased aged standardized death rates (ASDRs) among noncommunicable diseases (NCDs). The objective of this study was to compare the change in the ASDR of these principal NCDs between the years 2010 and 2016 in Botswana, Mozambique, Namibia, South Africa, and Zimbabwe. ASDR data were collected from the 2016 Global Health Estimate. Among the selected Southern African countries for both 2010 and 2016, the order of prevalence of NCDs linked to increased ASDR was c

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Ding, Mengjuan, Shengjian Yu, Yurong Chen, Yewen Liu, and Feng Xuan. "Space-time analysis of head and neck cancer in Asia and its 34 countries and territories (1990–2021): Implications from the Global Burden of Disease Study 2021." PLOS One 20, no. 6 (2025): e0326177. https://doi.org/10.1371/journal.pone.0326177.

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Background Asia bears a disproportionate burden of head and neck cancer (HNC). This study aimed to analyze its spatial distribution and temporal trends in Asia from 1990 to 2021, projecting trends to 2030. Methods We performed a secondary analysis of data from the Global Burden of Disease Study (GBD) 2021, examining disability-adjusted life years (DALYs) for HNC and its five major subtypes: nasopharyngeal cancer (NPC), thyroid cancer (TC), laryngeal cancer (LC), lip and oral cavity cancer (LOC), and other pharyngeal cancer (OPC), across five Asian subregions and 34 countries/territories from 1

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Zhang, Wuxia, Huibo Guo, Shuo Liu, and Siyuan Wu. "Attention-Aware Spectral Difference Representation for Hyperspectral Anomaly Detection." Remote Sensing 15, no. 10 (2023): 2652. http://dx.doi.org/10.3390/rs15102652.

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Hyperspectral Anomaly Detection (HAD) aims to detect the pixel or target whose spectral characteristics are significantly different from the surrounding pixels or targets. The effectiveness of reconstructing the background model is an essential element affecting the improvement of the HAD performance. This paper proposes a Hyperspectral Anomaly Detection method based on Attention-aware Spectral Difference Representation (HAD-ASDR) to reconstruct more accurate background models by using the generated noise distribution matchable to the background as input. The proposed HAD-ASDR mainly includes

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Jani, Chinmay, Christian Mouchati, Nour Abdallah, et al. "Trends in prostate cancer mortality in the United States of America, by state and race, from 1999 to 2019: Estimates from the Centers for Disease Control WONDER database." Journal of Clinical Oncology 40, no. 6_suppl (2022): 30. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.030.

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30 Background: In the United States of America (USA), prostate cancer is the most common cancer in men, and it remained the second leading cause of cancer related mortality. It has a disproportionate burden of disease among minorities. In particular, African American (AA) men have a higher incidence and more aggressive disease course. Our study compares trends in prostate cancer mortality in the United States of America (USA) by race and state from 1999 to 2019. Methods: We used the Center for Disease Control (CDC) WONDER database using ICD-10 code C61 to extract mortality data for malignant p

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Adair, Tim, and Alan Lopez. "Widening inequalities in premature mortality in Australia, 2006-16." Australian Population Studies 4, no. 1 (2020): 37–56. http://dx.doi.org/10.37970/aps.v4i1.62.

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Background Increases in Australia’s life expectancy have slowed since 2003. Within this context, it is important to analyse whether socio-economic and geographic inequalities in premature mortality have changed in recent years. Aim The aim is to measure the extent of and change in inequalities in premature mortality (under 75 years) by area socio-economic status and remoteness in Australia from 2006-16. Data and methods This study uses Australian death registration data from 2006-16. We identify area socio-economic quintile (Q1 lowest to Q5 highest) and remoteness (major cities, in

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Zhang, Jingting, Jincheng Tang, Renyi Yang, Siqin Chen, Huiying Jian, and Puhua Zeng. "The Global, Regional, and National Burden of Tracheal, Bronchus, and Lung Cancer Caused by Smoking: An Analysis Based on the Global Burden of Disease Study 2021." Annals of Global Health 90, no. 1 (2024): 77. https://doi.org/10.5334/aogh.4572.

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Background: Smoking is the primary risk factor for tracheal, bronchus, and lung (TBL) cancer. Objective: This study aims to explore the epidemiological trends of smoking-attributable TBL cancer from 1990 to 2021. Methods: Mortality and disability-adjusted life-years (DALYs) data for smoking-related TBL cancer from 1990 to 2021 were sourced from the Global Burden of Disease Study (GBD) 2021. Estimated annual percentage changes (EAPCs) were calculated to evaluate trends in age-standardized mortality rates (ASMRs) and age-standardized DALY rates (ASDRs). Additionally, the relationship between dis

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Zhou, Jingyi, Chenglong Xi, Zhiyu Luan, Lufeng Mao, and Shiliang Ling. "Burden of Tracheal, Bronchus, and Lung Cancer Attributable to High Fasting Plasma Glucose." Archives of Iranian Medicine 28, no. 5 (2025): 286–95. https://doi.org/10.34172/aim.33332.

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Background: We aimed to evaluate the situation and change trends in the tracheal, bronchus, and lung (TBL) cancer burden attributable to high fasting plasma glucose (HFPG) stratified by gender, age, region, country, and sociodemographic index (SDI). Methods: We evaluated the age-standardized death rate (ASDR) and disability-adjusted life years (DALYs) rate of TBL cancer attributable to HFPG and their corresponding estimated annual percentage change (EAPC) trends in 204 countries and 21 regions. Results: Globally from 1990 to 2019, the ASDR (EAPC=0.98; 95% confidence interval [CI]: 0.82–1.15) a

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Faisal, Muhammad Salman, Muhammad Talha Shaukat, Wania Ur Rehman, et al. "Global and Regional Burden of Multiple Myeloma from 1980 to 2021: An Analysis of Gbd Study 2021." Blood 144, Supplement 1 (2024): 5170.6. https://doi.org/10.1182/blood-2024-211440.

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Background: Multiple myeloma (MM) is a hematologic malignancy characterized by the abnormal increase of monoclonal immunoglobulins. While the advent of novel targeted therapies and transplantation techniques has led to an improvement in five-year overall survival rates, it still carries a high risk of morbidity and mortality. Previous epidemiological studies have reported significant regional disparities in MM incidence and mortality rates. Here we aim to assess the global burden of MM and evaluate and explain regional disparities, if any. Methods: This study utilized data from the Global Burd

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Jani, Chinmay, Ingrid Salciccioli, Arashdeep Rupal, et al. "Trends in Breast Cancer Mortality Between 2001 and 2017: An Observational Study in the European Union and the United Kingdom." JCO Global Oncology, no. 7 (December 2021): 1682–93. http://dx.doi.org/10.1200/go.21.00288.

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PURPOSE Breast cancer is the most common cancer in women worldwide, representing 25.4% of the newly diagnosed cases in 2018. The past two decades have seen advancements in screening technologies, guidelines, and newer modalities of treatment. Our study reports and compares trends in breast cancer mortality in the European Union and the United Kingdom. MATERIALS AND METHODS We used the WHO Mortality Database. We extracted breast cancer mortality data from 2001 to 2017 on the basis of the International Classification of Diseases, 10th revision system. Crude mortality rates were dichotomized by s

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Lin, Dan, Xinping Lu, Ri Ma, and Xiaojuan Zeng. "Spatiotemporal Dynamics in the Burden of Lip and Oral Cavity Cancer and Attributable Risk Factors in Asia (1990–2021)." Healthcare 13, no. 12 (2025): 1377. https://doi.org/10.3390/healthcare13121377.

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Background/Objectives: Lip and oral cavity cancer (LOC) remains a critical public health challenge in Asia. This study evaluated spatiotemporal trends and risk factor contributions to LOC-related disability-adjusted life years (DALYs) from 1990 to 2021 to inform evidence-based healthcare policies. Methods: Using Global Burden of Disease (GBD) 2021 data, we analyzed LOC DALYs stratified by age, gender, risk factors (smoking, alcohol use, tobacco chewing), and subregions in Asia. Temporal trends were quantified via estimated annual percentage change (EAPC) across five geographic regions and soci

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Rehman, Aqeeb Ur, Wania Ur Rehman, Muhammad Talha Shaukat, et al. "Global and Regional Burden of Chronic Lymphocytic Leukemia from 1980 to 2021:an Analysis of Gbd Study 2021." Blood 144, Supplement 1 (2024): 7741. https://doi.org/10.1182/blood-2024-211629.

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Introduction Chronic lymphocytic leukemia (CLL) is a mature B-cell lymphoma primarily affecting elderly males and is estimated to be the most prevalent leukemia in developed countries. While the incidence of CLL has been documented to be increasing in recent years with an aging population, trends in CLL associated mortality remain understudied and less well-defined. Methods This study utilized data from the publicly available Global Burden of Diseases (GBD) database from 1980 to 2021, in order to examine chronic lymphocytic leukemia metrics, including age-standardized death rates (ASDR), Years

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Wan Husin, Wan Zakiyatussariroh, and Nazatul Shahreen Zainal Abidin. "Point forecasts of mortality rates in Malaysia: a comparison of principal component methods." Indonesian Journal of Electrical Engineering and Computer Science 19, no. 3 (2020): 1661. http://dx.doi.org/10.11591/ijeecs.v19.i3.pp1661-1669.

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<span>The problem of forecasting mortality has been widely discussed and is being considered as an important issue among actuaries and demographers. Using age and sex-specific mortality data in Malaysia, we compare and evaluate the point forecast accuracy of six principal component methods. These six methods are the Lee-Carter (LC) method, the unadjusted LC method (LCnone), the Lee-Miller (LM) variant, the Booth-Mandonald-Smith variant (BMS) and the two versions of the Hyndman-Ullah (HU). The overall performance of all methods was evaluated using out-sample forecasts based on the six err

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Wan, Zakiyatussariroh Wan Husin, and Shahreen Zainal Abidin Nazatul. "Point forecasts of mortality rates in Malaysia: A comparison of principal component methods." Indonesian Journal of Electrical Engineering and Computer Science 19, no. 3 (2020): 1661–69. https://doi.org/10.11591/ijeecs.v19.i3.pp1661-1669.

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The problem of forecasting mortality has been widely discussed and is being considered as an important issue among actuaries and demographers. Using age and sex-specific mortality data in Malaysia, we compare and evaluate the point forecast accuracy of six principal component methods. These six methods are the Lee-Carter (LC) method, the unadjusted LC method (LCnone), the Lee-Miller (LM) variant, the Booth-Mandonald-Smith variant (BMS) and the two versions of the Hyndman-Ullah (HU). The overall performance of all methods was evaluated using out-sample forecasts based on the six error measures

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Kundu, Rupayan, Niladri Kal, Abhay Singh, et al. "Epidemiological Trends in Incidence, Death and Associated Risk Factors of Multiple Myeloma 1990-2021 and Projection to 2040." Blood 144, Supplement 1 (2024): 1969. https://doi.org/10.1182/blood-2024-211861.

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Introduction: Multiple Myeloma (MM) constitutes about 1.8% of all newly diagnosed cancer cases and 2% of deaths related to cancer in 2024 in the US. We aim to investigate the epidemiological trends (incidence and death rates) and predictive factors of MM at global and regional level. Methods: The study analyzed data from 1990 to 2021, obtained from the Global Health Data Exchange 2021 database which is a comprehensive catalog of global health and demographic data, providing access to a wide range of datasets around the world. This study described the age-standardized rates (per 100,000 patient

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Jani, Chinmay, Samuel A. Kareff, Ana S. Salazar, and Janaki Neela Sharma. "Assessing tobacco-related mortality trends in genitourinary cancers: A 1990-2019 analysis." Journal of Clinical Oncology 42, no. 4_suppl (2024): 368. http://dx.doi.org/10.1200/jco.2024.42.4_suppl.368.

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368 Background: Tobacco consumption is a well-established risk factor for genitourinary cancers like urothelial and renal cell. This study aims to examine mortality trends associated with tobacco use in these cancer types, both globally and within the U.S., over the period of 1990 to 2019. Methods: Data from the Global Burden of Disease database, based on the International Classification of Diseases versions 10 and 9, were utilized to extract mortality statistics for bladder cancer (BC) and kidney cancer (KC). Age-standardized death rates (ASDRs) for the overall population, as well as Tobacco

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Li, Jingli, Chunyi Zhang, E. Qin, Jian Sun, Lingjing Liu, and Guimei Pu. "Global, regional and national burden of asthma attributable to NO₂from 1990 to 2021: an analysis from the Global Burden of Disease Study 2021." BMJ Open 15, no. 2 (2025): e095210. https://doi.org/10.1136/bmjopen-2024-095210.

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ObjectivesThis study aims to systematically assess the global, regional, and national burden of asthma attributable to nitrogen dioxide (NO₂) pollution.Design and settingAnalysis of population-level data from 1990 to 2021 obtained from the Global Burden of Disease Study 2021, covering 204 countries and territories.ParticipantsParticipants included patients with asthma attributable to NO₂ pollution.Main outcomes and measuresAsthma-related disability-adjusted life-years (DALYs) and age-standardised DALY rates (ASDR) attributable to NO₂ pollution across 204 countries and territories. The estimate

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Girum, Tadele, Dereje Mesfin, Jemal Bedewi, and Misgun Shewangizaw. "The Burden of Noncommunicable Diseases in Ethiopia, 2000–2016: Analysis of Evidence from Global Burden of Disease Study 2016 and Global Health Estimates 2016." International Journal of Chronic Diseases 2020 (February 20, 2020): 1–10. http://dx.doi.org/10.1155/2020/3679528.

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Background. The continuing rise in the burden of noncommunicable diseases (NCDs) is a key global health agendum due to the fact that NCDs cause more deaths than all other causes combined together. Although measuring the burden of NCD is very important to improve the existing health care systems and to monitor the progress of the program, a comprehensive estimate is lacking in Ethiopia. Hence, we aimed to systematically analyze the existing evidence to bring a solution. Methods. The research used data from the Global Burden of Disease Study (GBD 2016) and Global Health Estimates 2016 that origi

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Tregub, Ganna. "Seventh-day Adventists reformed movement: history and features of institutionalization in Ukraine." Ukrainian Religious Studies, no. 71-72 (November 4, 2014): 195–205. http://dx.doi.org/10.32420/2014.71-72.447.

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Seventh-day Adventists reformed movement: history and features of institutionalization in Ukraine. The article is devoted to consideration of specific processes of institualisation among the reformed Adventist movement (ASDR) in Ukraine. The feature of the process of institutionalization, ie the rise of the modern three different ASDR acting modern Ukrainian territories is analyzed.

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Inagaki, Yoshikazu, Naohisa Yoshida, Hikaru Hashimoto, et al. "An Additional 30-s Observation of the Right-Sided Colon Using a Novel Endoscopic System with Texture and Color Enhancement Imaging Decreases Polyp Miss Rates: A Multicenter Study." Diagnostics 15, no. 14 (2025): 1759. https://doi.org/10.3390/diagnostics15141759.

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Background/Objectives: White light imaging (WLI) of colonoscopy has a 26% adenoma miss rate. We aimed to evaluate the effectiveness of an additional 30 s (Add-30s) observation of the right-sided colon using a novel system (EVIS X1; Olympus Co.) with texture and color enhancement imaging (TXI). Methods: We reviewed 515 patients who underwent colonoscopy with Add-30s TXI between February 2021 and December 2023 at three affiliated hospitals. After initial right-sided colon observation with WLI, the colonoscope was reinserted into the cecum, and the right-sided colon was re-observed with Add-30s T

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Ahmad, Shahzaib, Muhammad Talha Shaukat, Wania Ur Rehman, Aleenah Mohsin, Aqeeb Ur Rehman, and Stephanie L. Graff. "The global and regional disease burden of breast cancer from 1980 to 2021: An analysis of GBD study 2021." JCO Oncology Practice 20, no. 10_suppl (2024): 146. http://dx.doi.org/10.1200/op.2024.20.10_suppl.146.

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146 Background: Breast cancer (BC) is the most common malignancy in women and presents a huge disease burden worldwide. Early detection, via mammographic screening, improves outcomes significantly. We present estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, delineating the trajectory of BC from 1980 - 2021. This analysis considers the impact of screening practices on the incidence and mortality of patients worldwide, offering comprehensive examination of trends over the past 4 decades. Methods: Data were methodically retrieved from GBD study, which inc

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Cuadrat-Grzybowski, Michal, and Eberhard Gill. "Generation of Secondary Space Debris Risks from Net Capturing in Active Space Debris Removal Missions." Aerospace 11, no. 3 (2024): 236. http://dx.doi.org/10.3390/aerospace11030236.

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Mitigation strategies to eliminate existing space debris, such as with Active Space Debris Removal (ASDR) missions, have become increasingly important. Among the considered ASDR approaches, one involves using a net as a capturing mechanism. A fundamental requirement for any ASDR mission is that the capture process itself should not give rise to new space debris. However, in simulations of net capturing, the potential for structural breaking is often overlooked. A discrete Multi-Spring-Damper net model was employed to simulate the impact of a 30 m × 30 m net travelling at 20 m/s onto an ESA Env

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Xia, Meng, Yingchao Shi, Hongtao Zhu, and Yanan Ji. "Global ischemic heart disease burden attributable to kidney dysfunction from 1990 to 2021 and projections to 2050: results from the global burden of disease study 2021." Frontiers in Cardiovascular Medicine 12 (May 23, 2025). https://doi.org/10.3389/fcvm.2025.1601549.

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BackgroundIschemic heart disease (IHD) is the leading cause of death of non-communicable diseases globally, presenting with particularly prominent metabolic risk associated with kidney dysfunction in the middle-aged and older populations. Accordingly, the present study intended to clarify trends in IHD burden attributable to kidney dysfunction from 1990 to 2021, with projection to 2050, in the middle-aged and older populations.MethodsThis study quantified the burden of IHD attributable to kidney dysfunction in middle-aged and older populations from 1990 to 2021 through deaths, disability-adjus

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Li, Junxiao, Qiongqiong Zhong, Shixiang Yuan, and Feng Zhu. "Global burden of stroke attributable to high systolic blood pressure in 204 countries and territories, 1990–2019." Frontiers in Cardiovascular Medicine 11 (April 26, 2024). http://dx.doi.org/10.3389/fcvm.2024.1339910.

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BackgroundHigh systolic blood pressure (HSBP) is severely related to stroke, although the global burden of stroke associated with HSBP needs to be understood.Materials and methodsData derived from the Global Burden of Disease, Injuries, and Risk Factors Study were used to analyze deaths, disability-adjusted life years (DALYs), age-standardized rates of mortality (ASMR), age-standardized rates of DALY (ASDR), and estimated annual percentage change (EAPC).ResultsGlobally, 52.57% of deaths and 55.54% of DALYs from stroke were attributable to HSBP in 2019, with higher levels in men; the ASMRs and

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Rehman, Wania, Muhammad Talha Shaukat, Aqeeb Ur Rehman, et al. "Abstract 4145471: Global And Regional Burden Of Alcoholic Cardiomyopathy From 1980 To 2021: An Analysis Of Global Burden Of Disease (GBD) Study 2021." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4145471.

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Background: Alcoholic cardiomyopathy (ACM) is induced by chronic alcohol consumption and is a predominant cause of non ischemic dilated cardiomyopathy. Here we evaluate the trends of ACM from 1980 to 2021, while focusing on locoregional variations which will help identify the areas with the highest disease burden and guide future investigation into underlying causes. Methods: Data extraction from the Global Burden of Diseases (GBD) study encompassed age-standardized death rates (ASDR), Years of Lost Life (YLL), and disability-adjusted life years (DALYs). The dataset was globally stratified by

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Wang, Lanhui, Yining He, Chao Han, et al. "Global burden of chronic kidney disease and risk factors, 1990–2021: an update from the global burden of disease study 2021." Frontiers in Public Health 13 (July 24, 2025). https://doi.org/10.3389/fpubh.2025.1542329.

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IntroductionThe burden of chronic kidney disease (CKD) varies across regions. This study provides comprehensive global, regional, and national estimates of total CKD and CKD due to four specific etiologies from 1990 to 2021.MethodsData were extracted from the 2021 Global Burden of Disease study, categorized by sex, 20 age groups, 204 countries or territories, and 5 sociodemographic index (SDI) regions. Age-standardized incidence rates (ASIRs), age-standardized prevalence rates (ASPRs), age-standardized death rates (ASDRs), age-standardized disability-adjusted life year rates (ASDARs) and risk

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Chen, Mingxing, Jiangxi Li, Wei Su, et al. "Global Burden of Lip and Oral Cavity Cancer From 1990 to 2021 and Projection to 2040: Findings From the 2021 Global Burden of Disease Study." Cancer Medicine 14, no. 9 (2025). https://doi.org/10.1002/cam4.70957.

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ABSTRACTBackgroundThe aim of this study was to estimate the global burden of lip and oral cavity cancer (LOC) and its trends in different genders, age groups, regions, and countries globally.MethodsData were sourced from the Global Burden of Disease 2021 study.ResultsDuring the 32‐year period, a 92.92% and 113.94% increase was estimated in the absolute counts of LOC deaths and disability‐adjusted life years (DALYs), respectively. Throughout the 32‐year period, males exhibited higher age‐standardized rates (ASRs) of incidence (ASIRs), prevalence (ASPRs), mortality (ASMRs), and DALYs (ASDRs) rel

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"ASDR Abstracts." Journal of Investigative Dermatology 129, no. 12 (2009): 2908–23. http://dx.doi.org/10.1038/jid.2009.333.

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Liu, Yan, Qin He, Qiying Li, et al. "Global incidence and death estimates of chronic kidney disease due to hypertension from 1990 to 2019, an ecological analysis of the global burden of diseases 2019 study." BMC Nephrology 24, no. 1 (2023). http://dx.doi.org/10.1186/s12882-023-03391-z.

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Abstract Background The intricate relationship between hypertension and chronic kidney disease (CKD) presents a global challenge for prevention of hypertension-related CKD. This study’s objective is to analyze age, gender, regional disparities, and evolving trends in the disease burden of hypertension-related CKD. We aim to estimate changing spatial and temporal trends in incidence and mortality rates, considering the socio-demographic index (SDI), to inform health strategies effectively. Method Age-standardized incidence rates (ASIR) and death rates (ASDR) were collected from the GBD 2019. Tr

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Zhu, Ning, Yan Zhang, Mi Mi, et al. "The death burden of colorectal cancer attributable to modifiable risk factors, trend analysis from 1990 to 2019 and future predictions." Cancer Medicine 13, no. 7 (2024). http://dx.doi.org/10.1002/cam4.7136.

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AbstractBackgroundThe death burden attributable to modifiable risk factors is key to colorectal cancer (CRC) prevention. This study aimed to assess the prevalence and regional distribution of attributable CRC death burden worldwide from 1990 to 2019.MethodsWe extracted data from the Global Burden of Disease Study in 2019 and assessed the mortality, age‐standardized death rate (ASDR), population attributable fractions, and time trend in CRC attributable to risk factors by geography, socio‐demographic index (SDI) quintile, age, and sex.ResultsOver the past 30 years, from high to low SDI region,

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Shaukat, Muhammad Talha, Bibi Maryam, Aqeeb Ur Rehman, et al. "Global and regional burden of high BMI-related pancreatic cancer from 1990 to 2021: An analysis of GBD study 2021." Journal of Clinical Oncology 43, no. 16_suppl (2025). https://doi.org/10.1200/jco.2025.43.16_suppl.e16431.

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e16431 Background: Obesity and overweight represent a significant concern for public health, with recent statistics showing that approximately two thirds of Americans have a body mass index (BMI) above 25. Estimates suggest that obesity and overweight is associated with a 20% increased risk of pancreatic cancer. With the ongoing global obesity epidemic, we aimed at exploring the evolving trends in global burden of high-BMI related pancreatic cancer and identify locoregional healthcare disparities. Methods: This study utilized data from the Global Burden of Diseases (GBD) database to examine hi

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Yang, Minxia, Feng Xuan, Liejiong Wang, Ying Lou, and Shengjian Yu. "Spatial patterns and temporal trends of tracheal, bronchus, and lung cancer attributed to particulate matter pollution in Asia and its 34 countries and territories, 1990–2021." Frontiers in Public Health 13 (July 24, 2025). https://doi.org/10.3389/fpubh.2025.1602454.

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BackgroundThis study aimed to investigate the spatial and temporal variations of tracheal, bronchus, and lung cancer (TBLC) attributable to particulate matter pollution across 34 Asian countries and territories from 1990 to 2021.MethodsDisability-adjusted life years (DALYs) linked to ambient particulate-matter pollution (APMP) and household air pollution (HAP) were obtained from the Global Burden of Disease (GBD) 2021 dataset, and performed analyses stratified by location, gender, and age. Trends in age-standardized DALY rates (ASDRs) were quantified with Joinpoint regression. Decomposition an

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Li, Jie, Lin Shen, and Kun Qian. "Global, regional, and national incidence and mortality of neonatal sepsis and other neonatal infections, 1990–2019." Frontiers in Public Health 11 (March 14, 2023). http://dx.doi.org/10.3389/fpubh.2023.1139832.

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BackgroundNeonatal infections, especially neonatal sepsis, are one of the major causes of incidence and mortality in pediatrics. However, the global burden of neonatal sepsis and other neonatal infections (NSNIs) remains unclear.MethodsFrom the 2019 global disease burden study, we collected annual incident cases, deaths, age-standardized incidence rates (ASIRs), and age-standardized deaths rates (ASDRs) of NSNIs in the past 30 years. Analysis indicators included the percentage of relative changes in incident cases and deaths, and the estimated annual percentage changes (EAPCs) of ASIRs and ASD

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Shaukat, Muhammad Talha, Wania Rehman, Malik Saad Hayat, et al. "Abstract 4148102: Trends in the Burden of Ischemic Stroke and Kidney Dysfunction; An analysis of Global Burden of Disease 1990-2021." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4148102.

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Introduction: Ischemic stroke and renal failure frequently coexist, impairing patient outcomes. Comprehending this association is imperative in formulating a multidisciplinary methodology to augment patient outcomes and quality of life. Objective: We offer estimates showing the evolution of kidney dysfunction related ischemic stroke from 1990 to 2021. It will utilize disability-adjusted life years (DALYs), years of life lost (YLLs) and age-standardized death rates (ASDR) to find discrepancies overall survival outcomes in both sexes. Methods: Data on ASDR, DALY, and YLL were extracted from the

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Wei, Yongguang, Zedong Qin, Xiwen Liao, et al. "Pancreatic cancer mortality trends attributable to high fasting blood sugar over the period 1990–2019 and projections up to 2040." Frontiers in Endocrinology 15 (July 5, 2024). http://dx.doi.org/10.3389/fendo.2024.1302436.

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BackgroundPancreatic cancer (PC) is a prevalent malignancy within the digestive system, with diabetes recognized as one of its well-established risk factors.MethodsData on PC mortality attributed to high fasting blood sugar were retrieved from the Global Burden of Disease (GBD) study 2019 online database. To assess the temporal trends of PC burden attributable to high fasting plasma glucose (HFPG), estimated annual percentage changes (EAPCs) for age-standardized death rates (ASDRs) between 1990 and 2019 were determined using a generalized linear model. Furthermore, a Bayesian age-period-cohort

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"ASPCR-ASDR 2013." Pigment Cell & Melanoma Research 26, no. 3 (2013): E1—E27. http://dx.doi.org/10.1111/pcmr.12094.

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Qiu, Pei, Hairong He, Yuting Zhao, et al. "Global disease burden attributed to unsafe sex in 204 countries and territories from 1990 to 2019: results from the Global Burden of Disease Study 2019." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-40001-2.

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AbstractUnsafe sex has become a public safety problem that endangers society, and research on deaths and disability-adjusted life years (DALYs) related to unsafe sex is valuable for global policy-making. We aimed to estimate the deaths and DALYs attributable to unsafe sex by country, gender, age group, and sociodemographic status from 1990 to 2019. We extracted data on disease burden from the Global Disease Burden 2019 (GBD 2019) database for unsafe sex, including deaths, DALYs and age-standardized rates (ASRs). Comparative analyses were performed on data about deaths, DALYs and the responding

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Xu, Zhaohui, Letai Li, Yinqin Hu, et al. "Hypertensive heart disease mortality trends attributable to high body mass index over the period 1990-2021 and projections up to 2040." Archives of Medical Science, June 8, 2025. https://doi.org/10.5114/aoms/204185.

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IntroductionThis study aimed to evaluate trends in HHD mortality attributable to HBMI from 1990 to 2021 and projections up to 2040.Material and methodsData on HHD mortality attributable to HBMI were obtained from the Global Burden of Diseases (GBD) 2021 database. Temporal trends in the burden of HHD attributable to HBMI were analyzed using generalized linear models to calculate the estimated annual percentage change (EAPC) in age-standardized mortality rates (ASMR) and age-standardized disability-adjusted life-years (DALYs) rates (ASDR) from 1990 to 2021.ResultsFrom 1990 to 2021, the global AS

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He, Hairong, Liang Liang, Didi Han, Fengshuo Xu, and Jun Lyu. "Different Trends in the Incidence and Mortality Rates of Prostate Cancer Between China and the USA: A Joinpoint and Age-Period-Cohort Analysis." Frontiers in Medicine 9 (February 3, 2022). http://dx.doi.org/10.3389/fmed.2022.824464.

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PurposeThis study used data from the Global Burden of Disease Study 2019 (GBD 2019) to determine the differences in the incidence and mortality of prostate cancer (PCa) between China and the USA from 1990 to 2019.MethodThe age-standardized incidence rates (ASIRs) and age-standardized death rates (ASDRs) in China and the USA from 1990 to 2019 were extracted from GBD 2019. Annual percentage changes and relative risks of ASIR and ASDR were calculated using joinpoint regression analysis and age-period-cohort models, respectively.ResultsThe ASIR of PCa in China continually increased from 1990 to 20

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He, Hairong, Qingqing Liu, Ning Li, et al. "Trends in the incidence and DALYs of schizophrenia at the global, regional and national levels: results from the Global Burden of Disease Study 2017." Epidemiology and Psychiatric Sciences 29 (2020). http://dx.doi.org/10.1017/s2045796019000891.

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Abstract Aim Schizophrenia is a serious health problem worldwide. This systematic analysis aims to quantify the burden of schizophrenia at the global, regional and national levels using the Global Burden of Disease Study 2017 (GBD 2017). Methods We collected detailed information on the number of incidence cases, disability-adjusted life years (DALYs) and age-standardised incidence rate (ASIR) and age-standardised rate of DALYs (ASDR) during 1990–2017 from GBD 2017. The estimated annual percentage changes (EAPCs) in the ASIR and in the ASDR were calculated to quantify the temporal trends in the

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Shi, Liangwen, Zhixing Kuang, Jiannan Tu, et al. "Global, regional, and national burden of laryngeal cancer attributable to smoking, 1990–2021, and projections to 2036: a systematic analysis of the Global Burden of Disease study 2021." Frontiers in Public Health 13 (May 9, 2025). https://doi.org/10.3389/fpubh.2025.1583045.

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BackgroundLaryngeal cancer, predominantly linked to smoking, persists as a formidable global health challenge. Acquiring a deeper understanding of laryngeal cancer attributable to smoking (LCAS) burden and trends is essential for crafting nuanced and impactful prevention and intervention strategies.MethodsThe Disability-Adjusted Life Years (DALYs), mortality, and corresponding Age-Standardized DALY rate (ASDR) and Age-Standardized Mortality Rate (ASMR) were systematically evaluated using the GBD 2021 data. Temporal trends were characterized through Joinpoint regression analysis, while the infl

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Bai, Jianjun, Fang Shi, Yudiyang Ma, Donghui Yang, Chuanhua Yu, and Jinhong Cao. "The Global Burden of Type 2 Diabetes Attributable to Tobacco: A Secondary Analysis From the Global Burden of Disease Study 2019." Frontiers in Endocrinology 13 (July 22, 2022). http://dx.doi.org/10.3389/fendo.2022.905367.

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ObjectivesGrowing epidemiological studies have reported the relationship between tobacco and health loss among patients with type 2 diabetes (T2D). This study aimed to explore the secular trend and spatial distribution of the T2D burden attributable to tobacco on a global scale to better understand regional disparities and judge the gap between current conditions and expectations.MethodsAs a secondary analysis, we extracted data of tobacco-attributable T2D burden from the 2019 Global Burden of Disease Study (GBD). Joinpoint regression was adopted to determine the secular trend of age-standardi

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Ding, Ping, Lingyan Qi, Jinglei Wang, Min Tang, and Yujie Weng. "Worldwide impact of disease attributable to low physical activity for diabetes and kidney diseases." Frontiers in Endocrinology 16 (May 5, 2025). https://doi.org/10.3389/fendo.2025.1499381.

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BackgroundWe aimed to examine patterns of diabetes and kidney disease due to Low physical activity (LPA) in 204 countries between 1990 and 2021.MethodsData were from the Global Burden of Disease (GBD) 2021. Age-standardized death rate (ASDR) and age standardized disability-adjusted life years (DALYs) were estimated. In addition, annual percentage changes (EAPC) were calculated.ResultsThe age-standardized DALY rate (EAPC = 0.89; 95% CI: 0.85, 0.93) and age-standardized death rate (ASDR) of diabetes and kidney disease due to LPA increased (EAPC = 0.34; 95% CI: 0.28,0.39) during 1990 to 2021. Amo

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Liu, Ce, Li He, Xiaobing Shan, et al. "The Burden of Occupational Noise-Induced Hearing Loss From 1990 to 2019: An Analysis of Global Burden of Disease Data." Ear & Hearing, April 15, 2024. http://dx.doi.org/10.1097/aud.0000000000001505.

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Objectives: The relationship between long-term exposure to occupational noise and hearing loss has been extensively documented. We aimed to assess spatial and temporal changes in the burden of occupational noise-induced hearing loss (ONIHL) in 204 countries and territories with varying socio-demographic indexes (SDI) from 1990 to 2019. Design: Temporal and spatial trends in age-standardized disability-adjusted life year rates (ASDR) for ONIHL were estimated by sex, age, SDI level, country, and geographic region from 1990 to 2019. We used the Joinpoint model to calculate annual average percenta

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Liang, Junqing, Jun Shen, Yankai Guo, et al. "Global trends and epidemiological impact of metabolic risk factors on atrial fibrillation and atrial flutter from 1990 to 2021." Scientific Reports 15, no. 1 (2025). https://doi.org/10.1038/s41598-025-88744-4.

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Abstract Atrial fibrillation (AF) and atrial flutter (AFL) are cardiac arrhythmias associated with high morbidity and mortality. This cross-sectional observational study assesses the epidemiological burden of AF/AFL concerning metabolic risk factors using the Global Burden of Disease (GBD) 2021 database. Age-standardized disability-adjusted life years rate (ASDR), mortality, and estimated annual percentage change were calculated. The Bayesian Age-Period-Cohort model was utilized to predict future trends in ASDR and age-standardized mortality rate (ASMR) for AF/AFL 2030. Between 1990 and 2021,

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Hayat, Malik Saad, Muhammad Talha Shaukat, Wania Rehman, et al. "Abstract 4147580: Global and regional burden of alcohol-related hypertension from 1990 to 2021: An analysis of GBD study 2021." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4147580.

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Background and Aims: Hypertension stands as the foremost preventable cause of premature mortality and is expected to have a global burden of up to 55%. Here we aim to examine the trends in age-standardized death rates (ASDR), years of life lost (YLL), and disability-adjusted life years (DALY) for alcoholic hypertension, pinpoint the vulnerable populations, and raise awareness about the global health burden of alcohol-related hypertension. Methods: Data on alcohol-related hypertension was extracted from the Global Burden of Diseases 2021 study, including ASDR, YLL, and DALY from 1990 to 2021. T

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Dong, Tianyi, Shipeng Zhang, Hanyu Wang, et al. "Global, regional, and national disease burden of tobacco-related Alzheimer’s disease among individuals over the age of 55: a global burden of disease study." Frontiers in Public Health 13 (May 14, 2025). https://doi.org/10.3389/fpubh.2025.1581871.

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BackgroundAlzheimer’s disease is a progressive neurodegenerative disorder characterized by an insidious onset. Numerous studies have identified a significant association between tobacco use and Alzheimer’s disease. This study aims to explore the epidemiological patterns and trends concerning tobacco-related Alzheimer’s disease at global, national and regional levels.MethodsWe analyzed data on mortality, age-standardized DALY rate (ASDR), and estimated annual percentage changes (EAPCs) sourced from the Global Burden of Disease data for 2021. The analysis was further stratified by country and re

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Danpanichkul, Pojsakorn, Yanfang Pang, Luis Antonio Díaz, et al. "Alcohol‐Attributable Cancer: Update From the Global Burden of Disease 2021 Study." Alimentary Pharmacology & Therapeutics, April 27, 2025. https://doi.org/10.1111/apt.70163.

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ABSTRACTBackground and AimsAlcohol is a major risk factor for cancer development. Our study aimed to provide the updated global, regional and national burden of alcohol‐attributable cancer.Approach and ResultsWe analysed the Global Burden of Disease Study 2021 to determine the death and age‐standardised death rate (ASDR) from alcohol‐attributable cancer and the change of these measures between 2000 and 2021 (reflected as annual percent change [APC]), classified by region, nation and country's developmental status, which is based on the sociodemographic index (SDI).ResultsIn 2021, there were 34

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Shaukat, Muhammad Talha, Wania Rehman, Malik Saad Hayat, et al. "Abstract 4147474: Global and regional burden of alcohol-related atrial fibrillation from 1990 to 2021: An analysis of GBD study 2021." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4147474.

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Background and Aims: Atrial fibrillation constitutes a major global public health issue, with its epidemiological patterns having changed significantly over the past decades. In this study, we aimed to analyze trends of mortality due to alcoholic atrial fibrillation from 1990-2021, including identifying the patterns in age-standardized death rates (ASDR), years of life lost (YLL), and disability-adjusted life years (DALY) over time, and raising awareness about the global health burden of alcoholic atrial fibrillation. Methods: Data on alcohol-related atrial fibrillation was extracted from the

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Zhang, Yan, Yuwei Ding, Ning Zhu, et al. "Emerging patterns and trends in global cancer burden attributable to metabolic factors, based on the Global Burden of Disease Study 2019." Frontiers in Oncology 13 (January 19, 2023). http://dx.doi.org/10.3389/fonc.2023.1032749.

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BackgroundThe exponential growth of the cancer burden attributable to metabolic factors deserves global attention. We investigated the trends of cancer mortality attributable to metabolic factors in 204 countries and regions between 1990 and 2019.MethodsWe extracted data from the Global Burden of Disease Study (GBD) 2019 and assessed the mortality, age-standardized death rate (ASDR), and population attributable fractions (PAFs) of cancers attributable to metabolic factors. Average annual percentage changes (AAPCs) were calculated to assess the changes in the ASDR. The cancer mortality burden w

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