Journal articles: 'ASIDS (Disease)'

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Mishra, Rajni. "Smoking and Periodontal Disease - Review." Acta Scientific Dental Scienecs 2, no. 11 (October 31, 2019): 114–16. http://dx.doi.org/10.31080/asds.2019.03.0686.

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Abdelhamid, Ramy E., and Kathleen A. Sluka. "ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases." Physiology 30, no. 6 (November 2015): 449–59. http://dx.doi.org/10.1152/physiol.00030.2015.

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Chronic musculoskeletal pain is debilitating and affects ∼20% of adults. Tissue acidosis is present in painful musculoskeletal diseases like rheumatoid arthritis. ASICs are located on skeletal muscle and joint nociceptors as well as on nonneuronal cells in the muscles and joints, where they mediate nociception. This review discusses the properties of different types of ASICs, factors affecting their pH sensitivity, and their role in musculoskeletal hyperalgesia and inflammation.

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Mahmoud Alkeshan, Mohammad, Ji -Soo Song, Teo Jeon Shin, Hong -Keun Hyun, Jung -Wook Kim, Sang -Hoon Lee, Ki -Taeg Jang, and Young -Jae Kim. "Dental Treatment in a Child with Moyamoya Disease." Acta Scientific Dental Scienecs 2, no. 11 (October 23, 2019): 57. http://dx.doi.org/10.31080/asds.2019.03.0675.

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Robertson, Peter W. "Serology testing for syphilis in pregnancy: is it still relevant?" Microbiology Australia 29, no. 4 (2008): 174. http://dx.doi.org/10.1071/ma08174.

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Until the emergence of HIV and other more spectacular viral diseases, syphilis has probably been referred to more than any other infectious disease throughout history ? in theatre, literature and politics. During the 19th century, aside from being a notorious disease transmitted sexually, it was the diverse clinical and pathological forms of syphilis which led to much of this mystique and fear.

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Ashiq, Sohaila. "Children's Dental Diseases and Disabilities." Acta Scientific Dental Scienecs 3, no. 12 (November 8, 2019): 40–41. http://dx.doi.org/10.31080/asds.2019.03.0696.

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HA, Amitha, Panchakshari Prasanna B K, Akshatha B S, Kiran Y C, and Sangeetha S Patel. "Case Report -Peripheral Ossifying Fibroma with Congenital Heart Disease." Acta Scientific Dental Scienecs 2, no. 11 (October 28, 2019): 73–76. http://dx.doi.org/10.31080/asds.2019.03.0678.

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Rashid, Sadia, Sana Zafar, Ayma Syed, Danish Javed, Nadia Junaid, Muhammad Umair Dastgir Bhatti, and Muhammad Rizwan. "Correlation between Periodontal Disease and Oral Health Related Quality of Life." Acta Scientific Dental Scienecs 4, no. 10 (September 16, 2020): 21–25. http://dx.doi.org/10.31080/asds.2020.04.0935.

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Hasan, Shamimul. "Linear IgA Disease - A Rare Sub Epithelial Disorder: A Current Appraisal." Acta Scientific Dental Scienecs 4, no. 10 (September 28, 2020): 100–104. http://dx.doi.org/10.31080/asds.2020.04.0947.

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GÜREL-POLAT, Nuray. "OTOİMMÜN ROMATOİD HASTALIKLARDA OTOANTİKORLAR." Euroasia Journal of Mathematics, Engineering, Natural & Medical Sciences 8, no. 17 (September 25, 2021): 135–40. http://dx.doi.org/10.38065/euroasiaorg.627.

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The diagnosis of autoimmune rheumatoid diseases can be made by combining parameters consisting of clinical, histopathological, laboratory and immunological tests. Among these parameters, autoantibodies are of great benefit in differential diagnosis, especially for patients with unclear clinical data. Immunofluorescence, ELISA, immunodiffusion, immunoprecipitation and Western blot can be used to identify autoantibodies. While autoantibodies like antinukleer antibody, double stranded deoksiribonukleic asid and anti neutrophils antibody are detected by immunofluorescence as a golden standard test, Anti-cyclic Citrullinated Peptide Antibody (CCP), antiphospholipid antibodies (anti-cardiolipid) are evaluated by ELISA and ENA group by immunoblot or western blot. Today the number of autoantibodies that can be detected is over 100. The indication of some of these autoantibodies are not known even today. The definition of antinuclear antibody group autoantibodies plays a crucial role for the diagnosis and treatment of systemic and organ-specific illnesses. With these methods, practical, fast and trustworthy results in clinical medicine and clinical immunology can be obtained.

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katoch, Samriti. "Oral Dysbiosis – A Consequence of Microbial Shift and A Path to Periodontal Disease." Acta Scientific Dental Scienecs 2, no. 11 (October 23, 2019): 54–56. http://dx.doi.org/10.31080/asds.2019.03.0674.

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G, Prerana, Raajasiri Iyengar, and Gaurav . "“CRISPR Edited Haematopoietic Stem Cells”: Solution to Sickle Cell Disease - A Systematic Review." Acta Scientific Dental Scienecs 4, no. 4 (March 27, 2020): 103–6. http://dx.doi.org/10.31080/asds.2020.04.0820.

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Qadri, Yawar J., Arun K. Rooj, and Catherine M. Fuller. "ENaCs and ASICs as therapeutic targets." American Journal of Physiology-Cell Physiology 302, no. 7 (April 1, 2012): C943—C965. http://dx.doi.org/10.1152/ajpcell.00019.2012.

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The epithelial Na+channel (ENaC) and acid-sensitive ion channel (ASIC) branches of the ENaC/degenerin superfamily of cation channels have drawn increasing attention as potential therapeutic targets in a variety of diseases and conditions. Originally thought to be solely expressed in fluid absorptive epithelia and in neurons, it has become apparent that members of this family exhibit nearly ubiquitous expression. Therapeutic opportunities range from hypertension, due to the role of ENaC in maintaining whole body salt and water homeostasis, to anxiety disorders and pain associated with ASIC activity. As a physiologist intrigued by the fundamental mechanics of salt and water transport, it was natural that Dale Benos, to whom this series of reviews is dedicated, should have been at the forefront of research into the amiloride-sensitive sodium channel. The cloning of ENaC and subsequently the ASIC channels has revealed a far wider role for this channel family than was previously imagined. In this review, we will discuss the known and potential roles of ENaC and ASIC subunits in the wide variety of pathologies in which these channels have been implicated. Some of these, such as the role of ENaC in Liddle's syndrome are well established, others less so; however, all are related in that the fundamental defect is due to inappropriate channel activity.

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Ruan, Nina, Jacob Tribble, Andrew M. Peterson, Qian Jiang, John Q. Wang, and Xiang-Ping Chu. "Acid-Sensing Ion Channels and Mechanosensation." International Journal of Molecular Sciences 22, no. 9 (May 1, 2021): 4810. http://dx.doi.org/10.3390/ijms22094810.

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Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are activated by pH drops and nonproton ligands. They are part of the degenerin/epithelial sodium channel superfamily due to their sodium permeability. Predominantly expressed in the central nervous system, ASICs are involved in synaptic plasticity, learning/memory, and fear conditioning. These channels have also been implicated in multiple disease conditions, including ischemic brain injury, multiple sclerosis, Alzheimer’s disease, and drug addiction. Recent research has illustrated the involvement of ASICs in mechanosensation. Mechanosensation is a form of signal transduction in which mechanical forces are converted into neuronal signals. Specific mechanosensitive functions have been elucidated in functional ASIC1a, ASIC1b, ASIC2a, and ASIC3. The implications of mechanosensation in ASICs indicate their subsequent involvement in functions such as maintaining blood pressure, modulating the gastrointestinal function, and bladder micturition, and contributing to nociception. The underlying mechanism of ASIC mechanosensation is the tether-gate model, which uses a gating-spring mechanism to activate ASIC responses. Further understanding of the mechanism of ASICs will help in treatments for ASIC-related pathologies. Along with the well-known chemosensitive functions of ASICs, emerging evidence has revealed that mechanosensitive functions of ASICs are important for maintaining homeostasis and contribute to various disease conditions.

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Giovanna Ravera, Monica. "Cognitive Decline and Oral Microbiota. Pro-Inflammatory Conditions Become Risk Factors in Neurodegenerative Disease." Acta Scientific Dental Scienecs 4, no. 3 (February 27, 2020): 01–05. http://dx.doi.org/10.31080/asds.2020.04.0798.

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Salmazo Castro, Marcelo, Ana Virginia Santana Sampaio Castilho, Lucas José de Azevedo-Silva, Lorrayne Farias dos Santos, Eliel Soares Orenha, and Silvia Helena de Carvalho Sales-Peres. "Coronavirus Disease 2019 Biological Risk and Clinical Care Protocol in Dentistry: A Systematic Review." Acta Scientific Dental Scienecs 5, no. 5 (April 8, 2021): 28–43. http://dx.doi.org/10.31080/asds.2021.05.1094.

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Bose, Sreekanth. "Common Risk Factor Approach for Oral Diseases- A SWOT Analysis." Acta Scientific Dental Scienecs 3, no. 9 (August 8, 2019): 07–09. http://dx.doi.org/10.31080/asds.2019.03.0611.

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Tareq Abdulrazzaq, Ahmed, Tamara Sami, Ahmed Hammad, Suhail I Al-Gburi, and Farked Najim. "Effects of Systemic Diseases on Biological Tooth Movement: A Review." Acta Scientific Dental Scienecs 4, no. 6 (May 29, 2020): 54–58. http://dx.doi.org/10.31080/asds.2020.04.0849.

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Cherry-Peppers, Gail, Andrea D Jackson, Cheryl Fryer, Candice Mitchell, Xinbin Gu, Dana C Jackson, Robert Gamble, et al. "The Efficacy of Medical Consultation to Improve Oral Health Outcomes in Patients with Sickle Cell Disease." Acta Scientific Dental Scienecs 5, no. 1 (November 28, 2020): 130–35. http://dx.doi.org/10.31080/asds.2020.05.1012.

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XIONG, Z., G. PIGNATARO, M. LI, S. CHANG, and R. SIMON. "Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases." Current Opinion in Pharmacology 8, no. 1 (February 2008): 25–32. http://dx.doi.org/10.1016/j.coph.2007.09.001.

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J, Sheehama, Mwadinohamba I, and Lukolo L. "Prevalence of Dental and Oral Diseases in People Living with HIV, A Systematic Review." Acta Scientific Dental Scienecs 4, no. 12 (November 30, 2020): 98–102. http://dx.doi.org/10.31080/asds.2020.04.0989.

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Abdul-Majeed, Shakila, and Surya M. Nauli. "Polycystic Diseases in Visceral Organs." Obstetrics and Gynecology International 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/609370.

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Primary cilia are nonmotile, microtubule-based, antenna-like organelles projecting from the apical surface of most mammalian cells. Elegant studies have established the importance of ciliary structure and function in signal transduction and the sensory roles of cilia in maintaining healthy cellular state. In particular, dysfunctional cilia have been implicated in a large number of diseases mainly characterized by the presence of fluid-filled cysts in various organs. Aside from polycystic kidney disease (PKD), however, the roles of cilia in polycystic liver disease (PLD), polycystic pancreas disease (PPD), and polycystic ovarian syndrome (PCOS) are still very vague. In addition, although gender and sex hormones are known to regulate cyst formation, their roles in regulating physiological functions of cilia need to be further explored.

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22

Du, M., R. Nair, L. Jamieson, Z. Liu, and P. Bi. "Incidence Trends of Lip, Oral Cavity, and Pharyngeal Cancers: Global Burden of Disease 1990–2017." Journal of Dental Research 99, no. 2 (December 24, 2019): 143–51. http://dx.doi.org/10.1177/0022034519894963.

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The worldwide incidence trends of the lip, oral cavity, and pharyngeal cancers (LOCPs) need to be updated. This study aims to examine the temporal incidence trends of LOCPs from 1990 to 2017, using the latest Global Burden of Disease (GBD) study data to explore sex, age, and regional differences. GBD incidence data for LOCPs were driven by population cancer registries and were estimated from mortality data. Age-standardized incidence rates (ASIRs) were directly extracted from the 2017 GBD database to calculate the estimated annual percentage change (EAPC) over the study period. Incidence trends are mapped and compared separately by sex (females vs. males), age groups (15–49, 50–69, and 70+ y), regions (21 geographical and 5 sociodemographic regions), and countries. Among 678,900 incident cases of LOCPs notified in 2017, more than half were lip and oral cavity cancers. From 1990 to 2017, the estimated global incidence for nasopharyngeal cancers decreased dramatically (EAPC = −1.52; 95% confidence interval [CI], –1.70 to −1.34), while the incidence for lip and oral cavity cancers (EAPC = 0.26; 95% CI, 0.16–0.37) and other pharyngeal cancers (EAPC = 0.62; 95% CI, 0.54–0.71) increased. Higher ASIRs were observed among males than females across all age groups. However, females had larger EAPC variation when compared to males. Population groups aged 15 to 49 y presented the lowest ASIRs, with larger values of EAPC than those aged 50 to 69 and 70+ y. While high-income countries had higher ASIRs with little EAPC variation, ASIRs varied across low/middle-income regions with larger EAPC variations. South Asia and East Asia had the highest ASIRs and EAPC for lip and oral cavity cancers, respectively. In conclusion, the global incidence of LOCPs has increased among females, those aged 15 to 49 y, and people from low/middle-income countries over the study period, excepting nasopharyngeal cancers, which had a decreasing worldwide trend.

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Issrani, Rakhi. "Referral Pathway for Management of Oral Diseases- Creating Care Pathways with A Smile..... For A Smile." Acta Scientific Dental Scienecs 3, no. 10 (September 23, 2019): 67–68. http://dx.doi.org/10.31080/asds.2019.03.0648.

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Gains, Malcolm J., and Andrea C. LeBlanc. "Canadian Association of Neurosciences Review: Prion Protein and Prion Diseases: The Good and the Bad." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 34, no. 2 (May 2007): 126–45. http://dx.doi.org/10.1017/s0317167100005953.

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In the 1700's a strange new disease affecting sheep was recognized in Europe. The disease later became known as “Scrapie” and was the first of a family of similar diseases affecting a number of species that are now known as the Transmissible Spongiform Encephalopathies (TSEs). The appearance of a new disease in humans linked to the consumption of meat products from infected cattle has stimulated widespread public concern and scientific interest in the prion protein and related diseases. Nearly 300 years after the first report, these diseases still merit the descriptor “strange”. This family of diseases is characterized by a unique profile of histological changes, can be transmitted as inherited or acquired diseases, as well as apparent sporadic spontaneous generation of the disease. These diseases are believed by many, to be caused by a unique protein only infectious agent. The “prion protein” (PrPC), a term first coined by Stanley Prusiner in 1982 is crucial to the development of these diseases, apparently by acting as a substrate for an abnormal disease associated form. However, aside from being critical to the pathogenesis of the disease, the function of PrPC, which is expressed in all mammals, has defied definitive description. Several roles have been proposed on the basis ofin vitrostudies, however, thus far,in vivoconfirmation has not been forthcoming. The biological features of PrPCalso seem to be unusual. Numerous mouse models have been generated in an attempt to understand the pathogenesis of these diseases. This review summarizes the current state of histological features, the etiologic agent, the normal metabolism and the function of the prion protein, as well as the limitations of the mouse models.

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Ksiazek, Thomas G., Paul A. Rota, and Pierre E. Rollin. "A review of Nipah and Hendra viruses with an historical aside." Virus Research 162, no. 1-2 (December 2011): 173–83. http://dx.doi.org/10.1016/j.virusres.2011.09.026.

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Kweon, Hae-Jin, and Byung-Chang Suh. "Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation." BMB Reports 46, no. 6 (June 30, 2013): 295–304. http://dx.doi.org/10.5483/bmbrep.2013.46.6.121.

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Mitchell, Brett, Chris Ware, Alistair McGregor, Saffron Brown, Anne Wells, Rhonda L. Stuart, Fiona Wilson, and Matthew Mason. "ASID (HICSIG)/AICA Position Statement: Preventing catheter-associated urinary tract infections in patients." Healthcare infection 16, no. 2 (June 2011): 45–52. http://dx.doi.org/10.1071/hi11007.

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Baxter, A. J., T. S. Brugha, H. E. Erskine, R. W. Scheurer, T. Vos, and J. G. Scott. "The epidemiology and global burden of autism spectrum disorders." Psychological Medicine 45, no. 3 (August 1, 2014): 601–13. http://dx.doi.org/10.1017/s003329171400172x.

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BackgroundAutism spectrum disorders (ASDs) are persistent disabling neurodevelopmental disorders clinically evident from early childhood. For the first time, the burden of ASDs has been estimated for the Global Burden of Disease Study 2010 (GBD 2010). The aims of this study were to develop global and regional prevalence models and estimate the global burden of disease of ASDs.MethodA systematic review was conducted for epidemiological data (prevalence, incidence, remission and mortality risk) of autistic disorder and other ASDs. Data were pooled using a Bayesian meta-regression approach while adjusting for between-study variance to derive prevalence models. Burden was calculated in terms of years lived with disability (YLDs) and disability-adjusted life-years (DALYs), which are reported here by world region for 1990 and 2010.ResultsIn 2010 there were an estimated 52 million cases of ASDs, equating to a prevalence of 7.6 per 1000 or one in 132 persons. After accounting for methodological variations, there was no clear evidence of a change in prevalence for autistic disorder or other ASDs between 1990 and 2010. Worldwide, there was little regional variation in the prevalence of ASDs. Globally, autistic disorders accounted for more than 58 DALYs per 100 000 population and other ASDs accounted for 53 DALYs per 100 000.ConclusionsASDs account for substantial health loss across the lifespan. Understanding the burden of ASDs is essential for effective policy making. An accurate epidemiological description of ASDs is needed to inform public health policy and to plan for education, housing and financial support services.

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Sordo, Lorena, Craig Breheny, Vicky Halls, Amy Cotter, Camilla Tørnqvist-Johnsen, Sarah M. A. Caney, and Danièlle A. Gunn-Moore. "Prevalence of Disease and Age-Related Behavioural Changes in Cats: Past and Present." Veterinary Sciences 7, no. 3 (July 6, 2020): 85. http://dx.doi.org/10.3390/vetsci7030085.

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(1) Background: age-related changes in behaviour and health may be thought of as “normal” ageing; however, they can reflect under-diagnosed, potentially treatable, conditions. This paper describes the prevalence of age-related behavioural changes and disease in two UK cat populations at separate time-points. (2) Methods: owners of cats aged ≥11 years completed questionnaires in 1995 (cohort 1: n = 1236), and from 2010–2015 (cohort 2: n = 883). (3) Results: the most important behavioural changes in these cats were increased affection towards their owners (reported by 51.9% in 1995; 35.8% in 2010–2015), increased vocalisation (63.5%; 58.9%, respectively), particularly at night (32%; 43.6%), and house-soiling (29.3%; 55.8%). Most (79.4%; 81%) of the cats had visited a veterinary surgeon since becoming 11 years old. The main reasons, aside from vaccinations, were dental disease, renal disease and lower urinary tract disorders in 1995, and dental disease, renal disease and hyperthyroidism in 2010–2015. All major diagnoses were reported significantly more frequently in 2010–2015 than in 1995; behavioural changes were variably associated with these diseases. (4) Conclusion: elderly cats display age-related behavioural changes and develop diseases that may be under-diagnosed. Veterinarians need to ask owners about these behavioural changes, as they may signify manageable conditions rather than reflect “normal” ageing.

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Storozhuk, Maksim, Andrii Cherninskyi, Oleksandr Maximyuk, Dmytro Isaev, and Oleg Krishtal. "Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain." Current Neuropharmacology 19, no. 9 (September 14, 2021): 1570–89. http://dx.doi.org/10.2174/1570159x19666210125151824.

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Acid-sensing ion channels (ASICs) are Na+-permeable ion channels activated by protons and predominantly expressed in the nervous system. ASICs act as pH sensors leading to neuronal excitation. At least eight different ASIC subunits (including ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, ASIC4, ASIC5) are encoded by five genes (ASIC1-ASIC5). Functional ASICs assembled in the plasma membrane are homo- or heteromeric trimers. ASIC1a-containing trimers are of particular interest as, in addition to sodium ions, they also conduct calcium ions and thus can trigger or regulate multiple cellular processes. ASICs are widely but differentially expressed in the central and peripheral nervous systems. In the mammalian brain, a majority of neurons express at least one ASIC subunit. Several recent reviews have summarized findings of the role of ASICs in the peripheral nervous system, particularly in nociception and proprioception, and the structure-function relationship of ASICs. However, there is little coverage on recent findings regarding the role of ASICs in the brain. Here we review and discuss evidence regarding the roles of ASICs: (i) as postsynaptic receptors activated by protons coreleased with glutamate at glutamatergic synapses; (ii) as modulators of synaptic transmission at glutamatergic synapses and GABAergic synapses; (iii) in synaptic plasticity, memory and learning; (iv) in some pathologies such as epilepsy, mood disorders and Alzheimer's disease.

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Keizman, D., P. Huang, M. A. Eisenberger, R. Pili, J. J. Kim, H. J. Hammers, and M. A. Carducci. "Effect of angiotenstin system inhibitors (ASIs) on the outcome of sunitinib treatment (tx) in patients (pts) with metastatic renal cell carcinoma (mRCC)." Journal of Clinical Oncology 29, no. 7_suppl (March 1, 2011): 317. http://dx.doi.org/10.1200/jco.2011.29.7_suppl.317.

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317 Background: The VEGFR inhibitor sunitinib is a standard tx for mRCC. ASIs include angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs). ASIs are used in the tx of hypertension (HTN), kidney disease, and heart failure. Preclinical and clinical studies in several cancer types have shown that they may inhibit tumor growth. Their effect on the outcome of sunitinib in mRCC is poorly defined. Aims: to study the effect of ASIs on the outcome sunitinib tx for mRCC. Methods: We performed a retrospective study of an unselected cohort of pts with mRCC, who were treated with 50 mg of oral sunitinib in cycles of 4 weeks followed by 2 weeks of rest. Pts were divided into 2 groups: (1) ASIs users and (2) ASIs naive. The effect of ASIs use on objective response, time to progression (TTP), and overall survival (OS), was tested with adjustment of other known confounding risk factors using a chisquare test and partial likelihood test from cox model. Results: Between 2004–2010, 124 pts with mRCC were treated with sunitinib. There were 44 ASIs users (group 1) and 80 nonusers (group 2). With regard to sunitinib tx initiation time, 39 users started ASIs before, 3 within 1 month, and 2 after 5 months. The groups were balanced regarding the following known clinical prognostic factors: past nephrectomy, RCC histology, time from diagnosis to tx, ≥ 2 metastatic sites, lung/liver/bone metastasis, ECOG performance status, Hb level, corrected ca > 10 mg/dL, platelets count, prior cytokines/ targeted tx, sunitinib induced HTN, % pts that had dose reduction/tx interruption, and mean dose/cycle. Objective response in group 1 vs. 2 was partial response (PR) 48% vs 38% (p=0.24), stable disease (SD) 38% both, and progressive disease (PD) 14% vs. 24% (p=0.19). Median TTP was 12 vs. 6 ms (HR 0.635 in ASIs users, p=0.034). Median OS was 25 vs. 22 ms (p=0.3). Conclusions: ASIs may improve the outcome of pts with mRCC that are treated with sunitinib. This should be investigated prospectively, and if validated, applied in clinical practice and clinical trials. No significant financial relationships to disclose.

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Smith, Donalda M. "Health and Disease in Farm Workers." Outlook on Agriculture 15, no. 3 (September 1986): 115–20. http://dx.doi.org/10.1177/003072708601500303.

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Occupational diseases, such as silicosis in miners, are widespread but it is only comparatively recently that they have received the serious attention they demand. Leaving aside accidents associated with machinery and agrochemicals, farm workers are particularly liable to a large number of health hazards – physical, chemical, and biological. The nature of the industry – small groups of workers often employed in remote places under primitive conditions – makes it difficult to assess the real incidence of work-associated diseases and to organise effective treatment and preventive measures.

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JENKYN, J. F., R. J. GUTTERIDGE, and A. D. TODD. "A comparison of management regimes for one-year rotational set-aside within a sequence of winter wheat crops, and of growing wheat without interruption. 3. Effects on diseases." Journal of Agricultural Science 130, no. 4 (June 1998): 399–410. http://dx.doi.org/10.1017/s0021859698005450.

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Different management regimes for 1-year rotational set-aside were tested in three experiments that followed winter wheat and started in autumn 1988–90. The regimes included operations that prevented the establishment of volunteers or allowed them to establish and persist until either spring or summer, and also altered the distribution of debris from the winter wheat that preceded the set-aside. For comparison, treatments in the set-aside year also included winter wheat.Samples taken in spring from the first test crop showed that there were few significant or consistent effects on leaf diseases of growing the wheat after different set-aside treatments or after winter wheat. There were significant effects of the set-aside treatments on root and stem base diseases but some of the effects, and the apparent absence of others, are not easily reconciled with current understanding of the biology of the pathogens concerned. In summer, eyespot (Pseudocercosporella herpotrichoides) was most severe after winter wheat and least severe after ryegrass. Severity after the other set-aside treatments did not differ significantly. There was more sharp eyespot (Rhizoctonia cerealis) in plots that had been ploughed at the start of the set-aside year, including those sown with winter wheat, than in those that had not. Brown foot rot (Fusarium spp.) was equally severe where the wheat followed wheat or where it followed set-aside treatments that allowed volunteers to develop, and less so where the development of volunteers was prevented. Take-all (Gaeumannomyces graminis var. tritici) was most severe after winter wheat and more severe after set-aside treatments that allowed volunteers to develop and survive through the winter than after those that did not. Effects of ryegrass (Lolium perenne ssp. multiflorum) on take-all in the following wheat were particularly variable, perhaps because ryegrass is a host of both the take-all fungus and of Phialophora graminicola, one of its principal antagonists.

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Huu Ban, Nguyen, Dao Anh Son, Vu Manh Tuan, and Nguyen Thi Thuy Hanh. "Current Situation of Oral Diseases Among Police Officers and Soldiers of Nam Dinh Provincial Public Security Department in Vietnam, in 2019-2020: Examination, Diagnosis and Intervention with Some Biomedical Techniques." Acta Scientific Dental Scienecs 5, no. 2 (January 31, 2021): 92–98. http://dx.doi.org/10.31080/asds.2020.05.1026.

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Roy, Debendra. "ACID SENSING ION CHANNELS (ASICS): POTENTIAL TARGETS FOR THE DISCOVERY OF NOVEL THERAPEUTICS IN DISEASE MANAGEMENT." International Journal of Clinical and Biomedical Research 4, no. 1 (2018): 62. http://dx.doi.org/10.5455/ijcbr.2018.41.13.

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Welder, Jeffrey David, Pejman Bakhtiari, and Ali R. Djalilian. "Limbitis Secondary to Autologous Serum Eye Drops in a Patient with Atopic Keratoconjunctivitis." Case Reports in Ophthalmological Medicine 2011 (2011): 1–3. http://dx.doi.org/10.1155/2011/576521.

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Purpose. Report a case of limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis.Design. Interventional case report.Methods. A 32-year-old African American female with atopic keratoconjunctivitis (AKC) presented with chronic dry eye and diffuse punctate epithelial erosions refractory to conservative treatment. She was initially managed with cyclosporine ophthalmic 0.05% in addition to preservative-free artificial tears and olopatadine hydrochloride 0.2% for 6 months. She was later placed on autologous serum eye drops (ASEDs) and 4 weeks into treatment developed unilateral limbitis. The limbitis resolved shortly after stopping ASEDs in that eye; however, the drops were continued in the contralateral eye, which subsequently developed limbitis within 2 weeks. ASEDs were discontinued in both eyes, and the patient has remained quiet ever since.Results. Patient with a history of AKC and no prior history of limbitis developed limbitis shortly after starting ASEDs, which resolved promptly after discontinuation of therapy with no subsequent recurrence of inflammation.Conclusion. ASEDs are widely used in the treatment of complicated or treatment refractory dry eye. The potential side effects should be kept in mind when prescribing ASEDs for any patient, especially in those with underlying immunological diseases and circulating inflammatory factors.

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Stuart, Rhonda L., Caroline Marshall, Mary-Louise McLaws, Claire Boardman, Philip L. Russo, Glenys Harrington, and John K. Ferguson. "ASID/AICA position statement – Infection control guidelines for patients with Clostridium difficile infection in healthcare settings." Healthcare infection 16, no. 1 (March 2011): 33–39. http://dx.doi.org/10.1071/hi11011.

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Novak, Valentina, Boris Rogelj, and Vera Župunski. "Therapeutic Potential of Polyphenols in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia." Antioxidants 10, no. 8 (August 23, 2021): 1328. http://dx.doi.org/10.3390/antiox10081328.

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Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are severe neurodegenerative disorders that belong to a common disease spectrum. The molecular and cellular aetiology of the spectrum is a highly complex encompassing dysfunction in many processes, including mitochondrial dysfunction and oxidative stress. There is a paucity of treatment options aside from therapies with subtle effects on the post diagnostic lifespan and symptom management. This presents great interest and necessity for the discovery and development of new compounds and therapies with beneficial effects on the disease. Polyphenols are secondary metabolites found in plant-based foods and are well known for their antioxidant activity. Recent research suggests that they also have a diverse array of neuroprotective functions that could lead to better treatments for neurodegenerative diseases. We present an overview of the effects of various polyphenols in cell line and animal models of ALS/FTD. Furthermore, possible mechanisms behind actions of the most researched compounds (resveratrol, curcumin and green tea catechins) are discussed.

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WANG, MINGBANG, XIAOMEI FAN, TAO WANG, and JINYU WU. "High-throughput sequencing of autism spectrum disorders comes of age." Genetics Research 95, no. 4 (August 2013): 121–29. http://dx.doi.org/10.1017/s0016672313000153.

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SummaryAutism spectrum disorders (ASDs) are lifelong neurodevelopmental disabilities that affect 1 in 88 children in the USA. Despite the high heritability, the genetic basis for a majority of the ASDs remains elusive. The considerable clinical and genetic heterogeneity pose a significant challenge technically. State-of-the-art high-throughput sequencing (HTS), which makes the analyses of any specific single/multiple genes or whole exomes feasible, has shown a promising perspective in disease gene discovery. To date, numerous genetic studies using HTS have been reported and many rare inherited or de novo mutations have been identified. This review will focus on the progress and prospective of genome studies of ASDs using HTS.

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Montalbano, Giuseppe, Maria Levanti, Kamel Mhalhel, Francesco Abbate, Rosaria Laurà, Maria Cristina Guerrera, Marialuisa Aragona, and Antonino Germanà. "Acid-Sensing Ion Channels in Zebrafish." Animals 11, no. 8 (August 23, 2021): 2471. http://dx.doi.org/10.3390/ani11082471.

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The ASICs, in mammals as in fish, control deviations from the physiological values of extracellular pH, and are involved in mechanoreception, nociception, or taste receptions. They are widely expressed in the central and peripheral nervous system. In this review, we summarized the data about the presence and localization of ASICs in different organs of zebrafish that represent one of the most used experimental models for the study of several diseases. In particular, we analyzed the data obtained by immunohistochemical and molecular biology techniques concerning the presence and expression of ASICs in the sensory organs, such as the olfactory rosette, lateral line, inner ear, taste buds, and in the gut and brain of zebrafish.

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Rathnayake, G. I., and M. R. Sooriyarachchi. "Automated Statistical Information System (ASIS) for Diagnosis and Prognosis of Life-threatening Viral Diseases." Sri Lankan Journal of Applied Statistics 15, no. 3 (December 15, 2014): 185. http://dx.doi.org/10.4038/sljastats.v15i3.7796.

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Di Nanni, Noemi, Matteo Bersanelli, Francesca Anna Cupaioli, Luciano Milanesi, Alessandra Mezzelani, and Ettore Mosca. "Network-Based Integrative Analysis of Genomics, Epigenomics and Transcriptomics in Autism Spectrum Disorders." International Journal of Molecular Sciences 20, no. 13 (July 9, 2019): 3363. http://dx.doi.org/10.3390/ijms20133363.

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Current studies suggest that autism spectrum disorders (ASDs) may be caused by many genetic factors. In fact, collectively considering multiple studies aimed at characterizing the basic pathophysiology of ASDs, a large number of genes has been proposed. Addressing the problem of molecular data interpretation using gene networks helps to explain genetic heterogeneity in terms of shared pathways. Besides, the integrative analysis of multiple omics has emerged as an approach to provide a more comprehensive view of a disease. In this work, we carry out a network-based meta-analysis of the genes reported as associated with ASDs by studies that involved genomics, epigenomics, and transcriptomics. Collectively, our analysis provides a prioritization of the large number of genes proposed to be associated with ASDs, based on genes’ relevance within the intracellular circuits, the strength of the supporting evidence of association with ASDs, and the number of different molecular alterations affecting genes. We discuss the presence of the prioritized genes in the SFARI (Simons Foundation Autism Research Initiative) database and in gene networks associated with ASDs by other investigations. Lastly, we provide the full results of our analyses to encourage further studies on common targets amenable to therapy.

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Tanaka, Ruriko, Junya Kuroda, Eishi Ashihara, Takayuki Ishikawa, Tomohiko Taki, Mitsuharu Hirai, Satoshi Majima, Masafumi Taniwaki, Taira Maekawa, and Shinya Kimura. "Detection of the V617F Mutation of JAK2 Using a Novel Fully Automated SNP Super-Rapid Detector." Blood 110, no. 11 (November 16, 2007): 4640. http://dx.doi.org/10.1182/blood.v110.11.4640.4640.

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Abstract The JAK2 V617F substitution mutation (JAK2V617F) is one of the genetic hallmarks of chronic myeloproliferative diseases (CMPDs), such as polycythemia vera (PV), essential thrombocythemia (ET), or chronic idiopathic myelofibrosis (CIMF). Accurate and rapid detection of this mutation is essential for diagnosing and treating CMPDs today. We have developed a novel, rapid, sensitive and fully-automated single nucleotide polymorphism (SNP) detection system, termed ARKRAY SNP Detection System (ASDS), and used it to detect JAK2V617F in patients with CMPDs. With ASDS, diagnosis requires only 100ml of whole blood (or DNA), and the system automatically performs DNA extraction and PCR. The detection of both wild type and mutant jak2 alleles from PCR amplicons was measured by the increase in fluorescence produced by the dissociation of a JAK2V617F-specific guanine-quenching probe, and was completed within 75 minutes. In dilution assays of HEL cells (a JAK2V617F-positive leukemia cell line) using MYL cells (a chronic myelogenous leukemia (CML)-derived cell line with wild type JAK2), the system reliably quantified the mutation in a cell population containing as few as 1.0% mutant cells (Figure). We tested 44 samples from CMPDs patients using ASDS and direct sequencing (DS) (13 PV, 23 ET, 3 CIMF, 1 chronic myelomonocytic leukemia (CMMoL), 1 chronic neutrophilic leukemia (CNL), 3 unclassifiable CMPD (uCMPD)), which included samples from 3 post-allogenic bone marrow transplantation (BMT) patients with CIMF or uCMPD. Using ASDS, we detected JAK2V617F in 12/13 PV, 13/23 ET, 0/1 CIMF without BMT, 1/1 CMMoL, 0/1 CNL and 1/3 uCMPD. Overall, these results were comparable to previous results using relatively sensitive detection strategies, such as allele-specific PCR (AS-PCR). One of the 3 post-BMT CIMF samples was positive for JAK2V617F, which indicated that there were residual disease clones after BMT. ASDS detected JAK2V617F in one PV and eight ET patients, while DS failed to detect the mutation in these same samples, which clearly indicated that ASDS has a higher sensitivity than DS. JAK2V617F was absent in all samples from secondary erythrocytemia and healthy volunteers. Collectively, these results demonstrate that ASDS is a powerful and convenient tool for detecting JAK2V617F. With its associated high sensitivity, convenience and rapidity, this system will enable “Point-of-care” testing in clinical laboratories and “Patient-oriented” therapy for CMPDs. ASDS could also be applied to the detection of other point mutations relevant to cancer treatment, such as mutations in the BCR-ABL kinase domain that are associated with CML. Figure Figure

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Siniscalco, Dario, Anna Sapone, Alessandra Cirillo, Catia Giordano, Sabatino Maione, and Nicola Antonucci. "Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?" Journal of Biomedicine and Biotechnology 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/480289.

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Autism and autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders. They are enigmatic conditions that have their origins in the interaction of genes and environmental factors. ASDs are characterized by dysfunctions in social interaction and communication skills, in addition to repetitive and stereotypic verbal and nonverbal behaviours. Immune dysfunction has been confirmed with autistic children. There are no defined mechanisms of pathogenesis or curative therapy presently available. Indeed, ASDs are still untreatable. Available treatments for autism can be divided into behavioural, nutritional, and medical approaches, although no defined standard approach exists. Nowadays, stem cell therapy represents the great promise for the future of molecular medicine. Among the stem cell population, mesenchymal stem cells (MSCs) show probably best potential good results in medical research. Due to the particular immune and neural dysregulation observed in ASDs, mesenchymal stem cell transplantation could offer a unique tool to provide better resolution for this disease.

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Minakova, V. "MARKERS LEVEL OF ENDOTHELIAL DYSFUNCTION (ENDOTELIN-1 AND NITROGEN OXIDE) IN BLOOD SYROVISTS AND ALBUMINURIA IN CHILDREN WITH ERYTHROCYTURIA." Ukrainian Journal of Nephrology and Dialysis, no. 3(55) (December 12, 2017): 49–54. http://dx.doi.org/10.31450/ukrjnd.3(55).2017.05.

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The aim of our study was to investigate the levels of endothelin-1 and aside nitrogen in the serum of children with kidney diseases that clinically present with hematuria syndrome. Materials and methods: a total of 158 children aged 1 to 18 years with kidney disease, having a course with hematuria. Patients were divided into 3 groups: group 1 – glomerulonephritis; group 2 – hereditary nephritis; group 3 – dismetabolic nephropathy. It was studied the level of endothelin, nitric oxide in serum, the level of hematuria, AU in urine, blood biochemistry, glomerular filtration. Results: the highest level of ET-1 was detected in patients with glomerulonephritis - 0,82±0.055 fmol/ml, with the variation range from 0.10 to 3.2 fmol/ml, which twice exceeded the mean values in the control group, whereas the growth rate of hereditary nephritis and DN was more moderate (0,64±0,063 and 0,54±0,072 fmol/ml, respectively). The NO level increased significantly in patients with glomerulonephritis to 120,2±12,3 μmol/l. Conclusions. Determining the level of ET-1 and NO in the serum of children with kidney diseases, having a course with hematuria, gives the opportunity to get an idea about the presence of endothelium dysfunction. Indicators of endothelial dysfunction can be used as markers of severity and progression of the disease.

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Lange, Kezia J., and Melvin G. McInnis. "Studies of Anticipation in Bipolar Affective Disorder." CNS Spectrums 7, no. 3 (March 2002): 196–202. http://dx.doi.org/10.1017/s1092852900017569.

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ABSTRACTAnticipation refers to the increase in disease severity or decrease in age of onset in successive generations. The concept evolved from the theories and dogma of degeneration that were pervasive in psychiatry and medicine in the late 19th century and into the early 20th century. The term was set aside with the criticism of geneticist Lionel Penrose, who argued that anticipation was the result of ascertainment biases. The renewed interest in anticipation followed the identification of its molecular genetic basis in the form of unstable trinucleotide repeats. Subsequently, several diseases have been studied clinically for the presence of anticipation. Although anticipation has been identified in many diseases, including bipolar disorder, only diseases showing a pattern of progressive neurodegeneration have been associated with unstable trinucleotide repeats. This review summarizes the research on anticipation in bipolar disorder and other secular trends in the patterns of the illness such as the cohort effect. The changing nature of bipolar disorder is likely to be a result of combined influences from several genes, some of which are likely to be in a state of flux, as well as environmental or cultural forces that converge to give the clinical picture of anticipation.

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Noureldine, H. A., W. Nour-Eldine, M. H. Hodroj, M. H. A. Noureldine, A. Taher, and I. Uthman. "Hematological malignancies in connective tissue diseases." Lupus 29, no. 3 (January 14, 2020): 225–35. http://dx.doi.org/10.1177/0961203319899986.

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Chronic inflammation has profound tumor-promoting effects. Inflammatory cells are the key players in immunosurveillance against tumors, and immunosuppression is known to increase the risk of tumors. Autoimmune diseases, which manifest as loss of self-tolerance and chronic immune dysregulation, provide a perfect environment for tumor development. Aside from managing the direct inflammatory consequences of autoimmune pathogenesis, cancer risk profiles should be considered as a part of a patient's treatment. In this review, we describe the various associations of malignancies with autoimmune diseases, specifically systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and Sjögren's syndrome, as well as discuss the mechanisms contributing to the pathogenesis of both disorders.

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James, Paula D., David Lillicrap, and Pier M. Mannucci. "Alloantibodies in von Willebrand disease." Blood 122, no. 5 (August 1, 2013): 636–40. http://dx.doi.org/10.1182/blood-2012-10-462085.

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Abstract The development of alloantibodies against von Willebrand factor (VWF) represents a rare but serious complication of treatment of von Willebrand disease (VWD), occurring in ∼5% to 10% of type 3 VWD patients. Affected patients can present with a range of symptoms, including lack or loss of hemostatic response to infused VWF concentrates up to anaphylactic reactions in rare cases. It is classically reported in multitransfused patients and occurs most frequently in patients with partial or complete VWF gene deletions. A positive family history of anti-VWF antibodies also appears to be a risk factor. There is a lack of standardization of laboratory methods for antibody identification and characterization. Issues of variability in laboratory approaches as well as the rarity of the complication act as a barrier to future studies. Recombinant factor VIII as well as bypassing agents and immune tolerance have been reported as effective treatments; however, aside from case reports, little exists in the literature to guide management. The imminent clinical availability of recombinant VWF has prompted a resurgence of interest in this area. Additional study is warranted to address the deficiencies in our understanding of this treatment complication.

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Wahidin, Mugi, Fiona Kong, and Hadi Safaat. "POST TSUNAMI IMPACT ON HYPERTENSION AND DIABETES MELLITUS CASES IN PANDEGLANG DISTRICT, BANTEN, INDONESIA." Jurnal Berkala Epidemiologi 8, no. 3 (September 20, 2020): 208. http://dx.doi.org/10.20473/jbe.v8i32020.208-217.

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Background: Pandeglang, a district in Banten province, Indonesia, was the worst affected area of the Sunda Strait tsunami which occurred on 22nd December, 2018. Aside from threats of communicable disease outbreaks, the district faced the challenges of managing non-communicable diseases (NCD) in the community. Purpose: The aim of the study is to describe the post tsunami impact on cases of hypertension and diabetes mellitus and the expected one-year projections of these diseases in the district of Pandeglang, Banten. Methods: In January 2019, we collected primary data from Pandeglang District Health Office (DHO) and 15 Public Health Centres (PHCs) that were heavily affected by the tsunami. Surveillance officers were also interviewed for their subjective opinions on disease projections in both the DHO and PHCs. Aggregated data of cases presenting to the PHCs for assistance were analysed in relation to the post tsunami period. The diseases of interest included hypertension and diabetes mellitus. Results: Reported cases of hypertension and diabetes mellitus increased a few days after the tsunami. For hypertension, the cases spiked on the 5th and 8th days, but for diabetes mellitus the spike came much later. Average cases of hypertension and diabetes mellitus per PHC were 62 and 3, respectively. At district and PHC level, hypertension and diabetes mellitus were considered as minor contributing factors to the morbidity and mortality in the affected communities. The projection of these diseases was optimistic after the first month. Conclusion: It can be concluded that the volume of cases with hypertension and diabetes in the district of Pandeglang tended to be in the first few weeks post tsunami These diseases are projected to lessen in the second month after the disaster due to the recovery of local health services.

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Aggarwal, Diwakar, Sushil K. Upadhyay, Raj Singh, and Hardeep S. Tuli. "Recent patents on therapeutic activities of xanthohumol: a prenylated chalconoid from hops (Humulus lupulus L.)." Pharmaceutical Patent Analyst 10, no. 1 (January 2021): 37–49. http://dx.doi.org/10.4155/ppa-2020-0026.

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There is expanding proof that specific natural compounds found in plants have additional conventional medicinal properties. One such compound is xanthohumol (XN), which is being explored as an antimicrobial, anticarcinogenic, antidiabetic and anti-inflammatory agent – aside from its utilization in dealing with conditions like autism, bone and skin improvement and microbial infections, lipid-related illnesses, and so on. XN is reported to suppress the uncontrolled production of inflammatory mediators responsible for diseases including cardiovascular disease, neurodegeneration and tumors. Further, it is accounted to limit adipogenesis and control obesity by focusing on principal adipocyte marker proteins. It is most generally utilized in the brewing industry as an additive and flavoring agent to add bitterness and aroma to beer. Present investigation sum up the patents filed in most recent 2 years on development of different pharmaceutical mixes and strategies dependent on various therapeutic potentials of XN.

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Journal articles on the topic 'ASIDS (Disease)'

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