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Dissertations / Theses on the topic 'Aspergillus fumigatus'

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Published: 4 June 2021
Last updated: 25 July 2025

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1

Weaver, Sean. "Heterokaryon incompatibility in Aspergillus fumigatus." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/heterokaryon-incompatibility-in-aspergillus-fumigatus(c0db26be-8326-4a93-8bcb-2648069e256c).html.

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Invasive aspergillosis (IA) is associated with high mortality rates and can be difficult and expensive to treat with current drugs. The drugs used to treat IA are also associated with undesirable, and often severe, side-effects of the patient. The main causative agent of this disease is the opportunistic pathogen Aspergillus fumigatus. This study identifies genes which play a role in a fungal-specific type of programmed cell death (PCD) in A. fumigatus, known as heterokaryon incompatibility. The development of drugs specifically targeting the products of these genes could lead to fewer side-ef
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2

Robertson, Maura Diane. "Host defences against Aspergillus fumigatus." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/26892.

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The potential of the filamentous fungus Aspergillus fumigatus to act as an opportunistic pathogen may be related to its ability to resist the host defence network. Whilst phagocytic cells are clearly important in host defences against invading microorganisms their precise role in the killing of A. fumigatus remains undefined. The purpose of this study was to examine the basic interactions between phagocytic cells, from humans and rodents, with spores of A. fumigatus. In particular the mechanisms whereby phagocytic cells bind and kill spores of A. fumigatus, when compared with the relatively no
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3

Philippe, Bruno. "Aspergillose pulmonaire invasive : interactions entre Aspergillus fumigatus et macrophage alvéolaire." Paris 12, 2004. https://athena.u-pec.fr/primo-explore/search?query=any,exact,990003948260204611&vid=upec.

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L'aspergillose pulmonaire invasive (AI) due à Aspergillus fumigatus est une infection grave du malade immunodéprimé. Un modèle murin d'AI a montré que le macrophage alvéolaire (MA) représente la première ligne des défenses pulmonaires innées contre A. Fumigatus. Le killing est lent et fait intervenir les réactifs oxydants. Les corticostéroi͏̈des diminuent les capacités de killing en inhibant la production de réactifs oxydants par les MA. L'analyse du killing de A. Fumigatus par des MA de malades transplantés pulmonaires a montré des résultats similaires aux MA murins. La dose de corticostéroi͏
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4

Philippe, Bruno Latgé Jean-Paul. "Aspergillose pulmonaire invasive interactions entre Aspergillus fumigatus et macrophage alvéolaire /." Créteil : Université de Paris-Val-de-Marne, 2007. http://doxa.scd.univ-paris12.fr:8080/theses-npd/th0394826.htm.

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Thèse de doctorat : Sciences de la vie et de la santé : Paris 12 : 2004.<br>Version électronique uniquement consultable au sein de l'Université Paris 12 (Intranet). Titre provenant de l'écran-titre. Bibliogr. : 305 réf.
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5

Bertout, Sébastien. "Polymophisme génétique de souche d'Aspergillus fumigatus isolées d'aspergilloses pulmonaires au cours d'une étude multicentrique." Montpellier 1, 2000. http://www.theses.fr/2000MON13512.

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6

Leleu, Christopher. "Evaluation du risque lié à l'exposition aérienne à Aspergillus fumigatus." Paris 6, 2012. http://www.theses.fr/2012PA066413.

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Aspergillus fumigatus est un champignon filamenteux pathogène responsable de différentes formes d’infections pulmonaires allergiques sur les sujets immunocompétents et d’infections invasives chez les patients neutropéniques. L’inhalation de spores est le mode habituel de contamination suggérant un rôle majeur de l’environnement dans l’épidémiologie de l’aspergillose. Cependant, la relation entre les concentrations d’Aspergillus dans l’air et la probabilité d’infections ne sont pas connues. Dans cette étude, trois approches complémentaires ont été proposées pour analyser cette relation. In vitr
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7

Bernard-Cardona, Muriel. "Protéines et paroi chez Aspergillus fumigatus." Phd thesis, INAPG (AgroParisTech), 2003. http://tel.archives-ouvertes.fr/tel-00005702.

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La paroi du champignon filamenteux A. fumigalus conditionne la croissance et est responsable du maintien de l'intégrité cellulaire lors de l'infection. Les protéines de la paroi de ce champignon filamenteux n'avaient pas été étudiées jusqu'à présent alors qu'elles semblent jouer un rôle essentiel dans la structuration de la paroi de la levure modèle S. cereviciae. Une approche essentiellement biochimique a permis de caractériser les protéines associées à la paroi de A..fumigatus. La majorité des protéines pariétales chez A. fumigatus sont des protéines solubles. Une seule protéine est relargué
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8

Melloul, Elise. "Aspergillose aviaire : développement d’un modèle d’aspergillose chez la dinde (Meleagris gallopavo) et évaluation de l’efficacité de l’énilconazole." Thesis, Paris Est, 2015. http://www.theses.fr/2015PEST1183/document.

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Aspergillus fumigatus est un agent pathogène respiratoire majeur chez les oiseaux d’ornement comme de production. L’aspergillose qui peut être responsable de mortalités importantes et de chutes de performances est difficile à traiter. Nous avons développé un modèle d’aspergillose aiguë chez le dindonneau en inoculant différents lots d’oiseaux âgés de moins d’une semaine via une aérosolisation intratrachéale de doses croissantes de conidies (105 à 108/animal) en utilisant un MicroSprayer®. Le développement de la masse fongique a été évalué par qPCR, dosage du galactomannane (GM), culture fongiq
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9

Brown, Jeremy Stuart. "Signature tagged-mutagenesis of aspergillus fumigatus." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322287.

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10

Kong, Yun-cheung, and 江潤祥. "Multilocus sequence typing of aspergillus fumigatus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4593972X.

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11

Marsh, Rachael. "Cytochrome P450 studies in Aspergillus fumigatus." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364267.

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12

Rosa, Carla Maria de Gouveia. "Detecção de Aspergillus fumigatus em Hemoculturas." Master's thesis, Faculdade de Farmácia da Universidade do Porto, 2007. http://hdl.handle.net/10216/9491.

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13

SPENTCHIAN, MARC. "Interaction aspergillus fumigatus - laminine : etude preliminaire." Nantes, 1990. http://www.theses.fr/1990NANT016M.

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14

Rosa, Carla Maria de Gouveia. "Detecção de Aspergillus fumigatus em Hemoculturas." Dissertação, Faculdade de Farmácia da Universidade do Porto, 2007. http://hdl.handle.net/10216/9491.

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15

Khoufache, Khaled. "Aspects toxicologiques d'Aspergillus fumigatus sur l'épithélium repiratoire in vitro." Paris 12, 2006. https://athena.u-pec.fr/primo-explore/search?query=any,exact,990002459590204611&vid=upec.

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Le rôle des mycotoxines d'Aspergillus fumigatus sur l'épithélium respiratoire a été peu étudié. Pour étudier ces interactions, nous avons utilisé deux modèles de culture primaire de cellules épithéliales en interface air liquide l'un humain (CENH ou cellules épithéliales nasales humaines), l'autre porcin (CETP ou cellules épithéliales de trachée de porc). Afin d'identifier les mycotoxines d'A. Fumigatus impliquées dans ces interactions, nous avons travaillé à la fois sur la phase organique et sur la phase aqueuse d'un filtrat de culture d'A. Fumigatus. La phase organique des filtrat de culture
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16

Khoufache, Khaled Bretagne Stéphane. "Aspects toxicologiques d'Aspergillus fumigatus sur l'épithélium repiratoire in vitro." Créteil : Université de Paris-Val-de-Marne, 2006. http://doxa.scd.univ-paris12.fr:80/theses/th0245959.pdf.

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17

Haddad, Ziad. "Monozytäre Zellantwort gegen Aspergillus fumigatus Untersuchung der Phagozytose, Genexpression und Peptidpräsentation = Monocytic cell responses to Aspergillus fumigatus /." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980508169.

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18

Frandon, Isabelle. "Actions physiologique et moléculaire de glucocorticoïdes sur Aspergillus fumigatus." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE18006.

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19

Chauvin, David. "Nouvelles stratégies de traitement de l'aspergillose : ciblage d'Aspergillus fumigatus par des anticorps thérapeutiques et ciblage du microenvironnement fongique." Thesis, Tours, 2018. http://www.theses.fr/2018TOUR3310.

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Due au champignon Aspergillus fumigatus, l’aspergillose pulmonaire invasive représente une grave menace pour les individus souffrant d’immunodépression sévère. En parallèle d’un diagnostic manquant de spécificité, les traitements actuels présentent une forte toxicité. Ces travaux se sont dans un premier temps intéressés au développement d’anticorps thérapeutiques dirigés contre les protéines pariétales Chitin ring formation du champignon. Le ciblage de ces protéines impliquées dans la croissance fongique a permis la mise en évidence d’effets modérés in vitro, et ont induit, in vivo, un recrute
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20

Urb, Mirjam. "Mechanisms of «Aspergillus fumigatus» chronic airway disease." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110500.

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Colonization of airways by Aspergillus fumigatus hyphae in immunocompetent patients with chronic lung disease leads to progressive decline in pulmonary function. While a minority of these patients develop a severe allergic response to the fungus, the majority of patients show a decline in lung function and airway hyperreactivity despite the absence of elevated IgE levels, eosinophilia or other evidence of hypersensitivity. Treatment of these non-allergic patients with antifungal drugs improves the symptoms, suggesting that pulmonary complications might be directly caused by A. fumigatus. Th
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21

Leslie, Carolyn Elizabeth. "Studies on clinical isolates of Aspergillus Fumigatus." Thesis, Heriot-Watt University, 1985. http://hdl.handle.net/10399/1653.

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22

Baillie, George Scott. "Characterisation of cytochromes P450 from Aspergillus fumigatus." Thesis, University of Kent, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334500.

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23

Taib, Mariam. "The complex chitinolytic system of 'Aspergillus fumigatus'." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416841.

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24

Rajendran, Ranjith. "Adaptive resistance mechanisms of Aspergillus fumigatus biofilms." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4333/.

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Biofilm formation is one of several significant virulence factors associated with life threatening pulmonary infections in immunocompromised individuals caused by Aspergillus fumigatus. Previous studies have demonstrated phase dependant antifungal activity against A. fumigatus biofilms. Antifungal resistance associated with fungal biofilms is a complex multifactorial phenomenon, and it remains unclear specifically how this manifests itself in A. fumigatus. This study therefore aimed to investigate adaptive resistance mechanisms in A. fumigatus biofilms. Different phases of A. fumigatus biofilm
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25

Pillé, Ariane. "Amyloïdes fonctionnelles du pathogène opportuniste Aspergillus fumigatus." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066696/document.

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Les hydrophobines sont des protéines fongiques caractérisées par leurs propriétés amphipathiques et un motif de quatre ponts disulfures. Leur forme soluble s’auto-assemble aux interfaces hydrophobe/hydrophile pour former une couche amphipatique. Ces protéines sont utilisées par les champignons pour franchir la barrière air/eau, former des hyphes aériennes ou recouvrir les spores les rendant hydrophobes, ce qui facilite leur dispersion dans l’air. L’hydrophobine RodA du pathogène opportuniste Aspergillus fumigatus forme une couche de fibres amyloïdes avec une morphologie en bâtonnets qui recouv
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26

Khatiri, Mariam. "Vergleich zweier PCR-Nachweisverfahren zur Früherkennung einer Aspergillusinfektion bei Hochrisikopatienten manuelle DNA-Extraktion im Vergleich zur automatischen MagNa Pure DNA-Extraktion; konventionelle PCR-ELISA im Vergleich zur LightCycler R -Methode /." [S.l. : s.n.], 2006.

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27

Bart-Delabesse, Emmanuelle. "Développement d'un système de typage d'Aspergillus fumigatus au moyen de microsatellites polymorphe : implications écologiques et épidémiologiques." Paris 12, 1999. http://www.theses.fr/1999PA120046.

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L'aspergillose invasive (ai) due a aspergillus fumigatus est devenue une cause majeure de deces chez les patients immunodeprimes. La pathogenese et l'epidemiologie de cette mycose opportuniste sont mal connues, ce qui rend sa prevention particulierement difficile. Devant le manque de fiabilite et/ou de rapidite des methodes de typage actuelles, un systeme de differenciation infraspecifique d'aspergillus fumigatus a ete developpe, au moyen de microsatellites. Le polymorphisme de 4 sequences riches en (ca), issues d'une banque genomique criblee avec un oligonucleotide (ca) 1 0, a ete evalue par
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28

Burc, Laurence. "Suivi épidémiologique des "Aspergillus" pathogènes dans les services d'hématologie et de réanimation pneumologique à l'hôpital Beaujon : typage moléculaire de souches d'"Aspergillus fumigatus" isolées de patients et de leur proche environnement." Paris 5, 1997. http://www.theses.fr/1997PA05P098.

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29

Luther, Kathrin. "Interaktionen des humanpathogenen Schimmelpilzes Aspergillus fumigatus mit Wirtszellen." Diss., kostenfrei, 2007. http://edoc.ub.uni-muenchen.de/7678/.

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30

Amaar, Yousef Grera. "Molecular characterizations of nitrate assimilation in Aspergillus fumigatus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24287.pdf.

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31

Fraczek, Marcin Grzegorz. "The molecular analysis of allergens in Aspergillus fumigatus." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508896.

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32

Albarrag, Ahmed. "Azole resistance in clinical isolates of Aspergillus fumigatus." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487927.

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Aspergillus fil1nigatus is the most common aetiological agent of aspergillosis. Invasive aspergillosis is a major cause of death in leukaemic and organ transplant patients. The azoles are the largest and the most widely used class of antifungals. Antifungal drug resistance has been observed in many fungi. In many organisms, acquiring resistance to a drug can confer a biological fitness cost that is expressed for example as decreased growth rate or virulence. A total number of 21 A. fill11igatus clinical isolates were used in this project. Sixteen of these isolates were recovered serially from
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33

Mowat, Eilidh. "In vitro modelling of chronic Aspergillus fumigatus infections." Thesis, Glasgow Caledonian University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501309.

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Recent studies have demonstrated the potential of Aspergillus fumigatus to form biofilm structures similar to those identified with Candida albicans. In contrast to the wide berth of knowledge relating to the biology of C. albicans biofilms, relatively little is known regarding the development and morphology of multicellular communities of A. fumigatus. This alternate lifestyle may have profound clinical implications with regard to the pathogenic potential of the organism and the likelihood of successful detection and treatment. A reproducible biofilm model of A. fumigatus was developed using
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34

Júnior, André Oliveira Mota. "Caracterização molecular do gene ncsA de Aspergillus fumigatus." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-05012009-123104/.

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O foco do trabalho está direcionado para a construção da linhagem knock-out do gene ncsA de A. fumigatus, bem como a caracterização do fenótipo da linhagem DncsA e a investigação de interações deste gene com vias de sinalização importantes para o desenvolvimento do fungo. A linhagem mutante ncsA foi construída através da transformação do WT (Dku80) com o gene marcador pyrG de A. fumigatus. Foi confirmada a deleção por Southern blot e as alterações fenotípicas da linhagem foram analisadas. O gene ncsA em A. fumigatus não é essencial e a linhagem DncsA apresentou-se sensível EGTA e SDS, alé, de
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35

Jamal, Atif. "Incidence and characterisation of mycoviruses from Aspergillus fumigatus." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6092.

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This study investigated the incidence and characterisation of mycoviruses in a range of different fungi including Phytophthora spp. Phlebiopsis gigantea and Aspergillus fumigatus and their effects on their hosts. The investigation developed methodology for rapid molecular characterisation of dsRNA elements from different fungi which were applied in detail to a range of isolates of A. fumigatus. DsRNA elements or mycoviruses are present in almost all major classes of fungi where they lack an extracellular phase and are transmitted intracellulary via anastomosis or spores. Mycoviruses can confer
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36

Griffiths, James. "CLRs and their role during Aspergillus fumigatus infection." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/114588/.

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CLRs are vital for orchestrating anti-fungal immunity. These receptors are expressed on myeloid immune cells and induce robust anti-A.f. responses including phagocytosis, cytokine and chemokine release, respiratory burst, and inflammasome activation. The role of Dectin-1 has been thoroughly investigated; however, the CLRs requirement during anti-A.f. response is controversial. The impact of Dectin-2, Mcl and Mincle during anti-A.f. immunity is not well understood. A.f. is complex and poses many challenges for the immune system. PRR collaboration is likely required for A.f. clearance. Collabora
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37

Fillaux, Judith Sophie. "Évaluation de la sensibilisation à Aspergillus fumigatus et du portage persistant comme facteurs de détérioration de la fonction respiratoire des patients atteints de mucoviscidose au CHU de Toulouse." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2323/.

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Aspergillus fumigatus (Af) est responsable de maladies respiratoires. La mucoviscidose est une maladie génétique fréquente, à transmission autosomique récessive au cours de laquelle les manifestations respiratoires déterminent le pronostic de la maladie. Les publications sur les infections fongiques au cours de la mucoviscidose sont rares. Au CHU de Toulouse, deux CRCM, pédiatrique et adulte, suivent les patients de la région Midi-Pyrénées. Les médecins implémentent à chaque consultation un dossier informatisé. A partir de ces données, une étude a été menée afin de déterminer si le fait de pré
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38

Durand-Perdriel, François. "Aspergillose broncho-pulmonaire allergique (ABPA) (ou maladie de Hinson-Pepys) : à propos de six nouvelles observations dans l'Ouest." Nantes, 1985. http://www.theses.fr/1985NANT3351.

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39

Hamet, Nicole. "Contribution à la prophylaxie de l'aspergillose des volailles." Université Joseph Fourier (Grenoble), 1990. http://www.theses.fr/1990GRE18005.

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40

Cardoso, Fernanda Gomes. "Vias alternativas mitocondriais: estudos moleculares e bioquímicos de uma UCP-like de Aspergillus fumigatus." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/17/17131/tde-08012016-124834/.

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A. fumigatus é um patógeno oportunista que causa infecções invasivas em hospedeiros imunocomprometidos. Estudos de respiração mitocondrial sugeriram a presença de componentes alternativos em sua cadeia respiratória envolvidos com processos de adaptação a ambientes adversos, como a proteína desacopladora (UCP). UCPs são proteínas mitocondriais cuja atividade dissipa o potencial de membrana gerado durante o transporte de elétrons. Um gene contendo características das três assinaturas moleculares das Proteínas Transferidoras de Energia foi clonado e sequenciado. O alinhamento das sequências genôm
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41

Guazzelli, Luciana Silva. "Estudo etiológico, clínico, laboratorial e epidemiológico da bola fúngica pulmonar por Aspergillus spp." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/30929.

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Descrição: Bola fúngica é definida como uma macrocolônia composta por emaranhado de hifas, células inflamatórias, fibrina, muco e fragmentos de tecidos. Aspergillus fumigatus é o agente etiológico mais frequente, responsável por cerca de 90% dos casos, seguido de A niger e A flavus, respectivamente. O antecedente mais comum para o desenvolvimento da bola fúngica é cavidade secundária à tuberculose e a manifestação clínica mais presente e causadora de óbitos nesses pacientes é a hemoptise. Objetivos: Investigar as espécies de Aspergillus causadoras de bola fúngica pulmonar, determinar as condiç
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42

Fischer, Sandra Elena. "Vergleich von konventionellen PCR Methoden mit den Aspergillus fumigatus spezifischen Primern TS2 und AfLC2 und dem Panfungal-Primer für die Aspergillus fumigatus Diagnostik bei Risikopatienten." [S.l. : s.n.], 2007.

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43

Soriani, Frederico Marianetti. "Caracterização de uma cálcio ATPase PMR1 de \'Aspergillus fumigatus\'." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-02102008-163023/.

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Os conhecimentos sobre a regulação dos níveis de cálcio e manganês no Aspergillus fumigatus são bastante limitados, sendo que a homeostase destes íons pode ser diretamente controlada pela ação de ATPases específicas, dentre elas as cálcio ATPases da subfamília PMR1. Desta forma, o objetivo do presente estudo foi a expressão, caracterização e validação como alvo quimioterapêutico do gene Afpmr1 de A. fumigatus. Inicialmente, foi realizada a complementação funcional, de uma cepa de S. cerevisiae nocaute para a PMR1, em meios de cultura suplementados com EGTA ou manganês, revertendo o fenótipo da
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44

Vieira, Fabíola Giovanna Nesello. "Otimização da produção de β-xilosidase por Aspergillus fumigatus." Universidade Estadual do Oeste do Parana, 2014. http://tede.unioeste.br:8080/tede/handle/tede/187.

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Made available in DSpace on 2017-05-12T14:47:00Z (GMT). No. of bitstreams: 1 Fabiola G_ Nesello Vieira.pdf: 1352690 bytes, checksum: dde9077ce35994c9a408a58112929a03 (MD5) Previous issue date: 2014-06-10<br>The abundant lignocellulosic biomass in agro-industrial waste can be reused as an inexpensive substrate for inducing the production of enzymes such as &#946;-xylosidases. The purpose of this study was to analyze the production of &#946;-xylosidase from Aspergillus fumigatus (PC-7S-2 M), isolated from the Atlantic Forest of the Dog Head State Park (Paraná, Brazil) and later identified by m
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Vieira, Fabíola Giovanna Nesello. "Otimização da produção de β-xilosidase por Aspergillus fumigatus". Universidade Estadual do Oeste do Parana, 2014. http://tede.unioeste.br:8080/tede/handle/tede/2646.

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Made available in DSpace on 2017-07-10T19:23:47Z (GMT). No. of bitstreams: 1 Fabiola G_ Nesello Vieira.pdf: 1352690 bytes, checksum: dde9077ce35994c9a408a58112929a03 (MD5) Previous issue date: 2014-06-10<br>The abundant lignocellulosic biomass in agro-industrial waste can be reused as an inexpensive substrate for inducing the production of enzymes such as β-xylosidases. The purpose of this study was to analyze the production of β-xylosidase from Aspergillus fumigatus (PC-7S-2 M), isolated from the Atlantic Forest of the Dog Head State Park (Paraná, Brazil) and later identified by morpholog
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Morley, Joseph Peter. "Studies of clinical and environmental isolates of Aspergillus fumigatus." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/39567.

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Aspergillus fumigatus is a fungus of great environmental importance as well as being the most common filamentous fungal respiratory pathogen. Airborne A. fumigatus spores can reach potentially dangerous concentrations, particularly in the air around industrial composting sites. Drug resistant A. fumigatus infections are an increasingly common problem and the limited range of drugs available for the treatment of Aspergillus infections means that any resistance developing is a major cause for concern. Mycoviruses may offer an alternative approach to conventional treatment and exist in many funga
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Rowley, Jessica. "The interaction of Aspergillus fumigatus with the respiratory epithelium." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-interaction-of-aspergillus-fumigatus-with-the-respiratory-epithelium(0fc10449-977d-4f14-a169-172e8204fee4).html.

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Aspergillus fumigatus is a filamentous fungus and the main pathogen responsible for the often fatal respiratory condition, aspergillosis. Airway epithelial cells (AECs) are likely to be the first line of host defence that come into contact with the inhaled conidia of A. fumigatus. Recent evidence strongly suggests that the response of the airway epithelium to inhaled pathogens is pivotal in orchestrating immune responses by inducing phagocytic-like reactions and the secretion of inflammatory cytokines and antimicrobial peptides. However, the majority of previous work investigating A. fumigatus
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Safari, Maryam. "Aspergillosis : interactions of Aspergillus fumigatus and Human Airway Cells." Thesis, University of Westminster, 2013. https://westminsterresearch.westminster.ac.uk/item/8z158/aspergillosis-interactions-of-aspergillus-fumigatus-and-human-airway-cells.

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Aspergillus fumigatus is a filamentous fungus that colonises the lungs of immunosuppressed patients and causes aspergillosis. Despite recent medical advances, infectious diseases caused by opportunistic pathogens such as A. fumigatus are still one of the main causes of morbidity and mortality among immunosuppressed patients. Gliotoxin is a mycotoxin and a secondary metabolite of A. fumigatus. This toxin possesses immusuppresive activity affecting cells of immune system. This research shows that human adenocarcinoma alveolar epithelial cells (A549) are highly susceptible to gliotoxin- induced c
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Rodriguez, de Francisco Borja. "Self-assembly into functional amyloids of Aspergillus fumigatus hydrophobins." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS332.

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Les hydrophobines sont des protéines fongiques qui s’assemblent aux interfaces hydrophobes/hydrophiles ou air-eau (IHH) pour former des fibres amyloïdes fonctionnelles qui s’organisent en couches dont le caractère amphiphile détermine leurs fonctions. Les spores du champignon pathogène opportuniste Aspergillus fumigatus sont couvertes d’une couche de bâtonnets constitués de fibres amyloïdes formés par l’hydrophobine RodA. Ce revêtement hydrophobe facilite la dispersion des spores et les rend inertes vis à vis du système immunitaire humain. Deux proches homologues de RodA, RodB et RodC, sont au
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Hündling, Dörte. "Caractérisation biochimique et structurale de lectines d'Aspergillus fumigatus." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV055/document.

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L'objectif de cette thèse a été de contribuer à la compréhension des stratégies d'infection du pathogène opportuniste Aspergillus fumigatus. Ce pathogène est une cause émergente de morbidité et de mortalité chez les patients dont l'immunité est compromise et dans les milieux hospitaliers. Une infection avec Aspergillus est en général appelée une Aspergillose et ellepeut se développer dans un certain nombre d'organes, le plus fréquemment dansl'appareil respiratoire (poumons et sinus). Outre les infections (Aspergillosis invasive), la colonisation par ce champignon peut causer des réactions alle
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