Academic literature on the topic 'Aspergillus – Growth'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Aspergillus – Growth.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Aspergillus – Growth"

1

Rhodes, Judith C. "Aspergillus fumigatus: Growth and virulence." Medical Mycology 44, s1 (January 2006): 77–81. http://dx.doi.org/10.1080/13693780600779419.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Bhati, Praveesh. "EFFECT OF TEMPERATURES ON THE GROWTH OF FLORAL WASTE DEGRADING FUNGI." Fungal Territory 2, no. 2 (June 20, 2019): 12–15. http://dx.doi.org/10.36547/ft.2019.2.2.12-15.

Full text
Abstract:
The goal of present study was to find out optimum growth temperature of isolated floral waste degrading fungi viz. Aspergillus fumigatus, Aspergillus flavus, Alternaria alternate and Aspergillus terreus. Eleven different temperature range ( 20°C, 22°C, 24°C, 26°C, 28°C, 30°C, 32°C, 34°C,36°C,38°C,40°C) were selected to find the optimum growth of these fungi on floral extract-basal medium for flask experiments. The optimum growth temperature of all four fungal strains was found at 32°C±1°C. Beside Alternaria alternate, remaining other three selected fungal strains showed growth at all selected temperatures. At optimum growth temperature (32°C±1°C), the highest growth occurred in Aspergillus fumigates and Aspergillus terreus (155 mg/50 ml/7 days) while lowest growth was observed in Aspergillus flavus and Alternaria alternata (140 mg/50 ml/7 days). At minimum selected growth temperature (20°C), maximum growth was found in Aspergillus flavus (45 mg/50 ml/7 days) and lowest growth occurred in Alternaria alternata (35 mg/50 ml/7 days) while at maximum selected growth temperature (40°C) highest growth seen in Aspergillus fumigatus and Aspergillus flavus (30 mg/50 ml/7 days) and no growth recorded in Alternaria alternata (00 mg/50 ml/7 days).
APA, Harvard, Vancouver, ISO, and other styles
3

Singh, Daljit, Vikas Kumar, PoonamSood Loomba, and RavindraKumar Saran. "Aspergillus growth within ventriculoperitoneal shunt tube." Journal of Pediatric Neurosciences 12, no. 1 (2017): 83. http://dx.doi.org/10.4103/jpn.jpn_149_16.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Rachmawati, Laili, and Mustafidah Udkhiyati. "Toxicity Test of Chromium and Glutaraldehyde to Determine Greener Chemical in Tannery Industry." Materials Science Forum 901 (July 2017): 160–65. http://dx.doi.org/10.4028/www.scientific.net/msf.901.160.

Full text
Abstract:
The aim of this study was to investigate the toxicity level of chromium and glutaraldehyde. This research was conducted by testing the resistance level of fungi (Aspergillus niger sp.) toward glutaraldehyde and chromium in the medium of Potato Dextrose Agar (PDA). Variable of this experiment was the growth of Aspergillus niger sp. that indicates the resistance level of Aspergillus niger sp. The growth rate of Aspergillus niger sp. was classified on four scales. They were, (I) scale 1: zero growth; (II) scale 2: low growth (+); (III) scale 3: medium growth (++); (IV) Scale: 4 high growth (+++). All collected data were analysed by One Way ANOVA. The result showed that the toxicity of chromium and glutaraldehyde tanning material were highly significantly different toward Aspergillus niger (P<0,01). The Aspergillus niger sp. growth rate scale in chromium medium was high (scale 4: 4.00±0.00). Meanwhile, the growth rate scale of the Aspergillus niger sp. in glutaraldehyde medium was low (scale 2: 1.33 ± 0.58). Based on the fungi growth rate, it can be concluded that glutaraldehyde was more toxic than chromium tanning material toward Aspergillus niger sp. Furthermore, it can be said that glutaraldehyde is not quite ideal to be used as an alternative of chromium as a tanning material.
APA, Harvard, Vancouver, ISO, and other styles
5

CAMPANIELLO, DANIELA, MARIA ROSARIA CORBO, and MILENA SINIGAGLIA. "Antifungal Activity of Eugenol against Penicillium, Aspergillus, and Fusarium Species." Journal of Food Protection 73, no. 6 (June 1, 2010): 1124–28. http://dx.doi.org/10.4315/0362-028x-73.6.1124.

Full text
Abstract:
The antifungal activity of eugenol in a model system against aspergilli (Aspergillus niger, Aspergillus terreus, and Emericella nidulans), penicilli (Penicillium expansum, Penicillium glabrum, and Penicillium italicum), and fusaria (Fusarium oxysporum and Fusarium avenaceum) was investigated. Minimum detection time (time to attain a colony diameter of 1 cm) and the kinetic parameters were evaluated. The effectiveness of the active compound seemed to be strain or genus dependent; 100 mg/liter represented a critical value for P. expansum, P. glabrum, P. italicum, A. niger, and E. nidulans because a further increase of eugenol resulted in fungistatic activity. The radial growth of A. terreus and F. avenaceum was inhibited at 140 mg/liter, and growth of F. oxysporum was completely inhibited at 150 mg/liter.
APA, Harvard, Vancouver, ISO, and other styles
6

Mindubaev, Anton Z., Elena K. Badeeva, Salima T. Minzanova, Lubov G. Mironova, Edward V. Babynin, and Yaw Abaye Akosah. "The influence of the culture media composition on the white phosphorus biodegradation by Aspergillus niger." Butlerov Communications 58, no. 5 (May 31, 2019): 1–23. http://dx.doi.org/10.37952/roi-jbc-01/19-58-5-1.

Full text
Abstract:
The biodegradation of white phosphorus is undoubtedly an amazing illustration of the adaptability of living organisms to adverse environmental factors. In addition, it is a potential basis for the creation of new, breakthrough methods for detoxifying substances of the first class danger. However, establishing the fact of biological destruction is only half the battle. It is essential to optimize the growth conditions of microbial cultures and P4 biodegradation for industrial cultivation. The presented study compared the growth of Aspergillus niger strain AM1 in culture media varying in composition but containing P4 as the sole source of phosphorus. Of the ten media, two in which Aspergillus grew the fastest were selected. These media were concluded to be optimal for growth. Comparing the compositions of the media and the growth rate of Aspergillus in them, we found a key component that is a favorable factor for the growth of AM1 and the biodegradation of white phosphorus. This component was sodium nitrate (NaNO3). It has also been shown that copper sulphate (CuSO4) has no effect on the growth of Aspergillus in media with white phosphorus, regardless of the composition of these media. This result is in harmony with our previous findings. Furthermore, in the present work, attempts to increase the concentration of white phosphorus in the culture medium to values above 1% are described for the first time. For this purpose, we added the following solvents to the culture media: dimethyl sulfoxide (DMSO) and diesel, in which white phosphorus dissolves relatively well. Apparently, the presence of these substances adversely affects the growth of Aspergill. Therefore, the problem of further increasing the concentration of P4 remains an unanswered.
APA, Harvard, Vancouver, ISO, and other styles
7

Taheri-Talesh, Naimeh, Tetsuya Horio, Lidia Araujo-Bazán, Xiaowei Dou, Eduardo A. Espeso, Miguel A. Peñalva, Stephen A. Osmani, and Berl R. Oakley. "The Tip Growth Apparatus of Aspergillus nidulans." Molecular Biology of the Cell 19, no. 4 (April 2008): 1439–49. http://dx.doi.org/10.1091/mbc.e07-05-0464.

Full text
Abstract:
Hyphal tip growth in fungi is important because of the economic and medical importance of fungi, and because it may be a useful model for polarized growth in other organisms. We have investigated the central questions of the roles of cytoskeletal elements and of the precise sites of exocytosis and endocytosis at the growing hyphal tip by using the model fungus Aspergillus nidulans. Time-lapse imaging of fluorescent fusion proteins reveals a remarkably dynamic, but highly structured, tip growth apparatus. Live imaging of SYNA, a synaptobrevin homologue, and SECC, an exocyst component, reveals that vesicles accumulate in the Spitzenkörper (apical body) and fuse with the plasma membrane at the extreme apex of the hypha. SYNA is recycled from the plasma membrane by endocytosis at a collar of endocytic patches, 1–2 μm behind the apex of the hypha, that moves forward as the tip grows. Exocytosis and endocytosis are thus spatially coupled. Inhibitor studies, in combination with observations of fluorescent fusion proteins, reveal that actin functions in exocytosis and endocytosis at the tip and in holding the tip growth apparatus together. Microtubules are important for delivering vesicles to the tip area and for holding the tip growth apparatus in position.
APA, Harvard, Vancouver, ISO, and other styles
8

Sohrabi, Nooshin, Zuhair Muhammad Hassan, Ali Reza Khosravi, Majid Tebianian, Mehdi Mahdavi, Zahra Tootian, Seyyed Mahmoud Ebrahimi, Mohammad Hosein Yadegari, and Zahra Gheflati. "Invasive aspergillosis promotes tumor growth and severity in a tumor-bearing mouse model." Canadian Journal of Microbiology 56, no. 9 (September 2010): 771–76. http://dx.doi.org/10.1139/w10-064.

Full text
Abstract:
Invasive aspergillosis increases in chronic immunosuppressive diseases such as cancer. There is little information about the mechanisms by which Aspergillus infection affects the immune regulation and microenvironment of cancer cells. Hence, this study was aimed at investigating the effect of invasive aspergillosis on immunosurveillance, metastasis, and prognosis of cancer in tumor-bearing mice. After implantation of mouse mammary tumor in BALB/c mice, they were infected with Aspergillus conidia intravenously. For comparison, groups of mice were experimentally infected with Aspergillus conidia or implanted with tumor cells separately. Seven days after Aspergillus infection, the serum levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) were measured by ELISA, and subsequently regulatory T lymphocytes were analyzed by flow cytometry. The survival of animals and mean tumor size were then determined. Our results indicated that tumor sizes in mice increased significantly after infection with Aspergillus conidia. Moreover, invasive aspergillosis enhanced the population of regulatory lymphocytes and level of TIMP-1. This study supports the idea that massive Aspergillus infection could stimulate tumor growth and increases the possibility of a bad prognosis. As a result, treatment of Aspergillus infection could be considered an important issue for efficient cancer therapy.
APA, Harvard, Vancouver, ISO, and other styles
9

Wilson, Richard A., Ana M. Calvo, Perng-Kuang Chang, and Nancy P. Keller. "Characterization of the Aspergillus parasiticus Δ12-desaturase gene: a role for lipid metabolism in the Aspergillus–seed interaction." Microbiology 150, no. 9 (September 1, 2004): 2881–88. http://dx.doi.org/10.1099/mic.0.27207-0.

Full text
Abstract:
In the mycotoxigenic oilseed pathogens Aspergillus flavus and Aspergillus parasiticus and the model filamentous fungus Aspergillus nidulans, unsaturated fatty acids and their derivatives act as important developmental signals that affect asexual conidiospore, sexual ascospore and/or sclerotial development. To dissect the relationship between lipid metabolism and fungal development, an A. parasiticus Δ12-desaturase mutant that was unable to convert oleic acid to linoleic acid and was thus impaired in polyunsaturated fatty acid biosynthesis was generated. The Δ12-desaturase mutant demonstrates delayed spore germination, a twofold reduction in growth, a reduced level of conidiation and complete loss of sclerotial development, compared to the wild-type. Host colonization is impaired, as reflected by a decrease in conidial production on live peanut and corn seed by the mutant compared to the wild-type. Similarly, the previously isolated A. nidulans Δ12-desaturase mutant has reduced colonization capabilities compared to the wild-type. Therefore, desaturation mutants display a key requisite that affords a genetic solution to oilseed crop contamination by mycotoxigenic Aspergillus species: a reduction in the production of conidia, the infectious particle of the pathogenic aspergilli.
APA, Harvard, Vancouver, ISO, and other styles
10

Priesterjahn, Eva-Maria, Rolf Geisen, and Markus Schmidt-Heydt. "Influence of Light and Water Activity on Growth and Mycotoxin Formation of Selected Isolates of Aspergillus flavus and Aspergillus parasiticus." Microorganisms 8, no. 12 (December 15, 2020): 2000. http://dx.doi.org/10.3390/microorganisms8122000.

Full text
Abstract:
Aspergillus flavus and A. parasiticus are the main causes of aflatoxin contamination in various foods, particularly grains, as they can thrive in environments with lower water activity and higher temperatures. The growth of Aspergillus and the formation of the mycotoxins aflatoxin and cyclopiazonic acid are strongly influenced by environmental stimuli and can be reduced by modulating parameters such as water activity, pH, temperature and light during the storage. This study has two objectives—on the one hand, to assess how global warming and an increase in exposure to sunlight affect growth and mycotoxin formation, and on the other hand, how the findings from these experiments can be used to reduce fungal growth and mycotoxin formation in stored foods. Using growth substrates with two different water activities (aw 0.95, aw 0.98), together with a light incubation device consisting of different chambers equipped with diodes emitting visible light of five different wavelengths (455 nm, 470 nm, 530 nm, 590 nm, 627 nm) plus white light, we analyzed the growth and mycotoxin formation of selected Aspergillus flavus and A. parasiticus isolates. It was shown that light with a wavelength of 455/470 nm alone, but especially in combination with a lower water activity of aw 0.95, leads to a significant reduction in growth and mycotoxin formation, which was accompanied by reduced transcriptional activity of the responsible mycotoxin biosynthetic genes. Therefore, these results can be used to significantly reduce the growth and the mycotoxin formation of the analyzed fungi during storage and to estimate the trend of fungal infestation by Aspergillus flavus and A. parasiticus in water activity- and light exposure-equivalent climate change scenarios. Mycotoxin-producing aspergilli can be effective and sustainably inhibited using a combination of short-wave light and lowered water activity in the substrate. A higher annual mean temperature accompanying climate change may lead to an increased spread of aflatoxin-producing fungi in areas that were previously too cold for them. On the other hand, there will be regions in the world where contamination with aflatoxin-producing fungi will be reduced due to increased drought and sun exposure.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Aspergillus – Growth"

1

Moore, Jocelyn. "Control of Aspergillus Flavus Infection and Growth." Thesis, University of Louisiana at Lafayette, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10247200.

Full text
Abstract:

Aspergillus flavus infection of agriculturally important crops such as tree nuts, maize, peanuts, and cotton has decreased crop value. Researchers have identified three major approaches to combat A. flavus growth and aflatoxin accumulation: identifying natural resistance in crops, genetically engineering crops for enhanced resistance, and introducing an atoxigenic fungal strain as a competitor. In this dissertation, I investigated two of the three means to control A. flavus growth and infection: genetically engineered crops and identification of natural resistance. My studies of natural resistance in cotton crop show that Sa 1595, a Gossypium hirsutum cultivar, is significantly more susceptible to A. flavus infection; however, no significantly resistant cultivars were observed, but I did observe a trend of diminished susceptibility in A2 186 and Tamcot Sp 23. I then examined synthetic antimicrobial peptide, D4E1, as a means to increase resistance in crops. My research shows that D4E1 effectively increases reactive oxygen species (ROS), an apoptosis precursor at concentrations as low as 1 µM. Breaches in the membrane that allow infiltration and subsequent fluorescence from Sytox® green occur at higher concentrations. Finally, genetically engineered tobacco plants were examined for D4E1 localization. My research shows that the HA-D4E1 construct was present in the most abundance in the chloroplast of plastid transformed plants, while nuclear transformed plants had nuclear localization. All of my findings suggest that cotton crops do not exhibit any significant enhanced natural resistance to A. flavus infection and growth; however, engineering crops with D4E1 will exhibit enhanced crop resistance.

APA, Harvard, Vancouver, ISO, and other styles
2

Hughes, Glenda May. "Lipid accumulation and utilization during microcycle growth of Aspergillus niger." Thesis, Sheffield Hallam University, 1986. http://shura.shu.ac.uk/19842/.

Full text
Abstract:
Aspergillus niger was grown in fermenter culture under conditions promoting microcycle growth. Following a period of spherical growth at elevated temperatures for 24h, conidiophores developed from the swollen giant cells when the temperature was decreased. Each stage in this microcycle conidiation was photographed and dry weight was determined. Aberrant growth forms sometimes occurred and these are described with the measures taken to attempt to minimize such problems. The lipid content and composition was investigated throughout the microcycle by the use of column and thin layer chromatography and by gas-liquid chromatography. The major classes of neutral lipid were triacyl glycerols, fatty acids, sterols and sterol esters. Changes in composition during the microcycle are discussed in relation to metabolic requirements for the different developmental stages and a function for triacyl glycerol as an energy reserve for conidiation is suggested. The fatty acid composition was also determined throughout the cycle and changes related to growth temperature. The accumulation and utilization of triacyl glycerol was indicative of changes in activity of lipolytic enzymes. However little lipase activity was detected, although enzymes which hydrolysed water-soluble esters were more readily assayed. In order to assess the relative utilization of each of the carbon substrates glucose, L-glutamate and L-alanine, they were provided in a radiolabelled form and the fate of the label followed at intervals throughout the cycle. The majority of the material was used in the production of insoluble cellular material, with smaller amounts incorporated into lipids, water-soluble materials or released as carbon dioxide. Very little label from L-glutamate was detected as lipid. Glutamate was principally used during the later, conidiation, stage of the microcycle. The results are discussed in relation to the different physiological stages of microcycle conidiation and to the observed changes in lipid content and composition.
APA, Harvard, Vancouver, ISO, and other styles
3

Fortwendel, Jarrod R. "Aspergillus Fumigatus Ras Homologs Regulate Vegetative Growth, Development and Virulence." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1128432277.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Hassan, Saad A. "Influence of Cholesterol Import on Aspergillus fumigatus Growth and Antifungal Suscepibility." Thesis, University of North Texas, 2003. https://digital.library.unt.edu/ark:/67531/metadc5539/.

Full text
Abstract:
Invasive pulmonary aspergillosis is a life-threatening fungal infection commonly observed in immunocompromised patients and has a mortality rate approaching 100% once the disease is disseminated. Aspergillus fumigatus is the most common pathogen. Early diagnosis improves the prognosis but is very difficult since most signs and symptoms are nonspecific. Antifungal therapy, usually based on sterol biosynthesis inhibitors, is also of limited efficacy. In my attempts to discover a diagnostic sterol marker for aspergillosis, I observed that A. fumigatus incorporates large amounts of cholesterol from serum-containing medium. This observation suggested the hypothesis that exogenous cholesterol from the host can be imported by A. fumigatus and used as a substitute for ergosterol in the cell membrane. This proposed mechanism would reduce the efficacy of antifungal drugs that act as sterol biosynthesis inhibitors. Experiments to test this hypothesis were designed to determine the effects of serum-free and serum-containing medium on growth of A. fumigatus in the presence and absence of azole antifungal agents. The results showed a marked increase in growth in the presence of human serum. Cultures in media containing cholesterol but no serum also showed enhanced growth, a result indicating that a non-cholesterol component of serum is not primarily responsible for the increased growth. However, sterol analysis of A. fumigatus cultured in the absence of inhibitors showed little or no change in ergosterol levels. This result suggested that the imported cholesterol was not being used as membrane sterol. However, in parallel experiments using Itraconazole™, an antifungal agent that attenuates sterol biosynthesis by inhibiting the sterol 14a-demethylase (ERG11), ergosterol levels decreased with increasing doses of inhibitor. Moreover, serum-containing medium partially rescued A. fumigatus from the effects of Itraconazole™, and a similar rescue effect was observed with serum-free media containing cholesterol. From the preceding results, it can be concluded that human serum enhances A. fumigatus growth, that cholesterol import rescues Aspergillus from the effects of antifungal agents, that the potency of some azole antifungals is decreased by cholesterol, and that imported cholesterol may substitute for membrane ergosterol in the presence of sterol biosynthesis inhibitors.
APA, Harvard, Vancouver, ISO, and other styles
5

Safaie, Mehran. "Genetic control of hyphal cell growth and polarity in Aspergillus nidulans." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341792.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Ellis, William Otoo. "Effect of modified atmosphere packaging on the growth and aflatoxin production by Aspergillus flavus and Aspergillus parasiticus under tropical environmental storage conditions." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41118.

Full text
Abstract:
The combined effect of Modified Atmosphere Packaging (MAP) involving gas packaging, oxygen absorbent and other environmental factors to control aflatoxin production by Aspergillus flavus and Aspergillus parasiticus in both synthetic media and peanuts were studied using a process optimization technique termed Response Surface Methodology (RSM). Regression analysis of the data indicated that water activity (a$ sb{ rm w}$), pH, storage temperature, initial concentration of headspace oxygen and inoculum level were all highly significant factors (p 0%). These changes in the barrier characteristics influenced the headspace gas composition within the product and under modified atmospheres hence the level of aflatoxin detected in these stored products.
In conclusion, this study has shown that the combined effect of several "barriers" can be used in conjunction with low oxygen modified atmosphere and high barrier packaging films to inhibit or reduce aflatoxin to safe and acceptable levels, particularly at abusive temperatures encountered during storage.
APA, Harvard, Vancouver, ISO, and other styles
7

Lee, Soo Chan. "The roles of N-myristoylation in cell morphogenesis in Aspergillus nidulans." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2583.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Belewa, Xoliswa Vuyokazi. "The effect of tulbaghia violacea plant extract on the growth of aspergillus species." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/d1008186.

Full text
Abstract:
Traditional medicine has become an important part of healthcare worldwide. It is estimated that about 25 percent of prescribed medicines contain plant products or active compounds derived from plants. In South Africa, traditional medicine forms part of the culture and tradition of most communities. Garlic compounds have been shown to have a variety of antimicrobial properties. Amongst these are antifungal, antibacterial, antiviral and anti protozoal activities. Allicin and its breakdown products have been shown to be the main active compounds which possess these properties. Tulbaghia violacea has been used for the treatment of a variety of illnesses including asthma, fever, oesophageal cancer, constipation and hypertension. This study investigated the antifungal nature of T.violacea on the morphology, spore germination and lipid synthesis of Aspergillus flavus and Aspergillus parasiticus. The results of this study showed that the plant extract inhibited A. flavus growth at a minimal inhibitory concentration of 15mg/ml and was fungicidal at 20mg/ml and above. A. parasiticus was not inhibited at 25mg/ml indicating resistance to the inhibitory component of the plant extract. A measure of metabolic activity using the XTT assay showed reduced metabolic activity in the presence of increasing concentrations of the plant extract. Higher extract concentrations resulted in higher percentage inhibition of fungal growth for both fungal species with up to 98 percent inhibition being observed for the highest extract concentrations for both fungi. Germination was also delayed in the presence of 15mg/ml plant extract concentration by up to 60hr for A. flavus and 48hr for A. parasititcus. The TEM results showed increased thickening of the cell wall with higher extract concentrations. The thickening was greater for A. flavus than for A. parasiticus. Cell wall thickening may be the reason for the delay in germination in both species. Lipid production was reduced in the presence of plant extracts when compared to the control. The plant extracts inhibited triglyceride production at 15mg/ml for both A. flavus and A. parasiticus. The results therefore indicate that T. violacea extracts are antifungal and probably affect germination through interactions with the cell wall. It is possible that the extract affects lipid production in Aspergillus species.
APA, Harvard, Vancouver, ISO, and other styles
9

Moreno, Velásquez Sergio. "The cellular and molecular responses of Aspergillus fumigatus to the antifungal drug caspofungin." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/the-cellular-and-molecular-responses-of-aspergillus-fumigatus-to-the-antifungal-drug-caspofungin(cf4638e8-6f50-455d-b9b3-2a27fab6da9b).html.

Full text
Abstract:
The opportunistic fungus Aspergillus fumigatus has emerged as one of the most common fungal human pathogens, causing severe and usually fatal systemic infections that account for more than 200,000 cases annually with mortality rates usually exceeding 50%. During infection, the virulence of A. fumigatus highly depends on its capacity to rapidly respond to external stress encounters in the human niche, such as the host immunological response and the activity of antifungal drugs. The echinocandin, caspofungin, is one of most commonly used antifungal drugs to treat intolerant or refractive patients suffering from invasive aspergillosis. Caspofungin disrupts the catalytic subunit of the β-1,3-glucan synthase complex, Fks1, resulting in the reduced production of the main cell wall component of A. fumigatus, the polysaccharide β-1,3-glucan. Despite its clinical relevance in patients with aspergillosis, caspofungin displays attenuated activity at high concentrations, a phenomenon known as ‘the paradoxical effect’. Little is known about the paradoxical growth of A. fumigatus during caspofungin treatment. Therefore, in this thesis, I investigated the key cellular and molecular responses of A. fumigatus upon caspofungin treatment, particularly during paradoxical growth by live-cell imaging. High-resolution confocal live-cell microscopy revealed that treatment with either low (0.5 µg/ml) or high (4 µg/ml) concentrations of caspofungin for 36 h caused similar abnormalities in A. fumigatus, including wider, hyperbranched hyphae, increased septation and repeated hyphal tip lysis. Regenerative intrahyphal growth occurred as a rapid adaptation to the lytic effects of caspofungin on hyphal tips and the dynamic relocation of Fks1 to vacuoles was a key feature observed in response to caspofungin treatment. The reduced amount of β-1,3-glucan resulting from caspofungin treatment was compensated by increased α-1,3-glucan and chitin content in mature hyphal tips. Interestingly, all lysed cells recovered by regenerative intrahyphal growth. However, after 48 h treatment, only cells exposed to high caspofungin concentrations developed paradoxical growth in leading hyphae. This response was associated with a relocalization of Fks1 at hyphal tips. Consistently, cells undergoing paradoxical growth showed normal morphology and ceased to undergo cell lysis, as well as having a normal content of β-1,3-glucan and α-1,3-glucan but not chitin, which remained high. Notably, the localization of the regulatory subunit of the β-1,3-glucan synthase complex, Rho1, was unaffected by caspofungin, but it was required for the development of paradoxical growth. Interestingly, the gene expression of the β-1,3-glucan synthase complex was downregulated by caspofungin treatment. In addition, caspofungin activity induced the nuclear translocation of the Ca+2 regulated transcription factor CrzA to nuclei and only hyphal tip cells in which this translocation occurred underwent cell lysis. Finally, similarly high concentrations of caspofungin also induced paradoxical growth of Aspergillus fumigatus during human A549 alveolar cell invasion. This thesis outlines several critical adaptations that occur at the cellular, subcellular and molecular levels at different times during exposure to high and low concentration of caspofungin.
APA, Harvard, Vancouver, ISO, and other styles
10

Mitchell, D. "Ecological factors affecting growth and ochratoxim A production of Aspergillus section Nigri species on grapes." Thesis, Cranfield University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431810.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Aspergillus – Growth"

1

Lee, Philip. Evaluation of the effect of osmotic and temperature stress on growth rates of Aspergillus nidulans and Dendryphiella salina strains, and an assessment of their spore's survival in various microcosms. Wolverhampton: University of Wolverhampton, 1995.

Find full text
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Aspergillus – Growth"

1

Momany, Michelle, and Yainitza Hernández-Rodríguez. "Growth Polarity." In Aspergillus fumigatus and Aspergillosis, 143–48. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555815523.ch11.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Palou, Enrique, and Aurelio López-Malo. "Probabilistic modelling of Aspergillus growth." In Advances in Experimental Medicine and Biology, 287–306. Boston, MA: Springer US, 2006. http://dx.doi.org/10.1007/0-387-28391-9_19.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

van Verseveld, Henk W., M. Metwally, M. el Sayed, M. Osman, Jaap M. Schrickx, and Adriaan H. Stouthamer. "Determination of the maximum product yield from glucoamylase-producing Aspergillus niger grown in the recycling fermentor." In Quantitative Aspects of Growth and Metabolism of Microorganisms, 313–23. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2446-1_13.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Bensoussan, M., G. Alcaraz, and V. Tourtel. "Growth characteristics of Aspergillus chevalieri and other fungi from under-coating of chocolate truffles." In Advances in Solid State Fermentation, 39–47. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-017-0661-2_4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Carlsen, M., A. Spohr, R. Mørkeberg, J. Nielsen, and J. Villadsen. "Growth and Protein Formation of Recombinant Aspergillus: Utility of Morphological Characterization by Image Analysis." In Advances in Bioprocess Engineering, 197–202. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-017-0641-4_27.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Favela-Torres, E., M. García-Rivero, J. Cordova-López, S. Roussos, G. Viniegra-González, M. Gutiérrez-Rojas, G. Saucedo-Castañeda, P. Gunasekaran, and S. Huerta-Ochoa. "Kinetics of Aspergillus niger growth at high glucose concentrations in different types of the cultures." In Advances in Solid State Fermentation, 49–58. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-017-0661-2_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Dutra, Julio C. V., Selma C. da Terzi, Juliana Vaz Bevilaqua, Mônica C. T. Damaso, Sônia Couri, Marta A. P. Langone, and Lilian F. Senna. "Lipase Production in Solid-State Fermentation Monitoring Biomass Growth of Aspergillus niger Using Digital Image Processing." In Biotechnology for Fuels and Chemicals, 431–43. Totowa, NJ: Humana Press, 2007. http://dx.doi.org/10.1007/978-1-60327-526-2_41.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Smith, Thomas M., Daryl L. Richie, and Jianshi Tao. "A Fluorescence-Based High-Throughput Screening Assay to Identify Growth Inhibitors of the Pathogenic Fungus Aspergillus fumigatus." In Methods in Molecular Biology, 171–79. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3673-1_11.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Lambraki, M., S. Marakis, L. Hannibal, and S. Roussos. "Effects of sugar and mineral salts on the growth of Aspergillus carbonarius in carob pod solid state fermentation." In Advances in Solid State Fermentation, 245–55. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-017-0661-2_20.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Nanasombat, S., N. Piumnoppakun, D. Atikanbodee, and M. Rattanasuwan. "Combined Effect of Cinnamon Essential Oil and Water Activity on Growth Inhibition of Rhizopus stolonifer and Aspergillus fl avus and Possible Application in Extending the Shelf Life of Bread." In Water Properties in Food, Health, Pharmaceutical and Biological Systems: ISOPOW 10, 545–50. Oxford, UK: Wiley-Blackwell, 2010. http://dx.doi.org/10.1002/9780470958193.ch48.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Aspergillus – Growth"

1

Matsuura, Shu, and Sasuke Miyazima. "Growth pattern of the surface of fungus Aspergillus colony." In Slow dynamics in condensed matter. AIP, 1992. http://dx.doi.org/10.1063/1.42413.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Hughes, DA, L. Cuthbertson, H. Price, I. Felton, M. Coates, NJ Simmonds, MR Loebinger, et al. "P130 Pseudomonas aeruginosa impairs growth of aspergillus from CF airway samples." In British Thoracic Society Winter Meeting, Wednesday 17 to Friday 19 February 2021, Programme and Abstracts. BMJ Publishing Group Ltd and British Thoracic Society, 2021. http://dx.doi.org/10.1136/thorax-2020-btsabstracts.275.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Mateo, Eva M., A. Medina, F. M. Valle-Algarra, F. Mateo, M. A. García Esparza, and M. Jiménez. "Efficacy of three antifungal chemicals on the growth in vitro of Aspergillus ochraceus and Aspergillus carbonarius strains isolated from Spanish barley." In Proceedings of the III International Conference on Environmental, Industrial and Applied Microbiology (BioMicroWorld2009). WORLD SCIENTIFIC, 2010. http://dx.doi.org/10.1142/9789814322119_0082.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Veras, Flávio Fonseca, Roberta Fontoura, Ana Paula Folmer Correa, Tiago Centeno Einloft, Adriano Brandelli, and Juliane Elisa Welke. "Inhibition of Growth of Aspergillus Flavus and Aflatoxin Production by Pseumononas Sp. Strain 4B." In XII Latin American Congress on Food Microbiology and Hygiene. São Paulo: Editora Edgard Blücher, 2014. http://dx.doi.org/10.5151/foodsci-microal-093.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Mindubaev, A. Z., E. V. Babynin, E. K. Badeeva, and Y. A. Akosah. "Strain Aspergillus niger AM1 – a living organism resistant to white phosphorus." In 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.172.

Full text
Abstract:
Copper sulphate has no effect on the growth of aspergill in a media with white phosphorus. We compared the white phosphorus resistance of A. niger AM1 with three strains from the All-Russian Collection of Microorganisms. Highest resistance was observed in AM1.
APA, Harvard, Vancouver, ISO, and other styles
6

Qian-Wei, Li, Yan Pei-Sheng, Wu Han-Qi, and Wang Kai. "Inhibition of mycelia growth and norsolorinic acid accumulation of Aspergillus parasiticus by peanut seed endophytic bacteria." In 2011 International Conference on Human Health and Biomedical Engineering (HHBE). IEEE, 2011. http://dx.doi.org/10.1109/hhbe.2011.6027996.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

C, AGBALA C., ITELIMA J U, NWADIARO P O, NYAM M A, OGBONNA A I, and ONYIMBA I A. "Growth and yield response of cowpea Vigna unguiculata to bio fertilizers produced from Aspergillus niger and animal waste materials." In Third International Conference on Advances in Bio-Informatics, Bio-Technology and Environmental Engineering- ABBE 2015. Institute of Research Engineers and Doctors, 2015. http://dx.doi.org/10.15224/978-1-63248-060-6-51.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Chu, Xuan, Wei Wang, Xin Zhao, Haitao Zheng, Daniel Kimuli, Hongzhe Jiang, Beibei Jia, and Yi Yang. "<i>Evaluation of growth characteristics of Aspergillus parasiticus by shortwave infrared (SWIR) hyperspectral imaging</i>." In 2017 Spokane, Washington July 16 - July 19, 2017. St. Joseph, MI: American Society of Agricultural and Biological Engineers, 2017. http://dx.doi.org/10.13031/aim.201700762.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Wiradana, Putu Angga, Ida Bagus Gede Darmayasa, and Ngurah Intan Wiratmin. "The Test of Saccharomyces sp. Potential Filtrate to Inhibit The Growth of Aspergillus flavus FNCC6109 Broiler Chicken Concentrate Feed Model." In 2nd International Conference Postgraduate School. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0007546405320536.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

García-Esparza, M. A., Eva M. Mateo, F. M. Valle-Algarra, R. Mateo-Castro, and M. Jiménez. "Effect of carbendazim and water activity on the growth of Aspergillus ochraceus and ochratoxin A accumulation in solid medium containing bee pollen." In Proceedings of the III International Conference on Environmental, Industrial and Applied Microbiology (BioMicroWorld2009). WORLD SCIENTIFIC, 2010. http://dx.doi.org/10.1142/9789814322119_0081.

Full text
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography