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Journal articles on the topic 'Asphyxia, therapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Gathwala, Geeta, Atul Khera, and Ishwar Singh. "Magnesium therapy in birth asphyxia." Indian Journal of Pediatrics 73, no. 3 (2006): 209–12. http://dx.doi.org/10.1007/bf02825482.

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2

Dang, Xiaoping, Xiaojian Hu, Yuancui Meng, et al. "The Diagnostic Value of Cystatin C and Mild Hypothermia Therapy Based on Immunoturbidimetry Enhanced by Nanospheres in Asphyxia Neonate." Journal of Chemistry 2020 (December 10, 2020): 1–10. http://dx.doi.org/10.1155/2020/1549795.

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In order to evaluate the early diagnosis value of CysC and the influence of mild hypothermia on the renal damage of asphyxia neonates, the serum cystatin C (CysC) levels of asphyxia neonates and normal neonates were measured by the nanomicrosphere-enhanced immunoturbidimetric method. The treatment was carried out, and the influence of mild hypothermia treatment on the renal damage of asphyxia neonates was analyzed. The results showed that the indicators of the asphyxia group were significantly higher than those of the control group, and the severe asphyxia group was significantly higher than t

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Ais Izza Fadhilah, Falasifah Ani Yuniarti, and Rina Prawati. "Pengaruh Terapi Murotal Al-Quran Surah Ar Rahman Terhadap Kestabilan Saturasi Oksigen BBLR Dengan Asfiksia di Ruang NICU." Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan 2, no. 2 (2024): 97–106. http://dx.doi.org/10.61132/corona.v2i2.404.

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Background: LBW babies face difficulties adapting to life outside the womb because their organs, such as the lungs, heart, kidneys, liver and digestive system, are not fully mature. The neonatal period is the most vulnerable period for a baby's survival, and one of the causes of newborn deaths is asphyxia. One of the complementary therapy techniques that can be used to increase saturation and hemodynamics in LBW babies is music therapy and murrotal therapy. Research method: The research method used in the intervention is a case report using the intervention method. The research was carried out

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Lear, Christopher A., Joanne O. Davidson, Georgia R. Mackay, et al. "Antenatal dexamethasone before asphyxia promotes cystic neural injury in preterm fetal sheep by inducing hyperglycemia." Journal of Cerebral Blood Flow & Metabolism 38, no. 4 (2017): 706–18. http://dx.doi.org/10.1177/0271678x17703124.

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Antenatal glucocorticoid therapy significantly improves the short-term systemic outcomes of prematurely born infants, but there is limited information available on their impact on neurodevelopmental outcomes in at-risk preterm babies exposed to perinatal asphyxia. Preterm fetal sheep (0.7 of gestation) were exposed to a maternal injection of 12 mg dexamethasone or saline followed 4 h later by asphyxia induced by 25 min of complete umbilical cord occlusion. In a subsequent study, fetuses received titrated glucose infusions followed 4 h later by asphyxia to examine the hypothesis that hyperglyce

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Loboda, A. M., O. I. Smiyan, S. V. Popov, V. O. Petrashenko, and D. A. Loboda. "PECULIARITIES OF ELECTROLYTIC BALANCE IN THE BLOOD OF NEWBORNS WITH KIDNEY DAMAGE DUE TO ASPHYXIA." Eastern Ukrainian Medical Journal 7, no. 4 (2019): 341–50. http://dx.doi.org/10.21272/eumj.2019;7(4):341-350.

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Introduction. The study of the concentration of main electrolytes in serum of blood and erythrocytes in neonates with impaired renal function due to asphyxia is important, because it allows determining violations of their content and balance, tactics of infusion and diuretic therapy. The purpose of the work is explore the features of the content and balance of electrolytes (sodium, potassium, calcium, magnesium) in serum and red blood cells of newborns with disturbance kidney function due to asphyxia. Materials and methods. The study involved 200 term infants with signs of disturbance kidney f

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6

Ford, Lisa M. "Results of antagonists in perinatal cerebral asphyxia therapy." Pediatric Neurology 6, no. 6 (1990): 363–66. http://dx.doi.org/10.1016/0887-8994(90)90001-h.

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Tarkowska, Agata, Wanda Furmaga-Jabłońska, Jacek Bogucki, Janusz Kocki, and Ryszard Pluta. "Preservation of Biomarkers Associated with Alzheimer’s Disease (Amyloid Peptides 1-38, 1-40, 1-42, Tau Protein, Beclin 1) in the Blood of Neonates after Perinatal Asphyxia." International Journal of Molecular Sciences 24, no. 17 (2023): 13292. http://dx.doi.org/10.3390/ijms241713292.

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Perinatal asphyxia is a complex disease involving massive death of brain cells in full-term newborns. The most impressive consequence of perinatal asphyxia is a neurodegenerative brain injury called hypoxic–ischemic encephalopathy. Management of newborns after perinatal asphyxia is very difficult due to the lack of measurable biomarkers that would be able to assess the severity of the brain injury in the future, help in the selection of therapy, assess the results of treatment and determine the prognosis for the future. Thus, these limitations make long-term neurodevelopmental outcomes unpredi

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8

Kántor, Tibor, Bianca Grigorescu, Gabriel Popescu, et al. "Traumás asphyxia maradandó látásvesztéssel." Orvosi Hetilap 158, no. 22 (2017): 864–68. http://dx.doi.org/10.1556/650.2017.30750.

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Abstract: Traumatic asphyxia is a rare condition that occurs after compressive thoracoabdominal trauma, which is characterized by subconjunctival hemorrhage, cervicofacial cyanosis, edema and petechiae. Serious life-threatening thoracic and abdominal injuries may coexist. After conservatory treatment in most cases complete recovery is achieved, but in isolated cases permanent neurological lesions may occur. We present the case of the 39-year-old male patient who suffered a compressive thoracoabdominal trauma. The physical examination showed the characteristic “ecchymotic mask”. After surgical

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9

Khare, Atul Kumar, Kirti Singh, Ashish Paliwal, and Richa Sharma. "How serum magnesium level is related to severity of asphyxia." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 13, no. 7 (2024): 1713–20. http://dx.doi.org/10.18203/2320-1770.ijrcog20241764.

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Background: Perinatal asphyxia is a most common cause of neonatal death. Magnesium, the second most common intracellular cation, may play a role in neuroprotection. Methods: This observational study was undertaken in the Department of Gynecology and Pediatrics in GMC, Shahdol from January 2021 to June 2023. The term babies were included with congenital anomaly, diabetic mother, IUGR, and mother receiving magnesium therapy during labour were excluded. Data analysis was conducted using IBM SPSS statistical software (version 22.0). Results: Out of 46 newborns, mild to moderated asphyxia and sever

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Parfenova, Helena, Massroor Pourcyrous, Alex L. Fedinec, Jianxiong Liu, Shyamali Basuroy, and Charles W. Leffler. "Astrocyte-produced carbon monoxide and the carbon monoxide donor CORM-A1 protect against cerebrovascular dysfunction caused by prolonged neonatal asphyxia." American Journal of Physiology-Heart and Circulatory Physiology 315, no. 4 (2018): H978—H988. http://dx.doi.org/10.1152/ajpheart.00140.2018.

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Neonatal asphyxia leads to cerebrovascular disease and neurological complications via a mechanism that may involve oxidative stress. Carbon monoxide (CO) is an antioxidant messenger produced via a heme oxygenase (HO)-catalyzed reaction. Cortical astrocytes are the major cells in the brain that express constitutive HO-2 isoform. We tested the hypothesis that CO, produced by astrocytes, has cerebroprotective properties during neonatal asphyxia. We developed a survival model of prolonged asphyxia in newborn pigs that combines insults of severe hypoxia, hypercapnia, and acidosis while avoiding ext

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11

Falasifah Ani Yuniarti, Athaya Intan Fitriani, and Yetty Purnamaningsih. "Case Report: The Effect of Murottal Therapy of Surah Ar-Rahman on the Stability of Vital Signs in Infants with Severe Asphyxia." International Journal Of Health Science 5, no. 2 (2025): 21–27. https://doi.org/10.55606/ijhs.v5i2.5079.

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Neonatal asphyxia is a critical condition and one of the leading causes of neonatal mortality, especially in developing countries such as Indonesia. This condition is marked by impaired oxygen exchange, leading to hypoxemia, hypercapnia, and metabolic acidosis. Prompt and appropriate management is essential, including the use of non-pharmacological interventions such as Qur’anic murottal therapy. Surah Ar-Rahman is often chosen for its soft and soothing rhythm, which is believed to have a calming physiological effect on infants. This study used a case study design with an interventional approa

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Locci, Emanuela, Giovanni Bazzano, Roberto Demontis, Alberto Chighine, Vassilios Fanos, and Ernesto d’Aloja. "Exploring Perinatal Asphyxia by Metabolomics." Metabolites 10, no. 4 (2020): 141. http://dx.doi.org/10.3390/metabo10040141.

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Brain damage related to perinatal asphyxia is the second cause of neuro-disability worldwide. Its incidence was estimated in 2010 as 8.5 cases per 1000 live births worldwide, with no further recent improvement even in more industrialized countries. If so, hypoxic-ischemic encephalopathy is still an issue of global health concern. It is thought that a consistent number of cases may be avoided, and its sequelae may be preventable by a prompt and efficient physical and therapeutic treatment. The lack of early, reliable, and specific biomarkers has up to now hampered a more effective use of hypoth

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13

Prakash, Raj, M. R. Savitha, and B. Krishnamurthy. "Neurodevelopmental Outcome at 12 Months of Postnatal Magnesium Sulphate Therapy for Perinatal Asphyxia." Journal of Nepal Paediatric Society 36, no. 3 (2017): 256–62. http://dx.doi.org/10.3126/jnps.v36i3.15565.

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Introduction: Postnatal magnesium therapy has been proposed as a novel neuroprotective agent for perinatal asphyxia. A few studies reported short term neurological benefit with magnesium. It is uncertain whether magnesium therapy has any long term effect on neurodevelopment.Material and Methods: We randomly assigned 120 term asphyxiated infants to receive either magnesium sulphate infusion or placebo postnatally in first 48 hours of life. Babies were treated as per the standard treatment protocol for asphyxia. Short term outcome at discharge was previously reported and a follow up evaluation a

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14

Manole, Mioara D., Patrick M. Kochanek, Lesley M. Foley, et al. "Polynitroxyl Albumin and Albumin Therapy after Pediatric Asphyxial Cardiac Arrest: Effects on Cerebral Blood Flow and Neurologic Outcome." Journal of Cerebral Blood Flow & Metabolism 32, no. 3 (2011): 560–69. http://dx.doi.org/10.1038/jcbfm.2011.165.

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Postresuscitation cerebral blood flow (CBF) disturbances and generation of reactive oxygen species likely contribute to impaired neurologic outcome after pediatric cardiac arrest (CA). Hence, we determined the effects of the antioxidant colloid polynitroxyl albumin (PNA) versus albumin or normal saline (NS) on CBF and neurologic outcome after asphyxial CA in immature rats. We induced asphyxia for 9 minutes in male and female postnatal day 16 to 18 rats randomized to receive PNA, albumin, or NS at resuscitation from CA or sham surgery. Regional CBF was measured serially from 5 to 150 minutes af

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15

Amin, Tahsinul, Asim Kumar Shaha, and Ayesha Najma Nur. "Use of Prophylactic Phenobarbitone for Prevention of Morbidity and Mortality in Term Neonates Following Perinatal Asphyxia." Bangladesh Journal of Child Health 41, no. 3 (2018): 165–69. http://dx.doi.org/10.3329/bjch.v41i3.36952.

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Background: Seizures are common following perinatal asphyxia and may exacerbate secondary neuronal injury. Barbiturate therapy has been used for infants with perinatal asphyxia in order to prevent seizures. However, barbiturate therapy may adversely affect neurodevelopment leading to concern regarding its aggressive use in neonates. The objective of the study was to determine the effect of administering prophylactic barbiturate therapy on seizure control and mortality in term neonates following perinatal asphyxia.Methodology: This was a randomized controlled trial (RCT) of prophylactic phenoba

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Evsyukova, Inna I. "Сerebral oxymetry in neonatology". Pediatrician (St. Petersburg) 8, № 4 (2017): 86–91. http://dx.doi.org/10.17816/ped8486-91.

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The frequency of disturbance the functional development of newborn brain after intrauterine and birth asphyxia determines the necessity the finding objective methods of timely diagnosis the alteration of brain oxygenation for the target therapy. During last years the special attention of investigators was attracted to use for this purpose in newborns the noninvasive, informative and portable method near-infrared spectroscopy (NIRS). Cerebral oxymetry successfully used for estimation brain circulation of the blood and blood volume in the brain vessels with combination constant monitoring blood

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17

Sah, B., BN Yadav, and S. Jha. "A case report of Traumatic Asphyxia." Journal of College of Medical Sciences-Nepal 10, no. 3 (2015): 51–55. http://dx.doi.org/10.3126/jcmsn.v10i3.12777.

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Traumatic asphyxia is a condition presenting with cervicofacial cyanosis and edema, subconjunctival hemorrhage, and petechial hemorrhages of the face, neck, and upper chest that occurs due to a compressive force to the thoracoabdominal region.In this case report a 52 years old lady who was brought to the mortuary because of death due to traumatic asphyxia as a result of being stampeded by her own cows upon her chest was discussed. Congestion on both the conjunctiva, cyanosis on chin and adjacent upper left side of neck found with a well demarcated area observed between the cyanosed area over f

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18

Bezhenar, Vitaly F., Lidiia A. Ivanova, Dmitry O. Ivanov, and Olga L. Krasnogorskaya. "Amniotic fluid is a marker of the condition of the fetus. Is it so?" Pediatrician (St. Petersburg) 13, no. 6 (2023): 5–16. http://dx.doi.org/10.17816/ped1365-16.

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BACKGROUND: In the presence of meconium in the amniotic fluid, childbirth is usually classified as a high-risk group, which leads to an expansion of indications for operative delivery. Also in the literature there are indications of an increase in the frequency of the birth of a child in a state of asphyxia, with premature rupture of amniotic fluid. AIM: The aim of this study is to determine the significance of the influence of meconium color of amniotic fluid and the duration of the anhydrous period on the birth of a child in a state of asphyxia. MATERIALS AND METHODS: A retrospec

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Koehler, Raymond C., Zeng-Jin Yang, Jennifer K. Lee, and Lee J. Martin. "Perinatal hypoxic-ischemic brain injury in large animal models: Relevance to human neonatal encephalopathy." Journal of Cerebral Blood Flow & Metabolism 38, no. 12 (2018): 2092–111. http://dx.doi.org/10.1177/0271678x18797328.

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Perinatal hypoxia-ischemia resulting in death or lifelong disabilities remains a major clinical disorder. Neonatal models of hypoxia-ischemia in rodents have enhanced our understanding of cellular mechanisms of neural injury in developing brain, but have limitations in simulating the range, accuracy, and physiology of clinical hypoxia-ischemia and the relevant systems neuropathology that contribute to the human brain injury pattern. Large animal models of perinatal hypoxia-ischemia, such as partial or complete asphyxia at the time of delivery of fetal monkeys, umbilical cord occlusion and cere

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20

Lee, Jennifer K., Andrea Poretti, Jamie Perin, et al. "Optimizing Cerebral Autoregulation May Decrease Neonatal Regional Hypoxic-Ischemic Brain Injury." Developmental Neuroscience 39, no. 1-4 (2016): 248–56. http://dx.doi.org/10.1159/000452833.

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Background: Therapeutic hypothermia provides incomplete neuroprotection for neonatal hypoxic-ischemic encephalopathy (HIE). We examined whether hemodynamic goals that support autoregulation are associated with decreased brain injury and whether these relationships are affected by birth asphyxia or vary by anatomic region. Methods: Neonates cooled for HIE received near-infrared spectroscopy autoregulation monitoring to identify the mean arterial blood pressure with optimized autoregulatory function (MAPOPT). Blood pressure deviation from MAPOPT was correlated with brain injury on MRI after adju

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MATEEN, M., E. ROSHAN, MK HAYYAT, M. AFTAB, T. NASRIN, and SB KHAN. "ROLE OF MANNITOL IN IMPROVING THE OUTCOMES OF MODERATE TO SEVERE PERINATAL ASPHYXIA." Pakistan Journal of Intensive Care Medicine 5, no. 01 (2025): 47. https://doi.org/10.54112/pjicm.v5i01.47.

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Background: Birth asphyxia, defined as inadequate oxygen supply to a newborn during delivery, is a major cause of neonatal morbidity and mortality, second only to sepsis. While its incidence in developed countries ranges from 1% to 1.5% of live births, it rises significantly in developing nations, reaching up to 5%. Effective management of moderate to severe birth asphyxia remains a challenge. This study evaluates the efficacy of Mannitol infusion in improving survival outcomes in neonates diagnosed with moderate to severe perinatal asphyxia. Objective: To assess the effectiveness of Mannitol

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Levene, Malcolm I., David J. Evans, Su Mason, and Julia Brown. "An international network for evaluating neuroprotective therapy after severe birth asphyxia." Seminars in Perinatology 23, no. 3 (1999): 226–33. http://dx.doi.org/10.1016/s0146-0005(99)80067-6.

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Chandrasekaran, Suja Angelin, Hima B. John, Benjamin Jeyanth Ross, Asha Arumugam, Indira Balan, and Reema Samuel. "Parental Experiences of Neonatal Follow-up for Infants With Hypoxic Ischemic Encephalopathy in India: A Qualitative Study." American Journal of Occupational Therapy 77, Supplement_2 (2023): 7711510298p1. http://dx.doi.org/10.5014/ajot.2023.77s2-po298.

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Abstract Date Presented 04/22/2023 Low follow up rate of infants with perinatal asphyxia leads to inefficient early intervention of these children in developing countries. The reasons for this are discovered in this study and can be applied to improve the rate of follow up and therapy Primary Author and Speaker: Suja Angelin Chandrasekaran Contributing Authors: Hima B John, Benjamin Jeyanth Ross, Asha Arumugam, Indira Balan, Reema Samuel

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Notarbartolo, Veronica, Bintu Ayla Badiane, Vita Maria Angileri, Ettore Piro, and Mario Giuffrè. "Antioxidant Therapy in Neonatal Hypoxic Ischemic Encephalopathy: Adjuvant or Future Alternative to Therapeutic Hypothermia?" Metabolites 14, no. 11 (2024): 630. http://dx.doi.org/10.3390/metabo14110630.

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Background: Oxidative stress-related diseases in newborns arise from pro-oxidant/antioxidant imbalance in both term and preterm neonates. Pro-oxidant/antioxidant imbalance has shown to be present in different pathological conditions such as hypoxic ischemic encephalopathy (HIE), retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), and patent ductus arteriosus (PDA). Methods and Results: We performed a narrative review according to the most recent available literature (2012–2024), using Scopus and PubMed as electronic databases. Many observational

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Kletkiewicz, Hanna, Maciej Klimiuk, Alina Woźniak, Celestyna Mila-Kierzenkowska, Karol Dokladny, and Justyna Rogalska. "How to Improve the Antioxidant Defense in Asphyxiated Newborns—Lessons from Animal Models." Antioxidants 9, no. 9 (2020): 898. http://dx.doi.org/10.3390/antiox9090898.

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Oxygen free radicals have been implicated in brain damage after neonatal asphyxia. In the early phase of asphyxia/reoxygenation, changes in antioxidant enzyme activity play a pivotal role in switching on and off the cascade of events that can kill the neurons. Hypoxia/ischemia (H/I) forces the brain to activate endogenous mechanisms (e.g., antioxidant enzymes) to compensate for the lost or broken neural circuits. It is important to evaluate therapies to enhance the self-protective capacity of the brain. In animal models, decreased body temperature during neonatal asphyxia has been shown to inc

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Maharani, Ni Luh Putu, Ekawaty Lutfia Haksari, and I. Wayan Dharma Artana. "Risk factors for hearing loss in neonates." Paediatrica Indonesiana 55, no. 6 (2016): 328. http://dx.doi.org/10.14238/pi55.6.2015.328-32.

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Background An estimated 6 of 1,000 children with live birthssuffer from permanent hearing loss at birth or the neonatal period.At least 90% of cases occur in developing countries. Hearing lossshould be diagnosed as early as possible so that intervention canbe done before the age of 6 months.Objective To determine risk factors for hearing loss inneonates.Methods We performed a case-control study involving 100neonates with and without hearing loss who were born atSanglah Hospital, Denpasar from November 2012 to February2013. Subjects were consisted of 2 groups, those with hearingloss (case group

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Herzog, D., P. Chessex, S. Martin, and F. Alvarez. "Transient Cholestasis in Newborn Infants with Perinatal Asphyxia." Canadian Journal of Gastroenterology 17, no. 3 (2003): 179–82. http://dx.doi.org/10.1155/2003/108473.

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In asphyxiated newborn infants, cholestasis often leads to extensive investigations and a cause can rarely be found.OBJECTIVE: To assess the frequency of transient neonatal cholestasis in an unselected group of asphyxiated newborn infants in a mother-child centre.METHOD: Charts of 181 asphyxiated newborn infants born with appropriate birth weight for gestational age (AGA) or small weight for gestational age (SGA) at Sainte-Justine Hospital, Montreal, Quebec between 1989 and 1993 were reviewed.RESULTS: Transient neonatal cholestasis was found in 8.5% of asphyxiated AGA and 33% of SGA newborn in

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Goldberg, Ronald N., Pedro Moscoso, Charles R. Bauer, et al. "Use of barbiturate therapy in severe perinatal asphyxia: A randomized controlled trial." Journal of Pediatrics 109, no. 5 (1986): 851–56. http://dx.doi.org/10.1016/s0022-3476(86)80713-2.

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Prawoto, Olivia Listiowati, Tjokorda Gde Agung Suwardewa, I. Made Darmayasa, Putu Doster Mahayasa, I. Nyoman Bayu Mahendra, and Evert Solomon Pangkahila. "Modified Foam Stability Test (Fs-50) as Predictor of Fetal Lung Maturity in Preterm Premature Rupture of Membrane Patients Given Dexamethasone Therapy." Jurnal Health Sains 4, no. 5 (2023): 105–16. http://dx.doi.org/10.46799/jhs.v4i5.906.

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This study aims to determine the ability of the Modified Foam Stability (FS-50) test to predict fetal lung maturity in preterm premature rupture of membranes treated with Dexamethasone. The study sample included pregnant women with PROM at a gestational age of 24 to less than 34 weeks in the ER and Obstetrics Ward of Sanglah Central General Hospital, Denpasar. The patient underwent a vaginal speculum examination to collect fluid pooled in the vagina or from the outer cervical opening. Fluids are checked with the Modified Foam Stability (FS-50) test and graded from 0 to +4 to estimate fetal lun

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Vannucci, Robert C. "Current and Potentially New Management Strategies for Perinatal Hypoxic-Ischemic Encephalopathy." Pediatrics 85, no. 6 (1990): 961–68. http://dx.doi.org/10.1542/peds.85.6.961.

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Given the current dilemma in the brain-oriented therapy of newborn infants sustaining cerebral hypoxia-ischemia, it is not surprising that management strategies vary widely among neonatal intensive care units.9 Thus, there is no uniform standard of care, and it remains for future research to uncover new and effective modes of therapy for the neurologically compromised infant. Prevention, or at least optimal management, of prepartum and intrapartum asphyxia remains the best available means of reducing the incidence and severity of peninatal hypoxic-ischemic brain damage.

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Rahman, Farhana, Md Abu Bakar Siddique, Md Wahidul Hassan, Md Nasimul Bari, and Firoz Ahmed. "A Study on Electrolyte Imbalance in Asphyxiated Neonates." KYAMC Journal 7, no. 2 (2017): 775–79. http://dx.doi.org/10.3329/kyamcj.v7i2.33837.

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In less developed country like Bangladesh, perinatal asphyxia remains a major cause of death and disability. Disorders of electrolytes are one of the common derangements encountered in critically ill asphyxiated neonates. It may remain unrecognized leading to morbidity and mortality irrespective of the primary problem. Syndrome of inappropriate secretion of ADH (SIADH) causes hyponatraemia in perinatal asphyxia. Metabolic acidosis may further exaggerate hyponatraemia. Where as in hypernatraemia there is an absolute or relative deficit of water in relation to body sodium. Hyponatraemia and hype

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Wintermark, Pia. "Current Controversies in Newer Therapies to Treat Birth Asphyxia." International Journal of Pediatrics 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/848413.

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Despite major advances in monitoring technology and knowledge of fetal and neonatal pathophysiology, neonatal hypoxic-ischemic encephalopathy (HIE) remains one of the main causes of severe adverse neurological outcome in children. Until recently, there were no therapies other than supportive measures. Over the past several years, mild hypothermia has been proven to be safe to treat HIE. Unfortunately, this neuroprotective strategy seems efficient in preventing brain injury in some asphyxiated newborns, but not in all of them. Thus, there is increasing interest to rapidly understand how to refi

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Calisici, Erhan, Mehmet Yekta Oncel, Halil Degirmencioglu, et al. "A Neonate with Subcutaneous Fat Necrosis after Passive Cooling: Does Polycythemia Have an Effect?" Case Reports in Pediatrics 2013 (2013): 1–3. http://dx.doi.org/10.1155/2013/254089.

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Subcutaneous fat necrosis (SCFN) is an inflammatory disorder of adipose tissue. The main risk factors for the development of SCFN are perinatal asphyxia and hypothermia. Presented here is a case of a newborn who developed SCFN in association with polycythemia and hypocalcemia following treatment by passive cooling. Neonates who undergo passive or whole body cooling therapy should be closely monitored for any signs of SCFN.

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Ovčarenko, Sergej, Viktorija Danilova, and Violeta Kalnicka. "Changes in the level of interleukin-4 and interleukin-6 in response to angioprotective therapy in children with severe birth asphyxia." Medicinski casopis 54, no. 1 (2020): 18–22. http://dx.doi.org/10.5937/mckg54-25065.

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Objective. The development of clinical and laboratory criteria for diagnosis of systemic inflammatory response significantly expanded the use of this concept in clinical practice. The correlation between the levels of antiinflammatory and pro-inflammatory cytokines is an important aspect in regulation of systemic inflammatory response. Treatment of systemic inflammatory response includes three main links: effect on the levels of endotoxin, cytokines and the state of endothelium. Currently there is no unified approach to the solution of this problem, which determines the relevance of the topic.

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Saraceno, Gustavo Ezequiel, María Laura Aón Bertolino, Pablo Galeano, Juan Ignacio Romero, Luis Miguel Garcia-Segura, and Francisco Capani. "Estradiol therapy in adulthood reverses glial and neuronal alterations caused by perinatal asphyxia." Experimental Neurology 223, no. 2 (2010): 615–22. http://dx.doi.org/10.1016/j.expneurol.2010.02.010.

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Clark, Robert, and Joseph A. Carcillo. "Is it time to revisit a role for antithrombotic therapy in asphyxia neonatorum? *." Pediatric Critical Care Medicine 5, no. 2 (2004): 198–99. http://dx.doi.org/10.1097/01.pcc.0000121302.62216.d6.

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van Wincoop, Maureen, Karen de Bijl-Marcus, Marc Lilien, Agnes van den Hoogen, and Floris Groenendaal. "Effect of therapeutic hypothermia on renal and myocardial function in asphyxiated (near) term neonates: A systematic review and meta-analysis." PLOS ONE 16, no. 2 (2021): e0247403. http://dx.doi.org/10.1371/journal.pone.0247403.

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Background Therapeutic hypothermia (TH) is a well-established neuroprotective therapy applied in (near) term asphyxiated infants. However, little is known regarding the effects of TH on renal and/or myocardial function. Objectives To describe the short- and long-term effects of TH on renal and myocardial function in asphyxiated (near) term neonates. Methods An electronic search strategy incorporating MeSH terms and keywords was performed in October 2019 and updated in June 2020 using PubMed and Cochrane databases. Inclusion criteria consisted of a RCT or observational cohort design, interventi

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Islas-Fabila, P., H. Orozco-Gregorio, P. Roldan-Santiago, et al. "Treatments and therapeutic protocols for the recovery of an asphyxiated new-born: A review of pre-clinical and clinical studies in human neonates and in different animal models." Veterinární Medicína 67, No. 6 (2022): 271–97. http://dx.doi.org/10.17221/43/2021-vetmed.

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The objective of this review is to ascertain the advantages and disadvantages of several treatments and therapeutic protocols that have been used for the prevention and treatment of perinatal asphyxia in human neonates and in different animal models. Perinatal asphyxia is one of the main causes of mortality worldwide and is an important factor in triggering physio-metabolic disorders that result in serious neurological consequences and learning disorders not only in human foetuses and neonates, but also in animals. In recent years, the search for new pharmacological protocols to prevent and re

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Dr., Sundas Anjum Dr. Maria Riffat Dr. Shehzina Nawal. "A RESEARCH STUDY ON THE ASSESSMENT OF THE REASONS OF ACUTE KIDNEY FAILURE IN NEONATES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 9456–60. https://doi.org/10.5281/zenodo.2730090.

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<strong><em>Objective: </em></strong><em>Acute kidney failure (AKF) is very frequent disorder among the admitted newborns in the ICU. In majority of patients, acute kidney failure goes together with a prompting factor like sepsis, failure of heart, perinatal asphyxia and/or prematurity. This research work aimed to find out the reasons and consequences of AKF in the neonates getting treatment in the hospital.</em> <strong><em>Methodology: </em></strong><em>This is an elaborate transverse research work. In this study, we assessed the newborns suffering admitted in DHQ Hospital, Faisalabad from A

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Millán, Iván, José Piñero-Ramos, Inmaculada Lara, Anna Parra-Llorca, Isabel Torres-Cuevas, and Máximo Vento. "Oxidative Stress in the Newborn Period: Useful Biomarkers in the Clinical Setting." Antioxidants 7, no. 12 (2018): 193. http://dx.doi.org/10.3390/antiox7120193.

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Aerobic metabolism is highly efficient in providing energy for multicellular organisms. However, even under physiological conditions, an incomplete reduction of oxygen produces reactive oxygen species and, subsequently, oxidative stress. Some of these chemical species are highly reactive free radicals capable of causing functional and structural damage to cell components (protein, lipids, or nucleotides). Oxygen is the most used drug in ill-adapted patients during the newborn period. The use of oxygen may cause oxidative stress-related diseases that increase mortality and cause morbidity with

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Choudhary, Mukesh, Deepak Sharma, Dhanraj Dabi, Mamta Lamba, Aakash Pandita, and Sweta Shastri. "Hepatic Dysfunction in Asphyxiated Neonates: Prospective Case-Controlled Study." Clinical Medicine Insights: Pediatrics 9 (January 2015): CMPed.S21426. http://dx.doi.org/10.4137/cmped.s21426.

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Objective This study was performed to determine the occurrence of hypoxic hepatitis in full-term neonates after perinatal asphyxia and to correlate between the rise in enzymes and severity of asphyxia with Apgar score and hypoxic ischemic encephalopathy (HIE) grading of the neonates. Method and Material This prospective case-controlled study was conducted in a tertiary-level hospital in India for a period of 12 months. The study group A comprised 70 newborns suffering from birth asphyxia, while 30 healthy neonates were included in group B (control). All biochemical parameters of liver function

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Safar, Peter. "Resuscitation Research Programs in Three Spheres." Prehospital and Disaster Medicine 1, S1 (1985): 4–6. http://dx.doi.org/10.1017/s1049023x00043600.

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Research on acute dying processes, emergency resuscitation (cardiopulmonary-cerebral resuscitation, CPCR) and long-term resuscitation (intensive therapy) have the potential of leading to so far unimagined restoration of total body function, including human mentation, after sudden cardiac death from ventricular fibrillation, asphyxia or exsanguination; and also after prolonged terminal states from trauma or other insults—conditions which have so far been considered irreversible. Since the 1950's, an increasing number of investigators have embarked on resuscitation-related research.

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Samudro, Heru, and Mulyadi M. Djer. "Inhaled iloprost as part of combination therapy for persistent pulmonary hypertension of the newborn." Paediatrica Indonesiana 52, no. 1 (2012): 57. http://dx.doi.org/10.14238/pi52.1.2012.57-60.

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Persistent pulmonary hypertension of thenewborn (PPHN) is rare, but life-threatening.If not treated, PPHN may cause respiratoryfailure and death in neonates. l,2,3 PPHNoften occurs in term or post-term infants with a historyof difficult labor, infection or asphyxia during birth.These infants do not have adequate oxygen duringlabor.3 Based on etiology, PPHN can be categorizedinto primary PPHN, which occurs by itself withoutapparent cause; or secondary PPHN, which is causedby meconium aspiration, hyaline membrane disease,neonatal sepsis with pneumonia, congenital heartabnormality, or maternal dr

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Ge, Jingjing, Xiaoling Jiao, Fanlin Qi, and Hui Li. "Neural Function Recovery and Safety of Mild Hypothermia Therapy Combined with Monosialotetrahexosylganglioside on Neonatal Asphyxia Complicated by Hypoxic Ischemic Encephalopathy." Computational and Mathematical Methods in Medicine 2021 (December 27, 2021): 1–8. http://dx.doi.org/10.1155/2021/6186011.

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Objective. To explore the effect and safety of mild hypothermia therapy combined with monosialotetrahexosylganglioside (GM1) on neural function recovery of neonatal asphyxia complicated by hypoxic ischemic encephalopathy (HIE). Methods. The clinical data of 90 neonates with HIE were retrospectively analyzed. According to the treatment methods, the neonates were divided into a routine group, a mild hypothermia group, and a combination group, with 30 cases in each group. The differences in neural function recovery, biochemical indexes, clinical signs recovery, efficacy, and complications were ob

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Savelyeva, Savelyeva G. М., Shalina R. I. Shalina, Аnаnkina А. А. Аnаnkina, et al. "Controlled hypothermia in complex therapy for hypoxic ischemic encephalopathy in infants with birth asphyxia." Akusherstvo i ginekologiia 5_2020 (May 29, 2020): 90–97. http://dx.doi.org/10.18565/aig.2020.5.90-97.

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Goldberg, Ronald N., Frederick L. Bloom, Charles R. Bauer, et al. "1390 THE USE OF BARBITURATE THERAPY IN SEVERE PERINATAL ASPHYXIA: A RANDOMIZED CONTROLLED TRIAL." Pediatric Research 19, no. 4 (1985): 342A. http://dx.doi.org/10.1203/00006450-198504000-01414.

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Rocha-Ferreira, Eridan, Brogan Rudge, Michael P. Hughes, Ahad A. Rahim, Mariya Hristova, and Nicola J. Robertson. "Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/5763743.

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Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention that could be administered as an alternative to cooling in cases of perinatal hypoxia-ischemia (HI). In the current study we hypothesized that RIPostC in the piglet model of birth asphyxia confers protection by reducing nitrosative stress and subsequent nitrotyrosine formation, as well as having an effect on glial immunoreactivity. Postnatal day 1 (P1) piglets underwent HI brain injury and were randomised to HI (control) or HI + RIPostC. Immunohistochemistry assessment 48 hours after HI revealed a significant de

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Upendra, Prasad Sahu, Kumar Singh Bhuwan, and Narayan Prasad Kamal. "Prospective Observational Assessment of Hearing Impairment in Newborns Admitted to A Neonatal Intensive Care Unit (NICU) Study." International Journal of Pharmaceutical and Clinical Research 14, no. 1 (2022): 695–702. https://doi.org/10.5281/zenodo.13868496.

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<strong>Introduction: </strong>Hearing is essential for humans to communicate with one another. Early diagnosis of hearing loss and intervention in neonates and infants can reduce developmental problems. The aim of the present study was to assess the prevalence of hearing impairment in newborns admitted to a neonatal intensive care unit (NICU) and analyze the associated risk factors. <strong>Methods: </strong>Prospective observational study was conducted among neonates with birth asphyxia admitted to the NICU at RIMS, Ranchi, Jharkhand, India, from November 2020 to October 2021.

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Nagalo, Kisito, Laure Toguyeni, Sonia Douamba, et al. "Neonatal Respiratory Distress in a Poor Resource Setting: From Epidemiology to Outcome." Asian Journal of Pediatric Research 13, no. 4 (2023): 159–68. http://dx.doi.org/10.9734/ajpr/2023/v13i4305.

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Background: Neonatal respiratory distress one of the main causes of neonatal morbidity and mortality. It is a diagnostic and therapeutic emergency whose etiology is dominated by respiratory pathologies. Objective: To study the epidemiological, clinical, diagnostic, therapeutic, and outcomes aspects of neonatal respiratory distress in order to help reduce its impact on neonatal morbidity and mortality. Methods: A retrospective descriptive cross-sectional study covering the period from 1st January 2017 to 31 December 2018 was conducted in the Neonatology Unit of the Centre Hospitalie

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Popova, N. G., V. V. Kocherova, and M. V. Konteeva. "HYPERAMMONEMIA IN NEONATOLOGY: DIAGNOSTIC DIFFICULTIES, MANAGEMENT FEATURES." Transbaikalian Medical Bulletin, no. 2 (July 24, 2024): 152–60. http://dx.doi.org/10.52485/19986173_2024_2_152.

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There are primary and secondary hyperammonemia. Primary hyperammonemia is a hereditary disorder of the urea formation cycle. Secondary hyperammonemia can occur both in hereditary diseases (mitochondrial diseases, organic aciduria/aminoacidopathies) and in asphyxia suffered in childbirth, liver damage of various etiologies (toxic, infectious, etc.), extrahepatic portal hypertension, renal failure, infections caused by urease-producing microorganisms, diseases accompanied by increased catabolism, etc. transient nature. Regardless of the etiology, hyperammonemia can cause irreversible damage to b

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