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Journal articles on the topic 'Assignement'
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1
Barbanera, Franco, and Ugo de'Liguoro. "Type Assignement for Mobile Objects." Electronic Notes in Theoretical Computer Science 104 (November 2004): 25–38. http://dx.doi.org/10.1016/j.entcs.2004.09.020.
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Razzano, Giuseppe, Francesco Delli Priscoli, and Roberto Cusani. "Wireless LANs Systems: An Advanced Resource Assignement Algorithm." Wireless Personal Communications 39, no. 1 (August 5, 2006): 25–40. http://dx.doi.org/10.1007/s11277-006-9064-3.
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Smith, Macgregor, and Robert Macleod. "A Relaxed Assignment Algorithm For The Quadratic Assignement Problem." INFOR: Information Systems and Operational Research 26, no. 3 (January 1988): 170–90. http://dx.doi.org/10.1080/03155986.1988.11732062.
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Balys, Vaidas, and Rimantas Rudzkis. "Mokslinių terminų statistinio pasiskirstymo taikymas straipsnių klasifikavime." Lietuvos matematikos rinkinys 43 (December 22, 2003): 463–67. http://dx.doi.org/10.15388/lmr.2003.32508.
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Automatic keywords assignment is a way to solve the problem of classification of scientific information. Paper deals with idea of implementing this assignement by making use of models for distribution of scientific terms. Some analysis was carried out and on base of its results the conclusions about effectiveness, usefullnes, main shortages and the ways of refinement of simpliest algorithms are drawn. A need for better algorithms is motivated and some ideas about how to create them are proposed.
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Baliña, Fatima, and Vicente Quiton. "Factors Affecting Workload Distribution Among Academic Staff in ViSCA." Science and Humanities Journal 4 (December 1, 2004): 11–23. http://dx.doi.org/10.47773/shj.1998.041.2.
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The workload distribution of the academic staff was determined and the factors that influence its variability were identified. The ideal perceived workload of academic staff in the academic department was 56% in instruction, 24% in research and 17% in extension, while in the research centers, 32%, 43% and 24% for instruction, research and extension functions, respectively. The assignement given by the department heads and the number of approved research projects/extension activities handled/implemented by the staff had the most influence on the variability in workload distribution.
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Plentz, R. R., K. L. Rudolph, J. Bleck, M. Gebel, T. Kirchhoff, S. Kubicka, and M. P. Manns. "Prospective assignement of patients with non-resectable hepatocellular carcinoma to different therapies." Journal of Hepatology 38 (April 2003): 103–4. http://dx.doi.org/10.1016/s0168-8278(03)80415-4.
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Pepe, G., P. Vernole, L. Ferrucci, and G. Svampa. "Assignement of the fibronectin (FN1) gene to pongo pygmaeus (Organgutan) chromosome 11." Human Evolution 12, no. 3 (July 1997): 183–87. http://dx.doi.org/10.1007/bf02438067.
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Kühne, Lucas, and Paul Brinkkötter. "Ödeme – Kardinalsymptom des nephrotischen Syndroms." DMW - Deutsche Medizinische Wochenschrift 144, no. 06 (March 2019): 376–81. http://dx.doi.org/10.1055/a-0664-5507.
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AbstractEdema is a common symptom with mostly extrarenal causes. Nevertheless, it may also be a sign of glomerular disease. So renal causes should always be clarified to avoid serious complications, such as renal insufficiency, cardiovascular or thrombembolic events. The determination of the albumin-creatinine ratio in spot urine is easy to perform and the method of choice to diagnose nephrotic-range proteinuria. Renal biopsy then usually allows the definitive assignement to either glomerular or systemic disease. Salt restriction in combination with diuretics and antiproteinuric treatment are essential for an effective therapy. Depending on the underlying disease and individual risk factors, anticoagulation should also be considered.
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Ogata, H., N. Mizuno, K. Miki, S. Adachi, N. Yasuoka, T. Yagi, and Y. Higuchi. "Assignement of the substrate (hydrogen molecule) at the active site of [NiFe] hydrogenase." Seibutsu Butsuri 40, supplement (2000): S3. http://dx.doi.org/10.2142/biophys.40.s3_2.
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Beutel, R. G., W. W. Zhang, H. Pohl, T. Wappler, and M. Bai. "A miniaturized beetle larva in Cretaceous Burmese amber: reinterpretation of a fossil “strepsipteran triungulin”." Insect Systematics & Evolution 47, no. 1 (February 29, 2016): 83–91. http://dx.doi.org/10.1163/1876312x-46052134.
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A wingless and eyeless tiny fossil embedded in Cretaceous amber from Myanmar is described and interpreted phylogenetically as beetle larva, very likely belonging to a cucujiform group of Coleoptera with parasitic habits, probably the family Ripiphoridae. Features supporting this are the lobe-like terminal elements of the legs and the pattern of setae on the abdomen. However the larva display specialized features differing from immatures of extant ripiphorid species, such as for instance the absence of stemmata and the presence of ventral transverse rows of spines. An earlier tentative assignement of a similar larva embedded in Cretaceaous amber from Manitoba (Canada) to Strepsiptera is not followed here. We suggest that this larva is closely related to the beetle larva described here.
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Bai, Ming, Rolf Beutel, Wangang Liu, Sha Li, Mengna Zhang, Yuanyuan Lu, Keqing Song, Dong Ren, and Xing-Ke Yang. "Description of a new species of Glaresidae (Coleoptera: Scarabaeoidea) from the Jehol Biota of China with a geometric morphometric evaluation." Arthropod Systematics & Phylogeny 72, no. 3 (July 12, 2014): 223–36. http://dx.doi.org/10.3897/asp.72.e31787.
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Glaresis tridentata Bai, Beutel & Ren sp. nov. (Scarabaeoidea: Glaresidae) from the Yixian Formation of western Liaoning Province, NE China is described and illustrated. A geometric morphometric analysis of three character systems (head, metatibia and aedeagus) was carried out including 136 specimens from 44 species of three genera of extant and extinct Glaresidae. The variation in these features between Glaresis tridentata Bai, Beutel & Ren sp. nov. and the other species was estimated based on Principal Component Analysis (PCA), Canonical Variate Analysis (CVA), Discriminant function analysis (DFA) and Minimum Spanning Tree (MST) approaches. The results suggest that Glaresidae, likely the sister group of all other extant Scarabaeoidea, had been established in the Early Cretaceous and contained larger species than today. The assignement of the new species to the genus Glaresis is supported. The validity of the genera Lithoglaresis and Cretoglaresis is questionable.
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Mastilović, Anja. "ISSN i registracija digitalizovanih serijskih publikacija = ISSN and Registration of the Digitized Serial Publications." Bosniaca 21, no. 21 (December 2016): 54–58. http://dx.doi.org/10.37083/bosn.2016.21.54.
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Šta se dešava nakon digitalizacije građe, obrade digitalizovanog materijala, tačnije ocerovanja2? Kako se digi-talizovana serijska publikacija katalogizuje? Da li joj se dodjeljuje ISSN? Cilj rada je da objasni pravila dodjele ISSN broja digitalizovanoj građi, ko je može dobiti, te koja se polja dodaju zapisima digitalizovane građe u ISSN kataloškom programu (Virtua Integrated Library System). U radu će se dati primjeri digitalizovanih serijskih pu-blikacija kojima su dodijeljeni ISSN brojevi. = What happens after digitization, processing of digitized material, namely OCR? How is the digitized serial cata-loged? Is the ISSN assigned to it? The aim of the article is to explain ISSN assignement rules to the digitized ma-terials, who can get it, and which fields are added to the records of digitized material in ISSN cataloging program (Virtua Integrated Library System). This paper will give examples of digitized serials to which ISSN numbers are assigned.
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Sorokin, Peter P., and James H. Glownia. "Nonlinear spectroscopy in astronomy: assignement of diffuse interstellar absorption bands to L(α) -induced, two-photon absorption by H2 molecules." Chemical Physics Letters 234, no. 1-3 (March 1995): 1–6. http://dx.doi.org/10.1016/0009-2614(95)00099-p.
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ROUSSEL, FLORIAN, and IRENA RUSU. "HOLES AND DOMINOES IN MEYNIEL GRAPHS." International Journal of Foundations of Computer Science 10, no. 02 (June 1999): 127–46. http://dx.doi.org/10.1142/s0129054199000113.
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Many practical problems (frequency assignement, register allocation, timetables) may be formulated as graph (vertex-)coloring problems, but finding solutions for them is difficult as long as they are treated in the most general case (where the graph is arbitrary), since vertex coloring has been proved to be NP-complete. The problem becomes much easier to solve if the graph resulting from the modelisation of the practical application belongs to some particular class of graphs, for which solutions to the problem are known. Meyniel graphs form such a class (a fast coloring algorithm can be found in [9]), for which an efficient recognizing algorithm is therefore needed. A graph G=(V,E) is said to be a Meyniel graph if every odd cycle of G on at least five vertices contains at least two chords. Meyniel graphs generalize both i-triangulated and parity graphs, two well known classes of perfect graphs that will be present in our paper in Section 7. In [2], Burlet and Fonlupt propose a characterization of Meyniel graphs which relies on the following property: the class of Meyniel graphs may be obtained from some basic Meyniel graphs using a binary operation called amalgam. Besides the theoretical interest of this result, a practical interest arises because of the polynomial recognition algorithm which can be obtained. Unfortunately, it is quite expensive to verify if a given graph is the amalgam of two graphs (therefore the complexity of the whole algorithm is in O(n7)), and this supports the idea that a new point of view is needed to find a more efficient algorithm. Our approach of Meyniel graphs will be directed through the search of a general structure. Intuitively, a Meyniel graph either will be simple (i.e. with no hole or domino), or will have a skeleton around which the rest of the graph will be regularly organized. As suggested, the first type of Meyniel graphs is simple to identify. For the second type, a deeper analysis is necessary; it yields a characterization theorem, which is used to deduce the O(m2+mn) recognition algorithm.
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Borsuk, Yurii. "Topological analysis of roadway and railway networks of the Ukrainian-Polish borderlands (on the example of Lviv Oblast and Subcarpathian Voivodeship)." Journal of Geology, Geography and Geoecology 33, no. 1 (March 24, 2024): 44–53. http://dx.doi.org/10.15421/112405.
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The paper presents an analysis of functioning of roadway and railway networks in the context of logistics flows. The interaction of road vehicles and railroad cars within the given territories was characterized. The provided spatiotemporal modelling allows comparing the configuration of roadways and railways from the peripheral settlements to the regional capitals. The points that form transport links with the administrative centres of each studied territory were identified. A comparative topological analysis of the given lines of roadway and railway transport within the Ukrainian-Polish borderland employed quantitative (distance, time) and qualitative (curvature, travel speed) modelling parameters, characterizing the relationship of the borderland territories in two neighbouring countries of Eastern Europe. Relative indicators, which include curvature and speed, were estimated. A database of settlements based on accessibility to the city by road and rail transport was created, taking into account the top-10 centres of territorial communities, or hromadas, in Lviv Oblast and Subcarpathian Voivodeship. Alternative modes of transport for travelling from a centre of territorial community to the regional centre in Ukraine and Poland were highlighted. The study compared the settlements with low transport accessibility to the regional capital (oblast, voivodeship), taking into account the functioning of the roadway and railway networks. Social-geographical problems of the given territories were identified based on the analysis of topological indicators of each transport connections. I found that the network system of transport infrastructure in Subcarpathian Voivodeship is low-dense, especially in mountainous areas. Also, there was analyzed high accessibility of suburban settlements to the city of Rzeszów. In Lviv, connection between the suburbs and the city centre can be called problematic. Within the studied borderland areas, there were also found cases of disuse of the existing railway stations for passenger traffic. Variants that would promote the development of public transport in the Lviv Oblast have been proposed, based on the example of the transport model in Subcarpathian Voivodeship. Applied developments include the need to build the Opillia-Roztocze highway, assignement of high-speed electric trains from remote areas to the regional capital.
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Dmowski, Stanisław. "Własność działek budowlanych na terenach budownictwa jednorodzinnego i zagrodowego." Studia Prawnicze / The Legal Studies, no. 4 (66) (April 30, 2023): 63–117. http://dx.doi.org/10.37232/sp.1980.4.2.
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During the first years after World War Two housing needs of the population of the cities were first of all fulfilled from the resources administered by state organs. The participation of the population in building of houses was rather insignificant.Constantly diminishing housing resources and — on the other hand — grouth of industrial and agricultural production, caused the increase of real incomes of the population and changes in the state policy in the domain of building of houses, so as to include the iniciative and private funds of the population to the degree higher than thus far into the process of building.In order to carry out new haousing policy it was necessary to provide proper land for building, among others, for building of one family houses. This problem was to be solved by the law of July 6, 1972 on land designated for building one family houses and individual cultivation, and on division of real properties in towns and settlements (Journal of Laws n° 27 entry 192, changes in the Journal of Laws of 1973 n° 48 entry 282).This article aims at presenting all the problems pointed out in the title, and especially the problem of interpretation of several laconic provisions of te law of July 6, 1972. The article brings the reader’s attention to the fact that the law does not regulate all the issues connected with urban building because beyond its scope there remain some important general problems of administration of land in towns, problems of spatial planning, carrying out of industrial investments, building for communal purposes, construction of houses for many families by housing cooperative societies, etc. The article discusses administrative proceedings aimed at designation of land for the purposes of one family houses construction and for individual cultivation by workers of State or cooperative farms, as well as distribution of lots (declaration of preservation of ownership, assignement of lots in ownership or in perpetual usufruct). It also presents judicial proceedings and proceedings before state notarial offices in cases dealing with real properties and decisions designating land for purposes of such building.A critical opinion of the Author on several regulations contained in the law is also presented. Among others this concerns article 8 linea 3 which discriminates co-owners of real properties situated on building land if co-ownership, does not result from succession or cessation of joint property of husband and wife, and article 9 linea 1 which allows to assing a lot only to a young person of age or to a grandchild of the owner of real property which was included into the land designated for building.The final part contains some suggestions as to appropriateness of introducing some changes into the provisions now binding, also as far a appropriateness of regulating all the issues concerning land in the towns i one legal act.
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Terriou, L., R. Ben Abdelali, C. Roumier, J. de Vos, P. Cornillet, O. Nibourel, K. Beldjord, et al. "CEBPA Methylation and Notch1 Mutations Are Common in Immature T-ALLs but Not M0 AML and Cosegregate with TCRG Rearrangement and the TCRgd Lineage." Blood 110, no. 11 (November 16, 2007): 2788. http://dx.doi.org/10.1182/blood.v110.11.2788.2788.
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Abstract The CEBPA gene codes for the C/EBPa transcription factor which regulates hematopoietic stem cell homeostasis and orientates towards myeloid differentiation and against a T lymphoid fate. CEBPA silencing by promoter hypermethylation (CEBPAmeth) has recently been identified (Wouters, Blood 2007) in a minor subset of AML, all of which demonstrated T lymphoid features (expression of CD7 and CD3 transcripts, TCRG rearrangement and frequent NOTCH1 mutations (NOTCH1m)). These AML may be closer to immature T-ALLs, with CEBPa silencing and NOTCH1m determining lineage orientation. Although expression of CD7 and cytoplasmic CD3 (cCD3) are considered as defining markers in T-ALL, CD7 is commonly expressed in AML and reproducible multicenter detection of low level cCD3, when performed, can be difficult. We have classified CD7+, cCD3+ T-ALLs on the basis of their TCR profiles: immature cases arrested prior to TCRB VDJ rearrangement include TCRgd lineage precursors and can be divided into those with no TCR rearrangement (IM0), TCRd only rearrangement (IMD) or TCRd and TCRg rearrangement (IMG). The CALM-AF10 fusion transcript is found in both AML and T-ALL, where it is restricted to the TCRgd lineage. We initially searched for in CEBPAmeth by methylation specific PCR in 5 AML with downregulated CEBPand confirmed that the 3 cases (FAB-M0/M1) with CEBPAmeth expressed CD3, CD7 and/or TCRg rearrangement. Only 1/49 AML M0, all of which were cCD3 negative, demonstrated CEBPAmeth.We then searched for CEBPAmeth and mutation and NOTCH1m in 18 IM T-ALL (4 aged <15y; 5 IM0, 5 IMD, 8 IMG) compared to 6 adults with TCRB VDJ+, TCRab lineage T-ALL. No CEBPA mutations were found but 11/24 (56%) demonstrated CEBPAm and 10/23 (43%) NOTCH1m. Both correlated with IMG T-ALL, when 6/8 demonstrated CEBPAmeth and NOTCH1m and a seventh only NOTCH1m, compared to only 4/10 CEBPAmeth and 1/10 NOTCH1m in IM0/D cases, with no overlap. In ab-lineage T-ALLs 2/6 demonstrated NOTCH1m, one of which was also CEBPAmeth, and notably expressed TLX1/HOX11. CEBPAmeth cases were more frequently CALM-AF10+ (5/10), CD2-, CD123/IL3R-, HOXA9 transcript+ and IgH DJ rearranged but did not differ from non-CEBPAmeth T-ALL in CD34, CD5, CD117, CD13/33, CD79a or CD56 expression. As such CEBPAmeth is rare in cCD3- M0 AML but common in cCD3+ immature T-ALL, independently of myeloid antigen expression. CEBPAmeth and NOTCH1m in IM T-ALL are preferentially associated with cases having undergone TCRG rearrangement but are not found in the majority of more immature cases, demonstrating that CEBPAmeth is not necessary for CD7 and cCD3 expression, within a T-ALL context. It also suggests that CALM-AF10 should be searched for in CEBPAmeth AML, raises issues regarding AML vs. ALL protocol assignement and the use of demethylating agents in IMG T-ALLs and suggests that the potentially misleading “biphenotypic leukaemia” label be reassessed.
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Alegre, A., F. Lara, R. Gabriel, B. Aguado, L. M. Sánchez, S. Damiano, J. San Miguel, et al. "Epidemiology of Multiple Myeloma in Spain: An Analytic Review." Blood 106, no. 11 (November 16, 2005): 5089. http://dx.doi.org/10.1182/blood.v106.11.5089.5089.
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Abstract Introduction: Justification and Objectives There are little epidemiologic data about Myeloma Multiple in Spain. The heterogeneity and complexity of this pathology, and the several sociodemographic factors, justify the interest of this type of studies. On the other hand, this disease needs a high assignement of welfare and therapeutic resources, and besides new strategies have arisen for its treatment. The Spanish Leukaemia and Lymphoma Foundation (FLL)has analyzed the actual situation of Myeloma Multiple in Spain, compiling several epidemiologic and welfare parameters about the disease in a Multiple Myeloma “White Book” for Spain. Patients and Methods The period of analysis was 10 years, from 1.991 to 2.001. The information was compiled from a Hospital Based Survey about MM and the following official sources: International Agency for Research on Cancer (IARC): “Cancer incidence in Five continents” and “Incidence and Mortaliity for Cancer In Spain, Patterns and Tendences” Data Base of EUCAN and GLOBOCAN (Cancer Incidence, Mortality and Prevalence Worldwide) EUROCARE III study, (IARC Cancer Base Number 5, Lyon, IARCPress). “Natural Changes of Population and Demography. Spanish National Statistic Institute (INE) and National Spanish Center for Epidemiology (CNE.) Official Records for Mortality Rates by MM in Spain in Spanish Regions (CCAA) (death records Demograhy Records of INE). INE Hospital Case Rate Inquest. CMBD Data Base of Department of Health (Inmunoproliferative Neoplasm and Multiple Myeloma, CIE-9 Diagnosis Code: 203.0)The indicators used were: Deaths number, median of age, proportional mortality, mortality rates, mortality rates adjusted by age, gender and potential years of life lost due to multiple myeloma, (item 203 of ICD-10, OMS) during the last ten years in Spain. Results The incidence rates of MM, adjusted to the European population were: 3,54 cases by 100.000/year for men and 2,54 cases by 100.000/year for women. The global incidence rate were 4,44 cases by 100.000/year for men and 4,22 cases by 100.000/year for women. These rates were similar in all geographic regions. Performed predictions show a prevalence increase during the following five years, which means more than 2.400 cases in men and more than 2.100 in women MM cases per year. Regarding mortality, rates, myeloma is a very slightly frequent cause of death: 3.23 cases by 100.000/years of men and 2.3 cases of women. A whole an increase of mortality of 45.2 per cent was observed for the period of time between 1992 and 2001. Comments and Conclusions The MM incidence and mortality rates in Spain for this period were lower than expected in comparison with other European epidemiology studies. Nevertheless we observed that the MM mortality and prevalence rates present a continuous and uniform increment in the last years. Part of these increases can be due to the incorporation of new technologies, more sensitive for diagnosis, and to the increase of aging of the population. Furthermore certain occupational and chemical exposures and other environmental changes could explain these trends.
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Vlastou, R., C. T. Papadopoulos, C. A. Kalfas, S. Kossionides, L. Hildingsson, W. Klamra, Th Lindbland, C. G. Linden, and R. Wyss. "HIGH SPIN STRUCTURE OF 173Os." HNPS Proceedings 2 (February 18, 2020): 281. http://dx.doi.org/10.12681/hnps.2856.
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High-spin states in 173Os have been studied by γ-γ coincidence measurements following the 146Nd(32S,5n)173Os reaction. Four main sequences have been identified as the two signature branches of the bands built an the [642]5/2+ and [523]5/2- Nilsson states. Multi-polarity assignements have been derived utilizing the directional correlation (DCO) ratios aa well as the anisotropies of the γ-rays. B(M1)/B(E2) ratios have also been extracted to deduce farther information an the detailed structure of the bands
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Gaipa, Giuseppe, Cristina Bugarin, Sergio Matarraz, Chiara Buracchi, Lukasz Sedek, Vincent H. J. van der Velden, Tomasz Szczepanski, et al. "Euroflow-Based Immunophenotypic Characterization of CD34+ Cell Compartment in Juvenile Myelomonocytic Leukemia (JMML): A New Tool for Differential Diagnosis." Blood 128, no. 22 (December 2, 2016): 3127. http://dx.doi.org/10.1182/blood.v128.22.3127.3127.
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Abstract Background Juvenile myelomonocytic leukemia (JMML) is a lethal myeloproliferative disease (MPD) of young childhood characterized by an overproduction of myelomonocytic cells and an increased in vitro sensitivity of hematopoietic progenitors to granulocyte-macrophage colony-stimulating factor [GM-CSF] (Emanuel PD et al, Blood 1991). Diagnostic criteria for JMML are currently well-established and based on clinical features and laboratory findings. However, in some patients diagnosis of JMML vs other overlapping disease entities, still remains a challenge, immunophenotyping being not part of the diagnostic work-up of JMML. Here, we aimed at detailed characterization of the CD34+ cell compartment in JMML bone marrow (BM) using the standardized EuroFlow myeloid panel in combination with innovative EuroFlow software maturation tools. Our major goal was to determine the potential utility of immunophenotyping of CD34 cells in the diagnostic work-up of JMML. Methods Overall, we analyzed BM cells from 10 JMML patients at diagnosis (age range: 0-7 years), 17 control subjects (age range: 0-15 years) and 5 patients (age range: 0-5 years) with a suspected diagnosis of JMML that was subsequently not confirmed following standardized EuroFlow antibody combinations: 1) cyCD3/ CD45/ cyMPO/ cyCD79a/ CD34/ CD19 / CD7/smCD3 (for early lineage assignement); 2) HLADR/CD45/CD16/CD13/CD34/CD117/CD11b/CD10 (neutrophilic maturation); 3) HLADR/CD45/CD35/CD64/CD34/CD117/CD300e (IREM2)/CD14 (monocytic maturation); 4) HLADR/CD45/CD36/CD105/CD34/CD117/CD33/CD71 (erythroid vs plasmacytoid dendritic cell maturation). Samples were processed and analyzed according to the Euroflow standard operating protocols (van Dongen JJM et al, Leukemia 2012, Kalina T et al, Leukemia 2012). Data analysis was specifically focused on the immunophenotypic profile of CD34+ gated cells. Results Within the CD34+ BM cell compartment the proportion (mean % ± 1SD) of granulocytic and monocytic precursors were not significantly different in JMML as compared to controls: 33% ± 15% vs 25% ± 12% (p = 0.16) and 14% ± 6.3% vs 12% ± 7.1% (p = 0.68) respectively. Otherwise we observed a slightly decreased in erythroid CD34+ progenitors in JMML vs controls (1.0% ± 1.2% vs 2.8% ± 1.7%, p<0.05). Moreover, a significantly different distribution of lymphoid precursors was observed: B-cell precursors were strongly reduced in JMML vs controls (3.0% ± 3.5% vs 53% ± 16%, p<0.0001), while CD7+ lymphoid precursors resulted significantly enhanced (28% ± 18% vs 2.3% ± 1.2%, p<0.0001). We then investigated the presence of unusual immunophenotypes in JMML CD34+ BM cells, including CD7+/MPO+, CD79a+/CD7+, and CD79a+/MPO+ cells. Interestingly, we consistently found CD7+/MPO+ and/or CD79a+/CD7+ cells in 7/7 JMML patients analyzed (mean 7.9% ± 6.4%), while in control subjects these cells were virtually absent (0.02% ± 0.00%, p<0.0001). In contrast, no CD79a+/MPO+ cells were detected among CD34+ precursors. Those 5 patients suspected of having JMML showed a CD34+ BM cell immunophenotypic profile that was not significantly different from that of normal subjects. These patients were finally diagnosed as not having JMML (two had CMV infection, one a Leukocyte Adhesion Deficiency II, one a Noonan Syndrome, the final diagnosis is the other patient being still pending). Of note, JMML peripheral blood (PB) CD34+ cells from 6 JMML patients (3 paired BM-PB samples and 3 additional PB samples) fully confirmed the aberrant immunophenotypic signature seen in BM-derived samples. Conclusions CD34+ precursor cells from JMML patients display a unique immunophenotypic profile characterized by an inverted ratio of CD19+ B/CD7+ lymphoid precursors, associated with unusual marker coexpressions, which might contribute to fast and more precise diagnostic work-up of JMML. Further studies in larger patient series are required to confirm our observations. Disclosures Biondi: Novartis: Membership on an entity's Board of Directors or advisory committees, Other: Advisory Board; BMS: Membership on an entity's Board of Directors or advisory committees; Cellgene: Other: Advisory Board.
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Chatzilari, Elisavet, Panagiotis Baliakas, Aliki Xochelli, Anastasios Maronidis, Anna Vardi, Mattias Mattsson, Karin Larsson, et al. "Personalized Modeling of Disease Evolution in CLL: Does Statistical Significance Translate into Predictive Accuracy?" Blood 126, no. 23 (December 3, 2015): 2921. http://dx.doi.org/10.1182/blood.v126.23.2921.2921.
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Abstract The remarkable clinical heterogeneity of CLL has prompted several initiatives towards the development of prognostic models aiming to stratify patients into subgroups with distinct outcome. However, despite progress, the resultant prognostic models, mostly based on Cox regression analysis, have not been adopted in everyday clinical practice, mainly due to failure to provide sufficiently accurate predictions on a per patient basis. Here, we approached the issue of prognostication amongst Binet stage A CLL cases following a novel approach, in particular using Adaboost, an ensemble learning algorithm based on decision trees. Adaboost jointly considers all available parameters providing a specific prediction for each patient, unlike Cox regression models which are based on identifying parameters with independent prognostic significance. In addition, Adaboost models are completely automated with minimal time for training and prediction generation. This is in contrast to Cox models which are manually trained and require significantly more time for prediction generation. Both Cox regression and Adaboost models were evaluated regarding their predictive accuracy i.e. the number of patients successfully assigned to their true risk group divided by the total number of patients. For the development of the prognostic models, 5-fold cross-validation was used. The patients were equally subdivided into 5 subgroups. Each time, 4 out of the 5 subgroups were used to train the Cox regression and the Adaboost models while the 5th was kept as the validation cohort, where the models were applied to. The study cohort included 789 Binet A CLL patients with available data regarding gender, age, immunogenetic profile, CD38 expression, Döhner model cytogenetic aberrations and treatment status with a median follow up of 8.5 years (range 0-40.5 years, at least 5 years for untreated cases). Patients were subdivided in 3 groups: (i) high risk (HR): time-to-first-treatment (TTFT) <2 years, n=215 (27%); (ii) intermediate risk (IR): TTFT≥2 years and <5 years, n=151 (20%); and, (iii) low risk (LR): no need for treatment within 5 years from diagnosis, n=422 (53%). Applying Adaboost, the HR, IR and LR groups included 326 (41.5%), 0 (0%) and 463 (58.5%) cases, respectively. On multivariate analysis, unmutated IGHV genes U-CLL, subset #2 assignement and CD38 expression emerged as independently predictive of shorter TTFT; in contrast, adverse prognosis cytogenetic aberrations i.e. del(17p) and del(11q) did not retain significance (p=0.06 and 0.052, respectively), likely due to their strong association with U-CLL. Applying Cox regression models based on the significant independent parameters, patients were classified as follows: (i) HR: unmutated IGHV genes (U-CLL) and/or assignment to stereotyped subset #2 (n=357, 45%); (ii) IR: mutated IGHV genes (M-CLL) and high CD38 expression (CD38+) (n=41, 5%); and, (iii) LR: M-CLL and low CD38 expression (CD38-) (n=397, 50%). Prediction accuracies were 58.2% and 61.1% for the Cox regression and the Adaboost model, respectively (McNemar's test: p<0.0025). Both models often failed to identify patients belonging to the IR group. Further, we gave the same clinico-biological parameters used for the development of the prognostic models to 7 trained hematologists and asked them to assign each patient included in the study to one of the 3 risk groups. Among the trained hematologists, responses varied within the range of 51.2-58.4%, leading to an average prediction accuracy of 54.6%: particularly challenging was the discrimination between the HR vs the IR group. In conclusion, Adaboost outperforms to a small, yet statistically significant, degree the predictive accuracy of both Cox regression and expert judgment, suggesting its potential for clinical testing. However, the predictive accuracy rates of both the Adaboost and Cox regression approach are still unsatisfactory, highlighting that further development is required in order to provide robust personalized predictive modeling, while also suggesting that statistical significance does not automatically translate into clinical utility. This indicates the need for incorporating disease- and host-related parameters not yet evaluated for their prognostic/predictive value in CLL in order to refine risk stratification, thus meaningfully empowering physicians in clinical decision-making. Disclosures Niemann: Janssen: Consultancy; Roche: Consultancy; Gilead: Consultancy; Novartis: Other: Travel grant. Ghia:Janssen Pharmaceuticals: Research Funding.
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Enriquez, Alexis Arizabal. "Hurdling with the “New Normal”: Thoughts and Experiences of Parents on the Shape of their Children in the Academe." International Journal of Educational Review 4, no. 2 (August 31, 2022): 169–79. http://dx.doi.org/10.33369/ijer.v4i2.22118.
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This study is focused on the Thoughts and Experiences of Parents on the Shape of their Children in the Academe as they hurdle in the new normal. Specifically, it sought to analyze their thoughts on the ten questions posited on them that varied from safety of their children in school, module purchase and subsidy, optimum learning despite on the adopted learning system by the school, time to submit finished tasks of their children, academic freeze, and thoughts in case tehir children get sick. Findings included the following: Parents were doubtful as to safety of their children in the school yet, hopeful that through the skills, knowledge, and dedication of their reachers, optimum quality education could still be achieved regaredless of the learning modality which the school implements, subsidy of modules was strongly begged for since an allocation fro materials production is a priority of the school amidst this pandemic, academic freeze wa not an option to a majority, humane considerations from the teachers was a loud remark from parents. This allows their children to analyze, edit, and review materials and assignments. In conclusion, parents’ priority is education of their children that they need to purchase modules at all cost, hopeful that optimum learning and quality education could be achieved through the dedication and commitment of skilled and knowledgeable teachers. It is then recommended that the administration may want to consider conducting an orientation seminar to parents as to the new procedures, policies, modality for learning for teir children, Parents are also recommended to monitor and guide their children especially on the submission of finished tasks and other assignements.
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Wijaya, Ardi, Eka Sahputra, and Resnita Kornengsih. "Implementasi Resource Assignement Algorithm Pada Aplikasi Bahasa Latin Flora Dan Fauna Untuk Pelajar Berbasis Android." JURNAL MEDIA INFOTAMA 16, no. 1 (August 31, 2020). http://dx.doi.org/10.37676/jmi.v16i1.1123.
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Beberapa penelitian menyebutkan adanya masalah yang muncul dari aktifitas bermain game yang berlebihan, masalah tersebut adalah kehilangan kontol atas waktu dan mengalami kesulitan dalam hal akademis. Untuk menumbuhkan semangat belajar siswa, guru dituntut untuk membuat pembelajaran lebih menarik dan inovatif, usaha untuk mencapai pembelajaran yang menarik dan inovatif yaitu dengan menggunakan medi pembelajaran. Sulitnya belajar bahasa latin membuat anak kurang tertarik karena menggunakan bahasa yang sulit dimengerti serta diucapkan. Memanfaatkan mobile device sebagai media untuk belajar memberi kemudahan bagi pelajar untuk belajar secara praktis kapanpun dan dimanapun dengan mobile. Resource Assignment Algorithm (RAA) mempunyai kemampuan untuk menghasilkan sebuah nilai berdasarkan beberapa nilai yang ada dengan diurutkan menggunakan skala prioritas. Pada penerapannya aplikasi pengenalan bahasa latin flora dan fauna untuk pelajar SMP yang akan dihasilkan adalah nilai untuk mengeksekusi sebuah keputusan pada pelajar dalam menjawab sebuah pertanyaan dari pembelajaran bahasa latin flora dan fauna. Berdasarkan pengujian sistem dengan User Statisfaction Testing menunjukkan hasil 72% sangat menarik, 21% menarik dan 7% tidak menarik. Hasil ini menunjukkan rancangan aplikasi dinyatakan baik dan layak digunakan.
Kata Kunci : Aplikasi, Bahasa Latin, RAA, Android
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Schmidt, J. "Verkleinerung der Stellamplitude bei Führungsgrößenregelung durch Polvorgabe / Minimization of control amplitude with setpoint control by pole assignement." at - Automatisierungstechnik 34, no. 1-12 (January 1986). http://dx.doi.org/10.1524/auto.1986.34.112.208.
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Szpila, Krzysztof, Thomas van de Kamp, Elżbieta Sontag, Wiesław Krzemiński, Katarzyna Kopeć, and Agnieszka Soszyńska. "The hidden world of fossil larvae: description and morphological insights of an immature scorpionfly (Mecoptera: Panorpidae) from the Baltic amber." Zoological Journal of the Linnean Society, February 21, 2024. http://dx.doi.org/10.1093/zoolinnean/zlae009.
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Abstract So far, there has been no information of the pre-imaginal stages in the well-preserved fossil record of the Mecoptera. The first and well-preserved mecopteran larva was discovered in Eocene Baltic amber. The application of synchrotron X-ray microtomography enabled the reconstruction of the body structure with high accuracy, providing a comprehensive set of morphological data that classical stereoscopic microscopy could not capture. The larva is eruciform, with distinct segmentation of the body. All the most important morphological structures are documented, including the chaetotaxy system. Shape of antenna and annulated processes on the abdominal segments point to the third/four stage of development. There is no doubt that the larva belongs to Panorpidae, the most abundant family of extant Mecoptera. The morphological characters point to the closest affinity to larvae of Cerapanorpa and Panorpa but the fossil larva cannot be assigned to any extant genus of Panorpidae. Based on the results of synchrotron X-ray microtomography, it is possible to discuss the assignement of this larva to a lower systematic level than the family, and draw conclusions about the nature of the habitat preferences of Eocene panorpid.
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Bühler, H. "Minimierung der Norm des Rückführvektors bei der Polvorgabe / Minimization of the norm of the feedback vector with pole assignement." at - Automatisierungstechnik 34, no. 1-12 (January 1986). http://dx.doi.org/10.1524/auto.1986.34.112.152.
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Radosław Jan Strugała. "Zbywanie roszczeń o naprawienie szkody wyrządzonej czynem niedozwolonym. Ratio legis, treść normatywna oraz przyszłość uregulowania art. 449 KC." Forum Prawnicze 4, no. 54 (January 21, 2020). http://dx.doi.org/10.32082/fp.v4i54.216.
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The aim of the paper is to present an alternative interpretation of the article 449 of the Polish Civil Code. In contrast to the most common, literal interpretation thereof, the paper offers a purposive interpretation taking into account ratio legis of the provision at stake. This tool enables to cast away some interpretative doubts which are constantly raised in the literarure. For inastance, it leads to the conclusion that the acknowledgement of debt which (according to the article 449 of the Polish Civil Code) renders the claims for damages assignable shall be limited to the acknowledgement in the strict meaning of the term, that is to the acknowledgement understood as a contract between creditor and debtor, and shall determine a sum of the acknowledged claim. The paper concludes that the article 449 of the Polish Civil Code, thanks to its purposive interpretation, may effectively protect assignors from assigning their claims for damages for the price which is far lower than the value of damages to which the assignor was entitled. This conclusion put in the context of ongoing works on the new law regulating the compensation agencies makes the article 9 of this law (which exludes the possibility of assignement of claims for damages) redundant.
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Huba, Mikuláš, Milan Plechlo, and Pavol Bisták. "Nichtlineare Reglersynthese mit Polvorgabe und deren Anwendung auf Industrieroboter/ Non-linear controller synthesis with pole assignement and their use to industrial robots." at - Automatisierungstechnik 40, no. 8 (January 1, 1992). http://dx.doi.org/10.1515/auto-1992-0806.
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D’Azevedo Breda, Ana Maria, and José Manuel Dos Santos Dos Santos. "Learning complex functions with GeoGebra." Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales, November 23, 2021. http://dx.doi.org/10.18257/raccefyn.1504.
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In this paper we describe a teaching experiment targeting with students of Complex Analysis attending an undergraduate course of a portuguese university. Our main goal is the understanding of the GeoGebra role with respected to visualization and as technological mediator, according to Vygotsky theory, in the teaching and learning process of complex functions. The first step of our study was the conception of a sequence of didactical tasks and the development of GeoGebra tools related to the target didactical objectives. Here we will describe the procedure related to the tasks implementation in a classroom environment and the achieved results based on the collected data composed by written assignements produced by students, video recording the student performance during the experiment and the student constructions with GeoGebra. All the collected data was analysed from a qualitative and interpretative paradigm.
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Haddad-Boubaker, Sondes, Marwa Arbi, Oussema Souiai, Anissa Chouikha, Wasfi Fares, Kate Edington, Sam Sims, et al. "The Delta variant wave in Tunisia: Genetic diversity, spatio-temporal distribution and evidence of the spread of a divergent AY.122 sub-lineage." Frontiers in Public Health 10 (January 4, 2023). http://dx.doi.org/10.3389/fpubh.2022.990832.
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IntroductionThe Delta variant posed an increased risk to global public health and rapidly replaced the pre-existent variants worldwide. In this study, the genetic diversity and the spatio-temporal dynamics of 662 SARS-CoV2 genomes obtained during the Delta wave across Tunisia were investigated.MethodsViral whole genome and partial S-segment sequencing was performed using Illumina and Sanger platforms, respectively and lineage assignemnt was assessed using Pangolin version 1.2.4 and scorpio version 3.4.X. Phylogenetic and phylogeographic analyses were achieved using IQ-Tree and Beast programs.ResultsThe age distribution of the infected cases showed a large peak between 25 to 50 years. Twelve Delta sub-lineages were detected nation-wide with AY.122 being the predominant variant representing 94.6% of sequences. AY.122 sequences were highly related and shared the amino-acid change ORF1a:A498V, the synonymous mutations 2746T>C, 3037C>T, 8986C>T, 11332A>G in ORF1a and 23683C>T in the S gene with respect to the Wuhan reference genome (NC_045512.2). Spatio-temporal analysis indicates that the larger cities of Nabeul, Tunis and Kairouan constituted epicenters for the AY.122 sub-lineage and subsequent dispersion to the rest of the country.DiscussionThis study adds more knowledge about the Delta variant and sub-variants distribution worldwide by documenting genomic and epidemiological data from Tunisia, a North African region. Such results may be helpful to the understanding of future COVID-19 waves and variants.