Relevant bibliographies by topics / Astature

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Astature'

Author: Grafiati
Published: 25 May 2024
Last updated: 31 July 2025

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Journal articles on the topic "Astature"

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Li, Yawen, Ming-Kuan Chyan, Donald K. Hamlin, Holly Nguyen, Eva Corey, and D. Scott Wilbur. "Oxidation of p-[125I]Iodobenzoic Acid and p-[211At]Astatobenzoic Acid Derivatives and Evaluation In Vivo." International Journal of Molecular Sciences 23, no. 18 (2022): 10655. http://dx.doi.org/10.3390/ijms231810655.

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The alpha particle-emitting radionuclide astatine-211 (211At) is of interest for targeted radiotherapy; however, low in vivo stability of many 211At-labeled cancer-targeting molecules has limited its potential. As an alternative labeling method, we evaluated whether a specific type of astatinated aryl compound that has the At atom in a higher oxidation state might be stable to in vivo deastatination. In the research effort, para-iodobenzoic acid methyl ester and dPEG4-amino acid methyl ester derivatives were prepared as HPLC standards. The corresponding para-stannylbenzoic acid derivatives wer
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Wilbur, D. "[211At]Astatine-Labeled Compound Stability: Issues with Released [211At]Astatide and Development of Labeling Reagents to Increase Stability." Current Radiopharmaceuticalse 1, no. 3 (2008): 144–76. http://dx.doi.org/10.2174/1874471010801030144.

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Nagao, Y., M. Yamaguchi, S. Watanabe, N. S. Ishioka, N. Kawachi, and H. Watabe. "Performance improvement of Compton imaging of astatine-211 by optimising coincidence time windows." Journal of Instrumentation 16, no. 12 (2021): C12031. http://dx.doi.org/10.1088/1748-0221/16/12/c12031.

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Abstract Astatine-211 is one of the promising radioisotopes for targeted alpha therapy. Optimising treatment strategies as well as determining the suitability of a given agent for a particular patient requires to image the time-dependent distribution of the targeted radiotherapeutic agent both in tumours and in normal tissues. Since the biodistribution of astatine is different from that of iodine, imaging astatine-211 directly is essential. In the previous study of astatine-211 Compton imaging, random coincidence events due to polonium K-shell X-rays were dominant and seemed to cause saturatio
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CORSON, DALE R. "ASTATINE." Chemical & Engineering News 81, no. 36 (2003): 158. http://dx.doi.org/10.1021/cen-v081n036.p158.

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Meyer, Geerd-J. "Astatine." Journal of Labelled Compounds and Radiopharmaceuticals 61, no. 3 (2018): 154–64. http://dx.doi.org/10.1002/jlcr.3573.

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Aneheim, Emma, Tom Bäck, Holger Jensen, Stig Palm, and Sture Lindegren. "A proposed production method for astatinated (At-211) Trastuzumab for use in a Phase I clinical trial." PLOS ONE 19, no. 9 (2024): e0307543. http://dx.doi.org/10.1371/journal.pone.0307543.

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Astatine-211 is a nuclide with a short half-life of 7.2 h, that show promise for targeted alpha therapy of disseminated cancer. Despite nuclide production being straight-forward using a medium energy cyclotron and an uncomplicated target, not many cyclotrons are currently producing the nuclide. In this work we propose a stream-lined method to produce astatine labelled antibodies that enable production of clinical doses at other sites, remote from the nuclide producing cyclotron. Preconjugating the antibody prior to labelling, quick and efficient astatine recovery from the irradiated target in
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Takashima, Hiroki, Shino Manabe, Ryo Tsumura, et al. "Abstract 4344: Broader therapeutic window via combining sodium ascorbate for protecting radioactive antibodies from radiolysis and sodium perchlorate for blocking sodium iodide symporter in radioimmunotherapy with astatine-211." Cancer Research 85, no. 8_Supplement_1 (2025): 4344. https://doi.org/10.1158/1538-7445.am2025-4344.

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Background: Increasing attention has been paid to developing new cancer treatments with alpha particles characterized by a high linear energy transfer (LET) and a range of 50-100 µm in tissue, which is equivalent to 5-10 cells. Due to the short path length, tumor-selective accumulation of alpha particles is pivotal for achieving a reasonable therapeutic window. Previously, we demonstrated that reactive oxygen species (ROS) generated via the radiolysis of water in storage solution denature antibodies labeled with astatine-211, an alpha emitter, which results in disrupted specific binding activi
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Wilbur, D. Scott. "Enigmatic astatine." Nature Chemistry 5, no. 3 (2013): 246. http://dx.doi.org/10.1038/nchem.1580.

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Sarr, Serigne, Julien Pilmé, Gilles Montavon, Jean-Yves Le Questel, and Nicolas Galland. "Astatine Facing Janus: Halogen Bonding vs. Charge-Shift Bonding." Molecules 26, no. 15 (2021): 4568. http://dx.doi.org/10.3390/molecules26154568.

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The nature of halogen-bond interactions was scrutinized from the perspective of astatine, potentially the strongest halogen-bond donor atom. In addition to its remarkable electronic properties (e.g., its higher aromaticity compared to benzene), C6At6 can be involved as a halogen-bond donor and acceptor. Two-component relativistic calculations and quantum chemical topology analyses were performed on C6At6 and its complexes as well as on their iodinated analogues for comparative purposes. The relativistic spin–orbit interaction was used as a tool to disclose the bonding patterns and the mechanis
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Yagishita, Atsushi, Miho Katsuragawa, Shin’ichiro Takeda, et al. "Development and Utility of an Imaging System for Internal Dosimetry of Astatine-211 in Mice." Bioengineering 11, no. 1 (2023): 25. http://dx.doi.org/10.3390/bioengineering11010025.

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In targeted radionuclide therapy, determining the absorbed dose of the ligand distributed to the whole body is vital due to its direct influence on therapeutic and adverse effects. However, many targeted alpha therapy drugs present challenges for in vivo quantitative imaging. To address this issue, we developed a planar imaging system equipped with a cadmium telluride semiconductor detector that offers high energy resolution. This system also comprised a 3D-printed tungsten collimator optimized for high sensitivity to astatine-211, an alpha-emitting radionuclide, and adequate spatial resolutio
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Dissertations / Theses on the topic "Astature"

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Desiree, Patrick R. "Synthèse et développement de macrocycles pour la capture d'anions d'intérêt thérapeutique." Electronic Thesis or Diss., Aix-Marseille, 2022. http://www.theses.fr/2022AIXM0152.

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La chimie supramoléculaire consiste en l’assemblage par des interactions non-covalentes d’architectures moléculaires plus ou moins complexes. A l’état naturel, ces édifices remplissent de nombreuses fonctions telle que le support génétique par la molécule d’ADN. Les anions peuvent aussi être impliqués au niveau radiothérapeutique par le biais de l’iodure. Par opposition, ce même élément peut être associé à certaines catastrophes environnementales (explosion de Fukishima, 2011) voire à certaines pathologies (thyroïdopathie). Face aux problématiques citées, il est donc primordial de développer d
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Liu, Lu. "Exploration de la chimie de l'astate en solution : focalisation sur le diagramme de Pourbaix en milieu non complexant et caractérisation de liaisons halogènes induites par l'astate." Thesis, Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire, 2020. http://www.theses.fr/2020IMTA0205.

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L'astate (At, Z = 85) est un élément halogène rare, tous ses isotopes étant radioactifs. En raison des quantités disponibles limitées, aucun outil spectroscopique n'est applicable pour identifier la nature moléculaire des espèces d'At. En conséquence, la chimie de l'At reste méconnue. L'un de ses isotopes, ²¹¹At, est un candidat potentiel pour le traitement de cancers par thérapie alpha ciblée. Cependant, la connaissance limitée de ses propriétés chimiques a entravé les tentatives de marquage de ²¹¹At avec des molécules porteuses ciblant la maladie. Cela a conduit au développement d’un program
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Fouinneteau, Romain. "Design and evaluation of astatoaryl compounds stabilized against dehalogenation in oxidizing media." Electronic Thesis or Diss., Nantes Université, 2024. http://www.theses.fr/2024NANU1032.

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La thérapie interne vectorisée alpha est une stratégie émergente pour le traitement des cancers. Le radiohalogène astate-211 (t1/2 = 7,2h) est l'un des émetteurs alpha les plus prometteurs. Malgré des applications cliniques initiales encourageantes avec le N- [211At]succinimidylastatobenzoate ([211At]SAB) comme groupe prosthétique pour marquer les anticorps, les études in vivo ont montré que la liaison carbone-astate est insuffisamment stable et conduit à la libération d'astate dans l'organisme, ce qui peut nuire à l'efficacité et à la sécurité du patient. Néanmoins, des études récentes ont mo
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Da, Silva I., T. Sauvage, P. Rifard, F. Durand, J. P. Trasbot, and N. Michel. "Evolution of production of Astatine-211 in Orléans Cyclotron." Helmholtz-Zentrum Dresden - Rossendorf, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-166243.

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Introduction Since 2005, we produce, at academic scale in Orleans, 211At for needs of chemistry and physicians teams of Nantes in research project of alpha immunotherapy. Between 2005 and 2014, several modifications were been made on preparation of target, targetry and radiation to protect personnel. Material and Methods The first target was a molten Bi metal onto a Cu support pre-treated with acid attack. The wished thickness (up to 100 µm) was obtained by mechanical treatment of target. The target is irradiated at 32MeV alpha particle beam for around 2 hours and then delivered by road trans
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Champion, Julie. "Exploration du caractère métallique de l'astate en solution aqueuse." Nantes, 2009. http://www.theses.fr/2009NANT2086.

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L'alpha-radiothérapie est une technique particulièrement innovante de thérapie des cancers, tout en étant complémentaire des thérapies déjà existantes. Elle repose sur l'utilisation d'un vecteur spécifique (anticorps ou peptide) de la cellule cible à détruire,radiomarqué » par un élément radioactif émetteur alpha. L'astate 211 est un candidat particulièrement intéressant compte tenu de l'énergie des particules  qu'il émet et de sa période physique (7,2 h). L'une des voies de marquage envisagée est l'utilisation de l'astate à un degré d'oxydation supérieur à zéro en tant que cation. En effet,
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Guo, Ning. "Investigation of the chemical properties of astatine at +I and –I oxydation states in aqueous solution." Thesis, Nantes, 2017. http://www.theses.fr/2017NANT4038/document.

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La thérapie alpha ciblée est une technique prometteuse pour le traitement de cancers. L’astate-211, de temps de demi-vie de 7,21 h, est considéré comme un candidat prometteur pour cette application. Une condition pré-requise est de fixer de manière stable l’isotope radioactif sur le vecteur qui va servir à reconnaitre les cellules malades. Ceci demande une connaissance approfondie des propriétés chimiques de l’astate. Compte tenu de sa position dans le tableau périodique des éléments, l’astate peut exister sous la forme At− en cohérence avec les propriétés chimiques des autres halogènes, et po
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Guérard, François. "Nouvelle méthode de radiomarquage des anticorps à l'astate-211 hypervalent pour la radioimmunothérapie alpha des cancers." Nantes, 2010. https://archive.bu.univ-nantes.fr/pollux/show/show?id=55d1b24d-6cbb-4198-af40-b3764c525301.

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L'astate-211 est un radionucléide émetteur de particules alpha très prometteur pour la thérapie des cancers. Associé à un vecteur immunologique adapté, il pourrait permettre le traitement de différents types de micrométastases ou de cancers résiduels. Cependant, le manque de stabilité des méthodes de radiomarquage des anticorps avec ce radionucléide est un frein au développement d'applications cliniques. Ces travaux ont eu pour but la mise au point d'une nouvelle méthode de radiomarquage des anticorps à l'astate-211. La spécificité de cette méthode est d’utiliser pour la première fois l'astate
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Lindegren, Sture. "Astatine-211 and iodine conjugates : radiohalogenation and preclinical pharmacokonetics for targeted and pretargeted radioimmunotherapy /." Göteborg : Chalmers Univ. of Technology, 2002. http://www.gbv.de/dms/bs/toc/348722176.pdf.

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Sergentu, Dumitru-Claudiu. "Géométries, electronic structures, and physico-chemical porperties of astatine species : an application of relativistic quantum mechanics." Thesis, Nantes, 2016. http://www.theses.fr/2016NANT4024/document.

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Les tentatives menées pour détruire des cellules cancéreuses avec les agents radiothérapeutiques à base de 211 At qui ont été synthétisés jusqu’à présent ne sont pas encore pleinement satisfaisantes car elles sont entachées par une deastatination in vivo. Étant donné que ce problème est lié aux connaissances actuelles qui sont limitées concernant la chimie de base de l’astate et de ses espèces, des recherches fondamentales combinant des expériences à l’échelle des ultra-traces et des études théoriques ont été lancées. Dans cette thèse, une étude théorique de plusieurs espèces de l’astate est r
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Bourgeois, Mickaël. "Étude de faisabilité de Radio-Immunothérapie alpha à l'astate-211." Nantes, 2009. https://archive.bu.univ-nantes.fr/pollux/show/show?id=451eb856-6a13-4712-9592-273f054a9531.

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La radio-immunothérapie alpha est une thérapie anticancéreuse prometteuse qui consiste à vectoriser des radionucléides émetteurs de particules alpha à l'aide d'agents immunospécifiques de certaines tumeurs afin de les détruire. La première partie de ce travail présente les différentes caractéristiques conditionnant la réussite de la radio-immunothérapie en replaçant cette approche thérapeutique originale dans l'arsenal anti-cancéreux. Au cours de ces dernières années, l'astate-211 est apparu comme l'un des isotopes émetteurs de particules alpha les plus intéressants, l'ensemble des caractérist
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Books on the topic "Astature"

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Berei, Klara, Siegfried H. Eberle, H. W. Kirby, et al. At Astatine. Edited by Hans Karl Kugler and Cornelius Keller. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8.

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Zegeye, Abebe. Mulatu Astatke: The making of Ethio jazz. UNISA Press, 2009.

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Sims, H. E. ²¹¹At and ⁹⁰Y: Two nuclides for potential use in tumour therapy : production at Harwell Laboratory. Chemistry Division, Harwell Laboratory, 1986.

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Kenyon, Michael. Astatine. Brick Books Incorporated, 2014.

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Keller, Cornelius, and Hans K. Kugler. At Astatine. Springer, 2013.

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At Astatine. Springer London, Limited, 2013.

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Halogen Elements: Fluorine, Chlorine, Bromine, Iodine, Astatine. Rosen Publishing Group, 2010.

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Roza, Greg. Halogen Elements Fluorine, Chlorine, Bromine, Iodine, Astatine. Rosen Publishing Group, 2010.

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Zegeye, Abebe. Mulatu Astatke: The Making of Ethio Jazz. Africa World Press, 2022.

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DeCarlo, Raymond A. Linear systems: Astate variable approach with numerical implementation. Prentice-Hall International, 1989.

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Book chapters on the topic "Astature"

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Kirby, H. W. "History." In At Astatine. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_1.

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Eberle, S. H., Klara Berei, and László Vasáros. "Chemical Behavior and Compounds of Astatine." In At Astatine. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_10.

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Kirby, H. W. "Natural Occurrence." In At Astatine. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_2.

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Münzel, H. "Nuclear Properties of Astatine Isotopes." In At Astatine. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_3.

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Kirby, H. W., and K. Rössler. "Production, Isolation, and Purification of Astatine Isotopes." In At Astatine. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_4.

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Vasáros, László, and Klara Berei. "General Properties of Astatine." In At Astatine. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_5.

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Kirby, H. W. "Analytical Chemistry of Astatine." In At Astatine. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_6.

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Rössler, K. "Handling of Astatine." In At Astatine. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_7.

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Seidel, Arnulf. "Astatine in Biology and Nuclear Medicine." In At Astatine. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_8.

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Rössler, Kurt. "Irradiation and Self-Irradiation of Astatine Compounds." In At Astatine. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_9.

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Conference papers on the topic "Astature"

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"ASTATINE-211 AS AN EMERGING RADIOISOTOPE FOR TARGETED ALPHA THERAPY (TAT)." In RAD Conference. RAD Centre, Niš, Serbia, 2024. https://doi.org/10.21175/radproc.2024.11.

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Cancer treatment presents complex challenges, necessitating the exploration of innovative approaches for diagnosis and therapy. Among emerging prospects, Radiopharmaceutical Therapy (RPT) using α- emitting radionuclides has gained notable attention. This article provides an overview of the literature on Targeted Alpha Therapy (TAT), explicitly focusing on astatine-211 (211At). It discusses methodologies for labeling 211At, along with the associated challenges, to contribute to a deeper understanding of its potential role in TAT. The physical properties of 211At make it a promising candidate fo
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Jakobsson, U., J. Uusitalo, K. Auranen, et al. "Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei." In Nuclear Structure and Dynamics ’15. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4932258.

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Takashima, Hiroki, Yoshikatsu Koga, Kazunobu Onuki, et al. "Abstract 2863: Preclinical evaluation of astatine-211-conjugated anti-tissue factor antibody." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2863.

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Uusitalo, J., U. Jakobsson, and Bertram Blank. "Delayed and In-beam Spectroscopy on Francium and Astatine Nuclei at the Proton Drip Line." In THE 4TH INTERNATIONAL CONFERENCE ON PROTON EMITTING NUCLEI AND RELATED TOPICS. AIP, 2011. http://dx.doi.org/10.1063/1.3664144.

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Takai, Toshihide, Tomohiro Furukawa, Shigeki Watanabe, and Noriko S. Ishioka. "Corrosion Behavior of Iron-Chrome Alloys in Liquid Bismuth." In 2021 28th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/icone28-63277.

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Abstract For the mass production of astatine-211, a promising radiopharmaceutical for cancer treatment, the National Institute for Quantum and Radiological Science and Technology has proposed the innovative “Liquid Bismuth Target System.” The target window in this system must be made from a material that resists the highly corrosive liquid bismuth environment. To meet this requirement, a promising target window material was selected in corrosion experiments performed in stagnant liquid bismuth. Based on knowledge of corrosion in liquid lead–bismuth eutectic gained during the development of fas
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Reports on the topic "Astature"

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Ruth, T. J., M. Dombsky, J. M. D'Auria, and T. E. Ward. Radiochemistry of astatine. Office of Scientific and Technical Information (OSTI), 1988. http://dx.doi.org/10.2172/6748269.

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Wilbur, Daniel. Automated Isolation of Astatine-211 and Chemistry Evaluation. Office of Scientific and Technical Information (OSTI), 2020. http://dx.doi.org/10.2172/1651207.

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Mach, Robert, Hsiaoju Lee, Mehran Makvandi, et al. Production of Astatine-211 for Translational Science in Radiotherapy. Office of Scientific and Technical Information (OSTI), 2024. http://dx.doi.org/10.2172/2329303.

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Wilbur, D. S. Pretargeting of Astatine-211 for Therapy of Metastic Prostate Cancer. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada374830.

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Lapi, Suzanne E. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), 2019. http://dx.doi.org/10.2172/1575920.

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Ellison, Paul, Jonathan Engle, Aeli Olson, et al. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), 2020. http://dx.doi.org/10.2172/1682261.

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Mach, Robert. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), 2020. http://dx.doi.org/10.2172/1839290.

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Wilbur, Daniel Scott. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators". Office of Scientific and Technical Information (OSTI), 2012. http://dx.doi.org/10.2172/1124492.

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MICHAEL R. ZALUTSKY. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS. Office of Scientific and Technical Information (OSTI), 2012. http://dx.doi.org/10.2172/1047758.

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Zalutsky, Michael. Production of Astatine-211 at the Duke University Medical Center for its regional distribution. Office of Scientific and Technical Information (OSTI), 2016. http://dx.doi.org/10.2172/1233560.

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