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Journal articles on the topic 'Astaxanthin'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Nishida, Yasuhiro, Allah Nawaz, Karen Hecht, and Kazuyuki Tobe. "Astaxanthin as a Novel Mitochondrial Regulator: A New Aspect of Carotenoids, beyond Antioxidants." Nutrients 14, no. 1 (2021): 107. http://dx.doi.org/10.3390/nu14010107.

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Astaxanthin is a member of the carotenoid family that is found abundantly in marine organisms, and has been gaining attention in recent years due to its varied biological/physiological activities. It has been reported that astaxanthin functions both as a pigment, and as an antioxidant with superior free radical quenching capacity. We recently reported that astaxanthin modulated mitochondrial functions by a novel mechanism independent of its antioxidant function. In this paper, we review astaxanthin’s well-known antioxidant activity, and expand on astaxanthin’s lesser-known molecular targets, a

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2

Mularczyk, Malwina, Nabila Bourebaba, Krzysztof Marycz, and Lynda Bourebaba. "Astaxanthin Carotenoid Modulates Oxidative Stress in Adipose-Derived Stromal Cells Isolated from Equine Metabolic Syndrome Affected Horses by Targeting Mitochondrial Biogenesis." Biomolecules 12, no. 8 (2022): 1039. http://dx.doi.org/10.3390/biom12081039.

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Astaxanthin is gaining recognition as a natural bioactive component. This study aimed to test whether astaxanthin could protect adipose-derived stromal stem cells (ASCs) from apoptosis, mitochondrial dysfunction and oxidative stress. Phaffia rhodozyma was used to extract astaxanthin, whose biocompatibility was tested after 24, 48 and 72 h of incubation with the cells; no harmful impact was found. ASCs were treated with optimal concentrations of astaxanthin. Several parameters were examined: cell viability, apoptosis, reactive oxygen levels, mitochondrial dynamics and metabolism, superoxide dis

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3

Lee, Seongheon, Sung Kuk Son, Eunye Cho, Sungah Yoo, Eun-A. Jang, and Sang Hyun Kwak. "Protective Role of Astaxanthin in Regulating Lipopolysaccharide-Induced Inflammation and Apoptosis in Human Neutrophils." Current Issues in Molecular Biology 46, no. 8 (2024): 8567–75. http://dx.doi.org/10.3390/cimb46080504.

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Astaxanthin, a keto-carotenoid, is known to have potent antioxidant properties. This study aims to investigate the anti-inflammatory effect of astaxanthin and its mechanism in human neutrophils. The effects of astaxanthin on lipopolysaccharide (LPS)-stimulated human neutrophils were investigated in vitro. Neutrophils were isolated from healthy volunteers and stimulated with LPS in the presence and absence of astaxanthin. We assessed cytokine production, signaling pathway activation via mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-κB), and apoptosis. Astaxanthin’s im

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4

Turujman, Saleh A., Wayne G. Wamer, Rong Rong Wei, and Richard H. Albert. "Rapid Liquid Chromatographic Method to Distinguish Wild Salmon from Aquacultured Salmon Fed Synthetic Astaxanthin." Journal of AOAC INTERNATIONAL 80, no. 3 (1997): 622–32. http://dx.doi.org/10.1093/jaoac/80.3.622.

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Abstract Analytical methods are needed to determine the presence of color additives in fish. We report a liquid chromatographic (LC) method developed to identify the synthetic form of the color additive astaxanthin in salmon, based on differences in the relative ratios of the configurational isomers of astaxanthin. The distributions of configurational isomers of astaxanthin in the flesh of wild Atlantic and wild Pacific salmon are similar, but significantly different from that in aquacultured salmon. Astaxanthin is extracted from the flesh of salmon, passed through a silica gel Sep-Pak cartrid

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5

Shastak, Yauheni, and Wolf Pelletier. "Captivating Colors, Crucial Roles: Astaxanthin’s Antioxidant Impact on Fish Oxidative Stress and Reproductive Performance." Animals 13, no. 21 (2023): 3357. http://dx.doi.org/10.3390/ani13213357.

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Fish, constantly exposed to environmental stressors due to their aquatic habitat and high metabolic rates, are susceptible to oxidative stress. This review examines the interplay between oxidative stress and fish reproduction, emphasizing the potent antioxidant properties of astaxanthin. Our primary objective is to highlight astaxanthin’s role in mitigating oxidative stress during critical reproductive stages, leading to improved gamete quality, ovary development, and hormone levels. We also explore its practical applications in aquaculture, including enhanced pigmentation and overall fish hea

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6

Panagiotakopoulos, Ioannis, and Constantina Nasopoulou. "Extraction Methods, Encapsulation Techniques, and Health Benefits of Astaxanthin." Sustainability 16, no. 24 (2024): 10859. https://doi.org/10.3390/su162410859.

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Astaxanthin, a red carotenoid pigment found in marine species like microalgae, shrimp, and salmon, is a powerful bioactive molecule with several health effects. Astaxanthin, despite its potential, is highly vulnerable to degradation from external elements, including light, oxygen, and temperature, requiring meticulous extraction and stabilization methods. Astaxanthin can be extracted using solvent extraction, ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), supercritical fluid extraction (SFE), and enzymatic extraction. Additionally, encapsulation methods that improve

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7

Rodriguez-Ruiz, Violeta, José Salatti-Dorado, Abolfazl Barzegari, et al. "Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity." Molecules 23, no. 10 (2018): 2601. http://dx.doi.org/10.3390/molecules23102601.

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Astaxanthin is a xanthophyll carotenoid showing efficient scavenging ability and represents an interesting candidate in the development of new therapies for preventing and treating oxidative stress-related pathologies. However, its high lipophilicity and thermolability often limits its antioxidant efficacy in human applications. Here, we developed a formulation of lipid carriers to protect astaxanthin’s antioxidant activity. The synthesis of natural astaxanthin-loaded nanostructured lipid carriers using a green process with sunflower oil as liquid lipid is presented. Their antioxidant activity

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8

Šimat, Vida, Nikheel Bhojraj Rathod, Martina Čagalj, Imen Hamed, and Ivana Generalić Mekinić. "Astaxanthin from Crustaceans and Their Byproducts: A Bioactive Metabolite Candidate for Therapeutic Application." Marine Drugs 20, no. 3 (2022): 206. http://dx.doi.org/10.3390/md20030206.

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In recent years, the food, pharma, and cosmetic industries have shown considerable interest in bioactive molecules of marine origin that show high potential for application as nutraceuticals and therapeutic agents. Astaxanthin, a lipid-soluble and orange-reddish-colored carotenoid pigment, is one of the most investigated pigments. Natural astaxanthin is mainly produced from microalgae, and it shows much stronger antioxidant properties than its synthetic counterpart. This paper aims to summarize and discuss the important aspects and recent findings associated with the possible use of crustacean

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Zulkarnain, Muhammad Iskandar, Hermin Pancasakti Kusumaningrum, Nurhayati Nurhayati, Agung Suprihadi, and Muhammad Zainuri. "Identifikasi Molekuler Chlorella sorokiniana menggunakan Marka ITS dan 18S rDNA serta Produksi Karotenoid dengan Perlakuan Cahaya." Buletin Oseanografi Marina 12, no. 2 (2023): 153–63. http://dx.doi.org/10.14710/buloma.v12i2.46705.

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Chlorella sorokiniana merupakan salah satu mikroalga penghasil astaxantin. Produksi astaxantin C. sorokiniana dapat meningkat pada kondisi kultur yang optimal. Penelitian ini bertujuan untuk memastikan identitas C. sorokiniana secara molekuler menggunakan ITS, dan 18S rDNA, serta untuk mengetahui pertumbuhan dan produksi astaxantin C. sorokiniana berdasarkan perlakuan cahaya. Metode yang digunakan pada penelitian ini meliputi kultivasi mikroalga C. sorokiniana, isolasi DNA, uji kuantitatif DNA, identifikasi molekuler melalui proses amplifikasi DNA dengan PCR (Polymerase Chain Reaction) menggun

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10

Sabir, Sidra, AHM Mahmudur Rahman, and Abdul Haseeb Bhutta. "Astaxanthin as a potential therapeutic agent for knee osteoarthritis: A review of mechanisms and clinical evidence." Bangabandhu Sheikh Mujib Medical University Journal 18, no. 1 (2025): e76227. https://doi.org/10.3329/bsmmuj.v18i1.76227.

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Bakground: Knee osteoarthritis (KOA) poses an important challenge in musculoskeletal healthcare, prompting the need for innovative therapeutic strategies. Astaxanthin, a potent antioxidant carotenoid, has gained interest due to its multifaceted mechanisms of action and potential role in KOA management. This review aims to examine the therapeutic mechanisms of astaxanthin in KOA, alongside clinical evidence supporting its effectiveness through a narrative synthesis of preclinical and clinical studies. Methods: A comprehensive review of the literature was conducted across Web of Science, Pubmed,

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Laja, Rana Salsabila Putri. "Astaxanthin untuk Kesehatan Kardiovaskular." Jurnal Penelitian Perawat Profesional 3, no. 2 (2021): 243–52. http://dx.doi.org/10.37287/jppp.v3i2.259.

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Penyakit kardiovaskular adalah penyebab utama kematian di seluruh dunia. Adanya dislipidemia, gangguan toleransi glukosa, dan hipertensi dengan akumulasi lemak visceral yang disebut sindrom metabolik, meningkatkan risiko penyakit kardiovaskular. Sindrom metabolik sering ditandai dengan stres oksidatif, gangguan keseimbangan antara produksi reactive oxygen species dan pertahanan antioksidan. Sementara itu, astaxanthine diketahui memiliki karakteristik antioksidan yang kuat, yang telah dilaporkan melampaui karakteristik β-karoten atau bahkan α-tokoferol. Penelitian ini merupakan literature revie

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12

Aribisala, Jamiu Olaseni, Sonto Nkosi, Kehinde Idowu, et al. "Astaxanthin-Mediated Bacterial Lethality: Evidence from Oxidative Stress Contribution and Molecular Dynamics Simulation." Oxidative Medicine and Cellular Longevity 2021 (December 9, 2021): 1–24. http://dx.doi.org/10.1155/2021/7159652.

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The involvement of cellular oxidative stress in antibacterial therapy has remained a topical issue over the years. In this study, the contribution of oxidative stress to astaxanthin-mediated bacterial lethality was evaluated in silico and in vitro. For the in vitro analysis, the minimum inhibitory concentration (MIC) of astaxanthin was lower than that of novobiocin against Staphylococcus aureus but generally higher than those of the reference antibiotics against other test organisms. The level of superoxide anion of the tested organisms increased significantly following treatment with astaxant

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13

Toyoshima, Hiroki, Ami Miyata, Risako Yoshida, Taichiro Ishige, Shinichi Takaichi, and Shinji Kawasaki. "Distribution of the Water-Soluble Astaxanthin Binding Carotenoprotein (AstaP) in Scenedesmaceae." Marine Drugs 19, no. 6 (2021): 349. http://dx.doi.org/10.3390/md19060349.

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Photooxidative stress-inducible water-soluble astaxanthin-binding proteins, designated as AstaP, were identified in two Scenedesmaceae strains, Coelastrella astaxanthina Ki-4 and Scenedesmus obtusus Oki-4N; both strains were isolated under high light conditions. These AstaPs are classified as a novel family of carotenoprotein and are useful for providing valuable astaxanthin in water-soluble form; however, the distribution of AstaP orthologs in other microalgae remains unknown. Here, we examined the distribution of AstaP orthologs in the family Scenedesmaceae with two model microalgae, Chlamyd

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14

Pan, Li, Hongyan Wang, and Keren Gu. "Nanoliposomes as Vehicles for Astaxanthin: Characterization, In Vitro Release Evaluation and Structure." Molecules 23, no. 11 (2018): 2822. http://dx.doi.org/10.3390/molecules23112822.

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Astaxanthin was encapsulated in nanoliposomes by a film dispersion-ultrasonic technique using soybean phosphatidyl choline. The astaxanthin-loaded nanoliposomes displayed advantages in the aspects of high encapsulation efficiency and less particle size with a remarkably homodisperse size distribution. Based on X-ray diffraction and differential scanning calorimetry the analysis, it has been demonstrated that there could be interactions of astaxanthin with the lipid bilayer, resulting in the forming of astaxanthin-loaded nanoliposomes. The thermal gravimetric analysis revealed that the thermal

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15

Cui, Suzhen, Yun Li, Le Liu, Qianhong Wang, and Feizhou Chen. "Changes in astaxanthin and fatty acid concentrations during the developmental process in the calanoid Arctodiaptomus walterianus in an alpine lake at low latitudes." Journal of Plankton Research 43, no. 2 (2021): 314–24. http://dx.doi.org/10.1093/plankt/fbab019.

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Abstract Astaxanthin is ubiquitous in calanoid copepods in high latitude or altitude regions and is well studied. However, the dynamics of astaxanthin in calanoids at low latitudes are less studied. We collected samples during the ice-free season from Lake Mubanghai, an alpine lake located in a low-latitude and high-altitude region, and analyzed astaxanthin content changes among different developmental stages in Arctodiaptomus walterianus. The total astaxanthin content in A. walterianus varied from 1.66 to 4.49 μg/mg dry weight and was highest in October, the month with the lowest temperature

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16

Li, Bowen, Chunxiu Chen, Xiaoqing Zhou, et al. "Effectiveness of Astaxanthin as a Feed Supplement to Improve Growth Performance and Feed Utilization in Aquaculture Animals: A Meta-Analysis." Antioxidants 14, no. 5 (2025): 609. https://doi.org/10.3390/antiox14050609.

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Aquaculture, a vital component of global food supply, faces challenges from environmental stressors that compromise aquatic animal health and productivity. Astaxanthin, a potent carotenoid antioxidant, has shown promise in enhancing growth and stress resilience in aquaculture species, yet its effects remain inconsistent across studies. This meta-analysis systematically evaluates the efficacy of dietary astaxanthin supplementation on growth, feed utilization, antioxidant capacity, and immune function in aquaculture animals. Following Preferred Reporting Items for Systematic Reviews and Meta-Ana

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17

BAUMANN, LESLIE S. "Astaxanthin." Skin & Allergy News 43, no. 3 (2012): 23. http://dx.doi.org/10.1016/s0037-6337(12)70100-6.

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18

Kindlund, Petra J. "Astaxanthin." Nutrafoods 10, no. 1 (2011): 27–31. http://dx.doi.org/10.1007/bf03223352.

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Kindlund, Petra J. "Astaxanthin." Nutrafoods 10, no. 2-3 (2011): 49–53. http://dx.doi.org/10.1007/bf03223388.

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20

Mohammed, Yousef, Ding Ye, Mudan He, Houpeng Wang, Zuoyan Zhu, and Yonghua Sun. "Production of Astaxanthin by Animal Cells via Introduction of an Entire Astaxanthin Biosynthetic Pathway." Bioengineering 10, no. 9 (2023): 1073. http://dx.doi.org/10.3390/bioengineering10091073.

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Astaxanthin is a fascinating molecule with powerful antioxidant activity, synthesized exclusively by specific microorganisms and higher plants. To expand astaxanthin production, numerous studies have employed metabolic engineering to introduce and optimize astaxanthin biosynthetic pathways in microorganisms and plant hosts. Here, we report the metabolic engineering of animal cells in vitro to biosynthesize astaxanthin. This was accomplished through a two-step study to introduce the entire astaxanthin pathway into human embryonic kidney cells (HEK293T). First, we introduced the astaxanthin bios

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21

Mauludia, Mauludia, Thamrin Usman, Winda Rahmalia, Dwi Imam Prayitno, and Siti Nani Nurbaeti. "Ekstraksi, Karakterisasi dan Uji Aktivitas Antioksidan Astaxanthin dari Produk Fermentasi Udang (Cincalok)." Jurnal Kelautan Tropis 24, no. 3 (2021): 311–22. http://dx.doi.org/10.14710/jkt.v24i3.10497.

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Shrimp is one of the aquatic organisms that contain several active compounds, including astaxanthin. Cincalok is one of the fermented shrimp products containing astaxanthin. This study aims to determine the characteristics of astaxanthin extract from cincalok and its antioxidant activity. Extraction of astaxanthin from cincalok was carried out using the reflux method with acetone : cyclohexane (20:80 v/v) as a solvent. The identification and characterization of astaxanthin was carried out using thin-layer chromatography (TLC), UV-Vis spectrophotometry, and High-Pressure Liquid Chromatography (

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22

Nanda, Elsa Vera, Erdawati, Yussi Pratiwi, and Eriska Rahmi Putri. "Characteristic and Photostability of Astaxanthin Extract from Shrimp Shells by Microwave Assisted Extraction Using Nades Solvent." Journal of Physics: Conference Series 2309, no. 1 (2022): 012036. http://dx.doi.org/10.1088/1742-6596/2309/1/012036.

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Abstract This study aims to determine the effect of temperature and light UV on the colour photostability of astaxanthin microcapsule. Astaxanthin from shrimp shells, extracts by microwave assisted extraction using NADES as the solvent. The optimal conditions obtained were, a microwave power of 180 W, an extraction time of 5 minutes, and ratio NADES shrimp shell powder 8: 1 mL/g with yield astaxanthin of 7,466 ppm. Astaxanthin is purified using petroleum ether and dehydrated with anhydrous natrium sulphite. The purification results showed an increase in the brightness of the astaxanthin colour

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Kubo, Hiroaki, Kazuhisa Asai, Kazuya Kojima, et al. "Astaxanthin Suppresses Cigarette Smoke-Induced Emphysema through Nrf2 Activation in Mice." Marine Drugs 17, no. 12 (2019): 673. http://dx.doi.org/10.3390/md17120673.

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Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). The activation of nuclear factor erythroid 2-related factor 2 (Nrf2) is a key cellular defense mechanism against oxidative stress. Recent studies have shown that astaxanthin protects against oxidative stress via Nrf2. In this study, we investigated the emphysema suppression effect of astaxanthin via Nrf2 in mice. Mice were divided into four groups: control, smoking, astaxanthin, and astaxanthin + smoking. The mice in the smoking and astaxanthin + smoking groups were exposed to cigarett

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Apriliani, Seka Indah, Ali Djunaedi, and Chrisna Adhi Suryono. "Manfaat Astaxanthin pada Pakan terhadap Warna Ikan Badut Amphiprion percula, Lacepède, 1802 (Actinopterygii: Pomacentridae)." Journal of Marine Research 10, no. 4 (2021): 551–59. http://dx.doi.org/10.14710/jmr.v10i4.31987.

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Ikan Badut Amphiprion percula merupakan ikan hias laut yang mulai dibudidayakan oleh pemerintah pada tahun 2009 yang memiliki keunggulan pada corak warna yang unik dan kelangsungan hidup yang tinggi. Warna tubuh ikan A. percula dapat pudar disebabkan oleh beberapa faktor, diantaranya: umur, gen, penyakit, dan pencahayaan. Salah satu cara meningkatkan warna Ikan A. percula adalah dengan pemberian tepung Astaxanthin yang diperoleh secara komersial, dengan komposisi astaxanthin dari limbah kepala udang. Tujuan penelitian ini adalah untuk mengetahui perubahan warna dan pertumbuhan Ikan A. percula

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25

Koopmann, Inga K., Annemarie Kramer, and Antje Labes. "Development and validation of reliable astaxanthin quantification from natural sources." PLOS ONE 17, no. 12 (2022): e0278504. http://dx.doi.org/10.1371/journal.pone.0278504.

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Astaxanthin derived from natural sources occurs in the form of various esters and stereomers, which complicates its quantitative and qualitative analysis. To simplify and standardize astaxanthin measurement with high precision, an enzymolysis-based astaxanthin quantification method was developed to hydrolyze astaxanthin esters and determine free astaxanthin in all its diastereomeric forms. Astaxanthin standards and differently processed Haematococcus pluvialis biomass were investigated. Linear correlation of standards of all-E-astaxanthin was observed in a measurement range between extract con

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AL-Tarifi, Bayan Yousef, Azizah Mahmood, Suvik Assaw, and Hassan I. Sheikh. "Application of Astaxanthin and its Lipid Stability in Bakery Product." Current Research in Nutrition and Food Science Journal 8, no. 3 (2020): 962–74. http://dx.doi.org/10.12944/crnfsj.8.3.24.

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The application of astaxanthin is not widely studied especially on its uses and relationship toward lipid stability in food products. Therefore, this study was aimed to determine the antioxidant activity of astaxanthin and evaluate its lipid stability, physicochemical and sensory properties of astaxanthin formulated cookies. The antioxidant activity of astaxanthin was analyzed using DPPH, HRSA and FRAP assays. Meanwhile, lipid stability including peroxide value (PV), p-anisidine value (P-aV) and TOTOX value was evaluated periodically on the formulated cookies (10%, 15% and 20% of astaxanthin).

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Panagiotakopoulos, Ioannis, Haralabos C. Karantonis, Ioannis Geraris Kartelias, and Constantina Nasopoulou. "Ultrasonic-Assisted Extraction of Astaxanthin from Shrimp By-Products Using Vegetable Oils." Marine Drugs 21, no. 9 (2023): 467. http://dx.doi.org/10.3390/md21090467.

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Background: The use of conventional astaxanthin extraction methods, typically involving organic solvents, leads to a heightened environmental impact. The aim of this study was to explore the potential use of environmentally friendly extraction solvents, such as vegetable oils, for recovering the shrimp by-product astaxanthin. Methods: Ultrasound-assisted extraction (UAE) in vegetable oils, including olive oil (OO), sunflower oil (SO), and flaxseed oil (FO), was employed to extract astaxanthin. The astaxanthin antioxidant activity was evaluated using an ABTS assay, and a mixture of gum Arabic a

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Zhang, Zhong-Wei, Xiao-Chao Xu, Ting Liu, and Shu Yuan. "Mitochondrion-Permeable Antioxidants to Treat ROS-Burst-Mediated Acute Diseases." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/6859523.

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Reactive oxygen species (ROS) play a crucial role in the inflammatory response and cytokine outbreak, such as during virus infections, diabetes, cancer, cardiovascular diseases, and neurodegenerative diseases. Therefore, antioxidant is an important medicine to ROS-related diseases. For example, ascorbic acid (vitamin C, VC) was suggested as the candidate antioxidant to treat multiple diseases. However, long-term use of high-dose VC causes many side effects. In this review, we compare and analyze all kinds of mitochondrion-permeable antioxidants, including edaravone, idebenone,α-Lipoic acid, ca

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Choi, Hye Duck, Hee Eun Kang, Si Hyung Yang, Myung Gull Lee, and Wan Gyoon Shin. "Pharmacokinetics and first-pass metabolism of astaxanthin in rats." British Journal of Nutrition 105, no. 2 (2010): 220–27. http://dx.doi.org/10.1017/s0007114510003454.

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Astaxanthin is a carotenoid with antioxidant, anti-cancer and anti-inflammatory properties. The pharmacokinetics of astaxanthin after its intravenous (5, 10, and 20 mg/kg) and oral (100 and 200 mg/kg) administration and its first-pass extraction ratios after its intravenous, intraportal or intragastric (20 mg/kg) administration were evaluated in rats. The pharmacokinetic parameters of astaxanthin were dose dependent after its intravenous administration, due to the saturable hepatic metabolism of astaxanthin, but dose independent after oral administration. The gastrointestinal absorption of ast

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Thamin, Aswan, Chairulwan Umar, and Darussadah Paransa. "Analisis Pigmen dan Aktivitas Antibakteri In Vitro Pigmen Astaksantin Kepiting (Grapsus albolineatus Lamarck) Jantan." Jurnal Perikanan Universitas Gadjah Mada 8, no. 2 (2006): 160. http://dx.doi.org/10.22146/jfs.133.

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Grapsus albolineatus is one of marine crustaceans which have carotenoid (astaxanthin) pigment. This research was conducted to analyze carotenoids (astaxanthin) extracted from G. albolineatus, and evaluate their in vitro antibacterial activity. The research was done in March-July 2002. Samples were collected from Manado Gulf, North Sulawesi. The result indicated that the carapace contained 4 carotenoids namely ß-caroten, ecinenon, astaxanthin diester, and astaxanthin monoester. In addition, the epidermis contained free astaxanthin. In vitro antibacterial activity test indicated that astaxanthin

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Sratongfaeng, Chuenjai, Nithipun Suksumek, Nithikoon Aksorn, Pithi Chanvorachote, and Kulwara Meksawan. "Astaxanthin Supplementation Lowers Dietary Intake in Healthy Subjects." Current Topics in Nutraceutical Research 19, no. 1 (2020): 46–51. http://dx.doi.org/10.37290/ctnr2641-452x.19:46-51.

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Astaxanthin, a potent antioxidant compound, is well recognized for its beneficial effects to protect from oxidative stress and free radicals. However, the effects of long period of use of astaxanthin on biological parameters, health indicators, and energy intake are still largely unknown. A total of 33 healthy participants aged 21–54 years with body mass index in the range of 18.50−24.90 kg/m<sup>2</sup> were enrolled in this randomized controlled trial and were assigned into astaxanthin and placebo groups. The participants in the astaxanthin group received 4 mg of astaxanthin once daily for 1

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Nakagawa, Kiyotaka, Takehiro Kiko, Taiki Miyazawa, et al. "Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes." British Journal of Nutrition 105, no. 11 (2011): 1563–71. http://dx.doi.org/10.1017/s0007114510005398.

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Phospholipid hydroperoxides (PLOOH) accumulate abnormally in the erythrocytes of dementia patients, and dietary xanthophylls (polar carotenoids such as astaxanthin) are hypothesised to prevent the accumulation. In the present study, we conducted a randomised, double-blind, placebo-controlled human trial to assess the efficacy of 12-week astaxanthin supplementation (6 or 12 mg/d) on both astaxanthin and PLOOH levels in the erythrocytes of thirty middle-aged and senior subjects. After 12 weeks of treatment, erythrocyte astaxanthin concentrations were higher in both the 6 and 12 mg astaxanthin gr

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Cong, Xin-Yuan, and Hui-Zhen Zhang. "Recent Progress in Sources, Biological Activity and Application of Astaxanthin." International Journal of Sciences Volume 8, no. 2019-03 (2019): 31–34. https://doi.org/10.5281/zenodo.3350639.

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Astaxanthin is a powerful biological antioxidant that exists in many living organisms. Various biological activities of astaxanthin confirmed in experimental animals studies. Astaxanthin has enormous potential and promising applications in food and medicine industry. In this paper, the sources,biological function,application of astaxanthin were reviewed.The current review has helpful for the further study on astaxanthin and its applications.Read Complete Article at ijSciences: V82019032011 AND DOI: http://dx.doi.org/10.18483/ijSci.2011

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Shen, Xue, Tianqi Fang, Jian Zheng, and Mingruo Guo. "Physicochemical Properties and Cellular Uptake of Astaxanthin-Loaded Emulsions." Molecules 24, no. 4 (2019): 727. http://dx.doi.org/10.3390/molecules24040727.

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Astaxanthin, a natural pigment carotenoid, is well known for its potential benefits to human health. However, its applications in the food industry are limited, due to its poor water-solubility and chemical instability. Six different emulsifiers were used to prepare astaxanthin-loaded emulsions, including whey protein isolate (WPI), polymerized whey protein (PWP), WPI-lecithin, PWP-lecithin, lecithin, and Tween20. The droplet size, zeta potential, storage stability, cytotoxicity, and astaxanthin uptake by Caco-2 cells were all investigated. The results showed that the droplet size of the emuls

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Cong, X., X. Zang, M. Dong, et al. "Accumulation of phytoene and astaxanthin and related genes expression in Haematococcus pluvialis under sodium acetate stress." Aquatic Biology 29 (November 19, 2020): 155–64. http://dx.doi.org/10.3354/ab00733.

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Phytoene and astaxanthin are 2 important carotenoids in the green alga Haematococcus pluvialis. Under environmental stress, the synthesis of phytoene in H. pluvialis increases significantly, and phytoene is converted to astaxanthin through enzymatic catalysis. This paper analyzes the relationship between astaxanthin and phytoene accumulation in carotenoid synthesis pathways under different concentrations of sodium acetate (NaAc) by high-performance liquid chromatography. The highest concentrations of phytoene and astaxanthin were observed at the NaAc concentration of 6 g l-1 on the 12th day of

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Ikarashi, Nobutomo, Risako Kon, Chika Nagoya, et al. "Effect of Astaxanthin on the Expression and Activity of Aquaporin-3 in Skin in an In-Vitro Study." Life 10, no. 9 (2020): 193. http://dx.doi.org/10.3390/life10090193.

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Astaxanthin (3,3′-dihydroxy-β,β-carotene-4,4′-dione) is a red lipophilic pigment with strong antioxidant action. Oral or topical administration of astaxanthin has been reported to improve skin function, including increasing skin moisture. In this study, we examined the mechanism by which astaxanthin improves skin function by focusing on the water channel aquaporin-3 (AQP3), which plays important roles in maintaining skin moisture and function. When astaxanthin was added to PHK16-0b or HaCaT cells, the mRNA expression level of AQP3 increased significantly in a concentration-dependent manner in

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Karppi, Rissanen, Nyyssönen, et al. "Effects of Astaxanthin Supplementation on Lipid Peroxidation." International Journal for Vitamin and Nutrition Research 77, no. 1 (2007): 3–11. http://dx.doi.org/10.1024/0300-9831.77.1.3.

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Astaxanthin, the main carotenoid pigment in aquatic animals, has greater antioxidant activity in vitro (protecting against lipid peroxidation) and a more polar configuration than other carotenoids. We investigated the effect of three-month astaxanthin supplementation on lipid peroxidation in healthy non-smoking Finnish men, aged 19–33 years by using a randomized double-blind study design. Also absorption of astaxanthin from capsules into bloodstream and its safety were evaluated. The intervention group received two 4-mg astaxanthin (Astaxin®) capsules daily, and the control group two identical

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De Aguiar Saldanha Pinheiro, Ana Cristina, Francisco J. Martí-Quijal, Francisco J. Barba, et al. "Pulsed Electric Fields (PEF) and Accelerated Solvent Extraction (ASE) for Valorization of Red (Aristeus antennatus) and Camarote (Melicertus kerathurus) Shrimp Side Streams: Antioxidant and HPLC Evaluation of the Carotenoid Astaxanthin Recovery." Antioxidants 12, no. 2 (2023): 406. http://dx.doi.org/10.3390/antiox12020406.

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Shrimp side streams represent an important natural source of astaxanthin. Optimization of the astaxanthin extraction process from shrimp side streams is of great importance for the valorization of crustacean side streams and the development of astaxanthin-related products. The combined and independent effects of two innovative extraction technologies (pulsed electric fields (PEFs) and accelerated solvent extraction (ASE)) alone and/or combined in a sequential step, using two different solvents on astaxanthin extraction from two shrimp species, were evaluated. Astaxanthin content in the extract

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Samuel, Sabrina Yeo, Hui-Min David Wang, Meng-Yuan Huang, et al. "Safety Assessment of 3S, 3’S Astaxanthin Derived from Metabolically Engineered K. marxianus." Antioxidants 11, no. 11 (2022): 2288. http://dx.doi.org/10.3390/antiox11112288.

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Previous reviews have already explored the safety and bioavailability of astaxanthin, as well as its beneficial effects on human body. The great commercial potential in a variety of industries, such as the pharmaceutical and health supplement industries, has led to a skyrocketing demand for natural astaxanthin. In this study, we have successfully optimized the astaxanthin yield up to 12.8 mg/g DCW in a probiotic yeast and purity to 97%. We also verified that it is the desired free-form 3S, 3’S configurational stereoisomer by NMR and FITR that can significantly increase the bioavailability of a

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Kingkaew, Engkarat, Nisachon Tedsree, Sukanya Phuengjayaem, et al. "Genomic Insight and Optimization of Astaxanthin Production from a New Rhodotorula sp. CP72-2." Fermentation 9, no. 6 (2023): 501. http://dx.doi.org/10.3390/fermentation9060501.

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Astaxanthin is a carotenoid pigment extensively used in various industries. Rhodotorula sp. CP72-2, isolated from Calotropis gigantea, showed potential astaxanthin production. In this study, strain CP72-2 was identified as a putative new species in the genus Rhodotorula based on the 26S rRNA gene sequence (98% identity). It was first used as the microbial source for producing astaxanthin. Strain CP72-2 was screened for its astaxanthin production and was identified and quantified by High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), and UV-Vis spectr

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Yanyium, Niracha, Wanida Sukketsiri, Pennapa Chonpathompikunlert, et al. "Evaluation of Encapsulated Astaxanthin from White Shrimp Shells (Litopenaeus vannamei) on Hepatotoxicity." Sains Malaysiana 53, no. 2 (2024): 239–48. http://dx.doi.org/10.17576/jsm-2024-5302-01.

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Recent advances in astaxanthin encapsulation have been reported, but hepatotoxic effect remains unclear. The present investigation therefore aimed to examine the effects of encapsulated astaxanthin from white shrimp shells (Litopenaeus vannamei) on liver toxicity. Wistar rats were divided into 6 groups as control (C), and receiving vitamin E (VE), astaxanthin commercial (AC), astaxanthin extracted from white shrimp shells (AE), astaxanthin encapsulation into powder form (AP), and blank powder (BP). The evaluation of liver in response to astaxanthin administration was then assessed in terms of

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Lee, Meng-Chou, Chih-Yang Huang, Jing Huang, Chia-Yu Chang, Po-Tsang Lee, and Fan-Hua Nan. "The Effect of Dietary Supplementation with Haematococcus pluvialis for Enhanced Pigmentation in Amphiprion ocellaris." Aquaculture Research 2023 (December 29, 2023): 1–9. http://dx.doi.org/10.1155/2023/5542730.

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Among the minority seawater species in the ornamental fish market, clownfish (Amphiprion ocellaris) have a high market value due to their vibrant appearance. Astaxanthin, a promising coloring agent, is applied in diets as a food additive to enhance the physical appearance of clownfish. However, as the retail price of astaxanthin has been inflating, the industry is eager to find more affordable astaxanthin products. The present study evaluated the nutrients and pigmentation performance of the algae-extracted astaxanthin diets of clownfish, followed by a comparative feeding trial evaluating the

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Phoproek, Pasinee, Chalermpong Saenjum, and Jidapha Tinoi. "Rice Straw Hydrolysis and Cultivation of Xanthophyllomyces dendrorhous for Astaxanthin Production and Antioxidant Properties." Research Journal of Biotechnology 16, no. 11 (2021): 37–46. http://dx.doi.org/10.25303/1611rjbt3746.

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Astaxanthin is a natural pigment with strong antioxidant activity and is widely supplied as dietary supplement. The red yeast Xanthophyllomyces dendrorhous is one of the potential sources for astaxanthin production. Rice straw was considered for utilization on cultivation and astaxanthin production. Rice straw was treated by autoclave-assisted alkaline pretreatment. and hydrolyzed by cellulase hydrolysis. X. dendrorhous TISTR5730 was cultured and accumulated as the astaxanthin on rice straw hydrolysate. The highest reducing sugar concentration of rice straw hydrolysate was 89.82±0.39g/L (0.71±

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Chang, Ming Xian, and Fan Xiong. "Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions." Molecules 25, no. 22 (2020): 5342. http://dx.doi.org/10.3390/molecules25225342.

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Astaxanthin is a natural lipid-soluble and red-orange carotenoid. Due to its strong antioxidant property, anti-inflammatory, anti-apoptotic, and immune modulation, astaxanthin has gained growing interest as a multi-target pharmacological agent against various diseases. In the current review, the anti-inflammation mechanisms of astaxanthin involved in targeting for inflammatory biomarkers and multiple signaling pathways, including PI3K/AKT, Nrf2, NF-κB, ERK1/2, JNK, p38 MAPK, and JAK-2/STAT-3, have been described. Furthermore, the applications of anti-inflammatory effects of astaxanthin in neur

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TRAN, Tuyet Nhung, Quang-Vinh TRAN, Hao Thanh HUYNH, Nghia-Son HOANG, Hoang Chinh NGUYEN, and Dai-Nghiep NGO. "Astaxanthin Production by Newly Isolated Rhodosporidium toruloides: Optimization of Medium Compositions by Response Surface Methodology." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 47, no. 2 (2018): 320–27. http://dx.doi.org/10.15835/nbha47111361.

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Astaxanthin is a valuable carotenoid pigment, which has been extensively used in various industries. In this study, Rhodosporidium toruloides was first used as a new microbial source for producing natural astaxanthin. Various carbon, nitrogen, and mineral sources were evaluated for their effect on astaxanthin production of R. toruloides. Response surface methodology (RSM) was then used to optimize the medium compositions for maximizing the astaxanthin concentration. Among the examined nutrients, glucose, peptone, and KH2PO4 were the most efficient carbon, nitrogen, and mineral source for astax

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Zhang, Junpeng, Changxu Tian, Kecheng Zhu, et al. "Effects of Natural and Synthetic Astaxanthin on Growth, Body Color, and Transcriptome and Metabolome Profiles in the Leopard Coral Grouper (Plectropomus leopardus)." Animals 13, no. 7 (2023): 1252. http://dx.doi.org/10.3390/ani13071252.

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Natural and synthetic astaxanthin can promote pigmentation in fish. In this study, the effects of dietary astaxanthin on growth and pigmentation were evaluated in leopard coral grouper (Plectropomus leopardus). Fish were assigned to three groups: 0% astaxanthin (C), 0.02% natural astaxanthin (HP), and 0.02% synthetic astaxanthin (AS). Brightness (L*) was not influenced by astaxanthin. However, redness (a*) and yellowness (b*) were significantly higher for fish fed astaxanthin-containing diets than fish fed control diets and were significantly higher in the HP group than in the AS group. In a t

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Pan, Li, Haojie Meng, Jiaqi Li, et al. "Enhancement of Astaxanthin Bioaccessibility by Encapsulation in Liposomes: An In Vitro Study." Molecules 29, no. 8 (2024): 1687. http://dx.doi.org/10.3390/molecules29081687.

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Astaxanthin was encapsulated in liposomes by a thin layer dispersion and ultrasound method using soybean phospholipid. The digestion properties of liposomes for encapsulating astaxanthin were investigated in light of particle size, size distribution, zeta potential, and microstructure during in vitro digestion as a function of time. These results exhibited that the average particle size increased gradually with liposomal vesicles retained round shapes and a fairly uniform distribution after passage through the simulated gastric fluid digestion. The result revealed that astaxanthin-loaded lipos

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Dewanti, P. R., Rochmadi, A. Rohman, and A. Budiman. "Degradation rate of astaxanthin from Haematococcus pluvialis." Food Research 6, no. 4 (2022): 254–58. http://dx.doi.org/10.26656/fr.2017.6(4).462.

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Astaxanthin is an antioxidant that is sensitive to environmental conditions. This study aimed to determine the effect of temperature and lighting on the concentration of astaxanthin, then derive the kinetic equation for its degradation. The half-life was calculated to determine the astaxanthin degradation time at which its concentration drops to half of its initial concentration. Standard astaxanthin was dissolved in acetone and left to stand under three different conditions. The results indicated that temperature and lighting can both cause degradation of astaxanthin. Degradation appeared to

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Li, Feng, Minggang Cai, Mingwei Lin, et al. "Differences between Motile and Nonmotile Cells of Haematococcus pluvialis in the Production of Astaxanthin at Different Light Intensities." Marine Drugs 17, no. 1 (2019): 39. http://dx.doi.org/10.3390/md17010039.

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Haematococcus pluvialis, as the best natural resource of astaxanthin, is widely used in nutraceuticals, aquaculture, and cosmetic industries. The purpose of this work was to compare the differences in astaxanthin accumulation between motile and nonmotile cells of H. pluvialis and to determine the relationship between the two cells and astaxanthin production. The experiment design was achieved by two different types of H. pluvialis cell and three different light intensities for an eight day induction period. The astaxanthin concentrations in nonmotile cell cultures were significantly increased

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Zhao, Wei, Yu-Cai Guo, Ming-Yan Huai, et al. "Comparison of the Retention Rates of Synthetic and Natural Astaxanthin in Feeds and Their Effects on Pigmentation, Growth, and Health in Rainbow Trout (Oncorhynchus mykiss)." Antioxidants 11, no. 12 (2022): 2473. http://dx.doi.org/10.3390/antiox11122473.

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The coloring efficiency and physiological function of astaxanthin in fish vary with its regions. The aim of this study was to compare the retention rates of dietary astaxanthin from different sources and its effects on growth, pigmentation, and physiological function in Oncorhynchus mykiss. Fish were fed astaxanthin-supplemented diets (LP: 0.1% Lucantin® Pink CWD; CP: 0.1% Carophyll® Pink; EP: 0.1% Essention® Pink; PR: 1% Phaffia rhodozyma; HP: 1% Haematococcus pluvialis), or a diet without astaxanthin supplementation, for 56 days. Dietary astaxanthin enhanced pigmentation as well as the growt

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