Academic literature on the topic 'Asthenovegetative syndrome'

This study assesses and systematizes the signs of asthenovegetative syndrome (AVS) in patients who had COVID-19 a month ago. The survey was completed by 44 respondents aged 20 to 80 years. According to the results of the survey, the most common manifestation of asthenovegetative syndrome is weakness. The respondents also noted emotional disturbances, decreased attention, sleep disturbances, pain in the joints and muscles, weight loss, and headache. To assess the dynamics of the studied manifestations, a survey was conducted using the Vein's autonomic dysfunction scale. In 93.1 % of the respondents, the total score exceeded 15, which indicates the presence of autonomic dysfunction. The results demonstrate that among patients who have undergone COVID-19, the frequency of autonomic dysfunction is quite high. The manifestations which patients are most often concerned about are asthenic and psycho-emotional disorders. These consequences of COVID-19 significantly reduce the quality of life, which indicates the need for timely diagnosis and provision of qualified care to patients.

Objective: studying the influence of various factors on the course and outcomes of COVID-19 in children of different ages, to determine patient management tactics.Materials and methods: the article presents the results of a retrospective assessment of the course of COVID-19 in 89 children observed in clinics of Samara city. A comparative analysis of the course of COVID-19 and post-COVID in children of different ages was carried out. Statistical analysis was carried out by IBM SPSS Statistica 25, p<0.05 was considered the criterion for significance.Results: the severity of COVID-19 was independent of age. For children from 3 to 6 years of age, a severe course of ARI in anamnesis mattered, and in the group of children from 7 to 11 years old - compliance with the national calendar of prophylactic vaccinations. Post-COVID had different frequency and duration. In children older than 7 years old, asthenovegetative syndrome occurred more often and was quickly eliminated. In children aged 3-6 years asthenovegetative and dyspeptic syndromes disappeared during a longer period. 2 - 3 months after recovery from COVID-19, exacerbation of allergic diseases was observed in children over 3 years old. Decrease in immunoresistance occurred one month after recovery in children under 6 years of age.Conclusions: it is important to take into account the age-related characteristics of the course of COVID-19 and post-COVID to predict the risks of severe COVID-19 and deterioration of the child’s health.

The purpose of this study was to investigate the systemic microcirculation and main clinical syndromes under the influence of combined and intravenous methods of low-intensive laser therapy (LILT) in patients with chronic pancreatitis (ChP) in acute phase. 123 patients aged 36-77 years old were examined and divided into 2 groups: the experimental (78 patients) and the control group (45 patients). 30 men were in addition surveyed who composed the healthy group. The experimental group has had a complex drug and laser therapy of various therapeutic techniques: I subgroup – intravenous laser blood irradiation (IVLT) and in II group - combined method of laser therapy (LT). Control group has had only drug therapy. The basic clinical syndromes in patients with chronic pancreatitis is the pain, incretory insufficiency, dyspeptic syndrome and asthenovegetative syndrome. The study of microcirculation was carried out by laser Doppler flowmetry on the device LAKK-02 («LAZMA» production, Russia). Heterogeneity of microcirculation types with tht reliable increase of the pathologic types – spastic, hyperemic, congestion-stasis was revealed on the examined patients. Essential improvement of microcirculation condition in patients of experimental group was established, positive influence was revealed on the basic clinical syndromes in phase of chronic pancreatitis exacerbation.

Aim - to study clinical and epidemiological characteristics features of hemorrhagic fever with renal syndrome. Materials and methods. A retrospective comparative analysis of the results of clinical and epidemiological examination of HFRS patients was carried out in two groups: with moderate (n=106) and severe (n=22) forms of the disease, who were hospitalized in the clinic of infectious diseases of Samara State Medical University in 2017. Results. A significant predominance of the air-dust pathway of infection in severe forms of the disease was revealed. Most patients were young men in both groups. Clinical features of the current course of HFRS was the presence of subfebrile temperature in the polyuric period; absence of hemorrhagic syndrome in the majority of patients with HFRS, presence of severe asthenovegetative syndrome in the period of convalescence with severe headache, especially in severe form of the disease.

Introduction. Today, non-alcoholic fatty liver disease (NAFLD) is increasingly associated with the presence or risk of developing type 2 diabetes (D2). The term “hepatogenic diabetes”, proposed to refer to SD2 in patients with cirrhosis of the liver (CP), has acquired a new meaning, since this combination is of growing interest. The authors analyzed the current literature and summarized data on the pathogenesis, risk factors, and possible therapy of NAFLD.Objective: to evaluate the effectiveness of L-ornithine-L-aspartate (HEPA-Merz, Merz Pharma GmbH & Co) in combination with biguanides in the treatment of NAFLD patients in combination with D2.Materials and methods. The study included 30 patients aged 26 to 60 years with a verified diagnosis of NAFLD of varying degrees of activity in combination with D2. All patients were prescribed combination therapy with the drug HEPA-Merz (“Merz Pharma GmbH and Co”) at a dose of 3 grams 3 times a day in combination with biguanides. The examination was performed on the 1st, 28-th and 56-th days of treatment. In order to determine the effectiveness of therapy, we evaluated the dynamics of clinical symptoms (asthenovegetative, dyspeptic syndromes, pain syndrome in the ball system), biochemical parameters of liver function (changes in markers of cytolysis, cholestasis), lipidogram indicators, glucose levels, glycated hemoglobin, and ultrasound results of abdominal organs.Results. On day 56, asthenovegetative, dyspeptic and pain syndrome were stopped during therapy. Most patients showed a decrease in body weight from 3 to 5 kg. When evaluating changes in biochemical parameters on the 28-th day, the activity of ALT, AST, GGTP and glucose levels significantly decreased against the background of the therapy. On the 56th day of treatment, the activity of transaminases, bilirubin, GGTP and GFR in all patients were within the reference values.Conclusion. Understanding the multifactorial nature of NAFLD and the mechanisms of associated diseases, including D2, will allow us to assess the prognosis of the disease and prescribe adequate timely therapy. The effectiveness of the original ornithineaspartate (Merz Pharma GmbH & Co.) is manifested by a decrease in the processes of cytolysis of hepatocytes, normalization of lipid and carbohydrate metabolism.

BACKGROUND: High incidence of acute respiratory viral infections In primary school children, associated with a combination of factors such as critical age periods and lifestyle changes with a redistribution of psychophysical loads, requires a more detailed study of the psycho-emotional state of children during the period of convalescence after acute respiratory viral infection. AIM: To asses the psychoemotional state of primary school-age children within six months after acute respiratory viral infections, taking into account its severity and form. METHODS: 430 children of 7–9 years of age enrolled in schools in Lugansk were examined. 246 children had a history of acute respiratory viral infections (main group) and 184 children had of acute respiratory viral infections (comparison group). The observation period lasted from September 2023 to February 2024. The analysis of the psychoemotional well-being of children in the first half of the year after acute respiratory viral infections was carried out. Children neurosis questionnaire (V.V. Sednev et al., 1997), analysis of medical documentation (form No. 025/u-04, No. 112/u), methodology of E.M. Alexandrovskaya, St. Grombakh were used. RESULTS: A decrease in concentration and increased anxiety were revealed when children returned to school after acute respiratory viral infection. The maximum values were recorded within two weeks, and 59,76% of the children needed psychological counseling. As time passed, the symptoms subsided, but remained present in comparison with children without acute respiratory viral infections. In the main group, high asthenia scores were found, 2,3 times higher than in the control (p 0,001). Тhe asthenovegetative syndrome on the nosological form of acute respiratory viral infections was revealed, with maximum prevalence in influenza and infectious mononucleosis (p 0,05). CONCLUSION: Disorders in the psycho-emotional sphere after acute respiratory viral infections in children were observed for 2 to 6 months. The asthenovegetative syndrome persisted for a long time, the degree of which depended on the etiology and severity of the course of acute respiratory viral infections. The data obtained should be taken into account in the educational process and psychological and pedagogical support of children in educational institutions.

The COVID-19 pandemic has posed many challenges to the medical community, a number of which will remain in the near future. Analysis of clinical cases helps to identify problems, to plan future research, which can change the understanding of the consequences of the disease. As the first year of the pandemic progresses, there is a better understanding of the pathophysiology of the virus and the varied results of imaging COVID-19 in affected organs, which is crucial for improving the treatment of this complex disease and improving health outcomes. It is described a clinical case of exanthema in an 11-year-old patient after COVID-19. Clinical and immunological methods of investigation are used. The child’s condition was of the moderate severity, caused by skin and asthenovegetative syndromes. The child was diagnosed with COVID-19; fatigue syndrome after a viral illness; post COVID-19 exanthema infection crustal ichthyosis of the legs. A particular feature of this case is the occurrence of exanthema on the skin of the child after COVID-19. In these cases, the awareness of pediatricians should be raised to increase the level of knowledge of the correct diagnostic algorithm. No conflict of interests was declared by the authors.

Introduction. To determine the tactics of management of chronic lymphoproliferative syndrome in young children, a comprehensive examination is necessary. Herpesvirus infection (HVI) plays an important role in the etiology of hypertrophy of lymphoid formations of the pharynx.Purpose. To evaluate the results of preoperative diagnosis of chronic lymphoproliferative syndrome in children in early childhood.Materials and methods. In 96 patients aged 1 to 3 years 11 months with lymphoproliferative syndrome more than 3–6 months, endoscopy, otomicroscopy, impedance, ultrasound examination of abdominal organs, cervical and submandibular lymph nodes, serological and molecular genetic analyses of markers of EBV, CMV, HCV-6 in the blood; PCR in pharyngeal tonsil scrapings were performed.Results and discussion. The clinical picture in children with chronic lymphoproliferative syndrome of younger age was dominated by complaints of difficulty in nasal breathing, snoring in 42% of children, recurrent otitis in 58%, manifestations of asthenovegetative and intoxication syndromes and frequent acute respiratory viral infections in 70% of patients. A high degree of infection of children of the younger age group was revealed – HCV-6 in 87%, CMV in 63% of children, 46% – EBV. And high activity of the infectious process in 31% of patients for all three GVI, more often for EBV in 27%. A combination of two or three GVI was detected in 83% of patients. During instrumental examination, a high degree of hypertrophy of the nasopharyngeal tonsils (adenoid vegetations of 2–3 degrees – 67% and 3 degrees – 18%, combined with hypertrophy of the palatine tonsils in 27% of cases), an increase in neck lymph nodes of more than 16mm, including lymph node packs in 28% of younger children and reactive hepatosplenomegaly in 17.7% of patients.Conclusion. To determine the tactics of management of chronic lymphoproliferative syndrome in young children, it is important to assess the severity of lymphoproliferative syndrome according to the clinical picture and instrumental research methods (nasopharyngeal endoscopy, ultrasound examination of neck and abdominal lymph nodes) in combination with laboratory data and characteristics of the stage of activity of the infectious process of herpesvirus etiology.

Введение. Гепатобилиарная система неразрывно взаимодействует с микробиотическим биоценозом кишечника в процессах детоксикации, метаболизма, формирования и регуляции общего и местного иммунитета. Цель исследования — изучение микробного состава толстой кишки у больных хроническим вирусным гепатитом В, сочетанным с дисбиозом кишечника, в динамике в ходе лечения. Материалы и методы. Было обследовано 72 пациента с диагнозом «хронический вирусный гепатит В» (ХВГВ) с признаками нарушения популяционного содержания микробиоты толстой кишки, распределенных на две группы. Диагноз ХВГВ подтверждали посредством серологических маркеров вирусного гепатита В, обнаружения генетического материала (HBV-DNA). Состояние микрофлоры изучали микробиологическим методом с помощью засева десятикратных разведений стула на дифференциально-диагностические питательные среды. Обе группы больных получали этиотропную терапию ХВГВ (энтекавир), пациентам основной группы в дополнение назначали синбиотик. Результаты и обсуждение. Обострение ХВГВ у больных с дисбалансом микробиоценоза толстой кишки, как правило, характеризуется наличием астеновегетативного синдрома, синдрома «правого подреберья», внепеченочных проявлений, синдрома кишечной диспепсии. В биохимическом плане отмечается ухудшение «функциональных проб печени»: гипербилирубинемия и цитолитический синдром умеренной степени выраженности. При микробиологическом исследовании фекалий установлено уменьшение количества лакто- и бифидобактерий, увеличение количества Esherichia coli с низкой ферментативной активностью, а также рост условно-патогенных микроорганизмов. Включение препаратадля нормализации микрофлоры желудочно-кишечного тракта в терапию ХВГВ способствует более быстрому регрессу астеновегетативных проявлений, синдрома «правого подреберья» и кишечной диспепсии, нормализации пигментного обмена и уровня аминотрансфераз, а также восстановлению баланса облигатной и факультативной микрофлоры кишечника. Заключение. В результате исследования выяснилось, что использование средств общепринятой терапии у больных с ХВГВ с дисбиозом кишечника не обеспечивает восстановление популяционного содержания микробиоты, поэтому считаем целесообразным назначение пре- и пробиотических препаратов больным с данной сочетанной патологией. Introduction. The hepatobiliary system inextricably interacts with the microbiotic biocenosis of the intestine in the processes of detoxification, metabolism, formation and regulation of general and local immunity. The aim of the study was to study the microbial composition of the colon in patients with chronic viral hepatitis B, combined with intestinal dysbiosis in dynamics during treatment. Materials and methods. We examined 72 patients diagnosed with chronic viral hepatitis B with signs of impaired population content of the colon microbiota, divided into two groups. The diagnosis of viral hepatitis B was confirmed by serological markers of viral hepatitis B, detection of genetic material (HBV-DNA). The state of the microflora was studied microbiologically by sowing tenfold dilutions of stool on differential diagnostic nutrient media. Both groups of patients received etiotropic therapy (entecavir), patients of the main group were additionally prescribed synbiotic. Results and discussion. Exacerbation of chronic viral hepatitis B in patients with imbalance of microbiocinosis of the colon, as a rule, is characterized by the presence of asthenovegetative syndrome, “right hypochondrium” syndrome, extrahepatic manifestations, intestinal dyspepsia syndrome. In biochemical terms, there is a deterioration in the “functional tests of the liver”: hyperbilirubinemia and cytolytic syndrome of moderate severity. Microbiological examination of feces revealed a decrease in the number of lactoand bifidobacteria, an increase in Esherichia coli with low enzymatic activity, as well as the growth of conditionally pathogenic microorganisms. The inclusion of a drug to normalize the gastrointestinal microflora in the treatment of chronic viral hepatitis B contributes to a faster regression of asthenovegetative manifestations, right hypochondrium syndrome and intestinal dyspepsia, normalization of pigment metabolism and aminotransferase levels, as well as restoration of the balance of obligate and facultative intestinal microflora. Conclusion. As a result of the study, it turned out that using of conventional therapy in patients with chronic viral hepatitis B with intestinal dysbiosis does not ensure the restoration of the population content of the microbiota, therefore, we consider it advisable to prescribe pre- and probiotic drugs to patients with this combined pathology.

Статья посвящена проблеме последствий перенесенной инфекции COVID-19 у детей. Рассмотрены основные факторы риска развития long COVID-19 у детей: возраст (чаще постковидный синдром развивается у детей старшего возраста); наличие в анамнезе аллергических реакций, неврологических заболеваний, патологии органов дыхания; избыточный вес (ожирение); тяжелое течение COVID-19. Приводится определение постковидного синдрома, выделены его основные проявления у детей: преимущественно функциональный характер клинических проявлений; преобладание в структуре неврологических нарушений головных болей и астенизации; выраженный характер проявлений постковидной клинической симптоматики; усиление симптомов со стороны преморбидной неврологической патологии; высокая длительность симптомов постковидных нарушений, что может указывать на неэффективность традиционных методов их лечения и реабилитации. Отмечено, что когнитивные нарушения при астеновегетативных проявлениях инфекции COVID-19 более выражены, чем после других инфекционных заболеваний. The article deals with the problem of the consequences of the past COVID-19 infection in children. The main risk factors for the development of long COVID-19 in children are considered, such as: age (more often post-COVID syndrome has been developed in older children); a history of allergic reactions, neurological diseases, pathology of the respiratory system; overweight (obesity); severe course of COVID-19.The definition of post-COVID syndrome is given, its main manifestations in children are highlighted: predominantly functional nature of clinical manifestations; predominance of headaches and asthenia in the structure of neurological disorders; pronounced nature of the manifestations of post-COVID clinical symptoms; increased symptoms of premorbid neurological pathology; long duration of post-COVID disorders symptoms, which may be indicative for ineffectiveness of conventional treatment and rehabilitation methods. It was noted that cognitive impairment in asthenovegetative manifestations of COVID-19 infection was more pronounced than after other infectious diseases.