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1

Chernaya, N. L., O. V. Fomina, and I. V. Ivanova. "Impulse oscillometry as a method of diagnosis of early respiratory dysfunction in asthmatic children." PULMONOLOGIYA, no. 4 (August 28, 2007): 62–68. http://dx.doi.org/10.18093/0869-0189-2007-0-4-62-68.

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We have assessed diagnostic value of impulse oscillometry for recognition of early respiratory dysfunction in asthmatic adolescents. There were 242 adolescents aged 10 to 17 under the supervision. Of them, 223 had mild stable asthma and 19 were as controls without respiratory dysfunction. According to clinical features, asthma control level and treatment all the asthmatic adolescents were subdivided into 5 groups. Lung ventilation was examined with MasterScreenBody (Erich Jaeger, Gmbh) MasterIOS including impulse oscillometry and spirometry. The impulse oscillometry can be very helpful in assessment of severity and location of respiratory obstruction in asthmatic adolescent with normal spirometric parameters.
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Vázquez-Nava, Francisco, José María Peinado-Herreros, Atenógenes H. Saldívar-Gonzalez, Ma Del Carmen Barrientos-Gómez, Francisco J. Beltrán-Guzmán, Jesus Perez-Martin, José A. Cordóva-Fernández, and Carlos F. Vázquez-Rodríguez. "Association between Family Structure, Parental Smoking, Friends Who Smoke, and Smoking Behavior in Adolescents with Asthma." Scientific World JOURNAL 10 (2010): 62–69. http://dx.doi.org/10.1100/tsw.2010.10.

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Recent investigations show that the smoking prevalence among asthmatic adolescents is higher than among healthy adolescents, and the causes that lead these asthmatic adolescents to smoke are unclear. We investigated the association between family structure, parental smoking, smoking friends, and smoking in asthmatic adolescents (n = 6,487). After adjusting for sex and age, logistic regression analyses showed that nonintact family structure, parental smoking, and smoking friends are associated with smoking in adolescents with and without asthma. Asthmatic adolescents who reside in the household of a nonintact family have a 1.90 times greater risk of smoking compared with those who live with both biological parents. It is important that parents who have children with asthma be made aware that the presence of smokers in the home and adolescent fraternization with smoking friends not only favor the worsening of asthma, but also induce the habit of smoking.
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Lopes, Wendell Arthur, Fernanda Errero Porto, and Neiva Leite. "EFFECT OF PHYSICAL TRAINING ON EXERCISE-INDUCED BRONCHOSPASM IN YOUNG ASTHMATICS." Revista Brasileira de Medicina do Esporte 26, no. 1 (February 2020): 77–81. http://dx.doi.org/10.1590/1517-869220202601201675.

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ABSTRACT Introduction: Asthma is the most common chronic disease in childhood and its prevalence has increased in recent years. Although regular physical activity (PA) is considered to be beneficial for the health of asthmatics, especially children and adolescents, it can also be one of the elements that triggers asthma. This is known as exercise-induced bronchospasm (EIB), and is considered one of the factors that limits asthmatics’ participation in PA. Objective: This study aims to review the effects of physical conditioning on EIB in asthmatic children and adolescents. Methods: A systematic review was carried out on the Pubmed, Bireme and Web of Science databases, considering publications from 1998 to April 2019. Results: Eight articles were retrieved; five of the articles presented no significant difference in EIB parameters after physical training, and three demonstrated significant benefits in EIB. Conclusion: There is insufficient evidence that physical training helps reduce the frequency and severity of EIB in young asthmatics. There are still few studies that seek to show the effect of a physical training program on the improvement of EIB in children and adolescents. It is suggested that further randomized clinical trials be conducted, to investigate the effects of physical training on EIB parameters in children and adolescents. Level of Evidence II; Systematic review.
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Nordin, James, Gabriela Vazquez-Benitez, Avalow Olsen, Leslie Kuckler, and Elyse Kharbanda. "985. Safety of Guidelines Recommending LAIV for Routine Use in Children and Adolescents With Asthma." Open Forum Infectious Diseases 5, suppl_1 (November 2018): S291. http://dx.doi.org/10.1093/ofid/ofy210.822.

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Abstract Background Asthma is the most common chronic medical condition in children. Prior observational studies of live attenuated influenza vaccine (LAIV) safety in asthmatic children have been limited due to confounding by indication, with LAIV restricted to patients with mild asthma. To minimize bias, we evaluated safety of LAIV in children with asthma using a natural experiment in which two medical groups, within a single health system, serving similar populations, differed in vaccination guidelines. Prior to 2010 both groups recommended inactivated influenza vaccine (IIV). Starting in 2010, one group recommended LAIV for children with asthma. Methods Asthmatic children age 2–18 years with visits to two large medical groups in the upper Midwest from 2007 to 2015 were identified and classified by severity and control using validated algorithms. Primary outcomes were lower respiratory events (LRE) occurring within 21 and 42 days after influenza immunization. Multiple records per subject were included when children received influenza vaccines in more than one season. The analysis was intention to treat with each medical group’s subjects analyzed as a group. A pre-/post-ratio of ratios (ROR) approach was used to estimate the LAIV guideline impact using a generalized linear model with a Poisson distribution, accounting for multiple records per subject and adjusting for age and asthma classification. Analyses were for the overall population, and stratified by age group: 2–4 and 5–18 years. Results A total of 7,959 observations from 4,824 unique asthmatic children were analyzed, with 1,896 from the IIV guideline and 6,061 from the LAIV guideline medical groups. Postimplementation, 67% received LAIV. Age and asthma classification adjusted ROR showed no increase in LREs using the LAIV guideline: overall ROR (95% CI): 0.79 (0.46–1.37) for LRE 21 days and 0.82 (0.56–1.20) for 42 days; age 2–4: 1.07 (0.40–2.83) for 21 days and 1.0 (0.53–1.90) for 42 days; and age 5–18: 0.72 (0.37–1.41) for 21 days and 0.75 (0.46–1.21) for 42 days. Conclusion A guideline recommending LAIV rather than IIV for asthmatic children did not result in more LREs following vaccination in children age 2–18. Guidelines for influenza vaccination in asthmatic children should be based on effectiveness studies. Disclosures All authors: No reported disclosures.
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Sansone, Francesco, Marina Attanasi, Sabrina Di Pillo, and Francesco Chiarelli. "Asthma and Obesity in Children." Biomedicines 8, no. 7 (July 21, 2020): 231. http://dx.doi.org/10.3390/biomedicines8070231.

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Asthma and obesity are two major chronic diseases in children and adolescents. Recent scientific evidence points out a causative role of obesity in asthma predisposition. However, studies assessing the real impact of excessive weight gain on lung function in children have shown heterogeneous results. In this review, the pathological mechanisms linking obesity and development of asthma in children are summarized and factors influencing this relationship are evaluated. Common disease modifying factors including age, sex, ethnicity, development of atopic conditions, and metabolic alterations significantly affect the onset and phenotypic characteristics of asthma. Given this, the impact of these several factors on the obesity–asthma link were considered, and from revision of the literature we suggest the possibility to define three main clinical subtypes on the basis of epidemiological data and physiological–molecular pathways: obese-asthmatic and atopy, obese-asthmatic and insulin-resistance, and obese-asthmatic and dyslipidemia. The hypothesis of the different clinical subtypes characterizing a unique phenotype might have an important impact for both future clinical management and research priorities. This might imply the necessity to study the obese asthmatic child with a “multidisciplinary approach”, evaluating the endocrinological and pneumological aspects simultaneously. This different approach might also make it possible to intervene earlier in a specific manner, possibly with a personalized and tailored treatment. Surely this hypothesis needs longitudinal and well-conducted future studies to be validated.
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BROOK, U., and Y. BENJAMINI. "Self-esteem of Asthmatic Children and Adolescents: A Pilot Study." Pediatric Asthma, Allergy & Immunology 7, no. 3 (January 1993): 167–71. http://dx.doi.org/10.1089/pai.1993.7.167.

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Angela Tosca, Maria, Gian Luigi Marseglia, Giorgio Ciprandi, and ControL’Asma” Study Group. "The real-world “ControL’Asma” study: a nationwide taskforce on asthma control in children and adolescents." Allergologia et Immunopathologia 49, no. 1 (January 2, 2021): 32–39. http://dx.doi.org/10.15586/aei.v49i1.14.

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Background: Asthma control is the goal of asthma management. A nationwide study on this aspect was launched by the Italian Society of Paediatric Allergy and Immunology (ControL’Asma study). Objective: To define variables associated with different asthma control grades in a nationwide population of asthmatic children and adolescents. Methods: This cross-sectional real-world study included 480 asthmatic children and adolescents (333 males, median age 11.2 years) consecutively enrolled in 10 third level pediatric allergy clinics. According to the Global Initiative for Asthma (GINA) document, history, medication use, perception of asthma symptoms assessed by visual analog scale (VAS), clinical examination, lung function, childhood asthma control test (cACT)/asthma control test (ACT), and asthma control level were evaluated. Results: Considering GINA criteria, asthma was well controlled in 55% of patients, partly controlled in 32.4%, and uncontrolled in 12.6%. Regarding cACT/ACT, asthma was uncontrolled in 23.2%. Patients with uncontrolled asthma had the lowest lung function parameters and VAS scores, more frequent bronchial obstruction and reversibility, and used more oral and inhaled corticosteroids (CS). Conclusions: The ControL’Asma study, performed in a real-world setting, showed that asthma in Italian children and adolescents was usually more frequent in males. Asthmatic patients had an early onset and allergic phenotype with very frequent rhinitis comorbidity. Uncontrolled and partly controlled asthma affected about half of the subjects, and the assessment of asthma symptom perception by VAS could be a reliable tool in asthma management.
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Ahmadizar, Fariba, Susanne J. H. Vijverberg, Hubertus G. M. Arets, Anthonius de Boer, Jason E. Lang, Meyer Kattan, Colin N. A. Palmer, Somnath Mukhopadhyay, Steve Turner, and Anke H. Maitland-van der Zee. "Childhood obesity in relation to poor asthma control and exacerbation: a meta-analysis." European Respiratory Journal 48, no. 4 (September 1, 2016): 1063–73. http://dx.doi.org/10.1183/13993003.00766-2016.

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To estimate the association between obesity and poor asthma control or risk of exacerbations in asthmatic children and adolescents, and to assess whether these associations are different by sex.A meta-analysis was performed on unpublished data from three North-European paediatric asthma cohorts (BREATHE, PACMAN (Pharmacogenetics of Asthma medication in Children: Medication with Anti-inflammatory effects) and PAGES (Pediatric Asthma Gene Environment Study)) and 11 previously published studies (cross-sectional and longitudinal studies). Outcomes were poor asthma control (based on asthma symptoms) and exacerbations rates (asthma-related visits to the emergency department, asthma-related hospitalisations or use of oral corticosteroids). Overall pooled estimates of the odds ratios were obtained using fixed- or random-effects models.In a meta-analysis of 46 070 asthmatic children and adolescents, obese children (body mass index ≥95th percentile) compared with non-obese peers had a small but significant increased risk of asthma exacerbations (OR 1.17, 95% CI 1.03–1.34; I2: 54.7%). However, there was no statistically significant association between obesity and poor asthma control (n=4973, OR 1.23, 95% CI 0.99–1.53; I2: 0.0%). After stratification for sex, the differences in odds ratios for girls and boys were similar, yet no longer statistically significant.In asthmatic children, obesity is associated with a minor increased risk of asthma exacerbations but not with poor asthma control. Sex does not appear to modify this risk.
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Hansen, Karen Kaae, Eva Mosfeldt Laursen, Vibeke Backer, Niels Bach-Mortensen, Palle Prahl, and Christian Koch. "Bronchial Responsiveness in Children and Adolescents: A Comparison Between Previously Asthmatic, Currently Asthmatic, and Normal Subjects." Journal of Asthma 31, no. 2 (January 1994): 99–107. http://dx.doi.org/10.3109/02770909409044812.

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Cag, Yakup, Funda Gumustas, and Yasemin Yulaf. "Psychiatric disorders and characteristics of patients in asthmatic children and adolescents." Annals of Medical Research 27, no. 6 (2020): 1606. http://dx.doi.org/10.5455/annalsmedres.2020.02.162.

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11

PAGANINI, MÔNICA, CÁSSIA CILENE DEZAN, THIAGO RODRIGO BICHACO, FLAVIANA BOMBARDA De ANDRADE, ALCINDO CERCI NETO, and KAREN BARROS PARRON FERNANDES. "Dental caries status and salivary properties of asthmatic children and adolescents." International Journal of Paediatric Dentistry 21, no. 3 (February 1, 2011): 185–91. http://dx.doi.org/10.1111/j.1365-263x.2010.01109.x.

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12

Manuyakorn, Wiparat, Chalerat Direkwattanachai, Suwat Benjaponpitak, Wasu Kamchaisatian, Cherapat Sasisakulporn, and Wanlapa Teawsomboonkit. "Sensitivity of Turbutester and Accuhaler tester in asthmatic children and adolescents." Pediatrics International 52, no. 1 (February 2010): 118–25. http://dx.doi.org/10.1111/j.1442-200x.2009.02904.x.

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Genov, Isabel Rugue, Angela Falcai, Alessandra Pontillo, Antonio Condino Neto, Marcia Carvalho Mallozi, and Dirceu Sole. "Gene polymorphisms as susceptibility factors in Brazilian asthmatic children and adolescents." World Allergy Organization Journal 8 (2015): A235. http://dx.doi.org/10.1186/1939-4551-8-s1-a235.

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14

Warner. "Unmet needs in the treatment of asthmatic children and adolescents: 1." Clinical & Experimental Allergy 30 (June 2000): 70–72. http://dx.doi.org/10.1046/j.1365-2222.2000.00102.x.

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Björkstén. "Unmet needs in the treatment of asthmatic children and adolescents: 2." Clinical & Experimental Allergy 30 (June 2000): 73–76. http://dx.doi.org/10.1046/j.1365-2222.2000.00103.x.

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16

Tal, Asher, Hans Pasterkamp, and Victor Chernick. "Endogenous opiates and response to exercise in asthmatic children and adolescents." Pediatric Pulmonology 1, no. 1 (January 1985): 46–51. http://dx.doi.org/10.1002/ppul.1950010111.

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17

Cordeiro, Jean Aretakis, Caroline Palácio Silva, Murillo Carlos Amorim Britto, and Lívia Barboza Andrade. "Static and dynamic evaluation of respiratory muscle strength in asthmatic children and adolescents." Revista Brasileira de Saúde Materno Infantil 20, no. 4 (December 2020): 1009–16. http://dx.doi.org/10.1590/1806-93042020000400006.

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Abstract Objectives: to evaluate static and dynamic respiratory muscle strength in children and adolescents with asthma. Methods: cross-sectional study, involving 80 children and adolescents, 40 with asthma and 40 healthy controls. Biological and clinical characteristics were analyzed. The analysis of the dynamic inspiratory muscle strength was obtained using the KH5 device of the POWERbreathe® line, while the static evaluation was performed using an analog manova-cuometer. Results: the mean obtained from the S-Index was higher in the control group compared to asthmatics (p = 0.026). There was no statistical difference between MIP values for asthmatics and predicted values (p = 0.056). The MEP results showed a significant difference between the mean of the cases and the predicted values (p = 0.000). There was a positive correlation between height and S-Index (p = 0.002 and r = 0.438). Conclusion: the present study demonstrated that the static inspiratory muscle strength (PImáx) of children and adolescents with asthma in comparison with the values predicted in the literature does not differ, however, when submitted to dynamic assessment (S-Index), it presents higher values in healthy controls. In addition, the S-Index showed a positive correlation with the child's height.
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Morishita, Rosinha, Maria do Carmo Franco, Fabíola Isabel Suano-Souza, Dirceu Solé, Rosana Fiorini Puccini, and Maria Wany Louzada Strufaldi. "Body mass index, adipokines and insulin resistance in asthmatic children and adolescents." Journal of Asthma 53, no. 5 (January 20, 2016): 478–84. http://dx.doi.org/10.3109/02770903.2015.1113544.

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Pedroletti, Christophe, Joachim Lundahl, Kjell Alving, and Gunilla Hedlin. "Exhaled nitric oxide in asthmatic children and adolescents after nasal allergen challenge." Pediatric Allergy and Immunology 16, no. 1 (February 2005): 59–64. http://dx.doi.org/10.1111/j.1399-3038.2005.00200.x.

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Sternberg, Alex, Sucharita Bhaumik, Michael Kalinski, Hiren Muzumdar, Madu Rao, and Haesoon Lee. ""Undiagnosed EIB in Obese Non-asthmatic Children and Adolescents Undergoing Exercise Therapy"." Medicine & Science in Sports & Exercise 40, Supplement (May 2008): S414. http://dx.doi.org/10.1249/01.mss.0000322764.45912.f3.

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Ducharme, Francine M., Francisco Noya, David McGillivray, Sandy Resendes, Stéphanie Ducharme-Bénard, Roger Zemek, Sanjit Kaur Bhogal, and Rachel Rouleau. "Two for One: A Self-Management Plan Coupled with a Prescription Sheet for Children with Asthma." Canadian Respiratory Journal 15, no. 7 (2008): 347–54. http://dx.doi.org/10.1155/2008/353402.

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BACKGROUND: Despite strong recommendations in the asthma guidelines, the use of written self-management plans remains low among asthmatic patients.OBJECTIVES: To develop a written self-management plan, based on scientific evidence and expert opinions, in a format intended to facilitate its dispensing by health care professionals, and to test the perception of its relevance and clarity by asthmatic children, adolescents and adults.METHODS: Inspired by previously tested self-management plans, surveys of asthma educators, expert opinions and the 2004 Canadian Asthma Guidelines, the authors simultaneously developed French and English versions of a written self-management plan that coupled with a prescription. The self-management plan was tested in parents and their asthmatic children (aged one to 17 years), and it was revised until 85% clarity and perceived relevance was achieved.RESULTS: Ninety-seven children and their parents were interviewed. Twenty per cent had a self-management plan. On the final revision, nearly all items were clear and perceived relevant by 85% or more of the interviewees. Two self-management plans were designed for clinics and acute care settings, respectively. The plans are divided into three control zones identified by symptoms with optional peak flow values and symbolized by traffic light colours. They are designed in triplicate format with a prescription slip, a medical chart copy and a patient copy.CONCLUSION: The written self-management plans, based on available scientific evidence and expert opinions, are clear and perceived to be relevant by children, adolescents and their parents. By incorporating the prescription and chart copies, they were designed to facilitate dispensing by physicians in both clinics and acute care settings.
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Mosayebi, Mahdi, Latif Moini, Reza Hajihossein, Mojtaba Didehdar, and Zahra Eslamirad. "Detection of Specific Antibody Reactivity to Toxocara Larval Excretory-secretory Antigens in Asthmatic Patients (5-15 Years)." Open Microbiology Journal 10, no. 1 (October 31, 2016): 162–67. http://dx.doi.org/10.2174/1874285801610010162.

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Background & Purpose: Humans act as an intermediate host for Toxocara canis and Toxocara cati. Toxocara may be an important risk factor for asthma in humans. The aim of the present study was to evaluate immunoglobulin G (IgG) anti-Toxocara canis antibody, using enzyme-linked immunosorbent assay (ELISA) in asthmatic patients (aged 5-15 years), referring to a clinic of pulmonary diseases in Arak, Iran. Materials & Methods: In this bi-group cross sectional study, serum samples were collected from 110 children with confirmed asthma and 70 children without asthma within one year. IgG anti-Toxocara antibody was detected via ELISA method. The collected data were analyzed, using SPSS. Results: The seroprevalence of antibodies against Toxocara species was estimated at 1.8% (two males) in asmathic children via ELISA method; however, no antibodies against Toxocara canis were detected in the control group. There was no significant correlation between the frequency of antibodies against Toxocara and variables such as age, gender, or place of residence (P>0.05). Moreover, the frequency of antibodies against Toxocara was not significantly correlated with contact with dogs, consumption of unwashed fruits and vegetables, or use of raw/undercooked sheep liver (P>0.05). Conclusion: The present study showed anti-Toxocara antibody in 1.8% of asthmatic children and determined the seroprevalence of toxocariasis in asthmatic children and adolescents in Arak, Iran. Based on the findings, the low rate of infection with Toxocara among asthmatic children may be attributed to acceptable personal hygiene and religious considerations.
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Fritz, Gregory K., Keren Rosenblum, Robert B. Klein, Elizabeth L. McQuaid, Jack H. Nassau, Marianne Z. Wamboldt, Rick Carter, and Anthony Mansell. "Improved Methodology for Threshold Detection Studies in Asthmatic Children." Journal of Psychophysiology 15, no. 3 (July 2001): 190–97. http://dx.doi.org/10.1027//0269-8803.15.3.190.

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Abstract This paper reports the differences between two methodologies for threshold detection of added resistive loads in children and adolescents. The first-generation apparatus utilized a series of laminar flow screens to present various total resistances, while in the second generation the apparatus utilized a servo-controlled cone that occluded an aperture to varying degrees. Protocol modifications in the second generation methodology included forced choice, attentional enhancements, and larger increments of added resistance. Two studies conducted 2 years apart provided data on the first and second generations of methodology. All participants in Study 1 (N = 33) and Study 2 (N = 33) were children with asthma. Subjects were matched for both age and asthma severity. Results showed the methodologic improvements in the second generation to be significant. Tracking and random thresholds were achieved by 85% and 82% of the subjects in Study 2 compared to 76% and 42% in Study 1, respectively. The correlation between the mean tracking and random thresholds was .40 in Study 2 compared to a statistically insignificant result in Study 1, indicating improved reliability. Raw thresholds were correlated with intrinsic resistance in both studies (r = .29-.88), supporting the use of Weber's Law in resistive loading studies of children. Results using the second generation methodologic improvements demonstrate that children as young as age 7 can complete resistance loading protocols. Standard methodology will enhance the comparability between studies.
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Brook, U., and I. Tepper. "Self image, coping and familial interaction among asthmatic children and adolescents in israel." Patient Education and Counseling 30, no. 2 (February 1997): 187–92. http://dx.doi.org/10.1016/s0738-3991(96)00945-7.

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Gustafsson, Per M. "Pulmonary gas trapping increases in asthmatic children and adolescents in the supine position." Pediatric Pulmonology 36, no. 1 (May 21, 2003): 34–42. http://dx.doi.org/10.1002/ppul.10310.

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Runge, Claus, Josef Lecheler, Michael Horn, Jan-Torsten Tews, and Marion Schaefer. "Outcomes of a Web-Based Patient Education Program for Asthmatic Children and Adolescents." Chest 129, no. 3 (March 2006): 581–93. http://dx.doi.org/10.1378/chest.129.3.581.

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Jentzsch, N. S., P. A. M. Camargos, E. A. Colosimo, and J. Bousquet. "Monitoring adherence to beclomethasone in asthmatic children and adolescents through four different methods." Allergy 64, no. 10 (October 2009): 1458–62. http://dx.doi.org/10.1111/j.1398-9995.2009.02037.x.

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Mostafa, G. A., S. M. Reda, M. M. Abd El-Aziz, and S. A. Ahmed. "Sputum neurokinin A in Egyptian asthmatic children and adolescents: relation to exacerbation severity." Allergy 63, no. 9 (September 2008): 1244–47. http://dx.doi.org/10.1111/j.1398-9995.2008.01784.x.

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El-Sayed, Zainab A., Rasha T. Hamza, Nasr El-Din A. Sayed, and Nermine H. Mahmoud. "Effect of Inhaled Corticosteroids on Growth and Puberty in Egyptian Asthmatic Children and Adolescents." Pakistan Journal of Biological Sciences 13, no. 20 (October 1, 2010): 977–84. http://dx.doi.org/10.3923/pjbs.2010.977.984.

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Fahmy, RehamF, HalaG Elnady, LobnaS Sherif, HalaD ElGindi, FatmaA Shaaban, AidaM Abdelmohsen, DinaA Salah, and GhadaA Abdel-Latif. "Assessment of quality of life of primary caregivers of Egyptian asthmatic children and adolescents." Indian Journal of Community Medicine 45, no. 4 (2020): 410. http://dx.doi.org/10.4103/ijcm.ijcm_436_19.

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Licari, Amelia, Riccardo Castagnoli, Martina Votto, Ilaria Brambilla, Giorgio Ciprandi, and Gian Luigi Marseglia. "Biologic Use in Allergic and Asthmatic Children and Adolescents During the COVID-19 Pandemic." Pediatric Allergy, Immunology, and Pulmonology 33, no. 3 (September 1, 2020): 155–58. http://dx.doi.org/10.1089/ped.2020.1214.

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Naiim, I., F. Tubach, S. Guillo, A. Ajrouche, V. Houdouin, Y. De Rycke, and F. Kaguelidou. "P48 Prescribing patterns of antiasthma medication in children and adolescents in primary care in france." Archives of Disease in Childhood 104, no. 6 (May 17, 2019): e37.1-e37. http://dx.doi.org/10.1136/archdischild-2019-esdppp.86.

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BackgroundLittle is known about the short and long-term therapeutic management of asthmatic children. The aim of this study was to assess the prescribing patterns of antiasthma drugs in primary care.MethodsThis is a retrospective cohort study performed between January 2011 and December 2017 using the EGB (Echantillon Généraliste de Bénéficiaires) database, a 1/97th sample of the French national healthcare insurance system. Claims data for all individuals aged from 5 to 18 years‘ old who had received at least one antiasthma drug in the study period without any delivery in the previous 24 months and with 24 months of follow-up after first delivery, were analysed.ResultsA total of 7,680 children and adolescents (68.6% aged 5–11, 31.4% aged 12–18 years) were delivered at least one antiasthma drug (ATC code R03) during study period. The majority (66%) did not redeem another prescription in the following year (occasional users), when 18.4% redeemed prescriptions twice (low users) and 15.6% ≥3 times (high users). Most users (67%) were delivered only one class of R03 per dispensing in the first year and short-acting β2-agonists (SABAs) were the most frequently dispensed drugs. However, 33.4% of users were not prescribed SABAs. During the second year, only 27% of first-year users redeemed R03 prescriptions: 15.8% among occasional users, 35.5% of low users and 64.7% of high users. Among low and high first-year users who redeemed R03 drugs during the second year, 39.7% did not use inhaled corticoids alone or in association to LABAs.ConclusionsA high proportion of children and adolescents that used antiasthmatic drugs, even on a regular basis, were not prescribed these drugs in the long term. This finding may correspond either to the widespread use of antiasthmatic drugs in indications other than asthma or to an important undertreatment of asthmatic children and adolescents.Disclosure(s)Nothing to disclose
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Messafeur, Abdelkrim, and Nafissa Belkessam. "Epidemiological profile of asthmatic children in the wilaya of Sidi Bel Abbes: factors of asthma severity." Batna Journal of Medical Sciences (BJMS) 8, no. 1 (June 4, 2021): 24–29. http://dx.doi.org/10.48087/bjmsoa.2021.8105.

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Introduction : L’asthme sévère est un réel problème de santé publique. Le but de notre travail est de mettre en évidence les facteurs influençant la sévérité de l’asthme chez la population jeune. Matériel et méthode : Il s’agit d’une enquête transversale concernant les enfants et adolescents asthmatiques scolarisés âgés de 6 à 19 ans et résidents dans la wilaya de Sidi-Bel-Abbès entre Janvier et Mars 2016. Le questionnaire utilisé reprend les critères d'évaluation du contrôle recommandés par le Global Initiative for Asthma (GINA) 2008. Résultats et discussion : Nous avons colligé 432 enfants et adolescents asthmatiques. La prévalence de l'asthme sévère est de 12,7% et est élevée par rapport à la prévalence de 4% retrouvée dans l’étude de Benallal en 2010 menée en milieu hospitalier. Une relation significative est notée entre la sévérité de l’asthme et le mode de vie urbain de notre population et presque les deux tiers des enfants et adolescents souffrant d’asthme sévère sont exposés au tabagisme passif. Une association très significative est remarquée entre la prévalence relative de l’asthme sévère et le rang dans la fratrie d’une part et la taille de fratrie d’autre part. Dans notre étude, la répartition en fonction du statut pondéral, montre que 22% de nos patients sont en surpoids ou obèses. L’obésité est associée à une inflammation systémique qui module l’inflammation des voies respiratoires et, par conséquent, l’expression de l’asthme chez les obèses. Conclusion : La sévérité de l’asthme peut être causée, déclenchée ou influencée par de nombreux facteurs environnementaux ou liés au patient lui-même. Mots clés : asthme sévère, facteurs influençant, tabagisme passif, obésité.
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Barreto, Mario, Maria Pia Villa, Carla Olita, Susy Martella, Giovanni Ciabattoni, and Paolo Montuschi. "8-Isoprostane in Exhaled Breath Condensate and Exercise-Induced Bronchoconstriction in Asthmatic Children and Adolescents." Chest 135, no. 1 (January 2009): 66–73. http://dx.doi.org/10.1378/chest.08-0722.

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Morishita, Rosinha Yoko Matsubayaci, Maria Wany Louzada Strufaldi, and Rosana Fiorini Puccini. "Clinical evolution and nutritional status in asthmatic children and adolescents enrolled in Primary Health Care." Revista Paulista de Pediatria (English Edition) 33, no. 4 (December 2015): 387–93. http://dx.doi.org/10.1016/j.rppede.2015.08.007.

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Rodrigo, Gustavo J., and Hugo Neffen. "Systematic review on the use of omalizumab for the treatment of asthmatic children and adolescents." Pediatric Allergy and Immunology 26, no. 6 (July 1, 2015): 551–56. http://dx.doi.org/10.1111/pai.12405.

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Cevik Guner, Umran, and Ayda Celebioglu. "Impact of symptom management training among asthmatic children and adolescents on self-efficacy and disease course." Journal of Asthma 52, no. 8 (May 15, 2015): 858–65. http://dx.doi.org/10.3109/02770903.2015.1010732.

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Koh, Gerald Choon-Huat, Lynette Pei-Chi Shek, Janine Kee, Andrew Wee, Vivian Ng, and David Koh. "Saliva and Serum Eosinophil Cationic Protein in Asthmatic Children and Adolescents with and without Allergic Sensitization." Journal of Asthma 47, no. 1 (January 25, 2010): 61–65. http://dx.doi.org/10.3109/02770900903350499.

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&NA;. "A Chinese herbal decoction, Ding Chuan Tang, improves airway hyper-responsiveness in asthmatic children and adolescents,." Inpharma Weekly &NA;, no. 1549 (August 2006): 10. http://dx.doi.org/10.2165/00128413-200615490-00027.

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Botelho, C. F., C. R. De-Paula, L. A. Sá-Rocha, N. S. Jentzsch, G. S. Magalhães, L. F. C. Ramalho, E. L. G. Machado, R. C. Garcia, M. Kalil, and Machado M. G. Rodrigues. "Augmentation index (AIx), a measure of arterial stiffness, is increased in mild asthmatic children and adolescents." Physiotherapy 101 (May 2015): e1292. http://dx.doi.org/10.1016/j.physio.2015.03.1208.

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Runge, C., JT Tews, J. Lecheler, M. Horn, M. Horn, and M. Schaefer. "CS4 COST-BENEFIT ANALYSIS OF AN INTERNET-BASED PATIENT EDUCATION PROGRAMME FOR ASTHMATIC CHILDREN AND ADOLESCENTS." Value in Health 6, no. 6 (November 2003): 629. http://dx.doi.org/10.1016/s1098-3015(10)61613-0.

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Knihtilä, Hanna, Anne Kotaniemi-Syrjänen, Mika J. Mäkelä, Jonas Bondestam, Anna S. Pelkonen, and L. Pekka Malmberg. "Preschool oscillometry and lung function at adolescence in asthmatic children." Pediatric Pulmonology 50, no. 12 (March 30, 2015): 1205–13. http://dx.doi.org/10.1002/ppul.23188.

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43

Huynh, Peter, Muhammad T. Salam, Tricia Morphew, Kenny Y. C. Kwong, and Lyne Scott. "Residential Proximity to Freeways is Associated with Uncontrolled Asthma in Inner-City Hispanic Children and Adolescents." Journal of Allergy 2010 (June 13, 2010): 1–7. http://dx.doi.org/10.1155/2010/157249.

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Background. Proximity to heavy traffic has been linked to increased asthma severity. However, it is unknown whether exposure to heavy traffic is associated with the ability to maintain asthma control. Objectives. This study examines whether exposure to heavy traffic is associated with the ability to maintain asthma control in inner-city children. Methods. 756 inner-city asthmatic Hispanic children were followed for one year in a pediatric asthma management program (Breathmobile). At each scheduled visit, asthma specialist tracked patients' asthma severity and managed their asthma based on the NAEPP guidelines. The patients' residential distance from the nearest freeway was calculated based on residential address at study entry. Distance to nearest freeway was used as a surrogate marker for high exposure from traffic-related air pollutants. Results. Patients who lived near a freeway were significantly more likely to have asthma that was not well controlled (). Patients with intermittent and mild baseline severity have a two-fold increased risk of having asthma that is uncontrolled if they lived miles from a freeway (, ). Conclusion. In children with asthma, residential proximity to freeways is associated with uncontrolled asthma.
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dos Santos, Karoliny, Lílian L. Fausto, Paulo A. M. Camargos, Maicon R. Kviecinski, and Jane da Silva. "Impulse oscillometry in the assessment of asthmatic children and adolescents: from a narrative to a systematic review." Paediatric Respiratory Reviews 23 (June 2017): 61–67. http://dx.doi.org/10.1016/j.prrv.2016.09.002.

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Vila, G., C. Nollet-Clemençon, J. de Blic, M. C. Mouren-Simeoni, and P. Scheinmann. "Prevalence of DSM IV anxiety and affective disorders in a pediatric population of asthmatic children and adolescents." Journal of Affective Disorders 58, no. 3 (June 2000): 223–31. http://dx.doi.org/10.1016/s0165-0327(99)00110-x.

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46

Fonseca, Maria Teresa Mohallem, Paulo Augusto Moreira Camargos, Laura Maria Belizario Facury Lasmar, Enrico Colosimo, and Marina Mohallem Fonseca. "Risk Factors Associated with Occurrence of Clinical Deterioration After Cessation of Beclomethasone in Asthmatic Children and Adolescents." Journal of Asthma 42, no. 6 (July 1, 2005): 479–85. http://dx.doi.org/10.1081/jas-200067284.

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Mohallem Fonseca, Maria Teresa, Paulo Augusto Moreira Camargos, Laura Maria Belizario Facury Lasmar, Enrico Colosimo, and Marina Mohallem Fonseca. "Risk Factors Associated with Occurrence of Clinical Deterioration After Cessation of Beclomethasone in Asthmatic Children and Adolescents." Journal of Asthma 42, no. 6 (January 2005): 479–85. http://dx.doi.org/10.1081/jas-67284.

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48

Taglia-Ferre, Karla Delevedove, Sandra Lisboa, Luanda Dias da S. Salviano, Ana Carolina Carioca da Costa, Shandra Lisboa Monteiro, Hisbello Da Silva Campos, and Maria de Fátima Pombo March. "Is there an association between the value of forced expiratory volume in the 1st second, the Asthma Control Test and a Control Framework by Global Initiative for asthma in asthmatic children and adolescents treated with inhaled corticosteroids?" Journal of Human Growth and Development 29, no. 3 (December 12, 2019): 346–53. http://dx.doi.org/10.7322/jhgd.v29.9530.

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Objective: Evaluate the presence of association between the classification of the level of asthma control, using the method proposed by the Global Initiative for Asthma (GINA), the Asthma Control Test (ACT)/Childhood-ACT and the forced expiratory volume in the 1st second (FEV1), in asthmatic children and adolescents treated with inhaled corticosteroids, followed up at the National Institute of Women's, Children's and Adolescents' Health FernandesFigueira of the Oswaldo Cruz Foundation (IFF / FIOCRUZ). Method: A cross-sectional study was carried out with a review of the medical records of all children between 7 and 17 years of age followed up at the Asthma Outpatient Clinic and referred to the Respiratory Insertion Test (PFR) sector between March 2013 and September 2014. In the same day were applied the C-ACT/ACT questionnaires, an asthma control method proposed by the GINA and the FEV1 value in a spirometrictest. Results: From the total number of records evaluated (72), 16 children were excluded because they did not meet the required criteria for performing spirometry. The sample studied (56 children) was predominantly male (58.9%) and median age was 12 (7-17) years. It was observed an association between FEV1 and GINA values ??(p <0.01). Conclusion: The results found in this study indicate that FEV1 measurement is a useful component among the instruments for assessing clinical control of asthma by GINA.
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Scala, Cintia S. K. La, Charles K. Naspitz, and Dirceu Solé. "Adaptation and validation of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) in Brazilian asthmatic children and adolescents." Jornal de Pediatria 81, no. 1 (January 1, 2005): 54–60. http://dx.doi.org/10.2223/1283.

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Scala, Cintia S. K. La, Charles K. Naspitz, and Dirceu Solé. "Adaptation and validation of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) in Brazilian asthmatic children and adolescents." Jornal de Pediatria 81, no. 1 (February 1, 2005): 54–60. http://dx.doi.org/10.2223/jped.1283.

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