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Dissertations / Theses on the topic 'Asymmetric bond'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Judkins, Robert Andrew. "Chiral imidazolidines for asymmetric carbon-carbon bond formation." Thesis, University of Exeter, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264592.

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2

Liang, Jianglin, and 梁江林. "Ruthenium-catalyzed carbon-nitrogen bond formations." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31245729.

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3

Marcelli, Tommaso. "Cinchona-derived organocatalysts for asymmetric carbon-carbon bond formation." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/48873.

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4

Condon, Brian D. "Stereoselective bond formation via lithiation of asymmetric acyclic sulfides." Diss., Georgia Institute of Technology, 1989. http://hdl.handle.net/1853/29911.

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5

Snell, Robert Henry. "Development and application of asymmetric C-N bond formation." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:512e617a-2b01-45f3-86ae-c0cf4b874149.

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A synthetic investigation on the chemistry of cyclotryptamine derived natural products, with a particular focus on the synthesis of the trimeric-alkaloid, hodgkinsine. Methodology has been developed to tackle this complex natural product which utilises a desymmetrization approach; this strategy hinges on the development and applications of asymmetric C-N bond forming reactions. Chapter one examines elements of symmetry in natural products, looking in particular at the synthesis of compounds which contain cyclotryptamine functionality. Chapter two contains a brief review of enantioselective des

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6

Althaus, Martin. "Asymmetric C - F bond formation catalyzed by ruthenium PNNP complexes /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17673.

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7

Eno, Meredith Suzanne. "Development of Metal-Catalyzed Asymmetric Carbon-Carbon Bond Forming Reactions." Thesis, Boston College, 2017. http://hdl.handle.net/2345/bc-ir:107422.

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Thesis advisor: James P. Morken<br>This dissertation describes the development of four metal-catalyzed carbon-carbon bond forming methods. The first project presented is a palladium-catalyzed proparyl-allyl cross-coupling which proceeds via a kinetic resolution to give enantioenriched 1,5-enynes. Next the asymmetric rhodium-catalyzed hydroformylation of 1-alkenes is described. This reaction delivers synthetically useful a-chiral aldehydes in up to 98:2 er and up to 15:1 branched to linear ratio. The development of a unique nickelcatalyzed asymmetric Kumada coupling of cyclic sulfates is presen

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8

Geurts, Koen. "Copper-catalysed asymmetric carbon-carbon bond formation using Grignard reagents." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2008.

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9

Arulraj, Kaneshalingam. "Catalytic C-C bond formation and asymmetric 1,3 dipolar cycloaddition reactions." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426827.

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10

Kara, Selin, Marco Berheide, and Andreas Liese. "Reversibility of asymmetric catalyzed C–C bond formation by benzoylformate decarboxylase." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-189019.

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Benzoylformate decarboxylase (BFD) from Pseudomonas putida catalyzed the formation of 2-hydroxy-1-phenylpropanone (2-HPP), a 2-hydroxy ketone, from the kinetic resolution of rac-benzoin in the presence of acetaldehyde. The formation rate of 2-HPP via kinetic resolution of benzoin was 700-fold lower compared to the formation via direct carboligation of benzaldehyde and acetaldehyde. Further investigations revealed that BFD not only accepts (R)-benzoin but also 2-HPP as the substrate. A typical Michaelis–Menten type kinetics was observed starting from enantiopure (S)- or (R)-2-HPP. The formation

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11

Kara, Selin, Marco Berheide, and Andreas Liese. "Reversibility of asymmetric catalyzed C–C bond formation by benzoylformate decarboxylase." Royal Society of Chemistry, 2015. https://tud.qucosa.de/id/qucosa%3A29057.

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Benzoylformate decarboxylase (BFD) from Pseudomonas putida catalyzed the formation of 2-hydroxy-1-phenylpropanone (2-HPP), a 2-hydroxy ketone, from the kinetic resolution of rac-benzoin in the presence of acetaldehyde. The formation rate of 2-HPP via kinetic resolution of benzoin was 700-fold lower compared to the formation via direct carboligation of benzaldehyde and acetaldehyde. Further investigations revealed that BFD not only accepts (R)-benzoin but also 2-HPP as the substrate. A typical Michaelis–Menten type kinetics was observed starting from enantiopure (S)- or (R)-2-HPP. The formation

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12

Maksymowicz, Rebecca Marie. "Catalytic asymmetric carbon-carbon bond formation using alkenes as alkylmetal equivalents." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:e8066937-de5d-4f8b-b2c6-1a4bbd72169b.

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The development of new methods for carbon-carbon bond formation is a challenging topic at the heart of organic chemistry. Over the past ten years a number of methods for the catalytic asymmetric 1,4-addition of organometallic reagents such as Grignard, organozinc and organoaluminium reagents have been reported. However these reagents suffer from many limitations, including the need for cryogenic temperatures, which prevent their widespread use. Here we have developed a new asymmetric method: the copper-catalysed enantioselective 1,4-addition of alkylzirconium compounds, generated in situM/em>,

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13

Fukata, Yukihiro. "Studies on Asymmetric Hetero-Michael Addition Utilizing Various Modes of Organocatalytic Activation." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215551.

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14

Hayashi, Motoko. "Studies on Asymmetric Reduction of a Carbon-Carbon Double Bond with Biocatalyst." 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/150020.

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15

Coll, Serrahima Mª Mercè. "Sugar-based ligand libraries for asymmetric reductions and c-c bond forming reactions." Doctoral thesis, Universitat Rovira i Virgili, 2011. http://hdl.handle.net/10803/65638.

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Un dels principals mètodes per a sintetitzar productes enantiomericament purs és la catàlisi asimètrica utilitzant compostos organometàl•lics quirals. En aquesta estrategia, el disseny i preparació de lligands quirals és molt important. En aquest context, nosaltres hem desenvolupat nous lligands quirals per diverses reaccions de catàlisi asimètrica. Concretament ens hem centrat en: (a) L’aplicació d’una llibreria de lligands fosfit-fosforoamidit i difosforoamidit derivats de carbohidrats en la hidrogenació de olefines proquirals. Aquests lligands han donat excel•lents enantioselectivitats

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16

Brozek, Laura. "Asymmetric Carbon-Carbon Bond Formation Via 3,3'-Reductive Elimination of Allyl Palladium Complexes." Thesis, Boston College, 2011. http://hdl.handle.net/2345/2454.

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Thesis advisor: James P. Morken<br>This dissertation describes the development of two enantioselective methods of carbon-carbon bond formation. Chapter one discusses the development of an enantioselective Pd(0)-catalyzed conjugate addition of allylboronic acid pinacol ester to α,β-unsaturated methylidene ketones. Utilizing the same rationale for regio- and enantiocontrol as in the related enantioselective conjugate allylation of arylidene ketones, this method addresses the gap in technology by expanding the scope of the reaction to include alkyl-substituted enones. Chapter two exami

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17

Rousseaux, Sophie. "Palladium-Catalyzed C(sp2)-C(sp3) Bond Formation." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23058.

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Palladium-catalyzed reactions for carbon-carbon bond formation have had a significant impact on the field of organic chemistry in recent decades. Illustrative is the 2010 Nobel Prize, awarded for “palladium-catalyzed cross couplings in organic synthesis”, and the numerous applications of these transformations in industrial settings. This thesis describes recent developments in C(sp2)-C(sp3) bond formation, focusing on alkane arylation reactions and arylative dearomatization transformations. In the first part, our contributions to the development of intramolecular C(sp3)-H arylation reactions

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18

Eymur, Serkan. "Development Of Novel Catalytic Methodologies For Carboncarbon Bond Construction." Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12615303/index.pdf.

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Addition reactions of nucleophilic trifluoromethyltrimethylsilane (CF3TMS) to acyl phosphonates were investigated. Various acyl phosphonates reacted readily with CF3TMS in the presence of K2CO3 to give 1-alkyl-2,2,2-trifluoro-1-trimethylsilyloxyethylphosphonate in 70-90% yields. When benzoyl phosphonates were used as starting material, after addition of CF3, the formed alcoholate undergoes phosphonatephosphate rearrangement to form the acyl anion, followed by elimination of F- to give 1-aryldifluoroethenyl phosphates in 87-97% yields. The proline&ndash<br>thiourea host&ndash<br>guest complex

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19

Hunt, Nicola Anne. "Uses of zirconium, titanium and copper in some asymmetric carbon : carbon bond forming reactions." Thesis, University of Warwick, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369428.

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20

Biswas, Souvagya. "Asymmetric Catalysis of Carbon-Carbon Bond Forming Reactions: Use of a Sustainable Feedstock Ethylene." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1449830785.

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21

Ichikawa, Saki. "Copper-catalyzed carbon-heteroatom bond formations : asymmetric hydroamination and continuous-flow aromatic Finkelstein reaction." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122852.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The studies presented in this dissertation are regarding the development of new methods for copper-catalyzed carbon-heteroatom bond formations, including asymmetric hydroamination and continuous-flow aromatic Finkelstein reaction. The first part of this dissertation focuses on the development of copper-catalyzed asymmetric hydroamination reactions to access various classes of enantioenriched amines. This includes the developmen

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22

Hawkins, Joel Michael. "Three new CÌ²₂ symmetric chiral auxiliaries for metal mediated asymmetric reactions : studies in asymmetric carbon-hydrogen, carbon-nitrogen, and carbon-oxygen bond formation." Thesis, Massachusetts Institute of Technology, 1986. http://hdl.handle.net/1721.1/15198.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1986.<br>MICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCE<br>Bibliography: leaves 110-116.<br>by Joel Michael Hawkins.<br>Ph.D.

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23

Aota, Yusuke. "Development of New Methodologies for the Asymmetric Synthesis of Chiral Sulfoximines via C-S Bond Formation." Kyoto University, 2020. http://hdl.handle.net/2433/253103.

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24

Inokuma, Tsubasa. "Development of Novel Hydrogen-Bond Donor Catalysts Bearing Amino or Hydroxy Group for Asymmetric Synthesis." 京都大学 (Kyoto University), 2011. http://hdl.handle.net/2433/152053.

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25

Slater, Natasha H. "The synthesis and functionalisation of chiral cleft molecules and their application as asymmetric hydrogen bond organocatalysts." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/16855.

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26

Doda, Kanae. "Development of Asymmetric Carbon-Carbon Bond-Forming Reactions Using Novel Catalysis of Chiral Quaternary Ammonium Fluorides." 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/147843.

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27

Kumar, C. R. "Asymmetric synthesis of bioactive molecules and catalysis by novel palladium complexes in C-C bond formation." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2007. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2600.

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28

Huang, Juan. "The relationship between oil prices and stock/bond market: a sectoral analysis." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/398066.

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Economics<br>Ph.D.<br>While numerous studies have investigated the impact of oil prices on the stock market, Chapter 2 is the first to examine the association between corporate bond yields and oil returns. We examine the association between oil-returns and corporate bond yields of four major U.S. industrial and financial sectors (including thirteen sub-sectors). Chapter 3 examines the reaction of stock markets in the U.K. and the Netherlands to a major composite event in the oil industry – the merger of the Royal Dutch Shell (RDSA) and the BG Group (BRGYY) on April 8, 2015, and the subsequent

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29

Frölander, Anders. "Impact of Secondary Interactions in Asymmetric Catalysis." Doctoral thesis, KTH, Organisk kemi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4380.

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This thesis deals with secondary interactions in asymmetric catalysis and their impact on the outcome of catalytic reactions. The first part revolves around the metal-catalyzed asymmetric allylic alkylation reaction and how interactions within the catalyst affect the stereochemistry. An OH–Pd hydrogen bond in Pd(0)–π-olefin complexes of hydroxy-containing oxazoline ligands was identified by density functional theory computations and helped to rationalize the contrasting results obtained employing hydroxy- and methoxy-containing ligands in the catalytic reaction. This type of hydrogen bond was

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30

Mata, Campaña Yvette Angela. "Screening of Modular Carbohydrate Ligand Libraries in Asymmetric Metal-catalyzed C-C and C-X Bond Formation Reactions." Doctoral thesis, Universitat Rovira i Virgili, 2007. http://hdl.handle.net/10803/9090.

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En els últims anys, la creixent demanda de compostos enantiomèricament purs (fàrmacs, agroquímics...) ha impulsat el desenvolupament de la catàlisi asimètrica, sobretot emprant compostos organometàl·lics quirals com a catalitzadors. En aquest context, la síntesi de nous lligands quirals és essencial per descobrir bons sistemes catalítics en catàlisis asimètrica. Els sucres són una font important de lligands per l'elevada disponibilitat i baix preu. A més, són compostos altament funcionalitzats amb centres esterogènics. Això permet la síntesi de sèries sistemàtiques de lligands amb l'obje

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31

Kim, Jaewoo. "Asymmetric timely loss recognition, private debt markets, and underinvestment| Evidence from the collapse of the junk bond market." Thesis, The University of Iowa, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3566668.

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<p> This paper uses the collapse of the junk bond market in the early 1990s as a natural experiment to examine the effect of asymmetric timely loss recognition (ATLR) on speculative-grade (SPG) firms' access to private debt markets and underinvestment. For a sample of 450 firm-years over the period 1988-1991, I find that SPG firms that recognize economic losses in a timelier fashion experience a smaller reduction in debt financing and investment from the pre- to post-collapse period relative to SPG firms that recognize economic losses in a less timely fashion. I also document that the effect o

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32

Ford, David Dearborn. "The Role of Catalyst-Catalyst Interactions in Asymmetric Catalysis with (salen)Co(III) Complexes and H-Bond Donors." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11154.

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In asymmetric catalysis, interactions between multiple molecules of catalyst can be important for achieving high catalyst activity and stereoselectivity. In Chapter 1 of this thesis, we introduce catalyst-catalyst interactions in the context of the classic Kagan nonlinear effect (NLE) experiment, and present examples of the strengths and drawbacks of the NLE experiment. For the remainder of the thesis, we explore catalyst-catalyst interactions in the context of two different reactions. First, in Chapter 2, we apply a combination of reaction kinetics and computational chemistry to a reaction th

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33

Dietrich-Campbell, Bruce John. "Two topics in Finance: 1. Welfare aspects of an asymmetric information rational expectations model : 2. Bond option pricing, empirical evidence." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25565.

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In part 1 of this study I examine several models of competitive markets in which a group of uninformed traders uses the equilibrium price of a traded asset as an indirect source of information known to a group of informed traders. Four different models are compared in two homogeneous information cases plus one asymmetric information case, revealing a) an allocative efficiency benefit resulting from the opportunity to trade current consumption for future consumption, b) a 'dealer' benefit accruing to traders who are able to observe and act on demand fluctuations not apparent to other traders, c

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34

Wieting, Joshua Merlin. "Silanediol-Catalyzed Stereoselective Functionalization of Heterocycles." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1448891366.

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35

Mazuela, Aragón Javier. "Design and screening of biaryl phosphite-based ligand libraries for asymmetric reduction and c-c and c-x bond forming reactions." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/96665.

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Durant els últims anys, els compostos fosfit han demostrat ser lligands eficients en diverses reaccions catalitzades por metalls de transició. En aquest context, hem desemvolupat diverses lligandoteques fosfit per la seva aplicació en reaccions per obtenit productes enantiomericament purs. Més concretament hem estudiat: (a) La síntesis i aplicació de 9 lligandoteques fosfit-nitrogen en l’hidrogenació d’olefines mínimament funcionalizades catalitzada per iridi i les reaccions de substitució al•lílica i Heck catalitzades per pal•ladi. Aquests lligands s’han dissenyat mitjançant variacions siste

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36

Kennington, Stuart. "The development of new, direct and asymmetric Ni(II) catalysed carbon-carbon bond forming reactions and their application to total synthesis." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/670342.

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This thesis focuses on the search for new methodologies for the direct, stereoselective and catalytic formation of carbon-carbon bonds through the formation of chiral nickel(II) enolate species and the application of such methods to the synthesis of natural products. The project starts with the stereocontrol coming from chiral auxiliaries, developed first by Evans and then later by Crimmins and Nagao, following the previous experience and expertise of the research group. These auxiliaries have proved to be a reliable and high yielding option to afford excellent levels of stereocontrol in vario

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37

Kurlemann, Nils. "Evaluation of C-C-bond coupling enzymes as reversibly immobilised biocatalysts and for the application in a coupled asymmetric alkene oxidation." Berlin mbv, 2008. http://d-nb.info/990627527/04.

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38

Afewerki, Samson. "Development of catalytic enantioselective C-C bond-forming and cascade transformations by merging homogeneous or heterogeneous transition metal catalysis with asymmetric aminocatalysis." Doctoral thesis, Mittuniversitetet, Avdelningen för naturvetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-23605.

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Chiral molecules play a central role in our daily life and in nature, for instance the different enantiomers or diastereomers of a chiral molecule may show completely different biological activity. For this reason, it is a vital goal for synthetic chemists to design selective and efficient methodologies that allow the synthesis of the desired enantiomer. In this context, it is highly important that the concept of green chemistry is considered while designing new approaches that eventually will provide more environmental and sustainable chemical synthesis.The aim of this thesis is to develop th

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39

Grounds, Helen. "Investigations into the use of C-H activation for aryl-aryl bond formation : the synthesis of novel chiral ferrocene ligands for asymmetric catalysis." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478994.

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40

Ghotekar, G. S. "Asymmetric synthesis of biologically important compounds and development of synthetically useful C-C and C-O bond forming reactions via transition metal free conditions." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2019. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/5855.

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41

Baldwin, Andrea Michelle. "Synthesis and Functionalization of Heterocycles via Non-Covalent Catalysis." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1467277822.

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42

Prasad, P. K. "Asymmetric synthesis of bioactive molecules and development of synthetic methodologies involving C-C, C-O and C-N bond formation via Cu(I) and iodine catalysis." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2015. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2034.

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43

Magre, Rosich Marc. "Design of tailor-made chiral ligand libraries for C-X bond forming reactions. Study of the key intermediates by NMR and DFT." Doctoral thesis, Universitat Rovira i Virgili, 2016. http://hdl.handle.net/10803/396081.

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El desenvolupament de metodologies per a l’obtenció de compostos enantiomèricament purs ha incrementat en les últimes dècades, ja que aquests productes quirals tenen un gran impacte en la societat actual perquè són la base de fàrmacs, insecticides, perfums i productes naturals, entre altres. La catàlisi asimètrica en la que el catalitzador està basat en un centre metàl·lic i un lligand coordinat al metall ha estat la tècnica més emprada en els últims anys. Aquests complexos organometàl·lics ofereixen propietats molt concretes, com per exemple la seva gran selectivitat en els processos enantios

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44

Brown, Adam Ross. "I. Engaging Cationic Intermediates in Asymmetric Catalysis: Enantioselective Reactions of Carbenium Ions and N,N-Dialkyliminium Ions II. Enantioselective Catalysis of the Cope-Type Hydroamination by H-Bond Donors." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11009.

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The research described here explores the ability of dual H-bond donor catalysts to induce asymmetry in a variety of synthetically useful transformations that proceed via diverse reactive intermediates. In Chapters 1-3, we investigate ureas and thioureas as anion-binding catalysts for asymmetric reactions that proceeed via cationic intermediates with little precedent as electrophiles in asymmetric catalysis. Chapter 4 details our application of H-bond donor catalysis to the Cope-type hydroamination. Chapter 1 describes the development of an asymmetric aldehyde alkylation catalyzed by a bifunc

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45

Borràs, Noguera Carlota. "Sustainable and cost-effective development of chiral metal-catalysts for C-H and C-X bond forming reactions." Doctoral thesis, Universitat Rovira i Virgili, 2018. http://hdl.handle.net/10803/664741.

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L’obtenció de compostos enantiomèricament purs ha esdevingut una necessitat que ha conduit a un important progrés en la catàlisi asimètrica, principalment usant compostos organometàl•lics quirals. Entre les diferents estratègies en l’optimització dels catal•litzadors per aconseguir elevades selectivitats i activitats, el disseny i correcta selecció de lligands quirals, modificant-ne les seves propietats és fonamental i la més utilitzada. Que un lligand sigui fàcil de sintetitzar a partir de compostos de partida accessibles i que aquests lligands siguin estables i fàcils de manipular, tenen un

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46

Biosca, Brull Maria. "Fitting the catalysts for effective enantioselective C-X bond forming reactions. Theoretically guided ligand design and mechanistic investigations." Doctoral thesis, Universitat Rovira i Virgili, 2018. http://hdl.handle.net/10803/665121.

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La creixent demanda de compostos enantiomèricament purs, ha incrementat l’interès pel desenvolupament de metodologies per l’obtenció d'aquests compostos. Entre elles, la catàlisi asimètrica és la tècnica més emprada. En aquesta metodologia, l'elecció lligand quiral és clau per l'obtenció de elevades activitats i enantioselectivitats. En aquest context, aquesta tesis és centra en la síntesis de diferents famílies de lligands quirals altament modulars a partir de productes de partida d'elevada disponibilitat. Més concretament, s’han sintetitzat diverses famílies de lligands heterodadors P-oxazol

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47

Margalef, Pallarès Jèssica. "Screening of modular and readily available ligand libraries for C-X (X=H, C, N and O) bond forming reactions. The use of DFT studies for catalysts optimization." Doctoral thesis, Universitat Rovira i Virgili, 2016. http://hdl.handle.net/10803/386578.

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El creixent interès per a l’obtenció de compostos enantiomèricament purs, ha conduït a un important desenvolupament de la catàlisi asimètrica. En aquest context, aquesta tesis és centra en la síntesis de vàries famílies de lligands quirals altament modulars a partir de compostos de fàcil disponibilitat. Concretament, s'ha treballat en la síntesis de lligands fosfit-tioèter, fosfit-piridina, fosfit-triazola i lligands hidroaximida i tioamida. Tots ells tenen en comú que són sòlids, estables i per tant de fàcil manipulació. Aquests lligands s'han aplicat en la hidrogenació d’olefines funcionalit

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48

Maggiotti, Virginie. "Direct biocatalytic asymmetric aldol reactions." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275468.

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49

Lecavalier, Pierre. "Polymer-bound chiral auxiliaries in asymmetric hydride reductions." Thesis, University of Ottawa (Canada), 1991. http://hdl.handle.net/10393/7946.

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The preparation of chiral amino alcohols which can be used in the asymmetric reduction of acetophenone is described. These amino alcohols were complexed with lithium aluminum hydride (LAH) and achiral agents in various ratios and once treated with acetophenone, afforded l-phenylethanol in poor to moderate optical yields (20%-70%). These chiral molecules were grafted to 1% crosslinked polystyrene and the polymeric hydride complexes yielded l-phenylethanol in lower optical yield than the model compounds. A detailed study of this behavior using l-ephedrine as the chiral auxiliary allowed us to co

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50

Villa, Marcos Bárbara. "Chiral amines via asymmetric reduction of imino bonds." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569128.

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Amines, in particular α-chiral amines, are highly valuable products and key intermediates of great importance in chemical synthesis. Therefore, developing new methods for the synthesis of optically pure amines is an important task in organic chemistry. Chapter 1 presents a general introduction to recent development in the asymmetric reduction of imino bonds, focusing on the metal- catalysed asymmetric hydrogenation of imines. This introduction will be followed by the presentation of several methodologies for the synthesis of amines, with an emphasis on chiral amines. Chapter 2 describes the sy

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