Log in

Relevant bibliographies by topics / Asymmetric synthesis. Lactones / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Asymmetric synthesis. Lactones.

Dissertations / Theses on the topic 'Asymmetric synthesis. Lactones'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 28 dissertations / theses for your research on the topic 'Asymmetric synthesis. Lactones.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Wright, Edward Andrew. "π-Allyltricarbonyliron lactones in asymmetric synthesis". Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621938.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Edwards, M. I. "Asymmetric synthesis of lignan lactones from meso compounds." Thesis, Swansea University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636768.

Full text

Abstract:

The purpose of this research was to form (2S, 3R)-2,3bis(3,4-dimethoxybenzyl) butyrolactone. A brief review of the main classes of lignans, their biosynthesis, biological activity and clinical utility is given in the first chapter. The main chemical synthesis routes to such compounds are also provided covering the six most commonly used routes including the Stobbe condensation. An overview of the use of <I>meso</I> compounds for the production of chiral synthons and use of the '<I>meso</I> <I>trick</I>' to enhance yields during chiral induction to <I>meso</I> substrates are discussed in chapte

APA, Harvard, Vancouver, ISO, and other styles

3

Harsh, Philip R. "Applications of asymmetric allylation reactions towards natural product synthesis." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=6029.

Full text

Abstract:

Thesis (M.S.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains vi, 78 p. : ill. Includes abstract. Includes bibliographical references (p. 37-38).

APA, Harvard, Vancouver, ISO, and other styles

4

Oh, Seongho. "Optimization and extensions of the nucleophile catalyzed aldol-lactonization (NCAL) process for bicyclic beta-lactone synthesis: applications to piperidine, pyrrolidine, and gamma-lactam-fused beta-lactones." Texas A&M University, 2003. http://hdl.handle.net/1969.1/3961.

Full text

Abstract:

The intramolecular nucleophile catalyzed aldol-lactonization (NCAL) process was optimized successfully. A variety of C9-acylated cinchona alkaloids were synthesized and used for NCAL reactions with non-activated aldehydes. New pyridinium salts, derivatives of MukaiyamaÂs reagent, led to marked improvements in efficiency for the catalytic, asymmetric NCAL process while maintaining high enantioselectivity. Larger scale versions of the catalytic, asymmetric NCAL reaction were also developed allowing practical access to chiral bicyclic b-lactones. As an extension of the intramolecular NCAL proces

APA, Harvard, Vancouver, ISO, and other styles

5

Soltani, Omid. "Photochemical preparations of salicylate/resorcylate esters/amides asymmetric synthesis of SCH 351448 /." Access to abstract only; dissertation is embargoed until after 5/16/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=168.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Rabiller, Christine. "Nouvelles voies de synthèse de lactones bioactives." Nancy 1, 1994. http://www.theses.fr/1994NAN10339.

Full text

Abstract:

La synthèse enantiospécifique de lactones bioactives, inhibitrices d'une part de l'hmgcoa réductase, et d'autre part des lipases pancréatiques a été entreprise. Dans une première partie, l'accès facile et rapide à des composés de structure didesoxy-2-4-hexopyranose, chiron clé pour la synthèse d'inhibiteurs de la biosynthèse du cholestérol, a été réalisé par transformation stéréospécifique du 1,6-anhydro-beta-d-glucopyranose obtenu par pyrolyse dans de bonnes conditions qui ont été mises au point dans ce travail. Dans la deuxième partie, l'application des méthodes de création de liaison carbon

APA, Harvard, Vancouver, ISO, and other styles

7

Olabisi, Ayodele O. Wimalasena Kandatege. "The chemistry of L-ascorbic acid derivatives in the asymmetric synthesis of C2- and C3-substituted aldono-gamma-lactones." Diss., Access through your commercial service, 2005. http://il.proquest.com/products_umi/dissertations/.

Full text

Abstract:

Thesis (Ph.D.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistry.<br>"August 2005." Title from PDF title page (viewed on February 6, 2007). Thesis adviser: Kandatege Wimalasena. Includes bibliographic references (leaves 144-163).

APA, Harvard, Vancouver, ISO, and other styles

8

Otto, Andreas. "Ringtransformationen an chiralena-Alkylidenlactonen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 1999. http://dx.doi.org/10.18452/14473.

Full text

Abstract:

Ziel dieser Arbeit ist die Synthese neuer optisch aktiver Hydroxyalkylheterocyclen durch Ringtransformationen von chiralen -Alkylidenlactonen. Hierzu wurden letztere gezielten Additionen von Binucleophilen, 1,3-dipolaren Cycloadditionen, Cupratadditionen und Epoxidierungsreaktionen unterworfen. Die erhaltenen Produkte konnten durch weitere gezielte Folgereaktionen, Spaltungen oder Reaktionen mit Nucleophilen zu interessanten enantiomerenreinen Hydroxyalkylheterocyclen umgesetzt werden. Eine Deutung der acyclischen Seitendifferenzierung gelang mit Hilfe des antiperiplanaren Effektes und des ins

APA, Harvard, Vancouver, ISO, and other styles

9

Hamze, Khalil. "Baeyer-Villiger monooxygenases d'Acinetobacter : réactions biocatalysées et dédoublements cinétiques dynamiques." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4311/document.

Full text

Abstract:

L'oxydation de Baeyer-Villiger (BV) par voie enzymatique est une méthode efficace pour obtenir de lactones sous forme énantiomériquement pure. Les Baeyer-Villiger Monooxygénases (BVMO) sont ainsi capables d'oxyder de nombreux substrats avec une stéréospécificité remarquable.Nous avons recherché de nouvelles enzymes dans le génome de deux souches appartenant au genre Acinetobacter, A. baylyi ADP1 et A. baumannii AYE. Six gènes ont été clonés dans E. coli. Leur profil de substrat a été étudié en utilisant des cellules entières de ce microorganisme recombinant comme biocatalyseur. Quatre enzymes

APA, Harvard, Vancouver, ISO, and other styles

10

David, Hamon Catherine. "Synthese asymetrique de lactones : application a la serie des acides meviniques, inhibiteurs de la biosynthese du cholesterol." Poitiers, 1988. http://www.theses.fr/1988POIT2203.

Full text

Abstract:

La compactine et la mevinoline sont des inhibiteurs de l'hmg-coa reductase, enzyme qui transforme l'hmg-coa en acide mevalonique dans une des premieres etapes de la biosynthese du cholesterol. Ces inhibiteurs sont caracterises par un squelette decalinique lie a un systeme lactonique dont la presence est indispensable a l'activite biologique. La preparation d'analogues necessite de disposer d'un synthon chiral qui peut etre obtenu a partir d'un sucre de la serie d. Plusieurs methodes de desoxygenation en positions 2 et 4 a partir de sucres divers (glucose, mannose, galactose) ont ete etudiees.

APA, Harvard, Vancouver, ISO, and other styles

11

Aybey, Asuman. "Synthesis Of Chiral Lactones Via The Baeyer Villiger Oxidation Of Cyclic Aromatic Acetoxy Ketones Novel Annulation Reactions Of 2-propynyl-1,3-dicarbonyl Compounds To Form Pyrroles Addition Of Acyl Phosphonates To Diethyl Cyanophosphonate (depc)." Phd thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12610293/index.pdf.

Full text

Abstract:

Chiral Baeyer-Villiger (BV) oxidation of cyclic ketones allows rapid access to asymmetric lactones as valuable intermediates in organic chemistry and frequently encountered precursors in enantioselective synthesis. In the first part, BV oxidation of functionalized ketones, especially cyclic &amp<br>#61537<br>-hydroxy and acetoxy ketones is described which could be a straightforward route to the &amp<br>#61537<br>-hydroxy lactones and &amp<br>#61537<br>-hydroxyalkanoic acid derivatives. The &amp<br>#61537<br>-acetoxylation of indanone, tetralone and chromanone derivatives by using Mn(OAc)3 fol

APA, Harvard, Vancouver, ISO, and other styles

12

Hollowood, Christopher John. "π-allyltricarbonyliron lactone complexes in asymmetric synthesis". Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620305.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Cox, Liam Robert. "π-Allyltricarbonyliron lactone complexes in asymmetric synthesis". Thesis, University of Cambridge, 1997. https://www.repository.cam.ac.uk/handle/1810/275281.

Full text

Abstract:

The thesis is divided into seven chapters. The first reviews methods of preparation of tricarbonyliron complexes of organic molecules, with particular emphasis on their synthesis in enantiomerically enriched form. Chapter two describes the use of these complexes in controlling the stereochemical outcome of reactions carried out on functional groups appended to the organic ligand. The third chapter describes methods of releasing the organic ligand in a stereoselective manner. Chapter four outlines an example of 1,5-induction of chirality in the diastereoselective allylation of ketone groups app

APA, Harvard, Vancouver, ISO, and other styles

14

Fernandez, Anne-Marie. "Préparation de γ-butyrolactones γ-alkylées optiquement pures à partir de l'acide L-tartrique. Application à la synthèse totale de la L-bioptérine". Rouen, 1996. http://www.theses.fr/1996ROUES025.

Full text

Abstract:

Une nouvelle méthode pour la préparation de gamma-butyrolactones optiquement pures est proposée. Une stratégie de synthèse donnant accès à deux types de chirons carbonylés (cétones et aldéhyde) a permis le développement de deux réactions hautement stéréosélectives créant ainsi un troisième centre stéréogénique : la réduction des cétones, (2R, 3R)-2,3-dipivaloxy-4-oxo alcanoates de méthyle par le borohydure de sodium dans le méthanol mène aux alcools correspondants (4R), avec des ee>98%, précurseurs des (2R,3S,4R)-2,3-dipivaloxy-4-alkylbutyrolactones. L'addition d'organomagnésiens sur l'aldéhyd

APA, Harvard, Vancouver, ISO, and other styles

15

Harter, Jürgen. "π-allyltricarbonyliron lactone complexes : versatile tools for asymmetric synthesis". Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603808.

Full text

Abstract:

The opening chapter will give an introductory review of the chemistry of p-allyltricarbonyliron lactone complexes, in which their preparation and behaviour towards a variety of reagents is described. The utility of those complexes in organic synthesis to date will be outlined, with particular focus on controlling the stereochemical outcome of reactions carried out on functional groups appended to the organic ligand. In a further chapter, a synthetic route towards the total synthesis of the neutral product decarestrictine D will be described. Model studies will highlight the potential feasibili

APA, Harvard, Vancouver, ISO, and other styles

16

Hutt, Jean. "Synthese d'analogues de la vitamine d::(3) : synthese chirale de composes polyhydroxyles." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13326.

Full text

Abstract:

La transformation de la cfarvone en quatre diastereoisomeres precurseurs du cycle a des dihydrovitamines et dihydrotachysterols est decrite dans la premiere partie. Par couplage d'un acetylure derive des cycles c/d de la vitamine d::(3) avec la cetone precurseur du cycle a, puis sa formation du systeme dienique a l'aide de titane a basse valence nous avons obtenu des dihydrotachysterols majoritairement. D'un autre cote, l'utilisation de sulfoxydes optiquement actifs dans l'intention de creer des centres hydroxyles chiraux et son application a la synthese du fragment polyhydroxyle de l'amphoter

APA, Harvard, Vancouver, ISO, and other styles

17

Chemla, Philippe. "Reactions diastereospecifiques de dienones fer-tricarbonyle : applications a la synthese d'alcools fonctionnalises optiquement purs." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13049.

Full text

Abstract:

La methode de synthese utilisee permet d'acceder avec de bons rendements, a des composes de haute purete optique et de configuration donnee: alpha et gamma aldols et une delta -lactone fonctionnalisee en position 5. Des hydrocarbures optiquement actifs dont le centre asymetrique est eloigne de toute fonction, ont egalement ete synthetises par cette voie

APA, Harvard, Vancouver, ISO, and other styles

18

Pale, Patrick. "Synthese et reactivite d'epoxyalcools acetyleniques chiraux : application a la synthese de cyclopropanes et d'heterocycles fonctionnalises." Reims, 1988. http://www.theses.fr/1988REIMS012.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

TALAGA, PATRICE. "Synthese et activite biologique de tolerogenes potentiels." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR13101.

Full text

Abstract:

Essais d'induction de tolerance aux haptenes de type alpha-methylene gamma butyrolactones (amgbl) responsables de nombreuses allergies de contact. Synthese de differents tolerogenes potentiels hydrosolubles de la forme lactone-derives lysinyl et lactone-derives cysteinyl. Etude de l'induction asymetrique observee lors de l'addition de michael d'un dipeptide (voc-cys-ala-ome) a differentes amgbl. Observation d'un parallelisme entre cette induction asymetrique et l'enantioselectivite de la reponse immunitaire dans le phenomene de l'allergie croisee

APA, Harvard, Vancouver, ISO, and other styles

20

Azevedo, Mariangela Burgos Martins de. "Synthèse énantiosélective de (gamma)-butyrolactones : ()-méthylénolactocine, (-)-acide protolichestérinique, (-)-blastmycinolactol, (+)-blastmycinone, (-)-NFX-2 et (+)-antimycinone." Université Joseph Fourier (Grenoble ; 1971-2015), 1995. http://www.theses.fr/1995GRE10116.

Full text

Abstract:

La cycloaddition du dichlorocetene avec des éthers d'enols chiraux conduit à des cyclobutanones fonctionnalisées avec une diastéréosélectivité élevée. Cette réaction est basée sur la différenciation des faces de la double liaison de l'oléfine chirale. Des intermédiaires de pureté enantiomerique élevée, comme les gamma-butyrolactones, sont obtenus à partir des cycloadduits. Au cours de ce travail, nous avons effectué les premières synthèses enantioselectives des produits naturels suivants: la (moins)-methylenolactocine et l'(moins)-acide protolichesterinique. Ces alpha-méthylène-gamma-butyrolac

APA, Harvard, Vancouver, ISO, and other styles

21

PETIT, YVES. "Synthese d'hydroxy-2 esters enantiomeriquement purs a partir d'amino-2 acide : etude stereochimique de l'addition 1,4 d'organometalliques sur des systemes insatures-2,3 hydroxy-4." Paris 6, 1987. http://www.theses.fr/1987PA066578.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Davoren, Jennifer Elizabeth. "Studies towards the asymmetric total synthesis of solandelactone oxylipins: the total synthesis of solandelactone E." Thesis, 2006. http://hdl.handle.net/2152/2709.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Morris, Kay A. "Applications of B-Lactones: Utility of Spiroepoxy-B-Lactones and Development of a Double Diastereoselective Nucleophile Catalyzed, Aldol-Lactonization Process Leading to !-Lactone Fused Carbocycles and Tetrahydrofurans." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8405.

Full text

Abstract:

Natural products continue to inspire synthetic chemists to develop novel methodologies to provide efficient and expedient syntheses of the target molecules. Haterumalide NA aroused our interest and prompted development of four differing methodologies. Three of the strategies pursued involved use of B-lactone scaffolds as intermediates. Extensions of the nucleophile catalyzed, aldol-lactonization (NCAL) reaction were also pursued and targeted toward alternative natural product targets. The reactivity of the unexpectedly stable strained spirocycle, spiroepoxy-B- lactone, was explored. Spiroepoxy

APA, Harvard, Vancouver, ISO, and other styles

24

Dornan, Peter. "Transition Metal Catalysis: Construction of Chiral Lactones, Ketones, Sulfoxides and 6-deoxyerythronolide B." Thesis, 2013. http://hdl.handle.net/1807/35807.

Full text

Abstract:

The products of organic synthesis affect countless aspects of our everyday lives, from our medicines to our fuels, plastics and more. The discovery of new methods for organic synthesis is of paramount importance if we are to find greener and more efficient ways to synthesize commodity and fine chemicals, and lower the impact of the chemical industry on our environment. The aim of my doctoral thesis is to discover fundamentally new enantioselective transformations using transition metal catalysis, which can be applied to the synthesis of pharmaceutical agents, natural products or other fine che

APA, Harvard, Vancouver, ISO, and other styles

25

Khan, Hasan. "Asymmetric Synthesis of Lactones and Lactams: Rhodium Catalysis in the Hydroacylation of Ketones and the Hydrogenation of Cyclic Dehydropeptides." Thesis, 2013. http://hdl.handle.net/1807/35862.

Full text

Abstract:

Organic synthesis allows access complex materials in the context of fine chemicals, pharmaceuticals, and natural products, but many contemporary methods are wasteful – the focus is on the target rather than the process. Stoichiometric reagents, protecting groups, and multi-step processes are often involved to synthesize moieties such as chiral lactones and lactams, which are prevalent in biologically-relevant molecules like antibiotics (for example, the macrolides, typified by erythromycin) and cyclic peptides (such as cyclosporin and gramicidin). We have developed a rhodium-catalyzed lactoniz

APA, Harvard, Vancouver, ISO, and other styles

26

Olabisi, Ayodele O. "The chemistry of L-ascorbic acid derivatives in the asymmetric synthesis of C2- and C3-substituted aldono-gamma-lactones." Diss., 2005. http://hdl.handle.net/10057/540.

Full text

Abstract:

The antioxidant and redox properties of L-ascorbic acid are closely associated with the electron rich 2, 3-enediol moiety of the molecule and therefore selective functionalization of the 2- and 3-OH groups is essential for the detailed structure-activity studies. Reactions of 5- and 6-OH protected ascorbic acid with electrophilic reagents exclusively produce the corresponding 3-O-alkylated products under mild basic conditions due to the high nucleophilicity of the C-3-OH. Based on the density functional theory (B3LYP) electron density calculations, a novel and general method was devised for th

APA, Harvard, Vancouver, ISO, and other styles

27

Jeong, Won Boo [Verfasser]. "Asymmetric methodologies for the construction of 5,7,5- and 6,6,6-tricyclic sesquiterpene lactones towards the synthesis of Arglabin / vorgelegt von Won Boo Jeong." 2007. http://d-nb.info/985286229/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Hu, Chu Chen, and 胡聚成. "Intramolecular Cyclization of Tungsten Alkynyl Complexes and Bicyclic Lactones Asymmetry Synthesis." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/94071570455283060763.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!