Relevant bibliographies by topics / AT901

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Academic literature on the topic 'AT901'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 February 2022

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Journal articles on the topic "AT901"

1

Theissen, Nikolas Alexander, Monica Katherine Gonzalez, Asier Barrios, and Andreas Archenti. "Quasi-Static Compliance Calibration of Serial Articulated Industrial Manipulators." International Journal of Automation Technology 15, no. 5 (September 5, 2021): 590–98. http://dx.doi.org/10.20965/ijat.2021.p0590.

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This article presents a procedure for the quasi-static compliance calibration of serial articulated industrial manipulators. Quasi-static compliance refers to the apparent stiffness displayed by manipulators at low-velocity movements, i.e., from 50 to 250 mm/s. The novelty of the quasi-static compliance calibration procedure lies in the measurement phase, in which the quasi-static deflections of the manipulator’s end effector are measured under movement along a circular trajectory. The quasi-static stiffness might be a more applicable model parameter, i.e., representing the actual manipulator more accurately, for manipulators at low-velocity movements. This indicates that the quasi-static robot model may yield more accurate estimates for the trajectory optimization compared with static stiffness in the implementation phase. This study compares the static and apparent quasi-static compliance. The static deflections were measured at discretized static configurations along circular trajectories, whereas the quasi-static deflections were measured under circular motion along the same trajectories. Loads of different magnitudes were induced using the Loaded Double Ball Bar. The static and quasi-static displacements were measured using a linear variable differential transformer embedded in the Loaded Double Ball Bar and a Leica AT901 laser tracker. These measurement procedures are implemented in a case study on a large serial articulated industrial manipulator in five different positions of its workspace. This study shows that the measured quasi-static deflections are bigger than the measured static deflections. This, in turn, indicates a significant difference between the static and apparent quasi-static compliance. Finally, the implementation of the model parameters to improve the accuracy of robots and the challenges in realizing cost-efficient compliance calibration are discussed.
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Peng, You-Wel, and Dominic Man-Kit lam. "Organization and development of horizontal cells in the goldfish retina, I: The use of monoclonal antibody AT101." Visual Neuroscience 6, no. 4 (April 1991): 357–70. http://dx.doi.org/10.1017/s0952523800006581.

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AbstractWe have produced and characterized a monoclonal antibody, AT101, which selectively labels both viable and formaldehyde-fixed horizontal cell axon terminals, but not their somas or axons, of the goldfish (Carassius auratus) retina. The antigen recognized by AT101 appears to be a cell surface glycoprotein with a molecular weight of about 35,000 Daltons, and is present exclusively or predominantly in nervous tissues of all vertebrate species examined. We have used AT101 as a probe to analyze immunocytochemically the organization of horizontal cell axon terminals (HCATs) in the adult goldfish retina, and the emergence and maturation of these terminals during retinal development. Because of continued growth at the retinal margin in adult goldfish, there is a peripheral-to-central gradient in the age of cells, with the most mature in the center and the youngest in the periphery. In the center and near periphery of the adult retina, HCATs have a fusiform morphology and form a dense network in the middle and proximal part of the inner nuclear layer. In the far peripheral retina, the axon terminals appear round or ellipsoid. The retina closest to the retinal margin is devoid of AT101 staining, indicating that either HCATs are absent or the antigen recognized by AT101 is not present on HCATs at this stage. A similar sequence of changes in staining pattern is seen during development. Although AT101 staining can first be demonstrated in the larval retina at 1 month after hatching, it appears mostly as punctate structures. At a later stage, there are round or ellipsoid structures that resemble in morphology and location (in the inner nuclear layer) those found in the far peripheral adult retina. Double-labeling experiments with AT101 and antiserum against tubulin also indicate that AT101 labels the HCATs when they first appear during development. These data suggest that the emergence and maturation of HCAT is a late event in retinal development.
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Caylioglu, Deniz, Rieke Johanna Meyer, Dana Hellmold, Carolin Kubelt, Michael Synowitz, and Janka Held-Feindt. "Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche." International Journal of Molecular Sciences 22, no. 7 (March 30, 2021): 3606. http://dx.doi.org/10.3390/ijms22073606.

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Glioblastoma (GBM) is a barely treatable disease due to its profound chemoresistance. A distinct inter- and intratumoral heterogeneity reflected by specialized microenvironmental niches and different tumor cell subpopulations allows GBMs to evade therapy regimens. Thus, there is an urgent need to develop alternative treatment strategies. A promising candidate for the treatment of GBMs is AT101, the R(-) enantiomer of gossypol. The present study evaluates the effects of AT101, alone or in combination with temozolomide (TMZ), in a microenvironmental glioma stem cell niche model of two GBM cell lines (U251MG and U87MG). AT101 was found to induce strong cytotoxic effects on U251MG and U87MG stem-like cells in comparison to the respective native cells. Moreover, a higher sensitivity against treatment with AT101 was observed upon incubation of native cells with a stem-like cell-conditioned medium. This higher sensitivity was reflected by a specific inhibitory influence on the p-p42/44 signaling pathway. Further, the expression of CXCR7 and the interleukin-6 receptor was significantly regulated upon these stimulatory conditions. Since tumor stem-like cells are known to mediate the development of tumor recurrences and were observed to strongly respond to the AT101 treatment, this might represent a promising approach to prevent the development of GBM recurrences.
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Prada, Carlos E., Januario E. Castro, Dayong Zhai, Shinichi Kitada, John C. Reed, and Thomas J. Kipps. "R-(−)-Gossypol (AT101) Binds to Bcl-2 Family Proteins and Induces Apoptosis in CLL." Blood 106, no. 11 (November 16, 2005): 2978. http://dx.doi.org/10.1182/blood.v106.11.2978.2978.

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Abstract Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of monoclonal B cells in the blood, secondary lymphoid tissues, and marrow. The leukemia cells primarily are arrested in the G0/G1 phase of the cell cycle and appear resistant to programmed cell death. Several anti-apoptotic proteins are over expressed in CLL and this correlates with resistance to treatment, disease progression and overall poor prognosis. Proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-X(L), Bcl-2, and Mcl-1, are overexpressed in many cancers including CLL and contribute to tumour initiation, progression and resistance to therapy. Mcl-1 is of particular interest because this molecule appears to be regulated by Nurse-like Cells and other stromal cells that promote survival of CLL cells in vitro and very likely also in vivo. These proteins enhance the resistance of CLL cells to spontaneous and/or drug-induced apoptosis primarily by interacting with, and antagonizing the activity of mitochondria membrane pro-apoptotic proteins such as Bax and Bak. The protein-protein interaction of Bcl-2 family members is critical for their activity, and these interactions are governed by binding to the BH3 domain. Racemic gossypol is found in cotton seeds and has been studied as a cytotoxic agent in cancer cell lines and in clinical studies in patients with a large variety of cancers. The antitumor activity of racemic gossypol appears to reside principally in the R-(−)-enantiomer (AT101), with reduced activity observed for the S-(+)-enantiomer. AT101 is an antagonist of the BH3-binding groove of the Bcl-2 family of proteins that can inhibit the interactions of these proteins with pro-apoptotic molecules. We examined whether AT101 could induce apoptosis in Chronic Lymphocytic Leukemia (CLL) and its ability to bind in vitro anti-apoptotic molecules from the Bcl-2 family. Using a Fluorescence Polarization Assay (FPA) we studied the competitive binding affinity of AT101 to Bcl-2 family member proteins. We observed that both, racemic gossypol and AT101 had comparable affinity for Bck-2, Bcl-B, Bfl-1 with EC50=0.6 to 10 μM range. AT101 had a stronger binding affinity to Bcl-X(L) (EC50=0.998 μM vs. 3.084 μM for racemic gossypol), and to Mcl-1 (EC50= 0.52μM vs. 1.07μM for racemic gossypol). CLL cells were incubated with AT101 for 48 hrs at different concentrations. We observed that leukemia cells were induced to undergo apoptosis in a time and dose dependent manner and that this effect was independent of ZAP-70 expression or IgVH gene mutational status (IC50= 2μM). Cells undergoing apoptosis showed PARP-1 cleavage and upregulation of pro-apoptotic molecules such as Bid, p53, as well as downregulation of Mcl-1. These results indicate that AT101 has stronger pan-specific binding affinity for Bcl-2 family proteins than racemic gossypol, in particular to Mcl-1 and Bcl-X(L), and that this compound induces apoptosis in CLL B cells independently of ZAP-70 expression or IgVH gene mutational status. Because of these encouraging results a clinical trial using AT101 in CLL patients with high-risk features is currently open at our institution.
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Ibrahim, N. B., Ftema W. Aldbea, and Mustaffa Hj Abdullah. "Effects of Annealing Temperature on Structure and Magnetic Properties ofTbxY3−xFe5O12(x=0.2and 0.4) Thin Films." Journal of Nanomaterials 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/154192.

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Terbium-substituted yttrium iron garnet (TbxY3−xFe5O12(x=0.2and 0.4)) thin films have been successfully prepared by a sol-gel method followed by spin-coating process. The annealing of the films was performed at different temperatures like 700, 800, and900°Cand found that the films annealed at900°Cturned out to be crystallized into a pure garnet phase. All of the films were bearing grains of nanometer in size. Increasing the annealing temperature gave extra energy to the grains causing to be agglomerates. The lattice contraction occurred as the grain’s sizes were decreased due to the decrease of Fe2+formation. The magnetic measurements show that all of the films are soft magnetic materials with low saturation magnetization values. The hysteresis loops of the films which were annealed at900°Cwere found angular in shape similar to the single crystal-like YIG film.
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Dvořáček, Filip. "LABORATORY TESTING OF LEICA AT401 LASER TRACKER." Acta Polytechnica 56, no. 2 (April 30, 2016): 88. http://dx.doi.org/10.14311/ap.2016.56.0088.

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<p>This paper describes laboratory tests on a Leica AT401laser tracker. As the newer Leica AT402 model also uses the same firmware package, most of the results should also be valid for this device. First, we present the instrument’s firmware errors and the software used for testing. The ASME B89.4.19-2006 standard for testing laser trackers is briefly presented. The warm-up effect of the instrument is inspected with respect to both angle measurement and distance measurement. The absolute distance meter (ADM) is compared with a laboratory interferometer on a 30-meter long rail and also on a bench with automated movement of the carriage of the reflector. A time series of measurements for determining the additive constant is evaluated. A simple test of the stability of the distance measurement in field conditions is introduced. Most of the tests were carried out at the Research Institute of Geodesy, Topography and Cartography (RIGTC) and at the Faculty of Civil Engineering (FCE) of the Czech Technical University in Prague (CTU).</p>
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Dvořáček, Filip. "System Software Testing of Laser Tracker Leica AT401." Geoinformatics FCE CTU 13 (December 21, 2014): 49–57. http://dx.doi.org/10.14311/gi.13.6.

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The article introduces a group of instruments called laser trackers and specificallyfocuses on one of them - Leica AT401. At the Research Institute of Geodesy, To-pography and Cartography the instrument has been tested both in laboratory andoutdoor conditions. Several significant errors in the instrument’s system softwarehave been found, mostly due to the creation of user-programmed controlling appli-cation called ATControl. The errors are related to a selection, a computation andan evaluation procedure of the refractive index of air. Finally, notes of the newmeasurement modes of Leica AT40x are given and a range of distance measure-ment is discussed.
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Mallick, David J., and Alan Eastman. "AT101 [(-)-Gossypol] Selectively Inhibits MCL1 and Sensitizes Carcinoma to BH3 Mimetics by Inducing and Stabilizing NOXA." Cancers 12, no. 8 (August 15, 2020): 2298. http://dx.doi.org/10.3390/cancers12082298.

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Anti-apoptotic BCL2 proteins are important targets for cancer therapy as cancers depend on their activity for survival. Direct inhibitors of MCL1 have entered clinical trials, although their efficacy may be limited by toxicity. An alternative approach may be to induce the pro-apoptotic protein NOXA which selectively inhibits MCL1 in cells. Many compounds originally proposed as inhibitors of the BCL2 family were subsequently found to induce the pro-apoptotic protein NOXA through the unfolded protein response. In the present study, we compared various putative BH3 mimetics across a panel of carcinoma cell lines and measured expression of NOXA protein and mRNA, as well as the kinetics of NOXA induction. We found that AT101 [(-)-gossypol] induces high levels of NOXA in carcinoma cell lines yet cells survive. When combined with an appropriate BCL2 or BCL-XL inhibitor, NOXA-dependent sensitization occurs. NOXA protein continues to accumulate for many hours after AT101 is removed, providing a window for administering these combinations. As MCL1 promotes drug resistance and overall survival, we propose that NOXA induction is an alternative therapeutic strategy to target MCL1 and either kill cancer cells that are dependent on MCL1 or sensitize cancer cells to other BCL2 inhibitors.
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Flak, Dorota K., Vivian Adamski, Grzegorz Nowaczyk, Kosma Szutkowski, Michael Synowitz, Stefan Jurga, and Janka Held-Feindt. "AT101-Loaded Cubosomes as an Alternative for Improved Glioblastoma Therapy." International Journal of Nanomedicine Volume 15 (October 2020): 7415–31. http://dx.doi.org/10.2147/ijn.s265061.

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10

Dvořáček, Filip. "ATControl Software for Leica AT40x Laser Trackers." Geoinformatics FCE CTU 14, no. 2 (December 8, 2015): 9–20. http://dx.doi.org/10.14311/gi.14.2.2.

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The paper describes a software called ATControl which is based on the Matworks Matlab high-level programming language. This software is under constant development by the author in order to collect geospatial data by measuring with the absolute laser tracker Leica AT40x (AT401, AT402). Commercially available software solutions are shortly reviewed and the reasons for developing the new controlling application are discussed. Advantages of ATControl concerning metrological traceability of measured distances are stated. Key functional features of software are introduced.
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Dissertations / Theses on the topic "AT901"

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Kozáček, Peter. "Softwarové rozhraní pro uživatelské aplikace laser trackeru." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2015. http://www.nusl.cz/ntk/nusl-231747.

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For assembly of product machine is necessary to evaluate a geometric accuracy of individual functional parts of the machine. This process is very demanding and time consuming. One of the reasons of mentioned problems is the lack of software (adaptation) for measuring of the accuracy of geometrical precision. This theses (diploma work) focuses at facilitating the development and creation of own application based on customer requirements and for measuring geometric accuracy with the Laser Tracker AT901 from Leica company. The aim is to create a basic application suitable for measurement of geometric accuracy, which would speed up this process, would be user-friendly, simple and open for further expansion.
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Engström, Adam. "Strömsparande arkitektur för inbyggnadslinux." Thesis, Linköpings universitet, Programvara och system, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-110120.

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The objective of this work was to evaluate and implement a number of energy saving functions for a specific embedded system. The functions were then grouped into a number of energy levels with known properties in terms of functionality, energy consumption, and transition time between the levels. The embedded system consisted of an AT91 ARM9 processor, GSM/GPRS modem, display, Ethernet and other peripheral units. Some energy saving methods that were considered were suspend to RAM, suspend to disk, frequency scaling, and methods for saving energy in the modem, Ethernet, USB and display backlight. The functions were grouped into levels and an interface was specified for controlling the energy level. It proved possible to get known properties within the defined energy levels, even though the paritioning of functions into these levels proved to be sub-optimal in a typical application usage scenario because it was designed for mainly energy consumption, not usage. The final result is a number of energy saving functions grouped into levels, which are controllable via an application interface. Each of the levels have a known energy consumption in both loaded and un-loaded mode.
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Al-Faisali, Nihad. "An Open Source Platform for Controlling the MANOI AT01 Humanoid Robot and Estimating its Center of Mass." University of Dayton / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1399035167.

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Conference papers on the topic "AT901"

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Tao, Yongchao, Wencheng Xiang, and Xianghu Wu. "Simulation and Realization of AT91 Microcontroller Emulator." In 2017 International Seminar on Artificial Intelligence, Networking and Information Technology (ANIT 2017). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/anit-17.2018.9.

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Dvoracek, Filip. "LONG RANGE DISTANCE MEASUREMENT WITH LEICA AT401 LASER TRACKER." In 16th International Multidisciplinary Scientific GeoConference SGEM2016. Stef92 Technology, 2016. http://dx.doi.org/10.5593/sgem2016/b22/s09.051.

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Dvoracek, Filip. "CALIBRATION OF FIELD LENGTH BASELINES USING LEICA AT401 LASER TRACKER." In 17th International Multidisciplinary Scientific GeoConference SGEM2017. Stef92 Technology, 2017. http://dx.doi.org/10.5593/sgem2017/22/s09.018.

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Guth, S. Lee. "ATD01 model for color appearances, color differences, and chromatic adaptation." In 9th Congress of the International Color Association, edited by Robert Chung and Allan Rodrigues. SPIE, 2002. http://dx.doi.org/10.1117/12.464744.

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