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Journal articles on the topic 'Atherosclerosis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Napieralski, Rudolf, Ernst Wagner, Harry Gebhard, et al. "Alternation of histone and DNA methylation in human atherosclerotic carotid plaques." Thrombosis and Haemostasis 114, no. 08 (2015): 390–402. http://dx.doi.org/10.1160/th14-10-0852.

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SummaryLittle is known about epigenetics and its possible role in atherosclerosis. We here analysed histone and DNA methylation and the expression of corresponding methyltransferases in early and advanced human atherosclerotic carotid lesions in comparison to healthy carotid arteries. Western Blotting was performed on carotid plaques from our biobank with early (n=60) or advanced (n=60) stages of atherosclerosis and healthy carotid arteries (n=12) to analyse di-methylation patterns of histone H3 at positions K4, K9 and K27. In atherosclerotic lesions, di-methylation of H3K4 was unaltered and t

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2

Li, Junxi, Xinying Fu, Renyi Yang, and Wei Zhang. "Atherosclerosis Vascular Endothelial Secretion Dysfunction and Smooth Muscle Cell Proliferation." Journal of Healthcare Engineering 2022 (March 9, 2022): 1–13. http://dx.doi.org/10.1155/2022/9271879.

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Atherosclerosis is a chronic inflammatory disease of the arterial wall and the main cause of cardiovascular disease and cerebrovascular disease. In recent years, the mortality rate of atherosclerotic diseases has become higher and higher. This article aims to study the dysregulation of atherosclerotic vascular endothelial secretion and smooth muscle cell proliferation, and put forward and practice the pathological research of atherosclerotic disease. This article describes in detail atherosclerosis, endothelial dysfunction, and smooth muscle cell proliferation, and studies the causes of athero

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Mohmand-Borkowski, Adam, Dareus O. Conover, and Tomasz Rozmyslowicz. "Fibroblast Activation Protein Compared with Other Markers of Activated Smooth Muscle Cells, Extracellular Matrix Turnover and Inflammation in a Mouse Model of Atherosclerosis." Metabolites 15, no. 4 (2025): 243. https://doi.org/10.3390/metabo15040243.

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Background: Fibroblast activation protein (FAP) is a cell surface glycoprotein expressed by myofibroblastic cells in areas of active tissue remodeling, such as wound healing, fibrosis, and certain chronic inflammatory lesions. As FAP is uniquely present in chronic inflammatory lesions and has an important role in extracellular matrix (ECM) turnover, it appears to have all the characteristics necessary for involvement in atherosclerosis and atherosclerotic plaque rupture and has become a potential target in the treatment of myocardial infarction. Methods: To further understand the role of FAP,

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Moatassem, Salah Amer*1 Randa Abdel WahabReda Mabrouk2 Omar Hussein Omar3 Tarekkhairy Abdel Dayem4 Samia Ahmed Abdul-Rahman5& Basma Kamel Abdel Aziz6. "FRAILTY AND SUBCLINICAL ATHEROSCLEROSIS." Indian Journal of Medical Research and Pharmaceutical Sciences 4, no. 3 (2017): 1–9. https://doi.org/10.5281/zenodo.343751.

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<strong>Background:</strong> Frailty as well as atherosclerotic diseases are commonly prevalent among elderly subjects and usually share both complex pathway and risk factors. Hence it was important to study if there is an association between frailty and risk factors of atherosclerosisat its early stages (subclinical atherosclerosis) using the Ankle Brachial Index (ABI), carotid intima media thickness (CIMT) and Abdominal Aortic Diameter (AAD) as markers of subclinical atherosclerosis. <strong>Material and Methods:</strong> A cross-sectional study conducted on 90 elderly participants (60-year-

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Šačić, Dalila, Sofija Glumac, and Sanja Radojević-Škodrić. "The significance of inflammation in pathogenesis, diagnosis and treatment of atherosclerosis." Medicinski podmladak 76, no. 1 (2025): 42–47. https://doi.org/10.5937/mp76-48564.

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Atherosclerosis is a chronic disease whose progression starts from birth. The basic substrate of an atherosclerotic lesion is the deposition of lipids in the intima of the blood vessel, which results in gradual narrowing and impaired blood flow through the tissues. The clinical manifestations of the atherosclerotic process are numerous and they depend on the degree of narrowing and the speed of the stenosis. The most common clinical manifestations are the result of rupture of the atherosclerotic plaque, which activates the process of thrombogenesis and leads to the development of blockage of b

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Xia, Mingcan, Kangkang Yang, Nadia Guerra, et al. "NKG2D/ligands-mediated immune activation promotes atherosclerosis (142.7)." Journal of Immunology 184, no. 1_Supplement (2010): 142.7. http://dx.doi.org/10.4049/jimmunol.184.supp.142.7.

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Abstract Atherosclerosis, a chronic vascular disease, is characterized by deposition of fatty substances and accumulation of immune cells in susceptible regions of arteries. Increasing evidence show that abnormal metabolic conditions, such as dyslipdemia and diabetes, induce immune cell activation and inflammation, which play crucial roles in progression of atherosclerosis. However, molecular linkers of metabolic disorder, immune activation and atherosclerosis are not well understood. Here we report that ligands for NKG2D, an immune-activating receptor, were upregulated in multiple tissues and

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Konstantinova, E. V., A. A. Bogdanova, A. A. Sagatelyan, A. I. Kovaikin, E. S. Pershina, and M. Yu Gilyarov. "Features of atherosclerosis in carotid and coronary arteries." Meditsinskiy sovet = Medical Council, no. 14 (October 18, 2021): 44–53. http://dx.doi.org/10.21518/2079-701x-2021-14-44-53.

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Atherothrombosis is a leading cause of myocardial infarction and ischemic atherothrombotic stroke. It represents a stage of atherosclerosis which is a pathologic process throughout the circulatory system. However, atherosclerosis has specific development characteristics in different vascular beds. Multiple factors contribute to atherosclerosis formation and progression such as genetic factors, vessel hemodynamics, and vessel anatomy. A better understanding of differences in vessels would improve prevention and treatment of atherosclerosis and its complication. In this article we review feature

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Juricic, Stefan, Jovana Klac, Sinisa Stojkovic, et al. "Molecular and Pathophysiological Mechanisms Leading to Ischemic Heart Disease in Patients with Diabetes Mellitus." International Journal of Molecular Sciences 26, no. 9 (2025): 3924. https://doi.org/10.3390/ijms26093924.

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Coronary atherosclerosis in patients with diabetes mellitus is the most significant pathophysiological mechanism responsible for ischemic heart disease. Atherosclerosis in diabetes is premature, more diffuse, and more progressive, and it affects more coronary blood vessels compared to non-diabetics. Atherosclerosis begins with endothelial dysfunction, continues with the formation of fatty streaks in the intima of coronary arteries, and ends with the appearance of an atherosclerotic plaque that expands centrifugally and remodels the coronary artery. If the atherosclerotic plaque is injured, a t

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9

Pakzad, Bahram, Elham Rajae, Saeid Shahrabi, et al. "T-Cell Molecular Modulation Responses in Atherosclerosis Anergy." Laboratory Medicine 51, no. 6 (2020): 557–65. http://dx.doi.org/10.1093/labmed/lmaa003.

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Abstract Atherosclerosis continues to be a major cause of death in patients with cardiovascular diseases. The cooperative role of immunity has been recently considered in atherosclerotic plaque inflammation, especially adaptive immune response by T cells. In this review, we examine the possible role of T cells in atherosclerosis-mediated inflammation and conceivable therapeutic strategies that can ameliorate complications of atherosclerosis. The cytokines secreted by T-lymphocyte subsets, different pathophysiological profiles of microRNAs (miRs), and the growth factor/receptor axis have divers

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Li, Yang, Yi Feng, Genshan Ma, Chengxing Shen, and Naifeng Liu. "Coronary tortuosity is negatively correlated with coronary atherosclerosis." Journal of International Medical Research 46, no. 12 (2018): 5205–9. http://dx.doi.org/10.1177/0300060518804723.

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Objective The impact of coronary tortuosity on coronary atherosclerosis remains unclear. This study was performed to determine to the relationship between coronary tortuosity and the presence of coronary atherosclerosis. Methods Tortuosity and the presence of coronary atherosclerosis in the main coronary arteries were evaluated. The coronary artery was divided into non-tortuous and tortuous segments. The incidence of coronary atherosclerosis between the two segments was compared. Results The prevalence of coronary atherosclerotic stenosis was significantly lower in the tortuous than non-tortuo

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11

Raman Parajuli, Sudhir, Bishwonath Yadav, Prahlad Karki, Paricha Upadhyaya, and Shivendra Jha. "An Autopsy Study of Atherosclerotic Changes in Coronary Arteries at B.P. Koirala Institute of Health Sciences." Annapurna Journal of Health Sciences 1, no. 1 (2021): 4–8. http://dx.doi.org/10.52910/ajhs.5.

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Introduction: Atherosclerosis is a giant killer and the incidence of atherosclerosis in coronary arteries is rapidly increasing. The study was designed to assess the atherosclerotic lesions in coronary artery and to correlate the risk factors related to prevalence of atherosclerosis. Methods: Heart from 100 medico legal autopsy cases ranging between ages 15 to 35 years which came to BPKIHS Dharan were taken for this study and processed for coronary arteries using conventional technique. They were then studied,and grading was done based on Modified American Heart Association (AHA) classif

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Yang, Yang, Lixia Yang, Xing Liang, and Guofu Zhu. "MicroRNA-155 Promotes Atherosclerosis Inflammation via Targeting SOCS1." Cellular Physiology and Biochemistry 36, no. 4 (2015): 1371–81. http://dx.doi.org/10.1159/000430303.

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Aims: Accumulating evidence suggests that atherosclerotic progression depends on persistent and chronic inflammation in the arterial walls. MicroRNA-155 is reportedly involved in cardiovascular disease and has been implicated as a pro-inflammation regulator. Although some researchers have focused on microRNA-155 as an atherosclerosis regulator, the mechanisms by which microRNA-155 functions as a putative pro-atherosclerosis microRNA are largely unknown. This study aims to analyze microRNA-155's effects on atherosclerotic inflammation and to explore its mechanism. Methods: MicroRNA-155's effect

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Peycheva, Marieta, Tanya Deneva, Dora Zlatareva, Tina Zdravkova, Lubomir Chervenkov, and Zdrvaka Harizanova. "Image and Laboratory Aspects of Carotid Atherosclerosis." Experimental and Applied Biomedical Research (EABR) 24, no. 2 (2023): 135–44. http://dx.doi.org/10.2478/sjecr-2022-0047.

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Abstract Carotid atherosclerosis is a main risk factor for ischemic stroke. Plaque instability is determined by the morphological characteristics of the plaque and can be characterized by immunological biomarkers. The study aimed to examine the connection between serum levels of hs-CRP, fibrinogen, ICAM-1, VCAM-1 and carotid atherosclerosis and the different types of atherosclerotic plaques imaged by ultrasound and magnetic resonance. The study involved 120 patients with carotid atherosclerosis and 33 patients without carotid atherosclerosis. Blood samples were collected to analyze the serum l

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Tanaka, Toru, Naoto Sasaki, and Yoshiyuki Rikitake. "Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis." Journal of Clinical Medicine 10, no. 24 (2021): 5907. http://dx.doi.org/10.3390/jcm10245907.

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Atherosclerotic diseases, including ischemic heart disease and stroke, are a main cause of mortality worldwide. Chronic vascular inflammation via immune dysregulation is critically involved in the pathogenesis of atherosclerosis. Accumulating evidence suggests that regulatory T cells (Tregs), responsible for maintaining immunological tolerance and suppressing excessive immune responses, play an important role in preventing the development and progression of atherosclerosis through the regulation of pathogenic immunoinflammatory responses. Several strategies to prevent and treat atherosclerosis

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15

Zhou, Zhi-Xiang, Zhong Ren, Bin-Jie Yan, et al. "The Role of Ubiquitin E3 Ligase in Atherosclerosis." Current Medicinal Chemistry 28, no. 1 (2020): 152–68. http://dx.doi.org/10.2174/0929867327666200306124418.

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: Atherosclerosis is a chronic inflammatory vascular disease. Atherosclerotic cardiovascular disease is the main cause of death in both developed and developing countries. Many pathophysiological factors, including abnormal cholesterol metabolism, vascular inflammatory response, endothelial dysfunction and vascular smooth muscle cell proliferation and apoptosis, contribute to the development of atherosclerosis and the molecular mechanisms underlying the development of atherosclerosis are not fully understood. Ubiquitination is a multistep post-translational protein modification that participat

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Schäfer, Sarah, and Alma Zernecke. "CD8+ T Cells in Atherosclerosis." Cells 10, no. 1 (2020): 37. http://dx.doi.org/10.3390/cells10010037.

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Atherosclerotic lesions are populated by cells of the innate and adaptive immune system, including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse and human atherosclerosis and revealed activated, cytotoxic, and possibly dysfunctional and exhausted cell phenotypes. In mouse models of atherosclerosis, antibody-mediated depletion of CD8+ T cells ameliorates atherosclerosis. CD8+ T cells control monopoiesis and macrophage accumulation in early atherosclerosis. In addition, CD8+ T cells exert cytotoxic functions in atherosclerotic plaques and contribute to macroph

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17

Iannuzzi, Arcangelo, Paolo Rubba, Marco Gentile, et al. "Carotid Atherosclerosis, Ultrasound and Lipoproteins." Biomedicines 9, no. 5 (2021): 521. http://dx.doi.org/10.3390/biomedicines9050521.

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Carotid artery plaques are considered a measure of atherosclerosis and are associated with an increased risk of atherosclerotic cardiovascular disease, particularly ischemic strokes. Monitoring of patients with an elevated risk of stroke is critical in developing better prevention strategies. Non-invasive imaging allows us to directly see atherosclerosis in vessels and many features that are related to plaque vulnerability. A large body of evidence has demonstrated a strong correlation between some lipid parameters and carotid atherosclerosis. In this article, we review the relationship betwee

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Kozhanova, T. V., E. V. Neudakhin, S. S. Zhilina, et al. "THE GENETIC SUSCEPTIBILITY TO ATHEROSCLEROSIS." Russian Archives of Internal Medicine 8, no. 6 (2018): 407–17. http://dx.doi.org/10.20514/2226-67042018-8-6-407-417.

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Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Atherosclerosis is the main cause of death and disability in developed countries, while in developing countries the incidence of this pathology is growing rapidly. Advances in techniques of molecular genetics have revealed that genetic polymorphisms significantly influence susceptibility to atherosclerotic vascular diseases. A large number of candidate genes, genetic polymorphisms and susceptibility loci associated with atherosclerotic diseases have been identified in

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Tanashyan, Marine M., Andrey S. Mazur, Anton A. Raskurazhev, et al. "Intracranial atherosclerosis: structure, clinical aspects and risk factors." Annals of Clinical and Experimental Neurology 19, no. 1 (2025): 5–13. https://doi.org/10.17816/acen.1266.

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Introduction. Atherosclerosis is a complex pathophysiological process with a wide range of clinical manifestations. Active research is underway to determine the prevalence of intracranial atherosclerosis across different ethnic groups, the role of modifiable and non-modifiable risk factors in its pathogenesis, and the advances in diagnostic algorithms for patients with extra-/intracranial atherosclerosis. The aim was to evaluate manifestations of intracranial atherosclerosis (patterns of intracranial artery lesions, including pathomorphological findings) and identify potential associations bet

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20

Herbers, Oliver, Carsten Höltke, Marco Virgilio Usai, et al. "Influence of Atherosclerosis-Associated Risk Factors on Expression of Endothelin Receptors in Advanced Atherosclerosis." International Journal of Molecular Sciences 26, no. 5 (2025): 2310. https://doi.org/10.3390/ijms26052310.

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Endothelin-1 (ET-1) levels are altered in atherosclerosis, while the roles of the endothelin receptors ETAR and ETBR during the pathogenesis of atherosclerosis remain unclear. Therefore, the focus of this study was to clarify how endothelin receptors are expressed in advanced human atherosclerotic plaques and how this is related to atherosclerotic risk factors. Ex vivo expression analysis was performed by quantitative real-time PCR (qRT-PCR) of 98 atherosclerotic plaques and controls that were obtained from adult patients undergoing vascular surgery. Correlation analyses of atherosclerosis-pro

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Henein, Michael Y., Sergio Vancheri, Gani Bajraktari, and Federico Vancheri. "Coronary Atherosclerosis Imaging." Diagnostics 10, no. 2 (2020): 65. http://dx.doi.org/10.3390/diagnostics10020065.

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Identifying patients at increased risk of coronary artery disease, before the atherosclerotic complications become clinically evident, is the aim of cardiovascular prevention. Imaging techniques provide direct assessment of coronary atherosclerotic burden and pathological characteristics of atherosclerotic lesions which may predict the progression of disease. Atherosclerosis imaging has been traditionally based on the evaluation of coronary luminal narrowing and stenosis. However, the degree of arterial obstruction is a poor predictor of subsequent acute events. More recent techniques focus on

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Hartman, Robin J. G., Katie Owsiany, Lijiang Ma, et al. "Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching." Circulation 143, no. 7 (2021): 713–26. http://dx.doi.org/10.1161/circulationaha.120.051231.

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Background: Although sex differences in coronary artery disease are widely accepted with women developing more stable atherosclerosis than men, the underlying pathobiology of such differences remains largely unknown. In coronary artery disease, recent integrative systems biological studies have inferred gene regulatory networks (GRNs). Within these GRNs, key driver genes have shown great promise but have thus far been unidentified in women. Methods: We generated sex-specific GRNs of the atherosclerotic arterial wall in 160 women and age-matched men in the STARNET study (Stockholm-Tartu Atheros

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Nehler, M. R., L. M. Taylor, and J. M. Porter. "Homocysteinemia as a Risk Factor for Atherosclerosis: A Review." Cardiovascular Surgery 5, no. 6 (1997): 559–67. http://dx.doi.org/10.1177/096721099700500603.

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In industrialized nations, the leading cause of death and disability is atherosclerosis. Despite a widespread research effort spanning decades, there remains no clearly defined cause or cure for this disease that directly or indirectly affects the lives of almost all individuals in the western world. Autopsy findings show atherosclerosis to some degree in nearly all aged people, suggesting it should be regarded as a normal aging process as well as a disease. Any investigation of atherosclerosis etiology therefore requires a distinction between atherosclerosis normally observed with aging, and

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Yu, Qun, Yilin Zhang, Wenyun Zeng, et al. "Buyang Huanwu Decoction Alleviates Atherosclerosis by Regulating gut Microbiome and Metabolites in Apolipoprotein E-deficient Mice fed with High-fat Diet." Chinese Journal of Physiology 67, no. 2 (2024): 88–102. http://dx.doi.org/10.4103/ejpi.ejpi-d-23-00031.

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Abstract The traditional Chinese herbal prescription Buyang Huanwu decoction (BHD), effectively treats atherosclerosis. However, the mechanism of BHD in atherosclerosis remains unclear. We aimed to determine whether BHD could alleviate atherosclerosis by altering the microbiome-associated metabolic changes in atherosclerotic mice. An atherosclerotic model was established in apolipoprotein E-deficient mice fed high-fat diet, and BHD was administered through gavage for 12 weeks at 8.4 g/kg/d and 16.8 g/kg/d. The atherosclerotic plaque size, composition, serum lipid profile, and inflammatory cyto

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Piollet, Marie, Florentina Porsch, Giuseppe Rizzo, et al. "TREM2 protects from atherosclerosis by limiting necrotic core formation." Nature Cardiovascular Research 3, no. 3 (2024): 269–82. http://dx.doi.org/10.1038/s44161-024-00429-9.

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AbstractAtherosclerosis is a chronic disease of the vascular wall driven by lipid accumulation and inflammation in the intimal layer of arteries, and its main complications—myocardial infarction and stroke—are the leading cause of mortality worldwide1,2. Recent studies have identified triggering receptor expressed on myeloid cells 2 (TREM2), a lipid-sensing receptor regulating myeloid cell functions3, to be highly expressed in macrophage foam cells in experimental and human atherosclerosis4. However, the role of TREM2 in atherosclerosis is not fully known. Here we show that hematopoietic or gl

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OMAR, EFFAT, NURUL AISHAH MUHAMMAD, NURUL AIN ABU BAKAR, and HAPIZAH NAWAWI. "PREVENTIVE EFFECTS OF TOCOTRIENOL-ENRICHED MIXED FRACTION ON PLAQUE FORMATION AND STABILITY IN EARLY AND ESTABLISHED ATHEROSCLEROSIS." Malaysian Applied Biology 51, no. 1 (2022): 21–28. http://dx.doi.org/10.55230/mabjournal.v51i1.1995.

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Atherosclerosis is the underlying pathology for cardiovascular disease. The preventive effects of tocotrienol-enriched mixed fraction (TEMF) on atherogenesis remains unclear. Objective: To investigate the preventive effects of TEMF supplementation on early and established atherosclerosis. Methods: Twenty New Zealand white rabbits were divided into TEMF (n=10) and placebo (n=10) groups. Treatments were given by oral gavage for 8 weeks followed by 1% high cholesterol diet (HCD) for another two (to induce early atherosclerosis) or eight weeks (established atherosclerosis). At the end of the study

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Zhu, Yuhua, Xuemei Xian, Zhenzhen Wang, et al. "Research Progress on the Relationship between Atherosclerosis and Inflammation." Biomolecules 8, no. 3 (2018): 80. http://dx.doi.org/10.3390/biom8030080.

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Atherosclerosis is a chronic inflammatory disease; unstable atherosclerotic plaque rupture, vascular stenosis, or occlusion caused by platelet aggregation and thrombosis lead to acute cardiovascular disease. Atherosclerosis-related inflammation is mediated by proinflammatory cytokines, inflammatory signaling pathways, bioactive lipids, and adhesion molecules. This review discusses the effects of inflammation and the systemic inflammatory signaling pathway on atherosclerosis, the role of related signaling pathways in inflammation, the formation of atherosclerosis plaques, and the prospects of t

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Kim, Jong S., Yeon-Jung Kim, Sung-Ho Ahn, and Bum J. Kim. "Location of cerebral atherosclerosis: Why is there a difference between East and West?" International Journal of Stroke 13, no. 1 (2016): 35–46. http://dx.doi.org/10.1177/1747493016647736.

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Intracranial atherosclerosis is more prevalent in Asian patients, whereas extracranial atherosclerosis is more common in individuals from western countries. The reasons for this discrepancy remain unknown. We reviewed the relevant literature and discussed the currently available information. Although the study population, diagnostic modality, and risk factor definitions differ between studies, hypercholesterolemia is more correlated with extracranial atherosclerosis than intracranial atherosclerosis. The difference in hypercholesterolemia prevalence is one of the main reasons for racial differ

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Zhao, Bing, and Lihong Gong. "Exploring the Treatment of Coronary Artery Atherosclerosis from the Direction of Inflammatory Vesicles with Wind-Extinguishing and Phlegm-Resolving Medicine." Journal of Clinical and Nursing Research 6, no. 1 (2022): 105–10. http://dx.doi.org/10.26689/jcnr.v6i1.2934.

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Atherosclerosis is a fundamental pathological change in coronary heart disease, with vulnerable plaque formation leading to decreased plaque stability and plaque rupture, and is a major cause of acute cardiovascular events. The inflammatory response is an important mechanism in the development and progression of atherosclerosis, and plaque stability is closely related to the inflammatory response. In recent years, the role of NLRP3 inflammatory vesicles, which are involved in macrophage foaminess, in the inflammatory response to atherosclerosis has received increasing attention. Chinese medici

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Patel, Divyakshi, Gauri Mahajan, and Neeraj Mahajan. "The link between gut microbiota and atherosclerosis." Indian Journal of Clinical Anatomy and Physiology 10, no. 3 (2023): 145–48. http://dx.doi.org/10.18231/j.ijcap.2023.032.

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Infections have been linked to development of cardiovascular complaint and atherosclerosis. Cardio vascular conditions like atherosclerosis are the major cause of mortality and morbidity in the ultramodern society. The rupture of atherosclerotic plaque can induce thrombus conformation, which is the main cause of acute cardiovascular events. Lately, numerous studies have demonstrated that there are some connections between microbiota and atherosclerosis. There are three metabolite pathways by which gut microbiota can affect atherosclerosis. Either original or distant- causing inflammation which

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Jednacz, Ewa, and Lidia Rutkowska-Sak. "Atherosclerosis in Juvenile Idiopathic Arthritis." Mediators of Inflammation 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/714732.

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Atherosclerosis is a chronic inflammatory disease of the arteries. Clinical consequences of the atherosclerotic process occur in the adult population, however atherosclerotic process begins in childhood. The classic risk factors for atherosclerosis include obesity, dyslipidaemia, age, gender or family history. In recent years, attention has been drawn to the similarity between atherosclerotic inflammatory processes and inflammatory changes in the course of systemic connective tissue disease, in particular systemic lupus etythematosus (SLE) or rheumatoid arthritis (RA). There is also observed t

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Song, Boce, Yulong Bie, Haoxin Feng, Beili Xie, Mingwang Liu, and Fuhai Zhao. "Inflammatory factors driving atherosclerotic plaque progression new insights." Journal of Translational Internal Medicine 10, no. 1 (2022): 36–47. http://dx.doi.org/10.2478/jtim-2022-0012.

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Abstract Coronary atherosclerosis is a chronic inflammatory disease that can lead to varying degrees of blood flow obstruction and a common pathophysiological basis of cardiovascular disease. Inflammatory factors run through the whole process of atherosclerotic lesions. Macrophages, T cells, and neutrophils play important roles in the process of atherosclerotic inflammation. Considering the evolutionary characteristics, atherosclerosis can be divided into different stages as early atherosclerotic plaque, plaque formation stage, and plaque rupture stage. In this paper, the changes in inflammato

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Wei, Chen, Yubing Shi, Hongge Zhang, Huihui Fang, Yangjie Zuo, and Jing Dong. "The role of endothelial cells in the formation and progression of atherosclerosis." International Journal of Multidisciplinary Research and Growth Evaluation 4, no. 5 (2023): 732–37. http://dx.doi.org/10.54660/.ijmrge.2023.4.5.732-737.

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The functions of endothelial cells include physical barriers, sensory organs and endocrine organs, and all three of its functional abnormalities will lead to endothelial cell dysfunction, which will lead to the formation of atherosclerotic lesion initiation and continue to play an important role in the atherosclerotic process. Based on domestic and international research on endothelial cells and atherosclerosis, various causes of endothelial cell dysfunction and their important roles in the process of atherosclerosis will be explored, analyzed and synthesized, and finally the relationship betw

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SHAN, Zhen, Chen YAO, Zi-lun LI, et al. "Differentially expressed microRNAs at different stages of atherosclerosis in ApoE-deficient mice." Chinese Medical Journal 126, no. 3 (2013): 515–20. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20122289.

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Background Atherosclerosis is the primary cause of cardiovascular disease, carotid artery disease, and peripheral vascular disease. However, it is hard to obtain human arterial tissue at different stages of atherosclerosis for a systematic study. The ApoE-deficient (ApoE-/-) mice predictably develop spontaneous atherosclerotic plaques with numerous features similar to the human lesions and contain nearly the entire spectrum of lesions observed during atherogenesis in humans. MicroRNA expression profiles at different stages of atherosclerosis in ApoE-deficient mice were screened to find out the

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Szabo, Helga, Marton Piroska, Anita Hernyes, et al. "The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea." Applied Sciences 12, no. 22 (2022): 11484. http://dx.doi.org/10.3390/app122211484.

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Background: Obstructive sleep apnoea (OSA) and gut dysbiosis are known risk factors for atherosclerosis. However, only very few studies have been focused on the relationship between OSA, atherosclerosis, and the intestinal microbiome, all in animal models. Methods: Twenty-two patients with OSA, 16 with and 6 without carotid atherosclerosis were involved in the study. After a diagnostic sleep examination, the intima media thickness (IMT) was measured and plaques were found using carotid ultrasound. Blood was also drawn for metabolic profile, and a stool sample was provided for 16S ribosomal RNA

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Eitzman, Daniel T., Randal J. Westrick, Zuojun Xu, Julia Tyson, and David Ginsburg. "Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery." Blood 96, no. 13 (2000): 4212–15. http://dx.doi.org/10.1182/blood.v96.13.4212.

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Abstract Dissolution of the fibrin blood clot is regulated in large part by plasminogen activator inhibitor-1 (PAI-1). Elevated levels of plasma PAI-1 may be an important risk factor for atherosclerotic vascular disease and are associated with premature myocardial infarction. The role of the endogenous plasminogen activation system in limiting thrombus formation following atherosclerotic plaque disruption is unknown. This study found that genetic deficiency for PAI-1, the primary physiologic regulator of tissue-type plasminogen activator (tPA), prolonged the time to occlusive thrombosis follow

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Eitzman, Daniel T., Randal J. Westrick, Zuojun Xu, Julia Tyson, and David Ginsburg. "Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery." Blood 96, no. 13 (2000): 4212–15. http://dx.doi.org/10.1182/blood.v96.13.4212.h8004212_4212_4215.

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Dissolution of the fibrin blood clot is regulated in large part by plasminogen activator inhibitor-1 (PAI-1). Elevated levels of plasma PAI-1 may be an important risk factor for atherosclerotic vascular disease and are associated with premature myocardial infarction. The role of the endogenous plasminogen activation system in limiting thrombus formation following atherosclerotic plaque disruption is unknown. This study found that genetic deficiency for PAI-1, the primary physiologic regulator of tissue-type plasminogen activator (tPA), prolonged the time to occlusive thrombosis following photo

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Kishimoto, Yoshimi, Kazuo Kondo, and Yukihiko Momiyama. "The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases." International Journal of Molecular Sciences 22, no. 3 (2021): 1200. http://dx.doi.org/10.3390/ijms22031200.

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Atherosclerotic disease, such as coronary artery disease (CAD), is known to be a chronic inflammatory disease, as well as an age-related disease. Excessive oxidative stress produced by reactive oxygen species (ROS) contributes to the pathogenesis of atherosclerosis. Sestrin2 is an anti-oxidant protein that is induced by various stresses such as hypoxia, DNA damage, and oxidative stress. Sestrin2 is also suggested to be associated with aging. Sestrin2 is expressed and secreted mainly by macrophages, endothelial cells, and cardiomyocytes. Sestrin2 plays an important role in suppressing the produ

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Burger, Fabienne, Daniela Baptista, Aline Roth, Karim J. Brandt, and Kapka Miteva. "The E3 Ubiquitin Ligase Peli1 Deficiency Promotes Atherosclerosis Progression." Cells 11, no. 13 (2022): 2014. http://dx.doi.org/10.3390/cells11132014.

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Background: Atherosclerosis is a chronic inflammatory vascular disease and the main cause of death and morbidity. Emerging evidence suggests that ubiquitination plays an important role in the pathogenesis of atherosclerosis including control of vascular inflammation, vascular smooth muscle cell (VSMC) function and atherosclerotic plaque stability. Peli1 a type of E3 ubiquitin ligase has emerged as a critical regulator of innate and adaptive immunity, however, its role in atherosclerosis remains to be elucidated. Methods: Apoe−/− mice and Peli1-deficient Apoe−/− Peli1−/− mice were subject to hi

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Qiao, Z., J. Ren, and H. Chen. "Simvastatin Reduces Expression and Activity of Lipoprotein-Associated Phospholipase A2 in the Aorta of Hypercholesterolaemic Atherosclerotic Rabbits." Journal of International Medical Research 37, no. 4 (2009): 1029–37. http://dx.doi.org/10.1177/147323000903700407.

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Lipoprotein-associated phospholipase A2 (Lp-PLA2) contributes to atherosclerotic plaque instability and subsequent sudden coronary death. Statins are associated with decreased stroke risk and may improve stability of atherosclerotic plaques. The present study investigated the effect of simvastatin on expression of Lp-PLA2 levels in atherosclerotic plaques and on Lp-PLA2 activity in atherosclerotic aortas. Rabbits were a fed chow (control group) or a high-cholesterol diet (atherosclerosis group) for 12 weeks. An additional group on the high-cholesterol diet received simvastatin (5 mg/kg per day

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Saranchina, J. V., S. V. Dutova, O. Y. Kilina, N. V. Khanarin, and T. S. Kulakova. "Features of interleukin-19 production in patients with atherosclerosis." Siberian Journal of Clinical and Experimental Medicine 36, no. 2 (2021): 52–60. http://dx.doi.org/10.29001/2073-8552-2021-36-2-52-60.

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Objective. To study the features of local and systemic production of interleukin-19 in patients with atherosclerosis.Material and Methods. The study comprised a total of 46 patients (26 women and 20 men) treated for arterial hypertension in the therapeutic department of Republican Clinical Hospital named after G.Y. Remishevskaya. The mean age of subjects was 63.4 ± 3.2 years. The control group included 40 patients (23 women and 17 men aged 44.7 ± 5.5 years) who did not have atherosclerosis. Samples of atherosclerotic plaques and venous blood were examined. Atherosclerotic plaques were obtained

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Tu, Shuangshuang, Wenming He, Jinru Han, Aiguo Wu, and Wenzhi Ren. "Advances in imaging and treatment of atherosclerosis based on organic nanoparticles." APL Bioengineering 6, no. 4 (2022): 041501. http://dx.doi.org/10.1063/5.0127835.

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Atherosclerosis, a systemic chronic inflammatory disease, can lead to thrombosis and vascular occlusion, thereby inducing a series of serious vascular diseases. Currently, distinguishing unstable plaques early and achieving more effective treatment are the two main clinical concerns in atherosclerosis. Organic nanoparticles have great potential in atherosclerotic imaging and treatment, showing superior biocompatibility, drug-loading capacity, and synthesis. This article illustrates the process of atherosclerosis onset and the key targeted cells, then systematically summarizes recent progress m

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Henriques, Joana, Ana M. Amaro, and Ana P. Piedade. "Understanding Atherosclerosis Pathophysiology: Can Additive Manufacturing Be Helpful?" Polymers 15, no. 3 (2023): 480. http://dx.doi.org/10.3390/polym15030480.

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Atherosclerosis is one of the leading causes of death worldwide. Although this subject arouses much interest, there are limitations associated with the biomechanical investigation done in atherosclerotic tissues, namely the unstandardized tests for the mechanical characterization of these tissues and the inherent non-consensual results obtained. The variability of tests and typologies of samples hampers direct comparisons between results and hinders the complete understanding of the pathologic process involved in atherosclerosis development and progression. Therefore, a consensual and definiti

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Millon, Antoine, Emmanuelle Canet-Soulas, Loic Boussel, Zahi Fayad, and Philippe Douek. "Animal models of atherosclerosis and magnetic resonance imaging for monitoring plaque progression." Vascular 22, no. 3 (2014): 221–37. http://dx.doi.org/10.1177/1708538113478758.

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Atherosclerosis, the main cause of heart attack and stroke, is the leading cause of death in most modern countries. Preventing clinical events depends on a better understanding of the mechanism of atherosclerotic plaque destabilization. Our knowledge on the characteristics of vulnerable plaques in humans has grown past decades. Histological studies have provided a precise definition of high-risk lesions and novel imaging methods for human atherosclerotic plaque characterization have made significant progress. However the pathological mechanisms leading from stable lesions to the formation of v

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Zhang, Lili, Lihua Li, Yalan Li, et al. "Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis." Diabetes and Vascular Disease Research 20, no. 1 (2023): 147916412311590. http://dx.doi.org/10.1177/14791641231159009.

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Aims Diabetes will lead to serious complications, of which atherosclerosis is the most dangerous. This study aimed to explore the mechanisms of diabetic atherosclerosis. Methods ApoE−/− mice were fed with an high-fat diet diet and injected with streptozotocin to establish an in vivo diabetic atherosclerotic model. RAW 264.7 cells were treated with oxidized low-density lipoprotein particles (ox-LDL) and high glucose to produce an in vitro diabetic atherosclerotic model. Results In this study, we showed that diabetes promoted the progression of atherosclerosis in ApoE−/− mice and that high gluco

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Sebatana, Reabetswe, Kahwenga D. Kudzai, Allan Magura, et al. "An Insight to Nanoliposomes as Smart Radiopharmaceutical Delivery Tools for Imaging Atherosclerotic Plaques: Positron Emission Tomography Applications." Pharmaceutics 17, no. 2 (2025): 240. https://doi.org/10.3390/pharmaceutics17020240.

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Atherosclerosis is a chronic progressive disease which is known to cause acute cardiovascular events as well as cerebrovascular events with high mortality. Unlike many other diseases, atherosclerosis is often diagnosed only after an acute or fatal event. At present, the clinical problems of atherosclerosis mainly involve the difficulty in confirming the plaques or identifying the stability of the plaques in the early phase. In recent years, the development of nanotechnology has come with various advantages including non-invasive imaging enhancement, which can be studied for the imaging of athe

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Tsui, Pi-Fen, Chin-Sheng Lin, Ling-Jun Ho, and Jenn-Haung Lai. "Spices and Atherosclerosis." Nutrients 10, no. 11 (2018): 1724. http://dx.doi.org/10.3390/nu10111724.

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Cardiovascular disease is one of the leading causes of death and disability in the world. Atherosclerosis, characterized by lipid accumulation and chronic inflammation in the vessel wall, is the main feature of cardiovascular disease. Although the amounts of fruits and vegetables present in the diets vary by country, diets, worldwide, contain large amounts of spices; this may have positive or negative effects on the initiation and development of atherosclerosis. In this review, we focused on the potential protective effects of specific nutrients from spices, such as pepper, ginger, garlic, oni

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Mohmand-Borkowski, Adam, and Tomasz Rozmyslowicz. "Immunohistochemical Localization of Fibroblast Activation Protein in Coronary Arteries with Different Forms of Atherosclerosis." Metabolites 14, no. 11 (2024): 573. http://dx.doi.org/10.3390/metabo14110573.

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Background: Fibroblast activation protein (FAP) is a cell surface glycoprotein expressed by myofibroblasts in areas of active tissue remodeling. It plays a potentially important role in cardiac remodeling, atherosclerotic plaque formation, and plaque rupture. Given the distinct pathophysiology and morphology of different forms of atherosclerosis, we analyzed FAP expression in human coronary vessels with no coronary artery disease, atherosclerotic plaques at different levels of progression, and other distinct forms of coronary disease in post bypass vein grafting and cardiac allograft vasculopa

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Gencer, Selin, Bryce R. Evans, Emiel P. C. van der Vorst, Yvonne Döring, and Christian Weber. "Inflammatory Chemokines in Atherosclerosis." Cells 10, no. 2 (2021): 226. http://dx.doi.org/10.3390/cells10020226.

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Atherosclerosis is a long-term, chronic inflammatory disease of the vessel wall leading to the formation of occlusive or rupture-prone lesions in large arteries. Complications of atherosclerosis can become severe and lead to cardiovascular diseases (CVD) with lethal consequences. During the last three decades, chemokines and their receptors earned great attention in the research of atherosclerosis as they play a key role in development and progression of atherosclerotic lesions. They orchestrate activation, recruitment, and infiltration of immune cells and subsequent phenotypic changes, e.g.,

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Lu, Shynie. "Interferon regulatory factor 3 is a potential biomarker to predict the process of atherosclerosis." BIO Web of Conferences 61 (2023): 01025. http://dx.doi.org/10.1051/bioconf/20236101025.

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Cardiovascular diseases is one of the major public health and medical concerns globally. Atherosclerosis is a condition where plaque build-up narrows the blood vessels, ultimately preventing sufficient blood flow to the heart. In current research, the role played by the human innate immune system in the development of atherosclerosis is a topic of interest. Although the specific relations require further studies, macrophages have been identified to play a key role in the progression of atherosclerosis due to their ability to mediate inflammation. Nevertheless, the mechanism that how macrophage

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